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Barbara Emily Bierer, M.D.

TitleProfessor of Medicine (Pediatrics)
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Administration, PB-4
75 Francis St
Boston MA 02115
Phone617/732-8990
Fax617/264-6339

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Weingart SN, Price J, Duncombe D, Connor M, Conley K, Conlin GJ, Sullivan AM, Powell M, Ponte PR, Bierer BE. Enhancing safety reporting in adult ambulatory oncology with a clinician champion: a practice innovation. J Nurs Care Qual. 2009 Jul-Sep; 24(3):203-10.
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  2. Weingart SN, Price J, Duncombe D, Connor M, Sommer K, Conley KA, Bierer BE, Ponte PR. Patient-reported safety and quality of care in outpatient oncology. Jt Comm J Qual Patient Saf. 2007 Feb; 33(2):83-94.
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  3. Morley SC, Sung J, Sun GP, Martelli MP, Bunnell SC, Bierer BE. Gelsolin overexpression alters actin dynamics and tyrosine phosphorylation of lipid raft-associated proteins in Jurkat T cells. Mol Immunol. 2007 Mar; 44(9):2469-80.
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  4. Foley JE, Jung U, Miera A, Borenstein T, Mariotti J, Eckhaus M, Bierer BE, Fowler DH. Ex vivo rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanism. J Immunol. 2005 Nov 1; 175(9):5732-43.
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  5. Cristillo AD, Bierer BE. Regulation of CXCR4 expression in human T lymphocytes by calcium and calcineurin. Mol Immunol. 2003 Dec; 40(8):539-53.
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  6. Salazar-Fontana LI, Barr V, Samelson LE, Bierer BE. CD28 engagement promotes actin polymerization through the activation of the small Rho GTPase Cdc42 in human T cells. J Immunol. 2003 Sep 1; 171(5):2225-32.
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  7. Cristillo AD, Nie L, Macri MJ, Bierer BE. Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes. J Biol Chem. 2003 Sep 5; 278(36):34587-97.
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  8. Celeste Morley S, Sun GP, Bierer BE. Inhibition of actin polymerization enhances commitment to and execution of apoptosis induced by withdrawal of trophic support. J Cell Biochem. 2003 Apr 1; 88(5):1066-76.
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  9. Cristillo AD, Macri MJ, Bierer BE. Differential chemokine expression profiles in human peripheral blood T lymphocytes: dependence on T-cell coreceptor and calcineurin signaling. Blood. 2003 Jan 1; 101(1):216-25.
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  10. Cristillo AD, Xiao X, Campbell-Malone R, Dimitrov DS, Bierer BE. Differences between CEM and human peripheral blood T lymphocytes in cAMP-dependent HIV viral fusion and CXCR4 expression. Exp Mol Pathol. 2002 Aug; 73(1):9-18.
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  11. Cristillo AD, Highbarger HC, Dewar RL, Dimitrov DS, Golding H, Bierer BE. Up-regulation of HIV coreceptor CXCR4 expression in human T lymphocytes is mediated in part by a cAMP-responsive element. FASEB J. 2002 Mar; 16(3):354-64.
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  12. Li TK, Baksh S, Cristillo AD, Bierer BE. Calcium- and FK506-independent interaction between the immunophilin FKBP51 and calcineurin. J Cell Biochem. 2002; 84(3):460-71.
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  13. Cristillo AD, Bierer BE. Identification of novel targets of immunosuppressive agents by cDNA-based microarray analysis. J Biol Chem. 2002 Feb 8; 277(6):4465-76.
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  14. Martelli MP, Boomer J, Bu M, Bierer BE. T cell regulation of p62(dok) (Dok1) association with Crk-L. J Biol Chem. 2001 Dec 7; 276(49):45654-61.
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  15. Winston DJ, Antin JH, Wolff SN, Bierer BE, Small T, Miller KB, Linker C, Kaizer H, Lazarus HM, Petersen FB, Cowan MJ, Ho WG, Wingard JR, Schiller GJ, Territo MC, Jiao J, Petrarca MA, Tonetta SA. A multicenter, randomized, double-blind comparison of different doses of intravenous immunoglobulin for prevention of graft-versus-host disease and infection after allogeneic bone marrow transplantation. Bone Marrow Transplant. 2001 Jul; 28(2):187-96.
