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Last Name
Institution

Atul Malhotra, M.D.

TitleLecturer on Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Pulmonary & Critical Care and Sleep Medicine Divisions
221 Longwood Ave
Boston MA 02115
Phone617/732-5778
Fax617/732-7337

 Biography 
 awards and honors
1992 - 1993Intern of the Year
1993 - 1996Gold Medal Outstanding Achievement for Medical Resident
1993 - 1994Outstanding Teacher of Medical Students
2000 - Trainee Research Merit Award
2001 - 2002Teacher of the Year MGH House Officers
2001 - 2002Teacher of the Year Harvard Pulmonary and Critical Care Fellowship
2005 - Young Investigator Award ATS
2008 - Teaching Appreciation Award from Pulmonary and Critical Care Fellows
2009 - Co-director AASM Program of Distinction
2011 - Member ASCI
2011 - Fellow (FAASM)
2012 - 2013Secretary Treasurer, American Thoracic Society
2013 - 2014Vice President, American Thoracic Society
2015 - President, American Thoracic Society

 Overview 
 overview
My work has helped to change our understanding of the disorder obstructive sleep apnea (OSA) from a single entity into a syndrome with multiple physiological etiologies. This critical expansion in knowledge should allow for the successful individualization of therapy. My group has taken our prior monolithic thinking about OSA elucidated at least three distinct disease pathways. The first, and most obvious, is abnormal upper airway anatomy. We demonstrated that a reduced airway length (from the hard palate to the epiglottis) is a key determinant of predisposition to OSA. Since women having a substantially shorter airway than men (76.1 vs. 58.2 mm, P<0001, independent of body size) this explains for the most part why women suffer from less frequent sleep apnea than men. This work goes beyond simple description, working with bioengineers, we developed a finite element computational model of the human airway that demonstrated the importance of airway length and other anatomical characteristics on OSA. This computational model and experimental measurements also quantified the effecting of aging on airway anatomy and physiology; thus providing a firm biomechanical basis for the previous clinical observations that indicate why OSA is common in the elderly. The second mechanism we have delineated is the control of pharyngeal dilator muscles. We have defined the critical stimuli controlling upper airway muscle activation (negative intrapharyngeal pressure, and C02) and delineated how these mechanisms are affected by sleep and aging. These studies have shown a marked attenuation in the protective airway reflex response to collapsing pressure (R=-0.55, p<0.005) and preferential deposition of fat around the pharyngeal airway, independent of systemic fat. These abnormalities combine to yield a pharyngeal airway which is mechanically unstable and vulnerable to collapse during sleep. One of the key control mechanisms that we have defined was ventilatory control instability (loop gain) which is a metric of the inherent instability in a ventilatory control system. This control system is inherently unstable in an easily definable subgroup of OSA patients. Furthermore, the effect of manipulating loop gain on apnea severity was also demonstrated by my lab making this a novel target for future therapies. We are also working to develop novel methods by which loop gain can be more easily measured in a clinical setting. Third I have shown that sleep state instability (a low arousal threshold to respiratory stimuli) predisposes an individual to cycling ventilation in the wake-sleep transition. That is, some patients develop unstable breathing as a result of an inability to stay asleep, since each arousal leads to marked increases in ventilation and fluctuations in carbon dioxide levels. Thus, the definable subgroup of sleep apnea patients with low arousal threshold may well respond favorably to certain hypnotic medications which will stabilize sleep without impairing respiratory muscles. I have recently completed a pilot clinical trial of hypnotic therapy in carefully selected OSA patients demonstrating clinically and statistically significant improvement in the apnea hypopnea index (Clinical Science (London) 2011) . This work has paved the way to pharmacological therapy for obstructive sleep apnea, one of the keys to moving us beyond CPAP (continuous positive airway pressure) therapy.

More recently, I have begun research involving the cardiovascular complications of sleep disorders, such as sleep apnea. I have received RO1 funding from NHLBI to perform experiments designed to identify those mechanisms important in linking sleep disorders with cardiovascular diseases. This work will help to define the components of sleep apnea that predispose to cardiovascular risk independent of comorbidities such as obesity. This work involves human subjects as well as cell culture and animal models.

My clinical responsibilities include teaching/attending in the Medical Intensive Care Unit, and directing the Clinical Sleep program at BWH. Over the past ten years, I have also attended in the Surgical Intensive Care Unit at BWH, the Medical Intensive Care Unit at MGH, the MICU at the BIDMC and seen patients in the Interstitial Lung Disease Clinic in the Center for Chest Disease at BWH. Most recently in 2012, I have attended in the surgical ICU at King Faisal Hospital in Kigali, Rwanda.

My teaching commitments include co-directing the HST 100 course in Respiratory Physiology and Pathophysiology, small group sessions for New Pathway students at HMS, resident lectures at MGH, BWH and BIDMC approximately once per week, and lecture the Pulmonary and Critical Care Fellows in the Harvard Combined Program on a weekly basis. I was recently director of the annual National Sleep Medicine Course for the AASM. I was also the Chairman of the Education Committee for the American Thoracic Society from 2005-2008. I am immediate past Chairman of the Sleep & Respiratory Neurobiology Assembly of the American Thoracic Society and a current Member of the Board of Directors of the ATS. I am co-director of the American Thoracic Society's Sleep State of the Art Course (SOTA). In total I give approximately 100 lectures per year.

In 2012, I was elected Secretary Treasurer of the American Thoracic Society and will thus be President of the American Thoracic Society in 2015.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bakker JP, Edwards BA, Gautam SP, Montesi SB, Durán-Cantolla J, Barandiarán FA, Barbé F, Sánchez-de-la-Torre M, Malhotra A. Blood Pressure Improvement with Continuous Positive Airway Pressure is Independent of Obstructive Sleep Apnea Severity. J Clin Sleep Med. 2014; 10(4):365-9.
    View in: PubMed
  2. Zhang C, Li Y, Malhotra A, Ning Y, Gao X. Restless legs syndrome status as a predictor for lower physical function. Neurology. 2014 Mar 5.
    View in: PubMed
  3. McSharry DG, Saboisky JP, Deyoung P, Jordan AS, Trinder J, Smales E, Hess L, Chamberlin NL, Malhotra A. Physiological Mechanisms of Upper Airway Hypotonia during REM Sleep. Sleep. 2014; 37(3):561-9.
    View in: PubMed
  4. Bakker JP, Campana LM, Montesi SB, Balachandran J, Deyoung PN, Smales E, Patel SR, Malhotra A. A pilot study investigating the effects of continuous positive airway pressure treatment and weight-loss surgery on autonomic activity in obese obstructive sleep apnea patients. J Electrocardiol. 2014 Feb 27.
    View in: PubMed
  5. Teodorescu M, Xie A, Sorkness CA, Robbins J, Reeder S, Gong Y, Fedie JE, Sexton A, Miller B, Huard T, Hind J, Bioty N, Peterson E, Kunselman SJ, Chinchilli VM, Soler X, Ramsdell J, Loredo J, Israel E, Eckert DJ, Malhotra A. Effects of Inhaled Fluticasone on Upper Airway during Sleep and Wakefulness in Asthma: A Pilot Study. J Clin Sleep Med. 2014; 10(2):183-93.
    View in: PubMed
  6. Eckert DJ, White DP, Jordan AS, Malhotra A, Wellman A. Reply: arousal threshold in obstructive sleep apnea. Am J Respir Crit Care Med. 2014 Feb 1; 189(3):373-4.
    View in: PubMed
  7. Djonlagic I, Guo M, Matteis P, Carusona A, Stickgold R, Malhotra A. Untreated sleep-disordered breathing: links to aging-related decline in sleep-dependent memory consolidation. PLoS One. 2014; 9(1):e85918.
    View in: PubMed
  8. Owens RL, Edwards BA, Sands SA, Butler JP, Eckert DJ, White DP, Malhotra A, Wellman A. The classical Starling Resistor model often does not predict inspiratory airflow patterns in the human upper airway. J Appl Physiol (1985). 2014 Jan 23.
    View in: PubMed
  9. Beitler JR, Shaefi S, Montesi SB, Devlin A, Loring SH, Talmor D, Malhotra A. Prone positioning reduces mortality from acute respiratory distress syndrome in the low tidal volume era: a meta-analysis. Intensive Care Med. 2014 Jan 17.
    View in: PubMed
  10. Malhotra A. Hypoglossal-nerve stimulation for obstructive sleep apnea. N Engl J Med. 2014 Jan 9; 370(2):170-1.
    View in: PubMed
  11. Roebuck A, Monasterio V, Gederi E, Osipov M, Behar J, Malhotra A, Penzel T, Clifford GD. A review of signals used in sleep analysis. Physiol Meas. 2014 Jan; 35(1):R1-R57.
    View in: PubMed
  12. Lower EE, Malhotra A, Sudurlescu V, Baughman RP. Sarcoidosis, fatigue, and sleep apnea. Chest. 2013 Dec 1; 144(6):1976-7.
    View in: PubMed
  13. Smith RS, Efron B, Mah CD, Malhotra A. The impact of circadian misalignment on athletic performance in professional football players. Sleep. 2013; 36(12):1999-2001.
    View in: PubMed
  14. Neilan TG, Farhad H, Dodson JA, Shah RV, Abbasi SA, Bakker JP, Michaud GF, van der Geest R, Blankstein R, Steigner M, John RM, Jerosch-Herold M, Malhotra A, Kwong RY. Effect of sleep apnea and continuous positive airway pressure on cardiac structure and recurrence of atrial fibrillation. J Am Heart Assoc. 2013; 2(6):e000421.
    View in: PubMed
  15. Carson SS, Goss CH, Patel SR, Anzueto A, Au DH, Elborn S, Gerald JK, Gerald LB, Kahn JM, Malhotra A, A Mularski R, A Riekert K, D Rubenfeld G, E Weaver T, Krishnan JA. An official american thoracic society research statement: comparative effectiveness research in pulmonary, critical care, and sleep medicine. Am J Respir Crit Care Med. 2013 Nov 15; 188(10):1253-61.
    View in: PubMed
  16. Montesi SB, Bakker JP, Macdonald M, Hueser L, Pittman S, White DP, Malhotra A. Air Leak during CPAP Titration as a Risk Factor for Central Apnea. J Clin Sleep Med. 2013; 9(11):1187-91.
