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Keywords
Last Name
Institution

Alfred Lewis Goldberg, Ph.D.

TitleProfessor of Cell Biology
InstitutionHarvard Medical School
DepartmentCell Biology
AddressHarvard Medical School
Bldg. C-1, Rm. 415
240 Longwood Ave
Boston MA 02115
Phone617/432-1855
Fax617/432-1144

 Mentoring 
 current student opportunities
Available: 10/20/11, Expires: 06/30/15

The goal of these studies is to learn more about the cellular adaptations that lead to wasting of skeletal, as occurs upon disuse, denervation, fasting, cancer (cachexia) and aging. Several research projects are available, and the scope and precise question to be investigated will depend upon the student's interests and prior laboratory experience in biochemistry and cell or molecular biology. One major goal is to learn about the changes in gene transcription that are common to various types of atrophy and how this program is suppressed in hypertrophying muscle. A second opportunity would concern the biochemical mechanisms that catalyze the disassembly and degradation of components of the sarcomeric apparatus during atrophy (and its buildup during hypertrophy) in skeletal and cardiac muscle. The student(s) would do laboratory research in the Dept of Cell Biology under the supervision of Dr. Goldberg and a senior postdoctoral fellow (who has had prior teaching experience).

 completed student projects
Protein Degradation by Proteasomes from T. Acidophilum: Effects of mutations in the Opening to the Alpha-ring
Summer, 05/15/99 - 08/10/99
Role of the Chemical Chaperone Trehalose in the Near-freezing Stress Response of S. cerevisiae
Summer, 06/01/06 - 09/01/06
Implications of SODI Mutations in Familiar Amyotrophic Lateral Sclerosis
Part Time, 01/03/00 - 06/16/00

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Piccirillo R, Demontis F, Perrimon N, Goldberg AL. Mechanisms of muscle growth and atrophy in mammals and Drosophila. Dev Dyn. 2014 Feb; 243(2):201-15.
    View in: PubMed
  2. Demontis F, Piccirillo R, Goldberg AL, Perrimon N. Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech. 2013 Nov-Dec; 6(6):1339-52.
    View in: PubMed
  3. Sartori R, Schirwis E, Blaauw B, Bortolanza S, Zhao J, Enzo E, Stantzou A, Mouisel E, Toniolo L, Ferry A, Stricker S, Goldberg AL, Dupont S, Piccolo S, Amthor H, Sandri M. BMP signaling controls muscle mass. Nat Genet. 2013 Nov; 45(11):1309-18.
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  4. Lee D, Goldberg AL. SIRT1 Protein, by Blocking the Activities of Transcription Factors FoxO1 and FoxO3, Inhibits Muscle Atrophy and Promotes Muscle Growth. J Biol Chem. 2013 Oct 18; 288(42):30515-26.
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  5. Peth A, Nathan JA, Goldberg AL. The ATP costs and time required to degrade ubiquitinated proteins by the 26 s proteasome. J Biol Chem. 2013 Oct 4; 288(40):29215-22.
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  6. Demontis F, Piccirillo R, Goldberg AL, Perrimon N. The influence of skeletal muscle on systemic aging and lifespan. Aging Cell. 2013 Dec; 12(6):943-9.
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  7. Han HQ, Zhou X, Mitch WE, Goldberg AL. Myostatin/activin pathway antagonism: Molecular basis and therapeutic potential. Int J Biochem Cell Biol. 2013 Oct; 45(10):2333-47.
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  8. Qian MX, Pang Y, Liu CH, Haratake K, Du BY, Ji DY, Wang GF, Zhu QQ, Song W, Yu Y, Zhang XX, Huang HT, Miao S, Chen LB, Zhang ZH, Liang YN, Liu S, Cha H, Yang D, Zhai Y, Komatsu T, Tsuruta F, Li H, Cao C, Li W, Li GH, Cheng Y, Chiba T, Wang L, Goldberg AL, Shen Y, Qiu XB. Acetylation-Mediated Proteasomal Degradation of Core Histones during DNA Repair and Spermatogenesis. Cell. 2013 May 23; 153(5):1012-24.
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  9. Nathan JA, Spinnenhirn V, Schmidtke G, Basler M, Groettrup M, Goldberg AL. Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins. Cell. 2013 Feb 28; 152(5):1184-94.
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  10. Peth A, Kukushkin N, Bossé M, Goldberg AL. Ubiquitinated proteins activate the proteasomal ATPases by binding to usp14 or uch37 homologs. J Biol Chem. 2013 Mar 15; 288(11):7781-90.
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  11. Nathan JA, Tae Kim H, Ting L, Gygi SP, Goldberg AL. Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? EMBO J. 2013 Feb 20; 32(4):552-65.
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  12. Goldberg AL. Development of proteasome inhibitors as research tools and cancer drugs. J Cell Biol. 2012 Nov 12; 199(4):583-8.
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  13. Berko D, Tabachnick-Cherny S, Shental-Bechor D, Cascio P, Mioletti S, Levy Y, Admon A, Ziv T, Tirosh B, Goldberg AL, Navon A. The direction of protein entry into the proteasome determines the variety of products and depends on the force needed to unfold its two termini. Mol Cell. 2012 Nov 30; 48(4):601-11.
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  14. Raju RM, Goldberg AL, Rubin EJ. Bacterial proteolytic complexes as therapeutic targets. Nat Rev Drug Discov. 2012 Oct; 11(10):777-89.
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  15. Cohen S, Zhai B, Gygi SP, Goldberg AL. Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy. J Cell Biol. 2012 Aug 20; 198(4):575-89.
    View in: PubMed
  16. Nijhawan D, Zack TI, Ren Y, Strickland MR, Lamothe R, Schumacher SE, Tsherniak A, Besche HC, Rosenbluh J, Shehata S, Cowley GS, Weir BA, Goldberg AL, Mesirov JP, Root DE, Bhatia SN, Beroukhim R, Hahn WC. Cancer vulnerabilities unveiled by genomic loss. Cell. 2012 Aug 17; 150(4):842-54.
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  17. Piccirillo R, Goldberg AL. The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins. EMBO J. 2012 Aug 1; 31(15):3334-50.
    View in: PubMed
  18. Bhutani N, Piccirillo R, Hourez R, Venkatraman P, Goldberg AL. Cathepsins L and Z are critical in degrading polyglutamine-containing proteins within lysosomes. J Biol Chem. 2012 May 18; 287(21):17471-82.
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  19. Raju RM, Unnikrishnan M, Rubin DH, Krishnamoorthy V, Kandror O, Akopian TN, Goldberg AL, Rubin EJ. Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection. PLoS Pathog. 2012 Feb; 8(2):e1002511.
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  20. Akopian T, Kandror O, Raju RM, Unnikrishnan M, Rubin EJ, Goldberg AL. The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring. EMBO J. 2012 Mar 21; 31(6):1529-41.
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  21. Kim HT, Goldberg AL. Formation of nondegradable forked ubiquitin conjugates by ring-finger ligases and its prevention by S5a. Methods Mol Biol. 2012; 832:639-52.
    View in: PubMed
  22. Kim HT, Goldberg AL. S5a/Rpn10, a UIM-protein, as a universal substrate for ubiquitination. Methods Mol Biol. 2012; 832:653-60.
    View in: PubMed
  23. Besche HC, Goldberg AL. Affinity purification of mammalian 26S proteasomes using an ubiquitin-like domain. Methods Mol Biol. 2012; 832:423-32.
    View in: PubMed
  24. Sha Z, Peth A, Goldberg AL. Keeping proteasomes under control--a role for phosphorylation in the nucleus. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18573-4.
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  25. Dange T, Smith D, Noy T, Rommel PC, Jurzitza L, Cordero RJ, Legendre A, Finley D, Goldberg AL, Schmidt M. Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism. J Biol Chem. 2011 Dec 16; 286(50):42830-9.
    View in: PubMed
  26. Tofaris GK, Kim HT, Hourez R, Jung JW, Kim KP, Goldberg AL. Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17004-9.
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  27. Deriziotis P, André R, Smith DM, Goold R, Kinghorn KJ, Kristiansen M, Nathan JA, Rosenzweig R, Krutauz D, Glickman MH, Collinge J, Goldberg AL, Tabrizi SJ. Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry. EMBO J. 2011 Aug 3; 30(15):3065-77.
    View in: PubMed
  28. Lee D, Goldberg A. Atrogin1/MAFbx: what atrophy, hypertrophy, and cardiac failure have in common. Circ Res. 2011 Jul 8; 109(2):123-6.
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  29. Bader M, Benjamin S, Wapinski OL, Smith DM, Goldberg AL, Steller H. A conserved F box regulatory complex controls proteasome activity in Drosophila. Cell. 2011 Apr 29; 145(3):371-82.
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  30. Nguyen TT, Chang SC, Evnouchidou I, York IA, Zikos C, Rock KL, Goldberg AL, Stratikos E, Stern LJ. Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol. 2011 May; 18(5):604-13.
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  31. Smith DM, Fraga H, Reis C, Kafri G, Goldberg AL. ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle. Cell. 2011 Feb 18; 144(4):526-38.
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  32. Peth A, Uchiki T, Goldberg AL. ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation. Mol Cell. 2010 Nov 24; 40(4):671-81.
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  33. Altun M, Besche HC, Overkleeft HS, Piccirillo R, Edelmann MJ, Kessler BM, Goldberg AL, Ulfhake B. Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway. J Biol Chem. 2010 Dec 17; 285(51):39597-608.
    View in: PubMed
  34. Raffaello A, Milan G, Masiero E, Carnio S, Lee D, Lanfranchi G, Goldberg AL, Sandri M. JunB transcription factor maintains skeletal muscle mass and promotes hypertrophy. J Cell Biol. 2010 Oct 4; 191(1):101-13.
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  35. Menzies FM, Hourez R, Imarisio S, Raspe M, Sadiq O, Chandraratna D, O'Kane C, Rock KL, Reits E, Goldberg AL, Rubinsztein DC. Puromycin-sensitive aminopeptidase protects against aggregation-prone proteins via autophagy. Hum Mol Genet. 2010 Dec 1; 19(23):4573-86.
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  36. Zhou X, Wang JL, Lu J, Song Y, Kwak KS, Jiao Q, Rosenfeld R, Chen Q, Boone T, Simonet WS, Lacey DL, Goldberg AL, Han HQ. Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell. 2010 Aug 20; 142(4):531-43.
