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Last Name
Institution

Michael Chorev, Ph.D.

TitleAssociate Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Lab for Translational Research
75 Francis St
Boston MA 02115
Phone617/667-0901
Fax617/621-6148

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Chen L, Aktas BH, Wang Y, He X, Sahoo R, Zhang N, Denoyelle S, Kabha E, Yang H, Freedman RY, Supko JG, Chorev M, Wagner G, Halperin JA. Tumor suppression by small molecule inhibitors of translation initiation. Oncotarget. 2012 Aug; 3(8):869-81.
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  2. Wu L, Su S, Liu F, Xu T, Wang X, Huang Y, Sun X, Ge X, Chen T, Liu H, Wang C, Chorev M, Xu T, Qin X. Removal of the Tag from His-tagged ILYd4, a Human CD59 Inhibitor, Significantly Improves its Physical Properties and its Activity. Curr Pharm Des. 2012; 18(27):4187-96.
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  3. Scrima M, Grimaldi M, Di Marino S, Testa C, Rovero P, Papini AM, Chorev M, D'Ursi AM. Solvent independent conformational propensities of [1,2,3]triazolyl-bridged parathyroid hormone-related peptide-derived cyclo-nonapeptide analogues. Biopolymers. 2012; 98(6):535-45.
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  4. Denoyelle S, Chen T, Chen L, Wang Y, Klosi E, Halperin JA, Aktas BH, Chorev M. In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents. Bioorg Med Chem Lett. 2012 Jan 1; 22(1):402-9.
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  5. Rizzolo F, Testa C, Lambardi D, Chorev M, Chelli M, Rovero P, Papini AM. Conventional and microwave-assisted SPPS approach: a comparative synthesis of PTHrP(1-34)NH(2). J Pept Sci. 2011 Oct; 17(10):708-14.
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  6. Chen T, Ozel D, Qiao Y, Harbinski F, Chen L, Denoyelle S, He X, Zvereva N, Supko JG, Chorev M, Halperin JA, Aktas BH. Chemical genetics identify eIF2a kinase heme-regulated inhibitor as an anticancer target. Nat Chem Biol. 2011 Sep; 7(9):610-6.
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  7. Hoeffer CA, Cowansage KK, Arnold EC, Banko JL, Moerke NJ, Rodriguez R, Schmidt EK, Klosi E, Chorev M, Lloyd RE, Pierre P, Wagner G, LeDoux JE, Klann E. Inhibition of the interactions between eukaryotic initiation factors 4E and 4G impairs long-term associative memory consolidation but not reconsolidation. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3383-8.
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  8. Hu W, Ge X, You T, Xu T, Zhang J, Wu G, Peng Z, Chorev M, Aktas BH, Halperin JA, Brown JR, Qin X. Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis. Cancer Res. 2011 Mar 15; 71(6):2298-307.
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  9. Le Chevalier Isaad A, Papini AM, Chorev M, Rovero P. Side chain-to-side chain cyclization by click reaction. J Pept Sci. 2009 Jul; 15(7):451-4.
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  10. Carganico S, Rovero P, Halperin JA, Papini AM, Chorev M. Building blocks for the synthesis of post-translationally modified glycated peptides and proteins. J Pept Sci. 2009 Feb; 15(2):67-71.
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  11. Cantel S, Halperin JA, Chorev M, Scrima M, D'Ursi AM, Levy JJ, DiMarchi RD, Le Chevalier A, Rovero P, Papini AM. Side chain-to-side chain cyclization by intramolecular click reaction--building blocks, solid phase synthesis and conformational characterization. Adv Exp Med Biol. 2009; 611:175-6.
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  12. Cantel S, Kavishwar A, Schlimme M, Khatri A, Halperin JA, Chorev M. Glycated-CD59 antigen: exploration of synthetic approaches. Adv Exp Med Biol. 2009; 611:317-8.
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  13. Caporale A, Fiori N, Schievano E, Wittelsberger A, Mammi S, Chorev M, Peggion E. Structure-function relationship study of parathyroid hormone (1-11) analogues containing D-AA. Adv Exp Med Biol. 2009; 611:113-4.
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  14. Cantel S, Isaad Ale C, Scrima M, Levy JJ, DiMarchi RD, Rovero P, Halperin JA, D'Ursi AM, Papini AM, Chorev M. Synthesis and conformational analysis of a cyclic peptide obtained via i to i+4 intramolecular side-chain to side-chain azide-alkyne 1,3-dipolar cycloaddition. J Org Chem. 2008 Aug 1; 73(15):5663-74.
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  15. Fiori N, Caporale A, Schievano E, Mammi S, Geyer A, Tremmel P, Wittelsberger A, Woznica I, Chorev M, Peggion E. Structure-function relationship studies of PTH(1-11) analogues containing sterically hindered dipeptide mimetics. J Pept Sci. 2007 Aug; 13(8):504-12.
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  16. Hyberts SG, Heffron GJ, Tarragona NG, Solanky K, Edmonds KA, Luithardt H, Fejzo J, Chorev M, Aktas H, Colson K, Falchuk KH, Halperin JA, Wagner G. Ultrahigh-resolution (1)H-(13)C HSQC spectra of metabolite mixtures using nonlinear sampling and forward maximum entropy reconstruction. J Am Chem Soc. 2007 Apr 25; 129(16):5108-16.
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  17. Moerke NJ, Aktas H, Chen H, Cantel S, Reibarkh MY, Fahmy A, Gross JD, Degterev A, Yuan J, Chorev M, Halperin JA, Wagner G. Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G. Cell. 2007 Jan 26; 128(2):257-67.
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  18. Gabet Y, Müller R, Levy J, Dimarchi R, Chorev M, Bab I, Kohavi D. Parathyroid hormone 1-34 enhances titanium implant anchorage in low-density trabecular bone: a correlative micro-computed tomographic and biomechanical analysis. Bone. 2006 Aug; 39(2):276-82.
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  19. Wittelsberger A, Corich M, Thomas BE, Lee BK, Barazza A, Czodrowski P, Mierke DF, Chorev M, Rosenblatt M. The mid-region of parathyroid hormone (1-34) serves as a functional docking domain in receptor activation. Biochemistry. 2006 Feb 21; 45(7):2027-34.
