Alfred Lewis Goldberg, Ph.D.
|Title||Professor of Cell Biology|
|Institution||Harvard Medical School|
|Address||Harvard Medical School|
Bldg. C-1, Rm. 415
240 Longwood Ave
Boston MA 02115
Available: 10/20/11, Expires: 06/30/15
The goal of these studies is to learn more about the cellular adaptations that lead to wasting of skeletal, as occurs upon disuse, denervation, fasting, cancer (cachexia) and aging. Several research projects are available, and the scope and precise question to be investigated will depend upon the student's interests and prior laboratory experience in biochemistry and cell or molecular biology. One major goal is to learn about the changes in gene transcription that are common to various types of atrophy and how this program is suppressed in hypertrophying muscle. A second opportunity would concern the biochemical mechanisms that catalyze the disassembly and degradation of components of the sarcomeric apparatus during atrophy (and its buildup during hypertrophy) in skeletal and cardiac muscle. The student(s) would do laboratory research in the Dept of Cell Biology under the supervision of Dr. Goldberg and a senior postdoctoral fellow (who has had prior teaching experience).
Protein Degradation by Proteasomes from T. Acidophilum: Effects of mutations in the Opening to the Alpha-ring
Summer, 05/15/99 - 08/10/99
Role of the Chemical Chaperone Trehalose in the Near-freezing Stress Response of S. cerevisiae
Summer, 06/01/06 - 09/01/06
Implications of SODI Mutations in Familiar Amyotrophic Lateral Sclerosis
Part Time, 01/03/00 - 06/16/00
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