Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Tracey Lynn Petryshen, Ph.D.

TitleAssistant Professor of Psychiatry
InstitutionMassachusetts General Hospital
DepartmentPsychiatry
AddressMassachusetts General Hospital
Center for Human Genetic Research
185 Cambridge St
Boston MA 02114
Phone617/726-4960

 Mentoring 
 current student opportunities
Available: 01/06/14, Expires: 08/28/15

The ankyrin 3 gene (ANK3) has been identified by large-scale patient genome-wide association studies as one of the strongest genetic risk factors for bipolar disorder. We and others have obtained evidence that the ankyrin G protein encoded by ANK3 localizes to the synapse of neurons in the brain where it may scaffold cell membrane proteins such as ion channels and neurotransmitter receptors. This project will investigate whether ankyrin G forms complexes with known synaptic membrane components (e.g., NMDA receptors). The student will utilize techniques including Western blot analysis and co-immunoprecipitation to identify synaptic proteins bound to ankyrin G. The results may provide insight into the role of ANK3 in synaptic function in the brain and risk of bipolar disorder.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Del Re EC, Bergen SE, Mesholam-Gately RI, Niznikiewicz MA, Goldstein JM, Woo TU, Shenton ME, Seidman LJ, McCarley RW, Petryshen TL. Analysis of schizophrenia-related genes and electrophysiological measures reveals ZNF804A association with amplitude of P300b elicited by novel sounds. Transl Psychiatry. 2014; 4:e346.
    View in: PubMed
  2. Goldstein JM, Cherkerzian S, Tsuang MT, Petryshen TL. Sex differences in the genetic risk for schizophrenia: History of the evidence for sex-specific and sex-dependent effects. Am J Med Genet B Neuropsychiatr Genet. 2013 Oct; 162(7):698-710.
    View in: PubMed
  3. Schroeder FA, Lewis MC, Fass DM, Wagner FF, Zhang YL, Hennig KM, Gale J, Zhao WN, Reis S, Barker DD, Berry-Scott E, Kim SW, Clore EL, Hooker JM, Holson EB, Haggarty SJ, Petryshen TL. A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests. PLoS One. 2013; 8(8):e71323.
    View in: PubMed
  4. Logue MW, Solovieff N, Leussis MP, Wolf EJ, Melista E, Baldwin C, Koenen KC, Petryshen TL, Miller MW. The ankyrin-3 gene is associated with posttraumatic stress disorder and externalizing comorbidity. Psychoneuroendocrinology. 2013 Oct; 38(10):2249-57.
    View in: PubMed
  5. Leussis MP, Berry-Scott EM, Saito M, Jhuang H, de Haan G, Alkan O, Luce CJ, Madison JM, Sklar P, Serre T, Root DE, Petryshen TL. The ANK3 Bipolar Disorder Gene Regulates Psychiatric-Related Behaviors That Are Modulated by Lithium and Stress. Biol Psychiatry. 2013 Apr 1; 73(7):683-90.
    View in: PubMed
  6. Pasternak O, Westin CF, Bouix S, Seidman LJ, Goldstein JM, Woo TU, Petryshen TL, Mesholam-Gately RI, McCarley RW, Kikinis R, Shenton ME, Kubicki M. Excessive extracellular volume reveals a neurodegenerative pattern in schizophrenia onset. J Neurosci. 2012 Nov 28; 32(48):17365-72.
    View in: PubMed
  7. Leussis MP, Madison JM, Petryshen TL. Ankyrin 3: genetic association with bipolar disorder and relevance to disease pathophysiology. Biol Mood Anxiety Disord. 2012; 2(1):18.
    View in: PubMed
  8. Bergen SE, Petryshen TL. Genome-wide association studies of schizophrenia: does bigger lead to better results? Curr Opin Psychiatry. 2012 Mar; 25(2):76-82.
