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Herbert Benson, M.D.

TitleMind/Body Medical Institute Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMind and Body Medical Institute
824 Boylston Street
Chestnut Hill MA 02467
Phone617/632-9530
Fax866/509-0732

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Alert MD, Rastegar S, Foret M, Slipp L, Jacquart J, Macklin E, Baim M, Fricchione G, Benson H, Denninger J, Yeung A. The effectiveness of a comprehensive mind body weight loss intervention for overweight and obese adults: A pilot study. Complement Ther Med. 2013 Aug; 21(4):286-93.
    View in: PubMed
  2. Bhasin MK, Dusek JA, Chang BH, Joseph MG, Denninger JW, Fricchione GL, Benson H, Libermann TA. Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS One. 2013; 8(5):e62817.
    View in: PubMed
  3. Tilt AC, Werner PD, Brown DF, Alam HB, Warshaw AL, Parry BA, Jazbar B, Booker A, Stangenberg L, Fricchione GL, Benson H, Lillemoe KD, Conrad C. Low degree of formal education and musical experience predict degree of music-induced stress reduction in relatives and friends of patients: a single-center, randomized controlled trial. Ann Surg. 2013 May; 257(5):834-8.
    View in: PubMed
  4. Yeung A, Slipp LE, Jacquart J, Fava M, Denninger JW, Benson H, Fricchione GL. The treatment of depressed chinese americans using qigong in a health care setting: a pilot study. Evid Based Complement Alternat Med. 2013; 2013:168784.
    View in: PubMed
  5. Park ER, Traeger L, Vranceanu AM, Scult M, Lerner JA, Benson H, Denninger J, Fricchione GL. The Development of a Patient-Centered Program Based on the Relaxation Response: The Relaxation Response Resiliency Program (3RP). Psychosomatics. 2013 Mar; 54(2):165-74.
    View in: PubMed
  6. Wang F, Man JK, Lee EK, Wu T, Benson H, Fricchione GL, Wang W, Yeung A. The effects of qigong on anxiety, depression, and psychological well-being: a systematic review and meta-analysis. Evid Based Complement Alternat Med. 2013; 2013:152738.
    View in: PubMed
  7. Yeung A, Lepoutre V, Wayne P, Yeh G, Slipp LE, Fava M, Denninger JW, Benson H, Fricchione GL. Tai chi treatment for depression in Chinese Americans: a pilot study. Am J Phys Med Rehabil. 2012 Oct; 91(10):863-70.
    View in: PubMed
  8. Hoch DB, Watson AJ, Linton DA, Bello HE, Senelly M, Milik MT, Baim MA, Jethwani K, Fricchione GL, Benson H, Kvedar JC. The feasibility and impact of delivering a mind-body intervention in a virtual world. PLoS One. 2012; 7(3):e33843.
    View in: PubMed
  9. Chang BH, Dusek JA, Benson H. Psychobiological changes from relaxation response elicitation: long-term practitioners vs. novices. Psychosomatics. 2011 Nov-Dec; 52(6):550-9.
    View in: PubMed
  10. Vitalo AG, Gorantla S, Fricchione JG, Scichilone JM, Camacho J, Niemi SM, Denninger JW, Benson H, Yarmush ML, Levine JB. Environmental enrichment with nesting material accelerates wound healing in isolation-reared rats. Behav Brain Res. 2012 Jan 15; 226(2):606-12.
    View in: PubMed
  11. Rosenblatt LE, Gorantla S, Torres JA, Yarmush RS, Rao S, Park ER, Denninger JW, Benson H, Fricchione GL, Bernstein B, Levine JB. Relaxation response-based yoga improves functioning in young children with autism: a pilot study. J Altern Complement Med. 2011 Nov; 17(11):1029-35.
