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Basil Pawlyk, M.SC.

TitleAssociate in Ophthalmology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology
AddressMassachusetts Eye & Ear Infrm
Ophthalmology
243 Charles St
Boston MA 02114
Phone617/573-3600

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wiggs JL, Pawlyk B, Connolly E, Adamian M, Miller JW, Pasquale LR, Haddadin RI, Grosskreutz CL, Rhee DJ, Li T. Disruption of the blood-aqueous barrier and lens abnormalities in mice lacking Lysyl Oxidase-like 1 (LOXL1). Invest Ophthalmol Vis Sci. 2014 Jan 14.
    View in: PubMed
  2. Thanos A, Morizane Y, Murakami Y, Giani A, Mantopoulos D, Kayama M, Roh MI, Michaud N, Pawlyk B, Sandberg M, Young LH, Miller JW, Vavvas DG. Evidence for baseline retinal pigment epithelium pathology in the Trp1-Cre mouse. Am J Pathol. 2012 May; 180(5):1917-27.
    View in: PubMed
  3. Pawlyk BS, Bulgakov OV, Liu X, Xu X, Adamian M, Sun X, Khani SC, Berson EL, Sandberg MA, Li T. Replacement gene therapy with a human RPGRIP1 sequence slows photoreceptor degeneration in a murine model of Leber congenital amaurosis. Hum Gene Ther. 2010 Aug; 21(8):993-1004.
    View in: PubMed
  4. Yang J, Liu X, Zhao Y, Adamian M, Pawlyk B, Sun X, McMillan DR, Liberman MC, Li T. Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss. PLoS Genet. 2010 May; 6(5):e1000955.
    View in: PubMed
  5. Liu X, Pawlyk BS, Adamian M, Olshevskaya EV, Dizhoor AM, Makino CL, Li T. Increased light exposure alleviates one form of photoreceptor degeneration marked by elevated calcium in the dark. PLoS One. 2009; 4(12):e8438.
    View in: PubMed
  6. Sun X, Pawlyk B, Xu X, Liu X, Bulgakov OV, Adamian M, Sandberg MA, Khani SC, Tan MH, Smith AJ, Ali RR, Li T. Gene therapy with a promoter targeting both rods and cones rescues retinal degeneration caused by AIPL1 mutations. Gene Ther. 2010 Jan; 17(1):117-31.
    View in: PubMed
  7. Tan MH, Smith AJ, Pawlyk B, Xu X, Liu X, Bainbridge JB, Basche M, McIntosh J, Tran HV, Nathwani A, Li T, Ali RR. Gene therapy for retinitis pigmentosa and Leber congenital amaurosis caused by defects in AIPL1: effective rescue of mouse models of partial and complete Aipl1 deficiency using AAV2/2 and AAV2/8 vectors. Hum Mol Genet. 2009 Jun 15; 18(12):2099-114.
    View in: PubMed
  8. Khani SC, Pawlyk BS, Bulgakov OV, Kasperek E, Young JE, Adamian M, Sun X, Smith AJ, Ali RR, Li T. AAV-mediated expression targeting of rod and cone photoreceptors with a human rhodopsin kinase promoter. Invest Ophthalmol Vis Sci. 2007 Sep; 48(9):3954-61.
    View in: PubMed
  9. Storch KF, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T, Weitz CJ. Intrinsic circadian clock of the mammalian retina: importance for retinal processing of visual information. Cell. 2007 Aug 24; 130(4):730-41.
    View in: PubMed
  10. Denny CA, Alroy J, Pawlyk BS, Sandberg MA, d'Azzo A, Seyfried TN. Neurochemical, morphological, and neurophysiological abnormalities in retinas of Sandhoff and GM1 gangliosidosis mice. J Neurochem. 2007 Jun; 101(5):1294-302.
    View in: PubMed
  11. Yang J, Pawlyk B, Wen XH, Adamian M, Soloviev M, Michaud N, Zhao Y, Sandberg MA, Makino CL, Li T. Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals. Hum Mol Genet. 2007 May 1; 16(9):1017-29.
    View in: PubMed
  12. Liu X, Bulgakov OV, Darrow KN, Pawlyk B, Adamian M, Liberman MC, Li T. Usherin is required for maintenance of retinal photoreceptors and normal development of cochlear hair cells. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4413-8.
