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Daniel L. Hartl

TitleProfessor in the Department of Immunology and Infectious Diseases
InstitutionHarvard School of Public Health
DepartmentImmunology and Infectious Diseases
AddressHarvard, FAS Org. and Evol. Biology
Biological Laboratories Room 2119
16 Divinity Ave
Cambridge MA 02138
Phone6174963917

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lemos B, Branco AT, Jiang PP, Hartl DL, Meiklejohn CD. Genome-wide gene expression effects of sex chromosome imprinting in Drosophila. G3 (Bethesda). 2014; 4(1):1-10.
    View in: PubMed
  2. Lukens AK, Ross LS, Heidebrecht R, Javier Gamo F, Lafuente-Monasterio MJ, Booker ML, Hartl DL, Wiegand RC, Wirth DF. Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):799-804.
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  3. Chang HH, Moss EL, Park DJ, Ndiaye D, Mboup S, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL. Malaria life cycle intensifies both natural selection and random genetic drift. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20129-34.
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  4. Corbett-Detig RB, Zhou J, Clark AG, Hartl DL, Ayroles JF. Genetic incompatibilities are widespread within species. Nature. 2013 Dec 5; 504(7478):135-7.
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  5. Yang S, Li J, Zhang X, Zhang Q, Huang J, Chen JQ, Hartl DL, Tian D. Rapidly evolving R genes in diverse grass species confer resistance to rice blast disease. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18572-7.
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  6. Jiang PP, Corbett-Detig RB, Hartl DL, Lozovsky ER. Accessible Mutational Trajectories for the Evolution of Pyrimethamine Resistance in the Malaria Parasite Plasmodium vivax. J Mol Evol. 2013 Sep; 77(3):81-91.
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  7. Meiklejohn CD, Coolon JD, Hartl DL, Wittkopp PJ. The roles of cis- and trans-regulation in the evolution of regulatory incompatibilities and sexually dimorphic gene expression. Genome Res. 2014 Jan; 24(1):84-95.
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  8. Rohe M, Hartl D, Fjorback AN, Klose J, Willnow TE. SORLA-Mediated Trafficking of TrkB Enhances the Response of Neurons to BDNF. PLoS One. 2013; 8(8):e72164.
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  9. Nakagawa S, Gisselbrecht SS, Rogers JM, Hartl DL, Bulyk ML. DNA-binding specificity changes in the evolution of forkhead transcription factors. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12349-54.
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  10. Hartl D, Klatt S, Roch M, Konthur Z, Klose J, Willnow TE, Rohe M. Soluble Alpha-APP (sAPPalpha) Regulates CDK5 Expression and Activity in Neurons. PLoS One. 2013; 8(6):e65920.
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  11. Branco AT, Hartl DL, Lemos B. Chromatin-Associated Proteins HP1 and Mod(mdg4) Modify Y-Linked Regulatory Variation in the Drosophila Testis. Genetics. 2013 Jul; 194(3):609-18.
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  12. Daniels R, Chang HH, Séne PD, Park DC, Neafsey DE, Schaffner SF, Hamilton EJ, Lukens AK, Van Tyne D, Mboup S, Sabeti PC, Ndiaye D, Wirth DF, Hartl DL, Volkman SK. Genetic Surveillance Detects Both Clonal and Epidemic Transmission of Malaria following Enhanced Intervention in Senegal. PLoS One. 2013; 8(4):e60780.
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  13. Carlo AS, Gustafsen C, Mastrobuoni G, Nielsen MS, Burgert T, Hartl D, Rohe M, Nykjaer A, Herz J, Heeren J, Kempa S, Petersen CM, Willnow TE. The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-ß Peptide in the Brain. J Neurosci. 2013 Jan 2; 33(1):358-70.
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  14. Sackton TB, Hartl DL. Meta-Analysis Reveals that Genes Regulated by the Y Chromosome in Drosophila melanogaster Are Preferentially Localized to Repressive Chromatin. Genome Biol Evol. 2013 Jan; 5(1):255-66.
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  15. Corbett-Detig RB, Hartl DL. Population Genomics of Inversion Polymorphisms in Drosophila melanogaster. PLoS Genet. 2012 Dec; 8(12):e1003056.
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  16. Park DJ, Lukens AK, Neafsey DE, Schaffner SF, Chang HH, Valim C, Ribacke U, Van Tyne D, Galinsky K, Galligan M, Becker JS, Ndiaye D, Mboup S, Wiegand RC, Hartl DL, Sabeti PC, Wirth DF, Volkman SK. Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci U S A. 2012 Aug 7; 109(32):13052-7.
    View in: PubMed
  17. Ponce R, Martinsen L, Vicente LM, Hartl DL. Novel genes from formation to function. Int J Evol Biol. 2012; 2012:821645.
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  18. Chang HH, Park DJ, Galinsky KJ, Schaffner SF, Ndiaye D, Ndir O, Mboup S, Wiegand RC, Volkman SK, Sabeti PC, Wirth DF, Neafsey DE, Hartl DL. Genomic Sequencing of Plasmodium falciparum Malaria Parasites from Senegal Reveals the Demographic History of the Population. Mol Biol Evol. 2012 Nov; 29(11):3427-39.
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  19. Zhou J, Sackton TB, Martinsen L, Lemos B, Eickbush TH, Hartl DL. Y chromosome mediates ribosomal DNA silencing and modulates the chromatin state in Drosophila. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9941-6.
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  20. Yeh SD, Do T, Chan C, Cordova A, Carranza F, Yamamoto EA, Abbassi M, Gandasetiawan KA, Librado P, Damia E, Dimitri P, Rozas J, Hartl DL, Roote J, Ranz JM. Functional evidence that a recently evolved Drosophila sperm-specific gene boosts sperm competition. Proc Natl Acad Sci U S A. 2012 Feb 7; 109(6):2043-8.
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  21. Carneiro MO, Taubes CH, Hartl DL. Model transcriptional networks with continuously varying expression levels. BMC Evol Biol. 2011; 11:363.
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  22. Toprak E, Veres A, Michel JB, Chait R, Hartl DL, Kishony R. Evolutionary paths to antibiotic resistance under dynamically sustained drug selection. Nat Genet. 2012 Jan; 44(1):101-5.
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  23. Volkman SK, Ndiaye D, Diakite M, Koita OA, Nwakanma D, Daniels RF, Park DJ, Neafsey DE, Muskavitch MA, Krogstad DJ, Sabeti PC, Hartl DL, Wirth DF. Application of genomics to field investigations of malaria by the international centers of excellence for malaria research. Acta Trop. 2012 Mar; 121(3):324-32.
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  24. Hartl DL. James F. Crow and the art of teaching and mentoring. Genetics. 2011 Dec; 189(4):1129-33.
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  25. Sackton TB, Montenegro H, Hartl DL, Lemos B. Interspecific Y chromosome introgressions disrupt testis-specific gene expression and male reproductive phenotypes in Drosophila. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17046-51.
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  26. Costanzo MS, Hartl DL. The evolutionary landscape of antifolate resistance in Plasmodium falciparum. J Genet. 2011 Aug; 90(2):187-90.
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  27. Rogers RL, Hartl DL. Chimeric genes as a source of rapid evolution in Drosophila melanogaster. Mol Biol Evol. 2012 Feb; 29(2):517-29.
