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Derin Benerci Keskin, Ph.D.

TitleInstructor in Medicine
InstitutionDana-Farber Cancer Institute
DepartmentMedicine
AddressDana Farber Cancer Institute
Him 421
44 Binney St
Boston MA 02115
Phone671/582-8066
Fax617/632-3351

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhang GL, Riemer AB, Keskin DB, Chitkushev L, Reinherz EL, Brusic V. HPVdb: a data mining system for knowledge discovery in human papillomavirus with applications in T cell immunology and vaccinology. Database (Oxford). 2014; 2014(0):bau031.
    View in: PubMed
  2. Tabansky I, Lenarcic A, Draft RW, Loulier K, Keskin DB, Rosains J, Rivera-Feliciano J, Lichtman JW, Livet J, Stern JN, Sanes JR, Eggan K. Developmental bias in cleavage-stage mouse blastomeres. Curr Biol. 2013 Jan 7; 23(1):21-31.
    View in: PubMed
  3. Cai A, Keskin DB, Deluca DS, Alonso A, Zhang W, Zhang GL, Hammond NN, Nardi V, Stone RM, Neuberg D, Sidney J, Brusic V, Wu CJ. Mutated BCR-ABL Generates Immunogenic T-cell Epitopes in CML Patients. Clin Cancer Res. 2012 Oct 15; 18(20):5761-72.
    View in: PubMed
  4. Lank SM, Golbach BA, Creager HM, Wiseman RW, Keskin DB, Reinherz EL, Brusic V, O'Connor DH. Ultra-high resolution HLA genotyping and allele discovery by highly multiplexed cDNA amplicon pyrosequencing. BMC Genomics. 2012; 13:378.
    View in: PubMed
  5. Riemer AB, Keskin DB, Reinherz EL. Identification and validation of reference genes for expression studies in human keratinocyte cell lines treated with and without interferon-? - a method for qRT-PCR reference gene determination. Exp Dermatol. 2012 Aug; 21(8):625-9.
    View in: PubMed
  6. Olsen LR, Zhang GL, Keskin DB, Reinherz EL, Brusic V. Conservation analysis of dengue virus T-cell epitope-based vaccine candidates using Peptide block entropy. Front Immunol. 2011; 2:69.
    View in: PubMed
  7. Keskin DB, Reinhold B, Lee SY, Zhang G, Lank S, O'Connor DH, Berkowitz RS, Brusic V, Kim SJ, Reinherz EL. Direct identification of an HPV-16 tumor antigen from cervical cancer biopsy specimens. Front Immunol. 2011; 2:75.
    View in: PubMed
  8. DeLuca DS, Keskin DB, Zhang GL, Reinherz EL, Brusic V. PB1-F2 Finder: scanning influenza sequences for PB1-F2 encoding RNA segments. BMC Bioinformatics. 2011 Nov 30; 12 Suppl 13:S6.
    View in: PubMed
  9. Zakka LR, Fradkov E, Keskin DB, Tabansky I, Stern JN, Ahmed AR. The role of natural killer cells in autoimmune blistering diseases. Autoimmunity. 2012 Feb; 45(1):44-54.
    View in: PubMed
  10. Touma M, Keskin DB, Shiroki F, Saito I, Koyasu S, Reinherz EL, Clayton LK. Impaired B cell development and function in the absence of IkappaBNS. J Immunol. 2011 Oct 15; 187(8):3942-52.
    View in: PubMed
  11. Zhang GL, Lin HH, Keskin DB, Reinherz EL, Brusic V. Dana-Farber repository for machine learning in immunology. J Immunol Methods. 2011 Nov 30; 374(1-2):18-25.
    View in: PubMed
  12. Zhang Z, Tongchusak S, Mizukami Y, Kang YJ, Ioji T, Touma M, Reinhold B, Keskin DB, Reinherz EL, Sasada T. Induction of anti-tumor cytotoxic T cell responses through PLGA-nanoparticle mediated antigen delivery. Biomaterials. 2011 May; 32(14):3666-78.