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  37. Tai HC, Besche H, Goldberg AL, Schuman EM. Characterization of the Brain 26S Proteasome and its Interacting Proteins. Front Mol Neurosci. 2010; 3.
    View in: PubMed
  38. Brault JJ, Jespersen JG, Goldberg AL. Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy. J Biol Chem. 2010 Jun 18; 285(25):19460-71.
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  39. Yu Y, Smith DM, Kim HM, Rodriguez V, Goldberg AL, Cheng Y. Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions. EMBO J. 2010 Feb 3; 29(3):692-702.
    View in: PubMed
  40. Peth A, Besche HC, Goldberg AL. Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening. Mol Cell. 2009 Dec 11; 36(5):794-804.
    View in: PubMed
  41. Lee do H, Goldberg AL. Hsp104 is essential for the selective degradation in yeast of polyglutamine expanded ataxin-1 but not most misfolded proteins generally. Biochem Biophys Res Commun. 2010 Jan 1; 391(1):1056-61.
    View in: PubMed
  42. Besche HC, Peth A, Goldberg AL. Getting to first base in proteasome assembly. Cell. 2009 Jul 10; 138(1):25-8.
    View in: PubMed
  43. Cohen S, Brault JJ, Gygi SP, Glass DJ, Valenzuela DM, Gartner C, Latres E, Goldberg AL. During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol. 2009 Jun 15; 185(6):1083-95.
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  44. Kim HT, Kim KP, Uchiki T, Gygi SP, Goldberg AL. S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains. EMBO J. 2009 Jul 8; 28(13):1867-77.
    View in: PubMed
  45. Besche HC, Haas W, Gygi SP, Goldberg AL. Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Biochemistry. 2009 Mar 24; 48(11):2538-49.
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  46. Uchiki T, Kim HT, Zhai B, Gygi SP, Johnston JA, O'Bryan JP, Goldberg AL. The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition. J Biol Chem. 2009 May 8; 284(19):12622-32.
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  47. Evnouchidou I, Momburg F, Papakyriakou A, Chroni A, Leondiadis L, Chang SC, Goldberg AL, Stratikos E. The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1. PLoS One. 2008; 3(11):e3658.
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  48. Medicherla B, Goldberg AL. Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins. J Cell Biol. 2008 Aug 25; 182(4):663-73.
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  49. Rabl J, Smith DM, Yu Y, Chang SC, Goldberg AL, Cheng Y. Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol Cell. 2008 May 9; 30(3):360-8.
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  50. Zhao J, Brault JJ, Schild A, Goldberg AL. Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor. Autophagy. 2008 Apr; 4(3):378-80.
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  51. Anderson SB, Goldberg AL, Whitman M. Identification of a novel pool of extracellular pro-myostatin in skeletal muscle. J Biol Chem. 2008 Mar 14; 283(11):7027-35.
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  52. Xu L, Zhu J, Hu X, Zhu H, Kim HT, LaBaer J, Goldberg A, Yuan J. c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. Mol Cell. 2007 Dec 14; 28(5):914-22.
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  53. Zhao J, Brault JJ, Schild A, Cao P, Sandri M, Schiaffino S, Lecker SH, Goldberg AL. FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab. 2007 Dec; 6(6):472-83.
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  54. Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, Del Piccolo P, Burden SJ, Di Lisi R, Sandri C, Zhao J, Goldberg AL, Schiaffino S, Sandri M. FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab. 2007 Dec; 6(6):458-71.
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  55. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clavé C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dröge W, Dron M, Dunn WA, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fésüs L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, González-Estévez C, Gorski S, Gottlieb RA, Häussinger D, He YW, Heidenreich K, Hill JA, Høyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jäättelä M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovács AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, López-Otín C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Meléndez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Münz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nürnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tallóczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcátegui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008 Feb; 4(2):151-75.
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  56. Liu CH, Goldberg AL, Qiu XB. New insights into the role of the ubiquitin-proteasome pathway in the regulation of apoptosis. Chang Gung Med J. 2007 Nov-Dec; 30(6):469-79.
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  57. Goldberg AL. On prions, proteasomes, and mad cows. N Engl J Med. 2007 Sep 13; 357(11):1150-2.
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  58. Smith DM, Chang SC, Park S, Finley D, Cheng Y, Goldberg AL. Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell. 2007 Sep 7; 27(5):731-44.
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  59. Horwitz AA, Navon A, Groll M, Smith DM, Reis C, Goldberg AL. ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in Archaea. J Biol Chem. 2007 Aug 3; 282(31):22921-9.
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  60. Kim HT, Kim KP, Lledias F, Kisselev AF, Scaglione KM, Skowyra D, Gygi SP, Goldberg AL. Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. J Biol Chem. 2007 Jun 15; 282(24):17375-86.
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  61. Bhutani N, Venkatraman P, Goldberg AL. Puromycin-sensitive aminopeptidase is the major peptidase responsible for digesting polyglutamine sequences released by proteasomes during protein degradation. EMBO J. 2007 Mar 7; 26(5):1385-96.
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  62. Goldberg AL. Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy. Biochem Soc Trans. 2007 Feb; 35(Pt 1):12-7.
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  63. Qiu XB, Ouyang SY, Li CJ, Miao S, Wang L, Goldberg AL. hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37. EMBO J. 2006 Dec 13; 25(24):5742-53.
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  64. Sacheck JM, Hyatt JP, Raffaello A, Jagoe RT, Roy RR, Edgerton VR, Lecker SH, Goldberg AL. Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases. FASEB J. 2007 Jan; 21(1):140-55.
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  65. Sandri M, Lin J, Handschin C, Yang W, Arany ZP, Lecker SH, Goldberg AL, Spiegelman BM. PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16260-5.
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  66. York IA, Bhutani N, Zendzian S, Goldberg AL, Rock KL. Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation. J Immunol. 2006 Aug 1; 177(3):1434-43.
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  67. Lecker SH, Goldberg AL, Mitch WE. Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol. 2006 Jul; 17(7):1807-19.
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  68. Smith DM, Benaroudj N, Goldberg A. Proteasomes and their associated ATPases: a destructive combination. J Struct Biol. 2006 Oct; 156(1):72-83.
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  69. Kisselev AF, Callard A, Goldberg AL. Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate. J Biol Chem. 2006 Mar 31; 281(13):8582-90.
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  70. Smith DM, Kafri G, Cheng Y, Ng D, Walz T, Goldberg AL. ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Mol Cell. 2005 Dec 9; 20(5):687-98.
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  71. Chang SC, Momburg F, Bhutani N, Goldberg AL. The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17107-12.
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  72. Skurk C, Izumiya Y, Maatz H, Razeghi P, Shiojima I, Sandri M, Sato K, Zeng L, Schiekofer S, Pimentel D, Lecker S, Taegtmeyer H, Goldberg AL, Walsh K. The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling. J Biol Chem. 2005 May 27; 280(21):20814-23.
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  73. Goldberg AL. Nobel committee tags ubiquitin for distinction. Neuron. 2005 Feb 3; 45(3):339-44.
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  74. Cascio P, Goldberg AL. Preparation of hybrid (19S-20S-PA28) proteasome complexes and analysis of peptides generated during protein degradation. Methods Enzymol. 2005; 398:336-52.
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  75. Kisselev AF, Goldberg AL. Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates. Methods Enzymol. 2005; 398:364-78.
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  76. Qiu XB, Goldberg AL. The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9. J Biol Chem. 2005 Jan 7; 280(1):174-82.
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  77. Saric T, Graef CI, Goldberg AL. Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases. J Biol Chem. 2004 Nov 5; 279(45):46723-32.
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  78. Rock KL, York IA, Goldberg AL. Post-proteasomal antigen processing for major histocompatibility complex class I presentation. Nat Immunol. 2004 Jul; 5(7):670-7.
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  79. Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH, Goldberg AL. Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell. 2004 Apr 30; 117(3):399-412.
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  80. Sacheck JM, Ohtsuka A, McLary SC, Goldberg AL. IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab. 2004 Oct; 287(4):E591-601.
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  81. Venkatraman P, Wetzel R, Tanaka M, Nukina N, Goldberg AL. Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. Mol Cell. 2004 Apr 9; 14(1):95-104.
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  82. Kandror O, Bretschneider N, Kreydin E, Cavalieri D, Goldberg AL. Yeast adapt to near-freezing temperatures by STRE/Msn2,4-dependent induction of trehalose synthesis and certain molecular chaperones. Mol Cell. 2004 Mar 26; 13(6):771-81.
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  83. Qiu XB, Markant SL, Yuan J, Goldberg AL. Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J. 2004 Feb 25; 23(4):800-10.
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  84. Lecker SH, Jagoe RT, Gilbert A, Gomes M, Baracos V, Bailey J, Price SR, Mitch WE, Goldberg AL. Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J. 2004 Jan; 18(1):39-51.
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  85. Goldberg AL. Protein degradation and protection against misfolded or damaged proteins. Nature. 2003 Dec 18; 426(6968):895-9.
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  86. Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, Ploegh HL, Thornberry NA, Goldberg AL. The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. J Biol Chem. 2003 Sep 19; 278(38):35869-77.
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  87. Li YP, Lecker SH, Chen Y, Waddell ID, Goldberg AL, Reid MB. TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k. FASEB J. 2003 Jun; 17(9):1048-57.
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  88. York IA, Mo AX, Lemerise K, Zeng W, Shen Y, Abraham CR, Saric T, Goldberg AL, Rock KL. The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity. 2003 Mar; 18(3):429-40.
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  89. Benaroudj N, Zwickl P, Seemüller E, Baumeister W, Goldberg AL. ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation. Mol Cell. 2003 Jan; 11(1):69-78.
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  90. Lecker SH, Goldberg AL. Slowing muscle atrophy: putting the brakes on protein breakdown. J Physiol. 2002 Dec 15; 545(Pt 3):729.
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  91. York IA, Chang SC, Saric T, Keys JA, Favreau JM, Goldberg AL, Rock KL. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol. 2002 Dec; 3(12):1177-84.
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  92. Saric T, Chang SC, Hattori A, York IA, Markant S, Rock KL, Tsujimoto M, Goldberg AL. An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol. 2002 Dec; 3(12):1169-76.