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  20. Scian M, Marin M, Bellanda M, Tou L, Alexander JM, Rosenblatt M, Chorev M, Peggion E, Mammi S. Backbone dynamics of human parathyroid hormone (1-34): flexibility of the central region under different environmental conditions. Biopolymers. 2006; 84(2):147-60.
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  21. Natarajan A, Guo Y, Arthanari H, Wagner G, Halperin JA, Chorev M. Synthetic studies toward aryl-(4-aryl-4H-[1,2,4]triazole-3-yl)-amine from 1,3-diarylthiourea as urea mimetics. J Org Chem. 2005 Aug 5; 70(16):6362-8.
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  22. Gabet Y, Kohavi D, Müller R, Chorev M, Bab I. Intermittently administered parathyroid hormone 1-34 reverses bone loss and structural impairment in orchiectomized adult rats. Osteoporos Int. 2005 Nov; 16(11):1436-43.
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  23. Barazza A, Wittelsberger A, Fiori N, Schievano E, Mammi S, Toniolo C, Alexander JM, Rosenblatt M, Peggion E, Chorev M. Bioactive N-terminal undecapeptides derived from parathyroid hormone: the role of alpha-helicity. J Pept Res. 2005 Jan; 65(1):23-35.
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  24. Chorev M. The partial retro-inverso modification: a road traveled together. Biopolymers. 2005; 80(2-3):67-84.
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  25. von Stechow D, Zurakowski D, Pettit AR, Müller R, Gronowicz G, Chorev M, Otu H, Libermann T, Alexander JM. Differential transcriptional effects of PTH and estrogen during anabolic bone formation. J Cell Biochem. 2004 Oct 15; 93(3):476-90.
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  26. Natarajan A, Guo Y, Harbinski F, Fan YH, Chen H, Luus L, Diercks J, Aktas H, Chorev M, Halperin JA. Novel arylsulfoanilide-oxindole hybrid as an anticancer agent that inhibits translation initiation. J Med Chem. 2004 Oct 7; 47(21):4979-82.
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  27. Qin X, Goldfine A, Krumrei N, Grubissich L, Acosta J, Chorev M, Hays AP, Halperin JA. Glycation inactivation of the complement regulatory protein CD59: a possible role in the pathogenesis of the vascular complications of human diabetes. Diabetes. 2004 Oct; 53(10):2653-61.
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  28. Gabet Y, Müller R, Regev E, Sela J, Shteyer A, Salisbury K, Chorev M, Bab I. Osteogenic growth peptide modulates fracture callus structural and mechanical properties. Bone. 2004 Jul; 35(1):65-73.
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  29. Schievano E, Mammi S, Carretta E, Fiori N, Corich M, Bisello A, Rosenblatt M, Chorev M, Peggion E. Conformational and biological characterization of human parathyroid hormone hPTH(1-34) analogues containing beta-amino acid residues in positions 17-19. Biopolymers. 2003 Dec; 70(4):534-47.
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  30. von Stechow D, Fish S, Yahalom D, Bab I, Chorev M, Müller R, Alexander JM. Does simvastatin stimulate bone formation in vivo? BMC Musculoskelet Disord. 2003 Apr 28; 4:8.
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  31. Sawyer TK, Chorev M. Peptide revolution: genomics, proteomics and therapeutics. Biotechniques. 2003 Mar; 34(3):594-6, 598-9.
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  32. Peggion E, Mammi S, Schievano E, Schiebler L, Corich M, Rosenblatt M, Chorev M. Structure-function relationship studies of bovine parathyroid hormone [bPTH(1-34)] analogues containing alpha-amino-iso-butyric acid (Aib) residues. Biopolymers. 2003 Mar; 68(3):437-57.
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  33. Sterling J, Herzig Y, Goren T, Finkelstein N, Lerner D, Goldenberg W, Miskolczi I, Molnar S, Rantal F, Tamas T, Toth G, Zagyva A, Zekany A, Finberg J, Lavian G, Gross A, Friedman R, Razin M, Huang W, Krais B, Chorev M, Youdim MB, Weinstock M. Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease. J Med Chem. 2002 Nov 21; 45(24):5260-79.
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  34. Han Y, Giragossian C, Mierke DF, Chorev M. Ni-to-Ni+ 3-ethylene-bridged partially modified retro-inverso tetrapeptide beta-turn mimetic: design, synthesis, and structural characterization. J Org Chem. 2002 Jul 26; 67(15):5085-97.
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  35. Bisello A, Chorev M, Rosenblatt M, Monticelli L, Mierke DF, Ferrari SL. Selective ligand-induced stabilization of active and desensitized parathyroid hormone type 1 receptor conformations. J Biol Chem. 2002 Oct 11; 277(41):38524-30.
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  36. Yahalom D, Wittelsberger A, Mierke DF, Rosenblatt M, Alexander JM, Chorev M. Identification of the principal binding site for RGD-containing ligands in the alpha(V)beta(3) integrin: a photoaffinity cross-linking study. Biochemistry. 2002 Jul 2; 41(26):8321-31.
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  37. Peggion E, Mammi S, Schievano E, Silvestri L, Schiebler L, Bisello A, Rosenblatt M, Chorev M. Structure-function studies of analogues of parathyroid hormone (PTH)-1-34 containing beta-amino acid residues in positions 11-13. Biochemistry. 2002 Jun 25; 41(25):8162-75.
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  38. Piserchio A, Han Y, Chorev M, Mierke DF. Structural characterization of a cyclic dipeptidomimetic: the effect of ring size on a 1,2,5-trisubstituted-3-oxo-1,4-diazepine system. Biopolymers. 2002 Jun; 64(1):16-25.
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  39. Han Y, Mierke DF, Chorev M. Homologs of 1,2,5-hexahydro-3-one-1H-1,4-diazepine (DAP) as novel dipeptidomimetics and molecular scaffolds: efficient preparation of synthons. Biopolymers. 2002 Jun; 64(1):1-15.