    View in: PubMed
  12. Beard C, Stason WB, Wang Q, Manola J, Dean-Clower E, Dusek JA, Decristofaro S, Webster A, Doherty-Gilman AM, Rosenthal DS, Benson H. Effects of complementary therapies on clinical outcomes in patients being treated with radiation therapy for prostate cancer. Cancer. 2011 Jan 1; 117(1):96-102.
    View in: PubMed
  13. Chang BH, Casey A, Dusek JA, Benson H. Relaxation response and spirituality: Pathways to improve psychological outcomes in cardiac rehabilitation. J Psychosom Res. 2010 Aug; 69(2):93-100.
    View in: PubMed
  14. Samuelson M, Foret M, Baim M, Lerner J, Fricchione G, Benson H, Dusek J, Yeung A. Exploring the effectiveness of a comprehensive mind-body intervention for medical symptom relief. J Altern Complement Med. 2010 Feb; 16(2):187-92.
    View in: PubMed
  15. Casey A, Chang BH, Huddleston J, Virani N, Benson H, Dusek JA. A model for integrating a mind/body approach to cardiac rehabilitation: outcomes and correlators. J Cardiopulm Rehabil Prev. 2009 Jul-Aug; 29(4):230-8; quiz 239-40.
    View in: PubMed
  16. Evans KC, Dougherty DD, Schmid AM, Scannell E, McCallister A, Benson H, Dusek JA, Lazar SW. Modulation of spontaneous breathing via limbic/paralimbic-bulbar circuitry: an event-related fMRI study. Neuroimage. 2009 Sep; 47(3):961-71.
    View in: PubMed
  17. Vitalo A, Fricchione J, Casali M, Berdichevsky Y, Hoge EA, Rauch SL, Berthiaume F, Yarmush ML, Benson H, Fricchione GL, Levine JB. Nest making and oxytocin comparably promote wound healing in isolation reared rats. PLoS One. 2009; 4(5):e5523.
    View in: PubMed
  18. Dusek JA, Benson H. Mind-body medicine: a model of the comparative clinical impact of the acute stress and relaxation responses. Minn Med. 2009 May; 92(5):47-50.
    View in: PubMed
  19. Nelson A, Hartl W, Jauch KW, Fricchione GL, Benson H, Warshaw AL, Conrad C. The impact of music on hypermetabolism in critical illness. Curr Opin Clin Nutr Metab Care. 2008 Nov; 11(6):790-4.
    View in: PubMed
  20. Dusek JA, Otu HH, Wohlhueter AL, Bhasin M, Zerbini LF, Joseph MG, Benson H, Libermann TA. Genomic counter-stress changes induced by the relaxation response. PLoS One. 2008; 3(7):e2576.
    View in: PubMed
  21. Dusek JA, Hibberd PL, Buczynski B, Chang BH, Dusek KC, Johnston JM, Wohlhueter AL, Benson H, Zusman RM. Stress management versus lifestyle modification on systolic hypertension and medication elimination: a randomized trial. J Altern Complement Med. 2008 Mar; 14(2):129-38.
    View in: PubMed
  22. Galvin JA, Benson H, Deckro GR, Fricchione GL, Dusek JA. The relaxation response: reducing stress and improving cognition in healthy aging adults. Complement Ther Clin Pract. 2006 Aug; 12(3):186-91.
    View in: PubMed
  23. Benson H, Dusek JA, Sherwood JB, Lam P, Bethea CF, Carpenter W, Levitsky S, Hill PC, Clem DW, Jain MK, Drumel D, Kopecky SL, Mueller PS, Marek D, Rollins S, Hibberd PL. Study of the Therapeutic Effects of Intercessory Prayer (STEP) in cardiac bypass patients: a multicenter randomized trial of uncertainty and certainty of receiving intercessory prayer. Am Heart J. 2006 Apr; 151(4):934-42.
    View in: PubMed
  24. Dusek JA, Chang BH, Zaki J, Lazar S, Deykin A, Stefano GB, Wohlhueter AL, Hibberd PL, Benson H. Association between oxygen consumption and nitric oxide production during the relaxation response. Med Sci Monit. 2006 Jan; 12(1):CR1-10.