    View in: PubMed
  13. Zhang GL, DeLuca DS, Keskin DB, Chitkushev L, Zlateva T, Lund O, Reinherz EL, Brusic V. MULTIPRED2: a computational system for large-scale identification of peptides predicted to bind to HLA supertypes and alleles. J Immunol Methods. 2011 Nov 30; 374(1-2):53-61.
    View in: PubMed
  14. Zakka LR, Keskin DB, Reche P, Ahmed AR. Relationship between target antigens and major histocompatibility complex (MHC) class II genes in producing two pathogenic antibodies simultaneously. Clin Exp Immunol. 2010 Nov; 162(2):224-36.
    View in: PubMed
  15. Reinhold B, Keskin DB, Reinherz EL. Molecular Detection of Targeted Major Histocompatibility Complex I-Bound Peptides Using a Probabilistic Measure and Nanospray MS(3) on a Hybrid Quadrupole-Linear Ion Trap. Anal Chem. 2010 Nov 1; 82(21):9090-9.
    View in: PubMed
  16. Mabrouk D, Gürcan HM, Keskin DB, Christen WG, Ahmed AR. Association between cancer and immunosuppressive therapy--analysis of selected studies in pemphigus and pemphigoid. Ann Pharmacother. 2010 Nov; 44(11):1770-6.
    View in: PubMed
  17. Stern JN, Keskin DB, Kato Z, Waldner H, Schallenberg S, Anderson A, von Boehmer H, Kretschmer K, Strominger JL. Promoting tolerance to proteolipid protein-induced experimental autoimmune encephalomyelitis through targeting dendritic cells. Proc Natl Acad Sci U S A. 2010 Oct 5; 107(40):17280-5.
    View in: PubMed
  18. Riemer AB, Keskin DB, Zhang G, Handley M, Anderson KS, Brusic V, Reinhold B, Reinherz EL. A conserved E7-derived cytotoxic T lymphocyte epitope expressed on human papillomavirus 16-transformed HLA-A2+ epithelial cancers. J Biol Chem. 2010 Sep 17; 285(38):29608-22.
    View in: PubMed
  19. Bhasin M, Yuan L, Keskin DB, Otu HH, Libermann TA, Oettgen P. Bioinformatic identification and characterization of human endothelial cell-restricted genes. BMC Genomics. 2010; 11:342.
    View in: PubMed
  20. Gürcan HM, Keskin DB, Ahmed AR. Information for healthcare providers on general features of IGIV with emphasis on differences between commercially available products. Autoimmun Rev. 2010 Jun; 9(8):553-9.
    View in: PubMed
  21. Ofran Y, Kim HT, Brusic V, Blake L, Mandrell M, Wu CJ, Sarantopoulos S, Bellucci R, Keskin DB, Soiffer RJ, Antin JH, Ritz J. Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes. Clin Cancer Res. 2010 Mar 1; 16(5):1642-51.
    View in: PubMed
  22. Stern JN, Keskin DB, Romero V, Zuniga J, Encinales L, Li C, Awad C, Yunis EJ. Molecular signatures distinguishing active from latent tuberculosis in peripheral blood mononuclear cells, after in vitro antigenic stimulation with purified protein derivative of tuberculin (PPD) or Candida: a preliminary report. Immunol Res. 2009; 45(1):1-12.
    View in: PubMed
  23. Gürcan HM, Keskin DB, Stern JN, Nitzberg MA, Shekhani H, Ahmed AR. A review of the current use of rituximab in autoimmune diseases. Int Immunopharmacol. 2009 Jan; 9(1):10-25.
    View in: PubMed
  24. Chung J, Serezani CH, Huang SK, Stern JN, Keskin DB, Jagirdar R, Brock TG, Aronoff DM, Peters-Golden M. Rap1 activation is required for Fc gamma receptor-dependent phagocytosis. J Immunol. 2008 Oct 15; 181(8):5501-9.
    View in: PubMed
  25. Stern JN, Keskin DB. Strategies for the identification of loci responsible for the pathogenesis of multiple sclerosis. Cell Mol Biol Lett. 2008; 13(4):656-66.