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  40. Chen YC, Muhlrad A, Shteyer A, Vidson M, Bab I, Chorev M. Bioactive pseudopeptidic analogues and cyclostereoisomers of osteogenic growth peptide C-terminal pentapeptide, OGP(10-14). J Med Chem. 2002 Apr 11; 45(8):1624-32.
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  41. Chorev M. Parathyroid hormone 1 receptor: insights into structure and function. Receptors Channels. 2002; 8(3-4):219-42.
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  42. Bab I, Chorev M. Osteogenic growth peptide: from concept to drug design. Biopolymers. 2002; 66(1):33-48.
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  43. Scheibler L, Mierke DF, Bitan G, Rosenblatt M, Chorev M. Identification of a contact domain between echistatin and the integrin alpha(v)beta(3) by photoaffinity cross-linking. Biochemistry. 2001 Dec 18; 40(50):15117-26.
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  44. Alexander JM, Bab I, Fish S, Müller R, Uchiyama T, Gronowicz G, Nahounou M, Zhao Q, White DW, Chorev M, Gazit D, Rosenblatt M. Human parathyroid hormone 1-34 reverses bone loss in ovariectomized mice. J Bone Miner Res. 2001 Sep; 16(9):1665-73.
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  45. Cohen RN, Brzostek S, Kim B, Chorev M, Wondisford FE, Hollenberg AN. The specificity of interactions between nuclear hormone receptors and corepressors is mediated by distinct amino acid sequences within the interacting domains. Mol Endocrinol. 2001 Jul; 15(7):1049-61.
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  46. Schievano E, Bisello A, Chorev M, Bisol A, Mammi S, Peggion E. Aib-rich peptides containing lactam-bridged side chains as models of the 3(10)-helix. J Am Chem Soc. 2001 Mar 28; 123(12):2743-51.
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  47. Gabarin N, Gavish H, Muhlrad A, Chen YC, Namdar-Attar M, Nissenson RA, Chorev M, Bab I. Mitogenic G(i) protein-MAP kinase signaling cascade in MC3T3-E1 osteogenic cells: activation by C-terminal pentapeptide of osteogenic growth peptide [OGP(10-14)] and attenuation of activation by cAMP. J Cell Biochem. 2001; 81(4):594-603.
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  48. Schievano E, Mammi S, Silvestri L, Behar V, Rosenblatt M, Chorev M, Peggion E. Conformational studies of parathyroid hormone (PTH)/PTH-related protein (PTHrp) chimeric peptides. Biopolymers. 2000 Nov; 54(6):429-47.
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  49. Bitan G, Scheibler L, Mierke DF, Rosenblatt M, Chorev M. Ligand-integrin alpha v beta 3 interaction determined by photoaffinity cross-linking: a challenge to the prevailing model. Biochemistry. 2000 Sep 12; 39(36):11014-23.
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  50. Chen YC, Bab I, Mansur N, Muhlrad A, Shteyer A, Namdar-Attar M, Gavish H, Vidson M, Chorev M. Structure-bioactivity of C-terminal pentapeptide of osteogenic growth peptide [OGP(10-14)]. J Pept Res. 2000 Sep; 56(3):147-56.
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  51. Greenberg Z, Bisello A, Mierke DF, Rosenblatt M, Chorev M. Mapping the bimolecular interface of the parathyroid hormone (PTH)-PTH1 receptor complex: spatial proximity between Lys(27) (of the hormone principal binding domain) and leu(261) (of the first extracellular loop) of the human PTH1 receptor. Biochemistry. 2000 Jul 18; 39(28):8142-52.
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  52. Piserchio A, Bisello A, Rosenblatt M, Chorev M, Mierke DF. Characterization of parathyroid hormone/receptor interactions: structure of the first extracellular loop. Biochemistry. 2000 Jul 18; 39(28):8153-60.
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  53. Han Y, Bisello A, Nakamoto C, Rosenblatt M, Chorev M. 3-(3'-fluorenyl-9'-oxo)-L-alanine: a novel photoreactive conformationally constrained amino acid. J Pept Res. 2000 Mar; 55(3):230-9.
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  54. Bitan G, Scheibler L, Teng H, Rosenblatt M, Chorev M. Design and evaluation of benzophenone-containing conformationally constrained ligands as tools for photoaffinity scanning of the integrin alphaVbeta3-ligand bimolecular interaction. J Pept Res. 2000 Mar; 55(3):181-94.
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  55. Ferrari SL, Traianedes K, Thorne M, Lafage-Proust MH, Genever P, Cecchini MG, Behar V, Bisello A, Chorev M, Rosenblatt M, Suva LJ. A role for N-cadherin in the development of the differentiated osteoblastic phenotype. J Bone Miner Res. 2000 Feb; 15(2):198-208.
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  56. Behar V, Bisello A, Bitan G, Rosenblatt M, Chorev M. Photoaffinity cross-linking identifies differences in the interactions of an agonist and an antagonist with the parathyroid hormone/parathyroid hormone-related protein receptor. J Biol Chem. 2000 Jan 7; 275(1):9-17.
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  57. Bab I, Gavish H, Namdar-Attar M, Muhlrad A, Greenberg Z, Chen Y, Mansur N, Shteyer A, Chorev M. Isolation of mitogenically active C-terminal truncated pentapeptide of osteogenic growth peptide from human plasma and culture medium of murine osteoblastic cells. J Pept Res. 1999 Nov; 54(5):408-14.
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  58. Peggion E, Mammi S, Schievano E, Behar V, Rosenblatt M, Chorev M. Conformational studies of parathyroid hormone (PTH)/PTH-related protein (PTHrP) point-mutated hybrids. Biopolymers. 1999 Oct 15; 50(5):525-35.
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  59. Ferrari SL, Behar V, Chorev M, Rosenblatt M, Bisello A. Endocytosis of ligand-human parathyroid hormone receptor 1 complexes is protein kinase C-dependent and involves beta-arrestin2. Real-time monitoring by fluorescence microscopy. J Biol Chem. 1999 Oct 15; 274(42):29968-75.
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  60. Luo Y, Chen X, Han R, Chorev M, Dewolf WC, O'Donnell MA. Mutated ras p21 as a target for cancer therapy in mouse transitional cell carcinoma. J Urol. 1999 Oct; 162(4):1519-26.