    View in: PubMed
  17. Deyoung PN, Bakker JP, Sands SA, Batool-Anwar S, Connolly JG, Butler JP, Malhotra A. Acoustic pharyngometry measurement of minimal cross-sectional airway area is a significant independent predictor of moderate-to-severe obstructive sleep apnea. J Clin Sleep Med. 2013; 9(11):1161-4.
    View in: PubMed
  18. Sarge T, Loring SH, Yitsak-Sade M, Malhotra A, Novack V, Talmor D. Raising positive end-expiratory pressures in ARDS to achieve a positive transpulmonary pressure does not cause hemodynamic compromise. Intensive Care Med. 2014 Jan; 40(1):126-8.
    View in: PubMed
  19. Eckert DJ, White DP, Jordan AS, Malhotra A, Wellman A. Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. Am J Respir Crit Care Med. 2013 Oct 15; 188(8):996-1004.
    View in: PubMed
  20. Kezirian EJ, Goding GS, Malhotra A, O'Donoghue FJ, Zammit G, Wheatley JR, Catcheside PG, Smith PL, Schwartz AR, Walsh JH, Maddison KJ, Claman DM, Huntley T, Park SY, Campbell MC, Palme CE, Iber C, Eastwood PR, Hillman DR, Barnes M. Hypoglossal nerve stimulation improves obstructive sleep apnea: 12-month outcomes. J Sleep Res. 2014 Feb; 23(1):77-83.
    View in: PubMed
  21. Schwab RJ, Badr SM, Epstein LJ, Gay PC, Gozal D, Kohler M, Lévy P, Malhotra A, Phillips BA, Rosen IM, Strohl KP, Strollo PJ, Weaver EM, Weaver TE. An official american thoracic society statement: continuous positive airway pressure adherence tracking systems. The optimal monitoring strategies and outcome measures in adults. Am J Respir Crit Care Med. 2013 Sep 1; 188(5):613-20.
    View in: PubMed
  22. Bakker JP, Balachandran JS, Tecilazich F, Deyoung PN, Smales E, Veves A, Malhotra A. Pilot study of the effects of bariatric surgery and continuous positive airway pressure treatment on vascular function in obese subjects with obstructive sleep apnoea. Intern Med J. 2013 Sep; 43(9):993-8.
    View in: PubMed
  23. Horner RL, Hughes SW, Malhotra A. State-Dependent and Reflex Drives to the Upper Airway: Basic Physiology with Clinical Implication. J Appl Physiol. 2013 Aug 22.
    View in: PubMed
  24. Shaw ND, Goodwin JL, Silva GE, Hall JE, Quan SF, Malhotra A. Obstructive Sleep Apnea (OSA) in Preadolescent Girls is Associated with Delayed Breast Development Compared to Girls without OSA. J Clin Sleep Med. 2013; 9(8):813-8.
    View in: PubMed
  25. Stanchina ML, Welicky LM, Donat W, Lee D, Corrao W, Malhotra A. Impact of CPAP Use and Age on Mortality in Patients with Combined COPD and Obstructive Sleep Apnea: The Overlap Syndrome. J Clin Sleep Med. 2013; 9(8):767-72.
    View in: PubMed
  26. Jordan AS, McSharry DG, Malhotra A. Adult obstructive sleep apnoea. Lancet. 2013 Aug 1.
    View in: PubMed
  27. Zhang C, Berger M, Malhotra A, Kales S. Portable diagnostic devices and commercial motor vehicle drivers. Sleep. 2013; 36(8):1263-4.
    View in: PubMed
  28. Edwards BA, Malhotra A, Sands SA. Adapting our approach to treatment-emergent central sleep apnea. Sleep. 2013; 36(8):1121-2.
    View in: PubMed
  29. Kaczmarek E, Bakker JP, Clarke DN, Csizmadia E, Kocher O, Veves A, Tecilazich F, O'Donnell CP, Ferran C, Malhotra A. Molecular biomarkers of vascular dysfunction in obstructive sleep apnea. PLoS One. 2013; 8(7):e70559.
    View in: PubMed
  30. Colrain IM, Black J, Siegel LC, Bogan RK, Becker PM, Farid-Moayer M, Goldberg R, Lankford DA, Goldberg AN, Malhotra A. A multicenter evaluation of oral pressure therapy for the treatment of obstructive sleep apnea. Sleep Med. 2013 Sep; 14(9):830-7.
    View in: PubMed
  31. Ayas NT, Malhotra A, Parthsarathy S. To Sleep, or Not to Sleep, That is the Question*. Crit Care Med. 2013 Jul; 41(7):1808-10.
    View in: PubMed
  32. Lehman LW, Nemati S, Adams RP, Moody G, Malhotra A, Mark RG. Tracking progression of patient state of health in critical care using inferred shared dynamics in physiological time series. Conf Proc IEEE Eng Med Biol Soc. 2013 Jul; 2013:7072-5.
    View in: PubMed
  33. Nemati S, Edwards BA, Lee J, Pittman-Polletta B, Butler JP, Malhotra A. Respiration and heart rate complexity: Effects of age and gender assessed by band-limited transfer entropy. Respir Physiol Neurobiol. 2013 Oct 1; 189(1):27-33.
    View in: PubMed
  34. Li Y, Wang W, Winkelman JW, Malhotra A, Ma J, Gao X. Prospective study of restless legs syndrome and mortality among men. Neurology. 2013 Jul 2; 81(1):52-9.
    View in: PubMed
  35. Ginosar Y, Malhotra A, Schwartz E. High altitude, continuous positive airway pressure, and obstructive sleep apnea: subjective observations and objective data. High Alt Med Biol. 2013 Jun; 14(2):186-9.
    View in: PubMed
  36. Chesson AL, Chervin RD, Benca RM, Greenough GP, O'Hearn DJ, Auckley DH, Littner M, Mullington JM, Malhotra A, Berry RB, Malhotra RK, Schulman DA. Organization and structure for sleep medicine programs at academic institutions: part 2-goals and strategies to optimize patient care, education, and discovery. Sleep. 2013; 36(6):803-11.
    View in: PubMed
  37. Chervin RD, Chesson AL, Benca RM, Greenough GP, O'Hearn DJ, Auckley DH, Littner M, Mullington JM, Malhotra A, Berry RB, Malhotra RK, Schulman DA. Organization and structure for sleep medicine programs at academic institutions: part 1-current challenges. Sleep. 2013; 36(6):795-801.
    View in: PubMed
  38. Beitler JR, Hubmayr RD, Malhotra A. Rebuttal from jeremy R. Beitler, rolf d. Hubmayr and atul malhotra. J Physiol. 2013 Jun 1; 591(Pt 11):2773.
    View in: PubMed
  39. Beitler JR, Hubmayr RD, Malhotra A. CrossTalk opposing view: There is not added benefit to providing permissive hypercapnia in the treatment of ARDS. J Physiol. 2013 Jun 1; 591(Pt 11):2767-9.
    View in: PubMed
  40. Strohl KP, Brown DB, Collop N, George C, Grunstein R, Han F, Kline L, Malhotra A, Pack A, Phillips B, Rodenstein D, Schwab R, Weaver T, Wilson K. An official american thoracic society clinical practice guideline: sleep apnea, sleepiness, and driving risk in noncommercial drivers. Am J Respir Crit Care Med. 2013 Jun 1; 187(11):1259-66.
    View in: PubMed
  41. Kohli P, Sarmiento K, Malhotra A. Update in sleep medicine 2012. Am J Respir Crit Care Med. 2013 May 15; 187(10):1056-60.
    View in: PubMed
  42. Plataki M, Sands SA, Malhotra A. Clinical consequences of altered chemoreflex control. Respir Physiol Neurobiol. 2013 Nov 1; 189(2):354-63.
    View in: PubMed
  43. Butler JP, Owens RL, Malhotra A, Wellman A. Rebuttal from james p. Butler, robert L. Owens, atul malhotra and andrew wellman. J Physiol. 2013 May 1; 591(Pt 9):2237.
    View in: PubMed
  44. Butler JP, Owens RL, Malhotra A, Wellman A. CrossTalk opposing view: The human upper airway during sleep does not behave like a Starling resistor. J Physiol. 2013 May 1; 591(Pt 9):2233-4.
    View in: PubMed
  45. McSharry DG, Saboisky JP, Deyoung P, Matteis P, Jordan AS, Trinder J, Smales E, Hess L, Guo M, Malhotra A. A Mechanism for Upper Airway Stability during Slow Wave Sleep. Sleep. 2013; 36(4):555-63.
    View in: PubMed
  46. Malhotra A, Younes M, Kuna ST, Benca R, Kushida CA, Walsh J, Hanlon A, Staley B, Pack AI, Pien GW. Performance of an automated polysomnography scoring system versus computer-assisted manual scoring. Sleep. 2013; 36(4):573-82.
    View in: PubMed
  47. Chang SY, Dabbagh O, Gajic O, Patrawalla A, Elie MC, Talmor DS, Malhotra A, Adesanya A, Anderson HL, Blum JM, Park PK, Gong MN. Contemporary Ventilator Management in Patients With and at Risk of ALI/ARDS. Respir Care. 2013 Apr; 58(4):578-88.
    View in: PubMed
  48. Kuna ST, Benca R, Kushida CA, Walsh J, Younes M, Staley B, Hanlon A, Pack AI, Pien GW, Malhotra A. Agreement in Computer-Assisted Manual Scoring of Polysomnograms across Sleep Centers. Sleep. 2013; 36(4):583-9.
    View in: PubMed
  49. Campana LM, Owens RL, Butler JP, Suki B, Malhotra A. Variability of respiratory mechanics during sleep in overweight and obese subjects with and without asthma. Respir Physiol Neurobiol. 2013 May 1; 186(3):290-5.
    View in: PubMed
  50. Edwards BA, Connolly JG, Campana LM, Sands SA, Trinder JA, White DP, Wellman A, Malhotra A. Acetazolamide attenuates the ventilatory response to arousal in patients with obstructive sleep apnea. Sleep. 2013; 36(2):281-5.
