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Last Name
Institution

Raymond Taeyong Chung, M.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
WRN 1007C, GI Unit
55 Fruit St
Boston MA 02114
Phone617/724-7562
Fax617/643-0446

 Mentoring 
 current student opportunities
Available: 06/01/13, Expires: 09/30/14

Biomarkers that accurately assess risk for HCC are sorely lacking. Based on work originally conducted here at MGH, we found that a polymorphism in the EGF gene that predicts overexpression was associated with a significantly higher risk for HCC (adjusted OR of 3.49) in a case-control study of 328 patients from two countries with cirrhosis of varying etiology (Tanabe K et al, JAMA 2008). More recently, we conducted a study using the prospective NIH HALT-C cohort to verify these findings. We not only confirmed this elevated risk in persons harboring the EGF risk allele (OR=2.10), but found that this polymorphism accounted for the excess risk of HCC among blacks. Moreover, we incorporated EGF genotype with other, common clinical variables into a clinical prediction model that divided the HALT-C group into low (2.3%), intermediate (10.4%), and high (26%)cumulative 6-year risk groups for development of HCC (Abu Dayyeh B et al, Gastroenterology 2011). These data firmly offer a fruitful application of genetic information into robust risk models for HCC. With the help of a medical student, we now plan to extend this work to incorporate gene arrays on liver biopsies corresponding to a gene expression "signature" previously demonstrated to be associated with a high risk for HCC and liver failure in persons with HCV (Hoshida Y et al, NEJM). This study offers firm training and exposure in the translational research continuum and the opportunity to identify persons at particularly high risk for HCC, so that early screening and prevention may be applied.

Available: 07/01/13, Expires: 06/30/14

The MGH Gastroenterology Division and NIDDK are offering one-year NIH-funded Pre-doctoral Research Fellowships at MGH for medical students. This is an ideal opportunity for year 3 medical students interested in exploring fundamental, translational, or clinical research in gastrointestinal and liver diseases as a possible career. Those accepted will engage in a hands-on research project under the mentorship of a leading investigator within the GI Division at MGH. These investigators include Drs. Andrew Chan, Michael Choi, Raymond Chung, Daniel Chung, Chin Hur, Lee Kaplan, Georg Lauer, Rodrigo Mora, Christian Reinecker, Scott Snapper, and Ramnik Xavier. A stipend is provided. Funds to support attendance at national meetings are also provided. Applications will be accepted on a rolling basis with the planned Fellowship year to begin July 2012, based on arrangements with the mentor. Eligible candidates must be in good academic standing and have completed at least their second year at an accredited U.S. medical school by July 1, 2011. Students from underrepresented minority groups are strongly encouraged to apply. Additional information is available by contacting Dr. Raymond Chung at rtchung@partners.org (telephone 617-724-7562).

 completed student projects
Pilot Protocol of Antiviral Prophylaxis Against HIV Recurrence in Orthotopic Liver Transplantation Recipients PASTEUR
Part Time/Continuation, 01/01/02 - 03/01/02
The Liver Health Project - Addressing Hepatitis B Infections in Boston
Community Service, 05/01/10 - 05/07/11
Investigation of the Effect of Hepatitis C Virus Infection on Serum Cholesterol Levels
Summer, 06/18/07 - 08/10/07
Effects of n-acetylcysteine on clinical outcomes in acute liver failure
Summer, 06/16/08 - 08/11/08
Analysis of the Quasispecies Diversity of Hepatitis C Infection in HIV Co-infected Patients Undergoing Highly Active Antiretroviral Therapy PASTEUR
Summer, 06/26/00 - 08/18/00
Pilot Protocol of Antiviral Prophylaxis Against HIV Recurrence in Orthotopic Liver Transplantation Recipients PASTEUR
Part Time/Continuation, 09/17/01 - 12/21/01
A Preliminary Trial of Oral Ribavirin to Reduce the Frequency of Liver Allograft Rejection in Subjects Undergoing Transplant for Hepatitis C-related Cirrhosis PASTEUR
Summer, 06/25/01 - 08/17/01

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nakahira K, Kyung SY, Rogers AJ, Gazourian L, Youn S, Massaro AF, Quintana C, Osorio JC, Wang Z, Zhao Y, Lawler LA, Christie JD, Meyer NJ, Causland FR, Waikar SS, Waxman AB, Chung RT, Bueno R, Rosas IO, Fredenburgh LE, Baron RM, Christiani DC, Hunninghake GM, Choi AM. Circulating mitochondrial DNA in patients in the ICU as a marker of mortality: derivation and validation. PLoS Med. 2013 Dec; 10(12):e1001577.
    View in: PubMed
  2. Scaiewicz V, Nahmias A, Chung RT, Mueller T, Tirosh B, Shibolet O. CCAAT/Enhancer-Binding Protein Homologous (CHOP) Protein Promotes Carcinogenesis in the DEN-Induced Hepatocellular Carcinoma Model. PLoS One. 2013; 8(12):e81065.
    View in: PubMed
  3. Zator ZA, Chung RT. After the Cure: Management of HCV After Achievement of SVR. Curr HIV/AIDS Rep. 2013 Dec; 10(4):428-35.
    View in: PubMed
  4. Sherman KE, Thomas D, Chung RT. Human immunodeficiency virus and liver disease forum 2012. Hepatology. 2014 Jan; 59(1):307-17.
    View in: PubMed
  5. Rottiers V, Obad S, Petri A, McGarrah R, Lindholm MW, Black JC, Sinha S, Goody RJ, Lawrence MS, Delemos AS, Hansen HF, Whittaker S, Henry S, Brookes R, Najafi-Shoushtari SH, Chung RT, Whetstine JR, Gerszten RE, Kauppinen S, Näär AM. Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR. Sci Transl Med. 2013 Nov 20; 5(212):212ra162.
    View in: PubMed
  6. Schaefer EA, Chung RT. HCV and host lipids: an intimate connection. Semin Liver Dis. 2013 Nov; 33(4):358-68.
    View in: PubMed
  7. Amorosa VK, Luetkemeyer A, Kang M, Johnson VA, Umbleja T, Haas DW, Yesmin S, Bardin MC, Chung RT, Alston-Smith B, Tebas P, Peters MG. Addition of Nitazoxanide to PEG-IFN and Ribavirin to Improve HCV Treatment Response in HIV-1 and HCV Genotype 1 Coinfected Persons Naïve to HCV Therapy: Results of the ACTG A5269 Trial. HIV Clin Trials. 2013 Nov-Dec; 14(6):274-83.
    View in: PubMed
  8. Kroy DC, Ciuffreda D, Cooperrider JH, Tomlinson M, Hauck GD, Aneja J, Berger C, Wolski D, Carrington M, Wherry EJ, Chung RT, Tanabe KK, Elias N, Freeman GJ, de Kruyff RH, Misdraji J, Kim AY, Lauer GM. Liver environment and HCV replication affect human T-cell phenotype and expression of inhibitory receptors. Gastroenterology. 2014 Feb; 146(2):550-61.
    View in: PubMed
  9. Bailey CM, Sullivan TJ, Iyidogan P, Tirado-Rives J, Chung R, Ruiz-Caro J, Mohamed E, Jorgensen WL, Hunter R, Anderson KS. Correction to Bifunctional Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Mechanism and Proof-of-Concept as a Novel Therapeutic Design Strategy. J Med Chem. 2013 Nov 14; 56(21):8953.
    View in: PubMed
  10. Johnson KB, Campbell EJ, Chi H, Zheng H, King LY, Wu Y, Delemos A, Hurairah A, Corey K, Richter JM, Chung RT. Advanced disease, diuretic use, and marital status predict hospital admissions in an ambulatory cirrhosis cohort. Dig Dis Sci. 2014 Jan; 59(1):174-82.
    View in: PubMed
  11. Goto K, Lin W, Zhang L, Jilg N, Shao RX, Schaefer EA, Zhao H, Fusco DN, Peng LF, Kato N, Chung RT. The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-ß signaling. J Hepatol. 2013 Nov; 59(5):942-8.
    View in: PubMed
  12. Watanabe T, Hiasa Y, Tokumoto Y, Hirooka M, Abe M, Ikeda Y, Matsuura B, Chung RT, Onji M. Protein Kinase R Modulates c-Fos and c-Jun Signaling to Promote Proliferation of Hepatocellular Carcinoma with Hepatitis C Virus Infection. PLoS One. 2013; 8(7):e67750.
    View in: PubMed
  13. John S, Andersson KL, Kotton CN, Hertl M, Markmann JF, Cosimi AB, Chung RT. Prophylaxis of hepatitis B infection in solid organ transplant recipients. Therap Adv Gastroenterol. 2013 Jul; 6(4):309-19.
    View in: PubMed
  14. Bai H, Chen T, Ming J, Sun H, Cao P, Fusco DN, Chung RT, Chorev M, Jin Q, Aktas BH. Dual Activators of Protein Kinase R (PKR) and Protein Kinase R-Like Kinase (PERK) Identify Common and Divergent Catalytic Targets. Chembiochem. 2013 Jul 8; 14(10):1255-62.
    View in: PubMed
  15. Branch AD, Kang M, Hollabaugh K, Wyatt CM, Chung RT, Glesby MJ. In HIV/hepatitis C virus co-infected patients, higher 25-hydroxyvitamin D concentrations were not related to hepatitis C virus treatment responses but were associated with ritonavir use. Am J Clin Nutr. 2013 Aug; 98(2):423-9.
    View in: PubMed
  16. Uzi D, Barda L, Scaiewicz V, Mills M, Mueller T, Gonzalez-Rodriguez A, Valverde AM, Iwawaki T, Nahmias Y, Xavier R, Chung RT, Tirosh B, Shibolet O. CHOP is a critical regulator of acetaminophen-induced hepatotoxicity. J Hepatol. 2013 Sep; 59(3):495-503.
    View in: PubMed
  17. Bailey CM, Sullivan TJ, Iyidogan P, Tirado-Rives J, Chung R, Ruiz-Caro J, Mohamed E, Jorgensen W, Hunter R, Anderson KS. Bifunctional Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Mechanism and Proof-of-Concept as a Novel Therapeutic Design Strategy. J Med Chem. 2013 May 23; 56(10):3959-68.