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  61. Behar V, Bisello A, Rosenblatt M, Chorev M. Direct identification of two contact sites for parathyroid hormone (PTH) in the novel PTH-2 receptor using photoaffinity cross-linking. Endocrinology. 1999 Sep; 140(9):4251-61.
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  62. Bisello A, Behar V, Greenberg Z, Suva LJ, Rosenblatt M, Chorev M. Development of a photoreactive parathyroid hormone antagonist to probe antagonist-receptor bimolecular interaction. J Pept Res. 1999 Aug; 54(2):120-8.
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  63. Schievano E, Mammi S, Bisello A, Rosenblatt M, Chorev M, Peggion E. Conformational studies of a bicyclic, lactam-constrained parathyroid hormone-related protein-derived agonist. J Pept Sci. 1999 Jul; 5(7):330-7.
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  64. Bab I, Smith E, Gavish H, Attar-Namdar M, Chorev M, Chen YC, Muhlrad A, Birnbaum MJ, Stein G, Frenkel B. Biosynthesis of osteogenic growth peptide via alternative translational initiation at AUG85 of histone H4 mRNA. J Biol Chem. 1999 May 14; 274(20):14474-81.
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  65. Han Y, Chorev M. A Novel, One-Pot Reductive Alkylation of Amines by S-Ethyl Thioesters Mediated by Triethylsilane and Sodium Triacetoxyborohydride in the Presence of Palladium on Carbon. J Org Chem. 1999 Mar 19; 64(6):1972-1978.
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  66. Bitan G, Scheibler L, Greenberg Z, Rosenblatt M, Chorev M. Mapping the integrin alpha V beta 3-ligand interface by photoaffinity cross-linking. Biochemistry. 1999 Mar 16; 38(11):3414-20.
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  67. Greenberg Z, Stoch SA, Traianedes K, Teng H, Rosenblatt M, Chorev M. Covalent immobilization of recombinant human alphavbeta3 integrin on a solid support with retention of functionality. Anal Biochem. 1999 Jan 1; 266(1):153-64.
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  68. Adams AE, Bisello A, Chorev M, Rosenblatt M, Suva LJ. Arginine 186 in the extracellular N-terminal region of the human parathyroid hormone 1 receptor is essential for contact with position 13 of the hormone. Mol Endocrinol. 1998 Nov; 12(11):1673-83.
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  69. Pellegrini M, Bisello A, Rosenblatt M, Chorev M, Mierke DF. Binding domain of human parathyroid hormone receptor: from conformation to function. Biochemistry. 1998 Sep 15; 37(37):12737-43.
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  70. Maretto S, Schievano E, Mammi S, Bisello A, Nakamoto C, Rosenblatt M, Chorev M, Peggion E. Conformational studies of a potent Leu11,D-Trp12-containing lactam-bridged parathyroid hormone-related protein-derived antagonist. J Pept Res. 1998 Sep; 52(3):241-8.
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  71. Bisello A, Adams AE, Mierke DF, Pellegrini M, Rosenblatt M, Suva LJ, Chorev M. Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies. J Biol Chem. 1998 Aug 28; 273(35):22498-505.
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  72. Zor T, Andorn R, Sofer I, Chorev M, Selinger Z. GTP analogue hydrolysis by the Gs protein: implication for the role of catalytic glutamine in the GTPase reaction. FEBS Lett. 1998 Aug 21; 433(3):326-30.
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  73. Pellegrini M, Royo M, Rosenblatt M, Chorev M, Mierke DF. Addressing the tertiary structure of human parathyroid hormone-(1-34). J Biol Chem. 1998 Apr 24; 273(17):10420-7.
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  74. Fukayama S, Royo M, Sugita M, Imrich A, Chorev M, Suva LJ, Rosenblatt M, Tashjian AH. New insights into interactions between the human PTH/PTHrP receptor and agonist/antagonist binding. Am J Physiol. 1998 Feb; 274(2 Pt 1):E297-303.
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  75. Gavish H, Bab I, Tartakovsky A, Chorev M, Mansur N, Greenberg Z, Namdar-Attar M, Muhlrad A. Human alpha 2-macroglobulin is an osteogenic growth peptide-binding protein. Biochemistry. 1997 Dec 2; 36(48):14883-8.
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  76. Rosen HN, Lim M, Garber J, Moreau S, Bhargava HN, Pallotta J, Spark R, Greenspan S, Rosenblatt M, Chorev M. The effect of PTH antagonist BIM-44002 on serum calcium and PTH levels in hypercalcemic hyperparathyroid patients. Calcif Tissue Int. 1997 Dec; 61(6):455-9.
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  77. Suva LJ, Flannery MS, Caulfield MP, Findlay DM, Jüppner H, Goldring SR, Rosenblatt M, Chorev M. Design, synthesis and utility of novel benzophenone-containing calcitonin analogs for photoaffinity labeling the calcitonin receptor. J Pharmacol Exp Ther. 1997 Nov; 283(2):876-84.
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  78. Pellegrini M, Bisello A, Rosenblatt M, Chorev M, Mierke DF. Conformational studies of RS-66271, an analog of parathyroid hormone-related protein with pronounced bone anabolic activity. J Med Chem. 1997 Sep 12; 40(19):3025-31.
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  79. Mierke DF, Maretto S, Schievano E, DeLuca D, Bisello A, Mammi S, Rosenblatt M, Peggion E, Chorev M. Conformational studies of mono- and bicyclic parathyroid hormone-related protein-derived agonists. Biochemistry. 1997 Aug 26; 36(34):10372-83.
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  80. Greenberg Z, Gavish H, Muhlrad A, Chorev M, Shteyer A, Attar-Namdar M, Tartakovsky A, Bab I. Isolation of osteogenic growth peptide from osteoblastic MC3T3 E1 cell cultures and demonstration of osteogenic growth peptide binding proteins. J Cell Biochem. 1997 Jun 1; 65(3):359-67.
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  81. Pellegrini M, Royo M, Chorev M, Mierke DF. Conformational consequences of i, i + 3 cystine linkages: nucleation for alpha-helicity? J Pept Res. 1997 May; 49(5):404-14.
