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Jose Carlos Crispin Acuna, M.D.

TitleAssistant Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Rheumatology - Dana 517-C
330 Brookline Ave
Boston MA 02215
Phone617/667-2786
Fax617/667-2785

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Adalid-Peralta L, Fleury A, García-Ibarra TM, Hernández M, Parkhouse M, Crispín JC, Voltaire-Proaño J, Cárdenas G, Fragoso G, Sciutto E. Human neurocysticercosis: in vivo expansion of peripheral regulatory T cells and their recruitment in the central nervous system. J Parasitol. 2012 Feb; 98(1):142-8.
    View in: PubMed
  2. Apostolidis SA, Lieberman LA, Kis-Toth K, Crispín JC, Tsokos GC. The dysregulation of cytokine networks in systemic lupus erythematosus. J Interferon Cytokine Res. 2011 Oct; 31(10):769-79.
    View in: PubMed
  3. Crispín JC, Apostolidis SA, Finnell MI, Tsokos GC. Induction of PP2A Bß, a regulator of IL-2 deprivation-induced T-cell apoptosis, is deficient in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12443-8.
    View in: PubMed
  4. Sáenz B, Fleury A, Chavarría A, Hernández M, Crispin JC, Vargas-Rojas MI, Fragoso G, Sciutto E. Neurocysticercosis: local and systemic immune-inflammatory features related to severity. Med Microbiol Immunol. 2012 Feb; 201(1):73-80.
    View in: PubMed
  5. Crispín JC. Regulatory T cells as modulators of B cell antibody production. Clin Immunol. 2011 Sep; 140(3):216-7.
    View in: PubMed
  6. Apostolidis SA, Crispín JC, Tsokos GC. IL-17-producing T cells in lupus nephritis. Lupus. 2011 Feb; 20(2):120-4.
    View in: PubMed
  7. Ichinose K, Juang YT, Crispín JC, Kis-Toth K, Tsokos GC. Suppression of autoimmunity and organ pathology in lupus-prone mice upon inhibition of calcium/calmodulin-dependent protein kinase type IV. Arthritis Rheum. 2011 Feb; 63(2):523-9.
    View in: PubMed
  8. Gómez-Martín D, Díaz-Zamudio M, Vanoye G, Crispín JC, Alcocer-Varela J. Quantitative and functional profiles of CD4+ lymphocyte subsets in systemic lupus erythematosus patients with lymphopenia. Clin Exp Immunol. 2011 Apr; 164(1):17-25.
    View in: PubMed
  9. Crispín JC, Tsokos GC. Interleukin-17-producing T cells in lupus. Curr Opin Rheumatol. 2010 Sep; 22(5):499-503.
    View in: PubMed
  10. Crispín JC, Kyttaris VC, Terhorst C, Tsokos GC. T cells as therapeutic targets in SLE. Nat Rev Rheumatol. 2010 Jun; 6(6):317-25.
    View in: PubMed
  11. Crispín JC, Keenan BT, Finnell MD, Bermas BL, Schur P, Massarotti E, Karlson EW, Fitzgerald LM, Ergin S, Kyttaris VC, Tsokos GC, Costenbader KH. Expression of CD44 variant isoforms CD44v3 and CD44v6 is increased on T cells from patients with systemic lupus erythematosus and is correlated with disease activity. Arthritis Rheum. 2010 May; 62(5):1431-7.
    View in: PubMed
  12. Crispín JC, Tsokos GC. IL-17 in systemic lupus erythematosus. J Biomed Biotechnol. 2010; 2010:943254.
    View in: PubMed
  13. Crispín JC, Liossis SN, Kis-Toth K, Lieberman LA, Kyttaris VC, Juang YT, Tsokos GC. Pathogenesis of human systemic lupus erythematosus: recent advances. Trends Mol Med. 2010 Feb; 16(2):47-57.
    View in: PubMed
  14. Crispín JC, Tsokos GC. Human TCR-alpha beta+ CD4- CD8- T cells can derive from CD8+ T cells and display an inflammatory effector phenotype. J Immunol. 2009 Oct 1; 183(7):4675-81.
