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David J. Friedman, M.D.

TitleAssistant Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Rn 227b
99 Brookline Ave
Boston MA 02215
Phone617/667-0253
Fax617/667-2913

 Biography 
 awards and honors
2002 - Harvard Medical School Class of 2002 Housestaff Teaching Award
2003 - Harvard Medical School Class of 2003 Housestaff Teaching Award
2008 - Excellence in Tutoring Award
2010 - Type 1 Diabetes Ideation Award
2011 - Clinical Scientist Development Award

 Mentoring 
 current student opportunities
Available: 10/15/12, Expires: 06/30/14

African Americans develop kidney failure at rates 4-5 times higher than Caucasian Americans. We found genetic variants in a gene called APOL1 that account for most of this risk difference. These genetic disease-causing variants are amongst the most powerful every discovered, but we know almost nothing about the underlying mechanisms. We are working to understand the role of the ApoL1 protein in the kidney and why the risk variants cause kidney disease. Potential projects range from human genetics/genomics to mechanistic studies in cell and molecular biology.

This opportunity would be funded by a fellowship from the Doris Duke Charitable Foundation, a major sponsor of the project. Please contact David Friedman, M.D., for more information.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Raper J, Friedman DJ. Parasitology: Molecular one-upmanship. Nature. 2013 Sep 19; 501(7467):322-3.
    View in: PubMed
  2. Berg AH, Drechsler C, Wenger J, Buccafusca R, Hod T, Kalim S, Ramma W, Parikh SM, Steen H, Friedman DJ, Danziger J, Wanner C, Thadhani R, Karumanchi SA. Carbamylation of serum albumin as a risk factor for mortality in patients with kidney failure. Sci Transl Med. 2013 Mar 6; 5(175):175ra29.
    View in: PubMed
  3. Genovese G, Friedman DJ, Pollak MR. APOL1 variants and kidney disease in people of recent African ancestry. Nat Rev Nephrol. 2013 Feb 12; 9(4):240-4.
    View in: PubMed
  4. Zaitlen N, Lindström S, Pasaniuc B, Cornelis M, Genovese G, Pollack S, Barton A, Bickeböller H, Bowden DW, Eyre S, Freedman BI, Friedman DJ, Field JK, Groop L, Haugen A, Heinrich J, Henderson BE, Hicks PJ, Hocking LJ, Kolonel LN, Landi MT, Langefeld CD, Le Marchand L, Meister M, Morgan AW, Raji OY, Risch A, Rosenberger A, Scherf D, Steer S, Walshaw M, Waters KM, Wilson AG, Wordsworth P, Zienolddiny S, Tchetgen ET, Haiman C, Hunter DJ, Plenge RM, Worthington J, Christiani DC, Schaumberg DA, Chasman DI, Altshuler D, Voight B, Kraft P, Patterson N, Price AL. Informed conditioning on clinical covariates increases power in case-control association studies. PLoS Genet. 2012 Nov; 8(11):e1003032.
    View in: PubMed
  5. Pasquale LR, Loomis SJ, Kang JH, Yaspan BL, Abdrabou W, Budenz DL, Chen TC, Delbono E, Friedman DS, Gaasterland D, Gaasterland T, Grosskreutz CL, Lee RK, Lichter PR, Liu Y, McCarty CA, Moroi SE, Olson LM, Realini T, Rhee DJ, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Allingham RR, Pericak-Vance MA, Weinreb RN, Zhang K, Hauser MA, Richards JE, Haines JL, Wiggs JL. CDKN2B-AS1 Genotype-Glaucoma Feature Correlations in Primary Open-Angle Glaucoma Patients From the United States. Am J Ophthalmol. 2013 Feb; 155(2):342-353.e5.
    View in: PubMed
  6. Baskaran M, Perera SA, Nongpiur ME, Tun TA, Park J, Kumar RS, Friedman DS, Aung T. Angle assessment by EyeCam, goniophotography, and gonioscopy. J Glaucoma. 2012 Sep; 21(7):493-7.