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  82. Zhou AT, Bessalle R, Bisello A, Nakamoto C, Rosenblatt M, Suva LJ, Chorev M. Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):3644-9.
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  83. Bisello A, Nakamoto C, Rosenblatt M, Chorev M. Mono- and bicyclic analogs of parathyroid hormone-related protein. 1. Synthesis and biological studies. Biochemistry. 1997 Mar 18; 36(11):3293-9.
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  84. Maretto S, Mammi S, Bissacco E, Peggion E, Bisello A, Rosenblatt M, Chorev M, Mierke DF. Mono- and bicyclic analogs of parathyroid hormone-related protein. 2. Conformational analysis of antagonists by CD, NMR, and distance geometry calculations. Biochemistry. 1997 Mar 18; 36(11):3300-7.
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  85. Weitz IS, Pellegrini M, Mierke DF, Chorev M. Synthesis of a Trisubstituted 1,4-Diazepin-3-one-Based Dipeptidomimetic as a Novel Molecular Scaffold. J Org Chem. 1997 Apr 18; 62(8):2527-2534.
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  86. Gurevitch O, Slavin S, Muhlrad A, Shteyer A, Gazit D, Chorev M, Vidson M, Namdar-Attar M, Berger E, Bleiberg I, Bab I. Osteogenic growth peptide increases blood and bone marrow cellularity and enhances engraftment of bone marrow transplants in mice. Blood. 1996 Dec 15; 88(12):4719-24.
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  87. Bisello A, Greenberg Z, Behar V, Rosenblatt M, Suva LJ, Chorev M. Role of glycosylation in expression and function of the human parathyroid hormone/parathyroid hormone-related protein receptor. Biochemistry. 1996 Dec 10; 35(49):15890-5.
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  88. Gillo B, Chorna I, Cohen H, Cook B, Manistersky I, Chorev M, Arnon A, Pollock JA, Selinger Z, Minke B. Coexpression of Drosophila TRP and TRP-like proteins in Xenopus oocytes reconstitutes capacitative Ca2+ entry. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14146-51.
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  89. Behar V, Nakamoto C, Greenberg Z, Bisello A, Suva LJ, Rosenblatt M, Chorev M. Histidine at position 5 is the specificity "switch" between two parathyroid hormone receptor subtypes. Endocrinology. 1996 Oct; 137(10):4217-24.
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  90. Dresner-Pollak R, Yang QM, Behar V, Nakamoto C, Chorev M, Rosenblatt M. Evaluation in vivo of a potent parathyroid hormone antagonist: [Nle8,18,D-Trp12,Tyr34]bPTH(7-34)NH2. J Bone Miner Res. 1996 Aug; 11(8):1061-5.
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  91. Behar V, Pines M, Nakamoto C, Greenberg Z, Bisello A, Stueckle SM, Bessalle R, Usdin TB, Chorev M, Rosenblatt M, Suva LJ. The human PTH2 receptor: binding and signal transduction properties of the stably expressed recombinant receptor. Endocrinology. 1996 Jul; 137(7):2748-57.
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  92. Pines M, Fukayama S, Costas K, Meurer E, Goldsmith PK, Xu X, Muallem S, Behar V, Chorev M, Rosenblatt M, Tashjian AH, Suva LJ. Inositol 1-,4-,5-trisphosphate-dependent Ca2+ signaling by the recombinant human PTH/PTHrP receptor stably expressed in a human kidney cell line. Bone. 1996 Apr; 18(4):381-9.
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  93. Pellegrini M, Royo M, Chorev M, Mierke DF. Conformational characterization of a peptide mimetic of the third cytoplasmic loop of the G-protein coupled parathyroid hormone/parathyroid hormone related protein receptor. Biopolymers. 1996; 40(6):653-66.
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  94. Arad G, Bar-Meir R, Almog N, Chorev M, Kotler M. Avian sarcoma leukemia virus protease linked to the adjacent Gag polyprotein is enzymatically active. Virology. 1995 Dec 20; 214(2):439-44.
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  95. Chorev M, Gurrath M, Behar V, Mammi S, Tonello A, Peggion E. Conformation and interactions of bombolitin I analogues with SDS micelles and phospholipid vesicles: CD, fluorescence, two-dimensional NMR and computer simulations. Biopolymers. 1995 Oct; 36(4):473-84.
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  96. Chorev M, Behar V, Yang Q, Rosenblatt M, Mammi S, Maretto S, Pellegrini M, Peggion E. Conformation of parathyroid hormone antagonists by CD, NMR, and molecular dynamics simulations. Biopolymers. 1995 Oct; 36(4):485-95.
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  97. Chorev M, Goodman M. Recent developments in retro peptides and proteins--an ongoing topochemical exploration. Trends Biotechnol. 1995 Oct; 13(10):438-45.
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  98. Schetz JA, Mayr CA, Taylor JE, Rosenblatt M, Chorev M, Davis TP. Distribution and pharmacokinetics of a potent peptide antagonist of parathyroid hormone and parathyroid hormone-related protein in the rat. J Pharmacol Exp Ther. 1995 Sep; 274(3):1456-62.
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  99. Nakamoto C, Behar V, Chin KR, Adams AE, Suva LJ, Rosenblatt M, Chorev M. Probing the bimolecular interactions of parathyroid hormone with the human parathyroid hormone/parathyroid hormone-related protein receptor. 1. Design, synthesis and characterization of photoreactive benzophenone-containing analogs of parathyroid hormone. Biochemistry. 1995 Aug 22; 34(33):10546-52.
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  100. Adams AE, Pines M, Nakamoto C, Behar V, Yang QM, Bessalle R, Chorev M, Rosenblatt M, Levine MA, Suva LJ. Probing the bimolecular interactions of parathyroid hormone and the human parathyroid hormone/parathyroid hormone-related protein receptor. 2. Cloning, characterization, and photoaffinity labeling of the recombinant human receptor. Biochemistry. 1995 Aug 22; 34(33):10553-9.