    View in: PubMed
  15. Nalbandian A, Crispín JC, Tsokos GC. Interleukin-17 and systemic lupus erythematosus: current concepts. Clin Exp Immunol. 2009 Aug; 157(2):209-15.
    View in: PubMed
  16. Valdés-Ferrer SI, Crispín JC, Belaunzarán PF, Cantú-Brito CG, Sierra-Madero J, Alcocer-Varela J. Acetylcholine-esterase inhibitor pyridostigmine decreases T cell overactivation in patients infected by HIV. AIDS Res Hum Retroviruses. 2009 Aug; 25(8):749-55.
    View in: PubMed
  17. Chen J, Crispín JC, Dalle Lucca J, Tsokos GC. A novel inhibitor of the alternative pathway of complement attenuates intestinal ischemia/reperfusion-induced injury. J Surg Res. 2011 May 15; 167(2):e131-6.
    View in: PubMed
  18. Chen J, Crispín JC, Tedder TF, Dalle Lucca J, Tsokos GC. B cells contribute to ischemia/reperfusion-mediated tissue injury. J Autoimmun. 2009 May-Jun; 32(3-4):195-200.
    View in: PubMed
  19. Gómez-Martín D, Díaz-Zamudio M, Crispín JC, Alcocer-Varela J. Interleukin 2 and systemic lupus erythematosus: beyond the transcriptional regulatory net abnormalities. Autoimmun Rev. 2009 Sep; 9(1):34-9.
    View in: PubMed
  20. Crispín JC, Oukka M, Bayliss G, Cohen RA, Van Beek CA, Stillman IE, Kyttaris VC, Juang YT, Tsokos GC. Expanded double negative T cells in patients with systemic lupus erythematosus produce IL-17 and infiltrate the kidneys. J Immunol. 2008 Dec 15; 181(12):8761-6.
    View in: PubMed
  21. Edgerton C, Crispín JC, Moratz CM, Bettelli E, Oukka M, Simovic M, Zacharia A, Egan R, Chen J, Dalle Lucca JJ, Juang YT, Tsokos GC. IL-17 producing CD4+ T cells mediate accelerated ischemia/reperfusion-induced injury in autoimmunity-prone mice. Clin Immunol. 2009 Mar; 130(3):313-21.
    View in: PubMed
  22. Crispín JC, Tsokos GC. Transcriptional regulation of IL-2 in health and autoimmunity. Autoimmun Rev. 2009 Jan; 8(3):190-5.
    View in: PubMed
  23. Cohen RA, Bayliss G, Crispin JC, Kane-Wanger GF, Van Beek CA, Kyttaris VC, Avalos I, Yu CY, Tsokos GC, Stillman IE. T cells and in situ cryoglobulin deposition in the pathogenesis of lupus nephritis. Clin Immunol. 2008 Jul; 128(1):1-7.
    View in: PubMed
  24. Vargas-Rojas MI, Crispín JC, Richaud-Patin Y, Alcocer-Varela J. Quantitative and qualitative normal regulatory T cells are not capable of inducing suppression in SLE patients due to T-cell resistance. Lupus. 2008 Apr; 17(4):289-94.
    View in: PubMed
  25. Crispín JC, Kyttaris VC, Juang YT, Tsokos GC. How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype. Trends Immunol. 2008 Mar; 29(3):110-5.
    View in: PubMed
  26. Crispín JC, Tsokos GC. Novel molecular targets in the treatment of systemic lupus erythematosus. Autoimmun Rev. 2008 Jan; 7(3):256-61.
    View in: PubMed
  27. Crispín JC, Kyttaris V, Juang YT, Tsokos GC. Systemic lupus erythematosus: new molecular targets. Ann Rheum Dis. 2007 Nov; 66 Suppl 3:iii65-9.
