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Akiko Mammoto, PH.D.

TitleInstructor in Surgery
InstitutionChildren's Hospital Boston
DepartmentSurgery
AddressChildrens Hospital
Enders 10
300 Longwood Ave
Boston MA 02115
Phone617/355-7496
Fax617/566-6467

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mammoto T, Jiang E, Jiang A, Mammoto A. Extracellular Matrix Structure and Tissue Stiffness Control Postnatal Lung Development through the Lipoprotein Receptor-Related Protein 5/Tie2 Signaling System. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):1009-18.
    View in: PubMed
  2. Mammoto T, Mammoto A, Ingber DE. Mechanobiology and developmental control. Annu Rev Cell Dev Biol. 2013 Oct 6; 29:27-61.
    View in: PubMed
  3. Mammoto T, Jiang E, Jiang A, Lu Y, Juan AM, Chen J, Mammoto A. Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering tie2 expression. PLoS One. 2013; 8(9):e73407.
    View in: PubMed
  4. Bischof AG, Yüksel D, Mammoto T, Mammoto A, Krause S, Ingber DE. Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan. Integr Biol (Camb). 2013 Aug 22; 5(8):1045-56.
    View in: PubMed
  5. Mammoto T, Jiang A, Jiang E, Panigrahy D, Kieran MW, Mammoto A. Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression. Am J Pathol. 2013 Oct; 183(4):1293-305.
    View in: PubMed
  6. Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D'Amore PA, Puder M, Zeldin DC, Kieran MW. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13528-33.
    View in: PubMed
  7. Coma S, Allard-Ratick M, Akino T, van Meeteren LA, Mammoto A, Klagsbrun M. GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2. Angiogenesis. 2013 Oct; 16(4):939-52.
    View in: PubMed
  8. Levesque BM, Kalish LA, Winston AB, Parad RB, Hernandez-Diaz S, Phillips M, Zolit A, Morey J, Gupta M, Mammoto A, Ingber DE, Van Marter LJ. Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity. Neonatology. 2013; 104(1):56-64.
    View in: PubMed
  9. Mammoto T, Jiang A, Jiang E, Mammoto A. Platelet rich plasma extract promotes angiogenesis through the angiopoietin1-Tie2 pathway. Microvasc Res. 2013 Sep; 89:15-24.
    View in: PubMed
  10. Mammoto A, Mammoto T, Kanapathipillai M, Wing Yung C, Jiang E, Jiang A, Lofgren K, Gee EP, Ingber DE. Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics. Nat Commun. 2013 Apr 23; 4:1759.
    View in: PubMed
  11. Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, Coma S, Italiano JE, Mammoto A, Bielenberg DR, Klagsbrun M. Netrin-1 Promotes Glioblastoma Cell Invasiveness and Angiogenesis by Multiple Pathways Including Activation of RhoA, Cathepsin B, and cAMP-response Element-binding Protein. J Biol Chem. 2013 Jan 25; 288(4):2210-22.
    View in: PubMed
  12. Sero JE, German AE, Mammoto A, Ingber DE. Paxillin controls directional cell motility in response to physical cues. Cell Adh Migr. 2012 Nov 1; 6(6):502-8.
    View in: PubMed
  13. Mammoto T, Chen J, Jiang E, Jiang A, Smith LE, Ingber DE, Mammoto A. LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PLoS One. 2012; 7(7):e41596.
    View in: PubMed
  14. Mammoto A, Mammoto T, Ingber DE. Mechanosensitive mechanisms in transcriptional regulation. J Cell Sci. 2012 Jul 1; 125(Pt 13):3061-73.
    View in: PubMed
  15. Kanapathipillai M, Mammoto A, Mammoto T, Kang JH, Jiang E, Ghosh K, Korin N, Gibbs A, Mannix R, Ingber DE. Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix. Nano Lett. 2012 Jun 13; 12(6):3213-7.
    View in: PubMed
  16. Kang JH, Krause S, Tobin H, Mammoto A, Kanapathipillai M, Ingber DE. A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells. Lab Chip. 2012 Jun 21; 12(12):2175-81.
    View in: PubMed
  17. Panigrahy D, Edin ML, Lee CR, Huang S, Bielenberg DR, Butterfield CE, Barnés CM, Mammoto A, Mammoto T, Luria A, Benny O, Chaponis DM, Dudley AC, Greene ER, Vergilio JA, Pietramaggiori G, Scherer-Pietramaggiori SS, Short SM, Seth M, Lih FB, Tomer KB, Yang J, Schwendener RA, Hammock BD, Falck JR, Manthati VL, Ingber DE, Kaipainen A, D'Amore PA, Kieran MW, Zeldin DC. Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice. J Clin Invest. 2012 Jan 3; 122(1):178-91.
