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Last Name
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David E. Housman, PH.D.

TitleMember of the Faculty of the Harvard-MIT Division of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology
AddressMass Institute of Technology
Cancer Research, E18-521
77 Massachusetts Ave
Cambridge MA 02139
Phone617/253-3013

 Mentoring 
 completed student projects
Establishing a link between PKC and CUGB1 in Myotonic Dystrophy Type I
Summer, 06/20/11 - 08/12/11

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. van Blitterswijk M, Wang ET, Friedman BA, Keagle PJ, Lowe P, Leclerc AL, van den Berg LH, Housman DE, Veldink JH, Landers JE. Characterization of FUS Mutations in Amyotrophic Lateral Sclerosis Using RNA-Seq. PLoS One. 2013; 8(4):e60788.
    View in: PubMed
  2. Tabchy A, Eltonsy N, Housman DE, Mills GB. Systematic identification of combinatorial drivers and targets in cancer cell lines. PLoS One. 2013; 8(4):e60339.
    View in: PubMed
  3. Sontag EM, Joachimiak LA, Tan Z, Tomlinson A, Housman DE, Glabe CG, Potkin SG, Frydman J, Thompson LM. Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):3077-82.
    View in: PubMed
  4. Sathasivam K, Neueder A, Gipson TA, Landles C, Benjamin AC, Bondulich MK, Smith DL, Faull RL, Roos RA, Howland D, Detloff PJ, Housman DE, Bates GP. Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease. Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6):2366-70.
    View in: PubMed
  5. Ng CW, Yildirim F, Yap YS, Dalin S, Matthews BJ, Velez PJ, Labadorf A, Housman DE, Fraenkel E. Extensive changes in DNA methylation are associated with expression of mutant huntingtin. Proc Natl Acad Sci U S A. 2013 Feb 5; 110(6):2354-9.
    View in: PubMed
  6. Wang ET, Cody NA, Jog S, Biancolella M, Wang TT, Treacy DJ, Luo S, Schroth GP, Housman DE, Reddy S, Lécuyer E, Burge CB. Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins. Cell. 2012 Aug 17; 150(4):710-24.
    View in: PubMed
  7. Janas MM, Wang E, Love T, Harris AS, Stevenson K, Semmelmann K, Shaffer JM, Chen PH, Doench JG, Yerramilli SV, Neuberg DS, Iliopoulos D, Housman DE, Burge CB, Novina CD. Reduced expression of ribosomal proteins relieves microRNA-mediated repression. Mol Cell. 2012 Apr 27; 46(2):171-86.
    View in: PubMed
  8. Crook ZR, Housman DE. Dysregulation of dopamine receptor D2 as a sensitive measure for Huntington disease pathology in model mice. Proc Natl Acad Sci U S A. 2012 May 8; 109(19):7487-92.
    View in: PubMed
  9. Parkesh R, Childs-Disney JL, Nakamori M, Kumar A, Wang E, Wang T, Hoskins J, Tran T, Housman D, Thornton CA, Disney MD. Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching. J Am Chem Soc. 2012 Mar 14; 134(10):4731-42.
    View in: PubMed
  10. Jun HJ, Acquaviva J, Chi D, Lessard J, Zhu H, Woolfenden S, Bronson RT, Pfannl R, White F, Housman DE, Iyer L, Whittaker CA, Boskovitz A, Raval A, Charest A. Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme. Oncogene. 2012 Jun 21; 31(25):3039-50.
    View in: PubMed
  11. Acquaviva J, Jun HJ, Lessard J, Ruiz R, Zhu H, Donovan M, Woolfenden S, Boskovitz A, Raval A, Bronson RT, Pfannl R, Whittaker CA, Housman DE, Charest A. Chronic activation of wild-type epidermal growth factor receptor and loss of Cdkn2a cause mouse glioblastoma formation. Cancer Res. 2011 Dec 1; 71(23):7198-206.
    View in: PubMed
  12. Crook ZR, Housman D. Huntington's disease: can mice lead the way to treatment? Neuron. 2011 Feb 10; 69(3):423-35.
    View in: PubMed
  13. Williams AL, Housman DE, Rinard MC, Gifford DK. Rapid haplotype inference for nuclear families. Genome Biol. 2010; 11(10):R108.
    View in: PubMed
  14. Crittenden JR, Dunn DE, Merali FI, Woodman B, Yim M, Borkowska AE, Frosch MP, Bates GP, Housman DE, Lo DC, Graybiel AM. CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease. Hum Mol Genet. 2010 May 1; 19(9):1756-65.
    View in: PubMed
  15. Wooten EC, Iyer LK, Montefusco MC, Hedgepeth AK, Payne DD, Kapur NK, Housman DE, Mendelsohn ME, Huggins GS. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. PLoS One. 2010; 5(1):e8830.
    View in: PubMed
  16. Weiss A, Abramowski D, Bibel M, Bodner R, Chopra V, DiFiglia M, Fox J, Kegel K, Klein C, Grueninger S, Hersch S, Housman D, Régulier E, Rosas HD, Stefani M, Zeitlin S, Bilbe G, Paganetti P. Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease. Anal Biochem. 2009 Dec 1; 395(1):8-15.
    View in: PubMed
  17. Paganetti P, Weiss A, Trapp M, Hammerl I, Bleckmann D, Bodner RA, Coven-Easter S, Housman DE, Parker CN. Development of a method for the high-throughput quantification of cellular proteins. Chembiochem. 2009 Jul 6; 10(10):1678-88.
    View in: PubMed
  18. Brocklebank D, Gayán J, Andresen JM, Roberts SA, Young AB, Snodgrass SR, Penney JB, Ramos-Arroyo MA, Cha JJ, Rosas HD, Hersch SM, Feigin A, Cherny SS, Wexler NS, Housman DE, Cardon LR. Repeat instability in the 27-39 CAG range of the HD gene in the Venezuelan kindreds: Counseling implications. Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5; 150B(3):425-9.
    View in: PubMed
  19. Jun HJ, Woolfenden S, Coven S, Lane K, Bronson R, Housman D, Charest A. Epigenetic regulation of c-ROS receptor tyrosine kinase expression in malignant gliomas. Cancer Res. 2009 Mar 15; 69(6):2180-4.
    View in: PubMed
  20. Peter I, Kelley-Hedgepeth A, Huggins GS, Housman DE, Mendelsohn ME, Vita JA, Vasan RS, Levy D, Benjamin EJ, Mitchell GF. Association between arterial stiffness and variations in oestrogen-related genes. J Hum Hypertens. 2009 Oct; 23(10):636-44.
    View in: PubMed
  21. Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2712-6.
    View in: PubMed
  22. Kelley-Hedgepeth A, Peter I, Montefusco MC, Levy D, Benjamin EJ, Vasan RS, Mendelsohn ME, Housman D, Huggins GS, Mitchell GF. The KCNMB1 E65K variant is associated with reduced central pulse pressure in the community-based Framingham Offspring Cohort. J Hypertens. 2009 Jan; 27(1):55-60.
    View in: PubMed
  23. Parikh RR, Housman D, Yang Q, Toppmeyer D, Wilson LD, Haffty BG. Prognostic value of triple-negative phenotype at the time of locally recurrent, conservatively treated breast cancer. Int J Radiat Oncol Biol Phys. 2008 Nov 15; 72(4):1056-63.
    View in: PubMed
  24. Williams BR, Prabhu VR, Hunter KE, Glazier CM, Whittaker CA, Housman DE, Amon A. Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells. Science. 2008 Oct 31; 322(5902):703-9.
    View in: PubMed
  25. Mills JR, Hippo Y, Robert F, Chen SM, Malina A, Lin CJ, Trojahn U, Wendel HG, Charest A, Bronson RT, Kogan SC, Nadon R, Housman DE, Lowe SW, Pelletier J. mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A. 2008 Aug 5; 105(31):10853-8.
    View in: PubMed
  26. Gayán J, Brocklebank D, Andresen JM, Alkorta-Aranburu G, Zameel Cader M, Roberts SA, Cherny SS, Wexler NS, Cardon LR, Housman DE. Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds. Genet Epidemiol. 2008 Jul; 32(5):445-53.
    View in: PubMed
  27. Fuller CD, Housman DM, Thomas CR. Radiotherapy for thymoma and thymic carcinoma. Hematol Oncol Clin North Am. 2008 Jun; 22(3):489-507.
    View in: PubMed
  28. Peter I, Kelley-Hedgepeth A, Fox CS, Cupples LA, Huggins GS, Housman DE, Karas RH, Mendelsohn ME, Levy D, Murabito JM. Variation in estrogen-related genes associated with cardiovascular phenotypes and circulating estradiol, testosterone, and dehydroepiandrosterone sulfate levels. J Clin Endocrinol Metab. 2008 Jul; 93(7):2779-85.
    View in: PubMed
  29. Kelley-Hedgepeth A, Peter I, Kip K, Montefusco M, Kogan S, Cox D, Ordovas J, Levy D, Reis S, Mendelsohn M, Housman D, Huggins G. The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade. J Hum Hypertens. 2008 Jul; 22(7):512-5.
    View in: PubMed
  30. Chopra V, Fox JH, Lieberman G, Dorsey K, Matson W, Waldmeier P, Housman DE, Kazantsev A, Young AB, Hersch S. A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16685-9.
    View in: PubMed
  31. Bergmeier W, Goerge T, Wang HW, Crittenden JR, Baldwin AC, Cifuni SM, Housman DE, Graybiel AM, Wagner DD. Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III. J Clin Invest. 2007 Jun; 117(6):1699-707.
    View in: PubMed
  32. Coufal M, Maxwell MM, Russel DE, Amore AM, Altmann SM, Hollingsworth ZR, Young AB, Housman DE, Kazantsev AG. Discovery of a novel small-molecule targeting selective clearance of mutant huntingtin fragments. J Biomol Screen. 2007 Apr; 12(3):351-60.
    View in: PubMed
  33. Peter I, Huggins GS, Shearman AM, Pollak A, Schmid CH, Cupples LA, Demissie S, Patten RD, Karas RH, Housman DE, Mendelsohn ME, Vasan RS, Benjamin EJ. Age-related changes in echocardiographic measurements: association with variation in the estrogen receptor-alpha gene. Hypertension. 2007 May; 49(5):1000-6.