    View in: PubMed
  18. Corey KE, Misdraji J, Zheng H, Malecki KM, Kneeman J, Gelrud L, Chung RT. The Absence of Obstructive Sleep Apnea May Protect against Non-Alcoholic Fatty Liver in Patients Undergoing Bariatric Surgery. PLoS One. 2013; 8(5):e62504.
    View in: PubMed
  19. Lin W, Weinberg EM, Chung RT. Pathogenesis of Accelerated Fibrosis in HIV/HCV Co-infection. J Infect Dis. 2013 Mar; 207 Suppl 1:S13-8.
    View in: PubMed
  20. Jilg N, Chung RT. One more piece in the interleukin 28B gene puzzle? The case of hepatitis B. Hepatology. 2013 Mar; 57(3):870-2.
    View in: PubMed
  21. Fusco DN, Brisac C, John SP, Huang YW, Chin CR, Xie T, Zhao H, Jilg N, Zhang L, Chevaliez S, Wambua D, Lin W, Peng L, Chung RT, Brass AL. A Genetic Screen Identifies Interferon-a Effector Genes Required to Suppress Hepatitis C Virus Replication. Gastroenterology. 2013 Jun; 144(7):1438-1449.e9.
    View in: PubMed
  22. Duggal P, Thio CL, Wojcik GL, Goedert JJ, Mangia A, Latanich R, Kim AY, Lauer GM, Chung RT, Peters MG, Kirk GD, Mehta SH, Cox AL, Khakoo SI, Alric L, Cramp ME, Donfield SM, Edlin BR, Tobler LH, Busch MP, Alexander G, Rosen HR, Gao X, Abdel-Hamid M, Apps R, Carrington M, Thomas DL. Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. Ann Intern Med. 2013 Feb 19; 158(4):235-45.
    View in: PubMed
  23. King LY, Chung RT. IL28B testing in a rapidly changing world: Still relevant? J Hepatol. 2013 May; 58(5):847-9.
    View in: PubMed
  24. Hoshida Y, Villanueva A, Sangiovanni A, Sole M, Hur C, Andersson KL, Chung RT, Gould J, Kojima K, Gupta S, Taylor B, Crenshaw A, Gabriel S, Minguez B, Iavarone M, Friedman SL, Colombo M, Llovet JM, Golub TR. Prognostic gene expression signature for patients with hepatitis C-related early-stage cirrhosis. Gastroenterology. 2013 May; 144(5):1024-30.
    View in: PubMed
  25. Jeong SW, Jang JY, Chung RT. Hepatitis C virus and hepatocarcinogenesis. Clin Mol Hepatol. 2012 Dec; 18(4):347-56.
    View in: PubMed
  26. Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, Schinzel RT, Xia F, Tang A, Xia Y, Figueroa E, Wann A, Ahfeldt T, Daheron L, Zhang F, Rubin LL, Peng LF, Chung RT, Musunuru K, Cowan CA. A TALEN Genome-Editing System for Generating Human Stem Cell-Based Disease Models. Cell Stem Cell. 2013 Feb 7; 12(2):238-51.
    View in: PubMed
  27. Shao RX, Zhang L, Hong Z, Goto K, Cheng D, Chen WC, Jilg N, Kumthip K, Fusco DN, Peng LF, Chung RT. SOCS1 abrogates IFN's antiviral effect on hepatitis C virus replication. Antiviral Res. 2013 Feb; 97(2):101-7.
    View in: PubMed
  28. Chen JY, Chung RT. Future classes of hepatitis C virus therapeutic agents. Infect Dis Clin North Am. 2012 Dec; 26(4):949-66.
    View in: PubMed
  29. Rutherford A, King LY, Lee WM, Chung RT. Reply. Gastroenterology. 2013 Jan; 144(1):e26.
    View in: PubMed
  30. Asmal M, Seaman M, Lin W, Chung RT, Letvin NL, Geiben-Lynn R. Inhibition of HCV by the serpin antithrombin III. Virol J. 2012; 9:226.
    View in: PubMed
  31. Huang YW, Chung RT. Management of hepatitis B reactivation in patients receiving cancer chemotherapy. Therap Adv Gastroenterol. 2012 Sep; 5(5):359-70.
    View in: PubMed
  32. Sahani DV, Agarwal S, Chung RT. The double-edged sword of functional liver imaging. Radiology. 2012 Sep; 264(3):621-3.
    View in: PubMed
  33. Rutherford A, King LY, Hynan LS, Vedvyas C, Lin W, Lee WM, Chung RT. Development of an accurate index for predicting outcomes of patients with acute liver failure. Gastroenterology. 2012 Nov; 143(5):1237-43.
    View in: PubMed
  34. Chung RT, Stravitz RT, Fontana RJ, Schiodt FV, Mehal WZ, Reddy KR, Lee WM. Pathogenesis of liver injury in acute liver failure. Gastroenterology. 2012 Sep; 143(3):e1-7.
    View in: PubMed
  35. Delgado-Borrego A, Smith L, Jonas MM, Hall CA, Negre B, Jordan SH, Ogrodowicz M, Raza R, Ludwig DA, Miller T, Lipshultz SE, Gonzalez-Peralta R, Chung RT. Expected and actual case ascertainment and treatment rates for children infected with hepatitis C in Florida and the United States: epidemiologic evidence from statewide and nationwide surveys. J Pediatr. 2012 Nov; 161(5):915-21.
    View in: PubMed
  36. Kumthip K, Chusri P, Jilg N, Zhao L, Fusco DN, Zhao H, Goto K, Cheng D, Schaefer EA, Zhang L, Pantip C, Thongsawat S, O'Brien A, Peng LF, Maneekarn N, Chung RT, Lin W. Hepatitis C virus NS5A disrupts STAT1 phosphorylation and suppresses type I interferon signaling. J Virol. 2012 Aug; 86(16):8581-91.
    View in: PubMed
  37. Butt AA, Umbleja T, Andersen JW, Sherman KE, Chung RT. Impact of peginterferon alpha and ribavirin treatment on lipid profiles and insulin resistance in Hepatitis C virus/HIV-coinfected persons: the AIDS Clinical Trials Group A5178 Study. Clin Infect Dis. 2012 Sep; 55(5):631-8.
    View in: PubMed
  38. Schaefer EA, Chung RT. Anti-hepatitis C virus drugs in development. Gastroenterology. 2012 May; 142(6):1340-1350.e1.
    View in: PubMed
  39. Rodgers MA, Villareal VA, Schaefer EA, Peng LF, Corey KE, Chung RT, Yang PL. Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus. J Am Chem Soc. 2012 Apr 25; 134(16):6896-9.
    View in: PubMed
  40. Chung RT, Umbleja T, Chen JY, Andersen JW, Butt AA, Sherman KE. Extended therapy with pegylated interferon and weight-based ribavirin for HCV-HIV coinfected patients. HIV Clin Trials. 2012 Mar-Apr; 13(2):70-82.
    View in: PubMed
  41. Corey KE, Zheng H, Mendez-Navarro J, Delgado-Borrego A, Dienstag JL, Chung RT. Serum vitamin D levels are not predictive of the progression of chronic liver disease in hepatitis C patients with advanced fibrosis. PLoS One. 2012; 7(2):e27144.
    View in: PubMed
  42. Zhang L, Hong Z, Lin W, Shao RX, Goto K, Hsu VW, Chung RT. ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication. PLoS One. 2012; 7(2):e32135.
    View in: PubMed
  43. Corey KE, Lai M, Gelrud LG, Misdraji J, Barlow LL, Zheng H, Andersson KL, Thiim M, Pratt DS, Chung RT. Non-high-density lipoprotein cholesterol as a biomarker for nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2012 Jun; 10(6):651-6.
    View in: PubMed
  44. John S, Chung RT. Early liver transplantation for severe alcoholic hepatitis. N Engl J Med. 2012 Feb 2; 366(5):478; author reply 479.
    View in: PubMed
  45. Chung RT. A watershed moment in the treatment of hepatitis C. N Engl J Med. 2012 Jan 19; 366(3):273-5.
    View in: PubMed
  46. Schulze Zur Wiesch J, Ciuffreda D, Lewis-Ximenez L, Kasprowicz V, Nolan BE, Streeck H, Aneja J, Reyor LL, Allen TM, Lohse AW, McGovern B, Chung RT, Kwok WW, Kim AY, Lauer GM. Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence. J Exp Med. 2012 Jan 16; 209(1):61-75.
    View in: PubMed
  47. Opravil M, Rodriguez-Torres M, Rockstroh J, Snoeck E, Chung RT, Tietz A, Torriani FJ. The dose-response relationship of peginterferon alfa-2a and ribavirin in the treatment of patients coinfected with HIV-HCV. HIV Clin Trials. 2012 Jan-Feb; 13(1):33-45.
    View in: PubMed
  48. Schaefer EA, Chung RT. The impact of human gene polymorphisms on HCV infection and disease outcome. Semin Liver Dis. 2011 Nov; 31(4):375-86.
    View in: PubMed
  49. Sherman KE, Thomas DL, Chung RT. Human immunodeficiency virus and liver disease forum 2010: conference proceedings. Hepatology. 2011 Dec; 54(6):2245-53.
    View in: PubMed
  50. Dayyeh BK, Gupta N, Sherman KE, de Bakker PI, Chung RT. IL28B alleles exert an additive dose effect when applied to HCV-HIV coinfected persons undergoing peginterferon and ribavirin therapy. PLoS One. 2011; 6(10):e25753.
    View in: PubMed
  51. Taylor RM, Tujios S, Jinjuvadia K, Davern T, Shaikh OS, Han S, Chung RT, Lee WM, Fontana RJ. Short and long-term outcomes in patients with acute liver failure due to ischemic hepatitis. Dig Dis Sci. 2012 Mar; 57(3):777-85.
    View in: PubMed
  52. Fusco DN, Chung RT. Novel therapies for hepatitis C: insights from the structure of the virus. Annu Rev Med. 2012; 63:373-87.
    View in: PubMed
  53. Zhao H, Lin W, Kumthip K, Cheng D, Fusco DN, Hofmann O, Jilg N, Tai AW, Goto K, Zhang L, Hide W, Jang JY, Peng LF, Chung RT. A functional genomic screen reveals novel host genes that mediate interferon-alpha's effects against hepatitis C virus. J Hepatol. 2012 Feb; 56(2):326-33.