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  93. Jagoe RT, Lecker SH, Gomes M, Goldberg AL. Patterns of gene expression in atrophying skeletal muscles: response to food deprivation. FASEB J. 2002 Nov; 16(13):1697-712.
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  94. Qiu XB, Goldberg AL. Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14843-8.
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  95. Goldberg AL, Cascio P, Saric T, Rock KL. The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides. Mol Immunol. 2002 Oct; 39(3-4):147-64.
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  96. Kandror O, DeLeon A, Goldberg AL. Trehalose synthesis is induced upon exposure of Escherichia coli to cold and is essential for viability at low temperatures. Proc Natl Acad Sci U S A. 2002 Jul 23; 99(15):9727-32.
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  97. Cascio P, Call M, Petre BM, Walz T, Goldberg AL. Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes. EMBO J. 2002 Jun 3; 21(11):2636-45.
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  98. Goldberg AL, Rock K. Not just research tools--proteasome inhibitors offer therapeutic promise. Nat Med. 2002 Apr; 8(4):338-40.
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  99. Kisselev AF, Kaganovich D, Goldberg AL. Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings. J Biol Chem. 2002 Jun 21; 277(25):22260-70.
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  100. Rock KL, York IA, Saric T, Goldberg AL. Protein degradation and the generation of MHC class I-presented peptides. Adv Immunol. 2002; 80:1-70.
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  101. Navon A, Goldberg AL. Proteins are unfolded on the surface of the ATPase ring before transport into the proteasome. Mol Cell. 2001 Dec; 8(6):1339-49.
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  102. Gomes MD, Lecker SH, Jagoe RT, Navon A, Goldberg AL. Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy. Proc Natl Acad Sci U S A. 2001 Dec 4; 98(25):14440-5.
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  103. Kisselev AF, Goldberg AL. Proteasome inhibitors: from research tools to drug candidates. Chem Biol. 2001 Aug; 8(8):739-58.
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  104. Saric T, Beninga J, Graef CI, Akopian TN, Rock KL, Goldberg AL. Major histocompatibility complex class I-presented antigenic peptides are degraded in cytosolic extracts primarily by thimet oligopeptidase. J Biol Chem. 2001 Sep 28; 276(39):36474-81.
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  105. Köhler A, Cascio P, Leggett DS, Woo KM, Goldberg AL, Finley D. The axial channel of the proteasome core particle is gated by the Rpt2 ATPase and controls both substrate entry and product release. Mol Cell. 2001 Jun; 7(6):1143-52.
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  106. Cascio P, Hilton C, Kisselev AF, Rock KL, Goldberg AL. 26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide. EMBO J. 2001 May 15; 20(10):2357-66.
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  107. Jagoe RT, Goldberg AL. What do we really know about the ubiquitin-proteasome pathway in muscle atrophy? Curr Opin Clin Nutr Metab Care. 2001 May; 4(3):183-90.
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  108. Benaroudj N, Lee DH, Goldberg AL. Trehalose accumulation during cellular stress protects cells and cellular proteins from damage by oxygen radicals. J Biol Chem. 2001 Jun 29; 276(26):24261-7.
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  109. Benaroudj N, Tarcsa E, Cascio P, Goldberg AL. The unfolding of substrates and ubiquitin-independent protein degradation by proteasomes. Biochimie. 2001 Mar-Apr; 83(3-4):311-8.
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  110. Goldberg AL, Elledge SJ, Harper JW. The cellular chamber of doom. Sci Am. 2001 Jan; 284(1):68-73.
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  111. Sherman MY, Goldberg AL. Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron. 2001 Jan; 29(1):15-32.
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  112. Huang HC, Sherman MY, Kandror O, Goldberg AL. The molecular chaperone DnaJ is required for the degradation of a soluble abnormal protein in Escherichia coli. J Biol Chem. 2001 Feb 9; 276(6):3920-8.
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  113. Benaroudj N, Goldberg AL. PAN, the proteasome-activating nucleotidase from archaebacteria, is a protein-unfolding molecular chaperone. Nat Cell Biol. 2000 Nov; 2(11):833-9.
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  114. Gao Y, Lecker S, Post MJ, Hietaranta AJ, Li J, Volk R, Li M, Sato K, Saluja AK, Steer ML, Goldberg AL, Simons M. Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide. J Clin Invest. 2000 Aug; 106(3):439-48.
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  115. Tarcsa E, Szymanska G, Lecker S, O'Connor CM, Goldberg AL. Ca2+-free calmodulin and calmodulin damaged by in vitro aging are selectively degraded by 26 S proteasomes without ubiquitination. J Biol Chem. 2000 Jul 7; 275(27):20295-301.
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  116. Kisselev AF, Songyang Z, Goldberg AL. Why does threonine, and not serine, function as the active site nucleophile in proteasomes? J Biol Chem. 2000 May 19; 275(20):14831-7.
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  117. Goldberg AL. Probing the proteasome pathway. Nat Biotechnol. 2000 May; 18(5):494-6.
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  118. Daffner RH, Brown RR, Goldberg AL. A new classification for cervical vertebral injuries: influence of CT. Skeletal Radiol. 2000 Mar; 29(3):125-32.
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  119. Dagirmanjian A, Davis DA, Rothfus WE, Goldberg AL, Deeb ZL. Detection of clinically silent intracranial emboli ipsilateral to internal carotid occlusions during cerebral angiography. AJR Am J Roentgenol. 2000 Feb; 174(2):367-9.
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  120. York IA, Goldberg AL, Mo XY, Rock KL. Proteolysis and class I major histocompatibility complex antigen presentation. Immunol Rev. 1999 Dec; 172:49-66.
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  121. Mo XY, Cascio P, Lemerise K, Goldberg AL, Rock K. Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides. J Immunol. 1999 Dec 1; 163(11):5851-9.
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  122. Lecker SH, Solomon V, Price SR, Kwon YT, Mitch WE, Goldberg AL. Ubiquitin conjugation by the N-end rule pathway and mRNAs for its components increase in muscles of diabetic rats. J Clin Invest. 1999 Nov; 104(10):1411-20.
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  123. Zwickl P, Ng D, Woo KM, Klenk HP, Goldberg AL. An archaebacterial ATPase, homologous to ATPases in the eukaryotic 26 S proteasome, activates protein breakdown by 20 S proteasomes. J Biol Chem. 1999 Sep 10; 274(37):26008-14.
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  124. Kisselev AF, Akopian TN, Castillo V, Goldberg AL. Proteasome active sites allosterically regulate each other, suggesting a cyclical bite-chew mechanism for protein breakdown. Mol Cell. 1999 Sep; 4(3):395-402.
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  125. Hu Z, Zhang Z, Doo E, Coux O, Goldberg AL, Liang TJ. Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex. J Virol. 1999 Sep; 73(9):7231-40.
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  126. Lazarus DD, Destree AT, Mazzola LM, McCormack TA, Dick LR, Xu B, Huang JQ, Pierce JW, Read MA, Coggins MB, Solomon V, Goldberg AL, Brand SJ, Elliott PJ. A new model of cancer cachexia: contribution of the ubiquitin-proteasome pathway. Am J Physiol. 1999 Aug; 277(2 Pt 1):E332-41.
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  127. Kisselev AF, Akopian TN, Woo KM, Goldberg AL. The sizes of peptides generated from protein by mammalian 26 and 20 S proteasomes. Implications for understanding the degradative mechanism and antigen presentation. J Biol Chem. 1999 Feb 5; 274(6):3363-71.
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  128. Lecker SH, Solomon V, Mitch WE, Goldberg AL. Muscle protein breakdown and the critical role of the ubiquitin-proteasome pathway in normal and disease states. J Nutr. 1999 Jan; 129(1S Suppl):227S-237S.
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  129. Chain DG, Casadio A, Schacher S, Hegde AN, Valbrun M, Yamamoto N, Goldberg AL, Bartsch D, Kandel ER, Schwartz JH. Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia. Neuron. 1999 Jan; 22(1):147-56.
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  130. Rock KL, Goldberg AL. Degradation of cell proteins and the generation of MHC class I-presented peptides. Annu Rev Immunol. 1999; 17:739-79.
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  131. Solomon V, Baracos V, Sarraf P, Goldberg AL. Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12602-7.
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  132. Lee DH, Goldberg AL. Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol. 1998 Oct; 8(10):397-403.
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  133. Solomon V, Lecker SH, Goldberg AL. The N-end rule pathway catalyzes a major fraction of the protein degradation in skeletal muscle. J Biol Chem. 1998 Sep 25; 273(39):25216-22.
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  134. Beninga J, Rock KL, Goldberg AL. Interferon-gamma can stimulate post-proteasomal trimming of the N terminus of an antigenic peptide by inducing leucine aminopeptidase. J Biol Chem. 1998 Jul 24; 273(30):18734-42.
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  135. Coux O, Goldberg AL. Enzymes catalyzing ubiquitination and proteolytic processing of the p105 precursor of nuclear factor kappaB1. J Biol Chem. 1998 Apr 10; 273(15):8820-8.
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  136. Kisselev AF, Akopian TN, Goldberg AL. Range of sizes of peptide products generated during degradation of different proteins by archaeal proteasomes. J Biol Chem. 1998 Jan 23; 273(4):1982-9.
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  137. Lee DH, Goldberg AL. Proteasome inhibitors cause induction of heat shock proteins and trehalose, which together confer thermotolerance in Saccharomyces cerevisiae. Mol Cell Biol. 1998 Jan; 18(1):30-8.
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  138. Adams GM, Falke S, Goldberg AL, Slaughter CA, DeMartino GN, Gogol EP. Structural and functional effects of PA700 and modulator protein on proteasomes. J Mol Biol. 1997 Oct 31; 273(3):646-57.
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  139. Huang H, Goldberg AL. Proteolytic activity of the ATP-dependent protease HslVU can be uncoupled from ATP hydrolysis. J Biol Chem. 1997 Aug 22; 272(34):21364-72.
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  140. Fisher EA, Zhou M, Mitchell DM, Wu X, Omura S, Wang H, Goldberg AL, Ginsberg HN. The degradation of apolipoprotein B100 is mediated by the ubiquitin-proteasome pathway and involves heat shock protein 70. J Biol Chem. 1997 Aug 15; 272(33):20427-34.