    View in: PubMed
  34. Andresen JM, Gayán J, Djoussé L, Roberts S, Brocklebank D, Cherny SS. The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset. Ann Hum Genet. 2007 May; 71(Pt 3):295-301.
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  35. Horiuchi K, Umetani M, Minami T, Okayama H, Takada S, Yamamoto M, Aburatani H, Reid PC, Housman DE, Hamakubo T, Kodama T. Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17278-83.
    View in: PubMed
  36. Andresen JM, Gayán J, Cherny SS, Brocklebank D, Alkorta-Aranburu G, Addis EA, Cardon LR, Housman DE, Wexler NS. Replication of twelve association studies for Huntington's disease residual age of onset in large Venezuelan kindreds. J Med Genet. 2007 Jan; 44(1):44-50.
    View in: PubMed
  37. Charest A, Wilker EW, McLaughlin ME, Lane K, Gowda R, Coven S, McMahon K, Kovach S, Feng Y, Yaffe MB, Jacks T, Housman D. ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice. Cancer Res. 2006 Aug 1; 66(15):7473-81.
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  38. Bodner RA, Housman DE, Kazantsev AG. New directions for neurodegenerative disease therapy: using chemical compounds to boost the formation of mutant protein inclusions. Cell Cycle. 2006 Jul; 5(14):1477-80.
    View in: PubMed
  39. Tabchy A, Housman D. Huntington's disease: A transcriptional report card from the peripheral blood: can it measure disease progression in Huntington's disease? Eur J Hum Genet. 2006 Jun; 14(6):649-50.
    View in: PubMed
  40. Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4246-51.
    View in: PubMed
  41. Shearman AM, Cooper JA, Kotwinski PJ, Miller GJ, Humphries SE, Ardlie KG, Jordan B, Irenze K, Lunetta KL, Schuit SC, Uitterlinden AG, Pols HA, Demissie S, Cupples LA, Mendelsohn ME, Levy D, Housman DE. Estrogen receptor alpha gene variation is associated with risk of myocardial infarction in more than seven thousand men from five cohorts. Circ Res. 2006 Mar 17; 98(5):590-2.
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  42. Peter I, Shearman AM, Zucker DR, Schmid CH, Demissie S, Cupples LA, Larson MG, Vasan RS, D'Agostino RB, Karas RH, Mendelsohn ME, Housman DE, Levy D. Variation in estrogen-related genes and cross-sectional and longitudinal blood pressure in the Framingham Heart Study. J Hypertens. 2005 Dec; 23(12):2193-200.
    View in: PubMed
  43. Peter I, Shearman AM, Vasan RS, Zucker DR, Schmid CH, Demissie S, Cupples LA, Kuvin JT, Karas RH, Mendelsohn ME, Housman DE, Benjamin EJ. Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women. Am J Hypertens. 2005 Nov; 18(11):1388-95.
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  44. Wilson LD, Housman D, Smith BD. Merkel cell carcinoma: improved outcome with the addition of adjuvant therapy. J Clin Oncol. 2005 Oct 1; 23(28):7236-7; author reply 7237-8.
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  45. Shearman AM, Cooper JA, Kotwinski PJ, Humphries SE, Mendelsohn ME, Housman DE, Miller GJ. Estrogen receptor alpha gene variation and the risk of stroke. Stroke. 2005 Oct; 36(10):2281-2.
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  46. Fox CS, Yang Q, Cupples LA, Guo CY, Atwood LD, Murabito JM, Levy D, Mendelsohn ME, Housman DE, Shearman AM. Sex-specific association between estrogen receptor-alpha gene variation and measures of adiposity: the Framingham Heart Study. J Clin Endocrinol Metab. 2005 Nov; 90(11):6257-62.
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  47. Prawitt D, Enklaar T, Gärtner-Rupprecht B, Spangenberg C, Lausch E, Reutzel D, Fees S, Korzon M, Brozek I, Limon J, Housman DE, Pelletier J, Zabel B. Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumor. Nat Genet. 2005 Aug; 37(8):785-6; author reply 786-7.
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  48. Shearman AM, Demissie S, Cupples LA, Peter I, Schmid CH, Ordovas JM, Mendelsohn ME, Housman DE. Tobacco smoking, estrogen receptor alpha gene variation and small low density lipoprotein level. Hum Mol Genet. 2005 Aug 15; 14(16):2405-13.
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  49. Demissie S, Cupples LA, Shearman AM, Gruenthal KM, Peter I, Schmid CH, Karas RH, Housman DE, Mendelsohn ME, Ordovas JM. Estrogen receptor-alpha variants are associated with lipoprotein size distribution and particle levels in women: the Framingham Heart Study. Atherosclerosis. 2006 Mar; 185(1):210-8.
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  50. Yang Q, Lai CQ, Parnell L, Cupples LA, Adiconis X, Zhu Y, Wilson PW, Housman DE, Shearman AM, D'Agostino RB, Ordovas JM. Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study. J Lipid Res. 2005 Jul; 46(7):1416-25.
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  51. Prawitt D, Enklaar T, Gärtner-Rupprecht B, Spangenberg C, Oswald M, Lausch E, Schmidtke P, Reutzel D, Fees S, Lucito R, Korzon M, Brozek I, Limon J, Housman DE, Pelletier J, Zabel B. Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor. Proc Natl Acad Sci U S A. 2005 Mar 15; 102(11):4085-90.
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  52. Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, Kazantsev AG. A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):892-7.
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  53. McCarty JH, Lacy-Hulbert A, Charest A, Bronson RT, Crowley D, Housman D, Savill J, Roes J, Hynes RO. Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 2005 Jan; 132(1):165-76.
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  54. Crittenden JR, Bergmeier W, Zhang Y, Piffath CL, Liang Y, Wagner DD, Housman DE, Graybiel AM. CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med. 2004 Sep; 10(9):982-6.
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  55. Natoli TA, Alberta JA, Bortvin A, Taglienti ME, Menke DB, Loring J, Jaenisch R, Page DC, Housman DE, Kreidberg JA. Wt1 functions in the development of germ cells in addition to somatic cell lineages of the testis. Dev Biol. 2004 Apr 15; 268(2):429-40.
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  56. Wexler NS, Lorimer J, Porter J, Gomez F, Moskowitz C, Shackell E, Marder K, Penchaszadeh G, Roberts SA, Gayán J, Brocklebank D, Cherny SS, Cardon LR, Gray J, Dlouhy SR, Wiktorski S, Hodes ME, Conneally PM, Penney JB, Gusella J, Cha JH, Irizarry M, Rosas D, Hersch S, Hollingsworth Z, MacDonald M, Young AB, Andresen JM, Housman DE, De Young MM, Bonilla E, Stillings T, Negrette A, Snodgrass SR, Martinez-Jaurrieta MD, Ramos-Arroyo MA, Bickham J, Ramos JS, Marshall F, Shoulson I, Rey GJ, Feigin A, Arnheim N, Acevedo-Cruz A, Acosta L, Alvir J, Fischbeck K, Thompson LM, Young A, Dure L, O'Brien CJ, Paulsen J, Brickman A, Krch D, Peery S, Hogarth P, Higgins DS, Landwehrmeyer B. Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset. Proc Natl Acad Sci U S A. 2004 Mar 9; 101(10):3498-503.
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  57. Tian XL, Kadaba R, You SA, Liu M, Timur AA, Yang L, Chen Q, Szafranski P, Rao S, Wu L, Housman DE, DiCorleto PE, Driscoll DJ, Borrow J, Wang Q. Identification of an angiogenic factor that when mutated causes susceptibility to Klippel-Trenaunay syndrome. Nature. 2004 Feb 12; 427(6975):640-5.
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  58. Shearman AM, Karasik D, Gruenthal KM, Demissie S, Cupples LA, Housman DE, Kiel DP. Estrogen receptor beta polymorphisms are associated with bone mass in women and men: the Framingham Study. J Bone Miner Res. 2004 May; 19(5):773-81.
    View in: PubMed
  59. Shearman AM, Cupples LA, Demissie S, Peter I, Schmid CH, Karas RH, Mendelsohn ME, Housman DE, Levy D. Association between estrogen receptor alpha gene variation and cardiovascular disease. JAMA. 2003 Nov 5; 290(17):2263-70.
    View in: PubMed
  60. Mitra RD, Butty VL, Shendure J, Williams BR, Housman DE, Church GM. Digital genotyping and haplotyping with polymerase colonies. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5926-31.
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  61. Charest A, Lane K, McMahon K, Park J, Preisinger E, Conroy H, Housman D. Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21). Genes Chromosomes Cancer. 2003 May; 37(1):58-71.
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  62. Apostol BL, Kazantsev A, Raffioni S, Illes K, Pallos J, Bodai L, Slepko N, Bear JE, Gertler FB, Hersch S, Housman DE, Marsh JL, Thompson LM. A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5950-5.
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  63. Fluiter K, Housman D, Ten Asbroek AL, Baas F. Killing cancer by targeting genes that cancer cells have lost: allele-specific inhibition, a novel approach to the treatment of genetic disorders. Cell Mol Life Sci. 2003 May; 60(5):834-43.
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  64. Osman A, Jordan B, Lessard PA, Muhammad N, Haron MR, Riffin NM, Sinskey AJ, Rha C, Housman DE. Genetic diversity of Eurycoma longifolia inferred from single nucleotide polymorphisms. Plant Physiol. 2003 Mar; 131(3):1294-301.
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  65. Charest A, Kheifets V, Park J, Lane K, McMahon K, Nutt CL, Housman D. Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma. Proc Natl Acad Sci U S A. 2003 Feb 4; 100(3):916-21.
    View in: PubMed
  66. Alberta JA, Springett GM, Rayburn H, Natoli TA, Loring J, Kreidberg JA, Housman D. Role of the WT1 tumor suppressor in murine hematopoiesis. Blood. 2003 Apr 1; 101(7):2570-4.
    View in: PubMed
  67. Natoli TA, McDonald A, Alberta JA, Taglienti ME, Housman DE, Kreidberg JA. A mammal-specific exon of WT1 is not required for development or fertility. Mol Cell Biol. 2002 Jun; 22(12):4433-8.