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  16. Lin H, Martelli MP, Bierer BE. The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell activation. Int Immunol. 2001 Jan; 13(1):13-22.
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  17. Salazar-Fontana LI, Bierer BE. T-lymphocyte coactivator molecules. Curr Opin Hematol. 2001 Jan; 8(1):5-11.
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  18. Morley SC, Bierer BE. The actin cytoskeleton, membrane lipid microdomains, and T cell signal transduction. Adv Immunol. 2001; 77:1-43.
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  19. Stillwell R, Bierer BE. T cell signal transduction and the role of CD7 in costimulation. Immunol Res. 2001; 24(1):31-52.
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  20. Martelli MP, Lin H, Zhang W, Samelson LE, Bierer BE. Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation. Blood. 2000 Sep 15; 96(6):2181-90.
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  21. Ouyang Y, Virasch N, Hao P, Aubrey MT, Mukerjee N, Bierer BE, Freed BM. Suppression of human IL-1beta, IL-2, IFN-gamma, and TNF-alpha production by cigarette smoke extracts. J Allergy Clin Immunol. 2000 Aug; 106(2):280-7.
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  22. Posey SC, Martelli MP, Azuma T, Kwiatkowski DJ, Bierer BE. Failure of gelsolin overexpression to regulate lymphocyte apoptosis. Blood. 2000 Jun 1; 95(11):3483-8.
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  23. Tirnauer JS, Bierer BE. EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability. J Cell Biol. 2000 May 15; 149(4):761-6.
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  24. Tirnauer JS, O'Toole E, Berrueta L, Bierer BE, Pellman D. Yeast Bim1p promotes the G1-specific dynamics of microtubules. J Cell Biol. 1999 May 31; 145(5):993-1007.
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  25. Berrueta L, Tirnauer JS, Schuyler SC, Pellman D, Bierer BE. The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. Curr Biol. 1999 Apr 22; 9(8):425-8.
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  26. Posey SC, Bierer BE. Actin stabilization by jasplakinolide enhances apoptosis induced by cytokine deprivation. J Biol Chem. 1999 Feb 12; 274(7):4259-65.
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  27. Slavik JM, Hutchcroft JE, Bierer BE. CD80 and CD86 are not equivalent in their ability to induce the tyrosine phosphorylation of CD28. J Biol Chem. 1999 Jan 29; 274(5):3116-24.
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  28. Slavik JM, Hutchcroft JE, Bierer BE. CD28/CTLA-4 and CD80/CD86 families: signaling and function. Immunol Res. 1999; 19(1):1-24.
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  29. Hutchcroft JE, Slavik JM, Lin H, Watanabe T, Bierer BE. Uncoupling activation-dependent HS1 phosphorylation from nuclear factor of activated T cells transcriptional activation in Jurkat T cells: differential signaling through CD3 and the costimulatory receptors CD2 and CD28. J Immunol. 1998 Nov 1; 161(9):4506-12.
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  30. Berrueta L, Kraeft SK, Tirnauer JS, Schuyler SC, Chen LB, Hill DE, Pellman D, Bierer BE. The adenomatous polyposis coli-binding protein EB1 is associated with cytoplasmic and spindle microtubules. Proc Natl Acad Sci U S A. 1998 Sep 1; 95(18):10596-601.
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  31. Kivens WJ, Hunt SW, Mobley JL, Zell T, Dell CL, Bierer BE, Shimizu Y. Identification of a proline-rich sequence in the CD2 cytoplasmic domain critical for regulation of integrin-mediated adhesion and activation of phosphoinositide 3-kinase. Mol Cell Biol. 1998 Sep; 18(9):5291-307.
