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Keywords
Last Name
Institution

John Henry Hartwig, PH.D.

TitleProfessor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham & Women's Hospital
Karp 6
One Blackfan Circle
Boston MA 02215
Phone617/278-0323
Fax617/355-9016

 Mentoring 
 completed student projects
What Is the Role of Filamin 1 in Myeloid Cell Function?
Part Time, 03/01/99 - 06/18/99
The Relationship between Mutacin Production and Early Childhood Caries
Full Time, 06/21/04 - 08/01/04
Role of Cofilin in the Cytoskeletal Rearrangements of Activated Platelets
Full Time/Year Long, 07/01/98 - 06/30/99
The Relationship Between Filamin B, an Actin-binding Protein Isoform, and the Glycoprotein Ib-Ix complex in the Human Platelet
Part Time/Continuation, 09/01/00 - 06/01/01
The Relationship Between Filamin B, an Actin-binding Protein Isoform, and the Glycoprotein Ib-Ix Complex in the Human Platelet
Summer/Continuation, 06/18/00 - 08/31/00
role of teh Actin Filament Depolymerizing Factor Cofilin in the Cytoskeletal Rearrangements of Activated Platelets
Full Time/Year Long, 01/03/00 - 06/30/00
Outside-In Integration Signaling Accelerates Platelet Action Filament Turnover
Part Time/Continuation, 09/01/00 - 12/31/00
What is the Role of Filamin 1 in Myeloid Cell Function?
Part Time/Continuation, 09/01/99 - 01/01/00
The Relationship Between Filamin B, an Actin-binding Protein isoform, and the Glycoprotein Ib-Ix complex in the Human Platelet
Part Time, 01/03/00 - 06/15/00
What is the Role of Filamin 1 in Myeloid Cell Function?
Summer, 06/21/99 - 08/31/99
Impact of Limited English and Physician Language Concordance on Health Care Delivery and Patient Satisfaction
Full Time, 07/05/04 - 08/27/04
Role of the Actin Filament Depolymerizing Factor Cofilin in the Cytoskeletal Rearrangements of Activated Platelets
Full Time, 09/01/99 - 11/30/99
Regulatory T cells in Merkel Cell Carcinoma
Summer, 06/19/06 - 08/25/06

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang Y, Zhao L, Suzuki A, Lian L, Min SH, Wang Z, Litvinov RI, Stalker TJ, Yago T, Klopocki AG, Schmidtke DW, Yin H, Choi JK, McEver RP, Weisel JW, Hartwig JH, Abrams CS. Platelets lacking PIP5KI? have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion. Blood. 2013 Apr 4; 121(14):2743-52.
    View in: PubMed
  2. Bishai EA, Sidhu GS, Li W, Dhillon J, Bohil AB, Cheney RE, Hartwig JH, Southwick FS. Myosin-X facilitates Shigella-induced membrane protrusions and cell-to-cell spread. Cell Microbiol. 2013 Mar; 15(3):353-67.
    View in: PubMed
  3. Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS. Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell. 2012 Nov 13; 22(5):615-30.
    View in: PubMed
  4. Suphamungmee W, Nakamura F, Hartwig JH, Lehman W. Electron Microscopy and 3D Reconstruction Reveals Filamin Ig Domain Binding to F-Actin. J Mol Biol. 2012 Dec 14; 424(5):248-56.
    View in: PubMed
  5. Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano JE, Hartwig JH, Walter U. Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis. Exp Hematol. 2013 Jan; 41(1):91-101.e4.
    View in: PubMed
  6. Thon JN, Macleod H, Begonja AJ, Zhu J, Lee KC, Mogilner A, Hartwig JH, Italiano JE. Microtubule and cortical forces determine platelet size during vascular platelet production. Nat Commun. 2012; 3:852.
    View in: PubMed
  7. Wandall HH, Rumjantseva V, Sørensen AL, Patel-Hett S, Josefsson EC, Bennett EP, Italiano JE, Clausen H, Hartwig JH, Hoffmeister KM. The origin and function of platelet glycosyltransferases. Blood. 2012 Jul 19; 120(3):626-35.
    View in: PubMed
  8. Thomas GM, Carbo C, Curtis BR, Martinod K, Mazo IB, Schatzberg D, Cifuni SM, Fuchs TA, von Andrian UH, Hartwig JH, Aster RH, Wagner DD. Extracellular DNA traps are associated with the pathogenesis of TRALI in humans and mice. Blood. 2012 Jun 28; 119(26):6335-43.
    View in: PubMed
  9. Rullo J, Becker H, Hyduk SJ, Wong JC, Digby G, Arora PD, Cano AP, Hartwig J, McCulloch CA, Cybulsky MI. Actin polymerization stabilizes a4ß1 integrin anchors that mediate monocyte adhesion. J Cell Biol. 2012 Apr 2; 197(1):115-29.
    View in: PubMed
  10. Recher M, Burns SO, de la Fuente MA, Volpi S, Dahlberg C, Walter JE, Moffitt K, Mathew D, Honke N, Lang PA, Patrizi L, Falet H, Keszei M, Mizui M, Csizmadia E, Candotti F, Nadeau K, Bouma G, Delmonte OM, Frugoni F, Fomin AB, Buchbinder D, Lundequist EM, Massaad MJ, Tsokos GC, Hartwig J, Manis J, Terhorst C, Geha RS, Snapper S, Lang KS, Malley R, Westerberg L, Thrasher AJ, Notarangelo LD. B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice. Blood. 2012 Mar 22; 119(12):2819-28.
    View in: PubMed
  11. Jansen AJ, Josefsson EC, Rumjantseva V, Liu QP, Falet H, Bergmeier W, Cifuni SM, Sackstein R, von Andrian UH, Wagner DD, Hartwig JH, Hoffmeister KM. Desialylation accelerates platelet clearance after refrigeration and initiates GPIba metalloproteinase-mediated cleavage in mice. Blood. 2012 Feb 2; 119(5):1263-73.
    View in: PubMed
  12. Ehrlicher AJ, Nakamura F, Hartwig JH, Weitz DA, Stossel TP. Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature. 2011 Oct 13; 478(7368):260-3.
    View in: PubMed
  13. Hammarfjord O, Falet H, Gurniak C, Hartwig JH, Wallin RP. Gelsolin-independent podosome formation in dendritic cells. PLoS One. 2011; 6(7):e21615.