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  141. Seol JH, Yoo SJ, Shin DH, Shim YK, Kang MS, Goldberg AL, Chung CH. The heat-shock protein HslVU from Escherichia coli is a protein-activated ATPase as well as an ATP-dependent proteinase. Eur J Biochem. 1997 Aug 1; 247(3):1143-50.
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  142. Tawa NE, Odessey R, Goldberg AL. Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles. J Clin Invest. 1997 Jul 1; 100(1):197-203.
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  143. Bogyo M, McMaster JS, Gaczynska M, Tortorella D, Goldberg AL, Ploegh H. Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6629-34.
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  144. Craiu A, Gaczynska M, Akopian T, Gramm CF, Fenteany G, Goldberg AL, Rock KL. Lactacystin and clasto-lactacystin beta-lactone modify multiple proteasome beta-subunits and inhibit intracellular protein degradation and major histocompatibility complex class I antigen presentation. J Biol Chem. 1997 May 16; 272(20):13437-45.
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  145. Kandror O, Goldberg AL. Trigger factor is induced upon cold shock and enhances viability of Escherichia coli at low temperatures. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):4978-81.
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  146. Bush KT, Goldberg AL, Nigam SK. Proteasome inhibition leads to a heat-shock response, induction of endoplasmic reticulum chaperones, and thermotolerance. J Biol Chem. 1997 Apr 4; 272(14):9086-92.
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  147. Goldberg AL, Akopian TN, Kisselev AF, Lee DH, Rohrwild M. New insights into the mechanisms and importance of the proteasome in intracellular protein degradation. Biol Chem. 1997 Mar-Apr; 378(3-4):131-40.
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  148. Goldberg AL, Akopian TN, Kisselev AF, Lee DH. Protein degradation by the proteasome and dissection of its in vivo importance with synthetic inhibitors. Mol Biol Rep. 1997 Mar; 24(1-2):69-75.
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  149. Rohrwild M, Pfeifer G, Santarius U, Müller SA, Huang HC, Engel A, Baumeister W, Goldberg AL. The ATP-dependent HslVU protease from Escherichia coli is a four-ring structure resembling the proteasome. Nat Struct Biol. 1997 Feb; 4(2):133-9.
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  150. Akopian TN, Kisselev AF, Goldberg AL. Processive degradation of proteins and other catalytic properties of the proteasome from Thermoplasma acidophilum. J Biol Chem. 1997 Jan 17; 272(3):1791-8.
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  151. Kandror O, Sherman M, Moerschell R, Goldberg AL. Trigger factor associates with GroEL in vivo and promotes its binding to certain polypeptides. J Biol Chem. 1997 Jan 17; 272(3):1730-4.
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  152. Mitch WE, Goldberg AL. Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway. N Engl J Med. 1996 Dec 19; 335(25):1897-905.
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  153. Lee DH, Goldberg AL. Selective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae. J Biol Chem. 1996 Nov 1; 271(44):27280-4.
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  154. Solomon V, Goldberg AL. Importance of the ATP-ubiquitin-proteasome pathway in the degradation of soluble and myofibrillar proteins in rabbit muscle extracts. J Biol Chem. 1996 Oct 25; 271(43):26690-7.
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  155. Lee DH, Sherman MY, Goldberg AL. Involvement of the molecular chaperone Ydj1 in the ubiquitin-dependent degradation of short-lived and abnormal proteins in Saccharomyces cerevisiae. Mol Cell Biol. 1996 Sep; 16(9):4773-81.
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  156. Pepato MT, Migliorini RH, Goldberg AL, Kettelhut IC. Role of different proteolytic pathways in degradation of muscle protein from streptozotocin-diabetic rats. Am J Physiol. 1996 Aug; 271(2 Pt 1):E340-7.
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  157. Grimm LM, Goldberg AL, Poirier GG, Schwartz LM, Osborne BA. Proteasomes play an essential role in thymocyte apoptosis. EMBO J. 1996 Aug 1; 15(15):3835-44.
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  158. Gaczynska M, Goldberg AL, Tanaka K, Hendil KB, Rock KL. Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7. J Biol Chem. 1996 Jul 19; 271(29):17275-80.
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  159. Yaglom JA, Goldberg AL, Finley D, Sherman MY. The molecular chaperone Ydj1 is required for the p34CDC28-dependent phosphorylation of the cyclin Cln3 that signals its degradation. Mol Cell Biol. 1996 Jul; 16(7):3679-84.
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  160. Yoo SJ, Seol JH, Shin DH, Rohrwild M, Kang MS, Tanaka K, Goldberg AL, Chung CH. Purification and characterization of the heat shock proteins HslV and HslU that form a new ATP-dependent protease in Escherichia coli. J Biol Chem. 1996 Jun 14; 271(24):14035-40.
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  161. Rohrwild M, Coux O, Huang HC, Moerschell RP, Yoo SJ, Seol JH, Chung CH, Goldberg AL. HslV-HslU: A novel ATP-dependent protease complex in Escherichia coli related to the eukaryotic proteasome. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):5808-13.
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  162. Kania MA, Demartino GN, Baumeister W, Goldberg AL. The proteasome subunit, C2, contains an important site for binding of the PA28 (11S) activator. Eur J Biochem. 1996 Mar 1; 236(2):510-6.
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  163. Rubin DM, Coux O, Wefes I, Hengartner C, Young RA, Goldberg AL, Finley D. Identification of the gal4 suppressor Sug1 as a subunit of the yeast 26S proteasome. Nature. 1996 Feb 15; 379(6566):655-7.
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  164. Coux O, Tanaka K, Goldberg AL. Structure and functions of the 20S and 26S proteasomes. Annu Rev Biochem. 1996; 65:801-47.
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  165. Sherman MY, Goldberg AL. Involvement of molecular chaperones in intracellular protein breakdown. EXS. 1996; 77:57-78.
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  166. Kim KI, Baek SH, Hong YM, Kang MS, Ha DB, Goldberg AL, Chung CH. Purification and characterization of protease Ci, a cytoplasmic metalloendoprotease in Escherichia coli. J Biol Chem. 1995 Dec 15; 270(50):29799-805.
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  167. Kandror O, Sherman M, Rhode M, Goldberg AL. Trigger factor is involved in GroEL-dependent protein degradation in Escherichia coli and promotes binding of GroEL to unfolded proteins. EMBO J. 1995 Dec 1; 14(23):6021-7.
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  168. Grant EP, Michalek MT, Goldberg AL, Rock KL. Rate of antigen degradation by the ubiquitin-proteasome pathway influences MHC class I presentation. J Immunol. 1995 Oct 15; 155(8):3750-8.
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  169. Jensen TJ, Loo MA, Pind S, Williams DB, Goldberg AL, Riordan JR. Multiple proteolytic systems, including the proteasome, contribute to CFTR processing. Cell. 1995 Oct 6; 83(1):129-35.
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  170. Goldberg AL, Stein R, Adams J. New insights into proteasome function: from archaebacteria to drug development. Chem Biol. 1995 Aug; 2(8):503-8.
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  171. Medina R, Wing SS, Goldberg AL. Increase in levels of polyubiquitin and proteasome mRNA in skeletal muscle during starvation and denervation atrophy. Biochem J. 1995 May 1; 307 ( Pt 3):631-7.
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  172. Baracos VE, DeVivo C, Hoyle DH, Goldberg AL. Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma. Am J Physiol. 1995 May; 268(5 Pt 1):E996-1006.
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  173. Wing SS, Haas AL, Goldberg AL. Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation. Biochem J. 1995 May 1; 307 ( Pt 3):639-45.
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  174. Goldberg AL. Functions of the proteasome: the lysis at the end of the tunnel. Science. 1995 Apr 28; 268(5210):522-3.
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  175. Lah TT, Hawley M, Rock KL, Goldberg AL. Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages. FEBS Lett. 1995 Apr 17; 363(1-2):85-9.
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  176. Goldberg AL, Gaczynska M, Grant E, Michalek M, Rock KL. Functions of the proteasome in antigen presentation. Cold Spring Harb Symp Quant Biol. 1995; 60:479-90.
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  177. Sherman M, Goldberg AL. Heat shock-induced phosphorylation of GroEL alters its binding and dissociation from unfolded proteins. J Biol Chem. 1994 Dec 16; 269(50):31479-83.
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  178. Van Kaer L, Ashton-Rickardt PG, Eichelberger M, Gaczynska M, Nagashima K, Rock KL, Goldberg AL, Doherty PC, Tonegawa S. Altered peptidase and viral-specific T cell response in LMP2 mutant mice. Immunity. 1994 Oct; 1(7):533-41.
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  179. Gaczynska M, Rock KL, Spies T, Goldberg AL. Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9213-7.
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  180. Kandror O, Busconi L, Sherman M, Goldberg AL. Rapid degradation of an abnormal protein in Escherichia coli involves the chaperones GroEL and GroES. J Biol Chem. 1994 Sep 23; 269(38):23575-82.
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  181. Palombella VJ, Rando OJ, Goldberg AL, Maniatis T. The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell. 1994 Sep 9; 78(5):773-85.
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  182. Rock KL, Gramm C, Rothstein L, Clark K, Stein R, Dick L, Hwang D, Goldberg AL. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell. 1994 Sep 9; 78(5):761-71.
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  183. Mitch WE, Medina R, Grieber S, May RC, England BK, Price SR, Bailey JL, Goldberg AL. Metabolic acidosis stimulates muscle protein degradation by activating the adenosine triphosphate-dependent pathway involving ubiquitin and proteasomes. J Clin Invest. 1994 May; 93(5):2127-33.
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  184. Kettelhut IC, Pepato MT, Migliorini RH, Medina R, Goldberg AL. Regulation of different proteolytic pathways in skeletal muscle in fasting and diabetes mellitus. Braz J Med Biol Res. 1994 Apr; 27(4):981-93.
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  185. Nigam SK, Goldberg AL, Ho S, Rohde MF, Bush KT. A set of endoplasmic reticulum proteins possessing properties of molecular chaperones includes Ca(2+)-binding proteins and members of the thioredoxin superfamily. J Biol Chem. 1994 Jan 21; 269(3):1744-9.
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  186. Goldberg AL, Moerschell RP, Chung CH, Maurizi MR. ATP-dependent protease La (lon) from Escherichia coli. Methods Enzymol. 1994; 244:350-75.