    View in: PubMed
  9. Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, Haggarty SJ. AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacology. 2011 Jun; 36(7):1397-411.
    View in: PubMed
  10. Goldstein JM, Cherkerzian S, Seidman LJ, Petryshen TL, Fitzmaurice G, Tsuang MT, Buka SL. Sex-specific rates of transmission of psychosis in the New England high-risk family study. Schizophr Res. 2011 May; 128(1-3):150-5.
    View in: PubMed
  11. Leussis MP, Frayne ML, Saito M, Berry EM, Aldinger KA, Rockwell GN, Hammer RP, Baskin-Hill AE, Singer JB, Nadeau JH, Sklar P, Petryshen TL. Genomic survey of prepulse inhibition in mouse chromosome substitution strains. Genes Brain Behav. 2009 Nov; 8(8):806-16.
    View in: PubMed
  12. Petryshen TL, Pauls DL. The genetics of reading disability. Curr Psychiatry Rep. 2009 Apr; 11(2):149-55.
    View in: PubMed
  13. Mao Y, Ge X, Frank CL, Madison JM, Koehler AN, Doud MK, Tassa C, Berry EM, Soda T, Singh KK, Biechele T, Petryshen TL, Moon RT, Haggarty SJ, Tsai LH. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling. Cell. 2009 Mar 20; 136(6):1017-31.
    View in: PubMed
  14. Petryshen TL, Sabeti PC, Aldinger KA, Fry B, Fan JB, Schaffner SF, Waggoner SG, Tahl AR, Sklar P. Population genetic study of the brain-derived neurotrophic factor (BDNF) gene. Mol Psychiatry. 2010 Aug; 15(8):810-5.
    View in: PubMed
  15. Perlis RH, Purcell S, Fagerness J, Kirby A, Petryshen TL, Fan J, Sklar P. Family-based association study of lithium-related and other candidate genes in bipolar disorder. Arch Gen Psychiatry. 2008 Jan; 65(1):53-61.
    View in: PubMed
  16. Scolnick EM, Petryshen T, Sklar P. Schizophrenia: do the genetics and neurobiology of neuregulin provide a pathogenesis model? Harv Rev Psychiatry. 2006 Mar-Apr; 14(2):64-77.
    View in: PubMed
  17. Petryshen TL, Middleton FA, Tahl AR, Rockwell GN, Purcell S, Aldinger KA, Kirby A, Morley CP, McGann L, Gentile KL, Waggoner SG, Medeiros HM, Carvalho C, Macedo A, Albus M, Maier W, Trixler M, Eichhammer P, Schwab SG, Wildenauer DB, Azevedo MH, Pato MT, Pato CN, Daly MJ, Sklar P. Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia. Mol Psychiatry. 2005 Dec; 10(12):1074-88, 1057.
    View in: PubMed
  18. Petryshen TL, Kirby A, Hammer RP, Purcell S, O'Leary SB, Singer JB, Hill AE, Nadeau JH, Daly MJ, Sklar P. Two quantitative trait loci for prepulse inhibition of startle identified on mouse chromosome 16 using chromosome substitution strains. Genetics. 2005 Dec; 171(4):1895-904.
    View in: PubMed
  19. Petryshen TL, Middleton FA, Kirby A, Aldinger KA, Purcell S, Tahl AR, Morley CP, McGann L, Gentile KL, Rockwell GN, Medeiros HM, Carvalho C, Macedo A, Dourado A, Valente J, Ferreira CP, Patterson NJ, Azevedo MH, Daly MJ, Pato CN, Pato MT, Sklar P. Support for involvement of neuregulin 1 in schizophrenia pathophysiology. Mol Psychiatry. 2005 Apr; 10(4):366-74, 328.
    View in: PubMed
  20. Tzenova J, Kaplan BJ, Petryshen TL, Field LL. Confirmation of a dyslexia susceptibility locus on chromosome 1p34-p36 in a set of 100 Canadian families. Am J Med Genet B Neuropsychiatr Genet. 2004 May 15; 127B(1):117-24.