    View in: PubMed
  25. Lazar SW, Kerr CE, Wasserman RH, Gray JR, Greve DN, Treadway MT, McGarvey M, Quinn BT, Dusek JA, Benson H, Rauch SL, Moore CI, Fischl B. Meditation experience is associated with increased cortical thickness. Neuroreport. 2005 Nov 28; 16(17):1893-7.
    View in: PubMed
  26. Peng CK, Henry IC, Mietus JE, Hausdorff JM, Khalsa G, Benson H, Goldberger AL. Heart rate dynamics during three forms of meditation. Int J Cardiol. 2004 May; 95(1):19-27.
    View in: PubMed
  27. Stefano GB, Esch T, Cadet P, Zhu W, Mantione K, Benson H. Endocannabinoids as autoregulatory signaling molecules: coupling to nitric oxide and a possible association with the relaxation response. Med Sci Monit. 2003 Apr; 9(4):RA63-75.
    View in: PubMed
  28. Esch T, Stefano GB, Fricchione GL, Benson H. The role of stress in neurodegenerative diseases and mental disorders. Neuro Endocrinol Lett. 2002 Jun; 23(3):199-208.
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  29. Esch T, Stefano GB, Fricchione GL, Benson H. Stress-related diseases -- a potential role for nitric oxide. Med Sci Monit. 2002 Jun; 8(6):RA103-18.
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  30. Deckro GR, Ballinger KM, Hoyt M, Wilcher M, Dusek J, Myers P, Greenberg B, Rosenthal DS, Benson H. The evaluation of a mind/body intervention to reduce psychological distress and perceived stress in college students. J Am Coll Health. 2002 May; 50(6):281-7.
    View in: PubMed
  31. Esch T, Stefano GB, Fricchione GL, Benson H. Stress in cardiovascular diseases. Med Sci Monit. 2002 May; 8(5):RA93-RA101.
    View in: PubMed
  32. Dusek JA, Sherwood JB, Friedman R, Myers P, Bethea CF, Levitsky S, Hill PC, Jain MK, Kopecky SL, Mueller PS, Lam P, Benson H, Hibberd PL. Study of the Therapeutic Effects of Intercessory Prayer (STEP): study design and research methods. Am Heart J. 2002 Apr; 143(4):577-84.
    View in: PubMed
  33. Stefano GB, Fricchione GL, Slingsby BT, Benson H. The placebo effect and relaxation response: neural processes and their coupling to constitutive nitric oxide. Brain Res Brain Res Rev. 2001 Mar; 35(1):1-19.
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  34. Stefano GB, Murga J, Benson H, Zhu W, Bilfinger TV, Magazine HI. Nitric oxide inhibits norepinephrine stimulated contraction of human internal thoracic artery and rat aorta. Pharmacol Res. 2001 Feb; 43(2):199-203.
    View in: PubMed
  35. Nakao M, Myers P, Fricchione G, Zuttermeister PC, Barsky AJ, Benson H. Somatization and symptom reduction through a behavioral medicine intervention in a mind/body medicine clinic. Behav Med. 2001; 26(4):169-76.
    View in: PubMed
  36. Nakao M, Fricchione G, Zuttermeister PC, Myers P, Barsky AJ, Benson H. Effects of gender and marital status on somatic symptoms of patients attending a mind/body medicine clinic. Behav Med. 2001; 26(4):159-68.
    View in: PubMed
  37. Nakao M, Fricchione G, Myers P, Zuttermeister PC, Barsky AJ, Benson H. Depression and education as predicting factors for completion of a behavioral medicine intervention in a mind/body medicine clinic. Behav Med. 2001; 26(4):177-84.