    View in: PubMed
  7. Baskaran M, Aung T, Friedman DS, Tun TA, Perera SA. Comparison of EyeCam and anterior segment optical coherence tomography in detecting angle closure. Acta Ophthalmol. 2012 Dec; 90(8):e621-5.
    View in: PubMed
  8. Friedman DJ, Bhatt N, Hayman NS, Nichols BJ, Herman M, Nikolaev N, Danziger J. Impact of activated vitamin D on insulin resistance in nondiabetic chronic kidney disease patients. Clin Endocrinol (Oxf). 2012 Jul; 77(1):56-61.
    View in: PubMed
  9. Wiggs JL, Yaspan BL, Hauser MA, Kang JH, Allingham RR, Olson LM, Abdrabou W, Fan BJ, Wang DY, Brodeur W, Budenz DL, Caprioli J, Crenshaw A, Crooks K, Delbono E, Doheny KF, Friedman DS, Gaasterland D, Gaasterland T, Laurie C, Lee RK, Lichter PR, Loomis S, Liu Y, Medeiros FA, McCarty C, Mirel D, Moroi SE, Musch DC, Realini A, Rozsa FW, Schuman JS, Scott K, Singh K, Stein JD, Trager EH, Vanveldhuisen P, Vollrath D, Wollstein G, Yoneyama S, Zhang K, Weinreb RN, Ernst J, Kellis M, Masuda T, Zack D, Richards JE, Pericak-Vance M, Pasquale LR, Haines JL. Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma. PLoS Genet. 2012; 8(4):e1002654.
    View in: PubMed
  10. Huggins KN, Mathews TA, Locke JL, Szeliga KT, Friedman DP, Bennett AJ, Jones SR. Effects of early life stress on drinking and serotonin system activity in rhesus macaques: 5-hydroxyindoleacetic acid in cerebrospinal fluid predicts brain tissue levels. Alcohol. 2012 Jun; 46(4):371-6.
    View in: PubMed
  11. Sng CC, Foo LL, Cheng CY, Allen JC, He M, Krishnaswamy G, Nongpiur ME, Friedman DS, Wong TY, Aung T. Determinants of anterior chamber depth: the Singapore Chinese Eye Study. Ophthalmology. 2012 Jun; 119(6):1143-50.
    View in: PubMed
  12. Pollak MR, Genovese G, Friedman DJ. APOL1 and kidney disease. Curr Opin Nephrol Hypertens. 2012 Mar; 21(2):179-82.
    View in: PubMed
  13. Foo LL, Nongpiur ME, Allen JC, Perera SA, Friedman DS, He M, Cheng CY, Wong TY, Aung T. Determinants of angle width in Chinese Singaporeans. Ophthalmology. 2012 Feb; 119(2):278-82.
    View in: PubMed
  14. Corcoran CA, Pierre PJ, Haddad T, Bice C, Suomi SJ, Grant KA, Friedman DP, Bennett AJ. Long-term effects of differential early rearing in rhesus macaques: behavioral reactivity in adulthood. Dev Psychobiol. 2012 Jul; 54(5):546-55.
    View in: PubMed
  15. Kopp JB, Nelson GW, Sampath K, Johnson RC, Genovese G, An P, Friedman D, Briggs W, Dart R, Korbet S, Mokrzycki MH, Kimmel PL, Limou S, Ahuja TS, Berns JS, Fryc J, Simon EE, Smith MC, Trachtman H, Michel DM, Schelling JR, Vlahov D, Pollak M, Winkler CA. APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol. 2011 Nov; 22(11):2129-37.