    View in: PubMed
  68. Dash AB, Williams IR, Kutok JL, Tomasson MH, Anastasiadou E, Lindahl K, Li S, Van Etten RA, Borrow J, Housman D, Druker B, Gilliland DG. A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9. Proc Natl Acad Sci U S A. 2002 May 28; 99(11):7622-7.
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  69. Kazantsev A, Walker HA, Slepko N, Bear JE, Preisinger E, Steffan JS, Zhu YZ, Gertler FB, Housman DE, Marsh JL, Thompson LM. A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nat Genet. 2002 Apr; 30(4):367-76.
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  70. Jordan B, Charest A, Dowd JF, Blumenstiel JP, Yeh Rf RF, Osman A, Housman DE, Landers JE. Genome complexity reduction for SNP genotyping analysis. Proc Natl Acad Sci U S A. 2002 Mar 5; 99(5):2942-7.
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  71. Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, Kurokawa R, Housman DE, Jackson GR, Marsh JL, Thompson LM. Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature. 2001 Oct 18; 413(6857):739-43.
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  72. Toki S, Kawasaki H, Tashiro N, Housman DE, Graybiel AM. Guanine nucleotide exchange factors CalDAG-GEFI and CalDAG-GEFII are colocalized in striatal projection neurons. J Comp Neurol. 2001 Sep 3; 437(4):398-407.
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  73. Guillemette C, De Vivo I, Hankinson SE, Haiman CA, Spiegelman D, Housman DE, Hunter DJ. Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels. Cancer Epidemiol Biomarkers Prev. 2001 Jun; 10(6):711-4.
    View in: PubMed
  74. Charest A, Lane K, McMahon K, Housman DE. Association of a novel PDZ domain-containing peripheral Golgi protein with the Q-SNARE (Q-soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor) protein syntaxin 6. J Biol Chem. 2001 Aug 3; 276(31):29456-65.
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  75. Lecerf JM, Shirley TL, Zhu Q, Kazantsev A, Amersdorfer P, Housman DE, Messer A, Huston JS. Human single-chain Fv intrabodies counteract in situ huntingtin aggregation in cellular models of Huntington's disease. Proc Natl Acad Sci U S A. 2001 Apr 10; 98(8):4764-9.
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  76. Ten Asbroek AL, Olsen J, Housman D, Baas F, Stanton V. Genetic variation in mRNA coding sequences of highly conserved genes. Physiol Genomics. 2001 Apr 2; 5(3):113-8.
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  77. Volkert MR, Elliott NA, Housman DE. Functional genomics reveals a family of eukaryotic oxidation protection genes. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14530-5.
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  78. Pulver AE, Mulle J, Nestadt G, Swartz KL, Blouin JL, Dombroski B, Liang KY, Housman DE, Kazazian HH, Antonarakis SE, Lasseter VK, Wolyniec PS, Thornquist MH, McGrath JA. Genetic heterogeneity in schizophrenia: stratification of genome scan data using co-segregating related phenotypes. Mol Psychiatry. 2000 Nov; 5(6):650-3.
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  79. Guillemette C, Ritter JK, Auyeung DJ, Kessler FK, Housman DE. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene. Pharmacogenetics. 2000 Oct; 10(7):629-44.
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  80. Chattopadhyay S, Kaul R, Charest A, Housman D, Chen J. SMAR1, a novel, alternatively spliced gene product, binds the Scaffold/Matrix-associated region at the T cell receptor beta locus. Genomics. 2000 Aug 15; 68(1):93-6.
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  81. Woolley AT, Guillemette C, Li Cheung C, Housman DE, Lieber CM. Direct haplotyping of kilobase-size DNA using carbon nanotube probes. Nat Biotechnol. 2000 Jul; 18(7):760-3.
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  82. Steffan JS, Kazantsev A, Spasic-Boskovic O, Greenwald M, Zhu YZ, Gohler H, Wanker EE, Bates GP, Housman DE, Thompson LM. The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription. Proc Natl Acad Sci U S A. 2000 Jun 6; 97(12):6763-8.
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  83. Shearman AM, Ordovas JM, Cupples LA, Schaefer EJ, Harmon MD, Shao Y, Keen JD, DeStefano AL, Joost O, Wilson PW, Housman DE, Myers RH. Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: a genome-wide scan in the Framingham study. Hum Mol Genet. 2000 May 22; 9(9):1315-20.
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  84. Guillemette C, Millikan RC, Newman B, Housman DE. Genetic polymorphisms in uridine diphospho-glucuronosyltransferase 1A1 and association with breast cancer among African Americans. Cancer Res. 2000 Feb 15; 60(4):950-6.
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  85. Dzau V, Frank M, Reich M, Austin MJ, Aebersold R, Cowley A, Housman D, Mulligan R, Rosenberg R. Constants and scientific progress. Physiol Genomics. 1999 Nov 11; 1(3):107.
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  86. Kazantsev A, Preisinger E, Dranovsky A, Goldgaber D, Housman D. Insoluble detergent-resistant aggregates form between pathological and nonpathological lengths of polyglutamine in mammalian cells. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11404-9.
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  87. Saba S, Vanderbrink BA, Luciano B, Aronovitz MJ, Berul CI, Reddy S, Housman D, Mendelsohn ME, Estes NA, Wang PJ. Localization of the sites of conduction abnormalities in a mouse model of myotonic dystrophy. J Cardiovasc Electrophysiol. 1999 Sep; 10(9):1214-20.
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  88. Antonarakis SE, Blouin JL, Lasseter VK, Gehrig C, Radhakrishna U, Nestadt G, Housman DE, Kazazian HH, Kalman K, Gutman G, Fantino E, Chandy KG, Gargus JJ, Pulver AE. Lack of linkage or association between schizophrenia and the polymorphic trinucleotide repeat within the KCNN3 gene on chromosome 1q21. Am J Med Genet. 1999 Aug 20; 88(4):348-51.
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  89. Basilion JP, Schievella AR, Burns E, Rioux P, Olson JC, Monia BP, Lemonidis KM, Stanton VP, Housman DE. Selective killing of cancer cells based on loss of heterozygosity and normal variation in the human genome: a new paradigm for anticancer drug therapy. Mol Pharmacol. 1999 Aug; 56(2):359-69.
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  90. Dzau VJ, Austin MJ, Brown P, Cowley A, Housman D, Mulligan R, Rosenberg R. Revolution and renaissance. Physiol Genomics. 1999 Jul 15; 1(1):1-2.
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  91. Preisinger E, Jordan BM, Kazantsev A, Housman D. Evidence for a recruitment and sequestration mechanism in Huntington's disease. Philos Trans R Soc Lond B Biol Sci. 1999 Jun 29; 354(1386):1029-34.
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  92. Hunter K, Greenwood J, Yang YL, Cunningham JM, Birren B, Housman D. An integrated somatic cell hybrid, YAC, and BAC map of the Rmc1 region of mouse chromosome 1. Genomics. 1999 Jun 15; 58(3):318-22.
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  93. Curtis L, Blouin JL, Radhakrishna U, Gehrig C, Lasseter VK, Wolyniec P, Nestadt G, Dombroski B, Kazazian HH, Pulver AE, Housman D, Bertrand D, Antonarakis SE. No evidence for linkage between schizophrenia and markers at chromosome 15q13-14. Am J Med Genet. 1999 Apr 16; 88(2):109-12.
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  94. Zhang X, Tsao H, Tsuji T, Minoshima S, McBride J, Majewski P, Todd R, Shimizu N, Wong DT, Housman DE, Haluska FG. Identification and mutation analysis of DOC-1R, a DOC-1 growth suppressor-related gene. Biochem Biophys Res Commun. 1999 Feb 5; 255(1):59-63.
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  95. Berul CI, Maguire CT, Aronovitz MJ, Greenwood J, Miller C, Gehrmann J, Housman D, Mendelsohn ME, Reddy S. DMPK dosage alterations result in atrioventricular conduction abnormalities in a mouse myotonic dystrophy model. J Clin Invest. 1999 Feb; 103(4):R1-7.
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  96. Ashworth A, Lloyd S, Brown J, Gydesen S, Sorensen SA, Brun A, Englund E, Humphreys C, Housman D, Badura M, Stanton V, Taylor K, Cameron J, Munroe D, Johansson J, Rossor M, Fisher EM, Collinge J. Molecular genetic characterisation of frontotemporal dementia on chromosome 3. Dement Geriatr Cogn Disord. 1999; 10 Suppl 1:93-101.
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  97. Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM. A family of cAMP-binding proteins that directly activate Rap1. Science. 1998 Dec 18; 282(5397):2275-9.
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  98. Ushijima T, Nomoto T, Sugimura T, Housman DE, Nagao M. Isolation of 48 genetic markers appropriate for high throughput genotyping of inbred rat strains by B1 repetitive sequence-representational difference analysis. Mamm Genome. 1998 Dec; 9(12):1008-12.
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  99. Nichols KE, Harkin DP, Levitz S, Krainer M, Kolquist KA, Genovese C, Bernard A, Ferguson M, Zuo L, Snyder E, Buckler AJ, Wise C, Ashley J, Lovett M, Valentine MB, Look AT, Gerald W, Housman DE, Haber DA. Inactivating mutations in an SH2 domain-encoding gene in X-linked lymphoproliferative syndrome. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13765-70.
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  100. Kawasaki H, Springett GM, Toki S, Canales JJ, Harlan P, Blumenstiel JP, Chen EJ, Bany IA, Mochizuki N, Ashbacher A, Matsuda M, Housman DE, Graybiel AM. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci U S A. 1998 Oct 27; 95(22):13278-83.
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  101. Blouin JL, Dombroski BA, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G, Thornquist M, Ullrich G, McGrath J, Kasch L, Lamacz M, Thomas MG, Gehrig C, Radhakrishna U, Snyder SE, Balk KG, Neufeld K, Swartz KL, DeMarchi N, Papadimitriou GN, Dikeos DG, Stefanis CN, Chakravarti A, Childs B, Housman DE, Kazazian HH, Antonarakis S, Pulver AE. Schizophrenia susceptibility loci on chromosomes 13q32 and 8p21. Nat Genet. 1998 Sep; 20(1):70-3.
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  102. Reece M, Prawitt D, Landers J, Kast C, Gros P, Housman D, Zabel BU, Pelletier J. Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules. FEBS Lett. 1998 Aug 21; 433(3):245-50.