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  32. Lin H, Hutchcroft JE, Andoniou CE, Kamoun M, Band H, Bierer BE. Association of p59(fyn) with the T lymphocyte costimulatory receptor CD2. Binding of the Fyn Src homology (SH) 3 domain is regulated by the Fyn SH2 domain. J Biol Chem. 1998 Jul 31; 273(31):19914-21.
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  33. Dunussi-Joannopoulos K, Dranoff G, Weinstein HJ, Ferrara JL, Bierer BE, Croop JM. Gene immunotherapy in murine acute myeloid leukemia: granulocyte-macrophage colony-stimulating factor tumor cell vaccines elicit more potent antitumor immunity compared with B7 family and other cytokine vaccines. Blood. 1998 Jan 1; 91(1):222-30.
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  34. Ballen KK, Gilliland DG, Guinan EC, Hsieh CC, Parsons SK, Rimm IJ, Ferrara JL, Bierer BE, Weinstein HJ, Antin JH. Bone marrow transplantation for therapy-related myelodysplasia: comparison with primary myelodysplasia. Bone Marrow Transplant. 1997 Nov; 20(9):737-43.
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  35. Trede NS, Warwick AB, Rosoff PM, Rohrer R, Bierer BE, Guinan E. Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation. Bone Marrow Transplant. 1997 Aug; 20(3):257-60.
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  36. Wheeler C, Eickhoff C, Elias A, Ibrahim J, Ayash L, McCauley M, Mauch P, Schwartz G, Eder JP, Mazanet R, Ferrara J, Rimm IJ, Guinan E, Bierer B, Gilliland G, Churchill WH, Ault K, Parsons S, Antman K, Schnipper L, Tepler I, Gaynes L, Frei E, Kadin M, Antin J. High-dose cyclophosphamide, carmustine, and etoposide with autologous transplantation in Hodgkin's disease: a prognostic model for treatment outcomes. Biol Blood Marrow Transplant. 1997 Jun; 3(2):98-106.
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  37. Lee SJ, Wegner SA, McGarigle CJ, Bierer BE, Antin JH. Treatment of chronic graft-versus-host disease with clofazimine. Blood. 1997 Apr 1; 89(7):2298-302.
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  38. Lehmann LE, Guinan EC, Halpern SL, Donovan MJ, Bierer BE, Parsons SK. Isolated testicular relapse in an adolescent 5 years following allogeneic bone marrow transplantation for acute myelogenous leukemia. Bone Marrow Transplant. 1997 Apr; 19(8):849-51.
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  39. Sagoo JK, Fruman DA, Wesselborg S, Walsh CT, Bierer BE. Competitive inhibition of calcineurin phosphatase activity by its autoinhibitory domain. Biochem J. 1996 Dec 15; 320 ( Pt 3):879-84.
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  40. Hutchcroft JE, Tsai B, Bierer BE. Differential phosphorylation of the T lymphocyte costimulatory receptor CD28. Activation-dependent changes and regulation by protein kinase C. J Biol Chem. 1996 Jun 7; 271(23):13362-70.
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  41. Hutchcroft JE, Bierer BE. Signaling through CD28/CTLA-4 family receptors: puzzling participation of phosphatidylinositol-3 kinase. J Immunol. 1996 Jun 1; 156(11):4071-4.
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  42. Fay JW, Wingard JR, Antin JH, Collins RH, Piñeiro LA, Blazar BR, Saral R, Bierer BE, Przepiorka D, Fitzsimmons WE, Maher RM, Weisdorf DJ. FK506 (Tacrolimus) monotherapy for prevention of graft-versus-host disease after histocompatible sibling allogenic bone marrow transplantation. Blood. 1996 Apr 15; 87(8):3514-9.
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  43. Wesselborg S, Fruman DA, Sagoo JK, Bierer BE, Burakoff SJ. Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp). J Biol Chem. 1996 Jan 19; 271(3):1274-7.
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  44. Yeh WC, Li TK, Bierer BE, McKnight SL. Identification and characterization of an immunophilin expressed during the clonal expansion phase of adipocyte differentiation. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):11081-5.
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  45. Yeh WC, Bierer BE, McKnight SL. Rapamycin inhibits clonal expansion and adipogenic differentiation of 3T3-L1 cells. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):11086-90.