    View in: PubMed
  54. Peng LF, Schaefer EA, Maloof N, Skaff A, Berical A, Belon CA, Heck JA, Lin W, Frick DN, Allen TM, Miziorko HM, Schreiber SL, Chung RT. Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase. J Infect Dis. 2011 Aug 15; 204(4):609-16.
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  55. Patwardhan V, Paul S, Corey KE, Mazhar SM, Richter JM, Thiim M, Chung RT. Hepatocellular carcinoma screening rates vary by etiology of cirrhosis and involvement of gastrointestinal sub-specialists. Dig Dis Sci. 2011 Nov; 56(11):3316-22.
    View in: PubMed
  56. Jilg N, Chung RT. Adding to the toolbox: receptor tyrosine kinases as potential targets in the treatment of hepatitis C. J Hepatol. 2012 Jan; 56(1):282-4.
    View in: PubMed
  57. O'Brien TR, Everhart JE, Morgan TR, Lok AS, Chung RT, Shao Y, Shiffman ML, Dotrang M, Sninsky JJ, Bonkovsky HL, Pfeiffer RM. An IL28B genotype-based clinical prediction model for treatment of chronic hepatitis C. PLoS One. 2011; 6(7):e20904.
    View in: PubMed
  58. Jang JY, Chung RT. Chronic hepatitis C. Gut Liver. 2011 Jun; 5(2):117-32.
    View in: PubMed
  59. Abu Dayyeh BK, Yang M, Fuchs BC, Karl DL, Yamada S, Sninsky JJ, O'Brien TR, Dienstag JL, Tanabe KK, Chung RT. A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma. Gastroenterology. 2011 Jul; 141(1):141-9.
    View in: PubMed
  60. Rogal SS, Landsittel D, Surman O, Chung RT, Rutherford A. Pretransplant depression, antidepressant use, and outcomes of orthotopic liver transplantation. Liver Transpl. 2011 Mar; 17(3):251-60.
    View in: PubMed
  61. Goldwasser J, Cohen PY, Lin W, Kitsberg D, Balaguer P, Polyak SJ, Chung RT, Yarmush ML, Nahmias Y. Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism. J Hepatol. 2011 Nov; 55(5):963-71.
    View in: PubMed
  62. Chen JY, Chung RT. Can we use the "C" word with confidence? Cure for chronic hepatitis C. Gastroenterology. 2011 Mar; 140(3):766-8.
    View in: PubMed
  63. Fusco DN, Chung RT. New protease inhibitors for HCV--help is on the way. J Hepatol. 2011 Jun; 54(6):1087-9.
    View in: PubMed
  64. Sherman KE, Andersen JW, Butt AA, Umbleja T, Alston B, Koziel MJ, Peters MG, Sulkowski M, Goodman ZD, Chung RT. Sustained long-term antiviral maintenance therapy in HCV/HIV-coinfected patients (SLAM-C). J Acquir Immune Defic Syndr. 2010 Dec 15; 55(5):597-605.
    View in: PubMed
  65. Zhang L, Jilg N, Shao RX, Lin W, Fusco DN, Zhao H, Goto K, Peng LF, Chen WC, Chung RT. IL28B inhibits hepatitis C virus replication through the JAK-STAT pathway. J Hepatol. 2011 Aug; 55(2):289-98.
    View in: PubMed
  66. Abu Dayyeh BK, Yang M, Dienstag JL, Chung RT. The effects of angiotensin blocking agents on the progression of liver fibrosis in the HALT-C Trial cohort. Dig Dis Sci. 2011 Feb; 56(2):564-8.
    View in: PubMed
  67. Lin W, Wu G, Li S, Weinberg EM, Kumthip K, Peng LF, Méndez-Navarro J, Chen WC, Jilg N, Zhao H, Goto K, Zhang L, Brockman MA, Schuppan D, Chung RT. HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB. J Biol Chem. 2011 Jan 28; 286(4):2665-74.
    View in: PubMed
  68. Han SH, Reddy KR, Keeffe EB, Soldevila-Pico C, Gish R, Chung RT, Degertekin B, Lok A. Clinical outcomes of liver transplantation for HBV-related hepatocellular carcinoma: data from the NIH HBV OLT study. Clin Transplant. 2011 Mar-Apr; 25(2):E152-62.
    View in: PubMed
  69. Chung RT, Poordad FF, Hassanein T, Zhou X, Lentz E, Prabhakar A, Di Bisceglie AM. Association of host pharmacodynamic effects with virologic response to pegylated interferon alfa-2a/ribavirin in chronic hepatitis C. Hepatology. 2010 Dec; 52(6):1906-14.
    View in: PubMed
  70. Jang JY, Shao RX, Lin W, Weinberg E, Chung WJ, Tsai WL, Zhao H, Goto K, Zhang L, Mendez-Navarro J, Jilg N, Peng LF, Brockman MA, Chung RT. HIV infection increases HCV-induced hepatocyte apoptosis. J Hepatol. 2011 Apr; 54(4):612-20.
    View in: PubMed
  71. Kim AY, Kuntzen T, Timm J, Nolan BE, Baca MA, Reyor LL, Berical AC, Feller AJ, Johnson KL, Schulze zur Wiesch J, Robbins GK, Chung RT, Walker BD, Carrington M, Allen TM, Lauer GM. Spontaneous control of HCV is associated with expression of HLA-B 57 and preservation of targeted epitopes. Gastroenterology. 2011 Feb; 140(2):686-696.e1.
    View in: PubMed
  72. Moriguchi H, Chung RT, Mihara M, Sato C. Generation of human induced pluripotent stem cells from liver progenitor cells by only small molecules. Hepatology. 2010 Sep; 52(3):1169; author reply 1169-70.
    View in: PubMed
  73. Jang JY, Chung RT. New treatments for chronic hepatitis C. Korean J Hepatol. 2010 Sep; 16(3):263-77.
    View in: PubMed
  74. Méndez-Navarro J, Corey KE, Zheng H, Barlow LL, Jang JY, Lin W, Zhao H, Shao RX, McAfee SL, Chung RT. Hepatitis B screening, prophylaxis and re-activation in the era of rituximab-based chemotherapy. Liver Int. 2011 Mar; 31(3):330-9.
    View in: PubMed
  75. Delgado-Borrego A, Healey D, Negre B, Christofi M, Sabharwal S, Ludwig DA, Chung RT, Jonas MM. Influence of body mass index on outcome of pediatric chronic hepatitis C virus infection. J Pediatr Gastroenterol Nutr. 2010 Aug; 51(2):191-7.
    View in: PubMed
  76. King LY, Chung RT. When treating cancer, please don't forget hepatitis B. Oncologist. 2010; 15(8):826-9.
    View in: PubMed
  77. Shao RX, Zhang L, Peng LF, Sun E, Chung WJ, Jang JY, Tsai WL, Hyppolite G, Chung RT. Suppressor of cytokine signaling 3 suppresses hepatitis C virus replication in an mTOR-dependent manner. J Virol. 2010 Jun; 84(12):6060-9.
    View in: PubMed
  78. Chung RT. Reaping the early harvest of the genomics revolution. Gastroenterology. 2010 May; 138(5):1653-4.
    View in: PubMed
  79. Tsai WL, Chung RT. Viral hepatocarcinogenesis. Oncogene. 2010 Apr 22; 29(16):2309-24.
    View in: PubMed
  80. Lin W, Tsai WL, Shao RX, Wu G, Peng LF, Barlow LL, Chung WJ, Zhang L, Zhao H, Jang JY, Chung RT. Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner. Gastroenterology. 2010 Jun; 138(7):2509-18, 2518.e1.
    View in: PubMed
  81. Sherman KE, Soriano V, Chung RT. Human immunodeficiency virus and liver disease: conference proceedings. Hepatology. 2010 Mar; 51(3):1046-54.
    View in: PubMed
  82. Moriguchi H, Chung RT, Sato C. An indicator for evaluating the risk of cancerous transformations of human induced pluripotent stem cells. Hepatology. 2010 Mar; 51(3):1085-6.
    View in: PubMed
  83. Moriguchi H, Chung RT, Sato C. Tumorigenicity of human induced pluripotent stem cells depends on the balance of gene expression between p21 and p53. Hepatology. 2010 Mar; 51(3):1088-9.
    View in: PubMed
  84. Sherman KE, Rouster SD, Stanford S, Blackard JT, Shire N, Koziel M, Peters M, Chung RT. Hepatitis C virus (HCV) quasispecies complexity and selection in HCV/HIV-coinfected subjects treated with interferon-based regimens. J Infect Dis. 2010 Mar; 201(5):712-9.
    View in: PubMed
  85. Moriguchi H, Chung RT, Sato C. An identification of novel therapy for human hepatocellular carcinoma by using human induced pluripotent stem cells. Hepatology. 2010 Mar; 51(3):1090-1.
    View in: PubMed
  86. Delgado-Borrego A, Jordan SH, Negre B, Healey D, Lin W, Kamegaya Y, Christofi M, Ludwig DA, Lok AS, Chung RT. Reduction of insulin resistance with effective clearance of hepatitis C infection: results from the HALT-C trial. Clin Gastroenterol Hepatol. 2010 May; 8(5):458-62.
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  88. Contreras AM, Ochoa-Jiménez RJ, Celis A, Méndez C, Olivares L, Rebolledo CE, Hernandez-Lugo I, Aguirre-Zavala AI, Jiménez-Méndez R, Chung RT. High antibody level: an accurate serologic marker of viremia in asymptomatic people with hepatitis C infection. Transfusion. 2010 Jun; 50(6):1335-43.
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  89. Moriguchi H, Chung RT, Sato C. New translational research on novel drugs for hepatitis C virus 1b infection by using a replicon system and human induced pluripotent stem cells. Hepatology. 2010 Jan; 51(1):344-5; author reply 345.
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  90. Moriguchi H, Chung RT, Sato C. An identification of the novel combination therapy for hepatitis C virus 1b infection by using a replicon system and human induced pluripotent stem cells. Hepatology. 2010 Jan; 51(1):351-2.
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  91. Schwarze-Zander C, Neibecker M, Othman S, Tural C, Clotet B, Blackard JT, Kupfer B, Luechters G, Chung RT, Rockstroh JK, Spengler U. GB virus C coinfection in advanced HIV type-1 disease is associated with low CCR5 and CXCR4 surface expression on CD4(+) T-cells. Antivir Ther. 2010; 15(5):745-52.