    View in: PubMed
  38. Nakao M, Fricchione G, Myers P, Zuttermeister PC, Baim M, Mandle CL, Medich C, Wells-Federman CL, Martin Arcari P, Ennis M, Barsky AJ, Benson H. Anxiety is a good indicator for somatic symptom reduction through behavioral medicine intervention in a mind/body medicine clinic. Psychother Psychosom. 2001 Jan-Feb; 70(1):50-7.
    View in: PubMed
  39. Tasiemski A, Salzet M, Benson H, Fricchione GL, Bilfinger TV, Goumon Y, Metz-Boutigue MH, Aunis D, Stefano GB. The presence of antibacterial and opioid peptides in human plasma during coronary artery bypass surgery. J Neuroimmunol. 2000 Sep 22; 109(2):228-35.
    View in: PubMed
  40. Lazar SW, Bush G, Gollub RL, Fricchione GL, Khalsa G, Benson H. Functional brain mapping of the relaxation response and meditation. Neuroreport. 2000 May 15; 11(7):1581-5.
    View in: PubMed
  41. Benson H, Dusek JA. Self-reported health, and illness and the use of conventional and unconventional medicine and mind/body healing by Christian Scientists and others. J Nerv Ment Dis. 1999 Sep; 187(9):539-48.
    View in: PubMed
  42. Peng CK, Mietus JE, Liu Y, Khalsa G, Douglas PS, Benson H, Goldberger AL. Exaggerated heart rate oscillations during two meditation techniques. Int J Cardiol. 1999 Jul 31; 70(2):101-7.
    View in: PubMed
  43. Koenig HG, Idler E, Kasl S, Hays JC, George LK, Musick M, Larson DB, Collins TR, Benson H. Religion, spirituality, and medicine: a rebuttal to skeptics. Int J Psychiatry Med. 1999; 29(2):123-31.
    View in: PubMed
  44. Benson H. The nocebo effect: history and physiology. Prev Med. 1997 Sep-Oct; 26(5 Pt 1):612-5.
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  45. MacFarlane BV, Wright A, O'Callaghan J, Benson HA. Chronic neuropathic pain and its control by drugs. Pharmacol Ther. 1997; 75(1):1-19.
    View in: PubMed
  46. Jacobs GD, Benson H, Friedman R. Topographic EEG mapping of the relaxation response. Biofeedback Self Regul. 1996 Jun; 21(2):121-9.
    View in: PubMed
  47. Benson H. Commentary: self-care, the three-legged stool, and remembered wellness. J Cardiovasc Nurs. 1996 Apr; 10(3):1-3.
    View in: PubMed
  48. Jacobs GD, Benson H, Friedman R. Perceived benefits in a behavioral-medicine insomnia program: a clinical report. Am J Med. 1996 Feb; 100(2):212-6.
    View in: PubMed
  49. Benson H, Friedman R. Harnessing the power of the placebo effect and renaming it "remembered wellness". Annu Rev Med. 1996; 47:193-9.
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  50. Mittleman MA, Maclure M, Sherwood JB, Mulry RP, Tofler GH, Jacobs SC, Friedman R, Benson H, Muller JE. Triggering of acute myocardial infarction onset by episodes of anger. Determinants of Myocardial Infarction Onset Study Investigators. Circulation. 1995 Oct 1; 92(7):1720-5.
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  51. Jacobs SC, Friedman R, Parker JD, Tofler GH, Jimenez AH, Muller JE, Benson H, Stone PH. Use of skin conductance changes during mental stress testing as an index of autonomic arousal in cardiovascular research. Am Heart J. 1994 Dec; 128(6 Pt 1):1170-7.
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  52. Jacobs GD, Rosenberg PA, Friedman R, Matheson J, Peavy GM, Domar AD, Benson H. Multifactor behavioral treatment of chronic sleep-onset insomnia using stimulus control and the relaxation response. A preliminary study. Behav Modif. 1993 Oct; 17(4):498-509.