    View in: PubMed
  14. Gay O, Gilquin B, Nakamura F, Jenkins ZA, McCartney R, Krakow D, Deshiere A, Assard N, Hartwig JH, Robertson SP, Baudier J. RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11464-9.
    View in: PubMed
  15. Jurak Begonja A, Hoffmeister KM, Hartwig JH, Falet H. FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly. Blood. 2011 Aug 25; 118(8):2285-95.
    View in: PubMed
  16. Patel-Hett S, Wang H, Begonja AJ, Thon JN, Alden EC, Wandersee NJ, An X, Mohandas N, Hartwig JH, Italiano JE. The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. Blood. 2011 Aug 11; 118(6):1641-52.
    View in: PubMed
  17. Nakamura F, Stossel TP, Hartwig JH. The filamins: organizers of cell structure and function. Cell Adh Migr. 2011 Mar-Apr; 5(2):160-9.
    View in: PubMed
  18. Ehrlicher A, Hartwig JH. Cell mechanics: Contracting to stiffness. Nat Mater. 2011 Jan; 10(1):12-3.
    View in: PubMed
  19. Thon JN, Montalvo A, Patel-Hett S, Devine MT, Richardson JL, Ehrlicher A, Larson MK, Hoffmeister K, Hartwig JH, Italiano JE. Cytoskeletal mechanics of proplatelet maturation and platelet release. J Cell Biol. 2010 Nov 15; 191(4):861-74.
    View in: PubMed
  20. Gu C, Yaddanapudi S, Weins A, Osborn T, Reiser J, Pollak M, Hartwig J, Sever S. Direct dynamin-actin interactions regulate the actin cytoskeleton. EMBO J. 2010 Nov 3; 29(21):3593-606.
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  21. Fuchs TA, Brill A, Duerschmied D, Schatzberg D, Monestier M, Myers DD, Wrobleski SK, Wakefield TW, Hartwig JH, Wagner DD. Extracellular DNA traps promote thrombosis. Proc Natl Acad Sci U S A. 2010 Sep 7; 107(36):15880-5.
    View in: PubMed
  22. Falet H, Pollitt AY, Begonja AJ, Weber SE, Duerschmied D, Wagner DD, Watson SP, Hartwig JH. A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function. J Exp Med. 2010 Aug 30; 207(9):1967-79.
    View in: PubMed
  23. Moyer JD, Nowak RB, Kim NE, Larkin SK, Peters LL, Hartwig J, Kuypers FA, Fowler VM. Tropomodulin 1-null mice have a mild spherocytic elliptocytosis with appearance of tropomodulin 3 in red blood cells and disruption of the membrane skeleton. Blood. 2010 Oct 7; 116(14):2590-9.
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  24. Bender M, Eckly A, Hartwig JH, Elvers M, Pleines I, Gupta S, Krohne G, Jeanclos E, Gohla A, Gurniak C, Gachet C, Witke W, Nieswandt B. ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing. Blood. 2010 Sep 9; 116(10):1767-75.
    View in: PubMed
  25. Playford MP, Nurminen E, Pentikäinen OT, Milgram SL, Hartwig JH, Stossel TP, Nakamura F. Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A. J Biol Chem. 2010 May 28; 285(22):17156-65.
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  26. Hughes CE, Pollitt AY, Mori J, Eble JA, Tomlinson MG, Hartwig JH, O'Callaghan CA, Fütterer K, Watson SP. CLEC-2 activates Syk through dimerization. Blood. 2010 Apr 8; 115(14):2947-55.
    View in: PubMed
  27. Zhou AX, Hartwig JH, Akyürek LM. Filamins in cell signaling, transcription and organ development. Trends Cell Biol. 2010 Feb; 20(2):113-23.
    View in: PubMed
  28. Rumjantseva V, Grewal PK, Wandall HH, Josefsson EC, Sørensen AL, Larson G, Marth JD, Hartwig JH, Hoffmeister KM. Dual roles for hepatic lectin receptors in the clearance of chilled platelets. Nat Med. 2009 Nov; 15(11):1273-80.
    View in: PubMed
  29. Falet H, Marchetti MP, Hoffmeister KM, Massaad MJ, Geha RS, Hartwig JH. Platelet-associated IgAs and impaired GPVI responses in platelets lacking WIP. Blood. 2009 Nov 19; 114(21):4729-37.
    View in: PubMed
  30. Koenderink GH, Dogic Z, Nakamura F, Bendix PM, MacKintosh FC, Hartwig JH, Stossel TP, Weitz DA. An active biopolymer network controlled by molecular motors. Proc Natl Acad Sci U S A. 2009 Sep 8; 106(36):15192-7.
    View in: PubMed
  31. Sørensen AL, Rumjantseva V, Nayeb-Hashemi S, Clausen H, Hartwig JH, Wandall HH, Hoffmeister KM. Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. Blood. 2009 Aug 20; 114(8):1645-54.
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  32. Bernimoulin M, Waters EK, Foy M, Steele BM, Sullivan M, Falet H, Walsh MT, Barteneva N, Geng JG, Hartwig JH, Maguire PB, Wagner DD. Differential stimulation of monocytic cells results in distinct populations of microparticles. J Thromb Haemost. 2009 Jun; 7(6):1019-28.
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  33. Adamovich DA, Nakamura F, Worth A, Burns S, Thrasher AJ, Hartwig JH, Snapper SB. Activating mutations of N-WASP alter Shigella pathogenesis. Biochem Biophys Res Commun. 2009 Jul 3; 384(3):284-9.
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  34. Le Bras S, Massaad M, Koduru S, Kumar L, Oyoshi MK, Hartwig J, Geha RS. WIP is critical for T cell responsiveness to IL-2. Proc Natl Acad Sci U S A. 2009 May 5; 106(18):7519-24.
    View in: PubMed
  35. Nakamura F, Heikkinen O, Pentikäinen OT, Osborn TM, Kasza KE, Weitz DA, Kupiainen O, Permi P, Kilpeläinen I, Ylänne J, Hartwig JH, Stossel TP. Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations. PLoS One. 2009; 4(3):e4928.
    View in: PubMed
  36. Wang Y, Chen X, Lian L, Tang T, Stalker TJ, Sasaki T, Kanaho Y, Brass LF, Choi JK, Hartwig JH, Abrams CS. Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14064-9.