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  46. Hutchcroft JE, Franklin DP, Tsai B, Harrison-Findik D, Varticovski L, Bierer BE. Phorbol ester treatment inhibits phosphatidylinositol 3-kinase activation by, and association with, CD28, a T-lymphocyte surface receptor. Proc Natl Acad Sci U S A. 1995 Sep 12; 92(19):8808-12.
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  47. Fruman DA, Pai SY, Burakoff SJ, Bierer BE. Characterization of a mutant calcineurin A alpha gene expressed by EL4 lymphoma cells. Mol Cell Biol. 1995 Jul; 15(7):3857-63.
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  48. Bierer BE. Mechanisms of action of immunosuppressive agents: cyclosporin A, FK506, and rapamycin. Proc Assoc Am Physicians. 1995 Apr; 107(1):28-40.
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  49. Fruman DA, Bierer BE, Benes JE, Burakoff SJ, Austen KF, Katz HR. The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells. J Immunol. 1995 Feb 15; 154(4):1846-51.
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  50. Fruman DA, Wood MA, Gjertson CK, Katz HR, Burakoff SJ, Bierer BE. FK506 binding protein 12 mediates sensitivity to both FK506 and rapamycin in murine mast cells. Eur J Immunol. 1995 Feb; 25(2):563-71.
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  51. Liu SJ, Hahn WC, Bierer BE, Golan DE. Intracellular mediators regulate CD2 lateral diffusion and cytoplasmic Ca2+ mobilization upon CD2-mediated T cell activation. Biophys J. 1995 Feb; 68(2):459-70.
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  52. Pai SY, Fruman DA, Leong T, Neuberg D, Rosano TG, McGarigle C, Antin JH, Bierer BE. Inhibition of calcineurin phosphatase activity in adult bone marrow transplant patients treated with cyclosporine A. Blood. 1994 Dec 1; 84(11):3974-9.
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  53. Holländer GA, Fruman DA, Bierer BE, Burakoff SJ. Disruption of T cell development and repertoire selection by calcineurin inhibition in vivo. Transplantation. 1994 Nov 15; 58(9):1037-43.
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  54. Calvo V, Wood M, Gjertson C, Vik T, Bierer BE. Activation of 70-kDa S6 kinase, induced by the cytokines interleukin-3 and erythropoietin and inhibited by rapamycin, is not an absolute requirement for cell proliferation. Eur J Immunol. 1994 Nov; 24(11):2664-71.
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  55. Pai SY, Calvo V, Wood M, Bierer BE. Cross-linking CD28 leads to activation of 70-kDa S6 kinase. Eur J Immunol. 1994 Oct; 24(10):2364-8.
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  56. Menu E, Tsai BC, Bothwell AL, Sims PJ, Bierer BE. CD59 costimulation of T cell activation. CD58 dependence and requirement for glycosylation. J Immunol. 1994 Sep 15; 153(6):2444-56.
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  57. Holländer GA, Bierer BE, Burakoff SJ. Molecular and biological actions of cyclosporin A and FK506 on T cell development and function. Transfus Sci. 1994 Sep; 15(3):207-20.
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  58. Antin JH, Weinstein HJ, Guinan EC, McCarthy P, Bierer BE, Gilliland DG, Parsons SK, Ballen KK, Rimm IJ, Falzarano G, et al. Recombinant human interleukin-1 receptor antagonist in the treatment of steroid-resistant graft-versus-host disease. Blood. 1994 Aug 15; 84(4):1342-8.
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  59. Collins TL, Kassner PD, Bierer BE, Burakoff SJ. Adhesion receptors in lymphocyte activation. Curr Opin Immunol. 1994 Jun; 6(3):385-93.
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  60. Hutchcroft JE, Bierer BE. Activation-dependent phosphorylation of the T-lymphocyte surface receptor CD28 and associated proteins. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3260-4.
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  61. Fruman DA, Burakoff SJ, Bierer BE. Immunophilins in protein folding and immunosuppression. FASEB J. 1994 Apr 1; 8(6):391-400.