    View in: PubMed
  13. Storch KF, Paz C, Signorovitch J, Raviola E, Pawlyk B, Li T, Weitz CJ. Physiological importance of a circadian clock outside the suprachiasmatic nucleus. Cold Spring Harb Symp Quant Biol. 2007; 72:307-18.
    View in: PubMed
  14. Adamian M, Pawlyk BS, Hong DH, Berson EL. Rod and cone opsin mislocalization in an autopsy eye from a carrier of X-linked retinitis pigmentosa with a Gly436Asp mutation in the RPGR gene. Am J Ophthalmol. 2006 Sep; 142(3):515-8.
    View in: PubMed
  15. Makino CL, Wen XH, Michaud N, Peshenko IV, Pawlyk B, Brush RS, Soloviev M, Liu X, Woodruff ML, Calvert PD, Savchenko AB, Anderson RE, Fain GL, Li T, Sandberg MA, Dizhoor AM. Effects of low AIPL1 expression on phototransduction in rods. Invest Ophthalmol Vis Sci. 2006 May; 47(5):2185-94.
    View in: PubMed
  16. Liu X, Zhao Y, Pawlyk B, Damaser M, Li T. Failure of elastic fiber homeostasis leads to pelvic floor disorders. Am J Pathol. 2006 Feb; 168(2):519-28.
    View in: PubMed
  17. Landis MW, Pawlyk BS, Li T, Sicinski P, Hinds PW. Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis. Cancer Cell. 2006 Jan; 9(1):13-22.
    View in: PubMed
  18. Pawlyk BS, Smith AJ, Buch PK, Adamian M, Hong DH, Sandberg MA, Ali RR, Li T. Gene replacement therapy rescues photoreceptor degeneration in a murine model of Leber congenital amaurosis lacking RPGRIP. Invest Ophthalmol Vis Sci. 2005 Sep; 46(9):3039-45.
    View in: PubMed
  19. Yang J, Gao J, Adamian M, Wen XH, Pawlyk B, Zhang L, Sanderson MJ, Zuo J, Makino CL, Li T. The ciliary rootlet maintains long-term stability of sensory cilia. Mol Cell Biol. 2005 May; 25(10):4129-37.
    View in: PubMed
  20. Hong DH, Pawlyk BS, Adamian M, Sandberg MA, Li T. A single, abbreviated RPGR-ORF15 variant reconstitutes RPGR function in vivo. Invest Ophthalmol Vis Sci. 2005 Feb; 46(2):435-41.
    View in: PubMed
  21. Carthon BC, Neumann CA, Das M, Pawlyk B, Li T, Geng Y, Sicinski P. Genetic replacement of cyclin D1 function in mouse development by cyclin D2. Mol Cell Biol. 2005 Feb; 25(3):1081-8.
    View in: PubMed
  22. Liu X, Bulgakov OV, Wen XH, Woodruff ML, Pawlyk B, Yang J, Fain GL, Sandberg MA, Makino CL, Li T. AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase. Proc Natl Acad Sci U S A. 2004 Sep 21; 101(38):13903-8.
    View in: PubMed
  23. Liu X, Zhao Y, Gao J, Pawlyk B, Starcher B, Spencer JA, Yanagisawa H, Zuo J, Li T. Elastic fiber homeostasis requires lysyl oxidase-like 1 protein. Nat Genet. 2004 Feb; 36(2):178-82.
    View in: PubMed
  24. Hong DH, Pawlyk BS, Adamian M, Li T. Dominant, gain-of-function mutant produced by truncation of RPGR. Invest Ophthalmol Vis Sci. 2004 Jan; 45(1):36-41.
    View in: PubMed
  25. Marneros AG, Keene DR, Hansen U, Fukai N, Moulton K, Goletz PL, Moiseyev G, Pawlyk BS, Halfter W, Dong S, Shibata M, Li T, Crouch RK, Bruckner P, Olsen BR. Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J. 2004 Jan 14; 23(1):89-99.
    View in: PubMed
  26. Hong DH, Pawlyk B, Sokolov M, Strissel KJ, Yang J, Tulloch B, Wright AF, Arshavsky VY, Li T. RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia. Invest Ophthalmol Vis Sci. 2003 Jun; 44(6):2413-21.
    View in: PubMed
  27. Zhao Y, Hong DH, Pawlyk B, Yue G, Adamian M, Grynberg M, Godzik A, Li T. The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis. Proc Natl Acad Sci U S A. 2003 Apr 1; 100(7):3965-70.