    View in: PubMed
  51. Wellman A, Edwards BA, Sands SA, Owens RL, Nemati S, Butler J, Passaglia CL, Jackson AC, Malhotra A, White DP. A simplified method for determining phenotypic traits in patients with obstructive sleep apnea. J Appl Physiol. 2013 Apr; 114(7):911-22.
    View in: PubMed
  52. Malhotra A, Drazen JM. High-frequency oscillatory ventilation on shaky ground. N Engl J Med. 2013 Feb 28; 368(9):863-5.
    View in: PubMed
  53. Bakker JP, Montesi SB, Malhotra A. Obstructive sleep apnoea: new associations and approaches. Lancet Respir Med. 2013 Mar; 1(1):e15-6.
    View in: PubMed
  54. Sligl WI, Hoang H, Eurich DT, Malhotra A, Marrie TJ, Majumdar SR. Macrolide use in the treatment of critically ill patients with pneumonia: Incidence, correlates, timing and outcomes. Can J Infect Dis Med Microbiol. 2013; 24(4):e107-12.
    View in: PubMed
  55. Shaikh ZF, Jaye J, Ward N, Malhotra A, de Villa M, Polkey MI, Mullen MJ, Morrell MJ. Patent foramen ovale in severe obstructive sleep apnea: clinical features and effects of closure. Chest. 2013 Jan; 143(1):56-63.
    View in: PubMed
  56. Lehman LW, Saeed M, Talmor D, Mark R, Malhotra A. Methods of Blood Pressure Measurement in the ICU*. Crit Care Med. 2013 Jan; 41(1):34-40.
    View in: PubMed
  57. Sharma B, Neilan TG, Kwong RY, Mandry D, Owens RL, McSharry D, Bakker JP, Malhotra A. Evaluation of right ventricular remodeling using cardiac magnetic resonance imaging in co-existent chronic obstructive pulmonary disease and obstructive sleep apnea. COPD. 2013 Feb; 10(1):4-10.
    View in: PubMed
  58. Hayes SM, Murray S, Castriotta RJ, Landrigan CP, Malhotra A. (Mis) perceptions and interactions of sleep specialists and generalists: obstacles to referrals to sleep specialists and the multidisciplinary team management of sleep disorders. J Clin Sleep Med. 2012; 8(6):633-42.
    View in: PubMed
  59. Mandelbaum T, Lee J, Scott DJ, Mark RG, Malhotra A, Howell MD, Talmor D. Empirical relationships among oliguria, creatinine, mortality, and renal replacement therapy in the critically ill. Intensive Care Med. 2013 Mar; 39(3):414-9.
    View in: PubMed
  60. Weiss JP, Jumadilova Z, Johnson TM, Fitzgerald MP, Carlsson M, Martire DL, Malhotra A. Efficacy and safety of flexible dose fesoterodine in men and women with overactive bladder symptoms including nocturnal urinary urgency. J Urol. 2013 Apr; 189(4):1396-401.
    View in: PubMed
  61. Sharma BK, Bakker JP, McSharry DG, Desai AS, Javaheri S, Malhotra A. Adaptive servoventilation for treatment of sleep-disordered breathing in heart failure: a systematic review and meta-analysis. Chest. 2012 Nov; 142(5):1211-21.
    View in: PubMed
  62. Zhang C, Berger M, Malhotra A, Kales SN. Portable Diagnostic Devices for Identifying Obstructive Sleep Apnea among Commercial Motor Vehicle Drivers: Considerations and Unanswered Questions. Sleep. 2012; 35(11):1481-9.
    View in: PubMed
  63. Montesi SB, Edwards BA, Malhotra A, Bakker JP. The effect of continuous positive airway pressure treatment on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Clin Sleep Med. 2012; 8(5):587-96.
    View in: PubMed
  64. Campana LM, Malhotra A, Suki B, Hess L, Israel E, Smales E, Deyoung P, Owens RL. The effect of lung stretch during sleep on airway mechanics in overweight and obese asthma. Respir Physiol Neurobiol. 2013 Jan 15; 185(2):304-12.
    View in: PubMed
  65. Scheer FA, Morris CJ, Garcia JI, Smales C, Kelly EE, Marks J, Malhotra A, Shea SA. Repeated melatonin supplementation improves sleep in hypertensive patients treated with beta-blockers: a randomized controlled trial. Sleep. 2012; 35(10):1395-402.
    View in: PubMed
  66. Kahlon S, Eurich DT, Padwal RS, Malhotra A, Minhas-Sandhu JK, Marrie TJ, Majumdar SR. Obesity and outcomes in patients hospitalized with pneumonia. Clin Microbiol Infect. 2013 Aug; 19(8):709-16.
    View in: PubMed
  67. Hibbert K, Rice M, Malhotra A. Obesity and ARDS. Chest. 2012 Sep; 142(3):785-90.
    View in: PubMed
  68. Lower EE, Malhotra A, Surdulescu V, Baughman RP. Armodafinil for sarcoidosis-associated fatigue: a double-blind, placebo-controlled, crossover trial. J Pain Symptom Manage. 2013 Feb; 45(2):159-69.
    View in: PubMed
  69. Nemati S, Lehman LW, Adams RP, Malhotra A. Discovering shared cardiovascular dynamics within a patient cohort. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012:6526-9.
    View in: PubMed
  70. Berger M, Varvarigou V, Rielly A, Czeisler CA, Malhotra A, Kales SN. Employer-mandated sleep apnea screening and diagnosis in commercial drivers. J Occup Environ Med. 2012 Aug; 54(8):1017-25.
    View in: PubMed
  71. Li Y, Mirzaei F, O'Reilly EJ, Winkelman J, Malhotra A, Okereke OI, Ascherio A, Gao X. Prospective study of restless legs syndrome and risk of depression in women. Am J Epidemiol. 2012 Aug 15; 176(4):279-88.
    View in: PubMed
  72. Montesi SB, Bajwa EK, Malhotra A. Biomarkers of sleep apnea. Chest. 2012 Jul; 142(1):239-45.
    View in: PubMed
  73. Strohl KP, Butler JP, Malhotra A. Mechanical properties of the upper airway. Compr Physiol. 2012 Jul 1; 2(3):1853-72.
    View in: PubMed
  74. Altintas N, Aslan E, Helvaci A, Malhotra A. Relationship between obstructive sleep apnea severity index and left ventricular function and volume. Ann Saudi Med. 2012 Jul-Aug; 32(4):384-90.
    View in: PubMed
  75. Malhotra A, Butler JP, Wellman A. The pharyngeal airway: is bigger really better? Chest. 2012 Jun; 141(6):1372-5.
    View in: PubMed
  76. Pulliam SJ, Weinstein DF, Malhotra A, Macklin EA, Berkowitz LR. Baseline sleep dysfunction among matriculating interns. J Grad Med Educ. 2012 Jun; 4(2):202-8.
    View in: PubMed
  77. Owens RL, Edwards BA, Sands SA, Butler JP, Eckert DJ, White DP, Malhotra A, Wellman A. Upper airway collapsibility and patterns of flow limitation at constant end-expiratory lung volume. J Appl Physiol. 2012 Sep 1; 113(5):691-9.
    View in: PubMed
  78. Owens RL, Campana LM, Hess L, Eckert DJ, Loring SH, Malhotra A. Sitting and supine esophageal pressures in overweight and obese subjects. Obesity (Silver Spring). 2012 Dec; 20(12):2354-60.
    View in: PubMed
  79. Awad KM, Malhotra A, Barnet JH, Quan SF, Peppard PE. Exercise is associated with a reduced incidence of sleep-disordered breathing. Am J Med. 2012 May; 125(5):485-90.
    View in: PubMed
  80. Nicholas CL, Jordan AS, Heckel L, Worsnop C, Bei B, Saboisky JP, Eckert DJ, White DP, Malhotra A, Trinder J. Discharge patterns of human tensor palatini motor units during sleep onset. Sleep. 2012 May; 35(5):699-707.
    View in: PubMed
  81. Owens RL, Edwards BA, Malhotra A, Wellman A. Expiratory resistance increases end-expiratory lung volume during sleep. Am J Respir Crit Care Med. 2012 Apr 15; 185(8):e10-1.
    View in: PubMed
  82. Lee J, Nemati S, Silva I, Edwards BA, Butler JP, Malhotra A. Transfer entropy estimation and directional coupling change detection in biomedical time series. Biomed Eng Online. 2012; 11:19.
    View in: PubMed
  83. Djonlagic I, Saboisky J, Carusona A, Stickgold R, Malhotra A. Increased sleep fragmentation leads to impaired off-line consolidation of motor memories in humans. PLoS One. 2012; 7(3):e34106.
    View in: PubMed
  84. Novack V, MacFadyen J, Malhotra A, Almog Y, Glynn RJ, Ridker PM. The effect of rosuvastatin on incident pneumonia: results from the JUPITER trial. CMAJ. 2012 Apr 17; 184(7):E367-72.
    View in: PubMed
  85. Bakker JP, Sharma B, Malhotra A. Obstructive sleep apnea: the elephant in the cardiovascular room. Chest. 2012 Mar; 141(3):580-1.
    View in: PubMed
  86. Zhang C, Varvarigou V, Parks PD, Gautam S, Bueno AV, Malhotra A, Kales SN. Psychomotor vigilance testing of professional drivers in the occupational health clinic: a potential objective screen for daytime sleepiness. J Occup Environ Med. 2012 Mar; 54(3):296-302.
    View in: PubMed
  87. Engelberts D, Malhotra A, Butler JP, Topulos GP, Loring SH, Kavanagh BP. Relative effects of negative versus positive pressure ventilation depend on applied conditions. Intensive Care Med. 2012 May; 38(5):879-85.
    View in: PubMed
  88. Powell ED, Gay PC, Ojile JM, Litinski M, Malhotra A. A pilot study assessing adherence to auto-bilevel following a poor initial encounter with CPAP. J Clin Sleep Med. 2012 Feb 15; 8(1):43-7.
    View in: PubMed
  89. Awad KM, Drescher AA, Malhotra A, Quan SF. Effects of exercise and nutritional intake on sleep architecture in adolescents. Sleep Breath. 2013 Mar; 17(1):117-24.