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  187. Kuzela S, Goldberg AL. Mitochondrial ATP-dependent protease from rat liver and yeast. Methods Enzymol. 1994; 244:376-83.
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  188. Sawada H, Muto K, Fujimuro M, Akaishi T, Sawada MT, Yokosawa H, Goldberg AL. Different ratios in 20 S proteasomes and regulatory subunit complexes in two isoforms of the 26 S proteasome purified from rabbit skeletal muscle. FEBS Lett. 1993 Dec 6; 335(2):207-12.
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  189. Dagirmanjian A, Davis DA, Rothfus WE, Deeb ZL, Goldberg AL. Silent cerebral microemboli occurring during carotid angiography: frequency as determined with Doppler sonography. AJR Am J Roentgenol. 1993 Nov; 161(5):1037-40.
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  190. Gaczynska M, Rock KL, Goldberg AL. Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes. Nature. 1993 Sep 16; 365(6443):264-7.
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  191. Sherman MY, Goldberg AL. Heat shock of Escherichia coli increases binding of dnaK (the hsp70 homolog) to polypeptides by promoting its phosphorylation. Proc Natl Acad Sci U S A. 1993 Sep 15; 90(18):8648-52.
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  192. Hegde AN, Goldberg AL, Schwartz JH. Regulatory subunits of cAMP-dependent protein kinases are degraded after conjugation to ubiquitin: a molecular mechanism underlying long-term synaptic plasticity. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7436-40.
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  193. Michalek MT, Grant EP, Gramm C, Goldberg AL, Rock KL. A role for the ubiquitin-dependent proteolytic pathway in MHC class I-restricted antigen presentation. Nature. 1993 Jun 10; 363(6429):552-4.
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  194. Wing SS, Goldberg AL. Glucocorticoids activate the ATP-ubiquitin-dependent proteolytic system in skeletal muscle during fasting. Am J Physiol. 1993 Apr; 264(4 Pt 1):E668-76.
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  195. Goldberg AL, Keaton NL, Rothfus WE, Daffner RH. Ankylosing spondylitis complicated by trauma: MR findings correlated with plain radiographs and CT. Skeletal Radiol. 1993; 22(5):333-6.
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  196. Gaczynska M, Rock KL, Goldberg AL. Role of proteasomes in antigen presentation. Enzyme Protein. 1993; 47(4-6):354-69.
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  197. Woo KM, Kim KI, Goldberg AL, Ha DB, Chung CH. The heat-shock protein ClpB in Escherichia coli is a protein-activated ATPase. J Biol Chem. 1992 Oct 5; 267(28):20429-34.
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  198. Tawa NE, Goldberg AL. Suppression of muscle protein turnover and amino acid degradation by dietary protein deficiency. Am J Physiol. 1992 Aug; 263(2 Pt 1):E317-25.
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  199. Tawa NE, Kettelhut IC, Goldberg AL. Dietary protein deficiency reduces lysosomal and nonlysosomal ATP-dependent proteolysis in muscle. Am J Physiol. 1992 Aug; 263(2 Pt 1):E326-34.
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  200. Goldberg AL, Rock KL. Proteolysis, proteasomes and antigen presentation. Nature. 1992 Jun 4; 357(6377):375-9.
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  201. Driscoll J, Frydman J, Goldberg AL. An ATP-stabilized inhibitor of the proteasome is a component of the 1500-kDa ubiquitin conjugate-degrading complex. Proc Natl Acad Sci U S A. 1992 Jun 1; 89(11):4986-90.
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  202. Heat shock in Escherichia coli alters the protein-binding properties of the chaperonin groEL by inducing its phosphorylation. Nature. 1992 May 14; 357(6374):167-9.
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  203. Goldberg AL. The mechanism and functions of ATP-dependent proteases in bacterial and animal cells. Eur J Biochem. 1992 Jan 15; 203(1-2):9-23.
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  204. Goldberg AL. Involvement of the chaperonin dnaK in the rapid degradation of a mutant protein in Escherichia coli. EMBO J. 1992 Jan; 11(1):71-7.
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  205. Sherman MY, Goldberg AL. Formation in vitro of complexes between an abnormal fusion protein and the heat shock proteins from Escherichia coli and yeast mitochondria. J Bacteriol. 1991 Nov; 173(22):7249-56.
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  206. Wing SS, Chiang HL, Goldberg AL, Dice JF. Proteins containing peptide sequences related to Lys-Phe-Glu-Arg-Gln are selectively depleted in liver and heart, but not skeletal muscle, of fasted rats. Biochem J. 1991 Apr 1; 275 ( Pt 1):165-9.
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  207. Goldberg AL, Baron B, Daffner RH. Atlantooccipital dislocation: MR demonstration of cord damage. J Comput Assist Tomogr. 1991 Jan-Feb; 15(1):174-5.
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  208. Goldberg AL, Soo MS, Deeb ZL, Rothfus WE. Degenerative disease of the lumbar spine. Role of CT-myelography in the MR era. Clin Imaging. 1991 Jan-Mar; 15(1):47-55.
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  209. Medina R, Wing SS, Haas A, Goldberg AL. Activation of the ubiquitin-ATP-dependent proteolytic system in skeletal muscle during fasting and denervation atrophy. Biomed Biochim Acta. 1991; 50(4-6):347-56.
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  210. Goldberg AL. ATP-dependent proteases in prokaryotic and eukaryotic cells. Semin Cell Biol. 1990 Dec; 1(6):423-32.
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  211. Rothfus WE, Goldberg AL, Deeb ZL, Daffner RH. MR recognition of posterior lumbar vertebral ring fracture. J Comput Assist Tomogr. 1990 Sep-Oct; 14(5):790-4.
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  212. Wilberger JE, Rothfus WE, Tabas J, Goldberg AL, Deeb ZL. Acute tissue tear hemorrhages of the brain: computed tomography and clinicopathological correlations. Neurosurgery. 1990 Aug; 27(2):208-13.
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  213. Furuno K, Goodman MN, Goldberg AL. Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy. J Biol Chem. 1990 May 25; 265(15):8550-7.
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  214. Deeb ZL, Rothfus WE, Goldberg AL, Daffner RH. Absent cord sign in acute spinal trauma. Clin Imaging. 1990 May; 14(2):138-42.
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  215. Driscoll J, Goldberg AL. The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins. J Biol Chem. 1990 Mar 25; 265(9):4789-92.
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  216. Goldberg AL, Daffner RH, Schapiro RL. Imaging of acute spinal trauma: an evolving multi-modality approach. Clin Imaging. 1990 Mar; 14(1):11-6.
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  217. Daffner RH, Deeb ZL, Goldberg AL, Kandabarow A, Rothfus WE. The radiologic assessment of post-traumatic vertebral stability. Skeletal Radiol. 1990; 19(2):103-8.
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  218. Matthews W, Driscoll J, Tanaka K, Ichihara A, Goldberg AL. Involvement of the proteasome in various degradative processes in mammalian cells. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2597-601.
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  219. Baron B, Goldberg AL, Rothfus WE, Sherman RL. CT features of sarcoid infiltration of a lumbosacral nerve root. J Comput Assist Tomogr. 1989 Mar-Apr; 13(2):364-5.
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  220. Woo KM, Chung WJ, Ha DB, Goldberg AL, Chung CH. Protease Ti from Escherichia coli requires ATP hydrolysis for protein breakdown but not for hydrolysis of small peptides. J Biol Chem. 1989 Feb 5; 264(4):2088-91.
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  221. Driscoll J, Goldberg AL. Skeletal muscle proteasome can degrade proteins in an ATP-dependent process that does not require ubiquitin. Proc Natl Acad Sci U S A. 1989 Feb; 86(3):787-91.
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  222. Goldberg AL, Rothfus WE, Deeb ZL, Frankel DG, Wilberger JE, Daffner RH. Hyperextension injuries of the cervical spine. Magnetic resonance findings. Skeletal Radiol. 1989; 18(4):283-8.
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  223. Kettelhut IC, Wing SS, Goldberg AL. Endocrine regulation of protein breakdown in skeletal muscle. Diabetes Metab Rev. 1988 Dec; 4(8):751-72.
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  224. Deeb ZL, Rothfus WE, Goldberg AL, Daffner RH. Occult occipital condyle fractures presenting as tumors. J Comput Tomogr. 1988 Oct; 12(4):261-3.
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  225. Shearer JE, Goldberg AL, Lupetin AR, Rothfus WE. Chondrosarcoma of the larynx. Report of a case with characteristic computed tomography findings. J Comput Tomogr. 1988 Oct; 12(4):292-4.
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  226. Chin DT, Goff SA, Webster T, Smith T, Goldberg AL. Sequence of the lon gene in Escherichia coli. A heat-shock gene which encodes the ATP-dependent protease La. J Biol Chem. 1988 Aug 25; 263(24):11718-28.
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  227. Kee Y, Lee YS, Chung CH, Waxman L, Goldberg AL. Improved methods for purification and assay of glycerol kinase from Escherichia coli. J Chromatogr. 1988 Jul 15; 428(2):345-51.
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  228. Hanley DF, Feldman E, Borel CO, Rosenbaum AE, Goldberg AL. Treatment of sagittal sinus thrombosis associated with cerebral hemorrhage and intracranial hypertension. Stroke. 1988 Jul; 19(7):903-9.
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  229. Hwang BJ, Woo KM, Goldberg AL, Chung CH. Protease Ti, a new ATP-dependent protease in Escherichia coli, contains protein-activated ATPase and proteolytic functions in distinct subunits. J Biol Chem. 1988 Jun 25; 263(18):8727-34.
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  230. Lee YS, Park SC, Goldberg AL, Chung CH. Protease So from Escherichia coli preferentially degrades oxidatively damaged glutamine synthetase. J Biol Chem. 1988 May 15; 263(14):6643-6.
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  231. Goldberg AL, Kettelhut IC, Furuno K, Fagan JM, Baracos V. Activation of protein breakdown and prostaglandin E2 production in rat skeletal muscle in fever is signaled by a macrophage product distinct from interleukin 1 or other known monokines. J Clin Invest. 1988 May; 81(5):1378-83.
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  232. Kettelhut IC, Goldberg AL. Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue. J Clin Invest. 1988 May; 81(5):1384-9.
