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Joseph H Schwab, M.D.

TitleInstructor in Orthopedic Surgery
InstitutionMassachusetts General Hospital
DepartmentOrthopedic Surgery
AddressMassachusetts General Hospital
Ortho - Yawkey 2100
55 Fruit St
Boston MA 02114
Phone617/726-8636

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Schwab JH, Springfield DS, Raskin KA, Mankin HJ, Hornicek FJ. What's New in Primary Malignant Musculoskeletal Tumors. J Bone Joint Surg Am. 2013 Dec 18; 95(24):2240-6.
    View in: PubMed
  2. Zhang L, Guo S, Schwab JH, Nielsen GP, Choy E, Ye S, Zhang Z, Mankin H, Hornicek FJ, Duan Z. Tissue microarray immunohistochemical detection of brachyury is not a prognostic indicator in chordoma. PLoS One. 2013; 8(9):e75851.
    View in: PubMed
  3. Boyaci B, Hornicek FJ, Nielsen GP, Delaney TF, Pedlow FX, Mansfield FL, Carrier CS, Harms J, Schwab JH. Epithelioid hemangioma of the spine: a case series of six patients and review of the literature. Spine J. 2013 Dec 1; 13(12):e7-e13.
    View in: PubMed
  4. Ungi T, Moult E, Schwab JH, Fichtinger G. Tracked ultrasound snapshots in percutaneous pedicle screw placement navigation: a feasibility study. Clin Orthop Relat Res. 2013 Dec; 471(12):4047-55.
    View in: PubMed
  5. Chen YL, Liebsch N, Kobayashi W, Goldberg S, Kirsch D, Calkins G, Childs S, Schwab J, Hornicek F, Delaney T. Definitive high-dose photon/proton radiotherapy for unresected mobile spine and sacral chordomas. Spine (Phila Pa 1976). 2013 Jul 1; 38(15):E930-6.
    View in: PubMed
  6. Lyon R, Liu XC, Kubin M, Schwab J. Does extracorporeal shock wave therapy enhance healing of osteochondritis dissecans of the rabbit knee?: a pilot study. Clin Orthop Relat Res. 2013 Apr; 471(4):1159-65.
    View in: PubMed
  7. Raskin KA, Schwab JH, Mankin HJ, Springfield DS, Hornicek FJ. Giant cell tumor of bone. J Am Acad Orthop Surg. 2013 Feb; 21(2):118-26.
    View in: PubMed
  8. Kang J, Botros M, Goldberg S, Giraud C, Nielsen GP, Chen YL, Raskin K, Schwab J, Yoon SS, Hornicek FJ, Delaney TF. The use of radiation therapy in the management of selected patients with atypical lipomas. Sarcoma. 2013; 2013:485483.
    View in: PubMed
  9. Schwab JH, Springfield DS, Raskin KA, Mankin HJ, Hornicek FJ. What's New in Primary Bone Tumors. J Bone Joint Surg Am. 2012 Oct 17; 94(20):1913-9.
    View in: PubMed
  10. Liu X, Nielsen GP, Rosenberg AE, Waterman PR, Yang W, Choy E, Sassi S, Yang S, Harmon DC, Yang C, Schwab JH, Kobayashi E, Mankin HJ, Xavier R, Weissleder R, Duan Z, Hornicek FJ. Establishment and characterization of a novel chordoma cell line: CH22. J Orthop Res. 2012 Oct; 30(10):1666-73.
    View in: PubMed
  11. Boyaci B, Hornicek F, Rosenthal D, Mankin H, Pedlow FX, Carrier C, Harms J, Rosenberg A, Schwab J. Sarcoidosis of the spine: a report of five cases and a review of the literature. J Bone Joint Surg Am. 2012 Apr 4; 94(7):e421-5.
    View in: PubMed
  12. Schwab J, Gasbarrini A, Bandiera S, Boriani L, Amendola L, Picci P, Ferrari S, Boriani S. Osteosarcoma of the mobile spine. Spine (Phila Pa 1976). 2012 Mar 15; 37(6):E381-6.
    View in: PubMed
  13. Peacock ZS, Resnick CM, Susarla SM, Faquin WC, Rosenberg AE, Nielsen GP, Schwab JH, Hornicek F, Ebb DH, Dodson TB, Kaban LB. Do histologic criteria predict biologic behavior of giant cell lesions? J Oral Maxillofac Surg. 2012 Nov; 70(11):2573-80.
    View in: PubMed
  14. Schoenfeld AJ, Hornicek FJ, Pedlow FX, Kobayashi W, Raskin KA, Springfield D, DeLaney TF, Nielsen GP, Mankin HJ, Schwab JH. Chondrosarcoma of the mobile spine: a review of 21 cases treated at a single center. Spine (Phila Pa 1976). 2012 Jan 15; 37(2):119-26.