    View in: PubMed
  90. Edwards BA, Sands SA, Eckert DJ, White DP, Butler JP, Owens RL, Malhotra A, Wellman A. Acetazolamide improves loop gain but not the other physiological traits causing obstructive sleep apnoea. J Physiol. 2012 Mar 1; 590(Pt 5):1199-211.
    View in: PubMed
  91. Patel SR, Malhotra A, Gao X, Hu FB, Neuman MI, Fawzi WW. A prospective study of sleep duration and pneumonia risk in women. Sleep. 2012 Jan; 35(1):97-101.
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  92. Schwartz AR, Barnes M, Hillman D, Malhotra A, Kezirian E, Smith PL, Hoegh T, Parrish D, Eastwood PR. Acute upper airway responses to hypoglossal nerve stimulation during sleep in obstructive sleep apnea. Am J Respir Crit Care Med. 2012 Feb 15; 185(4):420-6.
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  93. Sharma B, McSharry D, Malhotra A. Sleep disordered breathing in patients with heart failure: pathophysiology and management. Curr Treat Options Cardiovasc Med. 2011 Dec; 13(6):506-16.
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  94. Mandelbaum T, Scott DJ, Lee J, Mark RG, Malhotra A, Waikar SS, Howell MD, Talmor D. Outcome of critically ill patients with acute kidney injury using the Acute Kidney Injury Network criteria. Crit Care Med. 2011 Dec; 39(12):2659-64.
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  95. Campana LM, Owens RL, Suki B, Malhotra A. Measuring upper and lower airway resistance during sleep with the forced oscillation technique. Ann Biomed Eng. 2012 Apr; 40(4):925-33.
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  96. Cao Y, McGuire M, Liu C, Malhotra A, Ling L. Phasic respiratory modulation of pharyngeal collapsibility via neuromuscular mechanisms in rats. J Appl Physiol. 2012 Mar; 112(5):695-703.
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  97. Eastwood PR, Barnes M, Walsh JH, Maddison KJ, Hee G, Schwartz AR, Smith PL, Malhotra A, McEvoy RD, Wheatley JR, O'Donoghue FJ, Rochford PD, Churchward T, Campbell MC, Palme CE, Robinson S, Goding GS, Eckert DJ, Jordan AS, Catcheside PG, Tyler L, Antic NA, Worsnop CJ, Kezirian EJ, Hillman DR. Treating obstructive sleep apnea with hypoglossal nerve stimulation. Sleep. 2011 Nov; 34(11):1479-86.
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  98. Varvarigou V, Dahabreh IJ, Malhotra A, Kales SN. A review of genetic association studies of obstructive sleep apnea: field synopsis and meta-analysis. Sleep. 2011 Nov; 34(11):1461-8.
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  99. Saboisky JP, Stashuk DW, Hamilton-Wright A, Carusona AL, Campana LM, Trinder J, Eckert DJ, Jordan AS, McSharry DG, White DP, Nandedkar S, David WS, Malhotra A. Neurogenic changes in the upper airway of patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2012 Feb 1; 185(3):322-9.
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  100. Batool-Anwar S, Malhotra A, Forman J, Winkelman J, Li Y, Gao X. Restless legs syndrome and hypertension in middle-aged women. Hypertension. 2011 Nov; 58(5):791-6.
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  101. Balachandran JS, Bakker JP, Rahangdale S, Yim-Yeh S, Mietus JE, Goldberger AL, Malhotra A. Effect of mild, asymptomatic obstructive sleep apnea on daytime heart rate variability and impedance cardiography measurements. Am J Cardiol. 2012 Jan 1; 109(1):140-5.
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  102. Eckert DJ, Lo YL, Saboisky JP, Jordan AS, White DP, Malhotra A. Sensorimotor function of the upper-airway muscles and respiratory sensory processing in untreated obstructive sleep apnea. J Appl Physiol. 2011 Dec; 111(6):1644-53.
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  103. Bertisch SM, Schomer A, Kelly EE, Baloa LA, Hueser LE, Pittman SD, Malhotra A. Device-guided paced respiration as an adjunctive therapy for hypertension in obstructive sleep apnea: a pilot feasibility study. Appl Psychophysiol Biofeedback. 2011 Sep; 36(3):173-9.
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  104. Genta PR, Eckert DJ, Gregorio MG, Danzi NJ, Moriya HT, Malhotra A, Lorenzi-Filho G. Critical closing pressure during midazolam-induced sleep. J Appl Physiol. 2011 Nov; 111(5):1315-22.
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  105. Campana LM, Clifford GD, Trinder J, Pittman SD, Malhotra A. A possible method to predict response to non-pharmacological insomnia therapy. J Clin Sleep Med. 2011 Aug 15; 7(4):370-5.
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  106. Jordan AS, Eckert DJ, Wellman A, Trinder JA, Malhotra A, White DP. Termination of respiratory events with and without cortical arousal in obstructive sleep apnea. Am J Respir Crit Care Med. 2011 Nov 15; 184(10):1183-91.
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  107. Hedner J, White DP, Malhotra A, Herscovici S, Pittman SD, Zou D, Grote L, Pillar G. Sleep staging based on autonomic signals: a multi-center validation study. J Clin Sleep Med. 2011 Jun 15; 7(3):301-6.
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  108. Eckert DJ, Owens RL, Kehlmann GB, Wellman A, Rahangdale S, Yim-Yeh S, White DP, Malhotra A. Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold. Clin Sci (Lond). 2011 Jun; 120(12):505-14.
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  109. Sundar S, Novack V, Jervis K, Bender SP, Lerner A, Panzica P, Mahmood F, Malhotra A, Talmor D. Influence of low tidal volume ventilation on time to extubation in cardiac surgical patients. Anesthesiology. 2011 May; 114(5):1102-10.
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  110. Rahangdale S, Yeh SY, Novack V, Stevenson K, Barnard MR, Furman MI, Frelinger AL, Michelson AD, Malhotra A. The influence of intermittent hypoxemia on platelet activation in obese patients with obstructive sleep apnea. J Clin Sleep Med. 2011 Apr 15; 7(2):172-8.
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  111. Nemati S, Edwards BA, Sands SA, Berger PJ, Wellman A, Verghese GC, Malhotra A, Butler JP. Model-based characterization of ventilatory stability using spontaneous breathing. J Appl Physiol. 2011 Jul; 111(1):55-67.
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  112. Kohli P, Balachandran JS, Malhotra A. Obstructive sleep apnea and the risk for cardiovascular disease. Curr Atheroscler Rep. 2011 Apr; 13(2):138-46.
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  113. Wellman A, Eckert DJ, Jordan AS, Edwards BA, Passaglia CL, Jackson AC, Gautam S, Owens RL, Malhotra A, White DP. A method for measuring and modeling the physiological traits causing obstructive sleep apnea. J Appl Physiol. 2011 Jun; 110(6):1627-37.
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  114. Owens RL, Wellman A, Malhotra A. Which OSA Patients Might Respond to Nasal Valves? J Clin Sleep Med. 2011 Feb 15; 7(1):23-4.
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  115. Mostafiz W, Dalci O, Sutherland K, Malhotra A, Srinivasan V, Darendeliler MA, Cistulli PA. Influence of oral and craniofacial dimensions on mandibular advancement splint treatment outcome in patients with obstructive sleep apnea. Chest. 2011 Jun; 139(6):1331-9.
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  116. Shih JL, Malhotra A. Could vitamins be helpful to patients with sleep apnea? Chest. 2011 Feb; 139(2):237-8.
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  117. Ferreira JC, Benseñor FE, Rocha MJ, Salge JM, Harris RS, Malhotra A, Kairalla RA, Kacmarek RM, Carvalho CR. A sigmoidal fit for pressure-volume curves of idiopathic pulmonary fibrosis patients on mechanical ventilation: clinical implications. Clinics (Sao Paulo). 2011; 66(7):1157-63.
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  118. Nemati S, Malhotra A, Clifford GD. T-wave alternans patterns during sleep in healthy, cardiac disease, and sleep apnea patients. J Electrocardiol. 2011 Mar-Apr; 44(2):126-30.
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  119. Sharma B, Feinsilver S, Owens RL, Malhotra A, McSharry D, Karbowitz S. Obstructive airway disease and obstructive sleep apnea: effect of pulmonary function. Lung. 2011 Feb; 189(1):37-41.
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  120. Scheer FA, Hu K, Evoniuk H, Kelly EE, Malhotra A, Hilton MF, Shea SA. Impact of the human circadian system, exercise, and their interaction on cardiovascular function. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20541-6.
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  121. Nicholas CL, Bei B, Worsnop C, Malhotra A, Jordan AS, Saboisky JP, Chan JK, Duckworth E, White DP, Trinder J. Motor unit recruitment in human genioglossus muscle in response to hypercapnia. Sleep. 2010 Nov; 33(11):1529-38.
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  122. Saboisky JP, Jordan AS, Eckert DJ, White DP, Trinder JA, Nicholas CL, Gautam S, Malhotra A. Recruitment and rate-coding strategies of the human genioglossus muscle. J Appl Physiol. 2010 Dec; 109(6):1939-49.
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  123. Edwards BA, O'Driscoll DM, Ali A, Jordan AS, Trinder J, Malhotra A. Aging and sleep: physiology and pathophysiology. Semin Respir Crit Care Med. 2010 Oct; 31(5):618-33.
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  124. Owens RL, Malhotra A. Sleep-disordered breathing and COPD: the overlap syndrome. Respir Care. 2010 Oct; 55(10):1333-44; discussion 1344-6.
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  125. Torelli F, Moscufo N, Garreffa G, Placidi F, Romigi A, Zannino S, Bozzali M, Fasano F, Giulietti G, Djonlagic I, Malhotra A, Marciani MG, Guttmann CR. Cognitive profile and brain morphological changes in obstructive sleep apnea. Neuroimage. 2011 Jan 15; 54(2):787-93.
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  126. Liu C, Cao Y, Malhotra A, Ling L. Sleep fragmentation attenuates the hypercapnic (but not hypoxic) ventilatory responses via adenosine A1 receptors in awake rats. Respir Physiol Neurobiol. 2011 Jan 31; 175(1):29-36.
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  127. Doupis J, Rahangdale S, Gnardellis C, Pena SE, Malhotra A, Veves A. Effects of diabetes and obesity on vascular reactivity, inflammatory cytokines, and growth factors. Obesity (Silver Spring). 2011 Apr; 19(4):729-35.