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  233. Park JH, Lee YS, Chung CH, Goldberg AL. Purification and characterization of protease Re, a cytoplasmic endoprotease in Escherichia coli. J Bacteriol. 1988 Feb; 170(2):921-6.
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  234. Arrigo AP, Tanaka K, Goldberg AL, Welch WJ. Identity of the 19S 'prosome' particle with the large multifunctional protease complex of mammalian cells (the proteasome). Nature. 1988 Jan 14; 331(6152):192-4.
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  235. Goldberg AL, Rothfus WE, Deeb ZL, Khoury MB, Daffner RH. Thoracic disc herniation versus spinal metastases: optimizing diagnosis with magnetic resonance imaging. Skeletal Radiol. 1988; 17(6):423-6.
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  236. Goldberg AL, Rothfus WE, Deeb ZL, Daffner RH, Lupetin AR, Wilberger JE, Prostko ER. The impact of magnetic resonance on the diagnostic evaluation of acute cervicothoracic spinal trauma. Skeletal Radiol. 1988; 17(2):89-95.
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  237. Deeb ZL, Daffner RH, Rothfus WE, Goldberg AL, Tabas JH, Wilberger JE. Syringomyelia: myelography, computed tomography, and magnetic resonance imaging. J Comput Tomogr. 1988 Jan; 12(1):1-8.
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  238. Menon AS, Goldberg AL. Binding of nucleotides to the ATP-dependent protease La from Escherichia coli. J Biol Chem. 1987 Nov 5; 262(31):14921-8.
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  239. Menon AS, Goldberg AL. Protein substrates activate the ATP-dependent protease La by promoting nucleotide binding and release of bound ADP. J Biol Chem. 1987 Nov 5; 262(31):14929-34.
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  240. Rothfus WE, Goldberg AL, Tabas JH, Deeb ZL. Callosomarginal infarction secondary to transfalcial herniation. AJNR Am J Neuroradiol. 1987 Nov-Dec; 8(6):1073-6.
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  241. Goldberg AL, Menon AS, Goff S, Chin DT. The mechanism and regulation of the ATP-dependent protease La from Escherichia coli. Biochem Soc Trans. 1987 Oct; 15(5):809-11.
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  242. Hwang BJ, Park WJ, Chung CH, Goldberg AL. Escherichia coli contains a soluble ATP-dependent protease (Ti) distinct from protease La. Proc Natl Acad Sci U S A. 1987 Aug; 84(16):5550-4.
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  243. Billings PC, Carew JA, Keller-McGandy CE, Goldberg AL, Kennedy AR. A serine protease activity in C3H/10T1/2 cells that is inhibited by anticarcinogenic protease inhibitors. Proc Natl Acad Sci U S A. 1987 Jul; 84(14):4801-5.
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  244. Davies KJ, Goldberg AL. Oxygen radicals stimulate intracellular proteolysis and lipid peroxidation by independent mechanisms in erythrocytes. J Biol Chem. 1987 Jun 15; 262(17):8220-6.
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  245. Davies KJ, Goldberg AL. Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cells. J Biol Chem. 1987 Jun 15; 262(17):8227-34.
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  246. Kettelhut IC, Fiers W, Goldberg AL. The toxic effects of tumor necrosis factor in vivo and their prevention by cyclooxygenase inhibitors. Proc Natl Acad Sci U S A. 1987 Jun; 84(12):4273-7.
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  247. Fagan JM, Waxman L, Goldberg AL. Skeletal muscle and liver contain a soluble ATP + ubiquitin-dependent proteolytic system. Biochem J. 1987 Apr 15; 243(2):335-43.
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  248. Goff SA, Goldberg AL. An increased content of protease La, the lon gene product, increases protein degradation and blocks growth in Escherichia coli. J Biol Chem. 1987 Apr 5; 262(10):4508-15.
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  249. Waxman L, Fagan JM, Goldberg AL. Demonstration of two distinct high molecular weight proteases in rabbit reticulocytes, one of which degrades ubiquitin conjugates. J Biol Chem. 1987 Feb 25; 262(6):2451-7.
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  250. Menon AS, Waxman L, Goldberg AL. The energy utilized in protein breakdown by the ATP-dependent protease (La) from Escherichia coli. J Biol Chem. 1987 Jan 15; 262(2):722-6.
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  251. Fiers W, Brouckaert P, Goldberg AL, Kettelhut I, Suffys P, Tavernier J, Vanhaesebroeck B, Van Roy F. Structure-function relationship of tumour necrosis factor and its mechanism of action. Ciba Found Symp. 1987; 131:109-23.
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  252. Tanaka K, Ii K, Ichihara A, Waxman L, Goldberg AL. A high molecular weight protease in the cytosol of rat liver. I. Purification, enzymological properties, and tissue distribution. J Biol Chem. 1986 Nov 15; 261(32):15197-203.
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  253. Baracos VE, Goldberg AL. Maintenance of normal length improves protein balance and energy status in isolated rat skeletal muscles. Am J Physiol. 1986 Oct; 251(4 Pt 1):C588-96.
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  254. Furuno K, Goldberg AL. The activation of protein degradation in muscle by Ca2+ or muscle injury does not involve a lysosomal mechanism. Biochem J. 1986 Aug 1; 237(3):859-64.
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  255. Baracos V, Greenberg RE, Goldberg AL. Influence of calcium and other divalent cations on protein turnover in rat skeletal muscle. Am J Physiol. 1986 Jun; 250(6 Pt 1):E702-10.
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  256. Fagan JM, Waxman L, Goldberg AL. Red blood cells contain a pathway for the degradation of oxidant-damaged hemoglobin that does not require ATP or ubiquitin. J Biol Chem. 1986 May 5; 261(13):5705-13.
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  257. Waxman L, Goldberg AL. Selectivity of intracellular proteolysis: protein substrates activate the ATP-dependent protease (La). Science. 1986 Apr 25; 232(4749):500-3.
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  258. Ananthan J, Goldberg AL, Voellmy R. Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes. Science. 1986 Apr 25; 232(4749):522-4.
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  259. Fagan JM, Goldberg AL. Inhibitors of protein and RNA synthesis cause a rapid block in prostaglandin production at the prostaglandin synthase step. Proc Natl Acad Sci U S A. 1986 Apr; 83(8):2771-5.
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  260. Goldberg AL, Rosenbaum AE, Wang H, Kim WS, Lewis VL, Hanley DF. Computed tomography of dural sinus thrombosis. J Comput Assist Tomogr. 1986 Jan-Feb; 10(1):16-20.
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  261. Edmunds T, Goldberg AL. Role of ATP hydrolysis in the degradation of proteins by protease La from Escherichia coli. J Cell Biochem. 1986; 32(3):187-91.
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  262. Downs D, Waxman L, Goldberg AL, Roth J. Isolation and characterization of lon mutants in Salmonella typhimurium. J Bacteriol. 1986 Jan; 165(1):193-7.
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  263. Goldberg AL, Waxman L. The role of ATP hydrolysis in the breakdown of proteins and peptides by protease La from Escherichia coli. J Biol Chem. 1985 Oct 5; 260(22):12029-34.
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  264. Waxman L, Goldberg AL. Protease La, the lon gene product, cleaves specific fluorogenic peptides in an ATP-dependent reaction. J Biol Chem. 1985 Oct 5; 260(22):12022-8.
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  265. Waxman L, Fagan JM, Tanaka K, Goldberg AL. A soluble ATP-dependent system for protein degradation from murine erythroleukemia cells. Evidence for a protease which requires ATP hydrolysis but not ubiquitin. J Biol Chem. 1985 Oct 5; 260(22):11994-2000.
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  266. Goff SA, Goldberg AL. Production of abnormal proteins in E. coli stimulates transcription of lon and other heat shock genes. Cell. 1985 Jun; 41(2):587-95.
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  267. Goldberg AL. Liquid chromatographic determination of 2-(2-quinolinyl)-1H-indene-1,3-[2H]-dione and other organic-soluble matter in D&C Yellow No. 10. J Assoc Off Anal Chem. 1985 May-Jun; 68(3):477-9.
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  268. Calvey RJ, Goldberg AL. Liquid chromatographic determination of intermediates in D&C Yellow No. 7 and D&C Yellow No. 8. J Assoc Off Anal Chem. 1985 May-Jun; 68(3):471-3.
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  269. Fagan JM, Goldberg AL. The rate of protein degradation in isolated skeletal muscle does not correlate with reduction-oxidation status. Biochem J. 1985 May 1; 227(3):689-94.
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  270. Desautels M, Goldberg AL. The ATP-dependent breakdown of proteins in mammalian mitochondria. Biochem Soc Trans. 1985 Apr; 13(2):290-3.
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  271. Gronostajski RM, Pardee AB, Goldberg AL. The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts. J Biol Chem. 1985 Mar 25; 260(6):3344-9.
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  272. Goldberg AL, Voellmy R, Chung CH, Menon AS, Desautels M, Meixsell T, Waxman L. The ATP dependent pathway for protein breakdown in bacteria and mitochondria. Prog Clin Biol Res. 1985; 180:33-45.
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  273. Baracos VE, Goldberg AL. Ca2+, interleukin-1 and failure to maintain normal length stimulate protein degradation in isolated skeletal muscle. Prog Clin Biol Res. 1985; 180:603-5.
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  274. Goff SA, Casson LP, Goldberg AL. Heat shock regulatory gene htpR influences rates of protein degradation and expression of the lon gene in Escherichia coli. Proc Natl Acad Sci U S A. 1984 Nov; 81(21):6647-51.
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  275. Gronostajski RM, Goldberg AL, Pardee AB. The role of increased proteolysis in the atrophy and arrest of proliferation in serum-deprived fibroblasts. J Cell Physiol. 1984 Oct; 121(1):189-98.
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  276. Goldberg AL, Baracos V, Rodemann P, Waxman L, Dinarello C. Control of protein degradation in muscle by prostaglandins, Ca2+, and leukocytic pyrogen (interleukin 1). Fed Proc. 1984 Apr; 43(5):1301-6.
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  277. Tanaka K, Waxman L, Goldberg AL. Vanadate inhibits the ATP-dependent degradation of proteins in reticulocytes without affecting ubiquitin conjugation. J Biol Chem. 1984 Mar 10; 259(5):2803-9.