    View in: PubMed
  21. Pato CN, Pato MT, Kirby A, Petryshen TL, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, Soares MJ, Ferreira CP, Lei M, Verner A, Hudson TJ, Morley CP, Kennedy JL, Azevedo MH, Daly MJ, Sklar P. Genome-wide scan in Portuguese Island families implicates multiple loci in bipolar disorder: fine mapping adds support on chromosomes 6 and 11. Am J Med Genet B Neuropsychiatr Genet. 2004 May 15; 127B(1):30-4.
    View in: PubMed
  22. Middleton FA, Pato MT, Gentile KL, Morley CP, Zhao X, Eisener AF, Brown A, Petryshen TL, Kirby AN, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, Soares MJ, Ferreira CP, Lei M, Azevedo MH, Kennedy JL, Daly MJ, Sklar P, Pato CN. Genomewide linkage analysis of bipolar disorder by use of a high-density single-nucleotide-polymorphism (SNP) genotyping assay: a comparison with microsatellite marker assays and finding of significant linkage to chromosome 6q22. Am J Hum Genet. 2004 May; 74(5):886-97.
    View in: PubMed
  23. Freedman ML, Reich D, Penney KL, McDonald GJ, Mignault AA, Patterson N, Gabriel SB, Topol EJ, Smoller JW, Pato CN, Pato MT, Petryshen TL, Kolonel LN, Lander ES, Sklar P, Henderson B, Hirschhorn JN, Altshuler D. Assessing the impact of population stratification on genetic association studies. Nat Genet. 2004 Apr; 36(4):388-93.
    View in: PubMed
  24. Hsiung GY, Kaplan BJ, Petryshen TL, Lu S, Field LL. A dyslexia susceptibility locus (DYX7) linked to dopamine D4 receptor (DRD4) region on chromosome 11p15.5. Am J Med Genet B Neuropsychiatr Genet. 2004 Feb 15; 125B(1):112-9.
    View in: PubMed
  25. Sklar P, Pato MT, Kirby A, Petryshen TL, Medeiros H, Carvalho C, Macedo A, Dourado A, Coelho I, Valente J, Soares MJ, Ferreira CP, Lei M, Verner A, Hudson TJ, Morley CP, Kennedy JL, Azevedo MH, Lander E, Daly MJ, Pato CN. Genome-wide scan in Portuguese Island families identifies 5q31-5q35 as a susceptibility locus for schizophrenia and psychosis. Mol Psychiatry. 2004 Feb; 9(2):213-8.
    View in: PubMed
  26. Nelson B, Parsons AB, Evangelista M, Schaefer K, Kennedy K, Ritchie S, Petryshen TL, Boone C. Fus1p interacts with components of the Hog1p mitogen-activated protein kinase and Cdc42p morphogenesis signaling pathways to control cell fusion during yeast mating. Genetics. 2004 Jan; 166(1):67-77.
    View in: PubMed
  27. Petryshen TL, Kaplan BJ, Hughes ML, Tzenova J, Field LL. Supportive evidence for the DYX3 dyslexia susceptibility gene in Canadian families. J Med Genet. 2002 Feb; 39(2):125-6.
    View in: PubMed
  28. Petryshen TL, Kaplan BJ, Fu Liu M, de French NS, Tobias R, Hughes ML, Field LL. Evidence for a susceptibility locus on chromosome 6q influencing phonological coding dyslexia. Am J Med Genet. 2001 Aug 8; 105(6):507-17.
    View in: PubMed
  29. Petryshen TL, Kaplan BJ, Liu MF, Field LL. Absence of significant linkage between phonological coding dyslexia and chromosome 6p23-21.3, as determined by use of quantitative-trait methods: confirmation of qualitative analyses. Am J Hum Genet. 2000 Feb; 66(2):708-14.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Petryshen's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_