    View in: PubMed
  37. Randhawa VK, Ishikura S, Talior-Volodarsky I, Cheng AW, Patel N, Hartwig JH, Klip A. GLUT4 vesicle recruitment and fusion are differentially regulated by Rac, AS160, and Rab8A in muscle cells. J Biol Chem. 2008 Oct 3; 283(40):27208-19.
    View in: PubMed
  38. Salomao M, Zhang X, Yang Y, Lee S, Hartwig JH, Chasis JA, Mohandas N, An X. Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):8026-31.
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  39. Wang Y, Litvinov RI, Chen X, Bach TL, Lian L, Petrich BG, Monkley SJ, Kanaho Y, Critchley DR, Sasaki T, Birnbaum MJ, Weisel JW, Hartwig J, Abrams CS. Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. J Clin Invest. 2008 Feb; 118(2):812-9.
    View in: PubMed
  40. Patel-Hett S, Richardson JL, Schulze H, Drabek K, Isaac NA, Hoffmeister K, Shivdasani RA, Bulinski JC, Galjart N, Hartwig JH, Italiano JE. Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules. Blood. 2008 May 1; 111(9):4605-16.
    View in: PubMed
  41. Wandall HH, Hoffmeister KM, Sørensen AL, Rumjantseva V, Clausen H, Hartwig JH, Slichter SJ. Galactosylation does not prevent the rapid clearance of long-term, 4 degrees C-stored platelets. Blood. 2008 Mar 15; 111(6):3249-56.
    View in: PubMed
  42. Nakamura F, Osborn TM, Hartemink CA, Hartwig JH, Stossel TP. Structural basis of filamin A functions. J Cell Biol. 2007 Dec 3; 179(5):1011-25.
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  43. Bai J, Hartwig JH, Perrimon N. SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. Dev Cell. 2007 Dec; 13(6):828-42.
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  44. Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, Pollak MR. Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A. 2007 Oct 9; 104(41):16080-5.
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  45. Battinelli EM, Hartwig JH, Italiano JE. Delivering new insight into the biology of megakaryopoiesis and thrombopoiesis. Curr Opin Hematol. 2007 Sep; 14(5):419-26.
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  46. Italiano JE, Patel-Hett S, Hartwig JH. Mechanics of proplatelet elaboration. J Thromb Haemost. 2007 Jul; 5 Suppl 1:18-23.
    View in: PubMed
  47. Babic AM, Josefsson EC, Bergmeier W, Wagner DD, Kaufman RM, Silberstein LE, Stossel TP, Hartwig JH, Hoffmeister KM. In vitro function and phagocytosis of galactosylated platelet concentrates after long-term refrigeration. Transfusion. 2007 Mar; 47(3):442-51.
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  48. Osborn TM, Dahlgren C, Hartwig JH, Stossel TP. Modifications of cellular responses to lysophosphatidic acid and platelet-activating factor by plasma gelsolin. Am J Physiol Cell Physiol. 2007 Apr; 292(4):C1323-30.
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  49. Stossel TP, Fenteany G, Hartwig JH. Cell surface actin remodeling. J Cell Sci. 2006 Aug 15; 119(Pt 16):3261-4.
    View in: PubMed
  50. Kalfa TA, Pushkaran S, Mohandas N, Hartwig JH, Fowler VM, Johnson JF, Joiner CH, Williams DA, Zheng Y. Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood. 2006 Dec 1; 108(12):3637-45.
    View in: PubMed
  51. Ohta Y, Hartwig JH, Stossel TP. FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling. Nat Cell Biol. 2006 Aug; 8(8):803-14.
    View in: PubMed
  52. Gardel ML, Nakamura F, Hartwig J, Crocker JC, Stossel TP, Weitz DA. Stress-dependent elasticity of composite actin networks as a model for cell behavior. Phys Rev Lett. 2006 Mar 3; 96(8):088102.
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  53. Hartwig JH, Italiano JE. Cytoskeletal mechanisms for platelet production. Blood Cells Mol Dis. 2006 Mar-Apr; 36(2):99-103.
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  54. Gardel ML, Nakamura F, Hartwig JH, Crocker JC, Stossel TP, Weitz DA. Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Proc Natl Acad Sci U S A. 2006 Feb 7; 103(6):1762-7.
    View in: PubMed
  55. Hartwig JH. The platelet: form and function. Semin Hematol. 2006 Jan; 43(1 Suppl 1):S94-100.
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  56. Patel SR, Hartwig JH, Italiano JE. The biogenesis of platelets from megakaryocyte proplatelets. J Clin Invest. 2005 Dec; 115(12):3348-54.
    View in: PubMed
  57. Nakamura F, Pudas R, Heikkinen O, Permi P, Kilpeläinen I, Munday AD, Hartwig JH, Stossel TP, Ylänne J. The structure of the GPIb-filamin A complex. Blood. 2006 Mar 1; 107(5):1925-32.
    View in: PubMed
  58. Di Nardo A, Cicchetti G, Falet H, Hartwig JH, Stossel TP, Kwiatkowski DJ. Arp2/3 complex-deficient mouse fibroblasts are viable and have normal leading-edge actin structure and function. Proc Natl Acad Sci U S A. 2005 Nov 8; 102(45):16263-8.
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  59. Osborn EA, Rabodzey A, Dewey CF, Hartwig JH. Endothelial actin cytoskeleton remodeling during mechanostimulation with fluid shear stress. Am J Physiol Cell Physiol. 2006 Feb; 290(2):C444-52.
    View in: PubMed
  60. Patel SR, Richardson JL, Schulze H, Kahle E, Galjart N, Drabek K, Shivdasani RA, Hartwig JH, Italiano JE. Differential roles of microtubule assembly and sliding in proplatelet formation by megakaryocytes. Blood. 2005 Dec 15; 106(13):4076-85.
    View in: PubMed
  61. Richardson JL, Shivdasani RA, Boers C, Hartwig JH, Italiano JE. Mechanisms of organelle transport and capture along proplatelets during platelet production. Blood. 2005 Dec 15; 106(13):4066-75.
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  62. Nakamura F, Hartwig JH, Stossel TP, Szymanski PT. Ca2+ and calmodulin regulate the binding of filamin A to actin filaments. J Biol Chem. 2005 Sep 16; 280(37):32426-33.
    View in: PubMed
  63. Falet H, Chang G, Brohard-Bohn B, Rendu F, Hartwig JH. Integrin alpha(IIb)beta3 signals lead cofilin to accelerate platelet actin dynamics. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C819-25.