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  278. Gronostajski RM, Goldberg AL, Pardee AB. Energy requirement for degradation of tumor-associated protein p53. Mol Cell Biol. 1984 Mar; 4(3):442-8.
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  279. Baracos VE, Wilson EJ, Goldberg AL. Effects of temperature on protein turnover in isolated rat skeletal muscle. Am J Physiol. 1984 Jan; 246(1 Pt 1):C125-30.
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  280. Chung CH, Ives HE, Almeda S, Goldberg AL. Purification from Escherichia coli of a periplasmic protein that is a potent inhibitor of pancreatic proteases. J Biol Chem. 1983 Sep 25; 258(18):11032-8.
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  281. Goldberg AL, Tievsky AL, Jamshidi S. Wegener granulomatosis invading the cavernous sinus: a CT demonstration. J Comput Assist Tomogr. 1983 Aug; 7(4):701-3.
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  282. Swamy KH, Chung CH, Goldberg AL. Isolation and characterization of protease do from Escherichia coli, a large serine protease containing multiple subunits. Arch Biochem Biophys. 1983 Jul 15; 224(2):543-54.
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  283. Tanaka K, Waxman L, Goldberg AL. ATP serves two distinct roles in protein degradation in reticulocytes, one requiring and one independent of ubiquitin. J Cell Biol. 1983 Jun; 96(6):1580-5.
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  284. Chung CH, Goldberg AL. Purification and characterization of protease So, a cytoplasmic serine protease in Escherichia coli. J Bacteriol. 1983 Apr; 154(1):231-8.
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  285. Baracos V, Rodemann HP, Dinarello CA, Goldberg AL. Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever. N Engl J Med. 1983 Mar 10; 308(10):553-8.
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  286. Kirschner RJ, Goldberg AL. A high molecular weight metalloendoprotease from the cytosol of mammalian cells. J Biol Chem. 1983 Jan 25; 258(2):967-76.
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  287. Chung CH, Waxman L, Goldberg AL. Studies of the protein encoded by the lon mutation, capR9, in Escherichia coli. A labile form of the ATP-dependent protease La that inhibits the wild type protease. J Biol Chem. 1983 Jan 10; 258(1):215-21.
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  288. Desautels M, Goldberg AL. Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria. J Biol Chem. 1982 Oct 10; 257(19):11673-9.
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  289. Rodemann HP, Waxman L, Goldberg AL. The stimulation of protein degradation in muscle by Ca2+ is mediated by prostaglandin E2 and does not require the calcium-activated protease. J Biol Chem. 1982 Aug 10; 257(15):8716-23.
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  290. Waxman L, Goldberg AL. Protease La from Escherichia coli hydrolyzes ATP and proteins in a linked fashion. Proc Natl Acad Sci U S A. 1982 Aug; 79(16):4883-7.
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  291. Larimore FS, Waxman L, Goldberg AL. Studies of the ATP-dependent proteolytic enzyme, protease La, from Escherichia coli. J Biol Chem. 1982 Apr 25; 257(8):4187-95.
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  292. Swamy KH, Goldberg AL. Subcellular distribution of various proteases in Escherichia coli. J Bacteriol. 1982 Mar; 149(3):1027-33.
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  293. Desautels M, Goldberg AL. Liver mitochondria contain an ATP-dependent, vanadate-sensitive pathway for the degradation of proteins. Proc Natl Acad Sci U S A. 1982 Mar; 79(6):1869-73.
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  294. Goldberg AL, Boches FS. Oxidized proteins in erythrocytes are rapidly degraded by the adenosine triphosphate-dependent proteolytic system. Science. 1982 Feb 26; 215(4536):1107-9.
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  295. Rodemann HP, Goldberg AL. Arachidonic acid, prostaglandin E2 and F2 alpha influence rates of protein turnover in skeletal and cardiac muscle. J Biol Chem. 1982 Feb 25; 257(4):1632-8.
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  296. Tischler ME, Desautels M, Goldberg AL. Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle? J Biol Chem. 1982 Feb 25; 257(4):1613-21.
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  297. Boches FS, Goldberg AL. Role for the adenosine triphosphate-dependent proteolytic pathway in reticulocyte maturation. Science. 1982 Feb 19; 215(4535):978-80.
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  298. Chung CH, Goldberg AL. DNA stimulates ATP-dependent proteolysis and protein-dependent ATPase activity of protease La from Escherichia coli. Proc Natl Acad Sci U S A. 1982 Feb; 79(3):795-9.
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  299. Klemes Y, Etlinger JD, Goldberg AL. Properties of abnormal proteins degraded rapidly in reticulocytes. Intracellular aggregation of the globin molecules prior to hydrolysis. J Biol Chem. 1981 Aug 25; 256(16):8436-44.
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  300. Swamy KH, Goldberg AL. E. coli contains eight soluble proteolytic activities, one being ATP dependent. Nature. 1981 Aug 13; 292(5824):652-4.
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  301. Chung CH, Goldberg AL. The product of the lon (capR) gene in Escherichia coli is the ATP-dependent protease, protease La. Proc Natl Acad Sci U S A. 1981 Aug; 78(8):4931-5.
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  302. Libby P, Goldberg AL. Comparison of the control and pathways for degradation of the acetylcholine receptor and average protein in cultured muscle cells. J Cell Physiol. 1981 May; 107(2):185-94.
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  303. Voellmy RW, Goldberg AL. ATP-stimulated endoprotease is associated with the cell membrane of E. coli. Nature. 1981 Apr 2; 290(5805):419-21.
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  304. Kirschner RJ, Goldberg AL. nonlysosomal insulin-degrading proteinases in mammalian cells. Methods Enzymol. 1981; 80 Pt C:702-11.
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  305. DeMartino GN, Goldberg AL. A possible explanation of myxedema and hypercholesterolemia in hypothyroidism: control of lysosomal hyaluronidase and cholesterol esterase by thyroid hormones. Enzyme. 1981; 26(1):1-7.
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  306. Goldberg AL, Swamy KH, Chung CH, Larimore FS. Proteases in Escherichia coli. Methods Enzymol. 1981; 80 Pt C:680-702.
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  307. Goldberg AL, Tischler M, Libby P. Regulation of protein degradation in skeletal muscle. Biochem Soc Trans. 1980 Oct; 8(5):497.
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  308. Tischler ME, Goldberg AL. Leucine degradation and release of glutamine and alanine by adipose tissue. J Biol Chem. 1980 Sep 10; 255(17):8074-81.
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  309. St John AC, Goldberg AL. Effects of starvation for potassium and other inorganic ions on protein degradation and ribonucleic acid synthesis in Escherichia coli. J Bacteriol. 1980 Sep; 143(3):1223-33.
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  310. Etlinger JD, Goldberg AL. Control of protein degradation in reticulocytes and reticulocyte extracts by hemin. J Biol Chem. 1980 May 25; 255(10):4563-8.
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  311. Tischler ME, Goldberg AL. Amino acid degradation and effect of leucine on pyruvate oxidation in rat atrial muscle. Am J Physiol. 1980 May; 238(5):E480-6.
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  312. Tischler ME, Goldberg AL. Production of alanine and glutamine by atrial muscle from fed and fasted rats. Am J Physiol. 1980 May; 238(5):E487-93.
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  313. Libby P, Goldberg AL. Effects of chymostatin and other proteinase inhibitors on protein breakdown and proteolytic activities in muscle. Biochem J. 1980 Apr 15; 188(1):213-20.
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  314. Ruch FE, Lin EC, Kowit JD, Tang CT, Goldberg AL. In vivo inactivation of glycerol dehydrogenase in Klebsiella aerogenes: properties of active and inactivated proteins. J Bacteriol. 1980 Mar; 141(3):1077-85.
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  315. Voellmy R, Goldberg AL. Guanosine-5'-diphosphate-3'-diphosphate (ppGpp) and the regulation of protein breakdown in Escherichia coli. J Biol Chem. 1980 Feb 10; 255(3):1008-14.
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  316. Libby P, Bursztajn S, Goldberg AL. Degradation of the acetylcholine receptor in cultured muscle cells: selective inhibitors and the fate of undegraded receptors. Cell. 1980 Feb; 19(2):481-91.
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  317. Goldberg AL, Tischler M, DeMartino G, Griffin G. Hormonal regulation of protein degradation and synthesis in skeletal muscle. Fed Proc. 1980 Jan; 39(1):31-6.
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  318. Neff NT, DeMartino GN, Goldberg AL. The effect of protease inhibitors and decreased temperature on the degradation of different classes of proteins in cultured hepatocytes. J Cell Physiol. 1979 Dec; 101(3):439-57.
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  319. Murakami K, Voellmy R, Goldberg AL. Protein degradation is stimulated by ATP in extracts of Escherichia coli. J Biol Chem. 1979 Sep 10; 254(17):8194-200.
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  320. Libby P, Ingwall JS, Goldberg AL. Reduction of protein degradation and atrophy in cultured fetal mouse hearts by leupeptin. Am J Physiol. 1979 Jul; 237(1):E35-9.
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  321. DeMartino GN, Goldberg AL. Identification and partial purification of an ATP-stimulated alkaline protease in rat liver. J Biol Chem. 1979 May 25; 254(10):3712-5.
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  322. Dice JF, Hess EJ, Goldberg AL. Studies on the relationship between the degradative rates of proteins in vivo and their isoelectric points. Biochem J. 1979 Feb 15; 178(2):305-12.
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  323. Odessey R, Goldberg AL. Leucine degradation in cell-free extracts of skeletal muscle. Biochem J. 1979 Feb 15; 178(2):475-89.
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  324. Goldberg AL. Influence of insulin and contractile activity on muscle size and protein balance. Diabetes. 1979 Jan; 28 Suppl 1:18-24.
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  325. Goldberg AL, Strnad NP, Swamy KH. Studies of the ATP dependence of protein degradation in cells and cell extracts. Ciba Found Symp. 1979; (75):227-51.
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  326. Goldberg AL, Chang TW. Regulation and significance of amino acid metabolism in skeletal muscle. Fed Proc. 1978 Jul; 37(9):2301-7.
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  327. St John AC, Conklin K, Rosenthal E, Goldberg AL. Further evidence for the involvement of charged tRNA and guanosine tetraphosphate in the control of protein degradation in Escherichia coli. J Biol Chem. 1978 Jun 10; 253(11):3945-51.