    View in: PubMed
  16. Kanji Z, Powe CE, Wenger JB, Huang C, Ankers E, Sullivan DA, Collerone G, Powe NR, Tonelli M, Bhan I, Bernhardy AJ, Dibartolo S, Friedman D, Genovese G, Pollak MR, Thadhani R. Genetic variation in APOL1 associates with younger age at hemodialysis initiation. J Am Soc Nephrol. 2011 Nov; 22(11):2091-7.
    View in: PubMed
  17. Friedman DJ, Kozlitina J, Genovese G, Jog P, Pollak MR. Population-based risk assessment of APOL1 on renal disease. J Am Soc Nephrol. 2011 Nov; 22(11):2098-105.
    View in: PubMed
  18. Friedman DJ, Turka LA, Robson SC. There's a goat behind door number 3: from Monty Hall to medicine. J Clin Invest. 2011 Oct; 121(10):3819-21.
    View in: PubMed
  19. Friedman DJ, Pollak MR. Genetics of kidney failure and the evolving story of APOL1. J Clin Invest. 2011 Sep; 121(9):3367-74.
    View in: PubMed
  20. Borchert MS, Varma R, Cotter SA, Tarczy-Hornoch K, McKean-Cowdin R, Lin JH, Wen G, Azen SP, Torres M, Tielsch JM, Friedman DS, Repka MX, Katz J, Ibironke J, Giordano L. Risk factors for hyperopia and myopia in preschool children the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies. Ophthalmology. 2011 Oct; 118(10):1966-73.
    View in: PubMed
  21. McKean-Cowdin R, Varma R, Cotter SA, Tarczy-Hornoch K, Borchert MS, Lin JH, Wen G, Azen SP, Torres M, Tielsch JM, Friedman DS, Repka MX, Katz J, Ibironke J, Giordano L. Risk factors for astigmatism in preschool children: the multi-ethnic pediatric eye disease and Baltimore pediatric eye disease studies. Ophthalmology. 2011 Oct; 118(10):1974-81.
    View in: PubMed
  22. Wang FH, Liang YB, Peng XY, Wang JJ, Zhang F, Wei WB, Sun LP, Friedman DS, Wang NL, Wong TY. Risk factors for diabetic retinopathy in a rural Chinese population with type 2 diabetes: the Handan Eye Study. Acta Ophthalmol. 2011 Jun; 89(4):e336-43.
    View in: PubMed
  23. Wang Y, Liang YB, Sun LP, Duan XR, Yuan RZ, Wong TY, Yi P, Friedman DS, Wang NL, Wang JJ. Prevalence and causes of amblyopia in a rural adult population of Chinese the Handan Eye Study. Ophthalmology. 2011 Feb; 118(2):279-83.
    View in: PubMed
  24. Freedman BI, Kopp JB, Langefeld CD, Genovese G, Friedman DJ, Nelson GW, Winkler CA, Bowden DW, Pollak MR. The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans. J Am Soc Nephrol. 2010 Sep; 21(9):1422-6.
    View in: PubMed
  25. Genovese G, Friedman DJ, Ross MD, Lecordier L, Uzureau P, Freedman BI, Bowden DW, Langefeld CD, Oleksyk TK, Uscinski Knob AL, Bernhardy AJ, Hicks PJ, Nelson GW, Vanhollebeke B, Winkler CA, Kopp JB, Pays E, Pollak MR. Association of trypanolytic ApoL1 variants with kidney disease in African Americans. Science. 2010 Aug 13; 329(5993):841-5.
    View in: PubMed
  26. Cates JM, Friedman DB, Seeley EH, Dupont WD, Schwartz HS, Holt GE, Caprioli RM, Young PP. Proteomic analysis of osteogenic sarcoma: association of tumour necrosis factor with poor prognosis. Int J Exp Pathol. 2010 Aug; 91(4):335-49.
    View in: PubMed
  27. Zheng Y, Wong TY, Mitchell P, Friedman DS, He M, Aung T. Distribution of ocular perfusion pressure and its relationship with open-angle glaucoma: the singapore malay eye study. Invest Ophthalmol Vis Sci. 2010 Jul; 51(7):3399-404.