    View in: PubMed
  18. Sero JE, Thodeti CK, Mammoto A, Bakal C, Thomas S, Ingber DE. Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning. PLoS One. 2011; 6(12):e28303.
    View in: PubMed
  19. Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, Sapieha P, Hua J, Hatton CJ, Juan AM, Aderman CM, Willett KL, Guerin KI, Mammoto A, Campbell M, Smith LE. Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation. 2011 Oct 25; 124(17):1871-81.
    View in: PubMed
  20. Mammoto T, Mammoto A, Torisawa YS, Tat T, Gibbs A, Derda R, Mannix R, de Bruijn M, Yung CW, Huh D, Ingber DE. Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Dev Cell. 2011 Oct 18; 21(4):758-69.
    View in: PubMed
  21. Derda R, Tang SK, Laromaine A, Mosadegh B, Hong E, Mwangi M, Mammoto A, Ingber DE, Whitesides GM. Multizone paper platform for 3D cell cultures. PLoS One. 2011; 6(5):e18940.
    View in: PubMed
  22. Xu Y, Bismar TA, Su J, Xu B, Kristiansen G, Varga Z, Teng L, Ingber DE, Mammoto A, Kumar R, Alaoui-Jamali MA. Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med. 2010 Oct 25; 207(11):2421-37.
    View in: PubMed
  23. Matthews BD, Thodeti CK, Tytell JD, Mammoto A, Overby DR, Ingber DE. Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integr Biol (Camb). 2010 Sep; 2(9):435-42.
    View in: PubMed
  24. Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE. Reconstituting organ-level lung functions on a chip. Science. 2010 Jun 25; 328(5986):1662-8.
    View in: PubMed
  25. Derda R, Laromaine A, Mammoto A, Tang SK, Mammoto T, Ingber DE, Whitesides GM. Paper-supported 3D cell culture for tissue-based bioassays. Proc Natl Acad Sci U S A. 2009 Nov 3; 106(44):18457-62.
    View in: PubMed
  26. Mammoto A, Ingber DE. Cytoskeletal control of growth and cell fate switching. Curr Opin Cell Biol. 2009 Dec; 21(6):864-70.
    View in: PubMed
  27. Czakó B, Kürti L, Mammoto A, Ingber DE, Corey EJ. Discovery of potent and practical antiangiogenic agents inspired by cortistatin A. J Am Chem Soc. 2009 Jul 1; 131(25):9014-9.
    View in: PubMed
  28. Thodeti CK, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha AL, Ingber DE. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res. 2009 May 8; 104(9):1123-30.
    View in: PubMed
  29. Mammoto A, Connor KM, Mammoto T, Yung CW, Huh D, Aderman CM, Mostoslavsky G, Smith LE, Ingber DE. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature. 2009 Feb 26; 457(7233):1103-8.
    View in: PubMed
  30. Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, Ingber DE. Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11305-10.
    View in: PubMed
  31. Shimizu A, Mammoto A, Italiano JE, Pravda E, Dudley AC, Ingber DE, Klagsbrun M. ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. J Biol Chem. 2008 Oct 3; 283(40):27230-8.
    View in: PubMed
  32. Mammoto A, Mammoto T, Ingber DE. Rho signaling and mechanical control of vascular development. Curr Opin Hematol. 2008 May; 15(3):228-34.
    View in: PubMed
  33. Mammoto A, Sero JE, Mammoto T, Ingber DE. Methods for studying mechanical control of angiogenesis by the cytoskeleton and extracellular matrix. Methods Enzymol. 2008; 443:227-59.
    View in: PubMed
  34. Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP. Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem. 2007 Aug 17; 282(33):23910-8.
    View in: PubMed
  35. Chen Z, Naveiras O, Balduini A, Mammoto A, Conti MA, Adelstein RS, Ingber D, Daley GQ, Shivdasani RA. The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway. Blood. 2007 Jul 1; 110(1):171-9.
    View in: PubMed
  36. Mammoto A, Huang S, Ingber DE. Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J Cell Sci. 2007 Feb 1; 120(Pt 3):456-67.
    View in: PubMed
  37. Mammoto A, Huang S, Moore K, Oh P, Ingber DE. Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition. J Biol Chem. 2004 Jun 18; 279(25):26323-30.
    View in: PubMed
  38. Nanba D, Mammoto A, Hashimoto K, Higashiyama S. Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF. J Cell Biol. 2003 Nov 10; 163(3):489-502.