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  28. Costanzo MS, Brown KM, Hartl DL. Fitness trade-offs in the evolution of dihydrofolate reductase and drug resistance in Plasmodium falciparum. PLoS One. 2011; 6(5):e19636.
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  29. Paredes S, Branco AT, Hartl DL, Maggert KA, Lemos B. Ribosomal DNA deletions modulate genome-wide gene expression: "rDNA-sensitive" genes and natural variation. PLoS Genet. 2011 Apr; 7(4):e1001376.
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  30. Van Tyne D, Park DJ, Schaffner SF, Neafsey DE, Angelino E, Cortese JF, Barnes KG, Rosen DM, Lukens AK, Daniels RF, Milner DA, Johnson CA, Shlyakhter I, Grossman SR, Becker JS, Yamins D, Karlsson EK, Ndiaye D, Sarr O, Mboup S, Happi C, Furlotte NA, Eskin E, Kang HM, Hartl DL, Birren BW, Wiegand RC, Lander ES, Wirth DF, Volkman SK, Sabeti PC. Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum. PLoS Genet. 2011 Apr; 7(4):e1001383.
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  31. Zhou J, Lemos B, Dopman EB, Hartl DL. Copy-number variation: the balance between gene dosage and expression in Drosophila melanogaster. Genome Biol Evol. 2011; 3:1014-24.
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  32. Geiler-Samerotte KA, Dion MF, Budnik BA, Wang SM, Hartl DL, Drummond DA. Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):680-5.
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  33. Araripe LO, Montenegro H, Lemos B, Hartl DL. Fine-scale genetic mapping of a hybrid sterility factor between Drosophila simulans and D. mauritiana: the varied and elusive functions of "speciation genes". BMC Evol Biol. 2010; 10:385.
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  34. Lemos B, Branco AT, Hartl DL. Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. Proc Natl Acad Sci U S A. 2010 Sep 7; 107(36):15826-31.
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  35. Brown KM, Costanzo MS, Xu W, Roy S, Lozovsky ER, Hartl DL. Compensatory mutations restore fitness during the evolution of dihydrofolate reductase. Mol Biol Evol. 2010 Dec; 27(12):2682-90.
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  36. Jiang PP, Hartl DL, Lemos B. Y not a dead end: epistatic interactions between Y-linked regulatory polymorphisms and genetic background affect global gene expression in Drosophila melanogaster. Genetics. 2010 Sep; 186(1):109-18.
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  37. Rogers RL, Bedford T, Lyons AM, Hartl DL. Adaptive impact of the chimeric gene Quetzalcoatl in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):10943-8.
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  38. Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, Berenbaum MR, Berlin OB, Bjorkman PJ, Blackburn E, Blamont JE, Botchan MR, Boyer JS, Boyle EA, Branton D, Briggs SP, Briggs WR, Brill WJ, Britten RJ, Broecker WS, Brown JH, Brown PO, Brunger AT, Cairns J, Canfield DE, Carpenter SR, Carrington JC, Cashmore AR, Castilla JC, Cazenave A, Chapin FS, Ciechanover AJ, Clapham DE, Clark WC, Clayton RN, Coe MD, Conwell EM, Cowling EB, Cowling RM, Cox CS, Croteau RB, Crothers DM, Crutzen PJ, Daily GC, Dalrymple GB, Dangl JL, Darst SA, Davies DR, Davis MB, De Camilli PV, Dean C, DeFries RS, Deisenhofer J, Delmer DP, DeLong EF, DeRosier DJ, Diener TO, Dirzo R, Dixon JE, Donoghue MJ, Doolittle RF, Dunne T, Ehrlich PR, Eisenstadt SN, Eisner T, Emanuel KA, Englander SW, Ernst WG, Falkowski PG, Feher G, Ferejohn JA, Fersht A, Fischer EH, Fischer R, Flannery KV, Frank J, Frey PA, Fridovich I, Frieden C, Futuyma DJ, Gardner WR, Garrett CJ, Gilbert W, Goldberg RB, Goodenough WH, Goodman CS, Goodman M, Greengard P, Hake S, Hammel G, Hanson S, Harrison SC, Hart SR, Hartl DL, Haselkorn R, Hawkes K, Hayes JM, Hille B, Hökfelt T, House JS, Hout M, Hunten DM, Izquierdo IA, Jagendorf AT, Janzen DH, Jeanloz R, Jencks CS, Jury WA, Kaback HR, Kailath T, Kay P, Kay SA, Kennedy D, Kerr A, Kessler RC, Khush GS, Kieffer SW, Kirch PV, Kirk K, Kivelson MG, Klinman JP, Klug A, Knopoff L, Kornberg H, Kutzbach JE, Lagarias JC, Lambeck K, Landy A, Langmuir CH, Larkins BA, Le Pichon XT, Lenski RE, Leopold EB, Levin SA, Levitt M, Likens GE, Lippincott-Schwartz J, Lorand L, Lovejoy CO, Lynch M, Mabogunje AL, Malone TF, Manabe S, Marcus J, Massey DS, McWilliams JC, Medina E, Melosh HJ, Meltzer DJ, Michener CD, Miles EL, Mooney HA, Moore PB, Morel FM, Mosley-Thompson ES, Moss B, Munk WH, Myers N, Nair GB, Nathans J, Nester EW, Nicoll RA, Novick RP, O'Connell JF, Olsen PE, Opdyke ND, Oster GF, Ostrom E, Pace NR, Paine RT, Palmiter RD, Pedlosky J, Petsko GA, Pettengill GH, Philander SG, Piperno DR, Pollard TD, Price PB, Reichard PA, Reskin BF, Ricklefs RE, Rivest RL, Roberts JD, Romney AK, Rossmann MG, Russell DW, Rutter WJ, Sabloff JA, Sagdeev RZ, Sahlins MD, Salmond A, Sanes JR, Schekman R, Schellnhuber J, Schindler DW, Schmitt J, Schneider SH, Schramm VL, Sederoff RR, Shatz CJ, Sherman F, Sidman RL, Sieh K, Simons EL, Singer BH, Singer MF, Skyrms B, Sleep NH, Smith BD, Snyder SH, Sokal RR, Spencer CS, Steitz TA, Strier KB, Südhof TC, Taylor SS, Terborgh J, Thomas DH, Thompson LG, Tjian RT, Turner MG, Uyeda S, Valentine JW, Valentine JS, Van Etten JL, van Holde KE, Vaughan M, Verba S, von Hippel PH, Wake DB, Walker A, Walker JE, Watson EB, Watson PJ, Weigel D, Wessler SR, West-Eberhard MJ, White TD, Wilson WJ, Wolfenden RV, Wood JA, Woodwell GM, Wright HE, Wu C, Wunsch C, Zoback ML. Climate change and the integrity of science. Science. 2010 May 7; 328(5979):689-90.
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  39. Zilversmit MM, Volkman SK, DePristo MA, Wirth DF, Awadalla P, Hartl DL. Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome. Mol Biol Evol. 2010 Sep; 27(9):2198-209.
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  40. Fontanillas P, Landry CR, Wittkopp PJ, Russ C, Gruber JD, Nusbaum C, Hartl DL. Key considerations for measuring allelic expression on a genomic scale using high-throughput sequencing. Mol Ecol. 2010 Mar; 19 Suppl 1:212-27.