    View in: PubMed
  26. Stern JN, Keskin DB, Barteneva N, Zuniga J, Yunis EJ, Ahmed AR. Possible role of natural killer cells in pemphigus vulgaris - preliminary observations. Clin Exp Immunol. 2008 Jun; 152(3):472-81.
    View in: PubMed
  27. Stern JN, Keskin DB, Zhang H, Lv H, Kato Z, Strominger JL. Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice. Proc Natl Acad Sci U S A. 2008 Apr 1; 105(13):5172-6.
    View in: PubMed
  28. Keskin DB, Stern JN, Fridkis-Hareli M, Razzaque Ahmed A. Cytokine profiles in pemphigus vulgaris patients treated with intravenous immunoglobulins as compared to conventional immunosuppressive therapy. Cytokine. 2008 Mar; 41(3):315-21.
    View in: PubMed
  29. Touma M, Antonini V, Kumar M, Osborn SL, Bobenchik AM, Keskin DB, Connolly JE, Grusby MJ, Reinherz EL, Clayton LK. Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol. 2007 Aug 1; 179(3):1681-92.
    View in: PubMed
  30. Keskin DB, Allan DS, Rybalov B, Andzelm MM, Stern JN, Kopcow HD, Koopman LA, Strominger JL. TGFbeta promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3378-83.
    View in: PubMed
  31. Keskin DB, Marshall B, Munn D, Mellor AL, Gearhart DA. Decreased protein nitration in macrophages that overexpress indoleamine 2, 3-dioxygenase. Cell Mol Biol Lett. 2007; 12(1):82-102.
    View in: PubMed
  32. Reche PA, Keskin DB, Hussey RE, Ancuta P, Gabuzda D, Reinherz EL. Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes. Med Immunol. 2006; 5:1.
    View in: PubMed
  33. Illes Z, Stern JN, Keskin DB, Reddy J, Brosnan CF, Waldner H, Santambrogio L, Kuchroo VK, Strominger JL. Copolymer effects on microglia and T cells in the central nervous system of humanized mice. Eur J Immunol. 2005 Dec; 35(12):3683-93.
    View in: PubMed
  34. Stern JN, Illés Z, Reddy J, Keskin DB, Fridkis-Hareli M, Kuchroo VK, Strominger JL. Peptide 15-mers of defined sequence that substitute for random amino acid copolymers in amelioration of experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5):1620-5.
    View in: PubMed
  35. Stern JN, Illés Z, Reddy J, Keskin DB, Sheu E, Fridkis-Hareli M, Nishimura H, Brosnan CF, Santambrogio L, Kuchroo VK, Strominger JL. Amelioration of proteolipid protein 139-151-induced encephalomyelitis in SJL mice by modified amino acid copolymers and their mechanisms. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11743-8.
    View in: PubMed
  36. Mellor AL, Munn D, Chandler P, Keskin D, Johnson T, Marshall B, Jhaver K, Baban B. Tryptophan catabolism and T cell responses. Adv Exp Med Biol. 2003; 527:27-35.
    View in: PubMed
  37. Mellor AL, Chandler P, Lee GK, Johnson T, Keskin DB, Lee J, Munn DH. Indoleamine 2,3-dioxygenase, immunosuppression and pregnancy. J Reprod Immunol. 2002 Oct-Nov; 57(1-2):143-50.
    View in: PubMed
  38. Munn DH, Sharma MD, Lee JR, Jhaver KG, Johnson TS, Keskin DB, Marshall B, Chandler P, Antonia SJ, Burgess R, Slingluff CL, Mellor AL. Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. Science. 2002 Sep 13; 297(5588):1867-70.
    View in: PubMed
  39. Mellor AL, Keskin DB, Johnson T, Chandler P, Munn DH. Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses. J Immunol. 2002 Apr 15; 168(8):3771-6.
    View in: PubMed
  40. Fallarino F, Vacca C, Orabona C, Belladonna ML, Bianchi R, Marshall B, Keskin DB, Mellor AL, Fioretti MC, Grohmann U, Puccetti P. Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells. Int Immunol. 2002 Jan; 14(1):65-8.
    View in: PubMed
  41. Marshall B, Keskin DB, Mellor AL. Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme. BMC Biochem. 2001; 2:5.
    View in: PubMed
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