    View in: PubMed
  64. Josefsson EC, Gebhard HH, Stossel TP, Hartwig JH, Hoffmeister KM. The macrophage alphaMbeta2 integrin alphaM lectin domain mediates the phagocytosis of chilled platelets. J Biol Chem. 2005 May 6; 280(18):18025-32.
    View in: PubMed
  65. Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V. Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2. Oncogene. 2004 Nov 18; 23(54):8815-25.
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  66. Rodal AA, Kozubowski L, Goode BL, Drubin DG, Hartwig JH. Actin and septin ultrastructures at the budding yeast cell cortex. Mol Biol Cell. 2005 Jan; 16(1):372-84.
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  67. Kettner A, Kumar L, Antón IM, Sasahara Y, de la Fuente M, Pivniouk VI, Falet H, Hartwig JH, Geha RS. WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells. J Exp Med. 2004 Feb 2; 199(3):357-68.
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  68. Sobocka MB, Sobocki T, Babinska A, Hartwig JH, Li M, Ehrlich YH, Kornecki E. Signaling pathways of the F11 receptor (F11R; a.k.a. JAM-1, JAM-A) in human platelets: F11R dimerization, phosphorylation and complex formation with the integrin GPIIIa. J Recept Signal Transduct Res. 2004 Feb; 24(1-2):85-105.
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  69. Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS. Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells. Int Immunol. 2003 Dec; 15(12):1431-40.
    View in: PubMed
  70. Hoffmeister KM, Josefsson EC, Isaac NA, Clausen H, Hartwig JH, Stossel TP. Glycosylation restores survival of chilled blood platelets. Science. 2003 Sep 12; 301(5639):1531-4.
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  71. Bergmeier W, Burger PC, Piffath CL, Hoffmeister KM, Hartwig JH, Nieswandt B, Wagner DD. Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse platelets. Blood. 2003 Dec 1; 102(12):4229-35.
    View in: PubMed
  72. Hartwig J, Italiano J. The birth of the platelet. J Thromb Haemost. 2003 Jul; 1(7):1580-6.
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  73. Barkalow KL, Falet H, Italiano JE, van Vugt A, Carpenter CL, Schreiber AD, Hartwig JH. Role for phosphoinositide 3-kinase in Fc gamma RIIA-induced platelet shape change. Am J Physiol Cell Physiol. 2003 Oct; 285(4):C797-805.
    View in: PubMed
  74. Barkalow KL, Italiano JE, Chou DE, Matsuoka Y, Bennett V, Hartwig JH. Alpha-adducin dissociates from F-actin and spectrin during platelet activation. J Cell Biol. 2003 May 12; 161(3):557-70.
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  75. Paul BZ, Kim S, Dangelmaier C, Nagaswami C, Jin J, Hartwig JH, Weisel JW, Daniel JL, Kunapuli SP. Dynamic regulation of microtubule coils in ADP-induced platelet shape change by p160ROCK (Rho-kinase). Platelets. 2003 May; 14(3):159-69.
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  76. Antón IM, Saville SP, Byrne MJ, Curcio C, Ramesh N, Hartwig JH, Geha RS. WIP participates in actin reorganization and ruffle formation induced by PDGF. J Cell Sci. 2003 Jun 15; 116(Pt 12):2443-51.
    View in: PubMed
  77. Stossel TP, Hartwig JH. Filling gaps in signaling to actin cytoskeletal remodeling. Dev Cell. 2003 Apr; 4(4):444-5.
    View in: PubMed
  78. Italiano JE, Bergmeier W, Tiwari S, Falet H, Hartwig JH, Hoffmeister KM, André P, Wagner DD, Shivdasani RA. Mechanisms and implications of platelet discoid shape. Blood. 2003 Jun 15; 101(12):4789-96.
    View in: PubMed
  79. Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH. The clearance mechanism of chilled blood platelets. Cell. 2003 Jan 10; 112(1):87-97.
    View in: PubMed
  80. Falet H, Hoffmeister KM, Neujahr R, Italiano JE, Stossel TP, Southwick FS, Hartwig JH. Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):16782-7.
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  81. Falet H, Hoffmeister KM, Neujahr R, Hartwig JH. Normal Arp2/3 complex activation in platelets lacking WASp. Blood. 2002 Sep 15; 100(6):2113-22.
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  82. Antón IM, de la Fuente MA, Sims TN, Freeman S, Ramesh N, Hartwig JH, Dustin ML, Geha RS. WIP deficiency reveals a differential role for WIP and the actin cytoskeleton in T and B cell activation. Immunity. 2002 Feb; 16(2):193-204.
    View in: PubMed
  83. Flanagan LA, Chou J, Falet H, Neujahr R, Hartwig JH, Stossel TP. Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol. 2001 Nov 12; 155(4):511-7.
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  84. Snapper SB, Takeshima F, Antón I, Liu CH, Thomas SM, Nguyen D, Dudley D, Fraser H, Purich D, Lopez-Ilasaca M, Klein C, Davidson L, Bronson R, Mulligan RC, Southwick F, Geha R, Goldberg MB, Rosen FS, Hartwig JH, Alt FW. N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol. 2001 Oct; 3(10):897-904.
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  85. Cunningham CC, Vegners R, Bucki R, Funaki M, Korde N, Hartwig JH, Stossel TP, Janmey PA. Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J Biol Chem. 2001 Nov 16; 276(46):43390-9.
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  86. James MF, Manchanda N, Gonzalez-Agosti C, Hartwig JH, Ramesh V. The neurofibromatosis 2 protein product merlin selectively binds F-actin but not G-actin, and stabilizes the filaments through a lateral association. Biochem J. 2001 Jun 1; 356(Pt 2):377-86.
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  87. Hartwig J. Transfusion medicine illustrated. The human blood platelet, resting and active. Transfusion. 2001 Jun; 41(6):723.
    View in: PubMed
  88. Martinez-Quiles N, Rohatgi R, Antón IM, Medina M, Saville SP, Miki H, Yamaguchi H, Takenawa T, Hartwig JH, Geha RS, Ramesh N. WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat Cell Biol. 2001 May; 3(5):484-91.
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  89. Hoffmeister KM, Falet H, Toker A, Barkalow KL, Stossel TP, Hartwig JH. Mechanisms of cold-induced platelet actin assembly. J Biol Chem. 2001 Jul 6; 276(27):24751-9.