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  41. Gunawardena S, Karunaweera ND, Ferreira MU, Phone-Kyaw M, Pollack RJ, Alifrangis M, Rajakaruna RS, Konradsen F, Amerasinghe PH, Schousboe ML, Galappaththy GN, Abeyasinghe RR, Hartl DL, Wirth DF. Geographic structure of Plasmodium vivax: microsatellite analysis of parasite populations from Sri Lanka, Myanmar, and Ethiopia. Am J Trop Med Hyg. 2010 Feb; 82(2):235-42.
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  42. Sackton TB, Kulathinal RJ, Bergman CM, Quinlan AR, Dopman EB, Carneiro M, Marth GT, Hartl DL, Clark AG. Population genomic inferences from sparse high-throughput sequencing of two populations of Drosophila melanogaster. Genome Biol Evol. 2009; 1:449-65.
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  43. Kingan SB, Garrigan D, Hartl DL. Recurrent selection on the Winters sex-ratio genes in Drosophila simulans. Genetics. 2010 Jan; 184(1):253-65.
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  44. Carneiro M, Hartl DL. Colloquium papers: Adaptive landscapes and protein evolution. Proc Natl Acad Sci U S A. 2010 Jan 26; 107 Suppl 1:1747-51.
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  45. Brown KM, Depristo MA, Weinreich DM, Hartl DL. Temporal constraints on the incorporation of regulatory mutants in evolutionary pathways. Mol Biol Evol. 2009 Nov; 26(11):2455-62.
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  46. Lozovsky ER, Chookajorn T, Brown KM, Imwong M, Shaw PJ, Kamchonwongpaisan S, Neafsey DE, Weinreich DM, Hartl DL. Stepwise acquisition of pyrimethamine resistance in the malaria parasite. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12025-30.
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  47. Nebrich G, Herrmann M, Hartl D, Diedrich M, Kreitler T, Wierling C, Klose J, Giavalisco P, Zabel C, Mao L. PROTEOMER: A workflow-optimized laboratory information management system for 2-D electrophoresis-centered proteomics. Proteomics. 2009 Apr; 9(7):1795-808.
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  48. Mayer DC, Cofie J, Jiang L, Hartl DL, Tracy E, Kabat J, Mendoza LH, Miller LH. Glycophorin B is the erythrocyte receptor of Plasmodium falciparum erythrocyte-binding ligand, EBL-1. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5348-52.
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  49. Bedford T, Hartl DL. Optimization of gene expression by natural selection. Proc Natl Acad Sci U S A. 2009 Jan 27; 106(4):1133-8.
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  50. Neafsey DE, Schaffner SF, Volkman SK, Park D, Montgomery P, Milner DA, Lukens A, Rosen D, Daniels R, Houde N, Cortese JF, Tyndall E, Gates C, Stange-Thomann N, Sarr O, Ndiaye D, Ndir O, Mboup S, Ferreira MU, Moraes Sdo L, Dash AP, Chitnis CE, Wiegand RC, Hartl DL, Birren BW, Lander ES, Sabeti PC, Wirth DF. Genome-wide SNP genotyping highlights the role of natural selection in Plasmodium falciparum population divergence. Genome Biol. 2008; 9(12):R171.
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  51. Zabel C, Mao L, Woodman B, Rohe M, Wacker MA, Kläre Y, Koppelstätter A, Nebrich G, Klein O, Grams S, Strand A, Luthi-Carter R, Hartl D, Klose J, Bates GP. A large number of protein expression changes occur early in life and precede phenotype onset in a mouse model for huntington disease. Mol Cell Proteomics. 2009 Apr; 8(4):720-34.
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  52. Rogers RL, Bedford T, Hartl DL. Formation and longevity of chimeric and duplicate genes in Drosophila melanogaster. Genetics. 2009 Jan; 181(1):313-22.
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  53. Lemos B, Araripe LO, Fontanillas P, Hartl DL. Dominance and the evolutionary accumulation of cis- and trans-effects on gene expression. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14471-6.
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  54. Hegreness M, Shoresh N, Damian D, Hartl D, Kishony R. Accelerated evolution of resistance in multidrug environments. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):13977-81.
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  55. Hartl D, Rohe M, Mao L, Staufenbiel M, Zabel C, Klose J. Impairment of adolescent hippocampal plasticity in a mouse model for Alzheimer's disease precedes disease phenotype. PLoS One. 2008; 3(7):e2759.
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  56. Lynch M, Sung W, Morris K, Coffey N, Landry CR, Dopman EB, Dickinson WJ, Okamoto K, Kulkarni S, Hartl DL, Thomas WK. A genome-wide view of the spectrum of spontaneous mutations in yeast. Proc Natl Acad Sci U S A. 2008 Jul 8; 105(27):9272-7.
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  57. Bedford T, Wapinski I, Hartl DL. Overdispersion of the molecular clock varies between yeast, Drosophila and mammals. Genetics. 2008 Jun; 179(2):977-84.
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  58. Bedford T, Hartl DL. Overdispersion of the molecular clock: temporal variation of gene-specific substitution rates in Drosophila. Mol Biol Evol. 2008 Aug; 25(8):1631-8.
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  59. Baines JF, Sawyer SA, Hartl DL, Parsch J. Effects of X-linkage and sex-biased gene expression on the rate of adaptive protein evolution in Drosophila. Mol Biol Evol. 2008 Aug; 25(8):1639-50.
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  60. Brown KM, Landry CR, Hartl DL, Cavalieri D. Cascading transcriptional effects of a naturally occurring frameshift mutation in Saccharomyces cerevisiae. Mol Ecol. 2008 Jun; 17(12):2985-97.
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  61. Zabel C, Andreew A, Mao L, Hartl D. Protein expression overlap: more important than which proteins change in expression? Expert Rev Proteomics. 2008 Apr; 5(2):187-205.
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  62. Hartl D, Irmler M, Römer I, Mader MT, Mao L, Zabel C, de Angelis MH, Beckers J, Klose J. Transcriptome and proteome analysis of early embryonic mouse brain development. Proteomics. 2008 Mar; 8(6):1257-65.
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  63. Irmler M, Hartl D, Schmidt T, Schuchhardt J, Lach C, Meyer HE, Hrabé de Angelis M, Klose J, Beckers J. An approach to handling and interpretation of ambiguous data in transcriptome and proteome comparisons. Proteomics. 2008 Mar; 8(6):1165-9.
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  64. Karunaweera ND, Ferreira MU, Munasinghe A, Barnwell JW, Collins WE, King CL, Kawamoto F, Hartl DL, Wirth DF. Extensive microsatellite diversity in the human malaria parasite Plasmodium vivax. Gene. 2008 Feb 29; 410(1):105-12.
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  65. Lemos B, Araripe LO, Hartl DL. Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Science. 2008 Jan 4; 319(5859):91-3.
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  66. Amodu OK, Hartl DL, Roy SW. Patterns of polymorphism in genomic regions flanking three highly polymorphic surface antigens in Plasmodium falciparum. Mol Biochem Parasitol. 2008 May; 159(1):1-6.
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  67. Dopman EB, Hartl DL. A portrait of copy-number polymorphism in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2007 Dec 11; 104(50):19920-5.
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  68. Mao L, Zabel C, Herrmann M, Nolden T, Mertes F, Magnol L, Chabert C, Hartl D, Herault Y, Delabar JM, Manke T, Himmelbauer H, Klose J. Proteomic shifts in embryonic stem cells with gene dose modifications suggest the presence of balancer proteins in protein regulatory networks. PLoS One. 2007; 2(11):e1218.