    View in: PubMed
  39. Mammoto T, Mukai M, Mammoto A, Yamanaka Y, Hayashi Y, Mashimo T, Kishi Y, Nakamura H. Intravenous anesthetic, propofol inhibits invasion of cancer cells. Cancer Lett. 2002 Oct 28; 184(2):165-70.
    View in: PubMed
  40. Mammoto T, Higashiyama S, Mukai M, Mammoto A, Ayaki M, Mashimo T, Hayashi Y, Kishi Y, Nakamura H, Akedo H. Infiltration anesthetic lidocaine inhibits cancer cell invasion by modulating ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF). J Cell Physiol. 2002 Sep; 192(3):351-8.
    View in: PubMed
  41. Fujiwara T, Mammoto A, Kim Y, Takai Y. Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2. Biochem Biophys Res Commun. 2000 May 19; 271(3):626-9.
    View in: PubMed
  42. Mammoto A, Sasaki T, Kim Y, Takai Y. Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking. J Biol Chem. 2000 May 5; 275(18):13167-70.
    View in: PubMed
  43. Mammoto A, Takahashi K, Sasaki T, Takai Y. Stimulation of Rho GDI release by ERM proteins. Methods Enzymol. 2000; 325:91-101.
    View in: PubMed
  44. Mammoto A, Ohtsuka T, Hotta I, Sasaki T, Takai Y. Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recycling. J Biol Chem. 1999 Sep 3; 274(36):25517-24.
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  45. Nakano K, Takaishi K, Kodama A, Mammoto A, Shiozaki H, Monden M, Takai Y. Distinct actions and cooperative roles of ROCK and mDia in Rho small G protein-induced reorganization of the actin cytoskeleton in Madin-Darby canine kidney cells. Mol Biol Cell. 1999 Aug; 10(8):2481-91.
    View in: PubMed
  46. Takahashi K, Sasaki T, Mammoto A, Hotta I, Takaishi K, Imamura H, Nakano K, Kodama A, Takai Y. Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl. Oncogene. 1998 Jun 25; 16(25):3279-84.
    View in: PubMed
  47. Mammoto A, Sasaki T, Asakura T, Hotta I, Imamura H, Takahashi K, Matsuura Y, Shirao T, Takai Y. Interactions of drebrin and gephyrin with profilin. Biochem Biophys Res Commun. 1998 Feb 4; 243(1):86-9.
    View in: PubMed
  48. Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S, Takai Y. Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein. J Biol Chem. 1997 Sep 12; 272(37):23371-5.
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  49. Mammoto A, Masumoto N, Tahara M, Yoneda M, Nishizaki T, Tasaka K, Miyake A. Involvement of a sperm protein sensitive to sulfhydryl-depleting reagents in mouse sperm-egg fusion. J Exp Zool. 1997 Jun 15; 278(3):178-88.
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  50. Masumoto N, Sasaki T, Tahara M, Mammoto A, Ikebuchi Y, Tasaka K, Tokunaga M, Takai Y, Miyake A. Involvement of Rabphilin-3A in cortical granule exocytosis in mouse eggs. J Cell Biol. 1996 Dec; 135(6 Pt 2):1741-7.
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  51. Mammoto A, Masumoto N, Tahara M, Ikebuchi Y, Ohmichi M, Tasaka K, Miyake A. Reactive oxygen species block sperm-egg fusion via oxidation of sperm sulfhydryl proteins in mice. Biol Reprod. 1996 Nov; 55(5):1063-8.
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  52. Tahara M, Tasaka K, Masumoto N, Mammoto A, Ikebuchi Y, Miyake A. Dynamics of cortical granule exocytosis at fertilization in living mouse eggs. Am J Physiol. 1996 May; 270(5 Pt 1):C1354-61.
    View in: PubMed
  53. Yamaguchi M, Sakata M, Ogura K, Adachi K, Mammoto A, Miyake A. Inhibition of mouse placental lactogen-II release from placental cells by interleukin-1 after mid-pregnancy. J Endocrinol. 1995 Dec; 147(3):423-9.
    View in: PubMed
  54. Yamaguchi M, Mammoto A, Taga T, Kishimoto T, Miyake A. Regulation of mouse soluble interleukin-6 receptor secretion by decidua. Biochem Biophys Res Commun. 1995 Jun 26; 211(3):1077-82.
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  55. Mizuki J, Masumoto N, Tahara M, Fukami K, Mammoto A, Tasaka K, Miyake A. Scanning electron microscope assessment of exocytotic changes in purified gonadotropes. J Endocrinol. 1995 Feb; 144(2):193-200.
    View in: PubMed
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