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  62. Bierer BE. Biology of cyclosporin A and FK506. Prog Clin Biol Res. 1994; 390:203-23.
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  63. Bierer BE. Cyclosporin A, FK506, and rapamycin: binding to immunophilins and biological action. Chem Immunol. 1994; 59:128-55.
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  64. Hendrickson BA, Zhang W, Craig RJ, Jin YJ, Bierer BE, Burakoff S, DiLella AG. Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1. Gene. 1993 Dec 8; 134(2):271-5.
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  65. Hahn WC, Bierer BE. Separable portions of the CD2 cytoplasmic domain involved in signaling and ligand avidity regulation. J Exp Med. 1993 Nov 1; 178(5):1831-6.
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  66. Bierer BE, Holländer G, Fruman D, Burakoff SJ. Cyclosporin A and FK506: molecular mechanisms of immunosuppression and probes for transplantation biology. Curr Opin Immunol. 1993 Oct; 5(5):763-73.
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  67. Nigam SK, Jin YJ, Jin MJ, Bush KT, Bierer BE, Burakoff SJ. Localization of the FK506-binding protein, FKBP 13, to the lumen of the endoplasmic reticulum. Biochem J. 1993 Sep 1; 294 ( Pt 2):511-5.
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  68. Bierer BE, Hahn WC. T cell adhesion, avidity regulation and signaling: a molecular analysis of CD2. Semin Immunol. 1993 Aug; 5(4):249-61.
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  69. Wheeler C, Strawderman M, Ayash L, Churchill WH, Bierer BE, Elias A, Gilliland DG, Antman K, Guinan EC, Eder JP, et al. Prognostic factors for treatment outcome in autotransplantation of intermediate-grade and high-grade non-Hodgkin's lymphoma with cyclophosphamide, carmustine, and etoposide. J Clin Oncol. 1993 Jun; 11(6):1085-91.
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  70. Hahn WC, Menzin E, Saito T, Germain RN, Bierer BE. The complete sequences of plasmids pFNeo and pMH-Neo: convenient expression vectors for high-level expression of eukaryotic genes in hematopoietic cell lines. Gene. 1993 May 30; 127(2):267-8.
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  71. Dutz JP, Fruman DA, Burakoff SJ, Bierer BE. A role for calcineurin in degranulation of murine cytotoxic T lymphocytes. J Immunol. 1993 Apr 1; 150(7):2591-8.
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  72. Hahn WC, Burakoff SJ, Bierer BE. Signal transduction pathways involved in T cell receptor-induced regulation of CD2 avidity for CD58. J Immunol. 1993 Apr 1; 150(7):2607-19.
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  73. Offringa R, Bierer BE. Association of CD2 with tubulin. Evidence for a role of the cytoskeleton in T cell activation. J Biol Chem. 1993 Mar 5; 268(7):4979-88.
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  74. Goust JM, Bierer B. Cell-mediated immunity. Immunol Ser. 1993; 58:187-212.
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  75. Collins TL, Hahn WC, Bierer BE, Burakoff SJ. CD4, CD8 and CD2 in T cell adhesion and signaling. Curr Top Microbiol Immunol. 1993; 184:223-33.
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  76. Fruman DA, Mather PE, Burakoff SJ, Bierer BE. Correlation of calcineurin phosphatase activity and programmed cell death in murine T cell hybridomas. Eur J Immunol. 1992 Oct; 22(10):2513-7.
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  77. Kaye RE, Fruman DA, Bierer BE, Albers MW, Zydowsky LD, Ho SI, Jin YJ, Castells MC, Schreiber SL, Walsh CT, et al. Effects of cyclosporin A and FK506 on Fc epsilon receptor type I-initiated increases in cytokine mRNA in mouse bone marrow-derived progenitor mast cells: resistance to FK506 is associated with a deficiency in FK506-binding protein FKBP12. Proc Natl Acad Sci U S A. 1992 Sep 15; 89(18):8542-6.