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  103. Jing J, Reed J, Huang J, Hu X, Clarke V, Edington J, Housman D, Anantharaman TS, Huff EJ, Mishra B, Porter B, Shenker A, Wolfson E, Hiort C, Kantor R, Aston C, Schwartz DC. Automated high resolution optical mapping using arrayed, fluid-fixed DNA molecules. Proc Natl Acad Sci U S A. 1998 Jul 7; 95(14):8046-51.
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  104. Housman D, Ledley FD. Why pharmacogenomics? Why now? Nat Biotechnol. 1998 Jun; 16(6):492-3.
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  105. Heesen M, Berman MA, Charest A, Housman D, Gerard C, Dorf ME. Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1. Immunogenetics. 1998 Apr; 47(5):364-70.
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  106. Cooper PR, Smilinich NJ, Day CD, Nowak NJ, Reid LH, Pearsall RS, Reece M, Prawitt D, Landers J, Housman DE, Winterpacht A, Zabel BU, Pelletier J, Weissman BE, Shows TB, Higgins MJ. Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain. Genomics. 1998 Apr 1; 49(1):38-51.
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  107. Karayiorgou M, Gogos JA, Galke BL, Wolyniec PS, Nestadt G, Antonarakis SE, Kazazian HH, Housman DE, Pulver AE. Identification of sequence variants and analysis of the role of the catechol-O-methyl-transferase gene in schizophrenia susceptibility. Biol Psychiatry. 1998 Mar 15; 43(6):425-31.
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  108. Das M, Chu LL, Ghahremani M, Abrams-Ogg T, Roy MS, Housman D, Pelletier J. Characterization of an abundant short interspersed nuclear element (SINE) present in Canis familiaris. Mamm Genome. 1998 Jan; 9(1):64-9.
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  109. Rodriguez P, Munroe D, Prawitt D, Chu LL, Bric E, Kim J, Reid LH, Davies C, Nakagama H, Loebbert R, Winterpacht A, Petruzzi MJ, Higgins MJ, Nowak N, Evans G, Shows T, Weissman BE, Zabel B, Housman DE, Pelletier J. Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone. Genomics. 1997 Sep 15; 44(3):253-65.
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  110. Sobulo OM, Borrow J, Tomek R, Reshmi S, Harden A, Schlegelberger B, Housman D, Doggett NA, Rowley JD, Zeleznik-Le NJ. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3). Proc Natl Acad Sci U S A. 1997 Aug 5; 94(16):8732-7.
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  111. Haluska FG, Thiele C, Goldstein A, Tsao H, Benoit EP, Housman D. Lack of phospholipase A2 mutations in neuroblastoma, melanoma and colon-cancer cell lines. Int J Cancer. 1997 Jul 17; 72(2):337-9.
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  112. Davis BM, McCurrach ME, Taneja KL, Singer RH, Housman DE. Expansion of a CUG trinucleotide repeat in the 3' untranslated region of myotonic dystrophy protein kinase transcripts results in nuclear retention of transcripts. Proc Natl Acad Sci U S A. 1997 Jul 8; 94(14):7388-93.
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  113. Reddy PS, Housman DE. The complex pathology of trinucleotide repeats. Curr Opin Cell Biol. 1997 Jun; 9(3):364-72.
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  114. Beckers MC, Ernst E, Diez E, Morissette C, Gervais F, Hunter K, Housman D, Yoshida S, Skamene E, Gros P. High-resolution linkage map of mouse chromosome 13 in the vicinity of the host resistance locus Lgn1. Genomics. 1997 Feb 1; 39(3):254-63.
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  115. Flores JF, Walker GJ, Glendening JM, Haluska FG, Castresana JS, Rubio MP, Pastorfide GC, Boyer LA, Kao WH, Bulyk ML, Barnhill RL, Hayward NK, Housman DE, Fountain JW. Loss of the p16INK4a and p15INK4b genes, as well as neighboring 9p21 markers, in sporadic melanoma. Cancer Res. 1996 Nov 1; 56(21):5023-32.
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  116. Shearman AM, Hudson TJ, Andresen JM, Wu X, Sohn RL, Haluska F, Housman DE, Weiss JS. The gene for schnyder's crystalline corneal dystrophy maps to human chromosome 1p34.1-p36. Hum Mol Genet. 1996 Oct; 5(10):1667-72.
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  117. Mihich E, Housman D. Seventh annual Pezcoller Symposium: cancer genes--functional aspects. Cancer Res. 1996 Sep 15; 56(18):4282-7.
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  118. Borrow J, Stanton VP, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dubé I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet. 1996 Sep; 14(1):33-41.
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  119. Russell MW, Munroe DJ, Bric E, Housman DE, Dietz-Band J, Riethman HC, Collins FS, Brody LC. A 500-kb physical map and contig from the Harvey ras-1 gene to the 11p telomere. Genomics. 1996 Jul 15; 35(2):353-60.
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  120. Reddy S, Smith DB, Rich MM, Leferovich JM, Reilly P, Davis BM, Tran K, Rayburn H, Bronson R, Cros D, Balice-Gordon RJ, Housman D. Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy. Nat Genet. 1996 Jul; 13(3):325-35.
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  121. Dackowski WR, Connors TD, Bowe AE, Stanton V, Housman D, Doggett NA, Landes GM, Klinger KW. The region surrounding the PKD1 gene: a 700-kb P1 contig from a YAC-deficient interval. Genome Res. 1996 Jun; 6(6):515-24.
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  122. Elango R, Riba L, Housman D, Hunter K. Generation and mapping of Mus spretus strain-specific markers for rapid genomic scanning. Mamm Genome. 1996 May; 7(5):340-3.
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  123. Aburatani H, Stanton VP, Housman DE. High-resolution physical mapping by combined Alu-hybridization/PCR screening: construction of a yeast artificial chromosome map covering 31 centimorgans in 3p21-p14. Proc Natl Acad Sci U S A. 1996 Apr 30; 93(9):4474-9.
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  124. Qin S, Nowak NJ, Zhang J, Sait SN, Mayers PG, Higgins MJ, Cheng Y, Li L, Munroe DJ, Gerhard DS, Weber BH, Bric E, Housman DE, Evans GA, Shows TB. A high-resolution physical map of human chromosome 11. Proc Natl Acad Sci U S A. 1996 Apr 2; 93(7):3149-54.
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  125. Hunter KW, Riba L, Schalkwyk L, Clark M, Resenchuk S, Beeghly A, Su J, Tinkov F, Lee P, Ramu E, Lehrach H, Housman D. Toward the construction of integrated physical and genetic maps of the mouse genome using interspersed repetitive sequence PCR (IRS-PCR) genomics. Genome Res. 1996 Apr; 6(4):290-9.
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  126. Manenti G, Gariboldi M, Elango R, Fiorino A, De Gregorio L, Falvella FS, Hunter K, Housman D, Pierotti MA, Dragani TA. Genetic mapping of a pulmonary adenoma resistance (Par1) in mouse. Nat Genet. 1996 Apr; 12(4):455-7.
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  127. Corless CL, Aburatani H, Fletcher JA, Housman DE, Amin MB, Weinberg DS. Papillary renal cell carcinoma: quantitation of chromosomes 7 and 17 by FISH, analysis of chromosome 3p for LOH, and DNA ploidy. Diagn Mol Pathol. 1996 Mar; 5(1):53-64.
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  128. Gill M, Vallada H, Collier D, Sham P, Holmans P, Murray R, McGuffin P, Nanko S, Owen M, Antonarakis S, Housman D, Kazazian H, Nestadt G, Pulver AE, Straub RE, MacLean CJ, Walsh D, Kendler KS, DeLisi L, Polymeropoulos M, Coon H, Byerley W, Lofthouse R, Gershon E, Read CM, et al. A combined analysis of D22S278 marker alleles in affected sib-pairs: support for a susceptibility locus for schizophrenia at chromosome 22q12. Schizophrenia Collaborative Linkage Group (Chromosome 22). Am J Med Genet. 1996 Feb 16; 67(1):40-5.
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  129. Borrow J, Shearman AM, Stanton VP, Becher R, Collins T, Williams AJ, Dubé I, Katz F, Kwong YL, Morris C, Ohyashiki K, Toyama K, Rowley J, Housman DE. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nat Genet. 1996 Feb; 12(2):159-67.
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  130. Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 1996 Jan 4; 379(6560):88-91.
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  131. Karayiorgou M, Gogos JA, Galke BL, Jeffery JA, Nestadt G, Wolyniec PS, Antonarakis SE, Kazazian HH, Housman DE, Driscoll DA, Pulver AE. Genotype and phenotype analysis at the 22q11 schizophrenia susceptibility locus. Cold Spring Harb Symp Quant Biol. 1996; 61:835-43.
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  132. Pulver AE, Wolyniec PS, Housman D, Kazazian HH, Antonarakis SE, Nestadt G, Lasseter VK, McGrath JA, Dombroski B, Karayiorgou M, Ton C, Blouin JL, Kempf L. The Johns Hopkins University Collaborative Schizophrenia Study: an epidemiologic-genetic approach to test the heterogeneity hypothesis and identify schizophrenia susceptibility genes. Cold Spring Harb Symp Quant Biol. 1996; 61:797-814.
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  133. Moffett P, Bruening W, Nakagama H, Bardeesy N, Housman D, Housman DE, Pelletier J. Antagonism of WT1 activity by protein self-association. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):11105-9.
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  134. Dong WF, Xu Y, Hu QL, Munroe D, Minowada J, Housman DE, Minden MD. Molecular characterization of a chromosome translocation breakpoint t(11;14)(p13;q11) from the cell line KOPT-K1. Leukemia. 1995 Nov; 9(11):1812-7.
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  135. Hsu SY, Kubo M, Chun SY, Haluska FG, Housman DE, Hsueh AJ. Wilms' tumor protein WT1 as an ovarian transcription factor: decreases in expression during follicle development and repression of inhibin-alpha gene promoter. Mol Endocrinol. 1995 Oct; 9(10):1356-66.
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  136. Russell MW, Dick M, Campbell RM, Hulse JE, Munroe DJ, Bric E, Housman DE, Collins FS, Brody LC. Localization of Romano-Ward long QT syndrome gene, LQT1, to the interval between tyrosine hydroxylase (TH) and D11S1349. Am J Hum Genet. 1995 Aug; 57(2):503-7.