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  92. Méndez-Navarro J, Chirino RA, Corey KE, Gorospe EC, Zheng H, Morán S, Juarez JA, Chung RT, Dehesa-Violante M. A randomized controlled trial of double versus triple therapy with amantadine for genotype 1 chronic hepatitis C in Latino patients. Dig Dis Sci. 2010 Sep; 55(9):2629-35.
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  93. Schiødt FV, Chung RT, Schilsky ML, Hay JE, Christensen E, Lee WM. Outcome of acute liver failure in the elderly. Liver Transpl. 2009 Nov; 15(11):1481-7.
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  94. Corey KE, Servoss JC, Casson DR, Kim AY, Robbins GK, Franzini J, Twitchell K, Loomis SC, Abraczinskas DR, Terella AM, Dienstag JL, Chung RT. Pilot study of postexposure prophylaxis for hepatitis C virus in healthcare workers. Infect Control Hosp Epidemiol. 2009 Oct; 30(10):1000-5.
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  95. Corey KE, Kane E, Munroe C, Barlow LL, Zheng H, Chung RT. Hepatitis C virus infection and its clearance alter circulating lipids: implications for long-term follow-up. Hepatology. 2009 Oct; 50(4):1030-7.
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  96. McGovern BH, Birch CE, Bowen MJ, Reyor LL, Nagami EH, Chung RT, Kim AY. Improving the diagnosis of acute hepatitis C virus infection with expanded viral load criteria. Clin Infect Dis. 2009 Oct 1; 49(7):1051-60.
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  97. McGovern BH, Nagami EH, Birch CE, Bowen MJ, Reyor LL, Chung RT, Kim AY. Rate of sustained virologic response in relation to baseline hepatitis C virus (HCV) RNA level and rapid virologic clearance in persons with acute HCV infection. J Infect Dis. 2009 Sep 15; 200(6):877-81.
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  98. Corey KE, Mendez-Navarro J, Gorospe EC, Zheng H, Chung RT. Early treatment improves outcomes in acute hepatitis C virus infection: a meta-analysis. J Viral Hepat. 2010 Mar; 17(3):201-7.
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  99. Rodriguez-Torres M, Sulkowski MS, Chung RT, Hamzeh FM, Jensen DM. Factors associated with rapid and early virologic response to peginterferon alfa-2a/ribavirin treatment in HCV genotype 1 patients representative of the general chronic hepatitis C population. J Viral Hepat. 2010 Feb 1; 17(2):139-47.
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  100. Deshpande V, Sainani NI, Chung RT, Pratt DS, Mentha G, Rubbia-Brandt L, Lauwers GY. IgG4-associated cholangitis: a comparative histological and immunophenotypic study with primary sclerosing cholangitis on liver biopsy material. Mod Pathol. 2009 Oct; 22(10):1287-95.
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  101. Zúñiga J, Romero V, Azocar J, Terreros D, Vargas-Rojas MI, Torres-García D, Jiménez-Alvarez L, Vargas-Alarcón G, Granados-Montiel J, Husain Z, Chung RT, Alper CA, Yunis EJ. Protective KIR-HLA interactions for HCV infection in intravenous drug users. Mol Immunol. 2009 Aug; 46(13):2723-7.
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  102. Kim AY, Chung RT. Coinfection with HIV-1 and HCV--a one-two punch. Gastroenterology. 2009 Sep; 137(3):795-814.
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  103. Lok AS, Everhart JE, Chung RT, Kim HY, Everson GT, Hoefs JC, Greenson JK, Sterling RK, Lindsay KL, Lee WM, Di Bisceglie AM, Bonkovsky HL, Ghany MG, Morishima C. Evolution of hepatic steatosis in patients with advanced hepatitis C: results from the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial. Hepatology. 2009 Jun; 49(6):1828-37.
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  104. Nelson AL, Millington TM, Sahani D, Chung RT, Bauer C, Hertl M, Warshaw AL, Conrad C. Hepatic portal venous gas: the ABCs of management. Arch Surg. 2009 Jun; 144(6):575-81; discussion 581.
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  105. Welzel TM, Morgan TR, Bonkovsky HL, Naishadham D, Pfeiffer RM, Wright EC, Hutchinson AA, Crenshaw AT, Bashirova A, Carrington M, Dotrang M, Sterling RK, Lindsay KL, Fontana RJ, Lee WM, Di Bisceglie AM, Ghany MG, Gretch DR, Chanock SJ, Chung RT, O'Brien TR. Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial. Hepatology. 2009 Jun; 49(6):1847-58.
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  106. Everhart JE, Lok AS, Kim HY, Morgan TR, Lindsay KL, Chung RT, Bonkovsky HL, Ghany MG. Weight-related effects on disease progression in the hepatitis C antiviral long-term treatment against cirrhosis trial. Gastroenterology. 2009 Aug; 137(2):549-57.
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  107. Zhao HT, Endo S, Ishikura S, Chung R, Hogg PJ, Hara A, El-Kabbani O. Structure/function analysis of a critical disulfide bond in the active site of L-xylulose reductase. Cell Mol Life Sci. 2009 May; 66(9):1570-9.
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  108. Andersson KL, Chung RT. Monitoring during and after antiviral therapy for hepatitis B. Hepatology. 2009 May; 49(5 Suppl):S166-73.
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  109. Tai AW, Chung RT. Racial differences in response to interferon-based antiviral therapy for hepatitis C virus infection: a hardwiring issue? J Infect Dis. 2009 Apr 15; 199(8):1101-3.
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  110. Tai AW, Benita Y, Peng LF, Kim SS, Sakamoto N, Xavier RJ, Chung RT. A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe. 2009 Mar 19; 5(3):298-307.
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  111. Kim KA, Lin W, Tai AW, Shao RX, Weinberg E, De Sa Borges CB, Bhan AK, Zheng H, Kamegaya Y, Chung RT. Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection. J Hepatol. 2009 Apr; 50(4):705-11.
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  112. Corey KE, Shah N, Misdraji J, Abu Dayyeh BK, Zheng H, Bhan AK, Chung RT. The effect of angiotensin-blocking agents on liver fibrosis in patients with hepatitis C. Liver Int. 2009 May; 29(5):748-53.
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  113. Shire NJ, Rao MB, Succop P, Buncher CR, Andersen JA, Butt AA, Chung RT, Sherman KE. Improving noninvasive methods of assessing liver fibrosis in patients with hepatitis C virus/human immunodeficiency virus co-infection. Clin Gastroenterol Hepatol. 2009 Apr; 7(4):471-80, 480.e1-2.
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  114. Tai AW, Chung RT. Treatment failure in hepatitis C: mechanisms of non-response. J Hepatol. 2009 Feb; 50(2):412-20.
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  115. Kuntzen T, Timm J, Berical A, Lennon N, Berlin AM, Young SK, Lee B, Heckerman D, Carlson J, Reyor LL, Kleyman M, McMahon CM, Birch C, Schulze Zur Wiesch J, Ledlie T, Koehrsen M, Kodira C, Roberts AD, Lauer GM, Rosen HR, Bihl F, Cerny A, Spengler U, Liu Z, Kim AY, Xing Y, Schneidewind A, Madey MA, Fleckenstein JF, Park VM, Galagan JE, Nusbaum C, Walker BD, Lake-Bakaar GV, Daar ES, Jacobson IM, Gomperts ED, Edlin BR, Donfield SM, Chung RT, Talal AH, Marion T, Birren BW, Henn MR, Allen TM. Naturally occurring dominant resistance mutations to hepatitis C virus protease and polymerase inhibitors in treatment-naïve patients. Hepatology. 2008 Dec; 48(6):1769-78.
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  116. McGovern BH, Abu Dayyeh BK, Chung RT. Avoiding therapeutic pitfalls: the rational use of specifically targeted agents against hepatitis C infection. Hepatology. 2008 Nov; 48(5):1700-12.
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  117. Sabharwal S, Delgado-Borrego A, Chung RT. Extrahepatic hepatitis C virus after transplantation: diabetes and renal dysfunction. Liver Transpl. 2008 Oct; 14 Suppl 2:S51-7.
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  118. Miller JC, Hahn PF, Chung RT, Thrall JH, Lee SI. Screening for hepatocellular carcinoma in cirrhotic patients. J Am Coll Radiol. 2008 Sep; 5(9):1012-4.
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  119. Andersson KL, Salomon JA, Goldie SJ, Chung RT. Cost effectiveness of alternative surveillance strategies for hepatocellular carcinoma in patients with cirrhosis. Clin Gastroenterol Hepatol. 2008 Dec; 6(12):1418-24.
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  120. Martin NM, Abu Dayyeh BK, Chung RT. Anabolic steroid abuse causing recurrent hepatic adenomas and hemorrhage. World J Gastroenterol. 2008 Jul 28; 14(28):4573-5.
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  121. Hiasa Y, Kuzuhara H, Tokumoto Y, Konishi I, Yamashita N, Matsuura B, Michitaka K, Chung RT, Onji M. Hepatitis C virus replication is inhibited by 22beta-methoxyolean-12-ene-3beta, 24(4beta)-diol (ME3738) through enhancing interferon-beta. Hepatology. 2008 Jul; 48(1):59-69.
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  122. Morgan TR, Lambrecht RW, Bonkovsky HL, Chung RT, Naishadham D, Sterling RK, Fontana RJ, Lee WM, Ghany MG, Wright EC, O'Brien TR. DNA polymorphisms and response to treatment in patients with chronic hepatitis C: results from the HALT-C trial. J Hepatol. 2008 Oct; 49(4):548-56.
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  123. Abu Dayyeh BK, Chung RT. Broadly neutralizing antibodies against hepatitis C virus: new hope for immunization? Gastroenterology. 2008 Jun; 134(7):2184-6.
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  124. Rutherford A, Chung RT. Acute liver failure: mechanisms of hepatocyte injury and regeneration. Semin Liver Dis. 2008 May; 28(2):167-74.
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  125. Nahmias Y, Goldwasser J, Casali M, van Poll D, Wakita T, Chung RT, Yarmush ML. Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin. Hepatology. 2008 May; 47(5):1437-45.
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  126. Swan T, Chung RT. Development of novel agents for the treatment of hepatitis C virus. Hepatology. 2008 Apr; 47(4):1426.