    View in: PubMed
  15. Boriani S, Bandiera S, Casadei R, Boriani L, Donthineni R, Gasbarrini A, Pignotti E, Biagini R, Schwab JH. Giant cell tumor of the mobile spine: a review of 49 cases. Spine (Phila Pa 1976). 2012 Jan 1; 37(1):E37-45.
    View in: PubMed
  16. Rose PS, Schwab JH, Buchowski JM, Patt JC. Evaluation of the patient presenting with a malignant spinal tumor. Instr Course Lect. 2012; 61:553-65.
    View in: PubMed
  17. Morris CD, Parsons TW, Schwab JH, Panicek DM. Imaging interpretation of oncologic musculoskeletal conditions. Instr Course Lect. 2012; 61:541-51.
    View in: PubMed
  18. Schwab JH, Gasbarrini A, Cappuccio M, Boriani L, De Iure F, Colangeli S, Boriani S. Minimally Invasive Posterior Stabilization Improved Ambulation and Pain Scores in Patients with Plasmacytomas and/or Metastases of the Spine. Int J Surg Oncol. 2011; 2011:239230.
    View in: PubMed
  19. Beck SE, Schwab JH, Rosenthal DI, Rosenberg AE, Grottkau BE. Metachronous osteoid osteoma of the tibia and the T7 vertebral body: a case report. J Bone Joint Surg Am. 2011 Jul 6; 93(13):e73.
    View in: PubMed
  20. Beck SE, Nielsen GP, Raskin KA, Schwab JH. Intraosseous synovial sarcoma of the proximal tibia. Int J Surg Oncol. 2011; 2011:184891.
    View in: PubMed
  21. Le LP, Nielsen GP, Rosenberg AE, Thomas D, Batten JM, Deshpande V, Schwab J, Duan Z, Xavier RJ, Hornicek FJ, Iafrate AJ. Recurrent chromosomal copy number alterations in sporadic chordomas. PLoS One. 2011; 6(5):e18846.
    View in: PubMed
  22. Yang C, Choy E, Hornicek FJ, Wood KB, Schwab JH, Liu X, Mankin H, Duan Z. Histone deacetylase inhibitor PCI-24781 enhances chemotherapy-induced apoptosis in multidrug-resistant sarcoma cell lines. Anticancer Res. 2011 Apr; 31(4):1115-23.
    View in: PubMed
  23. Susa M, Choy E, Liu X, Schwab J, Hornicek FJ, Mankin H, Duan Z. Cyclin G-associated kinase is necessary for osteosarcoma cell proliferation and receptor trafficking. Mol Cancer Ther. 2010 Dec; 9(12):3342-50.
    View in: PubMed
  24. Devisetty K, Kobayashi W, Suit HD, Goldberg SI, Niemierko A, Chen YL, Raskin KA, Schwab JH, Springfield DS, Yoon SS, Hornicek FJ, DeLaney TF. Low-dose neoadjuvant external beam radiation therapy for soft tissue sarcoma. Int J Radiat Oncol Biol Phys. 2011 Jul 1; 80(3):779-86.
    View in: PubMed
  25. Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Mankin H, Duan Z. Blockage of Stat3 with CDDO-Me inhibits tumor cell growth in chordoma. Spine (Phila Pa 1976). 2010 Aug 15; 35(18):1668-75.
    View in: PubMed
  26. Schoenfeld AJ, Hornicek FJ, Pedlow FX, Kobayashi W, Garcia RT, DeLaney TF, Springfield D, Mankin HJ, Schwab JH. Osteosarcoma of the spine: experience in 26 patients treated at the Massachusetts General Hospital. Spine J. 2010 Aug; 10(8):708-14.
    View in: PubMed
  27. Wang X, Wang Y, Yu L, Sakakura K, Visus C, Schwab JH, Ferrone CR, Favoino E, Koya Y, Campoli MR, McCarthy JB, DeLeo AB, Ferrone S. CSPG4 in cancer: multiple roles. Curr Mol Med. 2010 Jun; 10(4):419-29.
    View in: PubMed
  28. Yang C, Hornicek FJ, Wood KB, Schwab JH, Choy E, Iafrate J, Rosenberg A, Nielsen GP, Xavier RJ, Mankin H, Duan Z. Characterization and analysis of human chordoma cell lines. Spine (Phila Pa 1976). 2010 Jun 1; 35(13):1257-64.
    View in: PubMed
  29. Yang C, Choy E, Hornicek FJ, Wood KB, Schwab JH, Liu X, Mankin H, Duan Z. Histone deacetylase inhibitor (HDACI) PCI-24781 potentiates cytotoxic effects of doxorubicin in bone sarcoma cells. Cancer Chemother Pharmacol. 2011 Feb; 67(2):439-46.
