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Orfeu Marcello Buxton, Ph.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Sleep Medicine, BLI-438
221 Longwood Ave
Boston MA 02115
Phone617/525-7118
Fax617/507-9177
Other Positions
TitleAssistant Professor in the Dept. of Social and Behavioral Sciences
InstitutionHarvard School of Public Health
DepartmentDept of Social and Behavioral Sciences


 Biography 
 awards and honors
2010 - Certificate of Distinction in Teaching
2011 - Certificate of Distinction in Teaching

 Overview 
 overview
Dr. Buxton's research examines the causes and health consequences of sleep deficiency. Successful aging is a central focus of this work. Ongoing interdisciplinary human studies involve sleep loss, aging, insomnia, and cardiometabolic risk, as well as health disparities.

Dr. Buxton is a member of the Work, Family, and Health Network and the Harvard site led by Professor Lisa Berkman, Director of the Harvard University Pop Center. Completed and upcoming studies use objective measures of health including assays of dried blood spots and ambulatory sleep assessments to characterize health in large samples, and the efficacy of randomized, multi-site, workplace interventions. Dr. Buxton leads the Biomarker and Sleep Core for the Work, Family and Health Study. Dr. Buxton also serves as an Investigator and on the Internal Advisory Board of the Harvard School of Public Health Center for Work, Health, and Well-being .

After earning a B.S. in Behavioral Neuroscience from the University of Pittsburgh and a stint as a small business owner, Dr. Buxton earned a doctoral degree in Neuroscience from Northwestern University, Evanston, Illinois, working with Professors Eve Van Cauter and Fred Turek. He obtained post-doctoral training in sleep and endocrinology with Dr. Van Cauter at the University of Chicago.