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  127. Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood. 2008 May 15; 111(10):5195-204.
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  128. Romero V, Azocar J, Zúñiga J, Clavijo OP, Terreros D, Gu X, Husain Z, Chung RT, Amos C, Yunis EJ. Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome. Mol Immunol. 2008 May; 45(9):2429-36.
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  129. Delgado-Borrego A, Liu YS, Jordan SH, Agrawal S, Zhang H, Christofi M, Casson D, Cosimi AB, Chung RT. Prospective study of liver transplant recipients with HCV infection: evidence for a causal relationship between HCV and insulin resistance. Liver Transpl. 2008 Feb; 14(2):193-201.
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  130. Lin W, Weinberg EM, Tai AW, Peng LF, Brockman MA, Kim KA, Kim SS, Borges CB, Shao RX, Chung RT. HIV increases HCV replication in a TGF-beta1-dependent manner. Gastroenterology. 2008 Mar; 134(3):803-11.
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  131. Tanabe KK, Lemoine A, Finkelstein DM, Kawasaki H, Fujii T, Chung RT, Lauwers GY, Kulu Y, Muzikansky A, Kuruppu D, Lanuti M, Goodwin JM, Azoulay D, Fuchs BC. Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis. JAMA. 2008 Jan 2; 299(1):53-60.
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  132. O'Leary JG, Zachary K, Misdraji J, Chung RT. De novo autoimmune hepatitis during immune reconstitution in an HIV-infected patient receiving highly active antiretroviral therapy. Clin Infect Dis. 2008 Jan 1; 46(1):e12-4.
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  133. Chung RT, Gale M, Polyak SJ, Lemon SM, Liang TJ, Hoofnagle JH. Mechanisms of action of interferon and ribavirin in chronic hepatitis C: Summary of a workshop. Hepatology. 2008 Jan; 47(1):306-20.
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  134. Kasprowicz V, Schulze Zur Wiesch J, Kuntzen T, Nolan BE, Longworth S, Berical A, Blum J, McMahon C, Reyor LL, Elias N, Kwok WW, McGovern BG, Freeman G, Chung RT, Klenerman P, Lewis-Ximenez L, Walker BD, Allen TM, Kim AY, Lauer GM. High level of PD-1 expression on hepatitis C virus (HCV)-specific CD8+ and CD4+ T cells during acute HCV infection, irrespective of clinical outcome. J Virol. 2008 Mar; 82(6):3154-60.
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  135. Andersson KL, Chung RT. Hepatic schistosomiasis. Curr Treat Options Gastroenterol. 2007 Dec; 10(6):504-12.
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  136. Corey KE, Chung RT. Treating difficult-to-treat hepatitis C virus infection: we may still need to push the ribavirin envelope. Gastroenterology. 2007 Dec; 133(6):2062-3.
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  137. Kim AY, Chung RT. Sex, drugs, and hepatitis C virus in men who have sex with men: evidence for permucosal transmission. Gastroenterology. 2007 Nov; 133(5):1734-6; discussion 1736-7.
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  138. Kang M, Chung RT. The role of early viral decline in the treatment of hepatitis C in HIV-1-coinfected persons. J Acquir Immune Defic Syndr. 2007 Nov 1; 46(3):371-3.
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  139. Rutherford AE, Hynan LS, Borges CB, Forcione DG, Blackard JT, Lin W, Gorman AR, Shaikh OS, Reuben A, Harrison E, Reddy KR, Le WM, Chung RT. Serum apoptosis markers in acute liver failure: a pilot study. Clin Gastroenterol Hepatol. 2007 Dec; 5(12):1477-83.
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  140. Tai AW, Chung RT. The hepatitis C virus plot thickens: enter claudin-1. Gastroenterology. 2007 Sep; 133(3):1041-2.
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  141. Kuntzen T, Timm J, Berical A, Lewis-Ximenez LL, Jones A, Nolan B, Schulze zur Wiesch J, Li B, Schneidewind A, Kim AY, Chung RT, Lauer GM, Allen TM. Viral sequence evolution in acute hepatitis C virus infection. J Virol. 2007 Nov; 81(21):11658-68.
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  142. Peng LF, Kim SS, Matchacheep S, Lei X, Su S, Lin W, Runguphan W, Choe WH, Sakamoto N, Ikeda M, Kato N, Beeler AB, Porco JA, Schreiber SL, Chung RT. Identification of novel epoxide inhibitors of hepatitis C virus replication using a high-throughput screen. Antimicrob Agents Chemother. 2007 Oct; 51(10):3756-9.
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  143. Tokumoto Y, Hiasa Y, Horiike N, Michitaka K, Matsuura B, Chung RT, Onji M. Hepatitis C virus expression and interferon antiviral action is dependent on PKR expression. J Med Virol. 2007 Aug; 79(8):1120-7.
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  144. Timm J, Li B, Daniels MG, Bhattacharya T, Reyor LL, Allgaier R, Kuntzen T, Fischer W, Nolan BE, Duncan J, Schulze zur Wiesch J, Kim AY, Frahm N, Brander C, Chung RT, Lauer GM, Korber BT, Allen TM. Human leukocyte antigen-associated sequence polymorphisms in hepatitis C virus reveal reproducible immune responses and constraints on viral evolution. Hepatology. 2007 Aug; 46(2):339-49.
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  145. Tai AW, Chung RT. p53 restoration leads to tumor senescence and regression: implications for cancer therapy. Gastroenterology. 2007 Aug; 133(2):722-3.
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  146. Aweeka FT, Kang M, Yu JY, Lizak P, Alston B, Chung RT. Pharmacokinetic evaluation of the effects of ribavirin on zidovudine triphosphate formation: ACTG 5092s Study Team. HIV Med. 2007 Jul; 8(5):288-94.
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  147. Pekow JR, Bhan AK, Zheng H, Chung RT. Hepatic steatosis is associated with increased frequency of hepatocellular carcinoma in patients with hepatitis C-related cirrhosis. Cancer. 2007 Jun 15; 109(12):2490-6.
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  148. Blackard JT, Hiasa Y, Smeaton L, Jamieson DJ, Rodriguez I, Mayer KH, Chung RT. Compartmentalization of hepatitis C virus (HCV) during HCV/HIV coinfection. J Infect Dis. 2007 Jun 15; 195(12):1765-73.
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  149. Schulze Zur Wiesch J, Lauer GM, Timm J, Kuntzen T, Neukamm M, Berical A, Jones AM, Nolan BE, Longworth SA, Kasprowicz V, McMahon C, Wurcel A, Lohse AW, Lewis-Ximenez LL, Chung RT, Kim AY, Allen TM, Walker BD. Immunologic evidence for lack of heterologous protection following resolution of HCV in patients with non-genotype 1 infection. Blood. 2007 Sep 1; 110(5):1559-69.
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  150. Timm J, Neukamm M, Kuntzen T, Kim AY, Chung RT, Brander C, Lauer GM, Walker BD, Allen TM. Characterization of full-length hepatitis C virus genotype 4 sequences. J Viral Hepat. 2007 May; 14(5):330-7.
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  151. Behler CM, Vittinghoff E, Lin F, Chung RT, Peters MG, Robbins GK, Volberding PA. Hematologic toxicity associated with interferon-based hepatitis C therapy in HIV type 1-coinfected subjects. Clin Infect Dis. 2007 May 15; 44(10):1375-83.
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  152. Lauer GM, Chung RT. Vaccine-induced T-cell responses against HCV: one step taken, more to follow. Gastroenterology. 2007 Apr; 132(4):1626-8.
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  153. O'Leary JG, Chan JL, McMahon CM, Chung RT. Atorvastatin does not exhibit antiviral activity against HCV at conventional doses: a pilot clinical trial. Hepatology. 2007 Apr; 45(4):895-8.
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  154. Blackard JT, Kang M, St Clair JB, Lin W, Kamegaya Y, Sherman KE, Koziel MJ, Peters MG, Andersen J, Chung RT. Viral factors associated with cytokine expression during HCV/HIV co-infection. J Interferon Cytokine Res. 2007 Apr; 27(4):263-9.
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  155. Billington J, Hickling TP, Munro GH, Halai C, Chung R, Dodson GG, Daniels RS. Stability of a receptor-binding active human immunodeficiency virus type 1 recombinant gp140 trimer conferred by intermonomer disulfide bonding of the V3 loop: differential effects of protein disulfide isomerase on CD4 and coreceptor binding. J Virol. 2007 May; 81(9):4604-14.
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  157. Lok AS, Everhart JE, Chung RT, Padmanabhan L, Greenson JK, Shiffman ML, Everson GT, Lindsay KL, Bonkovsky HL, Di Bisceglie AM, Lee WM, Morgan TR, Ghany MG, Morishima C. Hepatic steatosis in hepatitis C: comparison of diabetic and nondiabetic patients in the hepatitis C antiviral long-term treatment against cirrhosis trial. Clin Gastroenterol Hepatol. 2007 Feb; 5(2):245-54.
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  158. Kim AY, Schulze zur Wiesch J, Kuntzen T, Timm J, Kaufmann DE, Duncan JE, Jones AM, Wurcel AG, Davis BT, Gandhi RT, Robbins GK, Allen TM, Chung RT, Lauer GM, Walker BD. Impaired hepatitis C virus-specific T cell responses and recurrent hepatitis C virus in HIV coinfection. PLoS Med. 2006 Dec; 3(12):e492.
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  159. Andrade-Sierra J, Contreras AM, Monteon FJ, Celis A, Gutierrez R, Montañez JL, Ruelas S, Baid-Agrawal S, Chung RT. Risk factors and incidence of posttransplant diabetes mellitus in Mexican kidney recipients. Arch Med Res. 2006 Nov; 37(8):961-6.
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  160. Servoss JC, Kitch DW, Andersen JW, Reisler RB, Chung RT, Robbins GK. Predictors of antiretroviral-related hepatotoxicity in the adult AIDS Clinical Trial Group (1989-1999). J Acquir Immune Defic Syndr. 2006 Nov 1; 43(3):320-3.
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  161. Blackard JT, Kang M, Sherman KE, Koziel MJ, Peters MG, Chung RT. Effects of HCV treatment on cytokine expression during HCV/HIV coinfection. J Interferon Cytokine Res. 2006 Nov; 26(11):834-8.