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  101. Greenberg Z, Chorev M, Muhlrad A, Shteyer A, Namdar-Attar M, Casap N, Tartakovsky A, Vidson M, Bab I. Structural and functional characterization of osteogenic growth peptide from human serum: identity with rat and mouse homologs. J Clin Endocrinol Metab. 1995 Aug; 80(8):2330-5.
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  102. Arad G, Chorev M, Shtorch A, Goldblum A, Kotler M. Point mutation in avian sarcoma leukaemia virus protease which increases its activity but impairs infectious virus production. J Gen Virol. 1995 Aug; 76 ( Pt 8):1917-25.
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  103. Stavropoulos G, Karagiannis K, Anagnostides S, Ministrouski I, Selinger Z, Chorev M. Synthesis of potent agonists of substance P by replacement of Met11 with Glu(OBzl) and N-terminal glutamine with Glp of the C-terminal hexapeptide and heptapeptide of substance P. Int J Pept Protein Res. 1995 Jun; 45(6):508-13.
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  104. Zor T, Halifa I, Kleinhaus S, Chorev M, Selinger Z. m-Acetylanilido-GTP, a novel photoaffinity label for GTP-binding proteins: synthesis and application. Biochem J. 1995 Feb 15; 306 ( Pt 1):253-8.
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  105. Chorev M, Dresner-Pollak R, Eshel Y, Rosenblatt M. Approach to discovering novel therapeutic agents for osteoporosis based on integrin receptor blockade. Biopolymers. 1995; 37(6):367-75.
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  106. Chorev M, Suva LJ, Nakamoto C, Yang QM, Rashti-Behar V, Adams AE, Chin KR, Stueckle SM, Rosenblatt M. Approaches to studying the biomolecular interaction between the parathyroid hormone/parathyroid hormone-related protein receptor and its ligands. Miner Electrolyte Metab. 1995; 21(1-3):133-9.
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  107. Pines M, Adams AE, Stueckle S, Bessalle R, Rashti-Behar V, Chorev M, Rosenblatt M, Suva LJ. Generation and characterization of human kidney cell lines stably expressing recombinant human PTH/PTHrP receptor: lack of interaction with a C-terminal human PTH peptide. Endocrinology. 1994 Oct; 135(4):1713-6.
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  108. Weinstock M, Razin M, Chorev M, Enz A. Pharmacological evaluation of phenyl-carbamates as CNS-selective acetylcholinesterase inhibitors. J Neural Transm Suppl. 1994; 43:219-25.
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  109. Chorev M, Epand RF, Rosenblatt M, Caulfield MP, Epand RM. Circular dichroism (CD) studies of antagonists derived from parathyroid hormone-related protein. Int J Pept Protein Res. 1993 Oct; 42(4):342-5.
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  110. Greenberg Z, Chorev M, Muhlrad A, Shteyer A, Namdar M, Mansur N, Bab I. Mitogenic action of osteogenic growth peptide (OGP): role of amino and carboxy-terminal regions and charge. Biochim Biophys Acta. 1993 Sep 13; 1178(3):273-80.
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  111. Tallon M, Ron D, Halle D, Amodeo P, Saviano G, Temussi PA, Selinger Z, Naider F, Chorev M. Synthesis, biological activity, and conformational analysis of [pGlu6,N-MePhe8,Aib9] substance P (6-11): a selective agonist for the NK-3 receptor. Biopolymers. 1993 Jun; 33(6):915-26.
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  112. Eliakim R, Karmeli F, Chorev M, Okon E, Rachmilewitz D. Effect of drugs on colonic eicosanoid accumulation in active ulcerative colitis. Scand J Gastroenterol. 1992 Nov; 27(11):968-72.
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  113. Doza YN, Minke B, Chorev M, Selinger Z. Characterization of fly rhodopsin kinase. Eur J Biochem. 1992 Nov 1; 209(3):1035-40.
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  114. Chorev M, Caulfield MP, Roubini E, McKee RL, Gibbons SW, Leu CT, Levy JJ, Rosenblatt M. A novel, mild, specific and indirect maleimido-based radioiodolabeling method. Radiolabeling of analogs derived from parathyroid hormone (PTH) and PTH-related protein (PTHrP). Int J Pept Protein Res. 1992 Nov; 40(5):445-55.
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  115. Ron D, Gilon C, Hanani M, Vromen A, Selinger Z, Chorev M. N-methylated analogs of Ac[Nle28,31]CCK(26-33): synthesis, activity, and receptor selectivity. J Med Chem. 1992 Jul 24; 35(15):2806-11.
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  116. Bab I, Gazit D, Chorev M, Muhlrad A, Shteyer A, Greenberg Z, Namdar M, Kahn A. Histone H4-related osteogenic growth peptide (OGP): a novel circulating stimulator of osteoblastic activity. EMBO J. 1992 May; 11(5):1867-73.
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  117. Roubini E, Duong LT, Gibbons SW, Leu CT, Caulfield MP, Chorev M, Rosenblatt M. Synthesis of fully active biotinylated analogues of parathyroid hormone and parathyroid hormone-related protein as tools for the characterization of parathyroid hormone receptors. Biochemistry. 1992 Apr 28; 31(16):4026-33.
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  118. Weksler-Zangen S, Chorev M, Weinstock M. Contrasting influences of central and peripheral opioids on cardiac baroreflex sensitivity in rabbits. J Cardiovasc Pharmacol. 1992; 20(5):688-93.
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  119. Elmalem E, Chorev M, Weinstock M. Antagonism of morphine-induced respiratory depression by novel anticholinesterase agents. Neuropharmacology. 1991 Oct; 30(10):1059-64.
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  120. Roubini E, Laufer R, Gilon C, Selinger Z, Roques BP, Chorev M. Pseudopeptide analogues of substance P and leucine enkephalinamide containing the psi (CH2O) modification: synthesis and biological activity. J Med Chem. 1991 Aug; 34(8):2430-8.
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  121. Chorev M, Roubini E, McKee RL, Gibbons SW, Goldman ME, Caulfield MP, Rosenblatt M. Cyclic parathyroid hormone related protein antagonists: lysine 13 to aspartic acid 17 [i to (i + 4)] side chain to side chain lactamization. Biochemistry. 1991 Jun 18; 30(24):5968-74.