    View in: PubMed
  30. Schoenfeld AJ, Koplin SA, Garcia R, Hornicek FJ, Mankin HJ, Raskin KA, Springfield D, Rosenberg AE, Schwab JH. Monostotic fibrous dysplasia of the spine: a report of seven cases. J Bone Joint Surg Am. 2010 Apr; 92(4):984-8.
    View in: PubMed
  31. Susa M, Choy E, Yang C, Schwab J, Mankin H, Hornicek F, Duan Z. Multidrug resistance reversal agent, NSC77037, identified with a cell-based screening assay. J Biomol Screen. 2010 Mar; 15(3):287-96.
    View in: PubMed
  32. Resnick CM, Margolis J, Susarla SM, Schwab JH, Hornicek FJ, Dodson TB, Kaban LB. Maxillofacial and axial/appendicular giant cell lesions: unique tumors or variants of the same disease?--A comparison of phenotypic, clinical, and radiographic characteristics. J Oral Maxillofac Surg. 2010 Jan; 68(1):130-7.
    View in: PubMed
  33. Kim B, Chen YL, Kirsch DG, Goldberg SI, Kobayashi W, Kung JH, Wolfgang JA, Doppke K, Rosenberg AE, Nielsen GP, Raskin KA, Springfield DS, Schwab JH, Gebhardt MC, Yoon SS, Hornicek FJ, DeLaney TF. An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control. Int J Radiat Oncol Biol Phys. 2010 Jul 1; 77(3):843-50.
    View in: PubMed
  34. Schwab JH, Healey JH, Rose P, Casas-Ganem J, Boland PJ. The surgical management of sacral chordomas. Spine (Phila Pa 1976). 2009 Nov 15; 34(24):2700-4.
    View in: PubMed
  35. Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, Mankin H, Hornicek FJ. ZNF93 increases resistance to ET-743 (Trabectedin; Yondelis) and PM00104 (Zalypsis) in human cancer cell lines. PLoS One. 2009; 4(9):e6967.
    View in: PubMed
  36. Yang C, Schwab JH, Schoenfeld AJ, Hornicek FJ, Wood KB, Nielsen GP, Choy E, Mankin H, Duan Z. A novel target for treatment of chordoma: signal transducers and activators of transcription 3. Mol Cancer Ther. 2009 Sep; 8(9):2597-605.
    View in: PubMed
  37. Gonzalez C, Auw Yang KG, Schwab JH, Fitzsimmons JS, Reinholz MM, Resch ZT, Bale LK, Clemens VR, Conover CA, O'Driscoll SW, Reinholz GG. Transforming growth factor-beta1 modulates insulin-like growth factor binding protein-4 expression and proteolysis in cultured periosteal explants. Growth Horm IGF Res. 2010 Apr; 20(2):81-6.
    View in: PubMed
  38. Duan Z, Choy E, Harmon D, Yang C, Ryu K, Schwab J, Mankin H, Hornicek FJ. Insulin-like growth factor-I receptor tyrosine kinase inhibitor cyclolignan picropodophyllin inhibits proliferation and induces apoptosis in multidrug resistant osteosarcoma cell lines. Mol Cancer Ther. 2009 Aug; 8(8):2122-30.
    View in: PubMed
  39. Schwab J, Antonescu C, Boland P, Healey J, Rosenberg A, Nielsen P, Iafrate J, Delaney T, Yoon S, Choy E, Harmon D, Raskin K, Yang C, Mankin H, Springfield D, Hornicek F, Duan Z. Combination of PI3K/mTOR inhibition demonstrates efficacy in human chordoma. Anticancer Res. 2009 Jun; 29(6):1867-71.
    View in: PubMed
  40. Shrader MW, Schwab JH, Shaughnessy WJ, Jacofsky DJ. Pathologic femoral neck fractures in children. Am J Orthop (Belle Mead NJ). 2009 Feb; 38(2):83-6; discussion 86.
    View in: PubMed
  41. Yang C, Hornicek FJ, Wood KB, Schwab JH, Mankin H, Duan Z. RAIDD expression is impaired in multidrug resistant osteosarcoma cell lines. Cancer Chemother Pharmacol. 2009 Aug; 64(3):607-14.
    View in: PubMed
  42. Yang C, Yang S, Wood KB, Hornicek FJ, Schwab JH, Fondren G, Mankin H, Duan Z. Multidrug resistant osteosarcoma cell lines exhibit deficiency of GADD45alpha expression. Apoptosis. 2009 Jan; 14(1):124-33.