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  128. Peer A, Lorber A, Suraiya S, Malhotra A, Pillar G. The occurrence of cheyne-stokes respiration in congestive heart failure: the effect of age. Front Psychiatry. 2010; 1:133.
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  129. Malhotra A, Owens RL. What is central sleep apnea? Respir Care. 2010 Sep; 55(9):1168-78.
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  130. Yim-Yeh S, Rahangdale S, Nguyen AT, Jordan AS, Novack V, Veves A, Malhotra A. Obstructive sleep apnea and aging effects on macrovascular and microcirculatory function. Sleep. 2010 Sep; 33(9):1177-83.
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  131. Krystal AD, Zammit GK, Wyatt JK, Quan SF, Edinger JD, White DP, Chiacchierini RP, Malhotra A. The effect of vestibular stimulation in a four-hour sleep phase advance model of transient insomnia. J Clin Sleep Med. 2010 Aug 15; 6(4):315-21.
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  132. Djonlagic I, Malhotra A. Risk of stroke from sleep apnea in men and women. Expert Rev Neurother. 2010 Aug; 10(8):1267-71.
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  133. Kezirian EJ, Malhotra A, Goldberg AN, White DP. Changes in obstructive sleep apnea severity, biomarkers, and quality of life after multilevel surgery. Laryngoscope. 2010 Jul; 120(7):1481-8.
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  134. Yim-Yeh S, Rahangdale S, Nguyen AT, Stevenson KE, Novack V, Veves A, Malhotra A. Vascular dysfunction in obstructive sleep apnea and type 2 diabetes mellitus. Obesity (Silver Spring). 2011 Jan; 19(1):17-22.
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  135. Gladysheva ES, Malhotra A, Owens RL. Influencing the decline of lung function in COPD: use of pharmacotherapy. Int J Chron Obstruct Pulmon Dis. 2010; 5:153-64.
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  136. Thomas Z, Bandali F, McCowen K, Malhotra A. Drug-induced endocrine disorders in the intensive care unit. Crit Care Med. 2010 Jun; 38(6 Suppl):S219-30.
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  137. Jordan AS, White DP, Owens RL, Eckert DJ, Rahangdale S, Yim-Yeh S, Malhotra A. The effect of increased genioglossus activity and end-expiratory lung volume on pharyngeal collapse. J Appl Physiol. 2010 Aug; 109(2):469-75.
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  138. Sharma B, Owens R, Malhotra A. Sleep in congestive heart failure. Med Clin North Am. 2010 May; 94(3):447-64.
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  139. Nemati S, Abdala O, Monasterio V, Yim-Yeh S, Malhotra A, Clifford GD. A nonparametric surrogate-based test of significance for T-wave alternans detection. IEEE Trans Biomed Eng. 2011 May; 58(5):1356-64.
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  140. Eckert DJ, Saboisky JP, Jordan AS, White DP, Malhotra A. A secondary reflex suppression phase is present in genioglossus but not tensor palatini in response to negative upper airway pressure. J Appl Physiol. 2010 Jun; 108(6):1619-24.
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  141. Kezirian EJ, White DP, Malhotra A, Ma W, McCulloch CE, Goldberg AN. Interrater reliability of drug-induced sleep endoscopy. Arch Otolaryngol Head Neck Surg. 2010 Apr; 136(4):393-7.
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  142. Campana LM, Owens RL, Clifford GD, Pittman SD, Malhotra A. Phase-rectified signal averaging as a sensitive index of autonomic changes with aging. J Appl Physiol. 2010 Jun; 108(6):1668-73.
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  143. Wilkinson V, Malhotra A, Nicholas CL, Worsnop C, Jordan AS, Butler JE, Saboisky JP, Gandevia SC, White DP, Trinder J. Discharge patterns of human genioglossus motor units during arousal from sleep. Sleep. 2010 Mar; 33(3):379-87.
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  144. Saboisky J, Eckert D, Malhotra A. Stable breathing through deeper sleeping. Thorax. 2010 Feb; 65(2):95-6.
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  145. Campana L, Eckert DJ, Patel SR, Malhotra A. Pathophysiology & genetics of obstructive sleep apnoea. Indian J Med Res. 2010 Feb; 131:176-87.
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  146. Eastwood PR, Malhotra A, Palmer LJ, Kezirian EJ, Horner RL, Ip MS, Thurnheer R, Antic NA, Hillman DR. Obstructive Sleep Apnoea: From pathogenesis to treatment: Current controversies and future directions. Respirology. 2010 May; 15(4):587-95.
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  147. Nemati S, Malhotra A, Clifford GD. Data Fusion for Improved Respiration Rate Estimation. EURASIP J Adv Signal Process. 2010; 2010:926305.
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  148. Eikermann M, Eckert DJ, Chamberlin NL, Jordan AS, Zaremba S, Smith S, Rosow C, Malhotra A. Effects of pentobarbital on upper airway patency during sleep. Eur Respir J. 2010 Sep; 36(3):569-76.
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  149. Loring SH, O'Donnell CR, Behazin N, Malhotra A, Sarge T, Ritz R, Novack V, Talmor D. Esophageal pressures in acute lung injury: do they represent artifact or useful information about transpulmonary pressure, chest wall mechanics, and lung stress? J Appl Physiol. 2010 Mar; 108(3):515-22.
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  150. Owens RL, Malhotra A, Eckert DJ, White DP, Jordan AS. The influence of end-expiratory lung volume on measurements of pharyngeal collapsibility. J Appl Physiol. 2010 Feb; 108(2):445-51.
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  151. Owens RL, Harris RS, Malhotra A. Is the way to man's heart (and lung) through the abdomen? Crit Care. 2009; 13(6):199.
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  152. Owens R, Wellman A, Malhotra A. The chicken-or-egg debate in OSA pathogenesis. Sleep. 2009 Oct; 32(10):1255-6.
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  153. Fassbender P, Geldner G, Blobner M, Hofmockel R, Rex C, Gautam S, Malhotra A, Eikermann M. Clinical predictors of duration of action of cisatracurium and rocuronium administered long-term. Am J Crit Care. 2009 Sep; 18(5):439-45.
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  154. Buckley JD, Addrizzo-Harris DJ, Clay AS, Curtis JR, Kotloff RM, Lorin SM, Murin S, Sessler CN, Rogers PL, Rosen MJ, Spevetz A, King TE, Malhotra A, Parsons PE. Multisociety task force recommendations of competencies in Pulmonary and Critical Care Medicine. Am J Respir Crit Care Med. 2009 Aug 15; 180(4):290-5.
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  155. Wiznitzer A, Mayer A, Novack V, Sheiner E, Gilutz H, Malhotra A, Novack L. Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study. Am J Obstet Gynecol. 2009 Nov; 201(5):482.e1-8.
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  156. Saboisky JP, Chamberlin NL, Malhotra A. Potential therapeutic targets in obstructive sleep apnoea. Expert Opin Ther Targets. 2009 Jul; 13(7):795-809.
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  157. Epstein LJ, Kristo D, Strollo PJ, Friedman N, Malhotra A, Patil SP, Ramar K, Rogers R, Schwab RJ, Weaver EM, Weinstein MD. Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults. J Clin Sleep Med. 2009 Jun 15; 5(3):263-76.
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  158. Eikermann M, Fassbender P, Zaremba S, Jordan AS, Rosow C, Malhotra A, Chamberlin NL. Pentobarbital dose-dependently increases respiratory genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats. Anesthesiology. 2009 Jun; 110(6):1327-34.
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  159. Yeh SY, Doupis J, Rahangdale S, Horr S, Malhotra A, Veves A. Total serum bilirubin does not affect vascular reactivity in patients with diabetes. Vasc Med. 2009 May; 14(2):129-36.
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  160. Loring SH, Garcia-Jacques M, Malhotra A. Pulmonary characteristics in COPD and mechanisms of increased work of breathing. J Appl Physiol. 2009 Jul; 107(1):309-14.
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  161. Griesdale DE, de Souza RJ, van Dam RM, Heyland DK, Cook DJ, Malhotra A, Dhaliwal R, Henderson WR, Chittock DR, Finfer S, Talmor D. Intensive insulin therapy and mortality among critically ill patients: a meta-analysis including NICE-SUGAR study data. CMAJ. 2009 Apr 14; 180(8):821-7.
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  162. Atkeson A, Yeh SY, Malhotra A, Jelic S. Endothelial function in obstructive sleep apnea. Prog Cardiovasc Dis. 2009 Mar-Apr; 51(5):351-62.
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  163. Jordan AS, White DP, Lo YL, Wellman A, Eckert DJ, Yim-Yeh S, Eikermann M, Smith SA, Stevenson KE, Malhotra A. Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea. Sleep. 2009 Mar; 32(3):361-8.
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  164. Caramez MP, Kacmarek RM, Helmy M, Miyoshi E, Malhotra A, Amato MB, Harris RS. A comparison of methods to identify open-lung PEEP. Intensive Care Med. 2009 Apr; 35(4):740-7.
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  165. Malhotra A, Loscalzo J. Sleep and cardiovascular disease: an overview. Prog Cardiovasc Dis. 2009 Jan-Feb; 51(4):279-84.
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  166. Rahangdale S, Yeh SY, Malhotra A, Veves A. Therapeutic interventions and oxidative stress in diabetes. Front Biosci. 2009; 14:192-209.
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  167. Eckert DJ, Malhotra A, Jordan AS. Mechanisms of apnea. Prog Cardiovasc Dis. 2009 Jan-Feb; 51(4):313-23.
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  168. Eckert DJ, Malhotra A, Lo YL, White DP, Jordan AS. The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep. Chest. 2009 Apr; 135(4):957-64.
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  169. Talmor D, Sarge T, Malhotra A, O'Donnell CR, Ritz R, Lisbon A, Novack V, Loring SH. Mechanical ventilation guided by esophageal pressure in acute lung injury. N Engl J Med. 2008 Nov 13; 359(20):2095-104.
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  170. Owens RL, Eckert DJ, Yeh SY, Malhotra A. Upper airway function in the pathogenesis of obstructive sleep apnea: a review of the current literature. Curr Opin Pulm Med. 2008 Nov; 14(6):519-24.