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  69. Tao Y, Masly JP, Araripe L, Ke Y, Hartl DL. A sex-ratio meiotic drive system in Drosophila simulans. I: an autosomal suppressor. PLoS Biol. 2007 Nov 6; 5(11):e292.
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  70. Tao Y, Araripe L, Kingan SB, Ke Y, Xiao H, Hartl DL. A sex-ratio meiotic drive system in Drosophila simulans. II: an X-linked distorter. PLoS Biol. 2007 Nov 6; 5(11):e293.
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  71. Chookajorn T, Costanzo MS, Hartl DL, Deitsch KW. Malaria: a peek at the var variorum. Trends Parasitol. 2007 Dec; 23(12):563-5.
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  72. Fontanillas P, Hartl DL, Reuter M. Genome organization and gene expression shape the transposable element distribution in the Drosophila melanogaster euchromatin. PLoS Genet. 2007 Nov; 3(11):e210.
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  73. Landry CR, Hartl DL, Ranz JM. Genome clashes in hybrids: insights from gene expression. Heredity (Edinb). 2007 Nov; 99(5):483-93.
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  74. DePristo MA, Hartl DL, Weinreich DM. Mutational reversions during adaptive protein evolution. Mol Biol Evol. 2007 Aug; 24(8):1608-10.
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  75. Landry CR, Lemos B, Rifkin SA, Dickinson WJ, Hartl DL. Genetic properties influencing the evolvability of gene expression. Science. 2007 Jul 6; 317(5834):118-21.
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  76. Sawyer SA, Parsch J, Zhang Z, Hartl DL. Prevalence of positive selection among nearly neutral amino acid replacements in Drosophila. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6504-10.
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  77. Ferreira MU, Karunaweera ND, da Silva-Nunes M, da Silva NS, Wirth DF, Hartl DL. Population structure and transmission dynamics of Plasmodium vivax in rural Amazonia. J Infect Dis. 2007 Apr 15; 195(8):1218-26.
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  78. Hartl DL, Fairbanks DJ. Mud sticks: on the alleged falsification of Mendel's data. Genetics. 2007 Mar; 175(3):975-9.
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  79. Landry CR, Castillo-Davis CI, Ogura A, Liu JS, Hartl DL. Systems-level analysis and evolution of the phototransduction network in Drosophila. Proc Natl Acad Sci U S A. 2007 Feb 27; 104(9):3283-8.
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  80. Gunasekera AM, Wickramarachchi T, Neafsey DE, Ganguli I, Perera L, Premaratne PH, Hartl D, Handunnetti SM, Udagama-Randeniya PV, Wirth DF. Genetic diversity and selection at the Plasmodium vivax apical membrane antigen-1 (PvAMA-1) locus in a Sri Lankan population. Mol Biol Evol. 2007 Apr; 24(4):939-47.
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  81. Chookajorn T, Dzikowski R, Frank M, Li F, Jiwani AZ, Hartl DL, Deitsch KW. Epigenetic memory at malaria virulence genes. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):899-902.
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  82. Volkman SK, Sabeti PC, DeCaprio D, Neafsey DE, Schaffner SF, Milner DA, Daily JP, Sarr O, Ndiaye D, Ndir O, Mboup S, Duraisingh MT, Lukens A, Derr A, Stange-Thomann N, Waggoner S, Onofrio R, Ziaugra L, Mauceli E, Gnerre S, Jaffe DB, Zainoun J, Wiegand RC, Birren BW, Hartl DL, Galagan JE, Lander ES, Wirth DF. A genome-wide map of diversity in Plasmodium falciparum. Nat Genet. 2007 Jan; 39(1):113-9.
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  83. Roy SW, Ferreira MU, Hartl DL. Evolution of allelic dimorphism in malarial surface antigens. Heredity (Edinb). 2008 Feb; 100(2):103-10.
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  84. Volkman SK, Lozovsky E, Barry AE, Bedford T, Bethke L, Myrick A, Day KP, Hartl DL, Wirth DF, Sawyer SA. Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum. Gene. 2007 Jan 31; 387(1-2):1-6.
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  85. Bethke LL, Zilversmit M, Nielsen K, Daily J, Volkman SK, Ndiaye D, Lozovsky ER, Hartl DL, Wirth DF. Duplication, gene conversion, and genetic diversity in the species-specific acyl-CoA synthetase gene family of Plasmodium falciparum. Mol Biochem Parasitol. 2006 Nov; 150(1):10-24.
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  86. Ferreira MU, Hartl DL. Plasmodium falciparum: worldwide sequence diversity and evolution of the malaria vaccine candidate merozoite surface protein-2 (MSP-2). Exp Parasitol. 2007 Jan; 115(1):32-40.
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  87. Ponce R, Hartl DL. The evolution of the novel Sdic gene cluster in Drosophila melanogaster. Gene. 2006 Jul 19; 376(2):174-83.
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  88. Roy SW, Hartl DL. Very little intron loss/gain in Plasmodium: intron loss/gain mutation rates and intron number. Genome Res. 2006 Jun; 16(6):750-6.
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  89. DePristo MA, Zilversmit MM, Hartl DL. On the abundance, amino acid composition, and evolutionary dynamics of low-complexity regions in proteins. Gene. 2006 Aug 15; 378:19-30.
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  90. Chookajorn T, Hartl DL. Position-specific polymorphism of Plasmodium falciparum Stuttering motif in a PHISTc PFI1780w. Exp Parasitol. 2006 Oct; 114(2):126-8.
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  91. Weinreich DM, Delaney NF, Depristo MA, Hartl DL. Darwinian evolution can follow only very few mutational paths to fitter proteins. Science. 2006 Apr 7; 312(5770):111-4.
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  106. Meiklejohn CD, Kim Y, Hartl DL, Parsch J. Identification of a locus under complex positive selection in Drosophila simulans by haplotype mapping and composite-likelihood estimation. Genetics. 2004 Sep; 168(1):265-79.
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  110. Castillo-Davis CI, Bedford TB, Hartl DL. Accelerated rates of intron gain/loss and protein evolution in duplicate genes in human and mouse malaria parasites. Mol Biol Evol. 2004 Jul; 21(7):1422-7.
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  111. Ranz JM, Namgyal K, Gibson G, Hartl DL. Anomalies in the expression profile of interspecific hybrids of Drosophila melanogaster and Drosophila simulans. Genome Res. 2004 Mar; 14(3):373-9.
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  114. Tao Y, Hartl DL. Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. III. Heterogeneous accumulation of hybrid incompatibilities, degree of dominance, and implications for Haldane's rule. Evolution. 2003 Nov; 57(11):2580-98.
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  116. Meiklejohn CD, Parsch J, Ranz JM, Hartl DL. Rapid evolution of male-biased gene expression in Drosophila. Proc Natl Acad Sci U S A. 2003 Aug 19; 100(17):9894-9.
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  117. Tao Y, Zeng ZB, Li J, Hartl DL, Laurie CC. Genetic dissection of hybrid incompatibilities between Drosophila simulans and D. mauritiana. II. Mapping hybrid male sterility loci on the third chromosome. Genetics. 2003 Aug; 164(4):1399-418.