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  53. Domar AD, Zuttermeister PC, Seibel M, Benson H. Psychological improvement in infertile women after behavioral treatment: a replication. Fertil Steril. 1992 Jul; 58(1):144-7.
    View in: PubMed
  54. Myers SS, Benson H. Psychological factors in healing: a new perspective on an old debate. Behav Med. 1992; 18(1):5-11.
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  55. Kass JD, Friedman R, Leserman J, Caudill M, Zuttermeister PC, Benson H. An Inventory of Positive Psychological Attitudes with potential relevance to health outcomes: validation and preliminary testing. Behav Med. 1991; 17(3):121-9.
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  56. Goodale IL, Domar AD, Benson H. Alleviation of premenstrual syndrome symptoms with the relaxation response. Obstet Gynecol. 1990 Apr; 75(4):649-55.
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  57. Mandle CL, Domar AD, Harrington DP, Leserman J, Bozadjian EM, Friedman R, Benson H. Relaxation response in femoral angiography. Radiology. 1990 Mar; 174(3 Pt 1):737-9.
    View in: PubMed
  58. Domar AD, Seibel MM, Benson H. The mind/body program for infertility: a new behavioral treatment approach for women with infertility. Fertil Steril. 1990 Feb; 53(2):246-9.
    View in: PubMed
  59. Hellman CJ, Budd M, Borysenko J, McClelland DC, Benson H. A study of the effectiveness of two group behavioral medicine interventions for patients with psychosomatic complaints. Behav Med. 1990; 16(4):165-73.
    View in: PubMed
  60. Benson H, Malhotra MS, Goldman RF, Jacobs GD, Hopkins PJ. Three case reports of the metabolic and electroencephalographic changes during advanced Buddhist meditation techniques. Behav Med. 1990; 16(2):90-5.
    View in: PubMed
  61. Benson H. Hypnosis and the relaxation response. Gastroenterology. 1989 Jun; 96(6):1609-11.
    View in: PubMed
  62. Leserman J, Stuart EM, Mamish ME, Benson H. The efficacy of the relaxation response in preparing for cardiac surgery. Behav Med. 1989; 15(3):111-7.
    View in: PubMed
  63. Shannon DC, Carley DW, Benson H. Aging of modulation of heart rate. Am J Physiol. 1987 Oct; 253(4 Pt 2):H874-7.
    View in: PubMed
  64. Fentress DW, Masek BJ, Mehegan JE, Benson H. Biofeedback and relaxation-response training in the treatment of pediatric migraine. Dev Med Child Neurol. 1986 Apr; 28(2):139-46.
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  65. Crary B, Hauser SL, Borysenko M, Kutz I, Hoban C, Ault KA, Weiner HL, Benson H. Epinephrine-induced changes in the distribution of lymphocyte subsets in peripheral blood of humans. J Immunol. 1983 Sep; 131(3):1178-81.
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  66. Benson H, Dryer T, Hartley LH. Decreased VO2 consumption during exercise with elicitation of the relaxation response. J Human Stress. 1978 Jun; 4(2):38-42.
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  67. Benson H, Rosner BA, Marzetta BR, Klemchuk HP. Decreased blood pressure in borderline hypertensive subjects who practiced meditation. J Chronic Dis. 1974 Mar; 27(3):163-9.
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  68. Benson H, Rosner BA, Marzetta BR, Klemchuk HM. Decreased blood-pressure in pharmacologically treated hypertensive patients who regularly elicited the relaxation response. Lancet. 1974 Feb 23; 1(7852):289-91.
    View in: PubMed
  69. Kumar R, Wallace WA, Ramirez A, Benson H, Abelmann WH. Hemodynamic effects of pneumonia. II. Expansion of plasma volume. J Clin Invest. 1970 Apr; 49(4):799-805.
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  70. Benson H, Akbarian M, Adler LN, Abelmann WH. Hemodynamic effects of pneumonia. I. Normal and hypodynamic responses. J Clin Invest. 1970 Apr; 49(4):791-8.
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