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  171. Owens RL, Hess DR, Malhotra A, Venegas JG, Harris RS. Effect of the chest wall on pressure-volume curve analysis of acute respiratory distress syndrome lungs. Crit Care Med. 2008 Nov; 36(11):2980-5.
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  172. Owens RL, Yim-Yeh S, Malhotra A. Carbon monoxide poisoning, or carbon monoxide protection? Chest. 2008 Nov; 134(5):895-6.
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  173. Malhotra A, Bertisch S, Wellman A. Complex sleep apnea: it isn't really a disease. J Clin Sleep Med. 2008 Oct 15; 4(5):406-8.
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  174. Yeh SY, Rahangdale S, Malhotra A. Metabolic syndrome, obstructive sleep apnea, and continuous positive airway pressure: a weighty issue. Chest. 2008 Oct; 134(4):675-6.
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  175. Malhotra A, Hillman D. Obesity and the lung: 3. Obesity, respiration and intensive care. Thorax. 2008 Oct; 63(10):925-31.
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  176. Rahangdale S, Campana L, Malhotra A. Not so good vibrations. Commentary on Lee et al. Heavy snoring as a cause of carotid artery atherosclerosis. SLEEP 2008;31(9):1207-1213. Sleep. 2008 Sep; 31(9):1204-5.
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  177. Eikermann M, Zaremba S, Malhotra A, Jordan AS, Rosow C, Chamberlin NL. Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing. Br J Anaesth. 2008 Sep; 101(3):344-9.
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  178. Wellman A, Malhotra A, Jordan AS, Stevenson KE, Gautam S, White DP. Effect of oxygen in obstructive sleep apnea: role of loop gain. Respir Physiol Neurobiol. 2008 Jul 31; 162(2):144-51.
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  179. Segal Y, Malhotra A, Pillar G. Upper airway length may be associated with the severity of obstructive sleep apnea syndrome. Sleep Breath. 2008 Nov; 12(4):311-6.
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  180. Elinoff J, Talmor D, Subramaniam B, Karmpaliotis D, Goldberger AL, Malhotra A. Effects of mechanical ventilation on the electrocardiogram in adults. Lung. 2008 Jul-Aug; 186(4):219-23.
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  181. Eikermann M, Malhotra A, Fassbender P, Zaremba S, Jordan AS, Gautam S, White DP, Chamberlin NL. Differential effects of isoflurane and propofol on upper airway dilator muscle activity and breathing. Anesthesiology. 2008 May; 108(5):897-906.
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  182. Wilkinson V, Malhotra A, Nicholas CL, Worsnop C, Jordan AS, Butler JE, Saboisky JP, Gandevia SC, White DP, Trinder J. Discharge patterns of human genioglossus motor units during sleep onset. Sleep. 2008 Apr; 31(4):525-33.
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  183. Heinzer R, White DP, Malhotra A, Lo YL, Dover L, Stevenson KE, Jordan AS. Effect of expiratory positive airway pressure on sleep disordered breathing. Sleep. 2008 Mar; 31(3):429-32.
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  184. Eckert DJ, Malhotra A. Pathophysiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 2008 Feb 15; 5(2):144-53.
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  185. MacDonald M, Fang J, Pittman SD, White DP, Malhotra A. The current prevalence of sleep disordered breathing in congestive heart failure patients treated with beta-blockers. J Clin Sleep Med. 2008 Feb 15; 4(1):38-42.
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  186. Jia X, Malhotra A, Saeed M, Mark RG, Talmor D. Risk factors for ARDS in patients receiving mechanical ventilation for > 48 h. Chest. 2008 Apr; 133(4):853-61.
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  187. Heinzer RC, White DP, Jordan AS, Lo YL, Dover L, Stevenson K, Malhotra A. Trazodone increases arousal threshold in obstructive sleep apnoea. Eur Respir J. 2008 Jun; 31(6):1308-12.
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  188. Caramez MP, Miyoshi E, Harris RS, Kacmarek RM, Malhotra A. Gas exchange impairment induced by open suctioning in acute respiratory distress syndrome: impact of permissive hypercapnia. Crit Care Med. 2008 Feb; 36(2):560-4.
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  189. Eikermann M, Malhotra A. Predictive value of stimulated muscle force assessment in critically ill patients. Acta Anaesthesiol Scand. 2008 Jan; 52(1):1-2.
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  190. Eckert DJ, Saboisky JP, Jordan AS, Malhotra A. Upper airway myopathy is not important in the pathophysiology of obstructive sleep apnea. J Clin Sleep Med. 2007 Oct 15; 3(6):570-3.
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  191. Talmor D, Sarge T, Legedza A, O'Donnell CR, Ritz R, Loring SH, Malhotra A. Cytokine release following recruitment maneuvers. Chest. 2007 Nov; 132(5):1434-9.
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  192. Eikermann M, Fassbender P, Malhotra A, Takahashi M, Kubo S, Jordan AS, Gautam S, White DP, Chamberlin NL. Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function. Anesthesiology. 2007 Oct; 107(4):621-9.
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  193. Ronen O, Malhotra A, Pillar G. Influence of gender and age on upper-airway length during development. Pediatrics. 2007 Oct; 120(4):e1028-34.
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  194. Malhotra A. Low-tidal-volume ventilation in the acute respiratory distress syndrome. N Engl J Med. 2007 Sep 13; 357(11):1113-20.
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  195. Stanchina ML, Ellison K, Malhotra A, Anderson M, Kirk M, Benser ME, Tosi C, Carlisle C, Millman RP, Buxton A. The impact of cardiac resynchronization therapy on obstructive sleep apnea in heart failure patients: a pilot study. Chest. 2007 Aug; 132(2):433-9.
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  196. Eikermann M, Chamberlin NL, Gerber H, Malhotra A. Muscle weakness after administration of neuromuscular blocking agents: do not immobilize the diaphragm unnecessarily. Crit Care Med. 2007 Jun; 35(6):1634-5; author reply 1635.
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  197. Eikermann M, Magder S, Malhotra A. Is brachial artery peak velocity variation ready for prime time? Chest. 2007 May; 131(5):1279-81.
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  198. Pierce R, White D, Malhotra A, Edwards JK, Kleverlaan D, Palmer L, Trinder J. Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea. Eur Respir J. 2007 Aug; 30(2):345-53.
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  199. Jordan AS, Wellman A, Heinzer RC, Lo YL, Schory K, Dover L, Gautam S, Malhotra A, White DP. Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans. Thorax. 2007 Oct; 62(10):861-7.
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  200. Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman A, Lo YL, White DP, Malhotra A. The influence of aging on pharyngeal collapsibility during sleep. Chest. 2007 Jun; 131(6):1702-9.
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  201. Karmpaliotis D, Kirtane AJ, Ruisi CP, Polonsky T, Malhotra A, Talmor D, Kosmidou I, Jarolim P, de Lemos JA, Sabatine MS, Gibson CM, Morrow D. Diagnostic and prognostic utility of brain natriuretic Peptide in subjects admitted to the ICU with hypoxic respiratory failure due to noncardiogenic and cardiogenic pulmonary edema. Chest. 2007 Apr; 131(4):964-71.
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  202. Huang Y, White DP, Malhotra A. Use of computational modeling to predict responses to upper airway surgery in obstructive sleep apnea. Laryngoscope. 2007 Apr; 117(4):648-53.
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  203. Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RA, Eikermann M, Schory K, Dover L, White DP. Influence of wakefulness on pharyngeal airway muscle activity. Thorax. 2007 Sep; 62(9):799-805.
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  204. Loring SH, Malhotra A. Inspiratory efforts during mechanical ventilation: is there risk of barotrauma? Chest. 2007 Mar; 131(3):646-8.
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  205. Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical control stability in the elderly. J Physiol. 2007 May 15; 581(Pt 1):291-8.
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  206. Yim S, Fredberg JJ, Malhotra A. Continuous positive airway pressure for asthma: not a big stretch? Eur Respir J. 2007 Feb; 29(2):226-8.
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  207. Eckert DJ, Jordan AS, Merchia P, Malhotra A. Central sleep apnea: Pathophysiology and treatment. Chest. 2007 Feb; 131(2):595-607.
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  208. Yim S, Malhotra A, Veves A. Antioxidants and CVD in diabetes: where do we stand now. Curr Diab Rep. 2007 Feb; 7(1):8-13.
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  209. Malhotra, A and Kacmarek, RM. Mechanical Ventilation. Benumof's Airway Management. 2007; 1079-1122.
  210. Goodwin A, Bajwa E, Malhotra A. . Non-invasive determination of cardiac output. Intensive Care Medicine. 2007; in press.
  211. Wellman, DA, Malhotra, A, Jordan, AS, Schory, K, Gautam, S, White, Dp. Chemical control stability in the elderly. J. Physiol. (London). 2007; 581:291-298.
  212. Kacmarek R, Villar J, Malhotra A. . Modes of Mechanical Ventilation. 2007; in press.
  213. Shochat, T, Pillar, G, Malhotra, A, . Aging and Sleep. Int J Sleep Disorders. 2007; 1:92-101.
  214. Malhotra A, Kacmarek R. . Mechanical Ventilation. Anesthetic Principles in Critical Care. 2007; in press.
  215. Benson, A, Bajwa E, Malhotra A. . Pulmonary Disease. Pocket Medicine: The MGH Handbook of Internal Medicine. 2007; in press.
  216. Eikermann, M, Magder, S, Malhotra, A, . Estimating Preload using Non-invasive means. Chest. 2007; in press.
  217. Stanchina M, Malhotra A, White DP. . An evidenced-based review of the diagnosis and treatment of respiratory disorders of sleep. Crapo and King. 2007; in press.
  218. Malhotra A, Fogel R, White DP. . Disorders of excessive sleepiness. Neurological Therapeutics: Principles and Practice. 2007; in press.
  219. Eikermann, M, Magder, S, Malhotra, A. Is brachial artery peak velocity variation a viable method for prediction of volume responsiveness in critically ill patients?. Chest. 2007; in press.
  220. Nguyen A, Yim S, Malhotra A. . Theories of OSA Pathogenesis. In Obstructive Sleep Apnea. 2007; in press.
  221. Chamberlin NL, Eikermann M, Fassbender P, White DP, Malhotra A. Genioglossus premotoneurons and the negative pressure reflex in rats. J Physiol. 2007 Mar 1; 579(Pt 2):515-26.