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  162. Chung RT, Misdraji J, Sahani DV. Case records of the Massachusetts General Hospital. Case 33-2006. A 43-year-old man with diabetes, hypogonadism, cirrhosis, arthralgias, and fatigue. N Engl J Med. 2006 Oct 26; 355(17):1812-9.
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  163. Kim SS, Peng LF, Lin W, Choe WH, Sakamoto N, Kato N, Ikeda M, Schreiber SL, Chung RT. A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication. Gastroenterology. 2007 Jan; 132(1):311-20.
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  164. Rutherford A, Davern T, Hay JE, Murray NG, Hassanein T, Lee WM, Chung RT. Influence of high body mass index on outcome in acute liver failure. Clin Gastroenterol Hepatol. 2006 Dec; 4(12):1544-9.
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  165. Lin W, Kim SS, Yeung E, Kamegaya Y, Blackard JT, Kim KA, Holtzman MJ, Chung RT. Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain. J Virol. 2006 Sep; 80(18):9226-35.
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  166. Corey KE, Ross AS, Wurcel A, Schulze Zur Wiesch J, Kim AY, Lauer GM, Chung RT. Outcomes and treatment of acute hepatitis C virus infection in a United States population. Clin Gastroenterol Hepatol. 2006 Oct; 4(10):1278-82.
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  167. Bonkovsky HL, Naishadham D, Lambrecht RW, Chung RT, Hoefs JC, Nash SR, Rogers TE, Banner BF, Sterling RK, Donovan JA, Fontana RJ, Di Bisceglie AM, Ghany MG, Morishima C. Roles of iron and HFE mutations on severity and response to therapy during retreatment of advanced chronic hepatitis C. Gastroenterology. 2006 Nov; 131(5):1440-51.
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  168. Schwarze-Zander C, Blackard JT, Zheng H, Addo MM, Lin W, Robbins GK, Sherman KE, Zdunek D, Hess G, Chung RT. GB virus C (GBV-C) infection in hepatitis C virus (HCV)/HIV-coinfected patients receiving HCV treatment: importance of the GBV-C genotype. J Infect Dis. 2006 Aug 15; 194(4):410-9.
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  169. Basavapathruni A, Vingerhoets J, de Béthune MP, Chung R, Bailey CM, Kim J, Anderson KS. Modulation of human immunodeficiency virus type 1 synergistic inhibition by reverse transcriptase mutations. Biochemistry. 2006 Jun 13; 45(23):7334-40.
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  170. O'Leary JG, Chung RT. Management of hepatitis C virus coinfection in HIV-infected persons. AIDS Read. 2006 Jun; 16(6):313-6, 318-20.
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  171. Chung RT. Hepatitis C and B viruses: the new opportunists in HIV infection. Top HIV Med. 2006 Jun-Jul; 14(2):78-83.
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  172. Chung RT, Iafrate AJ, Amrein PC, Sahani DV, Misdraji J. Case records of the Massachusetts General Hospital. Case 15-2006. A 46-year-old woman with sudden onset of abdominal distention. N Engl J Med. 2006 May 18; 354(20):2166-75.
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  173. Andersson K, Chung RT. Hepatitis C Virus in the HIV-infected patient. Clin Liver Dis. 2006 May; 10(2):303-20, viii.
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  174. Pekow J, Chung RT. Treatment of type II cryoglobulinemia associated with hepatitis C with rituximab. J Clin Gastroenterol. 2006 May-Jun; 40(5):450.
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  175. Fontana RJ, Sanyal AJ, Mehta S, Doherty MC, Neuschwander-Tetri BA, Everson GT, Kahn JA, Malet PF, Sheikh MY, Chung RT, Ghany MG, Gretch DR. Portal hypertensive gastropathy in chronic hepatitis C patients with bridging fibrosis and compensated cirrhosis: results from the HALT-C trial. Am J Gastroenterol. 2006 May; 101(5):983-92.
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  176. Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006 May; 38(5):531-9.
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  177. Graham CS, Wells A, Liu T, Sherman KE, Peters M, Chung RT, Bhan AK, Andersen J, Koziel MJ. Relationships between cellular immune responses and treatment outcomes with interferon and ribavirin in HIV/hepatitis C virus co-infection. AIDS. 2006 Feb 14; 20(3):345-51.
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  178. Blackard JT, Komurian-Pradel F, Perret M, Sodoyer M, Smeaton L, St Clair JB, Chapman S, Taylor LE, Paranhos-Baccalà G, Chung RT. Intrahepatic cytokine expression is downregulated during HCV/HIV co-infection. J Med Virol. 2006 Feb; 78(2):202-7.
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  179. Kotton CN, Marconi VC, Fishman JA, Chung RT, Elias N, Hertl M. Coccidioidal meningitis after liver transplantation in a nonendemic region: a case report. Transplantation. 2006 Jan 15; 81(1):132-4.
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  180. Yeung E, Chung RT. Microarrays and prediction of interferon response in chronic hepatitis C: not yet ready for prime time. Clin Gastroenterol Hepatol. 2005 Dec; 3(12):1192-4.
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  181. Schiano TD, Gutierrez JA, Walewski JL, Fiel MI, Cheng B, Bodenheimer H, Thung SN, Chung RT, Schwartz ME, Bodian C, Branch AD. Accelerated hepatitis C virus kinetics but similar survival rates in recipients of liver grafts from living versus deceased donors. Hepatology. 2005 Dec; 42(6):1420-8.
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  182. McGuire BM, Bonkovsky HL, Carithers RL, Chung RT, Goldstein LI, Lake JR, Lok AS, Potter CJ, Rand E, Voigt MD, Davis PR, Bloomer JR. Liver transplantation for erythropoietic protoporphyria liver disease. Liver Transpl. 2005 Dec; 11(12):1590-6.
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  183. Chung RT. Assessment of efficacy of treatment in HCV: infection and disease. J Hepatol. 2006; 44(1 Suppl):S56-9.
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  184. Hiasa Y, Blackard JT, Lin W, Kamegaya Y, Horiike N, Onji M, Schmidt EV, Chung RT. Cell-based models of sustained, interferon-sensitive hepatitis C virus genotype 1 replication. J Virol Methods. 2006 Mar; 132(1-2):195-203.
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  185. Morgan L, Neame SJ, Child H, Chung R, Shah B, Barden L, Staddon JM, Patel TR. Development of a pentylenetetrazole-induced seizure model to evaluate kinase inhibitor efficacy in the central nervous system. Neurosci Lett. 2006 Mar 6; 395(2):143-8.
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  186. Schiødt FV, Rossaro L, Stravitz RT, Shakil AO, Chung RT, Lee WM. Gc-globulin and prognosis in acute liver failure. Liver Transpl. 2005 Oct; 11(10):1223-7.
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  187. Lauer GM, Lucas M, Timm J, Ouchi K, Kim AY, Day CL, Schulze Zur Wiesch J, Paranhos-Baccala G, Sheridan I, Casson DR, Reiser M, Gandhi RT, Li B, Allen TM, Chung RT, Klenerman P, Walker BD. Full-breadth analysis of CD8+ T-cell responses in acute hepatitis C virus infection and early therapy. J Virol. 2005 Oct; 79(20):12979-88.
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  188. Sekhon JS, Chung RT, Epstein M, Kaplan MM. Steroid-responsive (autoimmune?) sclerosing cholangitis. Dig Dis Sci. 2005 Oct; 50(10):1839-43.
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  189. Schulze zur Wiesch J, Lauer GM, Day CL, Kim AY, Ouchi K, Duncan JE, Wurcel AG, Timm J, Jones AM, Mothe B, Allen TM, McGovern B, Lewis-Ximenez L, Sidney J, Sette A, Chung RT, Walker BD. Broad repertoire of the CD4+ Th cell response in spontaneously controlled hepatitis C virus infection includes dominant and highly promiscuous epitopes. J Immunol. 2005 Sep 15; 175(6):3603-13.
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  190. Di Bisceglie AM, Sterling RK, Chung RT, Everhart JE, Dienstag JL, Bonkovsky HL, Wright EC, Everson GT, Lindsay KL, Lok AS, Lee WM, Morgan TR, Ghany MG, Gretch DR. Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C Trial. J Hepatol. 2005 Sep; 43(3):434-41.
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  191. Yeung E, Chung RT. Rethinking hepatitis C viral kinetics: Insights into host-virus interactions in 'difficult-to-treat' groups and implications for novel treatment approaches. J Hepatol. 2005 Nov; 43(5):748-50.
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  192. Tanabe KK, Blaszkowsky LS, Chung RT, Blake MA, Lauwers GY. Case records of the Massachusetts General Hospital. Case 23-2005. A 57-year-old man with a mass in the liver. N Engl J Med. 2005 Jul 28; 353(4):401-10.
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  193. Chung RT. Acute hepatitis C virus infection. Clin Infect Dis. 2005 Jul 1; 41 Suppl 1:S14-7.
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  194. Yachimski P, Chung RT. Update on Hepatitis B and C Coinfection in HIV. Curr Infect Dis Rep. 2005 Jul; 7(4):299-308.
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  195. Blackard JT, Smeaton L, Hiasa Y, Horiike N, Onji M, Jamieson DJ, Rodriguez I, Mayer KH, Chung RT. Detection of hepatitis C virus (HCV) in serum and peripheral-blood mononuclear cells from HCV-monoinfected and HIV/HCV-coinfected persons. J Infect Dis. 2005 Jul 15; 192(2):258-65.
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  196. Graham CS, Wells A, Liu T, Sherman KE, Peters M, Chung RT, Bhan AK, Andersen J, Koziel MJ. Antigen-specific immune responses and liver histology in HIV and hepatitis C coinfection. AIDS. 2005 May 20; 19(8):767-73.
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  197. Yachimski P, Chung RT. Hepatitis B virus infection in liver transplant candidates and recipients. MedGenMed. 2005; 7(2):20.
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  198. Lin W, Choe WH, Hiasa Y, Kamegaya Y, Blackard JT, Schmidt EV, Chung RT. Hepatitis C virus expression suppresses interferon signaling by degrading STAT1. Gastroenterology. 2005 Apr; 128(4):1034-41.
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  199. Kamegaya Y, Hiasa Y, Zukerberg L, Fowler N, Blackard JT, Lin W, Choe WH, Schmidt EV, Chung RT. Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis. Hepatology. 2005 Mar; 41(3):660-7.