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  90. Schwer HD, Lecine P, Tiwari S, Italiano JE, Hartwig JH, Shivdasani RA. A lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets. Curr Biol. 2001 Apr 17; 11(8):579-86.
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  91. Stossel TP, Condeelis J, Cooley L, Hartwig JH, Noegel A, Schleicher M, Shapiro SS. Filamins as integrators of cell mechanics and signalling. Nat Rev Mol Cell Biol. 2001 Feb; 2(2):138-45.
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  92. Falet H, Barkalow KL, Pivniouk VI, Barnes MJ, Geha RS, Hartwig JH. Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcR gamma-chain complex. Blood. 2000 Dec 1; 96(12):3786-92.
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  93. McGrath JL, Hartwig JH, Kuo SC. The mechanics of F-actin microenvironments depend on the chemistry of probing surfaces. Biophys J. 2000 Dec; 79(6):3258-66.
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  94. Glogauer M, Hartwig J, Stossel T. Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils. J Cell Biol. 2000 Aug 21; 150(4):785-96.
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  95. McGrath JL, Osborn EA, Tardy YS, Dewey CF, Hartwig JH. Regulation of the actin cycle in vivo by actin filament severing. Proc Natl Acad Sci U S A. 2000 Jun 6; 97(12):6532-7.
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  96. Frenette PS, Denis CV, Weiss L, Jurk K, Subbarao S, Kehrel B, Hartwig JH, Vestweber D, Wagner DD. P-Selectin glycoprotein ligand 1 (PSGL-1) is expressed on platelets and can mediate platelet-endothelial interactions in vivo. J Exp Med. 2000 Apr 17; 191(8):1413-22.
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  97. Sobocka MB, Sobocki T, Banerjee P, Weiss C, Rushbrook JI, Norin AJ, Hartwig J, Salifu MO, Markell MS, Babinska A, Ehrlich YH, Kornecki E. Cloning of the human platelet F11 receptor: a cell adhesion molecule member of the immunoglobulin superfamily involved in platelet aggregation. Blood. 2000 Apr 15; 95(8):2600-9.
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  98. Tolias KF, Hartwig JH, Ishihara H, Shibasaki Y, Cantley LC, Carpenter CL. Type Ialpha phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly. Curr Biol. 2000 Feb 10; 10(3):153-6.
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  99. Azim AC, Barkalow K, Chou J, Hartwig JH. Activation of the small GTPases, rac and cdc42, after ligation of the platelet PAR-1 receptor. Blood. 2000 Feb 1; 95(3):959-64.
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  100. Azim AC, Barkalow KL, Hartwig JH. Determination of GTP loading on Rac and Cdc42 in platelets and fibroblasts. Methods Enzymol. 2000; 325:257-63.
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  101. Cheng Y, Hartemink CA, Hartwig JH, Dewey CF. Three-dimensional reconstruction of the actin cytoskeleton from stereo images. J Biomech. 2000 Jan; 33(1):105-13.
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  102. Hartwig JH, Barkalow KL. Actin filament assembly in permeabilized platelets. Methods Enzymol. 2000; 325:349-56.
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  103. Italiano JE, Lecine P, Shivdasani RA, Hartwig JH. Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol. 1999 Dec 13; 147(6):1299-312.
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  104. Hartwig JH, Barkalow K, Azim A, Italiano J. The elegant platelet: signals controlling actin assembly. Thromb Haemost. 1999 Aug; 82(2):392-8.
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  105. Ohta Y, Suzuki N, Nakamura S, Hartwig JH, Stossel TP. The small GTPase RalA targets filamin to induce filopodia. Proc Natl Acad Sci U S A. 1999 Mar 2; 96(5):2122-8.
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  106. Carpenter CL, Tolias KF, Van Vugt A, Hartwig J. Lipid kinases are novel effectors of the GTPase Rac1. Adv Enzyme Regul. 1999; 39:299-312.
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  107. Stossel TP, Hartwig JH, Janmey PA, Kwiatkowski DJ. Cell crawling two decades after Abercrombie. Biochem Soc Symp. 1999; 65:267-80.
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  108. McGrath JL, Hartwig JH, Tardy Y, Dewey CF. Measuring actin dynamics in endothelial cells. Microsc Res Tech. 1998 Dec 1; 43(5):385-94.
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  109. Geng YJ, Azuma T, Tang JX, Hartwig JH, Muszynski M, Wu Q, Libby P, Kwiatkowski DJ. Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines. Eur J Cell Biol. 1998 Dec; 77(4):294-302.
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  110. McGrath JL, Tardy Y, Dewey CF, Meister JJ, Hartwig JH. Simultaneous measurements of actin filament turnover, filament fraction, and monomer diffusion in endothelial cells. Biophys J. 1998 Oct; 75(4):2070-8.
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  111. Howard TH, Hartwig J, Cunningham C. Lymphocyte-specific protein 1 expression in eukaryotic cells reproduces the morphologic and motile abnormality of NAD 47/89 neutrophils. Blood. 1998 Jun 15; 91(12):4786-95.
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  112. Azuma T, Witke W, Stossel TP, Hartwig JH, Kwiatkowski DJ. Gelsolin is a downstream effector of rac for fibroblast motility. EMBO J. 1998 Mar 2; 17(5):1362-70.
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  113. Liu G, Thomas L, Warren RA, Enns CA, Cunningham CC, Hartwig JH, Thomas G. Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J Cell Biol. 1997 Dec 29; 139(7):1719-33.
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  114. Ramesh N, Antón IM, Hartwig JH, Geha RS. WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14671-6.
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  115. Satcher R, Dewey CF, Hartwig JH. Mechanical remodeling of the endothelial surface and actin cytoskeleton induced by fluid flow. Microcirculation. 1997 Dec; 4(4):439-53.
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  116. Hartwig JH, Barkalow K. Polyphosphoinositide synthesis and platelet shape change. Curr Opin Hematol. 1997 Sep; 4(5):351-6.
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  117. Derman MP, Toker A, Hartwig JH, Spokes K, Falck JR, Chen CS, Cantley LC, Cantley LG. The lipid products of phosphoinositide 3-kinase increase cell motility through protein kinase C. J Biol Chem. 1997 Mar 7; 272(10):6465-70.