Dr. Buxton co-founded the National Postdoctoral Association, a member-driven organization that provides a unique, national voice for postdoctoral scholars. In the Harvard Division of Sleep Medicine, Dr. Buxton serves as Chair of the Education Committee.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sandoval LF, Huang K, O'Neill JL, Gustafson CJ, Hix E, Harrison J, Clark A, Buxton OM, Feldman SR. Measure of atopic dermatitis disease severity using actigraphy. J Cutan Med Surg. 2014; 18:49-55.
    View in: PubMed
  2. Marino M, Li Y, Rueschman MN, Winkelman JW, Ellenbogen JM, Solet JM, Dulin H, Berkman LF, Buxton OM. Measuring sleep: accuracy, sensitivity, and specificity of wrist actigraphy compared to polysomnography. Sleep. 2013; 36(11):1747-55.
    View in: PubMed
  3. Kingsbury JH, Buxton OM, Emmons KM. Sleep and its Relationship to Racial and Ethnic Disparities in Cardiovascular Disease. Curr Cardiovasc Risk Rep. 2013 Oct; 7(5).
    View in: PubMed
  4. Winkelman JW, Plante DT, Schoerning L, Benson K, Buxton OM, O'Connor SP, Jensen JE, Renshaw PF, Gonenc A. Increased Rostral Anterior Cingulate Cortex Volume in Chronic Primary Insomnia. Sleep. 2013; 36(7):991-998.
    View in: PubMed
  5. Grandner MA, Buxton OM, Jackson N, Sands-Lincoln M, Pandey A, Jean-Louis G. Extreme sleep durations and increased C-reactive protein: effects of sex and ethnoracial group. Sleep. 2013; 36(5):769-79.
    View in: PubMed
  6. Harper DG, Plante DT, Jensen JE, Ravichandran C, Buxton OM, Benson KL, O'Connor SP, Renshaw PF, Winkelman JW. Energetic and cell membrane metabolic products in patients with primary insomnia: a 31-phosphorus magnetic resonance spectroscopy study at 4 tesla. Sleep. 2013; 36(4):493-500.
    View in: PubMed
  7. Buxton OM, Klein LC, Whinnery J, Williams S, McDade T. J.G. Grzywacz and E. Demerouti (Eds.), New frontiers in work and family research. Biomarkers in Work and Family Research. 2013; 170-190.
  8. Reid KJ, Zee PC, Buxton OM. Kryger MH (ed). Atlas of Clinical Sleep Medicine. Circadian Rhythms regulation. 2013.
  9. Fuller PM, Zee PC, Buxton OM. Kryger MH (ed). Atlas of Clinical Sleep Medicine. Sleep Mechanisms. 2013.
  10. Buxton OM, Broussard JL, Zahl AK, Hall M. Redline S, Berger NA (eds) Energy Balance and Cancer Volume 8: Impact of Sleep and Sleep Disturbances on Obesity and Cancer. Effects of sleep deficiency on hormones, cytokines, and metabolism. 2013; 8.
  11. Buxton OM, Okechukwu CA. Authors' response. J Occup Environ Med. 2012 Nov; 54(11):1322-3.
    View in: PubMed
  12. Kim SS, Okechukwu CA, Buxton OM, Dennerlein JT, Boden LI, Hashimoto DM, Sorensen G. Association between work-family conflict and musculoskeletal pain among hospital patient care workers. Am J Ind Med. 2013 Apr; 56(4):488-95.
    View in: PubMed
  13. Buxton OM, Ellenbogen JM, Wang W, Carballeira A, O'Connor S, Cooper D, Gordhandas AJ, McKinney SM, Solet JM. Sleep disruption due to hospital noises: a prospective evaluation. Ann Intern Med. 2012 Aug 7; 157(3):170-9.
    View in: PubMed
  14. Buxton OM, Hopcia K, Sembajwe G, Porter JH, Dennerlein JT, Kenwood C, Stoddard AM, Hashimoto D, Sorensen G. Relationship of sleep deficiency to perceived pain and functional limitations in hospital patient care workers. J Occup Environ Med. 2012 Jul; 54(7):851-8.
    View in: PubMed
  15. Buxton OM, Cain SW, O'Connor SP, Porter JH, Duffy JF, Wang W, Czeisler CA, Shea SA. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med. 2012 Apr 11; 4(129):129ra43.
    View in: PubMed
  16. Hurtado DA, Sabbath EL, Ertel KA, Buxton OM, Berkman LF. Racial disparities in job strain among American and immigrant long-term care workers. Int Nurs Rev. 2012 Jun; 59(2):237-44.
    View in: PubMed
  17. Sorensen G, Stoddard AM, Stoffel S, Buxton O, Sembajwe G, Hashimoto D, Dennerlein JT, Hopcia K. The role of the work context in multiple wellness outcomes for hospital patient care workers. J Occup Environ Med. 2011 Aug; 53(8):899-910.
    View in: PubMed
  18. Ertel KA, Berkman LF, Buxton OM. Socioeconomic status, occupational characteristics, and sleep duration in African/Caribbean immigrants and US White health care workers. Sleep. 2011 Apr; 34(4):509-18.
    View in: PubMed
  19. McKinney SM, Dang-Vu TT, Buxton OM, Solet JM, Ellenbogen JM. Covert waking brain activity reveals instantaneous sleep depth. PLoS One. 2011; 6(3):e17351.
    View in: PubMed
  20. Dang-Vu TT, McKinney SM, Buxton OM, Solet JM, Ellenbogen JM. Spontaneous brain rhythms predict sleep stability in the face of noise. Curr Biol. 2010 Aug 10; 20(15):R626-7.
    View in: PubMed
  21. Berkman LF, Buxton O, Ertel K, Okechukwu C. Managers' practices related to work-family balance predict employee cardiovascular risk and sleep duration in extended care settings. J Occup Health Psychol. 2010 Jul; 15(3):316-29.
    View in: PubMed
  22. Buxton OM, Pavlova M, Reid EW, Wang W, Simonson DC, Adler GK. Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes. 2010 Sep; 59(9):2126-33.
    View in: PubMed
  23. Buxton OM, Marcelli E. Short and long sleep are positively associated with obesity, diabetes, hypertension, and cardiovascular disease among adults in the United States. Soc Sci Med. 2010 Sep; 71(5):1027-36.
    View in: PubMed