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  119. Ranz JM, Ponce AR, Hartl DL, Nurminsky D. Origin and evolution of a new gene expressed in the Drosophila sperm axoneme. Genetica. 2003 Jul; 118(2-3):233-44.
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  127. Winzeler EA, Castillo-Davis CI, Oshiro G, Liang D, Richards DR, Zhou Y, Hartl DL. Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays. Genetics. 2003 Jan; 163(1):79-89.
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  128. Sawyer SA, Kulathinal RJ, Bustamante CD, Hartl DL. Bayesian analysis suggests that most amino acid replacements in Drosophila are driven by positive selection. J Mol Evol. 2003; 57 Suppl 1:S154-64.
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  129. Cavalieri D, McGovern PE, Hartl DL, Mortimer R, Polsinelli M. Evidence for S. cerevisiae fermentation in ancient wine. J Mol Evol. 2003; 57 Suppl 1:S226-32.
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  134. Grosu P, Townsend JP, Hartl DL, Cavalieri D. Pathway Processor: a tool for integrating whole-genome expression results into metabolic networks. Genome Res. 2002 Jul; 12(7):1121-6.
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  136. Castillo-Davis CI, Hartl DL. Genome evolution and developmental constraint in Caenorhabditis elegans. Mol Biol Evol. 2002 May; 19(5):728-35.
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  143. Parsch J, Meiklejohn CD, Hartl DL. Patterns of DNA sequence variation suggest the recent action of positive selection in the janus-ocnus region of Drosophila simulans. Genetics. 2001 Oct; 159(2):647-57.
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  145. Parsch J, Meiklejohn CD, Hauschteck-Jungen E, Hunziker P, Hartl DL. Molecular evolution of the ocnus and janus genes in the Drosophila melanogaster species subgroup. Mol Biol Evol. 2001 May; 18(5):801-11.
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  146. Bensasson D, Petrov DA, Zhang DX, Hartl DL, Hewitt GM. Genomic gigantism: DNA loss is slow in mountain grasshoppers. Mol Biol Evol. 2001 Feb; 18(2):246-53.
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  149. Goldfeld AE, Leung JY, Sawyer SA, Hartl DL. Post-genomics and the neutral theory: variation and conservation in the tumor necrosis factor-alpha promoter. Gene. 2000 Dec 30; 261(1):19-25.
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  151. Cavalieri D, Townsend JP, Hartl DL. Manifold anomalies in gene expression in a vineyard isolate of Saccharomyces cerevisiae revealed by DNA microarray analysis. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12369-74.
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  152. Parsch J, Russell JA, Beerman I, Hartl DL, Stephan W. Deletion of a conserved regulatory element in the Drosophila Adh gene leads to increased alcohol dehydrogenase activity but also delays development. Genetics. 2000 Sep; 156(1):219-27.
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  153. Leung JY, McKenzie FE, Uglialoro AM, Flores-Villanueva PO, Sorkin BC, Yunis EJ, Hartl DL, Goldfeld AE. Identification of phylogenetic footprints in primate tumor necrosis factor-alpha promoters. Proc Natl Acad Sci U S A. 2000 Jun 6; 97(12):6614-8.
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  158. Bustamante CD, Townsend JP, Hartl DL. Solvent accessibility and purifying selection within proteins of Escherichia coli and Salmonella enterica. Mol Biol Evol. 2000 Feb; 17(2):301-8.
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  160. Siegal ML, Hartl DL. Application of Cre/loxP in Drosophila. Site-specific recombination and transgene coplacement. Methods Mol Biol. 2000; 136:487-95.
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  164. Boyd EF, Hartl DL. Analysis of the type 1 pilin gene cluster fim in Salmonella: its distinct evolutionary histories in the 5' and 3' regions. J Bacteriol. 1999 Feb; 181(4):1301-8.
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  168. Nurminsky DI, Nurminskaya MV, Benevolenskaya EV, Shevelyov YY, Hartl DL, Gvozdev VA. Cytoplasmic dynein intermediate-chain isoforms with different targeting properties created by tissue-specific alternative splicing. Mol Cell Biol. 1998 Nov; 18(11):6816-25.
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  170. Uglialoro AM, Turbay D, Pesavento PA, Delgado JC, McKenzie FE, Gribben JG, Hartl D, Yunis EJ, Goldfeld AE. Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-alpha gene promoter. Tissue Antigens. 1998 Oct; 52(4):359-67.
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  171. Boyd EF, Hartl DL. Diversifying selection governs sequence polymorphism in the major adhesin proteins fimA, papA, and sfaA of Escherichia coli. J Mol Evol. 1998 Sep; 47(3):258-67.
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  172. Boyd EF, Hartl DL. Salmonella virulence plasmid. Modular acquisition of the spv virulence region by an F-plasmid in Salmonella enterica subspecies I and insertion into the chromosome of subspecies II, IIIa, IV and VII isolates. Genetics. 1998 Jul; 149(3):1183-90.
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  177. Boyd EF, Hartl DL. Chromosomal regions specific to pathogenic isolates of Escherichia coli have a phylogenetically clustered distribution. J Bacteriol. 1998 Mar; 180(5):1159-65.
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  180. Vieira CP, Vieira J, Hartl DL. The evolution of small gene clusters: evidence for an independent origin of the maltase gene cluster in Drosophila virilis and Drosophila melanogaster. Mol Biol Evol. 1997 Oct; 14(10):985-93.
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  186. Rich SM, Rosenthal BM, Telford SR, Spielman A, Hartl DL, Ayala FJ. Heterogeneity of the internal transcribed spacer (ITS-2) region within individual deer ticks. Insect Mol Biol. 1997 May; 6(2):123-9.
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  195. Siegal ML, Hartl DL. Transgene Coplacement and high efficiency site-specific recombination with the Cre/loxP system in Drosophila. Genetics. 1996 Oct; 144(2):715-26.
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  200. Ayala FJ, Wetterer JK, Longino JT, Hartl DL. Molecular phylogeny of Azteca ants (Hymenoptera:Formicidae) and the colonization of Cecropia trees. Mol Phylogenet Evol. 1996 Apr; 5(2):423-8.
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  204. Armstrong PM, Rich SM, Smith RD, Hartl DL, Spielman A, Telford SR. A new Borrelia infecting Lone Star ticks. Lancet. 1996 Jan 6; 347(8993):67-8.
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  209. Segarra C, Lozovskaya ER, Ribó G, Aguadé M, Hartl DL. P1 clones from Drosophila melanogaster as markers to study the chromosomal evolution of Muller's A element in two species of the obscura group of Drosophila. Chromosoma. 1995 Nov; 104(2):129-36.
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  213. Chang BS, Crandall KA, Carulli JP, Hartl DL. Opsin phylogeny and evolution: a model for blue shifts in wavelength regulation. Mol Phylogenet Evol. 1995 Mar; 4(1):31-43.
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  225. Nurminsky DI, Hartl DL. Amplification of the ends of DNA fragments cloned in bacteriophage P1. Biotechniques. 1993 Aug; 15(2):201-2, 206-8.
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  226. Moriyama EN, Hartl DL. Codon usage bias and base composition of nuclear genes in Drosophila. Genetics. 1993 Jul; 134(3):847-58.
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  227. Lidholm DA, Lohe AR, Hartl DL. The transposable element mariner mediates germline transformation in Drosophila melanogaster. Genetics. 1993 Jul; 134(3):859-68.