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  118. Wientjes FB, Segal AW, Hartwig JH. Immunoelectron microscopy shows a clustered distribution of NADPH oxidase components in the human neutrophil plasma membrane. J Leukoc Biol. 1997 Mar; 61(3):303-12.
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  119. Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel TP, Kyriakis JM, Avruch J. Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells. J Biol Chem. 1997 Jan 31; 272(5):2620-8.
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  120. Meyer SC, Zuerbig S, Cunningham CC, Hartwig JH, Bissell T, Gardner K, Fox JE. Identification of the region in actin-binding protein that binds to the cytoplasmic domain of glycoprotein IBalpha. J Biol Chem. 1997 Jan 31; 272(5):2914-9.
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  121. Carpenter CL, Tolias KF, Couvillon AC, Hartwig JH. Signal transduction pathways involving the small G proteins rac and Cdc42 and phosphoinositide kinases. Adv Enzyme Regul. 1997; 37:377-90.
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  122. Hartwig JH, Kung S, Kovacsovics T, Janmey PA, Cantley LC, Stossel TP, Toker A. D3 phosphoinositides and outside-in integrin signaling by glycoprotein IIb-IIIa mediate platelet actin assembly and filopodial extension induced by phorbol 12-myristate 13-acetate. J Biol Chem. 1996 Dec 20; 271(51):32986-93.
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  123. Barkalow K, Witke W, Kwiatkowski DJ, Hartwig JH. Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein. J Cell Biol. 1996 Jul; 134(2):389-99.
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  124. Leterrier JF, Käs J, Hartwig J, Vegners R, Janmey PA. Mechanical effects of neurofilament cross-bridges. Modulation by phosphorylation, lipids, and interactions with F-actin. J Biol Chem. 1996 Jun 28; 271(26):15687-94.
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  125. Ohta Y, Hartwig JH. Phosphorylation of actin-binding protein 280 by growth factors is mediated by p90 ribosomal protein S6 kinase. J Biol Chem. 1996 May 17; 271(20):11858-64.
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  126. Cox D, Wessels D, Soll DR, Hartwig J, Condeelis J. Re-expression of ABP-120 rescues cytoskeletal, motility, and phagocytosis defects of ABP-120- Dictyostelium mutants. Mol Biol Cell. 1996 May; 7(5):803-23.
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  127. Kovacsovics TJ, Hartwig JH. Thrombin-induced GPIb-IX centralization on the platelet surface requires actin assembly and myosin II activation. Blood. 1996 Jan 15; 87(2):618-29.
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  128. Kieffer JD, Plopper G, Ingber DE, Hartwig JH, Kupper TS. Direct binding of F actin to the cytoplasmic domain of the alpha 2 integrin chain in vitro. Biochem Biophys Res Commun. 1995 Dec 14; 217(2):466-74.
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  129. Toker A, Bachelot C, Chen CS, Falck JR, Hartwig JH, Cantley LC, Kovacsovics TJ. Phosphorylation of the platelet p47 phosphoprotein is mediated by the lipid products of phosphoinositide 3-kinase. J Biol Chem. 1995 Dec 8; 270(49):29525-31.
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  130. Tardy Y, McGrath JL, Hartwig JH, Dewey CF. Interpreting photoactivated fluorescence microscopy measurements of steady-state actin dynamics. Biophys J. 1995 Nov; 69(5):1674-82.
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  131. Hartwig JH, Jugloff LS, De Groot NJ, Grupp SA, Jongstra-Bilen J. The ligand-induced membrane IgM association with the cytoskeletal matrix of B cells is not mediated through the Ig alpha beta heterodimer. J Immunol. 1995 Oct 15; 155(8):3769-79.
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  132. Barkalow K, Hartwig JH. Actin cytoskeleton. Setting the pace of cell movement. Curr Biol. 1995 Sep 1; 5(9):1000-2.
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  133. Hartwig JH, Bokoch GM, Carpenter CL, Janmey PA, Taylor LA, Toker A, Stossel TP. Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell. 1995 Aug 25; 82(4):643-53.
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  134. Barkalow K, Hartwig JH. The role of actin filament barbed-end exposure in cytoskeletal dynamics and cell motility. Biochem Soc Trans. 1995 Aug; 23(3):451-6.
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  135. Ohta Y, Hartwig JH. Actin filament cross-linking by chicken gizzard filamin is regulated by phosphorylation in vitro. Biochemistry. 1995 May 23; 34(20):6745-54.
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  136. Kovacsovics TJ, Bachelot C, Toker A, Vlahos CJ, Duckworth B, Cantley LC, Hartwig JH. Phosphoinositide 3-kinase inhibition spares actin assembly in activating platelets but reverses platelet aggregation. J Biol Chem. 1995 May 12; 270(19):11358-66.
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  137. Witke W, Sharpe AH, Hartwig JH, Azuma T, Stossel TP, Kwiatkowski DJ. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell. 1995 Apr 7; 81(1):41-51.
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  138. Winokur R, Hartwig JH. Mechanism of shape change in chilled human platelets. Blood. 1995 Apr 1; 85(7):1796-804.
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  139. Cox D, Ridsdale JA, Condeelis J, Hartwig J. Genetic deletion of ABP-120 alters the three-dimensional organization of actin filaments in Dictyostelium pseudopods. J Cell Biol. 1995 Mar; 128(5):819-35.
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  140. Hartwig JH. Actin-binding proteins. 1: Spectrin super family. Protein Profile. 1995; 2(7):703-800.
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  141. Lo SH, An Q, Bao S, Wong WK, Liu Y, Janmey PA, Hartwig JH, Chen LB. Molecular cloning of chick cardiac muscle tensin. Full-length cDNA sequence, expression, and characterization. J Biol Chem. 1994 Sep 2; 269(35):22310-9.
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  142. Hitt AL, Hartwig JH, Luna EJ. Ponticulin is the major high affinity link between the plasma membrane and the cortical actin network in Dictyostelium. J Cell Biol. 1994 Sep; 126(6):1433-44.
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  143. Lo SH, Janmey PA, Hartwig JH, Chen LB. Interactions of tensin with actin and identification of its three distinct actin-binding domains. J Cell Biol. 1994 Jun; 125(5):1067-75.
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  144. Hartwig JH. Actin-binding proteins 1: spectrin superfamily. Protein Profile. 1994; 1(7):706-78.