    View in: PubMed
  28. Peng XY, Wang FH, Liang YB, Wang JJ, Sun LP, Peng Y, Friedman DS, Liew G, Wang NL, Wong TY. Retinopathy in persons without diabetes: the Handan Eye Study. Ophthalmology. 2010 Mar; 117(3):531-7, 537.e1-2.
    View in: PubMed
  29. Friedman D, de Chastelaine M, Nessler D, Malcolm B. Changes in familiarity and recollection across the lifespan: an ERP perspective. Brain Res. 2010 Jan 15; 1310:124-41.
    View in: PubMed
  30. Friedman DJ, Afkarian M, Tamez H, Bhan I, Isakova T, Wolf M, Ankers E, Ye J, Tonelli M, Zoccali C, Kuro-o M, Moe O, Karumanchi SA, Thadhani R. Klotho variants and chronic hemodialysis mortality. J Bone Miner Res. 2009 Nov; 24(11):1847-55.
    View in: PubMed
  31. Friedman DJ, Künzli BM, A-Rahim YI, Sevigny J, Berberat PO, Enjyoji K, Csizmadia E, Friess H, Robson SC. From the Cover: CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease. Proc Natl Acad Sci U S A. 2009 Sep 29; 106(39):16788-93.
    View in: PubMed
  32. Friedman DS, Repka MX, Katz J, Giordano L, Ibironke J, Hawse P, Tielsch JM. Prevalence of amblyopia and strabismus in white and African American children aged 6 through 71 months the Baltimore Pediatric Eye Disease Study. Ophthalmology. 2009 Nov; 116(11):2128-34.e1-2.
    View in: PubMed
  33. Liang YB, Wong TY, Sun LP, Tao QS, Wang JJ, Yang XH, Xiong Y, Wang NL, Friedman DS. Refractive errors in a rural Chinese adult population the Handan eye study. Ophthalmology. 2009 Nov; 116(11):2119-27.
    View in: PubMed
  34. Liang YB, Friedman DS, Wong TY, Wang FH, Duan XR, Yang XH, Zhou Q, Tao Q, Zhan SY, Sun LP, Wang NL. Rationale, design, methodology, and baseline data of a population-based study in rural China: the Handan Eye Study. Ophthalmic Epidemiol. 2009 Mar-Apr; 16(2):115-27.
    View in: PubMed
  35. Giordano L, Friedman DS, Repka MX, Katz J, Ibironke J, Hawes P, Tielsch JM. Prevalence of refractive error among preschool children in an urban population: the Baltimore Pediatric Eye Disease Study. Ophthalmology. 2009 Apr; 116(4):739-46, 746.e1-4.
    View in: PubMed
  36. Wang FH, Liang YB, Zhang F, Wang JJ, Wei WB, Tao QS, Sun LP, Friedman DS, Wang NL, Wong TY. Prevalence of diabetic retinopathy in rural China: the Handan Eye Study. Ophthalmology. 2009 Mar; 116(3):461-7.
    View in: PubMed
  37. Friedman DJ, Talbert ME, Bowden DW, Freedman BI, Mukanya Y, Enjyoji K, Robson SC. Functional ENTPD1 polymorphisms in African Americans with diabetes and end-stage renal disease. Diabetes. 2009 Apr; 58(4):999-1006.
    View in: PubMed
  38. Duan XR, Liang YB, Friedman DS, Sun LP, Wei WB, Wang JJ, Wang GL, Liu W, Tao QS, Wang NL, Wong TY. Prevalence and associations of epiretinal membranes in a rural Chinese adult population: the Handan Eye Study. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2018-23.