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  78. Arceci RJ, Stieglitz K, Bierer BE. Immunosuppressants FK506 and rapamycin function as reversal agents of the multidrug resistance phenotype. Blood. 1992 Sep 15; 80(6):1528-36.
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  79. Calvo V, Crews CM, Vik TA, Bierer BE. Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7571-5.
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  80. Price DJ, Grove JR, Calvo V, Avruch J, Bierer BE. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science. 1992 Aug 14; 257(5072):973-7.
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  81. Hahn WC, Rosenstein Y, Calvo V, Burakoff SJ, Bierer BE. A distinct cytoplasmic domain of CD2 regulates ligand avidity and T-cell responsiveness to antigen. Proc Natl Acad Sci U S A. 1992 Aug 1; 89(15):7179-83.
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  82. Hahn WC, Menu E, Bothwell AL, Sims PJ, Bierer BE. Overlapping but nonidentical binding sites on CD2 for CD58 and a second ligand CD59. Science. 1992 Jun 26; 256(5065):1805-7.
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  83. Jin YJ, Burakoff SJ, Bierer BE. Molecular cloning of a 25-kDa high affinity rapamycin binding protein, FKBP25. J Biol Chem. 1992 Jun 5; 267(16):10942-5.
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  84. Höllsberg P, Wucherpfennig KW, Ausubel LJ, Calvo V, Bierer BE, Hafler DA. Characterization of HTLV-I in vivo infected T cell clones. IL-2-independent growth of nontransformed T cells. J Immunol. 1992 May 15; 148(10):3256-63.
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  85. Fruman DA, Klee CB, Bierer BE, Burakoff SJ. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK 506 and cyclosporin A. Proc Natl Acad Sci U S A. 1992 May 1; 89(9):3686-90.
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  86. Calvo V, Bierer BE, Vik TA. T cell receptor activation of a ribosomal S6 kinase activity. Eur J Immunol. 1992 Feb; 22(2):457-62.
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  87. Bierer BE, Jin YJ, Fruman DA, Calvo V, Burakoff SJ. FK 506 and rapamycin: molecular probes of T-lymphocyte activation. Transplant Proc. 1991 Dec; 23(6):2850-5.
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  88. Rosenstein Y, Park JK, Hahn WC, Rosen FS, Bierer BE, Burakoff SJ. CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1. Nature. 1991 Nov 21; 354(6350):233-5.
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  89. Antin JH, Bierer BE, Smith BR, Ferrara J, Guinan EC, Sieff C, Golan DE, Macklis RM, Tarbell NJ, Lynch E, et al. Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies. Blood. 1991 Oct 15; 78(8):2139-49.
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  90. Jin YJ, Albers MW, Lane WS, Bierer BE, Schreiber SL, Burakoff SJ. Molecular cloning of a membrane-associated human FK506- and rapamycin-binding protein, FKBP-13. Proc Natl Acad Sci U S A. 1991 Aug 1; 88(15):6677-81.
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  91. Hahn WC, Rosenstein Y, Burakoff SJ, Bierer BE. Interaction of CD2 with its ligand lymphocyte function-associated antigen-3 induces adenosine 3',5'-cyclic monophosphate production in T lymphocytes. J Immunol. 1991 Jul 1; 147(1):14-21.
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  92. Park JK, Rosenstein YJ, Remold-O'Donnell E, Bierer BE, Rosen FS, Burakoff SJ. Enhancement of T-cell activation by the CD43 molecule whose expression is defective in Wiskott-Aldrich syndrome. Nature. 1991 Apr 25; 350(6320):706-9.
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  93. Bierer BE, Schreiber SL, Burakoff SJ. The effect of the immunosuppressant FK-506 on alternate pathways of T cell activation. Eur J Immunol. 1991 Feb; 21(2):439-45.
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  94. Bierer BE, Burakoff SJ. T cell receptors: adhesion and signaling. Adv Cancer Res. 1991; 56:49-76.
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  95. Bierer BE, Mattila PS, Standaert RF, Herzenberg LA, Burakoff SJ, Crabtree G, Schreiber SL. Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin. Proc Natl Acad Sci U S A. 1990 Dec; 87(23):9231-5.