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  137. Cai W, Aburatani H, Stanton VP, Housman DE, Wang YK, Schwartz DC. Ordered restriction endonuclease maps of yeast artificial chromosomes created by optical mapping on surfaces. Proc Natl Acad Sci U S A. 1995 May 23; 92(11):5164-8.
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  138. Housman D. Gain of glutamines, gain of function? Nat Genet. 1995 May; 10(1):3-4.
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  139. Lasseter VK, Pulver AE, Wolyniec PS, Nestadt G, Meyers D, Karayiorgou M, Housman D, Antonarakis S, Kazazian H, Kasch L, et al. Follow-up report of potential linkage for schizophrenia on chromosome 22q: Part 3. Am J Med Genet. 1995 Apr 24; 60(2):172-3.
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  140. Bird SJ, Housman DE. Conducting and reporting research. Prof Ethics. 1995 Spring-Summer; 4(3-4):127-54.
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  141. Liu J, Stanton VP, Fujiwara TM, Wang JX, Rezonzew R, Crumley MJ, Morgan K, Gros P, Housman D, Schurr E. Large-scale cloning of human chromosome 2-specific yeast artificial chromosomes (YACs) using an interspersed repetitive sequences (IRS)-PCR approach. Genomics. 1995 Mar 20; 26(2):178-91.
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  142. Munroe DJ, Loebbert R, Bric E, Whitton T, Prawitt D, Vu D, Buckler A, Winterpacht A, Zabel B, Housman DE. Systematic screening of an arrayed cDNA library by PCR. Proc Natl Acad Sci U S A. 1995 Mar 14; 92(6):2209-13.
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  143. Nakagama H, Heinrich G, Pelletier J, Housman DE. Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product. Mol Cell Biol. 1995 Mar; 15(3):1489-98.
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  144. Taneja KL, McCurrach M, Schalling M, Housman D, Singer RH. Foci of trinucleotide repeat transcripts in nuclei of myotonic dystrophy cells and tissues. J Cell Biol. 1995 Mar; 128(6):995-1002.
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  145. Housman D. Human DNA polymorphism. N Engl J Med. 1995 Feb 2; 332(5):318-20.
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  146. Polakiewicz RD, Munroe DJ, Sait SN, Tycowski KT, Nowak NJ, Shows TB, Housman DE, Page DC. Mapping of ribosomal protein S3 and internally nested snoRNA U15A gene to human chromosome 11q13.3-q13.5. Genomics. 1995 Jan 20; 25(2):577-80.
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  147. Haluska FG, Housman DE. Recent advances in the molecular genetics of malignant melanoma. Cancer Surv. 1995; 25:277-92.
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  148. Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, Housman DE, Jacks T. p53 status and the efficacy of cancer therapy in vivo. Science. 1994 Nov 4; 266(5186):807-10.
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  149. Pulver AE, Nestadt G, Goldberg R, Shprintzen RJ, Lamacz M, Wolyniec PS, Morrow B, Karayiorgou M, Antonarakis SE, Housman D, et al. Psychotic illness in patients diagnosed with velo-cardio-facial syndrome and their relatives. J Nerv Ment Dis. 1994 Aug; 182(8):476-8.
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  150. Lowe SW, Jacks T, Housman DE, Ruley HE. Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proc Natl Acad Sci U S A. 1994 Mar 15; 91(6):2026-30.
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  151. Pulver AE, Karayiorgou M, Wolyniec PS, Lasseter VK, Kasch L, Nestadt G, Antonarakis S, Housman D, Kazazian HH, Meyers D, et al. Sequential strategy to identify a susceptibility gene for schizophrenia: report of potential linkage on chromosome 22q12-q13.1: Part 1. Am J Med Genet. 1994 Mar 15; 54(1):36-43.
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  152. Pulver AE, Karayiorgou M, Lasseter VK, Wolyniec P, Kasch L, Antonarakis S, Housman D, Kazazian HH, Meyers D, Nestadt G, et al. Follow-up of a report of a potential linkage for schizophrenia on chromosome 22q12-q13.1: Part 2. Am J Med Genet. 1994 Mar 15; 54(1):44-50.
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  153. Munroe DJ, Haas M, Bric E, Whitton T, Aburatani H, Hunter K, Ward D, Housman DE. IRE-bubble PCR: a rapid method for efficient and representative amplification of human genomic DNA sequences from complex sources. Genomics. 1994 Feb; 19(3):506-14.
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  154. Coleman A, Fountain JW, Nobori T, Olopade OI, Robertson G, Housman DE, Lugo TG. Distinct deletions of chromosome 9p associated with melanoma versus glioma, lung cancer, and leukemia. Cancer Res. 1994 Jan 15; 54(2):344-8.
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  155. Glaser T, Ton CC, Mueller R, Petzl-Erler ML, Oliver C, Nevin NC, Housman DE, Maas RL. Absence of PAX6 gene mutations in Gillespie syndrome (partial aniridia, cerebellar ataxia, and mental retardation). Genomics. 1994 Jan 1; 19(1):145-8.
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  156. Lowe SW, Bodis S, Bardeesy N, McClatchey A, Remington L, Ruley HE, Fisher DE, Jacks T, Pelletier J, Housman DE. Apoptosis and the prognostic significance of p53 mutation. Cold Spring Harb Symp Quant Biol. 1994; 59:419-26.
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  157. Moir DT, Dorman TE, Xue F, Ma NS, Stanton VP, Housman D, Bowden DW, Noll WW, Mao J. Rapid identification of overlapping YACs in the MEN2 region of human chromosome 10 by hybridization with Alu element-mediated PCR products. Gene. 1993 Dec 22; 136(1-2):177-83.
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  158. Hunter KW, Watson ML, Rochelle J, Ontiveros S, Munroe D, Seldin MF, Housman DE. Single-strand conformational polymorphism (SSCP) mapping of the mouse genome: integration of the SSCP, microsatellite, and gene maps of mouse chromosome 1. Genomics. 1993 Dec; 18(3):510-9.
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  159. Church DM, Banks LT, Rogers AC, Graw SL, Housman DE, Gusella JF, Buckler AJ. Identification of human chromosome 9 specific genes using exon amplification. Hum Mol Genet. 1993 Nov; 2(11):1915-20.
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  160. Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 1993 Sep 24; 74(6):957-67.
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  161. Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, Jaenisch R. WT-1 is required for early kidney development. Cell. 1993 Aug 27; 74(4):679-91.
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  162. Petty EM, Gibson LH, Fountain JW, Bolognia JL, Yang-Feng TL, Housman DE, Bale AE. Molecular definition of a chromosome 9p21 germ-line deletion in a woman with multiple melanomas and a plexiform neurofibroma: implications for 9p tumor-suppressor gene(s). Am J Hum Genet. 1993 Jul; 53(1):96-104.
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  163. Schalling M, Hudson TJ, Buetow KH, Housman DE. Direct detection of novel expanded trinucleotide repeats in the human genome. Nat Genet. 1993 Jun; 4(2):135-9.
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  164. Fountain JW, Hudson TJ, Engelstein M, Housman DE, Dracopoli NC. Dinucleotide repeat polymorphism at the D9S126 locus (9p21). Hum Mol Genet. 1993 Jun; 2(6):823.
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  165. Duyao MP, Taylor SA, Buckler AJ, Ambrose CM, Lin C, Groot N, Church D, Barnes G, Wasmuth JJ, Housman DE, et al. A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins. Hum Mol Genet. 1993 Jun; 2(6):673-6.
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  166. Galson DL, Hensold JO, Bishop TR, Schalling M, D'Andrea AD, Jones C, Auron PE, Housman DE. Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis. Mol Cell Biol. 1993 May; 13(5):2929-41.
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  167. Bruhn SL, Housman DE, Lippard SJ. Isolation and characterization of cDNA clones encoding the Drosophila homolog of the HMG-box SSRP family that recognizes specific DNA structures. Nucleic Acids Res. 1993 Apr 11; 21(7):1643-6.
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  168. Haas M, Aburatani H, Stanton VP, Bhatt M, Housman D, Ward DC. Isolation and FISH mapping of 80 cosmid clones on the short arm of human chromosome 3. Genomics. 1993 Apr; 16(1):90-6.
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  169. Andersen LB, Fountain JW, Gutmann DH, Tarlé SA, Glover TW, Dracopoli NC, Housman DE, Collins FS. Mutations in the neurofibromatosis 1 gene in sporadic malignant melanoma cell lines. Nat Genet. 1993 Feb; 3(2):118-21.
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  170. Bruening W, Gros P, Sato T, Stanimir J, Nakamura Y, Housman D, Pelletier J. Analysis of the 11p13 Wilms' tumor suppressor gene (WT1) in ovarian tumors. Cancer Invest. 1993; 11(4):393-9.
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  171. Hinds HL, Ashley CT, Sutcliffe JS, Nelson DL, Warren ST, Housman DE, Schalling M. Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome. Nat Genet. 1993 Jan; 3(1):36-43.
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  172. Baird PN, Groves N, Haber DA, Housman DE, Cowell JK. Identification of mutations in the WT1 gene in tumours from patients with the WAGR syndrome. Oncogene. 1992 Nov; 7(11):2141-9.
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  173. Buschman E, Arceci RJ, Croop JM, Che M, Arias IM, Housman DE, Gros P. mdr2 encodes P-glycoprotein expressed in the bile canalicular membrane as determined by isoform-specific antibodies. J Biol Chem. 1992 Sep 5; 267(25):18093-9.
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  174. Call KM, Ito CY, Lindberg C, Memisoglu A, Petrou C, Glaser T, Jones C, Housman DE. Mapping and characterization of 129 cosmids on human chromosome 11p. Somat Cell Mol Genet. 1992 Sep; 18(5):463-75.
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  175. Fountain JW, Karayiorgou M, Taruscio D, Graw SL, Buckler AJ, Ward DC, Dracopoli NC, Housman DE. Genetic and physical map of the interferon region on chromosome 9p. Genomics. 1992 Sep; 14(1):105-12.
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  176. Hudson TJ, Engelstein M, Lee MK, Ho EC, Rubenfield MJ, Adams CP, Housman DE, Dracopoli NC. Isolation and chromosomal assignment of 100 highly informative human simple sequence repeat polymorphisms. Genomics. 1992 Jul; 13(3):622-9.