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  122. Gilon C, Halle D, Chorev M, Selinger Z, Byk G. Backbone cyclization: A new method for conferring conformational constraint on peptides. Biopolymers. 1991 May; 31(6):745-50.
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  123. Chorev M, Roubini E, Gilon C, Selinger Z. Toward nonpeptidal substance P mimetic analogues: design, synthesis, and biological activity. Biopolymers. 1991 May; 31(6):725-33.
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  124. Stavropoulos G, Karagiannis K, Cordopatis P, Halle D, Gilon C, Bar-Akiva G, Selinger Z, Chorev M. Synthesis and biological activity of substance P C-terminal hexapeptide and heptapeptide analogues. Int J Pept Protein Res. 1991 Mar; 37(3):180-4.
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  125. Rayan A, Fliess A, Kotler M, Chorev M, Goldblum A. Theoretical models of aspartic proteases: active site properties, dimer stability and interactions with model inhibitors. Adv Exp Med Biol. 1991; 306:555-8.
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  126. Chorev M, Roubini E, McKee RL, Gibbons SW, Reagan JE, Goldman ME, Caulfield MP, Rosenblatt M. Biological activity of parathyroid hormone antagonists substituted at position 13. Peptides. 1991 Jan-Feb; 12(1):57-62.
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  127. Chorev M, Roubini E, Goldman ME, McKee RL, Gibbons SW, Reagan JE, Caulfield MP, Rosenblatt M. Effects of hydrophobic substitutions at position 18 on the potency of parathyroid hormone antagonists. Int J Pept Protein Res. 1990 Nov; 36(5):465-70.
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  128. Papir-Kricheli D, Gilon C, Chorev M, Selinger Z, Devor M. Neurochemical mediators of the behavioural effects of receptor-selective substance P agonists administered intrathecally in the rat. Neuropharmacology. 1990 Nov; 29(11):1055-65.
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  129. Hanai H, Brennan DP, Cheng L, Goldman ME, Chorev M, Levine MA, Sacktor B, Liang CT. Downregulation of parathyroid hormone receptors in renal membranes from aged rats. Am J Physiol. 1990 Sep; 259(3 Pt 2):F444-50.
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  130. Wormser U, Laufer R, Chorev M, Gilon C, Selinger Z. Proteolytic resistance and biological activity of N-methylated analogs of [pGlu6] substance P6-11. Neuropeptides. 1990 May; 16(1):41-9.
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  131. Chorev M, Goldman ME, McKee RL, Roubini E, Levy JJ, Gay CT, Reagan JE, Fisher JE, Caporale LH, Golub EE, et al. Modifications of position 12 in parathyroid hormone and parathyroid hormone related protein: toward the design of highly potent antagonists. Biochemistry. 1990 Feb 13; 29(6):1580-6.
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  132. Devor M, Papir-Kricheli D, Nachmias E, Rosenthal F, Gilon C, Chorev M, Selinger Z. Substance P-induced cutaneous plasma extravasation in rats is mediated by NK-1 tachykinin receptors. Neurosci Lett. 1989 Aug 28; 103(2):203-8.
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  133. Shechter Y, Yaish P, Chorev M, Gilon C, Braun S, Levitzki A. Inhibition of insulin-dependent lipogenesis and anti-lipolysis by protein tyrosine kinase inhibitors. EMBO J. 1989 Jun; 8(6):1671-6.
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  134. Levian-Teitelbaum D, Kolodny N, Chorev M, Selinger Z, Gilon C. 1H-NMR studies of receptor-selective substance P analogues reveal distinct predominant conformations in DMSO-d6. Biopolymers. 1989 Jan; 28(1):51-64.
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  135. Goldman ME, McKee RL, Caulfield MP, Reagan JE, Levy JJ, Gay CT, DeHaven PA, Rosenblatt M, Chorev M. A new highly potent parathyroid hormone antagonist: [D-Trp12,Tyr34]bPTH-(7-34)NH2. Endocrinology. 1988 Nov; 123(5):2597-9.
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  136. Goldman ME, Chorev M, Reagan JE, Nutt RF, Levy JJ, Rosenblatt M. Evaluation of novel parathyroid hormone analogs using a bovine renal membrane receptor binding assay. Endocrinology. 1988 Sep; 123(3):1468-75.
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  137. Hanani M, Chorev M, Gilon C, Selinger Z. The actions of receptor-selective substance P analogs on myenteric neurons: an electrophysiological investigation. Eur J Pharmacol. 1988 Aug 24; 153(2-3):247-53.
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  138. Laufer R, Gilon C, Chorev M, Selinger Z. Desensitization with a selective agonist discriminates between multiple tachykinin receptors. J Pharmacol Exp Ther. 1988 May; 245(2):639-43.
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  139. Ewenson A, Laufer R, Chorev M, Selinger Z, Gilon C. Dehydro keto methylene and keto methylene analogues of substance P. Synthesis and biological activity. J Med Chem. 1988 Feb; 31(2):416-21.
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  140. Silkoff P, Karmeli F, Goldin E, Ewenson A, Gilon C, Chorev M, Laufer R, Selinger Z, Rachmilewitz D. Effect of substance P on rat gastrointestinal transit. Dig Dis Sci. 1988 Jan; 33(1):74-7.
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  141. Papir-Kricheli D, Frey J, Laufer R, Gilon C, Chorev M, Selinger Z, Devor M. Behavioural effects of receptor-specific substance P agonists. Pain. 1987 Nov; 31(2):263-76.
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  142. Wormser U, Laufer R, Hart Y, Chorev M, Gilon C, Selinger Z. Highly selective agonists for substance P receptor subtypes. EMBO J. 1986 Nov; 5(11):2805-8.
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  143. Chorev M, Rubini E, Hart Y, Gilon C, Wormser U, Selinger Z. Metabolically stable analogues of substance P: persistent action of partially modified retro-inverso analogues of substance P on rat parotid and hypothalamic slices. Eur J Pharmacol. 1986 Aug 15; 127(3):187-95.
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  144. Laufer R, Gilon C, Chorev M, Selinger Z. Characterization of a neurokinin B receptor site in rat brain using a highly selective radioligand. J Biol Chem. 1986 Aug 5; 261(22):10257-63.