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  200. Chung RT. Cytokine polymorphisms and hepatocellular carcinoma: to B or not to B. Cancer. 2005 Feb 15; 103(4):654-6.
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  201. Sherman KE, Shire NJ, Rouster SD, Peters MG, James Koziel M, Chung RT, Horn PS. Viral kinetics in hepatitis C or hepatitis C/human immunodeficiency virus-infected patients. Gastroenterology. 2005 Feb; 128(2):313-27.
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  202. Eichbaum QG, Dzik WH, Chung RT, Szczepiorkowski ZM. Red blood cell exchange transfusion in two patients with advanced erythropoietic protoporphyria. Transfusion. 2005 Feb; 45(2):208-13.
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  203. Yeo H, Li Y, Fu L, Zhu JL, Gullen EA, Dutschman GE, Lee Y, Chung R, Huang ES, Austin DJ, Cheng YC. Synthesis and antiviral activity of helioxanthin analogues. J Med Chem. 2005 Jan 27; 48(2):534-46.
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  204. Hoehne F, Ozaeta M, Chung R. Routine chest X-ray after percutaneous tracheostomy is unnecessary. Am Surg. 2005 Jan; 71(1):51-3.
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  205. Torriani FJ, Chung RT. Peginterferon alpha-2a improved the hepatitis C virologic response in concurrent HIV and chronic hepatitis C virus infections. ACP J Club. 2005 Jan-Feb; 142(1):A12; author reply A13.
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  206. Timm J, Lauer GM, Kavanagh DG, Sheridan I, Kim AY, Lucas M, Pillay T, Ouchi K, Reyor LL, Schulze zur Wiesch J, Gandhi RT, Chung RT, Bhardwaj N, Klenerman P, Walker BD, Allen TM. CD8 epitope escape and reversion in acute HCV infection. J Exp Med. 2004 Dec 20; 200(12):1593-604.
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  207. Leung JY, Zhu AX, Gordon FD, Pratt DS, Mithoefer A, Garrigan K, Terella A, Hertl M, Cosimi AB, Chung RT. Liver transplantation outcomes for early-stage hepatocellular carcinoma: results of a multicenter study. Liver Transpl. 2004 Nov; 10(11):1343-54.
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  208. Yachimski P, Chung RT. Editorial comment: erythropoietin for treatment-related anemia in persons with hepatitis C--questions remain. AIDS Read. 2004 Oct; 14(10):568-9.
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  209. Kim AY, Lauer GM, Ouchi K, Addo MM, Lucas M, Schulze Zur Wiesch J, Timm J, Boczanowski M, Duncan JE, Wurcel AG, Casson D, Chung RT, Draenert R, Klenerman P, Walker BD. The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1. Blood. 2005 Feb 1; 105(3):1170-8.
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  210. Lauer GM, Barnes E, Lucas M, Timm J, Ouchi K, Kim AY, Day CL, Robbins GK, Casson DR, Reiser M, Dusheiko G, Allen TM, Chung RT, Walker BD, Klenerman P. High resolution analysis of cellular immune responses in resolved and persistent hepatitis C virus infection. Gastroenterology. 2004 Sep; 127(3):924-36.
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  211. Cardarelli F, Pascual M, Chung RT, Tolkoff-Rubin N, Wong W, Cosimi AB, Saidman SL. Interferon-alpha therapy in liver transplant recipients: lack of association with increased production of anti-HLA antibodies. Am J Transplant. 2004 Aug; 4(8):1352-6.
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  212. Chung RT, Andersen J, Volberding P, Robbins GK, Liu T, Sherman KE, Peters MG, Koziel MJ, Bhan AK, Alston B, Colquhoun D, Nevin T, Harb G, van der Horst C. Peginterferon Alfa-2a plus ribavirin versus interferon alfa-2a plus ribavirin for chronic hepatitis C in HIV-coinfected persons. N Engl J Med. 2004 Jul 29; 351(5):451-9.
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  213. Ross AS, Bhan AK, Pascual M, Thiim M, Benedict Cosimi A, Chung RT. Pegylated interferon alpha-2b plus ribavirin in the treatment of post-liver transplant recurrent hepatitis C. Clin Transplant. 2004 Apr; 18(2):166-73.
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  214. O'Leary J, Chung RT. New antiviral therapies for hepatitis C. Expert Rev Anti Infect Ther. 2004 Apr; 2(2):235-43.
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  215. Blackard JT, Yang Y, Bordoni P, Sherman KE, Chung RT. Hepatitis C virus (HCV) diversity in HIV-HCV-coinfected subjects initiating highly active antiretroviral therapy. J Infect Dis. 2004 Apr 15; 189(8):1472-81.
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  216. Delgado-Borrego A, Casson D, Schoenfeld D, Somsouk M, Terella A, Jordan SH, Bhan A, Baid S, Cosimi AB, Pascual M, Chung RT. Hepatitis C virus is independently associated with increased insulin resistance after liver transplantation. Transplantation. 2004 Mar 15; 77(5):703-10.
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  217. Kuo A, Dienstag JL, Chung RT. Tenofovir disoproxil fumarate for the treatment of lamivudine-resistant hepatitis B. Clin Gastroenterol Hepatol. 2004 Mar; 2(3):266-72.
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  218. Chung RT, Casson DR, Murray G, Song S, Grinspoon S, Hadigan C. Alanine aminotransferase levels predict insulin resistance in HIV lipodystrophy. J Acquir Immune Defic Syndr. 2003 Dec 15; 34(5):534-6.
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  219. O'Leary J, Chung RT. New antiviral therapies for hepatitis C. Taehan Kan Hakhoe Chi. 2003 Dec; 9(4):265-74.
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  220. Hiasa Y, Kamegaya Y, Nuriya H, Onji M, Kohara M, Schmidt EV, Chung RT. Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma. Am J Gastroenterol. 2003 Nov; 98(11):2528-34.
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  221. Moriguchi H, Chung RT, Contreras AM, Izumi N, Uemura T, Kobayashi M, Sato C. The interferon sensitivity determining region in the era of combination therapies and the rational use of such therapies for patients with HCV genotype 1b infection. Gastroenterology. 2003 Oct; 125(4):1284-6.
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  222. Day CL, Seth NP, Lucas M, Appel H, Gauthier L, Lauer GM, Robbins GK, Szczepiorkowski ZM, Casson DR, Chung RT, Bell S, Harcourt G, Walker BD, Klenerman P, Wucherpfennig KW. Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. J Clin Invest. 2003 Sep; 112(6):831-42.
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  223. Zhu AX, Chung RT. Hepatic steatosis in patients with chronic hepatitis C virus infection. Another risk factor for hepatocellular carcinoma? Cancer. 2003 Jun 15; 97(12):2948-50.
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  224. Somsouk M, Lauer GM, Casson D, Terella A, Day CL, Walker BD, Chung RT. Spontaneous resolution of chronic hepatitis C virus disease after withdrawal of immunosuppression. Gastroenterology. 2003 Jun; 124(7):1946-9.
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  225. Leung JY, Abraczinskas DR, Bhan AK, Terella AM, Pascual M, Cosimi AB, Chung RT. Recurrent allograft HCV presenting as acute cellular rejection: successful management with interferon and ribavirin alone. Clin Transplant. 2003 Jun; 17(3):275-83.
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  226. Glehen O, Mithieux F, Traverse-Glehen A, Isaac S, Bienvenu J, François Y, Chung R, Gilly FN. Enteral immunotherapy in the treatment of chronic enterocolitis in interleukin-10-deficient mice. Hepatogastroenterology. 2003 May-Jun; 50(51):670-5.
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  227. Moriguchi H, Kobayashi M, Chung RT, Sato C. Optimal IFN therapy for 40-year-old patients with severe HCV-1b infection. Gastroenterology. 2003 Apr; 124(4):1166-7.
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  228. Baid S, Tolkoff-Rubin N, Saidman S, Chung R, Williams WW, Auchincloss H, Colvin RB, Delmonico FL, Cosimi AB, Pascual M. Acute humoral rejection in hepatitis C-infected renal transplant recipients receiving antiviral therapy. Am J Transplant. 2003 Jan; 3(1):74-8.
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  229. Sikaneta T, Williams WW, Chung RT, Cosimi AB, Pascual AM. Remission of hepatitis C virus-associated cryoglobulinemic glomerulonephritis with interferon alfa-2b and ribavirin combination therapy after liver transplantation. Transplantation. 2002 Dec 27; 74(12):1767-8.
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  230. Goessling W, Chung RT. Amebic Liver Abscess. Curr Treat Options Gastroenterol. 2002 Dec; 5(6):443-449.
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  231. Day CL, Lauer GM, Robbins GK, McGovern B, Wurcel AG, Gandhi RT, Chung RT, Walker BD. Broad specificity of virus-specific CD4+ T-helper-cell responses in resolved hepatitis C virus infection. J Virol. 2002 Dec; 76(24):12584-95.
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  232. Contreras AM, Chung RT. Hepatitis C virus in solid organ transplantation: not always a bad thing? Gastroenterology. 2002 Nov; 123(5):1729-33.
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  233. Chung RT, Evans SR, Yang Y, Theodore D, Valdez H, Clark R, Shikuma C, Nevin T, Sherman KE. Immune recovery is associated with persistent rise in hepatitis C virus RNA, infrequent liver test flares, and is not impaired by hepatitis C virus in co-infected subjects. AIDS. 2002 Sep 27; 16(14):1915-23.
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  234. Chung RT. New developments in the management of hepatitis B virus/HIV coinfection. MedGenMed. 2002 Sep 3; 4(3):20.
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  235. Contreras AM, Hiasa Y, He W, Terella A, Schmidt EV, Chung RT. Viral RNA mutations are region specific and increased by ribavirin in a full-length hepatitis C virus replication system. J Virol. 2002 Sep; 76(17):8505-17.
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  236. Moriguchi H, Uemura T, Kobayashi M, Chung RT, Sato C. Management strategies using pharmacogenomics in patients with severe HCV-1b infection: a decision analysis. Hepatology. 2002 Jul; 36(1):177-85.
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  237. Lauer GM, Ouchi K, Chung RT, Nguyen TN, Day CL, Purkis DR, Reiser M, Kim AY, Lucas M, Klenerman P, Walker BD. Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. J Virol. 2002 Jun; 76(12):6104-13.