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  96. Bierer BE, Nathan DG. The effect of desferrithiocin, an oral iron chelator, on T-cell function. Blood. 1990 Nov 15; 76(10):2052-9.
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  97. Bierer BE, Somers PK, Wandless TJ, Burakoff SJ, Schreiber SL. Probing immunosuppressant action with a nonnatural immunophilin ligand. Science. 1990 Oct 26; 250(4980):556-9.
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  98. Bierer BE, Schreiber SL, Burakoff SJ. Mechanisms of immunosuppression by FK506. Preservation of T cell transmembrane signal transduction. Transplantation. 1990 Jun; 49(6):1168-70.
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  99. Wolff HL, Burakoff SJ, Bierer BE. Functional CD2 mutants unable to bind to, or be stimulated by, LFA-3. J Immunol. 1990 Feb 15; 144(4):1215-20.
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  100. Bierer BE, Bogart RE, Burakoff SJ. Partial deletions of the cytoplasmic domain of CD2 result in a partial defect in signal transduction. J Immunol. 1990 Feb 1; 144(3):785-9.
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  101. Antin JH, Bierer BE, Smith BR, Guinan EC, Provost MM, Ferrara J, Macklis RM, Tarbell NJ, Blythman H, Bouloux C, et al. Depletion of bone marrow T-lymphocytes with an anti-CD5 monoclonal immunotoxin (ST-1 immunotoxin): effective prophylaxis for graft-versus-host disease. Prog Clin Biol Res. 1990; 333:207-15.
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  102. Bierer BE, Burakoff SJ. T-lymphocyte activation: the biology and function of CD2 and CD4. Immunol Rev. 1989 Oct; 111:267-94.
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  103. Bierer BE, Golan DE, Brown CS, Herrmann SH, Burakoff SJ. A monoclonal antibody to LFA-3, the CD2 ligand, specifically immobilizes major histocompatibility complex proteins. Eur J Immunol. 1989 Apr; 19(4):661-5.
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  104. Bierer BE, Burakoff SJ, Smith BR. A large proportion of T lymphocytes lack CD5 expression after bone marrow transplantation. Blood. 1989 Apr; 73(5):1359-66.
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  105. Niemeyer CM, Sieff CA, Mathey-Prevot B, Wimperis JZ, Bierer BE, Clark SC, Nathan DG. Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. Blood. 1989 Mar; 73(4):945-51.
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  106. Bierer BE, Sleckman BP, Ratnofsky SE, Burakoff SJ. The biologic roles of CD2, CD4, and CD8 in T-cell activation. Annu Rev Immunol. 1989; 7:579-99.
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  107. Bierer BE, Emerson SG, Antin J, Maziarz R, Rappeport JM, Smith BR, Burakoff SJ. Regulation of cytotoxic T lymphocyte-mediated graft rejection following bone marrow transplantation. Transplantation. 1988 Dec; 46(6):835-9.
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  108. Nishimura Y, Bierer BE, Burakoff SJ. Expression of CD5 regulates responsiveness to IL-1. J Immunol. 1988 Nov 15; 141(10):3438-44.
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  109. Virella G, Rugeles MT, Hyman B, La Via M, Goust JM, Frankis M, Bierer BE. The interaction of CD2 with its LFA-3 ligand expressed by autologous erythrocytes results in enhancement of B cell responses. Cell Immunol. 1988 Oct 15; 116(2):308-19.
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  110. Bierer BE, Peterson A, Gorga JC, Herrmann SH, Burakoff SJ. Synergistic T cell activation via the physiological ligands for CD2 and the T cell receptor. J Exp Med. 1988 Sep 1; 168(3):1145-56.
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  111. Bierer BE, Burakoff SJ. T cell adhesion molecules. FASEB J. 1988 Jul; 2(10):2584-90.
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  112. Bierer BE, Barbosa J, Herrmann S, Burakoff SJ. Interaction of CD2 with its ligand, LFA-3, in human T cell proliferation. J Immunol. 1988 May 15; 140(10):3358-63.