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  228. Carulli JP, Krane DE, Hartl DL, Ochman H. Compositional heterogeneity and patterns of molecular evolution in the Drosophila genome. Genetics. 1993 Jul; 134(3):837-45.
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  229. Hartl DL, Lewontin RC. DNA fingerprinting report. Science. 1993 Apr 23; 260(5107):473-4.
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  230. Lozovskaya ER, Petrov DA, Hartl DL. A combined molecular and cytogenetic approach to genome evolution in Drosophila using large-fragment DNA cloning. Chromosoma. 1993 Mar; 102(4):253-66.
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  231. Ochman H, Ayala FJ, Hartl DL. Use of polymerase chain reaction to amplify segments outside boundaries of known sequences. Methods Enzymol. 1993; 218:309-21.
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  232. Ayala FJ, Chang BS, Hartl DL. Molecular evolution of the Rh3 gene in Drosophila. Genetica. 1993; 92(1):23-32.
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  233. Lawrence JG, Hartl DL, Ochman H. Sequencing products of polymerase chain reaction. Methods Enzymol. 1993; 218:26-35.
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  234. Sawyer SA, Hartl DL. Population genetics of polymorphism and divergence. Genetics. 1992 Dec; 132(4):1161-76.
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  235. Danilevskaya ON, Petrov DA, Pavlova MN, Koga A, Kurenova EV, Hartl DL. A repetitive DNA element, associated with telomeric sequences in Drosophila melanogaster, contains open reading frames. Chromosoma. 1992 Dec; 102(1):32-40.
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  236. Hartl DL. Population genetics of microbial organisms. Curr Opin Genet Dev. 1992 Dec; 2(6):937-42.
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  237. Krane DE, Allen RW, Sawyer SA, Petrov DA, Hartl DL. Genetic differences at four DNA typing loci in Finnish, Italian, and mixed Caucasian populations. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10583-7.
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  238. Hartl DL, Lozovskaya ER. The Drosophila genome project: current status of the physical map. Comp Biochem Physiol B. 1992 Sep; 103(1):1-8.
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  239. Carulli JP, Hartl DL. Variable rates of evolution among Drosophila opsin genes. Genetics. 1992 Sep; 132(1):193-204.
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  240. Lawrence JG, Hartl DL. Inference of horizontal genetic transfer from molecular data: an approach using the bootstrap. Genetics. 1992 Jul; 131(3):753-60.
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  241. Hartl DL, Orel V. What did Gregor Mendel think he discovered? Genetics. 1992 Jun; 131(2):245-53.
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  242. Lawrence JG, Ochman H, Hartl DL. The evolution of insertion sequences within enteric bacteria. Genetics. 1992 May; 131(1):9-20.
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  243. Capy P, Koga A, David JR, Hartl DL. Sequence analysis of active mariner elements in natural populations of Drosophila simulans. Genetics. 1992 Mar; 130(3):499-506.
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  244. Lewontin RC, Hartl DL. Response. Science. 1992 Feb 28; 255(5048):1053-4.
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  245. Hartl DL, Ajioka JW, Cai H, Lohe AR, Lozovskaya ER, Smoller DA, Duncan IW. Towards a Drosophila genome map. Trends Genet. 1992 Feb; 8(2):70-5.
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  246. Capy P, David JR, Hartl DL. Evolution of the transposable element mariner in the Drosophila melanogaster species group. Genetica. 1992; 86(1-3):37-46.
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  247. Hartl DL, Lozovskaya ER, Lawrence JG. Nonautonomous transposable elements in prokaryotes and eukaryotes. Genetica. 1992; 86(1-3):47-53.
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  248. Lewontin RC, Hartl DL. Population genetics in forensic DNA typing. Science. 1991 Dec 20; 254(5039):1745-50.
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  249. Maruyama K, Hartl DL. Evidence for interspecific transfer of the transposable element mariner between Drosophila and Zaprionus. J Mol Evol. 1991 Dec; 33(6):514-24.
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  250. Capy P, Maruyama K, David JR, Hartl DL. Insertion sites of the transposable element mariner are fixed in the genome of Drosophila sechellia. J Mol Evol. 1991 Nov; 33(5):450-6.
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  251. Merriam J, Ashburner M, Hartl DL, Kafatos FC. Toward cloning and mapping the genome of Drosophila. Science. 1991 Oct 11; 254(5029):221-5.
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  252. Krane DE, Hartl DL, Ochman H. Rapid determination of nucleotide content and its application to the study of genome structure. Nucleic Acids Res. 1991 Oct 11; 19(19):5181-5.
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  253. Palazzolo MJ, Sawyer SA, Martin CH, Smoller DA, Hartl DL. Optimized strategies for sequence-tagged-site selection in genome mapping. Proc Natl Acad Sci U S A. 1991 Sep 15; 88(18):8034-8.
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  254. Lawrence JG, Hartl DL, Ochman H. Molecular considerations in the evolution of bacterial genes. J Mol Evol. 1991 Sep; 33(3):241-50.
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  255. Smoller DA, Petrov D, Hartl DL. Characterization of bacteriophage P1 library containing inserts of Drosophila DNA of 75-100 kilobase pairs. Chromosoma. 1991 Sep; 100(8):487-94.
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  256. Ajioka JW, Smoller DA, Jones RW, Carulli JP, Vellek AE, Garza D, Link AJ, Duncan IW, Hartl DL. Drosophila genome project: one-hit coverage in yeast artificial chromosomes. Chromosoma. 1991 Sep; 100(8):495-509.
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  257. Lawrence JG, Ochman H, Hartl DL. Molecular and evolutionary relationships among enteric bacteria. J Gen Microbiol. 1991 Aug; 137(8):1911-21.
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  258. Maruyama K, Schoor KD, Hartl DL. Identification of nucleotide substitutions necessary for trans-activation of mariner transposable elements in Drosophila: analysis of naturally occurring elements. Genetics. 1991 Aug; 128(4):777-84.
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  259. Maruyama K, Hartl DL. Evolution of the transposable element mariner in Drosophila species. Genetics. 1991 Jun; 128(2):319-29.
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  260. Medhora M, Maruyama K, Hartl DL. Molecular and functional analysis of the mariner mutator element Mos1 in Drosophila. Genetics. 1991 Jun; 128(2):311-8.
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  261. Garza D, Medhora M, Koga A, Hartl DL. Introduction of the transposable element mariner into the germline of Drosophila melanogaster. Genetics. 1991 Jun; 128(2):303-10.
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  262. Danilevskaya ON, Kurenova EV, Pavlova MN, Bebehov DV, Link AJ, Koga A, Vellek A, Hartl DL. He-T family DNA sequences in the Y chromosome of Drosophila melanogaster share homology with the X-linked stellate genes. Chromosoma. 1991 Feb; 100(2):118-24.
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  263. Lawrence JG, Hartl DL. Unusual codon bias occurring within insertion sequences in Escherichia coli. Genetica. 1991; 84(1):23-9.
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  264. Garza D, Medhora MM, Hartl DL. Drosophila nonsense suppressors: functional analysis in Saccharomyces cerevisiae, Drosophila tissue culture cells and Drosophila melanogaster. Genetics. 1990 Nov; 126(3):625-37.
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  265. DuBose RF, Hartl DL. The molecular evolution of bacterial alkaline phosphatase: correlating variation among enteric bacteria to experimental manipulations of the protein. Mol Biol Evol. 1990 Nov; 7(6):547-77.