  24. Winkelman JW, Benson KL, Buxton OM, Lyoo IK, Yoon S, O'Connor S, Renshaw PF. Lack of hippocampal volume differences in primary insomnia and good sleeper controls: an MRI volumetric study at 3 Tesla. Sleep Med. 2010 Jun; 11(6):576-82.
    View in: PubMed
  25. Omisade A, Buxton OM, Rusak B. Impact of acute sleep restriction on cortisol and leptin levels in young women. Physiol Behav. 2010 Apr 19; 99(5):651-6.
    View in: PubMed
  26. Reid KJ, Zee PC, Buxton O. In Kryger MH (ed). Atlas of Clinical Sleep Medicine. Chapter 3.2 Circadian Rhythms regulation. 2010; 25-27.
  27. Fuller PM, Zee PC, Buxton O. In Kryger MH (ed). Atlas of Clinical Sleep Medicine. Chapter 3.1 Sleep Mechanisms. 2010; 20-25.
  28. Czeisler, CA, Buxton, OM. Principles and Practices of Sleep Medicine. M Kryger, T Roth, W Dement eds. The human circadian timing system and sleep-wake regulation. 2010; 402-19.
  29. Buxton OM, Quintiliani LM, Yang MH, Ebbeling CB, Stoddard AM, Pereira LK, Sorensen G. Association of sleep adequacy with more healthful food choices and positive workplace experiences among motor freight workers. Am J Public Health. 2009 Nov; 99 Suppl 3:S636-43.
    View in: PubMed
  30. Buxton OM, Malarick K, Wang W, Seeman T. Changes in dried blood spot Hb A1c with varied postcollection conditions. Clin Chem. 2009 May; 55(5):1034-6.
    View in: PubMed
  31. Marcelli, Enrico, Louisa Holmes, Magalis Troncoso, Phillip Granberry and Orfeu Buxton. (In)Visible (Im)Migrants:The Health and Socioeconomic Integration of Brazilians in Metropolitan Boston. 2009.
  32. Marcelli, Enrico, Louisa Holmes, Magalis Troncoso, Phillip Granberry and Orfeu Buxton . Permanently Temporary? The Health and Socioeconomic Status of Dominicans in Metropolitan Boston. 2009.
  33. Winkelman JW, Buxton OM, Jensen JE, Benson KL, O'Connor SP, Wang W, Renshaw PF. Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS). Sleep. 2008 Nov; 31(11):1499-506.
    View in: PubMed
  34. Czeisler, CA. OM Buxton, and SB Khalsa. In, Principles and Practices of Sleep Medicine. M Kryger, T Roth, W Dement (eds). The human circadian timing system and sleep-wake regulation. 2005.
  35. Buxton OM, Lee CW, L'Hermite-Baleriaux M, Turek FW, Van Cauter E. Exercise elicits phase shifts and acute alterations of melatonin that vary with circadian phase. Am J Physiol Regul Integr Comp Physiol. 2003 Mar; 284(3):R714-24.
    View in: PubMed
  36. Shawn D. Youngstedt, Orfeu M. Buxton. Amer J Sports Med. Jet Lag and Athletic Performance. 2003; 5:219-226.
  37. Cunningham JM, Buxton OM, Weiss RE. Circadian variation in Cushing's disease and pseudo-Cushing states by analysis of F and ACTH pulsatility. J Endocrinol Invest. 2002 Oct; 25(9):791-9.
    View in: PubMed
  38. Orfeu M. Buxton, Karine Spiegel, and Eve Van Cauter. In: T. Lee-Chiong, M. Carskadon, M. Sateia, vol. eds., Sleep Medicine. Modulation of endocrine function and metabolism by sleep and sleep loss. 2002; 59-69.
  39. Buxton OM, Copinschi G, Van Onderbergen A, Karrison TG, Van Cauter E. A benzodiazepine hypnotic facilitates adaptation of circadian rhythms and sleep-wake homeostasis to an eight hour delay shift simulating westward jet lag. Sleep. 2000 Nov 1; 23(7):915-27.
    View in: PubMed
  40. Horton TH, Buxton OM, Losee-Olson S, Turek FW. Twenty-four-hour profiles of serum leptin in siberian and golden hamsters: photoperiodic and diurnal variations. Horm Behav. 2000 Jun; 37(4):388-98.
    View in: PubMed
  41. Valentinuzzi VS, Buxton OM, Chang AM, Scarbrough K, Ferrari EA, Takahashi JS, Turek FW. Locomotor response to an open field during C57BL/6J active and inactive phases: differences dependent on conditions of illumination. Physiol Behav. 2000 May; 69(3):269-75.
    View in: PubMed
  42. Buxton OM, L'Hermite-Balériaux M, Turek FW, van Cauter E. Daytime naps in darkness phase shift the human circadian rhythms of melatonin and thyrotropin secretion. Am J Physiol Regul Integr Comp Physiol. 2000 Feb; 278(2):R373-82.
    View in: PubMed
  43. Naylor E, Buxton OM, Bergmann BM, Easton A, Zee PC, Turek FW. Effects of aging on sleep in the golden hamster. Sleep. 1998 Nov 1; 21(7):687-93.
    View in: PubMed
  44. Scheen AJ, Buxton OM, Jison M, Van Reeth O, Leproult R, L'Hermite-Baleriaux M, Van Cauter E. Effects of exercise on neuroendocrine secretions and glucose regulation at different times of day. Am J Physiol. 1998 Jun; 274(6 Pt 1):E1040-9.
    View in: PubMed
  45. Buxton OM, L'Hermite-Balériaux M, Hirschfeld U, Cauter E. Acute and delayed effects of exercise on human melatonin secretion. J Biol Rhythms. 1997 Dec; 12(6):568-74.
    View in: PubMed
  46. Leproult R, Copinschi G, Buxton O, Van Cauter E. Sleep loss results in an elevation of cortisol levels the next evening. Sleep. 1997 Oct; 20(10):865-70.
    View in: PubMed
  47. Recio J, Míguez JM, Buxton OM, Challet E. Synchronizing circadian rhythms in early infancy. Med Hypotheses. 1997 Sep; 49(3):229-34.
    View in: PubMed
  48. Buxton OM, Frank SA, L'Hermite-Balériaux M, Leproult R, Turek FW, Van Cauter E. Roles of intensity and duration of nocturnal exercise in causing phase delays of human circadian rhythms. Am J Physiol. 1997 Sep; 273(3 Pt 1):E536-42.
    View in: PubMed
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