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Tilo Winkler, PH.D.

TitleAssistant Professor of Anaesthesia
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMassachusetts General Hospital
Clinic 237
55 Fruit St
Boston MA 02114
Phone617/726-8832

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Saha D, Takahashi K, de Prost N, Winkler T, Pinilla-Vera M, Baron RM, Vidal Melo MF. Micro-autoradiographic assessment of cell types contributing to 2-deoxy-2-[(18)f]fluoro-d-glucose uptake during ventilator-induced and endotoxemic lung injury. Mol Imaging Biol. 2013 Feb; 15(1):19-27.
    View in: PubMed
  2. Harris RS, Fujii-Rios H, Winkler T, Musch G, Vidal Melo MF, Venegas JG. Ventilation defect formation in healthy and asthma subjects is determined by lung inflation. PLoS One. 2012; 7(12):e53216.
    View in: PubMed
  3. Dittrich AS, Winkler T, Wellman T, de Prost N, Musch G, Harris RS, Vidal Melo MF. Modeling (18)F-FDG Kinetics during Acute Lung Injury: Experimental Data and Estimation Errors. PLoS One. 2012; 7(10):e47588.
    View in: PubMed
  4. Venegas J, Winkler T, Harris RS. Lung physiology and aerosol deposition imaged with positron emission tomography. J Aerosol Med Pulm Drug Deliv. 2013 Feb; 26(1):1-8.
    View in: PubMed
  5. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Venegas JG, Vidal Melo MF. Effect of regional lung inflation on ventilation heterogeneity at different length scales during mechanical ventilation of normal sheep lungs. J Appl Physiol. 2012 Sep; 113(6):947-57.
    View in: PubMed
  6. Winkler T, Venegas JG. Are all airways equal? J Appl Physiol. 2012 May; 112(9):1431-2.
    View in: PubMed
  7. Harris RS, Venegas JG, Wongviriyawong C, Winkler T, Kone M, Musch G, Vidal Melo MF, de Prost N, Hamilos DL, Afshar R, Cho J, Luster AD, Medoff BD. 18F-FDG uptake rate is a biomarker of eosinophilic inflammation and airway response in asthma. J Nucl Med. 2011 Nov; 52(11):1713-20.
    View in: PubMed
  8. de Prost N, Costa EL, Wellman T, Musch G, Winkler T, Tucci MR, Harris RS, Venegas JG, Vidal Melo MF. Effects of surfactant depletion on regional pulmonary metabolic activity during mechanical ventilation. J Appl Physiol. 2011 Nov; 111(5):1249-58.
    View in: PubMed
  9. Winkler T, Venegas JG. Self-organized patterns of airway narrowing. J Appl Physiol. 2011 May; 110(5):1482-6.
    View in: PubMed
  10. Winkler T, Suki B. Emergent structure-function relations in emphysema and asthma. Crit Rev Biomed Eng. 2011; 39(4):263-80.
    View in: PubMed
  11. Wongviriyawong C, Winkler T, Harris RS, Venegas JG. Dynamics of tidal volume and ventilation heterogeneity under pressure-controlled ventilation during bronchoconstriction: a simulation study. J Appl Physiol. 2010 Oct; 109(4):1211-8.
    View in: PubMed
  12. Wellman TJ, Winkler T, Costa EL, Musch G, Harris RS, Venegas JG, Melo MF. Measurement of regional specific lung volume change using respiratory-gated PET of inhaled 13N-nitrogen. J Nucl Med. 2010 Apr; 51(4):646-53.
    View in: PubMed
  13. Costa EL, Musch G, Winkler T, Schroeder T, Harris RS, Jones HA, Venegas JG, Vidal Melo MF. Mild endotoxemia during mechanical ventilation produces spatially heterogeneous pulmonary neutrophilic inflammation in sheep. Anesthesiology. 2010 Mar; 112(3):658-69.
    View in: PubMed
  14. Vidal Melo MF, Winkler T, Harris RS, Musch G, Greene RE, Venegas JG. Spatial heterogeneity of lung perfusion assessed with (13)N PET as a vascular biomarker in chronic obstructive pulmonary disease. J Nucl Med. 2010 Jan; 51(1):57-65.
    View in: PubMed
  15. Harris RS, Winkler T, Musch G, Vidal Melo MF, Schroeder T, Tgavalekos N, Venegas JG. The prone position results in smaller ventilation defects during bronchoconstriction in asthma. J Appl Physiol. 2009 Jul; 107(1):266-74.
    View in: PubMed
  16. Schroeder T, Vidal Melo MF, Musch G, Harris RS, Venegas JG, Winkler T. Modeling pulmonary kinetics of 2-deoxy-2-[18F]fluoro-D-glucose during acute lung injury. Acad Radiol. 2008 Jun; 15(6):763-75.
    View in: PubMed
  17. Schroeder T, Vidal Melo MF, Musch G, Harris RS, Venegas JG, Winkler T. Image-derived input function for assessment of 18F-FDG uptake by the inflamed lung. J Nucl Med. 2007 Nov; 48(11):1889-96.
    View in: PubMed
  18. Musch G, Bellani G, Vidal Melo MF, Harris RS, Winkler T, Schroeder T, Venegas JG. Relation between shunt, aeration, and perfusion in experimental acute lung injury. Am J Respir Crit Care Med. 2008 Feb 1; 177(3):292-300.
    View in: PubMed
  19. Winkler T, Venegas JG. Complex airway behavior and paradoxical responses to bronchoprovocation. J Appl Physiol. 2007 Aug; 103(2):655-63.