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  266. Capy P, Chakrani F, Lemeunier F, Hartl DL, David JR. Active mariner transposable elements are widespread in natural populations of Drosophila simulans. Proc Biol Sci. 1990 Oct 22; 242(1303):57-60.
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  267. Ochman H, Ajioka JW, Garza D, Hartl DL. Inverse polymerase chain reaction. Biotechnology (N Y). 1990 Aug; 8(8):759-60.
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  268. DuBose RF, Hartl DL. Rapid purification of PCR products for DNA sequencing using Sepharose CL-6B spin columns. Biotechniques. 1990 Mar; 8(3):271-4.
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  269. DuBose RF, Hartl DL. An experimental approach to testing modular evolution: directed replacement of alpha-helices in a bacterial protein. Proc Natl Acad Sci U S A. 1989 Dec; 86(24):9966-70.
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  270. Garza D, Ajioka JW, Burke DT, Hartl DL. Mapping the Drosophila genome with yeast artificial chromosomes. Science. 1989 Nov 3; 246(4930):641-6.
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  271. Hartl DL. Evolving theories of enzyme evolution. Genetics. 1989 May; 122(1):1-6.
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  272. Hall BG, Parker LL, Betts PW, DuBose RF, Sawyer SA, Hartl DL. IS103, a new insertion element in Escherichia coli: characterization and distribution in natural populations. Genetics. 1989 Mar; 121(3):423-31.
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  273. Hartl DL. The physiology of weak selection. Genome. 1989; 31(1):183-9.
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  274. Lawrence JG, Dykhuizen DE, DuBose RF, Hartl DL. Phylogenetic analysis using insertion sequence fingerprinting in Escherichia coli. Mol Biol Evol. 1989 Jan; 6(1):1-14.
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  275. Miller RD, Dykhuizen DE, Hartl DL. Fitness effects of a deletion mutation increasing transcription of the 6-phosphogluconate dehydrogenase gene in Escherichia coli. Mol Biol Evol. 1988 Nov; 5(6):691-703.
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  276. Ochman H, Gerber AS, Hartl DL. Genetic applications of an inverse polymerase chain reaction. Genetics. 1988 Nov; 120(3):621-3.
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  277. Dean AM, Dykhuizen DE, Hartl DL. Fitness effects of amino acid replacements in the beta-galactosidase of Escherichia coli. Mol Biol Evol. 1988 Sep; 5(5):469-85.
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  278. DuBose RF, Dykhuizen DE, Hartl DL. Genetic exchange among natural isolates of bacteria: recombination within the phoA gene of Escherichia coli. Proc Natl Acad Sci U S A. 1988 Sep; 85(18):7036-40.
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  279. Medhora MM, MacPeek AH, Hartl DL. Excision of the Drosophila transposable element mariner: identification and characterization of the Mos factor. EMBO J. 1988 Jul; 7(7):2185-9.
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  280. Stebbins GL, Hartl DL. Comparative evolution: latent potentials for anagenetic advance. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5141-5.
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  281. Bryan GJ, Hartl DL. Maternally inherited transposon excision in Drosophila simulans. Science. 1988 Apr 8; 240(4849):215-7.
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  282. Hartl DL, Sawyer SA. Why do unrelated insertion sequences occur together in the genome of Escherichia coli? Genetics. 1988 Mar; 118(3):537-41.
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  283. Sawyer SA, Dykhuizen DE, Hartl DL. Confidence interval for the number of selectively neutral amino acid polymorphisms. Proc Natl Acad Sci U S A. 1987 Sep; 84(17):6225-8.
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  284. Hartl DL. The molecular approach to evolution: molecular evolutionary genetics. Science. 1987 Aug 14; 237(4816):782.
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  285. Bryan GJ, Jacobson JW, Hartl DL. Heritable somatic excision of a Drosophila transposon. Science. 1987 Mar 27; 235(4796):1636-8.
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  286. Dykhuizen DE, Dean AM, Hartl DL. Metabolic flux and fitness. Genetics. 1987 Jan; 115(1):25-31.
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  287. Sawyer SA, Dykhuizen DE, DuBose RF, Green L, Mutangadura-Mhlanga T, Wolczyk DF, Hartl DL. Distribution and abundance of insertion sequences among natural isolates of Escherichia coli. Genetics. 1987 Jan; 115(1):51-63.
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  288. Jacobson JW, Medhora MM, Hartl DL. Molecular structure of a somatically unstable transposable element in Drosophila. Proc Natl Acad Sci U S A. 1986 Nov; 83(22):8684-8.
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  289. Hartl DL, Dean AM, Dykhuizen DE. The molecular biology of natural selection: reply to burton and place. Genetics. 1986 Nov; 114(3):1037-9.
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  290. Dean AM, Dykhuizen DE, Hartl DL. Fitness as a function of beta-galactosidase activity in Escherichia coli. Genet Res. 1986 Aug; 48(1):1-8.
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  291. Hartl DL, Medhora M, Green L, Dykhuizen DE. The evolution of DNA sequences in Escherichia coli. Philos Trans R Soc Lond B Biol Sci. 1986 Jan 29; 312(1154):191-204.
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  292. Hartl DL. Evolution and tinkering: the molecular genetics of bacterial adaption. Prog Clin Biol Res. 1986; 218:161-75.
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  293. Hartl DL, Dykhuizen DE, Dean AM. Limits of adaptation: the evolution of selective neutrality. Genetics. 1985 Nov; 111(3):655-74.
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  294. Routman E, Miller RD, Phillips-Conroy J, Hartl DL. Antibiotic resistance and population structure in Escherichia coli from free-ranging African yellow baboons. Appl Environ Microbiol. 1985 Oct; 50(4):749-54.
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  295. Dykhuizen DE, Sawyer SA, Green L, Miller RD, Hartl DL. Joint distribution of insertion elements IS4 and IS5 in natural isolates of Escherichia coli. Genetics. 1985 Oct; 111(2):219-31.
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  296. Jacobson JW, Hartl DL. Coupled instability of two X-linked genes in Drosophila mauritiana: germinal and somatic mutability. Genetics. 1985 Sep; 111(1):57-65.
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  297. Behlke MA, Spinella DG, Chou HS, Sha W, Hartl DL, Loh DY. T-cell receptor beta-chain expression: dependence on relatively few variable region genes. Science. 1985 Aug 9; 229(4713):566-70.
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  298. Miller RD, Dykhuizen DE, Green L, Hartl DL. Specific deletion occurring in the directed evolution of 6-phosphogluconate dehydrogenase in Escherichia coli. Genetics. 1984 Dec; 108(4):765-72.
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  299. Scavarda NJ, Hartl DL. Interspecific DNA transformation in Drosophila. Proc Natl Acad Sci U S A. 1984 Dec; 81(23):7515-9.
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  300. Green L, Miller RD, Dykhuizen DE, Hartl DL. Distribution of DNA insertion element IS5 in natural isolates of Escherichia coli. Proc Natl Acad Sci U S A. 1984 Jul; 81(14):4500-4.
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  301. Dykhuizen DE, de Framond J, Hartl DL. Potential for hitchhiking in the eda-edd-zwf gene cluster of Escherichia coli. Genet Res. 1984 Jun; 43(3):229-39.