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  222. Pittman SD, Pillar G, Berry RB, Malhotra A, MacDonald MM, White DP. Follow-up assessment of CPAP efficacy in patients with obstructive sleep apnea using an ambulatory device based on peripheral arterial tonometry. Sleep Breath. 2006 Sep; 10(3):123-31.
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  223. Patel SR, Malhotra A, White DP, Gottlieb DJ, Hu FB. Association between reduced sleep and weight gain in women. Am J Epidemiol. 2006 Nov 15; 164(10):947-54.
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  224. Cho MH, Malhotra A, Donahue DM, Wain JC, Harris RS, Karmpaliotis D, Patel SR. Mechanical ventilation and air leaks after lung biopsy for acute respiratory distress syndrome. Ann Thorac Surg. 2006 Jul; 82(1):261-6.
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  225. Patel SR, Malhotra A, Gottlieb DJ, White DP, Hu FB. Correlates of long sleep duration. Sleep. 2006 Jul; 29(7):881-9.
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  226. Caramez MP, Schettino G, Suchodolski K, Nishida T, Harris RS, Malhotra A, Kacmarek RM. The impact of endotracheal suctioning on gas exchange and hemodynamics during lung-protective ventilation in acute respiratory distress syndrome. Respir Care. 2006 May; 51(5):497-502.
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  227. Talmor D, Sarge T, O'Donnell CR, Ritz R, Malhotra A, Lisbon A, Loring SH. Esophageal and transpulmonary pressures in acute respiratory failure. Crit Care Med. 2006 May; 34(5):1389-94.
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  228. Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep. Sleep. 2006 Apr; 29(4):470-7.
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  229. Heinzer RC, Stanchina ML, Malhotra A, Jordan AS, Patel SR, Lo YL, Wellman A, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea. Thorax. 2006 May; 61(5):435-9.
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  230. Malhotra A. Intensive insulin in intensive care. N Engl J Med. 2006 Feb 2; 354(5):516-8.
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  231. Yinon D, Lowenstein L, Suraya S, Beloosesky R, Zmora O, Malhotra A, Pillar G. Pre-eclampsia is associated with sleep-disordered breathing and endothelial dysfunction. Eur Respir J. 2006 Feb; 27(2):328-33.
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  232. Hammer L, Dessertaine G, Timset JF, Aberegg SK, Tamler R, Leroith D, Roth J, Van den Berghe G, Wilmer A, Boullon R, Malhotra A. . Intensive Insulin in the Medical Intensive Care Unit,. New Engl J Med. 2006; 354:2069-2071.
  233. Malhotra A, Huang Y, Fogel R, Lazic S, Pillar G, Jakab M, Kikinis R, White DP. Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse. Am J Med. 2006 Jan; 119(1):72.e9-14.
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  234. Kacmarek RM, Malhotra A. . Equipment required for home mechanical ventilation. Principles and Practice of Mechanical Ventilation (Ed MJ Tobin). 2006; in press.
  235. Malhotra A, Patel S. Lung biopsy in ARDS: is it worth the risk? Crit Care. 2006; 10(4):160.
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  236. Heinzer, R., Jordan, AS, Malhotra, A, . Sleep Apnea Syndrome. Wiley Encyclopedia of Biomedical Engineering,. 2006.
  237. Malhotra A, Jordan AS. Did fat boy Joe need hormone replacement? Sleep. 2006 Jan; 29(1):16-8.
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  238. Yim S, Jordan AS, Malhotra A. . Obstructive sleep apnea, clinical presentation, diagnosis and treatment. Sleep Apnea – Current diagnosis and treatment. 2006; 35:118-136.
  239. Nguyen TN, Badjatia N, Malhotra A, Gibbons FK, Qureshi MM, Greenberg SA. Factors predicting extubation success in patients with Guillain-Barré syndrome. Neurocrit Care. 2006; 5(3):230-4.
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  240. Pillar G, Harder L, Malhotra A. . Trauma and post-traumatic stress disorder. Encyclopedia of Sleep Medicine. 2006; 857-866.
  241. Huang Y, White DP, Malhotra A. The impact of anatomic manipulations on pharyngeal collapse: results from a computational model of the normal human upper airway. Chest. 2005 Sep; 128(3):1324-30.
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  242. Jordan A, Malhotra A. The pharyngeal lumen: both length and size matter. J Clin Sleep Med. 2005 Jul 15; 1(3):264-5.
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  243. Bajwa EK, Ayas NT, Schulzer M, Mak E, Ryu JH, Malhotra A. Interferon-gamma1b therapy in idiopathic pulmonary fibrosis: a metaanalysis. Chest. 2005 Jul; 128(1):203-6.
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  244. Caramez MP, Borges JB, Tucci MR, Okamoto VN, Carvalho CR, Kacmarek RM, Malhotra A, Velasco IT, Amato MB. Paradoxical responses to positive end-expiratory pressure in patients with airway obstruction during controlled ventilation. Crit Care Med. 2005 Jul; 33(7):1519-28.
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  245. Jordan AS, Wellman A, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP. Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea. J Appl Physiol. 2005 Nov; 99(5):2020-7.
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  246. Ting L, Malhotra A. Disorders of sleep: an overview. Prim Care. 2005 Jun; 32(2):305-18, v.
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  247. Aloia MS, Stanchina M, Arnedt JT, Malhotra A, Millman RP. Treatment adherence and outcomes in flexible vs standard continuous positive airway pressure therapy. Chest. 2005 Jun; 127(6):2085-93.
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  248. Huang Y, Malhotra A, White DP. Computational simulation of human upper airway collapse using a pressure-/state-dependent model of genioglossal muscle contraction under laminar flow conditions. J Appl Physiol. 2005 Sep; 99(3):1138-48.
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  249. Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan AS, Schory K, White DP. Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea. Am J Respir Crit Care Med. 2005 Jul 1; 172(1):114-7.
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  250. Malhotra A, Jordan A. Surface tension and sleep apnea: a sticky business. Sleep. 2005 Apr; 28(4):392-3.
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  251. Kacmarek RM, Malhotra A. High-frequency oscillatory ventilation: what large-animal studies have taught us! Crit Care Med. 2005 Mar; 33(3 Suppl):S148-54.
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  252. Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ. The effect of sleep onset on upper airway muscle activity in patients with sleep apnoea versus controls. J Physiol. 2005 Apr 15; 564(Pt 2):549-62.
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  253. Malhotra A. . Pathophysiology of cardiovascular disease. 2005.
  254. Sharma S, Malhotra A. . Comment on risk factors of relative adrenocortical deficiency in intensive care patients needing mechanical ventilation. 2005.
  255. Nguyen A, Malhotra A. . Comment on short-term and long-term effects of nasal intermittent positive pressure ventilation in patients with obesity-hypoventilation syndrome. 2005.
  256. Malhotra A, Berry R, White DP. . Central sleep apnea. In Clinical Sleep Disorders. Clinical Sleep Disorders. 2005; 331-346.
  257. Jordan A, Malhotra A. . Pharyngeal lumen: both length and size matter. JCSM. 2005; 1:262-263.
  258. Bajwa EK, Malhotra A, Thompson BT. Methods of monitoring shock. Semin Respir Crit Care Med. 2004 Dec; 25(6):629-44.
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  259. Pittman SD, MacDonald MM, Fogel RB, Malhotra A, Todros K, Levy B, Geva AB, White DP. Assessment of automated scoring of polysomnographic recordings in a population with suspected sleep-disordered breathing. Sleep. 2004 Nov 1; 27(7):1394-403.
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  260. Malhotra A, Trinder J, Fogel R, Stanchina M, Patel SR, Schory K, Kleverlaan D, White DP. Postural effects on pharyngeal protective reflex mechanisms. Sleep. 2004 Sep 15; 27(6):1105-12.
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  261. Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea. Am J Respir Crit Care Med. 2004 Dec 1; 170(11):1225-32.
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  262. Pittman SD, Ayas NT, MacDonald MM, Malhotra A, Fogel RB, White DP. Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation. Sleep. 2004 Aug 1; 27(5):923-33.
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  263. Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang CK, Catcheside PG, Fogel RB, Malhotra A, White DP. The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans. J Physiol. 2004 Aug 1; 558(Pt 3):993-1004.
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  264. Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis. Sleep. 2004 Mar 15; 27(2):249-53.
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  265. Fogel RB, Malhotra A, White DP. Sleep. 2: pathophysiology of obstructive sleep apnoea/hypopnoea syndrome. Thorax. 2004 Feb; 59(2):159-63.
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  266. Oddo M, Liaudet L, Patel SR, Wain J, Malhotra A. . Open-lung biopsy for ARDS Patients. Chest. 2004; 126:1003-1004.
  267. Bajwa, E, Mouded, M, Systrom, DM, and Malhotra, A. Pulmonary Disease. Pocket Medicine: The MGH Handbook in Internal Medicine. 2004.
  268. Patel SR, Karmpaliotis D, Ayas NT, Mark EJ, Wain J, Thompson BT, Malhotra A. The role of open-lung biopsy in ARDS. Chest. 2004 Jan; 125(1):197-202.
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  269. Inoue K, Takano H, Yanagisawa R, Sakurai M, Yoshikawa T, Patel S, Wain J, Malhotra A. . Surgical stress in ARDS open-lung biopsy. Chest. 2004; 126:1383-1384.
  270. Stanchina ML, Malhotra A, Fogel RB, Trinder J, Edwards JK, Schory K, White DP. The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep. Sleep. 2003 Nov 1; 26(7):851-6.
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  271. Carden K, Malhotra A. The debate about gender differences in obstructive sleep apnea. Sleep Med. 2003 Nov; 4(6):485-7.
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  272. Fogel RB, White DP, Pierce RJ, Malhotra A, Edwards JK, Dunai J, Kleverlaan D, Trinder J. Control of upper airway muscle activity in younger versus older men during sleep onset. J Physiol. 2003 Dec 1; 553(Pt 2):533-44.
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  273. Fogel RB, Trinder J, Malhotra A, Stanchina M, Edwards JK, Schory KE, White DP. Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state. J Physiol. 2003 Aug 1; 550(Pt 3):899-910.