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  177. Rubin C, Rubenstein JL, Stechler G, Heeren T, Halton A, Housman D, Kasten L. Depressive affect in "normal" adolescents: relationship to life stress, family, and friends. Am J Orthopsychiatry. 1992 Jul; 62(3):430-41.
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  178. Haber DA, Timmers HT, Pelletier J, Sharp PA, Housman DE. A dominant mutation in the Wilms tumor gene WT1 cooperates with the viral oncogene E1A in transformation of primary kidney cells. Proc Natl Acad Sci U S A. 1992 Jul 1; 89(13):6010-4.
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  179. Valentijn LJ, Bolhuis PA, Zorn I, Hoogendijk JE, van den Bosch N, Hensels GW, Stanton VP, Housman DE, Fischbeck KH, Ross DA, et al. The peripheral myelin gene PMP-22/GAS-3 is duplicated in Charcot-Marie-Tooth disease type 1A. Nat Genet. 1992 Jun; 1(3):166-70.
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  180. Bruening W, Bardeesy N, Silverman BL, Cohn RA, Machin GA, Aronson AJ, Housman D, Pelletier J. Germline intronic and exonic mutations in the Wilms' tumour gene (WT1) affecting urogenital development. Nat Genet. 1992 May; 1(2):144-8.
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  181. Graw SL, Buckler AJ, Britt DE, Jackson CL, Taruscio D, Baldini A, Ward DC, Housman DE. Generation and characterization of a human chromosome 9 cosmid library. Somat Cell Mol Genet. 1992 May; 18(3):269-84.
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  182. Jackson CL, Britt DE, Graw SL, Potts A, Santoro K, Buckler AJ, Housman DE, Mark HF. Construction and characterization of radiation hybrids for chromosome 9, and their use in mapping cosmid probes on the chromosome. Somat Cell Mol Genet. 1992 May; 18(3):285-301.
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  183. Krolewski AS, Krolewski B, Gray M, Stanton V, Warram JH, Housman D. High-frequency DNA sequence polymorphisms in the insulin receptor gene detected by denaturing gradient gel blots. Genomics. 1992 Apr; 12(4):705-9.
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  184. Hubert R, Stanton VP, Aburatani H, Warren J, Li H, Housman DE, Arnheim N. Sperm typing allows accurate measurement of the recombination fraction between D3S2 and D3S3 on the short arm of human chromosome 3. Genomics. 1992 Apr; 12(4):683-7.
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  185. Bruhn SL, Pil PM, Essigmann JM, Housman DE, Lippard SJ. Isolation and characterization of human cDNA clones encoding a high mobility group box protein that recognizes structural distortions to DNA caused by binding of the anticancer agent cisplatin. Proc Natl Acad Sci U S A. 1992 Mar 15; 89(6):2307-11.
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  186. Harley HG, Brook JD, Rundle SA, Crow S, Reardon W, Buckler AJ, Harper PS, Housman DE, Shaw DJ. Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy. Nature. 1992 Feb 6; 355(6360):545-6.
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  187. Boyle AL, Feltquite DM, Dracopoli NC, Housman DE, Ward DC. Rapid physical mapping of cloned DNA on banded mouse chromosomes by fluorescence in situ hybridization. Genomics. 1992 Jan; 12(1):106-15.
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  188. Oettinger MA, Stanger B, Schatz DG, Glaser T, Call K, Housman D, Baltimore D. The recombination activating genes, RAG 1 and RAG 2, are on chromosome 11p in humans and chromosome 2p in mice. Immunogenetics. 1992; 35(2):97-101.
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  189. Graw SL, Schalling M, Housman D, Callen DF, Klinger K, Landes G, Lerner T. Isolation and characterization of a candidate gene for autosomal-dominant polycystic kidney disease. Contrib Nephrol. 1992; 97:110-7.
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  190. Haber DA, Housman DE. Role of the WT1 gene in Wilms' tumour. Cancer Surv. 1992; 12:105-17.
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  191. Haber DA, Housman DE. The genetics of Wilms' tumor. Adv Cancer Res. 1992; 59:41-68.
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  192. Strobel SA, Doucette-Stamm LA, Riba L, Housman DE, Dervan PB. Site-specific cleavage of human chromosome 4 mediated by triple-helix formation. Science. 1991 Dec 13; 254(5038):1639-42.
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  193. Thompson LM, Plummer S, Schalling M, Altherr MR, Gusella JF, Housman DE, Wasmuth JJ. A gene encoding a fibroblast growth factor receptor isolated from the Huntington disease gene region of human chromosome 4. Genomics. 1991 Dec; 11(4):1133-42.
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  194. Samulski RJ, Zhu X, Xiao X, Brook JD, Housman DE, Epstein N, Hunter LA. Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J. 1991 Dec; 10(12):3941-50.
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  195. Haber DA, Sohn RL, Buckler AJ, Pelletier J, Call KM, Housman DE. Alternative splicing and genomic structure of the Wilms tumor gene WT1. Proc Natl Acad Sci U S A. 1991 Nov 1; 88(21):9618-22.
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  196. Pelletier J, Bruening W, Li FP, Haber DA, Glaser T, Housman DE. WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour. Nature. 1991 Oct 3; 353(6343):431-4.
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  197. Doucette-Stamm LA, Riba L, Handelin B, Difilippantonio M, Ward DC, Wasmuth JJ, Gusella JF, Housman DE. Generation and characterization of irradiation hybrids of human chromosome 4. Somat Cell Mol Genet. 1991 Sep; 17(5):471-80.
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  198. Pelletier J, Schalling M, Buckler AJ, Rogers A, Haber DA, Housman D. Expression of the Wilms' tumor gene WT1 in the murine urogenital system. Genes Dev. 1991 Aug; 5(8):1345-56.
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  199. Pelletier J, Brook JD, Housman DE. Assignment of two of the translation initiation factor-4E (EIF4EL1 and EIF4EL2) genes to human chromosomes 4 and 20. Genomics. 1991 Aug; 10(4):1079-82.
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  200. Schwartz CE, Haber DA, Stanton VP, Strong LC, Skolnick MH, Housman DE. Familial predisposition to Wilms tumor does not segregate with the WT1 gene. Genomics. 1991 Aug; 10(4):927-30.
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  201. Goradia TM, Stanton VP, Cui XF, Aburatani H, Li HH, Lange K, Housman DE, Arnheim N. Ordering three DNA polymorphisms on human chromosome 3 by sperm typing. Genomics. 1991 Jul; 10(3):748-55.
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  202. Davis LM, Zabel B, Senger G, Lüdecke HJ, Metzroth B, Call K, Housman D, Claussen U, Horsthemke B, Shows TB. A tumor chromosome rearrangement further defines the 11p13 Wilms tumor locus. Genomics. 1991 Jul; 10(3):588-92.
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  203. Fountain JW, Dracopoli NC, Housman DE, Baldwin AS. MspI RFLP detected by a ZNF-40 cDNA sequence. Nucleic Acids Res. 1991 May 11; 19(9):2514.
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  204. Ton CC, Huff V, Call KM, Cohn S, Strong LC, Housman DE, Saunders GF. Smallest region of overlap in Wilms tumor deletions uniquely implicates an 11p13 zinc finger gene as the disease locus. Genomics. 1991 May; 10(1):293-7.
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  205. Huff V, Miwa H, Haber DA, Call KM, Housman D, Strong LC, Saunders GF. Evidence for WT1 as a Wilms tumor (WT) gene: intragenic germinal deletion in bilateral WT. Am J Hum Genet. 1991 May; 48(5):997-1003.
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  206. Buckler AJ, Chang DD, Graw SL, Brook JD, Haber DA, Sharp PA, Housman DE. Exon amplification: a strategy to isolate mammalian genes based on RNA splicing. Proc Natl Acad Sci U S A. 1991 May 1; 88(9):4005-9.
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  207. Cowell JK, Wadey RB, Haber DA, Call KM, Housman DE, Pritchard J. Structural rearrangements of the WT1 gene in Wilms' tumour cells. Oncogene. 1991 Apr; 6(4):595-9.
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  208. Hensold JO, Dubyak G, Housman DE. Calcium ionophore, A23187, induces commitment to differentiation but inhibits the subsequent expression of erythroid genes in murine erythroleukemia cells. Blood. 1991 Mar 15; 77(6):1362-70.
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  209. Buckler AJ, Pelletier J, Haber DA, Glaser T, Housman DE. Isolation, characterization, and expression of the murine Wilms' tumor gene (WT1) during kidney development. Mol Cell Biol. 1991 Mar; 11(3):1707-12.
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  210. Geissler EN, Liao M, Brook JD, Martin FH, Zsebo KM, Housman DE, Galli SJ. Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter. Somat Cell Mol Genet. 1991 Mar; 17(2):207-14.
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  211. Hunter K, Housman D, Hopkins N. Isolation and characterization of irradiation fusion hybrids from mouse chromosome 1 for mapping Rmc-1, a gene encoding a cellular receptor for MCF class murine retroviruses. Somat Cell Mol Genet. 1991 Mar; 17(2):169-83.
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  212. Royer-Pokora B, Ragg S, Heckl-Ostreicher B, Held M, Loos U, Call K, Glaser T, Housman D, Saunders G, Zabel B, et al. Direct pulsed field gel electrophoresis of Wilms' tumors shows that DNA deletions in 11p13 are rare. Genes Chromosomes Cancer. 1991 Mar; 3(2):89-100.
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  213. Haber DA, Housman DE. Rate-limiting steps: the genetics of pediatric cancers. Cell. 1991 Jan 11; 64(1):5-8.
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  214. Wexler NS, Rose EA, Housman DE. Molecular approaches to hereditary diseases of the nervous system: Huntington's disease as a paradigm. Annu Rev Neurosci. 1991; 14:503-29.
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  215. Tam SY, Geissler EN, Graw SL, Housman DE. Functional expression of the genomic DNA sequences encoding mouse Na,K-ATPase alpha 1 gene by cotransfection of overlapping genomic DNA segments. Mol Cell Biol. 1990 Dec; 10(12):6619-23.
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  216. Glaser T, Lane J, Housman D. A mouse model of the aniridia-Wilms tumor deletion syndrome. Science. 1990 Nov 9; 250(4982):823-7.