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  113. Nishimura Y, Bierer BE, Jones WK, Jones NH, Strominger JL, Burakoff SJ. Expression and function of a CD5 cDNA in human and murine T cells. Eur J Immunol. 1988 May; 18(5):747-53.
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  114. Bierer BE, Nishimura Y, Burakoff SJ, Smith BR. Phenotypic and functional characterization of human cytolytic T cells lacking expression of CD5. J Clin Invest. 1988 May; 81(5):1390-7.
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  115. Bierer BE, Peterson A, Barbosa J, Seed B, Burakoff SJ. Expression of the T-cell surface molecule CD2 and an epitope-loss CD2 mutant to define the role of lymphocyte function-associated antigen 3 (LFA-3) in T-cell activation. Proc Natl Acad Sci U S A. 1988 Feb; 85(4):1194-8.
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  116. Goldman SJ, Bierer BE, Burakoff SJ. Analysis of CD4 and CD2 receptor function. Princess Takamatsu Symp. 1988; 19:149-60.
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  117. Bierer BE, Greenstein JL, Sleckman B, Ratnofsky S, Peterson A, Seed B, Burakoff SJ. Functional analysis of CD2, CD4, and CD8 in T-cell activation. Ann N Y Acad Sci. 1988; 532:199-206.
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  118. Bierer BE, Herrmann SH, Brown CS, Burakoff SJ, Golan DE. Lateral mobility of class I histocompatibility antigens in B lymphoblastoid cell membranes: modulation by cross-linking and effect of cell density. J Cell Biol. 1987 Sep; 105(3):1147-52.
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  119. Krangel MS, Bierer BE, Devlin P, Clabby M, Strominger JL, McLean J, Brenner MB. T3 glycoprotein is functional although structurally distinct on human T-cell receptor gamma T lymphocytes. Proc Natl Acad Sci U S A. 1987 Jun; 84(11):3817-21.
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  120. Mentzer SJ, Remold-O'Donnell E, Crimmins MA, Bierer BE, Rosen FS, Burakoff SJ. Sialophorin, a surface sialoglycoprotein defective in the Wiskott-Aldrich syndrome, is involved in human T lymphocyte proliferation. J Exp Med. 1987 May 1; 165(5):1383-92.
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  121. Mentzer SJ, Bierer BE, Anderson DC, Springer TA, Burakoff SJ. Abnormal cytolytic activity of lymphocyte function-associated antigen-1-deficient human cytolytic T lymphocyte clones. J Clin Invest. 1986 Nov; 78(5):1387-91.
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  122. Bringhurst FR, Bierer BE, Godeau F, Neyhard N, Varner V, Segre GV. Humoral hypercalcemia of malignancy. Release of a prostaglandin-stimulating bone-resorbing factor in vitro by human transitional-cell carcinoma cells. J Clin Invest. 1986 Feb; 77(2):456-64.
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  123. Bierer BE, Mentzer SJ, Greenstein JL, Burakoff SJ. The role of functional cell surface antigens in T cell activation. Year Immunol. 1986; 2:39-59.
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  124. Herrmann HC, Kaplan LM, Bierer BE. Q-T prolongation and torsades de pointes ventricular tachycardia produced by the tetracyclic antidepressant agent maprotiline. Am J Cardiol. 1983 Mar 1; 51(5):904-6.
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  125. Rosa RM, Bierer BE, Bunn HF, Epstein FH. The treatment of sickle cell anemia with induced hyponatremia. Blood Cells. 1982; 8(2):329-35.
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  126. Rosa RM, Bierer BE, Thomas R, Stoff JS, Kruskall M, Robinson S, Bunn HF, Epstein FH. A study of induced hyponatremia in the prevention and treatment of sickle-cell crisis. N Engl J Med. 1980 Nov 13; 303(20):1138-43.
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  127. Rosa RM, Bierer B, Thomas R, Stoff JS, Kruskall M, Robinson S, Bunn HF, Epstein FH. Prevention and treatment of sickle cell crisis by induced hyponatremia. Trans Assoc Am Physicians. 1980; 93:164-74.
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