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  145. Laufer R, Gilon C, Chorev M, Selinger Z. [pGlu6,Pro9]SP6-11, a selective agonist for the substance P P-receptor subtype. J Med Chem. 1986 Jul; 29(7):1284-8.
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  146. Bar-Sinai A, Aldouby Y, Chorev M, Levitzki A. Association of turkey erythrocyte beta-adrenoceptors with a specific lipid component. EMBO J. 1986 Jun; 5(6):1175-80.
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  147. Eckart K, Schwarz H, Chorev M, Gilon C. Sequence determination of N-terminal and C-terminal blocked peptides containing N-alkylated amino acids and structure determination of these amino acid constituents by using fast-atom-bombardment/tandem mass spectrometry. Eur J Biochem. 1986 May 15; 157(1):209-16.
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  148. Wang L, Chorev M, Feingers J, Levitzki A, Inbar M. Stereospecific antibodies to propranolol. FEBS Lett. 1986 Apr 21; 199(2):173-8.
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  149. Ewenson A, Laufer R, Chorev M, Selinger Z, Gilon C. Ketomethylene pseudopeptide analogues of substance P: synthesis and biological activity. J Med Chem. 1986 Feb; 29(2):295-9.
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  150. Friedman ZY, Wormser U, Rubini E, Chorev M, Gilon C, Selinger Z. Desensitization of substance P-induced K+ release in rat parotid. Eur J Pharmacol. 1985 Nov 19; 117(3):323-8.
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  151. Laufer R, Wormser U, Friedman ZY, Gilon C, Chorev M, Selinger Z. Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proc Natl Acad Sci U S A. 1985 Nov; 82(21):7444-8.
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  152. Laufer R, Ewenson A, Gilon C, Chorev M, Selinger Z. Inhibition of substance P degradation in rat brain preparations by peptide hydroxamic acids. Eur J Biochem. 1985 Jul 1; 150(1):135-40.
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  153. Chorev M, Feigenbaum A, Keenan AK, Gilon C, Levitzki A. N-Bromoacetyl-amino-cyanopindolol: a highly potent beta-adrenergic affinity label blocks irreversibly a non-protein component tightly associated with the receptor. Eur J Biochem. 1985 Jan 2; 146(1):9-14.
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  154. Laufer R, Wormser U, Selinger Z, Chorev M, Gilon C. Ion-exchange chromatographic assay of peptidases acting on the C-terminal hexapeptide sequence of substance P. J Chromatogr. 1984 Oct 5; 301(2):415-24.
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  155. Wormser U, Chorev M, Gilon C, Laufer R, Friedman ZY, Selinger Z. Substance P degrading systems of rat parotid and hypothalamus. Biochim Biophys Acta. 1984 Mar 22; 798(1):28-36.
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  156. Rachmilewitz D, Karmeli F, Chorev M, Selinger Z. Effect of opiates on human colonic adenylate cyclase activity. Eur J Pharmacol. 1983 Sep 30; 93(3-4):169-73.
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  157. Stern PS, Chorev M, Goodman M, Hagler AT. Computer simulation of the conformational properties of retro-inverso peptides. I. Empirical force field calculations of rigid and flexible geometries of N-acetylglycine-N'-methylamide, bis(acetamido) methane, and N,N'-dimethylmalonamide and their corresponding C alpha-methylated analogs. Biopolymers. 1983 Aug; 22(8):1885-900.
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  158. Ribeiro A, Chorev M, Goodman M. Proton NMR studies of partially modified retro- inverso peptides. Biopolymers. 1983 Aug; 22(8):1869-83.
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  159. Stern PS, Chorev M, Goodman M, Hagler AT. Computer simulation of the conformational properties of retro-inverso peptides. II. Ab initio study, spatial electron distribution, and population analysis of N-formylglycine methylamide, N-formyl N'-acetyldiaminomethane, and N-methylmalonamide. Biopolymers. 1983 Aug; 22(8):1901-7.
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  160. Chorev M, Goodman M. Partially modified retro-inverso peptides. Comparative Curtius rearrangements to prepare 1,1-diaminoalkane derivatives. Int J Pept Protein Res. 1983 Mar; 21(3):258-68.
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  161. Chorev M, Rubini E, Gilon C, Wormser U, Selinger Z. Synthesis of partially modified retro-inverso substance P analogues and their biological activity. J Med Chem. 1983 Feb; 26(2):129-35.
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  162. Deutsch J, Gilon C, Chorev M. Field desorption mass spectrometry. II. Potassium cationization field desorption mass spectrometry of some penta- and hexapeptides derived from substance P. Int J Pept Protein Res. 1981 Aug; 18(2):203-7.
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  163. Laufer R, Chorev M, Gilon C, Friedman ZY, Wormser U, Selinger Z. Persistent action of N-methylated analogs of substance P on rat parotid slices. FEBS Lett. 1981 Jan 26; 123(2):291-4.
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  164. MacDonald SA, Willson CG, Chorev M, Vernacchia FS, Goodman M. Peptide sweeteners. 3. Effect of modifying the peptide bond on the sweet taste of L-aspartyl-L-phenylalanine methyl ester and its analogues. J Med Chem. 1980 Apr; 23(4):413-20.
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  165. Kawai M, Chorev M, Marin-Rose J, Goodman M. Peptide sweeteners. 4. Hydroxy and methoxy substitution of the aromatic ring in L-aspartyl-L-phenylalanine methyl ester. Structure-taste relationships. J Med Chem. 1980 Apr; 23(4):420-4.
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  166. Chorev M, Shavitz R, Goodman M, Minick S, Guillemin R. Partially modified retro-inverso-enkephalinamides: topochemical long-acting analogs in vitro and in vivo. Science. 1979 Jun 15; 204(4398):1210-2.
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  167. Klausner YS, Chorev M. Crown ethers as catalysts of fluoride-anion-mediated reactions in peptide synthesis. Part 1. Protection of tryptophan by benzyloxy-carbonyl and 2,4-dichlorobenzyloxycarbonyl groups. J Chem Soc Perkin 1. 1977; (6):627-31.
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