    View in: PubMed
  28. Pawlyk BS, Li T, Scimeca MS, Sandberg MA, Berson EL. Absence of photoreceptor rescue with D-cis-diltiazem in the rd mouse. Invest Ophthalmol Vis Sci. 2002 Jun; 43(6):1912-5.
    View in: PubMed
  29. Hagstrom SA, Adamian M, Scimeca M, Pawlyk BS, Yue G, Li T. A role for the Tubby-like protein 1 in rhodopsin transport. Invest Ophthalmol Vis Sci. 2001 Aug; 42(9):1955-62.
    View in: PubMed
  30. Lu C, Peng YW, Shang J, Pawlyk BS, Yu F, Li T. The mammalian retinal degeneration B2 gene is not required for photoreceptor function and survival. Neuroscience. 2001; 107(1):35-41.
    View in: PubMed
  31. Ciulla TA, Pawlyk BS, Harris A, Oberoi A, Miller JW, Sandberg MA. Endothelin-1-mediated retinal artery vasospasm and the rabbit electroretinogram. J Ocul Pharmacol Ther. 2000 Aug; 16(4):393-8.
    View in: PubMed
  32. Hong DH, Pawlyk BS, Shang J, Sandberg MA, Berson EL, Li T. A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3). Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3649-54.
    View in: PubMed
  33. Sandberg MA, Pawlyk BS, Berson EL. Acuity recovery and cone pigment regeneration after a bleach in patients with retinitis pigmentosa and rhodopsin mutations. Invest Ophthalmol Vis Sci. 1999 Sep; 40(10):2457-61.
    View in: PubMed
  34. Li T, Sandberg MA, Pawlyk BS, Rosner B, Hayes KC, Dryja TP, Berson EL. Effect of vitamin A supplementation on rhodopsin mutants threonine-17 --> methionine and proline-347 --> serine in transgenic mice and in cell cultures. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11933-8.
    View in: PubMed
  35. Sandberg MA, Pawlyk BS, Dan J, Arnaud B, Dryja TP, Berson EL. Rod and cone function in the Nougaret form of stationary night blindness. Arch Ophthalmol. 1998 Jul; 116(7):867-72.
    View in: PubMed
  36. Tang M, Pawlyk BS, Kosaras B, Berson EL, Sidman RL. ERG abnormalities in relation to histopathologic findings in vitiligo mutant mice. Exp Eye Res. 1997 Aug; 65(2):215-22.
    View in: PubMed
  37. Sandberg MA, Pawlyk BS, Berson EL. Isolation of focal rod electroretinograms from the dark-adapted human eye. Invest Ophthalmol Vis Sci. 1996 Apr; 37(5):930-4.
    View in: PubMed
  38. Olsson JE, Gordon JW, Pawlyk BS, Roof D, Hayes A, Molday RS, Mukai S, Cowley GS, Berson EL, Dryja TP. Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron. 1992 Nov; 9(5):815-30.
    View in: PubMed
  39. Pawlyk BS, Sandberg MA, Berson EL. Effects of IBMX on the rod ERG of the isolated perfused cat eye: antagonism with light, calcium or L-cis-diltiazem. Vision Res. 1991; 31(7-8):1093-7.
    View in: PubMed
  40. Sandberg MA, Pawlyk BS, Crane WG, Berson EL. Diurnal rhythm in the electroretinogram of the Royal College of Surgeons (RCS) pigmented rat. Exp Eye Res. 1988 Jun; 46(6):929-36.
    View in: PubMed
  41. Sandberg MA, Pawlyk BS, Crane WG, Schmidt SY, Berson EL. Effects of IBMX on the ERG of the isolated perfused cat eye. Vision Res. 1987; 27(9):1421-30.
    View in: PubMed
  42. Sandberg MA, Pawlyk BS, Berson EL. Electroretinogram (ERG) sensitivity and phagosome frequency in the normal pigmented rat. Exp Eye Res. 1986 Nov; 43(5):781-9.
    View in: PubMed
  43. Sandberg MA, Pawlyk BS, Berson EL. Full-field electroretinograms in miniature poodles with progressive rod-cone degeneration. Invest Ophthalmol Vis Sci. 1986 Jul; 27(7):1179-84.
    View in: PubMed
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