    View in: PubMed
  39. Enjyoji K, Kotani K, Thukral C, Blumel B, Sun X, Wu Y, Imai M, Friedman D, Csizmadia E, Bleibel W, Kahn BB, Robson SC. Deletion of cd39/entpd1 results in hepatic insulin resistance. Diabetes. 2008 Sep; 57(9):2311-20.
    View in: PubMed
  40. Oppermann M, Friedman DJ, Faulhaber-Walter R, Mizel D, Castrop H, Enjyoji K, Robson SC, Schnermann J. Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F965-70.
    View in: PubMed
  41. Broman AT, Quigley HA, West SK, Katz J, Munoz B, Bandeen-Roche K, Tielsch JM, Friedman DS, Crowston J, Taylor HR, Varma R, Leske MC, Bengtsson B, Heijl A, He M, Foster PJ. Estimating the rate of progressive visual field damage in those with open-angle glaucoma, from cross-sectional data. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):66-76.
    View in: PubMed
  42. Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007 Jun 11; 204(6):1257-65.
    View in: PubMed
  43. Friedman DJ, Rennke HG, Csizmadia E, Enjyoji K, Robson SC. The vascular ectonucleotidase ENTPD1 is a novel renoprotective factor in diabetic nephropathy. Diabetes. 2007 Sep; 56(9):2371-9.
    View in: PubMed
  44. Dwyer KM, Deaglio S, Gao W, Friedman D, Strom TB, Robson SC. CD39 and control of cellular immune responses. Purinergic Signal. 2007 Mar; 3(1-2):171-80.
    View in: PubMed
  45. Chernova MN, Jiang L, Friedman DJ, Darman RB, Lohi H, Kere J, Vandorpe DH, Alper SL. Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. J Biol Chem. 2005 Mar 4; 280(9):8564-80.
    View in: PubMed
  46. Aung T, Friedman DS, Chew PT, Ang LP, Gazzard G, Lai YF, Yip L, Lai H, Quigley H, Seah SK. Long-term outcomes in asians after acute primary angle closure. Ophthalmology. 2004 Aug; 111(8):1464-9.
    View in: PubMed
  47. Friedman DS, Wolfs RC, O'Colmain BJ, Klein BE, Taylor HR, West S, Leske MC, Mitchell P, Congdon N, Kempen J. Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol. 2004 Apr; 122(4):532-8.
    View in: PubMed
  48. Congdon N, O'Colmain B, Klaver CC, Klein R, Muñoz B, Friedman DS, Kempen J, Taylor HR, Mitchell P. Causes and prevalence of visual impairment among adults in the United States. Arch Ophthalmol. 2004 Apr; 122(4):477-85.
    View in: PubMed
  49. Friedman DS, O'Colmain BJ, Muñoz B, Tomany SC, McCarty C, de Jong PT, Nemesure B, Mitchell P, Kempen J. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004 Apr; 122(4):564-72.
    View in: PubMed
  50. Congdon N, Vingerling JR, Klein BE, West S, Friedman DS, Kempen J, O'Colmain B, Wu SY, Taylor HR. Prevalence of cataract and pseudophakia/aphakia among adults in the United States. Arch Ophthalmol. 2004 Apr; 122(4):487-94.
    View in: PubMed
  51. Chernova MN, Stewart AK, Jiang L, Friedman DJ, Kunes YZ, Alper SL. Structure-function relationships of AE2 regulation by Ca(i)(2+)-sensitive stimulators NH(4+) and hypertonicity. Am J Physiol Cell Physiol. 2003 May; 284(5):C1235-46.
    View in: PubMed
  52. Li CJ, Wang C, Friedman DJ, Pardee AB. Reciprocal modulations between p53 and Tat of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A. 1995 Jun 6; 92(12):5461-4.
    View in: PubMed
  53. Li CJ, Friedman DJ, Wang C, Metelev V, Pardee AB. Induction of apoptosis in uninfected lymphocytes by HIV-1 Tat protein. Science. 1995 Apr 21; 268(5209):429-31.
    View in: PubMed
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