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  302. Dykhuizen DE, de Framond J, Hartl DL. Selective neutrality of glucose-6-phosphate dehydrogenase allozymes in Escherichia coli. Mol Biol Evol. 1984 Feb; 1(2):162-70.
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  303. Hartl DL, Dykhuizen DE, Berg DE. Accessory DNAs in the bacterial gene pool: playground for coevolution. Ciba Found Symp. 1984; 102:233-45.
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  304. Hartl DL, Dykhuizen DE. The population genetics of Escherichia coli. Annu Rev Genet. 1984; 18:31-68.
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  305. Hartl DL, Dykhuizen DE, Miller RD, Green L, de Framond J. Transposable element IS50 improves growth rate of E. coli cells without transposition. Cell. 1983 Dec; 35(2 Pt 1):503-10.
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  306. Dykhuizen DE, Hartl DL. Functional effects of PGI allozymes in Escherichia coli. Genetics. 1983 Sep; 105(1):1-18.
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  307. Dykhuizen DE, Hartl DL. Selection in chemostats. Microbiol Rev. 1983 Jun; 47(2):150-68.
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  308. Haymer DS, Hartl DL. The Experimental Assessment of Fitness in Drosophila. II. a Comparison of Competitive and Noncompetitive Measures. Genetics. 1983 Jun; 104(2):343-52.
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  309. Biel SW, Hartl DL. Evolution of transposons: natural selection for Tn5 in Escherichia coli K12. Genetics. 1983 Apr; 103(4):581-92.
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  310. Haymer DS, Hartl DL. The experimental assessment of fitness in Drosophila. I. Comparative measures of competitive reproductive success. Genetics. 1982 Nov; 102(3):455-66.
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  311. Hartl DL, Campbell RB. Allele multiplicity in simple Mendelian disorders. Am J Hum Genet. 1982 Nov; 34(6):866-73.
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  312. Hauschteck-Jungen E, Hartl DL. Defective Histone Transition during Spermiogenesis in Heterozygous SEGREGATION DISTORTER Males of DROSOPHILA MELANOGASTER. Genetics. 1982 May; 101(1):57-69.
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  313. Hartl DL, Dykhuizen DE. Potential for selection among nearly neutral allozymes of 6-phosphogluconate dehydrogenase in Escherichia coli. Proc Natl Acad Sci U S A. 1981 Oct; 78(10):6344-8.
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  314. Dykhuizen D, Hartl DL. Selective neutrality of 6PGD allozymes in E. coli and the effects of genetic background. Genetics. 1980 Dec; 96(4):801-17.
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  315. Kettaneh NP, Hartl DL. Ultrastructural analysis of spermiogenesis in segregation distorter males of Drosophila melanogaster: the homozygotes. Genetics. 1980 Nov; 96(3):665-83.
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  316. Hartl DL. Genetic dissection of segregation distortion. III. Unequal recovery of reciprocal recombinants. Genetics. 1980 Nov; 96(3):685-96.
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  317. Charlesworth B, Hartl DL. Population Dynamics of the Segregation Distorter Polymorphism of DROSOPHILA MELANOGASTER. Genetics. 1978 May; 89(1):171-92.
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  318. Hauschteck-Jungen E, Hartl DL. DNA Distribution in Spermatid Nuclei of Normal and Segregation Distorter Males of DROSOPHILA MELANOGASTER. Genetics. 1978 May; 89(1):15-35.
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  319. Hartl DL. Mutation-selection balance with stochastic selection. Genetics. 1977 Jul; 86(3):687-96.
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  320. Hartl DL. Mechanism of a case of genetic coadaptation in populations of Drosophila melanogaster. Proc Natl Acad Sci U S A. 1977 Jan; 74(1):324-8.
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  321. Hartl DL. Stochastic selection in both haplophase and diplophase. J Math Biol. 1976 Nov 25; 3(3-4):263-9.
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  322. Kettaneh NP, Hartl DL. Histone transition during spermiogenesis is absent in segregation distorter males of Drosophila melanogaster. Science. 1976 Sep 10; 193(4257):1020-1.
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  323. Erickson J, Hartl DL. Cytogenetic analysis of homozygous segregation distorter males of Drosophila melanogaster. Can J Genet Cytol. 1976 Jun; 18(2):287-96.
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  324. Gall BG, Hartl DL. Regulation of newly evolved enzymes. II. The ebg repressor. Genetics. 1975 Nov; 81(3):427-35.
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  325. Hartl DL, Dempster ER, Brown SW. Adaptive significance of vegetative incompatibility in Neurospora crassa. Genetics. 1975 Nov; 81(3):553-69.
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  326. Hartl DL. Genetic dissection of segregation distortion II. Mechanism of suppression of distortion by certain inversions. Genetics. 1975 Jul; (3):539-47.
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  327. Hartl DL. Modifier theory and meiotic drive. Theor Popul Biol. 1975 Apr; 7(2):168-74.
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  328. Hartl DL, Hall BG. Second naturally occurring beta-galactosidase in E. coli. Nature. 1974 Mar 8; 248(444):152-3.
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  329. Hartl DL. Genetic dissection of segregation distortion. I. Suicide combinations of SD genes. Genetics. 1974 Mar; 76(3):477-86.
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  330. Hall BG, Hartl DL. Regulation of newly evolved enzymes. I. Selection of a novel lactase regulated by lactose in Escherichia coli. Genetics. 1974 Mar; 76(3):391-400.
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  331. Hartl DL. The Mechanism of a Brooding Effect Associated with Segregation Distortion in DROSOPHILA MELANOGASTER. Genetics. 1973 Aug; 74(4):619-31.
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  332. Hartl DL. Complementation analysis of male fertility among the segregation distorter chromosomes of Drosophila melanogaster. Genetics. 1973 Apr; 73(4):613-29.
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  333. Childress D, Hartl DL. Sperm preference in Drosophila melanogaster. Genetics. 1972 Jul; 71(3):417-27.
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  334. Hartl DL. Recurrence risks for germinal mosaics. Am J Hum Genet. 1971 Mar; 23(2):124-34.
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  335. Hartl DL. A mathematical model for recessive lethal segregation distorters with differential viabilities in the sexes. Genetics. 1970 Sep; 66(1):147-63.
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  336. Hartl DL. Meiotic drive in natural populations of Drosophila melanogaster. IX. Suppressors of segregation distorter in wild populations. Can J Genet Cytol. 1970 Sep; 12(3):594-600.
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  337. Hartl DL, Brown SW. The origin of male haploid genetic systems and their expected sex ratio. Theor Popul Biol. 1970 Aug; 1(2):165-90.
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  338. Hartl DL, Green MM. Genetic studies of germinal mosaicism in Drosophila melanogaster using the mutable wc gene. Genetics. 1970 Jul; 65(3):449-56.
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  339. Hartl DL. Dysfunctional sperm production in Drosophila melanogaster males homozygous for the segregation distorter elements. Proc Natl Acad Sci U S A. 1969 Jul; 63(3):782-9.
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  340. Hartl DL, Maruyama T. Phenogram enumeration: the number of regular genotype-phenotype correspondences in genetic systems. J Theor Biol. 1968 Aug; 20(2):129-63.
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  341. Hartl DL, Hiraizumi Y, Crow JF. Evidence for sperm dysfunction as the mechanism of segregation distortion in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1967 Dec; 58(6):2240-5.
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