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  145. Gorlin JB, Henske E, Warren ST, Kunst CB, D'Urso M, Palmieri G, Hartwig JH, Bruns G, Kwiatkowski DJ. Actin-binding protein (ABP-280) filamin gene (FLN) maps telomeric to the color vision locus (R/GCP) and centromeric to G6PD in Xq28. Genomics. 1993 Aug; 17(2):496-8.
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  146. Cantiello HF, Prat AG, Bonventre JV, Cunningham CC, Hartwig JH, Ausiello DA. Actin-binding protein contributes to cell volume regulatory ion channel activation in melanoma cells. J Biol Chem. 1993 Mar 5; 268(7):4596-9.
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  147. Jongstra-Bilen J, Janmey PA, Hartwig JH, Galea S, Jongstra J. The lymphocyte-specific protein LSP1 binds to F-actin and to the cytoskeleton through its COOH-terminal basic domain. J Cell Biol. 1992 Sep; 118(6):1443-53.
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  148. Hartwig JH. Mechanisms of actin rearrangements mediating platelet activation. J Cell Biol. 1992 Sep; 118(6):1421-42.
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  149. Katakami Y, Katakami N, Janmey PA, Hartwig JH, Stossel TP. Isolation of the phosphatidylinositol 4-monophosphate dissociable high-affinity profilin-actin complex. Biochim Biophys Acta. 1992 Jul 31; 1122(2):123-35.
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  150. Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC, Aderem A. MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature. 1992 Apr 16; 356(6370):618-22.
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  151. Cunningham CC, Gorlin JB, Kwiatkowski DJ, Hartwig JH, Janmey PA, Byers HR, Stossel TP. Actin-binding protein requirement for cortical stability and efficient locomotion. Science. 1992 Jan 17; 255(5042):325-7.
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  152. Ohta Y, Stossel TP, Hartwig JH. Ligand-sensitive binding of actin-binding protein to immunoglobulin G Fc receptor I (Fc gamma RI). Cell. 1991 Oct 18; 67(2):275-82.
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  153. Hartwig JH, DeSisto M. The cytoskeleton of the resting human blood platelet: structure of the membrane skeleton and its attachment to actin filaments. J Cell Biol. 1991 Feb; 112(3):407-25.
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  154. Hartwig JH, Kwiatkowski DJ. Actin-binding proteins. Curr Opin Cell Biol. 1991 Feb; 3(1):87-97.
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  155. Janmey PA, Hvidt S, Oster GF, Lamb J, Stossel TP, Hartwig JH. Effect of ATP on actin filament stiffness. Nature. 1990 Sep 6; 347(6288):95-9.
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  156. Gorlin JB, Yamin R, Egan S, Stewart M, Stossel TP, Kwiatkowski DJ, Hartwig JH. Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J Cell Biol. 1990 Sep; 111(3):1089-105.
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  157. Hartwig JH, Brown D, Ausiello DA, Stossel TP, Orci L. Polarization of gelsolin and actin binding protein in kidney epithelial cells. J Histochem Cytochem. 1990 Aug; 38(8):1145-53.
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  158. Holtz D, Tanaka RA, Hartwig J, McKeon F. The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope. Cell. 1989 Dec 22; 59(6):969-77.
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  159. Hartwig JH, Chambers KA, Hopcia KL, Kwiatkowski DJ. Association of profilin with filament-free regions of human leukocyte and platelet membranes and reversible membrane binding during platelet activation. J Cell Biol. 1989 Oct; 109(4 Pt 1):1571-9.
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  160. Sixma JJ, van den Berg A, Jockusch BM, Hartwig J. Immunoelectron microscopic localization of actin, alpha-actinin, actin-binding protein and myosin in resting and activated human blood platelets. Eur J Cell Biol. 1989 Apr; 48(2):271-81.
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  161. Hartwig JH, Chambers KA, Stossel TP. Association of gelsolin with actin filaments and cell membranes of macrophages and platelets. J Cell Biol. 1989 Feb; 108(2):467-79.
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  162. Hartwig JH, Janmey PA. Stimulation of a calcium-dependent actin nucleation activity by phorbol 12-myristate 13-acetate in rabbit macrophage cytoskeletons. Biochim Biophys Acta. 1989 Jan 17; 1010(1):64-71.
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  163. Ezzell RM, Kenney DM, Egan S, Stossel TP, Hartwig JH. Localization of the domain of actin-binding protein that binds to membrane glycoprotein Ib and actin in human platelets. J Biol Chem. 1988 Sep 15; 263(26):13303-9.
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  164. Zaner KS, Hartwig JH. The effect of filament shortening on the mechanical properties of gel-filtered actin. J Biol Chem. 1988 Apr 5; 263(10):4532-6.
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  165. Hartwig JH, Zaner KS, Janmey PA. The cortical actin gel of macrophages. Soc Gen Physiol Ser. 1988; 43:125-40.
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  166. Hartwig JH, Yin HL. The organization and regulation of the macrophage actin skeleton. Cell Motil Cytoskeleton. 1988; 10(1-2):117-25.
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  167. Yin HL, Hartwig JH. The structure of the macrophage actin skeleton. J Cell Sci Suppl. 1988; 9:169-84.
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  168. Hartwig JH, Ausiello DA, Brown D. Vasopressin-induced changes in the three-dimensional structure of toad bladder apical surface. Am J Physiol. 1987 Nov; 253(5 Pt 1):C707-20.
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  169. Brown D, Gluck S, Hartwig J. Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase. J Cell Biol. 1987 Oct; 105(4):1637-48.
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  170. Ausiello DA, Hartwig J, Brown D. Membrane and microfilament organization and vasopressin action in transporting epithelia. Soc Gen Physiol Ser. 1987; 42:259-75.
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  171. Jack RM, Ezzell RM, Hartwig J, Fearon DT. Differential interaction of the C3b/C4b receptor and MHC class I with the cytoskeleton of human neutrophils. J Immunol. 1986 Dec 15; 137(12):3996-4003.
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  172. Hartwig JH, Shevlin P. The architecture of actin filaments and the ultrastructural location of actin-binding protein in the periphery of lung macrophages. J Cell Biol. 1986 Sep; 103(3):1007-20.
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  173. Hartwig JH. Actin filament architecture and movements in macrophage cytoplasm. Ciba Found Symp. 1986; 118:42-53.