    View in: PubMed
  28. Alberú J, Morales-Buenrostro LE, de Leo C, Vargas-Rojas MI, Marino-Vázquez LA, Crispín JC. A non-allogeneic stimulus triggers the production of de novo HLA antibodies in healthy adults. Transpl Immunol. 2007 Nov; 18(2):166-71.
    View in: PubMed
  29. Crispin JC, Alcocer-Varela J. The role myeloid dendritic cells play in the pathogenesis of systemic lupus erythematosus. Autoimmun Rev. 2007 Aug; 6(7):450-6.
    View in: PubMed
  30. Hernández-Molina G, Crispín JC, Kimura-Hayama E, Rull-Gabayet M. Chronic destructive elbow arthropathy associated with hydroxyapatite crystals in a patient with systemic lupus erythematosus. J Clin Rheumatol. 2006 Aug; 12(4):194-5.
    View in: PubMed
  31. Hernández-Molina G, Reyes E, Crispín JC. ANCA associated glomerulonephritis in a patient with mixed connective tissue disease. Ann Rheum Dis. 2006 Mar; 65(3):410-1.
    View in: PubMed
  32. Martínez-Baños D, Crispín JC, Lazo-Langner A, Sánchez-Guerrero J. Moderate and severe neutropenia in patients with systemic lupus erythematosus. Rheumatology (Oxford). 2006 Aug; 45(8):994-8.
    View in: PubMed
  33. Crispín JC, Martínez-Baños D, Alcocer-Varela J. Adult-onset Still disease as the cause of fever of unknown origin. Medicine (Baltimore). 2005 Nov; 84(6):331-7.
    View in: PubMed
  34. Crispín JC, Díaz-Jouanen E. Systemic lupus erythematosus induced by therapy with interferon-beta in a patient with multiple sclerosis. Lupus. 2005; 14(6):495-6.
    View in: PubMed
  35. Díaz-Alderete A, Crispin JC, Vargas-Rojas MI, Alcocer-Varela J. IL-10 production in B cells is confined to CD154+ cells in patients with systemic lupus erythematosus. J Autoimmun. 2004 Dec; 23(4):379-83.
    View in: PubMed
  36. Crispin JC, Fallena M, Kraus A. Identity loss due to chronic fingertip ischemia. J Rheumatol. 2004 Jun; 31(6):1222-4.
    View in: PubMed
  37. Soto-Vega E, García-Muñoz R, Richaud-Patin Y, Zúñiga-Ramos J, Crispín JC, Díaz-Jouanen E, Flores-Suárez LF, Llorente L, Granados J. Class I and class II MHC polymorphisms in Mexican patients with Behçet's disease. Immunol Lett. 2004 May 15; 93(2-3):211-5.
    View in: PubMed
  38. Crispin JC, Vargas MI, Alcocer-Varela J. Immunoregulatory T cells in autoimmunity. Autoimmun Rev. 2004 Feb; 3(2):45-51.
    View in: PubMed
  39. Crispin JC, Martínez A, Alcocer-Varela J. Quantification of regulatory T cells in patients with systemic lupus erythematosus. J Autoimmun. 2003 Nov; 21(3):273-6.
    View in: PubMed
  40. Crispin JC, Alcocer-Varela J. Rheumatologic manifestations of diabetes mellitus. Am J Med. 2003 Jun 15; 114(9):753-7.
    View in: PubMed
  41. Crispin JC, Alcocer-Varela J, de Pablo P, Martínez A, Richaud-Patin Y, Alarcón-Segovia D. Immunoregulatory defects in patients with systemic lupus erythematosus in clinical remission. Lupus. 2003; 12(5):386-93.
    View in: PubMed
  42. Crispin JC, Martínez A, de Pablo P, Velasquillo C, Alcocer-Varela J. Participation of the CD69 antigen in the T-cell activation process of patients with systemic lupus erythematosus. Scand J Immunol. 1998 Aug; 48(2):196-200.
    View in: PubMed
  43. Crispin JC, Alcocer-Varela J. Interleukin-2 and systemic lupus erythematosus--fifteen years later. Lupus. 1998; 7(4):214-22.
    View in: PubMed
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