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  274. Malhotra A, Muse VV, Mark EJ. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-2003. An 82-year-old man with dyspnea and pulmonary abnormalities. N Engl J Med. 2003 Apr 17; 348(16):1574-85.
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  275. Patel SR, White DP, Malhotra A, Stanchina ML, Ayas NT. Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis. Arch Intern Med. 2003 Mar 10; 163(5):565-71.
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  276. Pillar G, Schuscheim G, Weiss R, Malhotra A, McCowen KC, Shlitner A, Peled N, Shehadeh N. Interactions between hypoglycemia and sleep architecture in children with type 1 diabetes mellitus. J Pediatr. 2003 Feb; 142(2):163-8.
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  277. Ayas NT, White DP, Manson JE, Stampfer MJ, Speizer FE, Malhotra A, Hu FB. A prospective study of sleep duration and coronary heart disease in women. Arch Intern Med. 2003 Jan 27; 163(2):205-9.
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  278. Berry RB, White DP, Roper J, Pillar G, Fogel RB, Stanchina M, Malhotra A. Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects. J Appl Physiol. 2003 May; 94(5):1875-82.
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  279. Huang Y, Malhotra A, White DP. . A computational model of upper airway collapsibility. IEEE conference. 2003.
  280. McCowen, KC and Malhotra, A. The correlation between OSA and low gonadotropin secretion in men. Sleep Medicine. 2003; 4:83-84.
  281. Snow A, Gozal E, Malhotra A, Tiosano D, Perlman R, Vega C, Shahar E, Gozal D, Hochberg Z, Pillar G. Severe hypersomnolence after pituitary/hypothalamic surgery in adolescents: clinical characteristics and potential mechanisms. Pediatrics. 2002 Dec; 110(6):e74.
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  282. Malhotra A, Huang Y, Fogel RB, Pillar G, Edwards JK, Kikinis R, Loring SH, White DP. The male predisposition to pharyngeal collapse: importance of airway length. Am J Respir Crit Care Med. 2002 Nov 15; 166(10):1388-95.
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  283. Wellman A, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. Respiratory system loop gain in normal men and women measured with proportional-assist ventilation. J Appl Physiol. 2003 Jan; 94(1):205-12.
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  284. Patel SR, Harris RS, Malhotra A. Pulmonary dead space and survival. N Engl J Med. 2002 Sep 12; 347(11):850-2; author reply 850-2.
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  285. Karmpaliotis D, Kosmidou I, Ingenito EP, Hong K, Malhotra A, Sunday ME, Haley KJ. Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2002 Sep; 283(3):L585-95.
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  286. Wellman A, Malhotra A, White DP. Atrial pacing in sleep apnea syndrome. N Engl J Med. 2002 Aug 8; 347(6):445-6; author reply 445-6.
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  287. Malhotra A, White DP. Obstructive sleep apnoea. Lancet. 2002 Jul 20; 360(9328):237-45.
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  288. Fisher D, Pillar G, Malhotra A, Peled N, Lavie P. Long-term follow-up of untreated patients with sleep apnoea syndrome. Respir Med. 2002 May; 96(5):337-43.
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  289. Stanchina ML, Malhotra A, Fogel RB, Ayas N, Edwards JK, Schory K, White DP. Genioglossus muscle responsiveness to chemical and mechanical stimuli during non-rapid eye movement sleep. Am J Respir Crit Care Med. 2002 Apr 1; 165(7):945-9.
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  290. Malhotra A, Ayas N, Kacmarek R. Prone positioning of patients in acute respiratory failure. N Engl J Med. 2002 Jan 24; 346(4):295-7.
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  291. Lavie, P, Pillar, G, Malhotra, A. Sleep disorders: diagnosis, management and treatment. 2002; 1-189.
  292. Malhotra, A and White, DP. The pathogenesis of obstructive sleep apnoea. Breathing Disorders During Sleep. 2002; 44-64.
  293. Malhotra A, Huang Y, White DP. . Upper airway mechanics: influence of gender. Proc. Second Joint EMBS/BMES Conference. 2002; 1544-1545.
  294. Murthy A, Malhotra A. . Invited Commentaries for Journal Club of the Assembly on Critical Care of the American Thoracic Society. 2002.
  295. Malhotra A, Pillar G, Fogel RB, Edwards JK, Ayas N, Akahoshi T, Hess D, White DP. Pharyngeal pressure and flow effects on genioglossus activation in normal subjects. Am J Respir Crit Care Med. 2002 Jan 1; 165(1):71-7.
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  296. Malhotra, A, Schwartz, D. Lung Cancer. Respiratory Care: Principles and Practice. 2002; 1151-1167.
  297. Malhotra AK, Fabian TC, Croce MA, Weiman DS, Gavant ML, Pate JW. Minimal aortic injury: a lesion associated with advancing diagnostic techniques. J Trauma. 2001 Dec; 51(6):1042-8.
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  298. Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP. Genioglossal activation in patients with obstructive sleep apnea versus control subjects. Mechanisms of muscle control. Am J Respir Crit Care Med. 2001 Dec 1; 164(11):2025-30.
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  299. Pillar G, Fogel RB, Malhotra A, Beauregard J, Edwards JK, Shea SA, White DP. Genioglossal inspiratory activation: central respiratory vs mechanoreceptive influences. Respir Physiol. 2001 Aug; 127(1):23-38.
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  300. Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards J, White DP. Upper-airway collapsibility: measurements and sleep effects. Chest. 2001 Jul; 120(1):156-61.
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  301. Hilton MF, Chappell MJ, Bartlett WA, Malhotra A, Beattie JM, Cayton RM. The sleep apnoea/hypopnoea syndrome depresses waking vagal tone independent of sympathetic activation. Eur Respir J. 2001 Jun; 17(6):1258-66.
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  302. Malhotra A, Schwartz DR, Ayas N, Stanchina M, White DP. Treatment of oxygen-induced hypercapnia. Lancet. 2001 Mar 17; 357(9259):884-5.
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  303. Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2001 Mar; 86(3):1175-80.
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  304. McCowen KC, Malhotra A, Bistrian BR. Stress-induced hyperglycemia. Crit Care Clin. 2001 Jan; 17(1):107-24.
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  305. Stanchina M, Patel S, Malhotra A. . The Answer Page. Web-based learning tool. Wrote 20 sections on various respiratory and critical care physiology topics. 2001.
  306. Pillar G, Malhotra A, Fogel R, Beauregard J, Schnall R, White DP. Airway mechanics and ventilation in response to resistive loading during sleep: influence of gender. Am J Respir Crit Care Med. 2000 Nov; 162(5):1627-32.
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  307. Malhotra A, Ayas NT, Epstein LJ. The art and science of continuous positive airway pressure therapy in obstructive sleep apnea. Curr Opin Pulm Med. 2000 Nov; 6(6):490-5.
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  308. Pillar G, Malhotra A, Fogel RB, Beauregard J, Slamowitz DI, Shea SA, White DP. Upper airway muscle responsiveness to rising PCO(2) during NREM sleep. J Appl Physiol. 2000 Oct; 89(4):1275-82.
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  309. Malhotra A, Pillar G, Fogel RB, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure. Am J Respir Crit Care Med. 2000 Sep; 162(3 Pt 1):1058-62.
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  310. Schwartz DR, Malhotra A, Fink MP. Microcirculatory weak units--an alternative explanation. Crit Care Med. 2000 Aug; 28(8):3127-9.
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  311. Malhotra AK, Fabian TC, Katsis SB, Gavant ML, Croce MA. Blunt bowel and mesenteric injuries: the role of screening computed tomography. J Trauma. 2000 Jun; 48(6):991-8; discussion 998-1000.
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  312. Malhotra A, Fogel RB, Edwards JK, Shea SA, White DP. Local mechanisms drive genioglossus activation in obstructive sleep apnea. Am J Respir Crit Care Med. 2000 May; 161(5):1746-9.
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  313. Pillar G, Malhotra A, Lavie P. Post-traumatic stress disorder and sleep-what a nightmare! Sleep Med Rev. 2000 Apr; 4(2):183-200.
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  314. Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP. Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA. J Appl Physiol. 2000 Apr; 88(4):1346-54.
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  315. Pittman SD, Tal N, Pillar G, Malhotra A, Hilton M, Fogel R, Ayas N, White DP. . Automated detection of obstructive sleep-disordered breathing events using peripheral arterial tonometry and oximetry. Computers in Cardiology. 2000; 27:485-488.
  316. Schwartz D, Malhotra A, Kacmarek R. Prone Positioning in Acute Respiratory Distress Syndrome. 2000.
  317. Sabatine, M, Malhotra, A, Systrom, DM. Pulmonary Disease. Pocket Medicine: The MGH Handbook of Internal Medicine. 2000; 2-1-21.
  318. Pittman SD, Hill PD, Malhotra A, Ayas N, Fogel R, White DP. . Stabilizing Cheyne Stokes respiration associated with congestive heart failure using computer-assisted positive airway pressure. Computers in Cardiology. 2000; 201-204.
  319. Schwartz, DR, Malhotra, A, Fink, MP. Cytopathic Hypoxia in Septic Shock. Advances in Structural Biology. 2000; 65-82.
  320. Ayas NT, Malhotra A, Epstein LJ. Alternative therapies for sleep apnea. Drugs Today (Barc). 1999 Nov; 35(11):811-21.
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  321. Schwartz DR, Maroo A, Malhotra A, Kesselman H. Negative pressure pulmonary hemorrhage. Chest. 1999 Apr; 115(4):1194-7.
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  322. Schwartz, D, Malhotra, A, Fink, MP. Cytopathic hypoxia in sepsis: an overview. Sepsis. 1999; 279-289.
  323. Schwartz D, Malhotra A, Weinberger S. . Pulmonary Embolus in Pregnancy. 1999.
  324. Malhotra A, Fogel R, Pillar G, Winkelman J. . Non-pulmonary Aspects of Sleep Medicine for Pulmonary and Critical Care Update (PCCU). 1999.
  325. Malhotra A, Schwartz D Schwartzstein, R. . Oxygen Toxicity. 1998.
  326. Malhotra, A and Kradin, R. The pulmonary immune response to asbestos. Asbestos and Cancer (Eds. Peters & Peters). 1997; 1-32.
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