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  174. Stossel TP, Chaponnier C, Ezzell RM, Hartwig JH, Janmey PA, Kwiatkowski DJ, Lind SE, Smith DB, Southwick FS, Yin HL, et al. Nonmuscle actin-binding proteins. Annu Rev Cell Biol. 1985; 1:353-402.
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  175. Hartwig JH, Niederman R, Lind SE. Cortical actin structures and their relationship to mammalian cell movements. Subcell Biochem. 1985; 11:1-49.
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  176. Stossel TP, Hartwig JH, Yin HL, Southwick FS, Zaner KS. The motor of leukocytes. Fed Proc. 1984 Sep; 43(12):2760-3.
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  177. Ausiello DA, Corwin HL, Hartwig JH. Identification of actin-binding protein and villin in toad bladder epithelia. Am J Physiol. 1984 Jan; 246(1 Pt 2):F101-4.
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  178. Corwin HL, Hartwig JH. Isolation of actin-binding protein and villin from toad oocytes. Dev Biol. 1983 Sep; 99(1):61-74.
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  179. Hartwig JH, Yin HL, Stossel TP. How phagocytic leukocytes move. J Clin Chem Clin Biochem. 1983 Sep; 21(9):535-44.
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  180. Niederman R, Amrein PC, Hartwig J. Three-dimensional structure of actin filaments and of an actin gel made with actin-binding protein. J Cell Biol. 1983 May; 96(5):1400-13.
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  181. Fattoum A, Hartwig JH, Stossel TP. Isolation and some structural and functional properties of macrophage tropomyosin. Biochemistry. 1983 Mar 1; 22(5):1187-93.
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  182. Niederman R, Ryder MI, Horton JE, Sullivan T, Peters L, Hartwig J, Stossel TP. The cortical actin networks of migrating human PMNs. J Periodontal Res. 1982 Sep; 17(5):487-91.
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  183. Thorstensson R, Utter G, Norberg R, Fagraeus A, Hartwig JH, Yin HL, Stossel TP. Distribution of actin, myosin, actin-binding protein and gelsolin in cultured lymphoid cells. Exp Cell Res. 1982 Aug; 140(2):395-400.
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  184. Southwick FS, Hartwig JH. Acumentin, a protein in macrophages which caps the "pointed" end of action filaments. Nature. 1982 May 27; 297(5864):303-7.
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  185. Valerius NH, Stendahl OI, Hartwig JH, Stossel TP. Distribution of actin-binding protein and myosin in neutrophils during chemotaxis and phagocytosis. Adv Exp Med Biol. 1982; 141:19-28.
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  186. Stossel TP, Hartwig JH, Yin HL, Zaner KS, Stendahl OI. Actin gelation and structure of cortical cytoplasm. Cold Spring Harb Symp Quant Biol. 1982; 46 Pt 2:569-78.
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  187. Hartwig JH, Stossel TP. Macrophage actin-binding protein. Methods Enzymol. 1982; 85 Pt B:480-8.
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  188. Hartwig JH, Stossel TP. Macrophages: their use in elucidation of the cytoskeletal roles of actin. Methods Cell Biol. 1982; 25 Pt B:201-25.
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  189. Yin HL, Hartwig JH, Maruyama K, Stossel TP. Ca2+ control of actin filament length. Effects of macrophage gelsolin on actin polymerization. J Biol Chem. 1981 Sep 25; 256(18):9693-7.
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  190. Valerius NH, Stendahl O, Hartwig JH, Stossel TP. Distribution of actin-binding protein and myosin in polymorphonuclear leukocytes during locomotion and phagocytosis. Cell. 1981 Apr; 24(1):195-202.
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  191. Hartwig JH, Stossel TP. Structure of macrophage actin-binding protein molecules in solution and interacting with actin filaments. J Mol Biol. 1981 Jan 25; 145(3):563-81.
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  192. Maruyama K, Hartwig JH, Stossel TP. Cytochalasin B and the structure of actin gels. II. Further evidence for the splitting of F-actin by cytochalasin B. Biochim Biophys Acta. 1980 Dec 16; 626(2):494-500.
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  193. Hartwig JH, Tyler J, Stossel TP. Actin-binding protein promotes the bipolar and perpendicular branching of actin filaments. J Cell Biol. 1980 Dec; 87(3 Pt 1):841-8.
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  194. Stendahl OI, Hartwig JH, Brotschi EA, Stossel TP. Distribution of actin-binding protein and myosin in macrophages during spreading and phagocytosis. J Cell Biol. 1980 Feb; 84(2):215-24.
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  195. Stossel TP, Hartwig JH, Yin HL, Stendahl O. The motor of amoeboid leucocytes. Biochem Soc Symp. 1980; 45:51-63.
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  196. Hartwig JH, Stossel TP. Cytochalasin B and the structure of actin gels. J Mol Biol. 1979 Nov 5; 134(3):539-53.
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  197. Brotschi EA, Hartwig JH, Stossel TP. The gelation of actin by actin-binding protein. J Biol Chem. 1978 Dec 25; 253(24):8988-93.
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  198. Hartwig JH, Davies WA, Stossel TP. Evidence for contractile protein translocation in macrophage spreading, phagocytosis, and phagolysosome formation. J Cell Biol. 1977 Dec; 75(3):956-67.
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  199. Hartwig JH, Stossel TP. Interactions of actin, myosin, and an actin-binding protein of rabbit pulmonary macrophages. III. Effects of cytochalasin B. J Cell Biol. 1976 Oct; 71(1):295-303.
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  200. Stossel TP, Hartwig JH. Interactions of actin, myosin, and a new actin-binding protein of rabbit pulmonary macrophages. II. Role in cytoplasmic movement and phagocytosis. J Cell Biol. 1976 Mar; 68(3):602-19.
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  201. Hartwig JH, Stossel TP. Isolation and properties of actin, myosin, and a new actinbinding protein in rabbit alveolar macrophages. J Biol Chem. 1975 Jul 25; 250(14):5696-705.
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  202. Stossel TP, Hartwig JH. Interactions between actin, myosin, and an actin-binding protein from rabbit alveolar macrophages. Alveolar macrophage myosin Mg-2+-adenosine triphosphatase requires a cofactor for activation by actin. J Biol Chem. 1975 Jul 25; 250(14):5706-12.
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  203. Stossel TP, Mason RJ, Hartwig J, Vaughan M. Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis. J Clin Invest. 1972 Mar; 51(3):615-24.
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