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  238. Dellon ES, Szczepiorkowski ZM, Dzik WH, Graeme-Cook F, Ades A, Bloomer JR, Cosimi AB, Chung RT. Treatment of recurrent allograft dysfunction with intravenous hematin after liver transplantation for erythropoietic protoporphyria. Transplantation. 2002 Mar 27; 73(6):911-5.
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  239. Lauer GM, Nguyen TN, Day CL, Robbins GK, Flynn T, McGowan K, Rosenberg ES, Lucas M, Klenerman P, Chung RT, Walker BD. Human immunodeficiency virus type 1-hepatitis C virus coinfection: intraindividual comparison of cellular immune responses against two persistent viruses. J Virol. 2002 Mar; 76(6):2817-26.
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  240. Ross AS, Graeme-Cook F, Cosimi AB, Chung RT. Combined liver and kidney transplantation in a patient with sickle cell disease. Transplantation. 2002 Feb 27; 73(4):605-8.
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  241. Sherman KE, Rouster SD, Chung RT, Rajicic N. Hepatitis C Virus prevalence among patients infected with Human Immunodeficiency Virus: a cross-sectional analysis of the US adult AIDS Clinical Trials Group. Clin Infect Dis. 2002 Mar 15; 34(6):831-7.
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  242. Rosenberg PM, Farrell JJ, Abraczinskas DR, Graeme-Cook FM, Dienstag JL, Chung RT. Rapidly progressive fibrosing cholestatic hepatitis--hepatitis C virus in HIV coinfection. Am J Gastroenterol. 2002 Feb; 97(2):478-83.
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  243. Baid S, Cosimi AB, Farrell ML, Schoenfeld DA, Feng S, Chung RT, Tolkoff-Rubin N, Pascual M. Posttransplant diabetes mellitus in liver transplant recipients: risk factors, temporal relationship with hepatitis C virus allograft hepatitis, and impact on mortality. Transplantation. 2001 Sep 27; 72(6):1066-72.
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  244. Chung RT, He W, Saquib A, Contreras AM, Xavier RJ, Chawla A, Wang TC, Schmidt EV. Hepatitis C virus replication is directly inhibited by IFN-alpha in a full-length binary expression system. Proc Natl Acad Sci U S A. 2001 Aug 14; 98(17):9847-52.
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  245. Chung RT, Feng S, Delmonico FL. Approach to the management of allograft recipients following the detection of hepatitis B virus in the prospective organ donor. Am J Transplant. 2001 Jul; 1(2):185-91.
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  246. Wong DK, Dudley DD, Dohrenwend PB, Lauer GM, Chung RT, Thomas DL, Walker BD. Detection of diverse hepatitis C virus (HCV)-specific cytotoxic T lymphocytes in peripheral blood of infected persons by screening for responses to all translated proteins of HCV. J Virol. 2001 Feb; 75(3):1229-35.
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  247. Chung RT, Kim AY, Polsky B. HIV/Hepatitis B and C co-infection: pathogenic interactions, natural history and therapy. Antivir Chem Chemother. 2001; 12 Suppl 1:73-91.
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  248. Lo SC, Levin L, Ribas J, Chung R, Wang RY, Wear D, Shih JW. Lack of serological evidence for Mycoplasma fermentans infection in army Gulf War veterans: a large scale case-control study. Epidemiol Infect. 2000 Dec; 125(3):609-16.
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  249. Abraczinskas DR, Chung RT. Allograft dysfunction and hyperbilirubinemia in a liver transplant recipient. Transpl Infect Dis. 2000 Dec; 2(4):186-93.
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  250. Farrell JJ, Cosimi AB, Chung RT. Idiopathic giant esophageal ulcers in a renal transplant patient responsive to steroid therapy. Transplantation. 2000 Jul 15; 70(1):230-2.
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  251. Lechner F, Wong DK, Dunbar PR, Chapman R, Chung RT, Dohrenwend P, Robbins G, Phillips R, Klenerman P, Walker BD. Analysis of successful immune responses in persons infected with hepatitis C virus. J Exp Med. 2000 May 1; 191(9):1499-512.
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  252. Abrahamian GA, Cosimi AB, Farrell ML, Schoenfeld DA, Chung RT, Pascual M. Prevalence of hepatitis C virus-associated mixed cryoglobulinemia after liver transplantation. Liver Transpl. 2000 Mar; 6(2):185-90.
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  253. Kim AY, Chung RT, Polsky B. Human immunodeficiency virus and hepatitis B and C coinfection: pathogenic interactions, natural history, and therapy. AIDS Clin Rev. 2000-2001; 263-306.
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  254. Baid S, Pascual M, Cosimi AB, Chung RT, Colvin RB, Tolkoff-Rubin N. Viruses and thrombotic microangiopathy. Transplantation. 1999 Sep 15; 68(5):710-1.
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  255. Chung RT, Monto A, Dienstag JL, Kaplan LM. Mutations in the NS5A region do not predict interferon-responsiveness in american patients infected with genotype 1b hepatitis C virus. J Med Virol. 1999 Aug; 58(4):353-8.
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  256. Chung RT, Kaplan LM. Heterogeneous nuclear ribonucleoprotein I (hnRNP-I/PTB) selectively binds the conserved 3' terminus of hepatitis C viral RNA. Biochem Biophys Res Commun. 1999 Jan 19; 254(2):351-62.
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  257. Baid S, Pascual M, Williams WW, Tolkoff-Rubin N, Johnson SM, Collins B, Chung RT, Delmonico FL, Cosimi AB, Colvin RB. Renal thrombotic microangiopathy associated with anticardiolipin antibodies in hepatitis C-positive renal allograft recipients. J Am Soc Nephrol. 1999 Jan; 10(1):146-53.
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  258. Chung WS, Cho C, Kim S, Wang Y, Lee S, Tarin T, Chung R, Housman L, Jamieson SW. Review of significant microvascular surgical breakthroughs involving the heart and lungs in rats. Microsurgery. 1999; 19(2):71-7.
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  259. Toth CM, Pascual M, Chung RT, Graeme-Cook F, Dienstag JL, Bhan AK, Cosimi AB. Hepatitis C virus-associated fibrosing cholestatic hepatitis after renal transplantation: response to interferon-alpha therapy. Transplantation. 1998 Nov 15; 66(9):1254-8.
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  260. Oldfield EC, Fessel WJ, Dunne MW, Dickinson G, Wallace MR, Byrne W, Chung R, Wagner KF, Paparello SF, Craig DB, Melcher G, Zajdowicz M, Williams RF, Kelly JW, Zelasky M, Heifets LB, Berman JD. Once weekly azithromycin therapy for prevention of Mycobacterium avium complex infection in patients with AIDS: a randomized, double-blind, placebo-controlled multicenter trial. Clin Infect Dis. 1998 Mar; 26(3):611-9.
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  261. Pascual M, Thadhani R, Chung RT, Williams WW, Meehan S, Tolkoff-Rubin N, Colvin R, Cosimi AB. Nephrotic syndrome after liver transplantation in a patient with hepatitis C virus-associated glomerulonephritis. Transplantation. 1997 Oct 15; 64(7):1073-6.
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  262. Kawamura T, Furusaka A, Koziel MJ, Chung RT, Wang TC, Schmidt EV, Liang TJ. Transgenic expression of hepatitis C virus structural proteins in the mouse. Hepatology. 1997 Apr; 25(4):1014-21.
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  263. Jaffe DL, Chung RT, Friedman LS. Management of portal hypertension and its complications. Med Clin North Am. 1996 Sep; 80(5):1021-34.
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  264. Obeid F, Saba A, Fath J, Guslits B, Chung R, Sorensen V, Buck J, Horst M. Increases in intra-abdominal pressure affect pulmonary compliance. Arch Surg. 1995 May; 130(5):544-7; discussion 547-8.
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  265. Brown AE, Lane JR, Wagner KF, Zhou S, Chung R, Ray KL, Blatt SP, Burke DS. Rates of p24 antigenemia and viral isolation in comparable white and black HIV-infected subjects. Military Medical Consortium for Applied Retroviral Research. AIDS. 1995 Apr; 9(4):325-8.
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  266. Chung RT, Jaffe DL, Friedman LS. Complications of chronic liver disease. Crit Care Clin. 1995 Apr; 11(2):431-63.
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  267. Chung RT. Just say "NO" to viral hepatitis? Hepatology. 1994 Mar; 19(3):790-2.
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  268. Mayers DL, Japour AJ, Arduino JM, Hammer SM, Reichman R, Wagner KF, Chung R, Lane J, Crumpacker CS, McLeod GX, et al. Dideoxynucleoside resistance emerges with prolonged zidovudine monotherapy. The RV43 Study Group. Antimicrob Agents Chemother. 1994 Feb; 38(2):307-14.
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  269. Schmaier AH, Dahl LD, Rozemuller AJ, Roos RA, Wagner SL, Chung R, Van Nostrand WE. Protease nexin-2/amyloid beta protein precursor. A tight-binding inhibitor of coagulation factor IXa. J Clin Invest. 1993 Nov; 92(5):2540-5.
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  270. Chung RT, Schapiro RH, Warshaw AL. Intraluminal pancreatic candidiasis presenting as recurrent pancreatitis. Gastroenterology. 1993 May; 104(5):1532-4.
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  271. Chung RT, Kaplan LM. Parenterally transmitted hepatitis: viruses, vaccines, and antiviral therapy. Compr Ther. 1993; 19(4):163-73.
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  272. Agnello V, Chung RT, Kaplan LM. A role for hepatitis C virus infection in type II cryoglobulinemia. N Engl J Med. 1992 Nov 19; 327(21):1490-5.
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  273. Chung R, Whaley J, Kley N, Anderson K, Louis D, Menon A, Hettlich C, Freiman R, Hedley-Whyte ET, Martuza R, et al. TP53 gene mutations and 17p deletions in human astrocytomas. Genes Chromosomes Cancer. 1991 Sep; 3(5):323-31.
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  274. Tramont EC, Chung R, Berman S, Keren D, Kapfer C, Formal SB. Safety and antigenicity of typhoid-Shigella sonnei vaccine (strain 5076-1C). J Infect Dis. 1984 Feb; 149(2):133-6.
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  275. Chung R, Lewis JW. Cost of treatment of bleeding esophageal varices. Arch Surg. 1983 Apr; 118(4):482-5.
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