    View in: PubMed
  20. Musch G, Venegas JG, Bellani G, Winkler T, Schroeder T, Petersen B, Harris RS, Melo MF. Regional gas exchange and cellular metabolic activity in ventilator-induced lung injury. Anesthesiology. 2007 Apr; 106(4):723-35.
    View in: PubMed
  21. Tgavalekos NT, Musch G, Harris RS, Vidal Melo MF, Winkler T, Schroeder T, Callahan R, Lutchen KR, Venegas JG. Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics. Eur Respir J. 2007 Jun; 29(6):1174-81.
    View in: PubMed
  22. Schroeder T, Vidal Melo MF, Musch G, Harris RS, Winkler T, Venegas JG. PET imaging of regional 18F-FDG uptake and lung function after cigarette smoke inhalation. J Nucl Med. 2007 Mar; 48(3):413-9.
    View in: PubMed
  23. Winkler T. In silico modeling of airway mechanics. Drug discovery today: disease models. 2007; in press.
  24. Winkler T. Sample title. sample publication. 2007; 111:1.
  25. Harris RS, Winkler T, Tgavalekos N, Musch G, Melo MF, Schroeder T, Chang Y, Venegas JG. Regional pulmonary perfusion, inflation, and ventilation defects in bronchoconstricted patients with asthma. Am J Respir Crit Care Med. 2006 Aug 1; 174(3):245-53.
    View in: PubMed
  26. Venegas JG, Schroeder T, Harris S, Winkler RT, Melo MF. The distribution of ventilation during bronchoconstriction is patchy and bimodal: a PET imaging study. Respir Physiol Neurobiol. 2005 Aug 25; 148(1-2):57-64.
    View in: PubMed
  27. Richter T, Bellani G, Scott Harris R, Vidal Melo MF, Winkler T, Venegas JG, Musch G. Effect of prone position on regional shunt, aeration, and perfusion in experimental acute lung injury. Am J Respir Crit Care Med. 2005 Aug 15; 172(4):480-7.
    View in: PubMed
  28. Venegas JG, Winkler T, Musch G, Vidal Melo MF, Layfield D, Tgavalekos N, Fischman AJ, Callahan RJ, Bellani G, Harris RS. Self-organized patchiness in asthma as a prelude to catastrophic shifts. Nature. 2005 Apr 7; 434(7034):777-82.
    View in: PubMed
  29. Musch G, Harris RS, Vidal Melo MF, O'Neill KR, Layfield JD, Winkler T, Venegas JG. Mechanism by which a sustained inflation can worsen oxygenation in acute lung injury. Anesthesiology. 2004 Feb; 100(2):323-30.
    View in: PubMed
  30. Vidal Melo MF, Layfield D, Harris RS, O'Neill K, Musch G, Richter T, Winkler T, Fischman AJ, Venegas JG. Quantification of regional ventilation-perfusion ratios with PET. J Nucl Med. 2003 Dec; 44(12):1982-91.
    View in: PubMed
  31. O'Neill K, Venegas JG, Richter T, Harris RS, Layfield JD, Musch G, Winkler T, Melo MF. Modeling kinetics of infused 13NN-saline in acute lung injury. J Appl Physiol. 2003 Dec; 95(6):2471-84.
    View in: PubMed
  32. Gama de Abreu M, Winkler T, Pahlitzsch T, Weismann D, Albrecht DM. Performance of the partial CO2 rebreathing technique under different hemodynamic and ventilation/perfusion matching conditions. Crit Care Med. 2003 Feb; 31(2):543-51.
    View in: PubMed
  33. Musch G, Layfield JD, Harris RS, Melo MF, Winkler T, Callahan RJ, Fischman AJ, Venegas JG. Topographical distribution of pulmonary perfusion and ventilation, assessed by PET in supine and prone humans. J Appl Physiol. 2002 Nov; 93(5):1841-51.
    View in: PubMed
  34. de Abreu MG, Geiger S, Winkler T, Ragaller M, Pfeiffer T, Leutheuser D, Albrecht DM. Evaluation of a new device for noninvasive measurement of nonshunted pulmonary capillary blood flow in patients with acute lung injury. Intensive Care Med. 2002 Mar; 28(3):318-23.
    View in: PubMed
  35. Ragaller M, Bleyl J, Tschö U, Winkler T, Regner M, Rasche S, Koch T, Albrecht M. Effects of inhalation of perfluorocarbon aerosol on oxygenation and pulmonary function compared to PGI2 inhalation in a sheep model of oleic acid-induced lung injury. Intensive Care Med. 2001 May; 27(5):889-97.
    View in: PubMed
  36. Winkler T. Identifikation einer vereinigten Modells für Ventilationsmechanik und Gasaustausch bei maschineller Beatmung. Wagner D, et al. (Eds.) Ausgezeichnete Dissertationen 2000, Lecture Notes in Informatics - Dissertations. 2001; D-1:165-174.
  37. WinklerT. Sample title. Sample journal. 2001; 111:A111.
  38. Winkler T. Ventilationsmechanik und Gasaustausch: Identifikation eines vereinigten Modells bei maschineller Beatmung. 2000.
  39. Winkler T. Identifikation eines vereinigten Modells für Ventilationsmechanik und Gasaustausch bei maschineller Beatmung [Ph.D.]. 2000.
  40. Winkler T, Krause A, Kaiser S. Simulation of mechanical respiration using a multicompartment model for ventilation mechanics and gas exchange. Int J Clin Monit Comput. 1995; 12(4):231-9.
    View in: PubMed
  41. Winkler T. Entwurf und Realisierung eines mathematischen Mehrkompartimentmodells zur Beschreibung der Lungenmechanik, Gasaustausch und Metabolismus intubierter Patienten [diploma]. 1992.
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