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  217. Baas F, Jongsma AP, Broxterman HJ, Arceci RJ, Housman D, Scheffer GL, Riethorst A, van Groenigen M, Nieuwint AW, Joenje H. Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line. Cancer Res. 1990 Sep 1; 50(17):5392-8.
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  218. Pritchard-Jones K, Fleming S, Davidson D, Bickmore W, Porteous D, Gosden C, Bard J, Buckler A, Pelletier J, Housman D, et al. The candidate Wilms' tumour gene is involved in genitourinary development. Nature. 1990 Jul 12; 346(6280):194-7.
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  219. Haber DA, Buckler AJ, Glaser T, Call KM, Pelletier J, Sohn RL, Douglass EC, Housman DE. An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor. Cell. 1990 Jun 29; 61(7):1257-69.
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  220. Raymond M, Rose E, Housman DE, Gros P. Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells. Mol Cell Biol. 1990 Apr; 10(4):1642-51.
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  221. Hensold JO, Hunt CR, Calderwood SK, Housman DE, Kingston RE. DNA binding of heat shock factor to the heat shock element is insufficient for transcriptional activation in murine erythroleukemia cells. Mol Cell Biol. 1990 Apr; 10(4):1600-8.
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  222. Wilson SD, Billings PR, D'Eustachio P, Fournier RE, Geissler E, Lalley PA, Burd PR, Housman DE, Taylor BA, Dorf ME. Clustering of cytokine genes on mouse chromosome 11. J Exp Med. 1990 Apr 1; 171(4):1301-14.
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  223. Arceci RJ, Baas F, Raponi R, Horwitz SB, Housman D, Croop JM. Multidrug resistance gene expression is controlled by steroid hormones in the secretory epithelium of the uterus. Mol Reprod Dev. 1990 Feb; 25(2):101-9.
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  224. Warburton D, Gersen S, Yu MT, Jackson C, Handelin B, Housman D. Monochromosomal rodent-human hybrids from microcell fusion of human lymphoblastoid cells containing an inserted dominant selectable marker. Genomics. 1990 Feb; 6(2):358-66.
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  225. Lichter P, Tang CJ, Call K, Hermanson G, Evans GA, Housman D, Ward DC. High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Science. 1990 Jan 5; 247(4938):64-9.
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  226. Brilliant MH, Szabo G, Katarova Z, Kozak CA, Glaser TM, Greenspan RJ, Housman DE. Sequences homologous to glutamic acid decarboxylase cDNA are present on mouse chromosomes 2 and 10. Genomics. 1990 Jan; 6(1):115-22.
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  227. Fountain JW, Bale SJ, Housman DE, Dracopoli NC. Genetics of melanoma. Cancer Surv. 1990; 9(4):645-71.
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  228. Glaser T, Rose E, Morse H, Housman D, Jones C. A panel of irradiation-reduced hybrids selectively retaining human chromosome 11p13: their structure and use to purify the WAGR gene complex. Genomics. 1990 Jan; 6(1):48-64.
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  229. Haber DA, Housman DE. MspI/HpaII polymorphism in the human multidrug resistance gene 1. Nucleic Acids Res. 1989 Dec 11; 17(23):10142.
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  230. Glaser T, Driscoll DJ, Antonarakis S, Valle D, Housman D. A highly polymorphic locus cloned from the breakpoint of a chromosome 11p13 deletion associated with the WAGR syndrome. Genomics. 1989 Nov; 5(4):880-93.
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  231. Glaser T, Housman D, Lewis WH, Gerhard D, Jones C. A fine-structure deletion map of human chromosome 11p: analysis of J1 series hybrids. Somat Cell Mol Genet. 1989 Nov; 15(6):477-501.
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  232. Glaser T, Matthews KE, Hudson JW, Seth P, Housman DE, Crerar MM. Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively. Genomics. 1989 Oct; 5(3):510-21.
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  233. Emanuel JR, Graw S, Housman D, Levenson R. Identification of a region within the Na,K-ATPase alpha subunit that contributes to differential ouabain sensitivity. Mol Cell Biol. 1989 Sep; 9(9):3744-9.
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  234. Dracopoli NC, Harnett P, Bale SJ, Stanger BZ, Tucker MA, Housman DE, Kefford RF. Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4614-8.
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  235. Bale SJ, Dracopoli NC, Tucker MA, Clark WH, Fraser MC, Stanger BZ, Green P, Donis-Keller H, Housman DE, Greene MH. Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p. N Engl J Med. 1989 May 25; 320(21):1367-72.
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  236. Fong CT, Dracopoli NC, White PS, Merrill PT, Griffith RC, Housman DE, Brodeur GM. Loss of heterozygosity for the short arm of chromosome 1 in human neuroblastomas: correlation with N-myc amplification. Proc Natl Acad Sci U S A. 1989 May; 86(10):3753-7.
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  237. Croop JM, Raymond M, Haber D, Devault A, Arceci RJ, Gros P, Housman DE. The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol. 1989 Mar; 9(3):1346-50.
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  238. Geissler EN, Cheng SV, Gusella JF, Housman DE. Genetic analysis of the dominant white-spotting (W) region on mouse chromosome 5: identification of cloned DNA markers near W. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9635-9.
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  239. Darby JK, Willems PJ, Nakashima P, Johnsen J, Ferrell RE, Wijsman EM, Gerhard DS, Dracopoli NC, Housman D, Henke J, et al. Restriction analysis of the structural alpha-L-fucosidase gene and its linkage to fucosidosis. Am J Hum Genet. 1988 Nov; 43(5):749-55.
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  240. Geissler EN, Ryan MA, Housman DE. The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell. 1988 Oct 7; 55(1):185-92.
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  241. Guild BC, Finer MH, Housman DE, Mulligan RC. Development of retrovirus vectors useful for expressing genes in cultured murine embryonal cells and hematopoietic cells in vivo. J Virol. 1988 Oct; 62(10):3795-801.
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  242. Dracopoli NC, Stanger BZ, Ito CY, Call KM, Lincoln SE, Lander ES, Housman DE. A genetic linkage map of 27 loci from PND to FY on the short arm of human chromosome I. Am J Hum Genet. 1988 Oct; 43(4):462-70.
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  243. Dracopoli NC, Rose E, Whitfield GK, Guidon PT, Bale SJ, Chance PA, Kourides IA, Housman DE. Two thyroid hormone regulated genes, the beta-subunits of nerve growth factor (NGFB) and thyroid stimulating hormone (TSHB), are located less than 310 kb apart in both human and mouse genomes. Genomics. 1988 Aug; 3(2):161-7.
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  244. Dracopoli NC, Stanger BZ, Lager M, Housman DE. Localization of the FGR protooncogene on the genetic linkage map of human chromosome 1p. Genomics. 1988 Aug; 3(2):124-8.
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  245. Kabnick KS, Housman DE. Determinants that contribute to cytoplasmic stability of human c-fos and beta-globin mRNAs are located at several sites in each mRNA. Mol Cell Biol. 1988 Aug; 8(8):3244-50.
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  246. Gros P, Raymond M, Bell J, Housman D. Cloning and characterization of a second member of the mouse mdr gene family. Mol Cell Biol. 1988 Jul; 8(7):2770-8.
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  247. Emanuel JR, Schulz J, Zhou XM, Kent RB, Housman D, Cantley L, Levenson R. Expression of an ouabain-resistant Na,K-ATPase in CV-1 cells after transfection with a cDNA encoding the rat Na,K-ATPase alpha 1 subunit. J Biol Chem. 1988 Jun 5; 263(16):7726-33.
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  248. Arceci RJ, Croop JM, Horwitz SB, Housman D. The gene encoding multidrug resistance is induced and expressed at high levels during pregnancy in the secretory epithelium of the uterus. Proc Natl Acad Sci U S A. 1988 Jun; 85(12):4350-4.
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  249. Croop JM, Gros P, Housman DE. Genetics of multidrug resistance. J Clin Invest. 1988 May; 81(5):1303-9.
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  250. Hensold JO, Housman DE. Decreased expression of the stress protein HSP70 is an early event in murine erythroleukemic cell differentiation. Mol Cell Biol. 1988 May; 8(5):2219-23.
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  251. Hensold JO, Swerdlow PS, Housman DE. A transient increase in histone H2A ubiquitination is coincident with the onset of erythroleukemic cell differentiation. Blood. 1988 Apr; 71(4):1153-6.
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  252. Guild BC, Mulligan RC, Gros P, Housman DE. Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection. Proc Natl Acad Sci U S A. 1988 Mar; 85(5):1595-9.
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  253. von Melchner H, Housman DE. The expression of neomycin phosphotransferase in human promyelocytic leukemia cells (HL60) delays their differentiation. Oncogene. 1988 Feb; 2(2):137-40.
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  254. Kent RB, Fallows DA, Emanuel JR, Lalley PA, Levenson R, Housman DE. Application of gene transfer and gene mapping techniques to functional analysis of the Na,K-ATPase. Prog Clin Biol Res. 1988; 268B:97-104.
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  255. Galson DL, Housman DE. Detection of two tissue-specific DNA-binding proteins with affinity for sites in the mouse beta-globin intervening sequence 2. Mol Cell Biol. 1988 Jan; 8(1):381-92.
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  256. Croop JM, Guild BC, Gros P, Housman DE. Genetics of multidrug resistance: relationship of a cloned gene to the complete multidrug resistant phenotype. Cancer Res. 1987 Nov 15; 47(22):5982-8.
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  257. Kent RB, Emanuel JR, Ben Neriah Y, Levenson R, Housman DE. Ouabain resistance conferred by expression of the cDNA for a murine Na+, K+-ATPase alpha subunit. Science. 1987 Aug 21; 237(4817):901-3.
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  258. Lugo TG, Handelin B, Killary AM, Housman DE, Fournier RE. Isolation of microcell hybrid clones containing retroviral vector insertions into specific human chromosomes. Mol Cell Biol. 1987 Aug; 7(8):2814-20.
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  259. Fallows D, Kent RB, Nelson DL, Emanuel JR, Levenson R, Housman DE. Chromosome-mediated transfer of the murine Na,K-ATPase alpha subunit confers ouabain resistance. Mol Cell Biol. 1987 Aug; 7(8):2985-7.