    View in: PubMed
  43. Schwab JH, Boland PJ, Agaram NP, Socci ND, Guo T, O'Toole GC, Wang X, Ostroumov E, Hunter CJ, Block JA, Doty S, Ferrone S, Healey JH, Antonescu CR. Chordoma and chondrosarcoma gene profile: implications for immunotherapy. Cancer Immunol Immunother. 2009 Mar; 58(3):339-49.
    View in: PubMed
  44. Heyworth BE, Schwab JH, Boachie-Adjei OB. Case reports: splenic rupture after anterior thoracolumbar spinal fusion through a thoracoabdominal approach. Clin Orthop Relat Res. 2008 Sep; 466(9):2271-5.
    View in: PubMed
  45. Schwab JH, Antonescu CR, Athanasian EA, Boland PJ, Healey JH, Morris CD. A comparison of intramedullary and juxtacortical low-grade osteogenic sarcoma. Clin Orthop Relat Res. 2008 Jun; 466(6):1318-22.
    View in: PubMed
  46. Schwab JH, Healey JH, Athanasian EA. Wide en bloc extra-articular excision of the elbow for sarcoma with complex reconstruction. J Bone Joint Surg Br. 2008 Jan; 90(1):78-83.
    View in: PubMed
  47. Schwab JH, Camacho J, Kaufman K, Chen Q, Berry DJ, Trousdale RT. Optimal fixation for the extended trochanteric osteotomy: a pilot study comparing 3 cables vs 2 cables. J Arthroplasty. 2008 Jun; 23(4):534-8.
    View in: PubMed
  48. Schwab JH, Boland PJ, Antonescu C, Bilsky MH, Healey JH. Spinal metastases from myxoid liposarcoma warrant screening with magnetic resonance imaging. Cancer. 2007 Oct 15; 110(8):1815-22.
    View in: PubMed
  49. Schwab JH, Wenger D, Unni K, Sim FH. Does local recurrence impact survival in low-grade chondrosarcoma of the long bones? Clin Orthop Relat Res. 2007 Sep; 462:175-80.
    View in: PubMed
  50. Schwab JH, Boland P, Guo T, Brennan MF, Singer S, Healey JH, Antonescu CR. Skeletal metastases in myxoid liposarcoma: an unusual pattern of distant spread. Ann Surg Oncol. 2007 Apr; 14(4):1507-14.
    View in: PubMed
  51. Schwab JH, Healey JH. FDG-PET Lacks Sufficient Sensitivity to Detect Myxoid Liposarcoma Spinal Metastases Detected by MRI. Sarcoma. 2007; 2007:36785.
    View in: PubMed
  52. Schwab JH, Athanasian EA, Morris CD, Boland PJ, Healey JH. Function correlates with deltoid preservation in patients having scapular replacement. Clin Orthop Relat Res. 2006 Nov; 452:225-30.
    View in: PubMed
  53. Schwab JH, Agarwal P, Boland PJ, Kennedy JG, Healey JH. Patellar complications following distal femoral replacement after bone tumor resection. J Bone Joint Surg Am. 2006 Oct; 88(10):2225-30.
    View in: PubMed
  54. Schwab JH, Haidukewych GJ, Hanssen AD, Jacofsky DJ, Pagnano MW. Flexion instability without dislocation after posterior stabilized total knees. Clin Orthop Relat Res. 2005 Nov; 440:96-100.
    View in: PubMed
  55. Hymowitz N, Schwab M, McNerney C, Schwab J, Eckholdt H, Haddock K. Postpartum relapse to cigarette smoking in inner city women. J Natl Med Assoc. 2003 Jun; 95(6):461-74.
    View in: PubMed
  56. Schwab JH, Pagnano M, Haidukewych GJ, Trousdale R. A technique for treating periprosthetic fractures of the femur associated with deep prosthetic infection. J Arthroplasty. 2003 Feb; 18(2):211-5.
    View in: PubMed
  57. Ramshaw BJ, Esartia P, Schwab J, Mason EM, Wilson RA, Duncan TD, Miller J, Lucas GW, Promes J. Comparison of laparoscopic and open ventral herniorrhaphy. Am Surg. 1999 Sep; 65(9):827-31; discussion 831-2.
    View in: PubMed
  58. Bachmann G, Bauer T, J├╝rgensen I, Schwab J, Weimar B, Rau WS. [The diagnostic accuracy and therapeutic relevance of CT arthrography and MR arthrography of the shoulder]. Rofo. 1998 Feb; 168(2):149-56.
    View in: PubMed
  59. Cromartie WJ, Craddock JG, Schwab JH, Anderle SK, Yang CH. Arthritis in rats after systemic injection of streptococcal cells or cell walls. J Exp Med. 1977 Dec 1; 146(6):1585-602.
    View in: PubMed
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