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  328. Chang TW, Goldberg AL. A relationship between the rates of acetyl group oxidation and the oxygen consumption of cellls. J Biol Chem. 1978 May 25; 253(10):3693-5.
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  329. Chang TW, Goldberg AL. Leucine inhibits oxidation of glucose and pyruvate in skeletal muscles during fasting. J Biol Chem. 1978 May 25; 253(10):3696-701.
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  330. Chang TW, Goldberg AL. The origin of alanine produced in skeletal muscle. J Biol Chem. 1978 May 25; 253(10):3677-84.
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  331. Chang TW, Goldberg AL. The metabolic fates of amino acids and the formation of glutamine in skeletal muscle. J Biol Chem. 1978 May 25; 253(10):3685-93.
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  332. St John AC, Goldberg AL. Effects of reduced energy production on protein degradation, guanosine tetraphosphate, and RNA synthesis in Escherichia coli. J Biol Chem. 1978 Apr 25; 253(8):2705-11.
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  333. DeMartino GN, Goldberg AL. Thyroid hormones control lysosomal enzyme activities in liver and skeletal muscle. Proc Natl Acad Sci U S A. 1978 Mar; 75(3):1369-73.
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  334. Libby P, Goldberg AL. Leupeptin, a protease inhibitor, decreases protein degradation in normal and diseased muscles. Science. 1978 Feb 3; 199(4328):534-6.
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  335. Kowit JD, Goldberg AL. Intermediate steps in the degradation of a specific abnormal protein in Escherichia coli. J Biol Chem. 1977 Dec 10; 252(23):8350-7.
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  336. Goldberg AL, Griffin GE. Hormonal control of protein synthesis and degradation in rat skeletal muscle [proceedings]. J Physiol. 1977 Aug; 270(1):51P-52P.
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  337. Etlinger JD, Goldberg AL. A soluble ATP-dependent proteolytic system responsible for the degradation of abnormal proteins in reticulocytes. Proc Natl Acad Sci U S A. 1977 Jan; 74(1):54-8.
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  338. Kowit JD, Choy WN, Champe SP, Goldberg AL. Role and location of "protease I" from Escherichia coli. J Bacteriol. 1976 Dec; 128(3):776-84.
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  339. Dive JF, Goldberg AL. Structural properties of rat serum proteins which correlate with their degradative rates in vivo. Nature. 1976 Aug 5; 262(5568):514-6.
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  340. Li JB, Goldberg AL. Effects of food deprivation on protein synthesis and degradation in rat skeletal muscles. Am J Physiol. 1976 Aug; 231(2):441-8.
    View in: PubMed
  341. Chaplin ER, Goldberg AL, Diamond I. Leucine oxidation in brain slices and nerve endings. J Neurochem. 1976 Apr; 26(4):701-7.
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  342. Goldberg AL, St John AC. Intracellular protein degradation in mammalian and bacterial cells: Part 2. Annu Rev Biochem. 1976; 45:747-803.
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  343. Dice JF, Goldberg AL. Relationship between in vivo degradative rates and isoelectric points of proteins. Proc Natl Acad Sci U S A. 1975 Oct; 72(10):3893-7.
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  344. Dice JF, Goldberg AL. A statistical analysis of the relationship between degradative rates and molecular weights of proteins. Arch Biochem Biophys. 1975 Sep; 170(1):213-9.
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  345. Prouty WF, Karnovsky MJ, Goldberg AL. Degradation of abnormal proteins in Escherichia coli. Formation of protein inclusions in cells exposed to amino acid analogs. J Biol Chem. 1975 Feb 10; 250(3):1112-22.
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  346. Fulks RM, Li JB, Goldberg AL. Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. J Biol Chem. 1975 Jan 10; 250(1):290-8.
    View in: PubMed
  347. Goldberg AL, Goldspink DF. Influence of food deprivation and adrenal steroids on DNA synthesis in various mammalian tissues. Am J Physiol. 1975 Jan; 228(1):310-7.
    View in: PubMed
  348. Goldberg AL, Etlinger JD, Goldspink DF, Jablecki C. Mechanism of work-induced hypertrophy of skeletal muscle. Med Sci Sports. 1975; 7(3):185-98.
    View in: PubMed
  349. Goldspink DF, Goldberg AL. Influence of pituitary growth hormone on DNA synthesis in rat tissues. Am J Physiol. 1975 Jan; 228(1):302-9.
    View in: PubMed
  350. Goldberg AL, Martel SB, Kushmerick MJ. In vitro preparations of the diaphragm and other skeletal muscles. Methods Enzymol. 1975; 39:82-94.
    View in: PubMed
  351. Odessey R, Khairallah EA, Goldberg AL. Origin and possible significance of alanine production by skeletal muscle. J Biol Chem. 1974 Dec 10; 249(23):7623-9.
    View in: PubMed
  352. Goldberg AL, Howell EM, Li JB, Martel SB, Prouty WF. Physiological significance of protein degradation in animal and bacterial cells. Fed Proc. 1974 Apr; 33(4):1112-20.
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  353. Goldberg AL, Jablecki C, Li JB. Trophic functions of the neuron. 3. Mechanisms of neurotrophic interactions. Effects of use and disuse on amino acid transport and protein turnover in muscle. Ann N Y Acad Sci. 1974 Mar 22; 228(0):190-201.
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  354. Goldberg AL, Dice JF. Intracellular protein degradation in mammalian and bacterial cells. Annu Rev Biochem. 1974; 43(0):835-69.
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  355. Li JB, Fulks RM, Goldberg AL. Evidence that the intracellular pool of tyrosine serves as precursor for protein synthesis in muscle. J Biol Chem. 1973 Oct 25; 248(20):7272-5.
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  356. Goldspink DF, Goldberg AL. The apparent stimulation of proteolysis by adenosine triphosphate in tissue homogenates. Biochem J. 1973 Jul; 134(3):829-32.
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  357. Goldspink DF, Goldberg AL. Problems in the use of (Me- 3H) thymidine for the measurement of DNA synthesis. Biochim Biophys Acta. 1973 Apr 11; 299(4):521-32.
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  358. Low RB, Goldberg AL. Nonuniform rates of turnover of myofibrillar proteins in rat diaphragm. J Cell Biol. 1973 Feb; 56(2):590-5.
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  359. Goldberg AL, Odessey R. Oxidation of amino acids by diaphragms from fed and fasted rats. Am J Physiol. 1972 Dec; 223(6):1384-91.
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  360. Odessey R, Goldberg AL. Oxidation of leucine by rat skeletal muscle. Am J Physiol. 1972 Dec; 223(6):1376-83.
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  361. Prouty WF, Goldberg AL. Fate of abnormal proteins in E. coli accumulation in intracellular granules before catabolism. Nat New Biol. 1972 Nov 29; 240(100):147-50.
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  362. Goldberg AL. Correlation between rates of degradation of bacterial proteins in vivo and their sensitivity to proteases. Proc Natl Acad Sci U S A. 1972 Sep; 69(9):2640-4.
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  363. Prouty WF, Goldberg AL. Effects of protease inhibitors on protein breakdown in Escherichia coli. J Biol Chem. 1972 May 25; 247(10):3341-52.
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  364. Goldberg AL. Degradation of abnormal proteins in Escherichia coli (protein breakdown-protein structure-mistranslation-amino acid analogs-puromycin). Proc Natl Acad Sci U S A. 1972 Feb; 69(2):422-6.
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  365. Goldberg AL. Mechanisms of growth and atrophy of skeletal muscle. Muscle Biol. 1972; 1:89-118.
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  366. Goldberg AL. Effects of protease inhibitors on protein breakdown and enzyme induction in starving Escherichia coli. Nat New Biol. 1971 Nov 10; 234(45):51-2.
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  367. Diamond I, Goldberg AL. Uptake and release of 45Ca by brain microsomes, synaptosomes and synaptic vesicles. J Neurochem. 1971 Aug; 18(8):1419-31.
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  368. Goldberg AL. A role of aminoacyl-tRNA in the regulation of protein breakdown in Escherichia coli. Proc Natl Acad Sci U S A. 1971 Feb; 68(2):362-6.
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  369. Singer JJ, Goldberg AL. Cyclic AMP and transmission at the neuromuscular junction. Adv Biochem Psychopharmacol. 1970; 3:335-48.
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  370. Goldberg AL, Singer JJ. Evidence for a role of cyclic AMP in neuromuscular transmission. Proc Natl Acad Sci U S A. 1969 Sep; 64(1):134-41.
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  371. Goldberg AL. Protein turnover in skeletal muscle. II. Effects of denervation and cortisone on protein catabolism in skeletal muscle. J Biol Chem. 1969 Jun 25; 244(12):3223-9.
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  372. Goldberg AL. Protein turnover in skeletal muscle. I. Protein catabolism during work-induced hypertrophy and growth induced with growth hormone. J Biol Chem. 1969 Jun 25; 244(12):3217-22.
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  373. Goldberg AL, Goodman HM. Effects od disuse and denervation on amino acid transport by skeletal muscle. Am J Physiol. 1969 May; 216(5):1116-9.
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  374. Goldberg AL, Goodman HM. Amino acid transport during work-induced growth of skeletal muscle. Am J Physiol. 1969 May; 216(5):1111-5.
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  375. Goldberg AL, Goodman HM. Relationship between cortisone and muscle work in determining muscle size. J Physiol. 1969 Feb; 200(3):667-75.
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  376. Goldberg AL, Goodman HM. Relationship between growth hormone and muscular work in determining muscle size. J Physiol. 1969 Feb; 200(3):655-66.
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  377. Goldberg AL. Role of insulin in work-induced growth of skeletal muscle. Endocrinology. 1968 Nov; 83(5):1071-3.
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  378. Goldberg AL. Protein synthesis during work-induced growth of skeletal muscle. J Cell Biol. 1968 Mar; 36(3):653-8.
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  379. Goldberg AL. Protein synthesis in tonic and phasic skeletal muscles. Nature. 1967 Dec 23; 216(5121):1219-20.
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  380. Goldberg AL. Work-induced growth of skeletal muscle in normal and hypophysectomized rats. Am J Physiol. 1967 Nov; 213(5):1193-8.
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  381. Goldberg AL, Wittes RE. Genetic code: aspects of organization. Science. 1966 Jul 22; 153(3734):420-4.
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