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  260. Arriza JL, Weinberger C, Cerelli G, Glaser TM, Handelin BL, Housman DE, Evans RM. Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science. 1987 Jul 17; 237(4812):268-75.
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  261. Gerhard DS, Jones C, Morse HG, Handelin B, Weeks V, Housman D. Analysis of human chromosome 11 by somatic cell genetics: reexamination of derivatives of human-hamster cell line J1. Somat Cell Mol Genet. 1987 Jul; 13(4):293-304.
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  262. Housman D. Insertion of dominant selectable markers into the human genome. Somat Cell Mol Genet. 1987 Jul; 13(4):441-6.
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  263. Egeland JA, Gerhard DS, Pauls DL, Sussex JN, Kidd KK, Allen CR, Hostetter AM, Housman DE. Bipolar affective disorders linked to DNA markers on chromosome 11. Nature. 1987 Feb 26-Mar 4; 325(6107):783-7.
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  264. Gerhard DS, Dracopoli NC, Bale SJ, Houghton AN, Watkins P, Payne CE, Greene MH, Housman DE. Evidence against Ha-ras-1 involvement in sporadic and familial melanoma. Nature. 1987 Jan 1-7; 325(6099):73-5.
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  265. Gros P, Croop J, Housman D. Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell. 1986 Nov 7; 47(3):371-80.
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  266. Gros P, Fallows DA, Croop JM, Housman DE. Chromosome-mediated gene transfer of multidrug resistance. Mol Cell Biol. 1986 Nov; 6(11):3785-90.
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  267. Gros P, Ben Neriah YB, Croop JM, Housman DE. Isolation and expression of a complementary DNA that confers multidrug resistance. Nature. 1986 Oct 23-29; 323(6090):728-31.
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  268. Roninson IB, Chin JE, Choi KG, Gros P, Housman DE, Fojo A, Shen DW, Gottesman MM, Pastan I. Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4538-42.
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  269. Weis JH, Seidman JG, Housman DE, Nelson DL. Eucaryotic chromosome transfer: production of a murine-specific cosmid library from a neor-linked fragment of murine chromosome 17. Mol Cell Biol. 1986 Feb; 6(2):441-51.
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  270. Gros P, Croop J, Roninson I, Varshavsky A, Housman DE. Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A. 1986 Jan; 83(2):337-41.
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  271. Housman DE, Glaser T, Gerhard DS, Jones C, Bruns GA, Lewis WH. Mapping of human chromosome 11: organization of genes within the Wilms' tumor region of the chromosome. Cold Spring Harb Symp Quant Biol. 1986; 51 Pt 2:837-41.
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  272. van den Elsen P, Bruns G, Gerhard DS, Pravtcheva D, Jones C, Housman D, Ruddle FA, Orkin S, Terhorst C. Assignment of the gene coding for the T3-delta subunit of the T3-T-cell receptor complex to the long arm of human chromosome 11 and to mouse chromosome 9. Proc Natl Acad Sci U S A. 1985 May; 82(9):2920-4.
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  273. de Martinville B, Kunkel LM, Bruns G, Morlé F, Koenig M, Mandel JL, Horwich A, Latt SA, Gusella JF, Housman D, et al. Localization of DNA sequences in region Xp21 of the human X chromosome: search for molecular markers close to the Duchenne muscular dystrophy locus. Am J Hum Genet. 1985 Mar; 37(2):235-49.
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  274. Wexler NS, Conneally PM, Housman D, Gusella JF. A DNA polymorphism for Huntington's disease marks the future. Arch Neurol. 1985 Jan; 42(1):20-4.
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  275. Gerhard DS, Kidd KK, Kidd JR, Egeland JA, Housman DE. Identification of a recent recombination event within the human beta-globin gene cluster. Proc Natl Acad Sci U S A. 1984 Dec; 81(24):7875-9.
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  276. Minden MD, Gusella JF, Housman D. Chromosome-mediated transfer of the malignant phenotype by human acute myelogenous leukemic cells. Blood. 1984 Oct; 64(4):842-6.
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  277. Weis JH, Nelson DL, Przyborski MJ, Chaplin DD, Mulligan RC, Housman DE, Seidman JG. Eukaryotic chromosome transfer: linkage of the murine major histocompatibility complex to an inserted dominant selectable marker. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4879-83.
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  278. Roninson IB, Abelson HT, Housman DE, Howell N, Varshavsky A. Amplification of specific DNA sequences correlates with multi-drug resistance in Chinese hamster cells. Nature. 1984 Jun 14-20; 309(5969):626-8.
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  279. Levenson R, Racaniello V, Albritton L, Housman D. Molecular cloning of the mouse ouabain-resistance gene. Proc Natl Acad Sci U S A. 1984 Mar; 81(5):1489-93.
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  280. Nelson DL, Weis JH, Przyborski MJ, Mulligan RC, Seidman JG, Housman DE. Metaphase chromosome transfer of introduced selectable markers. J Mol Appl Genet. 1984; 2(6):563-77.
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  281. Tsiftsoglou AS, Wong W, Housman DE. Dexamethasone-sensitive and -insensitive responses during in vitro differentiation of Friend erythroleukemia cells. Biochim Biophys Acta. 1983 Sep 13; 759(3):160-9.
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  282. Housman D, Gusella JF. Application of recombinant DNA techniques to neurogenetic disorders. Res Publ Assoc Res Nerv Ment Dis. 1983; 60:167-72.
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  283. Gusella JF, Jones C, Kao FT, Housman D, Puck TT. Genetic fine-structure mapping in human chromosome 11 by use of repetitive DNA sequences. Proc Natl Acad Sci U S A. 1982 Dec; 79(24):7804-8.
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  284. Gusella JF, Tsiftsoglou AS, Volloch V, Weil SC, Neumann J, Housman DE. Dissociation of hemoglobin accumulation and commitment during murine erythroleukemia cell differentiation by treatment with imidazole. J Cell Physiol. 1982 Oct; 113(1):179-85.
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  285. Volloch V, Housman D. Terminal differentiation of murine erythroleukemia cells: physical stabilization of end-stage cells. J Cell Biol. 1982 May; 93(2):390-4.
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  286. Smith RL, Macara IG, Levenson R, Housman D, Cantley L. Evidence that a Na+/Ca2+ antiport system regulates murine erythroleukemia cell differentiation. J Biol Chem. 1982 Jan 25; 257(2):773-80.
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  287. Tsiftsoglou AS, Wong W, Volloch V, Gusella J, Housman D. Commitment of murine erythroleukemia (MEL) cells to terminal differentiation is associated with coordinated expression of globin and ribosomal genes. Prog Clin Biol Res. 1982; 102 pt A:69-79.
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  288. Levenson R, Housman D. Erasure of the memory response in MEL cells. Dev Biol. 1981 Aug; 86(1):81-6.
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  289. Volloch V, Housman D. Stability of globin mRNA in terminally differentiating murine erythroleukemia cells. Cell. 1981 Feb; 23(2):509-14.
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  290. Gusella JF, Weil SC, Tsiftsoglou AS, Volloch V, Neumann JR, Keys C, Housman DE. Hemin does not cause commitment of murine erythroleukemia (MEL) cells to terminal differentiation. Blood. 1980 Sep; 56(3):481-7.
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  291. Gusella JF, Keys C, VarsanyiBreiner A, Kao FT, Jones C, Puck TT, Housman D. Isolation and localization of DNA segments from specific human chromosomes. Proc Natl Acad Sci U S A. 1980 May; 77(5):2829-33.
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  292. Housman D, Levenson R, Volloch V, Tsiftsoglou A, Gusella J, Parker D, Kernen J, Mitrani A, Weeks V, Witte O, Besmer P. Control of proliferation and differentiation in cells transformed by Friend virus. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 2,:1177-85.
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  293. Levenson R, Kernen J, Mitrani A, Housman D. DNA synthesis is not required for the commitment of murine erythroleukemia cells. Dev Biol. 1980 Jan; 74(1):224-30.
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  294. Levenson R, Kernen J, Housman D. Synchronization of MEL cell commitment with cordycepin. Cell. 1979 Dec; 18(4):1073-8.
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  295. Varsanyi-Breiner A, Gusella JF, Keys C, Housman DE, Sullivan D, Brisson N, Verma DP. The organization of a nuclear DNA sequence from a higher plant: molecular cloning and characterization of soybean ribosomal DNA. Gene. 1979 Nov; 7(3-4):317-34.
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  296. Gusella J, Varsanyi-Breiner A, Kao FT, Jones C, Puck TT, Keys C, Orkin S, Housman D. Precise localization of human beta-globin gene complex on chromosome 11. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):5239-42.
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  297. Clarke BJ, Nathan DG, Alter BP, Forget BG, Hillman DG, Housman D. Hemoglobin synthesis in human BFU-E and CFU-E-derived erythroid colonies. Blood. 1979 Oct; 54(4):805-17.
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  298. Tsiftsoglou AS, Gusella JF, Volloch V, Housman DE. Inhibition by dexamethasone of commitment to erythroid differentiation in murine erythroleukemia cells. Cancer Res. 1979 Oct; 39(10):3849-55.
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  299. Nathan DG, Clarke BJ, Hillman DG, Alter BP, Housman DE. Erythroid precursors in congenital hypoplastic (Diamond-Blackfan) anemia. J Clin Invest. 1978 Feb; 61(2):489-98.
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  300. Clarke BJ, Axelrad AA, Housman D. Friend spleen focus-forming virus production in vitro by a nonerythroid cell line. J Natl Cancer Inst. 1976 Oct; 57(4):853-9.
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  301. Gusella J, Geller R, Clarke B, Weeks V, Housman D. Commitment to erythroid differentiation by friend erythroleukemia cells: a stochastic analysis. Cell. 1976 Oct; 9(2):221-9.
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  302. Gusella JF, Housman D. Induction of erythroid differentiation in vitro by purines and purine analogues. Cell. 1976 Jun; 8(2):263-9.
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  303. Forget BG, Glass J, Housman D. Erythroid cell differentiation. Hamatol Bluttransfus. 1976; 19:109-24.
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  304. Preisler HS, Housman D, Scher W, Friend C. Effects of 5-bromo-2' -deoxyuridine on production of globin messenger RNA in dimethyl sulfoxide-stimulated Friend leukemia cells. Proc Natl Acad Sci U S A. 1973 Oct; 70(10):2956-9.
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