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Hajime Sasaki, PH.D., D.D.S.

TitleInstructor in Oral Medicine, Infection, and Immunity
InstitutionForsyth Institute
DepartmentOral Med - Infection + Immunity
AddressForsyth Institute
245 1st Street
Cambridge MA 02142
Fax617/262-4021

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sugawara K, Takahashi H, Kashiwagura T, Yamada K, Yanagida S, Homma M, Dairiki K, Sasaki H, Kawagoshi A, Satake M, Shioya T. Effect of anti-inflammatory supplementation with whey peptide and exercise therapy in patients with COPD. Respir Med. 2012 Nov; 106(11):1526-34.
    View in: PubMed
  2. Izard J, Sasaki H, Kent R. Pathogenicity of Treponema denticola Wild-Type and Mutant Strain Tested by an Active Mode of Periodontal Infection Using Microinjection. Int J Dent. 2012; 2012:549169.
    View in: PubMed
  3. Hotta K, Fukasawa Y, Sasaki H, Seki T, Togashi M, Harada H. Granulomatous tubulointerstitial nephritis in a renal allograft: three cases report and review of literature. Clin Transplant. 2012 Jul; 26 Suppl 24:70-5.
    View in: PubMed
  4. Iwami D, Harada H, Morita K, Oba K, Fukuzawa N, Hotta K, Sasaki H, Miyazaki C, Nonomura K. Preservation of deep inferior epigastric artery at kidney transplantation prevents atrophy of lower rectus abdominis muscle. Transplantation. 2012 May 27; 93(10):1013-6.
    View in: PubMed
  5. Silva MJ, Kajiya M, AlShwaimi E, Sasaki H, Hong J, Ok P, Rezende TM, Pagonis TC, White RR, Paster BJ, Stashenko P, Kawai T. Bacteria-reactive immune response may induce RANKL-expressing T cells in the mouse periapical bone loss lesion. J Endod. 2012 Mar; 38(3):346-50.
    View in: PubMed
  6. Kume H, Okazaki K, Yamaji T, Sasaki H. A newly designed enteral formula containing whey peptides and fermented milk product protects mice against concanavalin A-induced hepatitis by suppressing overproduction of inflammatory cytokines. Clin Nutr. 2012 Apr; 31(2):283-9.
    View in: PubMed
  7. Onoe T, Honda M, Matsuo K, Sasaki H, Sawamura M, Onoe Y, Iwamoto A, Onodera S, Kawana T, Tada Y, Nimura M, Nakagawa H. Examination of the correlation between the manual and automated serological testing methods for syphilis. J Dermatol. 2012 Apr; 39(4):355-61.
    View in: PubMed
  8. Yamazaki M, Minami Y, Sasaki H, Sumi M. The psychosocial response to the 2011 Tohoku earthquake. Bull World Health Organ. 2011 Sep 1; 89(9):623.
    View in: PubMed
  9. Takayanagi T, Sasaki H, Kawashima A, Mizuochi Y, Hirate H, Sugiura T, Azami T, Asai K, Sobue K. A new enteral diet, MHN-02, which contains abundant antioxidants and whey peptide, protects against carbon tetrachloride-induced hepatitis. JPEN J Parenter Enteral Nutr. 2011 Jul; 35(4):516-22.
    View in: PubMed
  10. Amo K, Arai H, Uebanso T, Fukaya M, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Takeda E. Effects of xylitol on metabolic parameters and visceral fat accumulation. J Clin Biochem Nutr. 2011 Jul; 49(1):1-7.
    View in: PubMed
  11. Shirakawa J, Amo K, Ohminami H, Orime K, Togashi Y, Ito Y, Tajima K, Koganei M, Sasaki H, Takeda E, Terauchi Y. Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased ß cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetes. J Biol Chem. 2011 Jul 22; 286(29):25467-76.
    View in: PubMed
  12. Abe T, Harabayashi T, Shinohara N, Sazawa A, Maruyama S, Sasaki H, Nonomura K. Outcome of regional lymph node dissection in conjunction with laparoscopic nephroureterectomy for urothelial carcinoma of the upper urinary tract. J Endourol. 2011 May; 25(5):803-7.
    View in: PubMed
  13. Shirakawa J, Fujii H, Ohnuma K, Sato K, Ito Y, Kaji M, Sakamoto E, Koganei M, Sasaki H, Nagashima Y, Amo K, Aoki K, Morimoto C, Takeda E, Terauchi Y. Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice. Diabetes. 2011 Apr; 60(4):1246-57.
    View in: PubMed
  14. Nakamura K, Ogawa S, Dairiki K, Fukatsu K, Sasaki H, Kaneko T, Yamaji T. A new immune-modulating diet enriched with whey-hydrolyzed peptide, fermented milk, and isomaltulose attenuates gut ischemia-reperfusion injury in mice. Clin Nutr. 2011 Aug; 30(4):513-6.
    View in: PubMed
  15. Tonouchi H, Yamaji T, Uchida M, Koganei M, Sasayama A, Kaneko T, Urita Y, Okuno M, Suzuki K, Kashimura J, Sasaki H. Studies on absorption and metabolism of palatinose (isomaltulose) in rats. Br J Nutr. 2011 Jan; 105(1):10-4.
    View in: PubMed
  16. Xu Y, Morse LR, da Silva RA, Odgren PR, Sasaki H, Stashenko P, Battaglino RA. PAMM: a redox regulatory protein that modulates osteoclast differentiation. Antioxid Redox Signal. 2010 Jul 1; 13(1):27-37.
    View in: PubMed
  17. Makino S, Ikegami S, Kume A, Horiuchi H, Sasaki H, Orii N. Reducing the risk of infection in the elderly by dietary intake of yoghurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1. Br J Nutr. 2010 Oct; 104(7):998-1006.
    View in: PubMed
  18. Rittling SR, Zetterberg C, Yagiz K, Skinner S, Suzuki N, Fujimura A, Sasaki H. Protective role of osteopontin in endodontic infection. Immunology. 2010 Jan; 129(1):105-14.
    View in: PubMed
  19. Alshwaimi E, Purcell P, Kawai T, Sasaki H, Oukka M, Campos-Neto A, Stashenko P. Regulatory T cells in mouse periapical lesions. J Endod. 2009 Sep; 35(9):1229-33.
    View in: PubMed
  20. Sakuma M, Arai H, Mizuno A, Fukaya M, Matsuura M, Sasaki H, Yamanaka-Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E. Improvement of glucose metabolism in patients with impaired glucose tolerance or diabetes by long-term administration of a palatinose-based liquid formula as a part of breakfast. J Clin Biochem Nutr. 2009 Sep; 45(2):155-62.
    View in: PubMed
  21. Niwano Y, Adachi T, Kashimura J, Sakata T, Sasaki H, Sekine K, Yamamoto S, Yonekubo A, Kimura S. Is glycemic index of food a feasible predictor of appetite, hunger, and satiety? J Nutr Sci Vitaminol (Tokyo). 2009 Jun; 55(3):201-7.
    View in: PubMed
  22. Iyo M, Shiina A, Matsubara S, Kawada K, Yoshikawa A, Mibe Y, Hata M, Fukushima H, Iwasaki Y, Komiya H, Komiyama T, Haebara Y, Shinoda M, Sasaki H, Hazama K, Satake N. [Understanding of the actual state and optimization of psychiatric care to hasten hospital discharge]. Seishin Shinkeigaku Zasshi. 2009; 111(9):1165-70.
    View in: PubMed
  23. Sato K, Arai H, Miyazawa Y, Fukaya M, Uebanso T, Koganei M, Sasaki H, Sato T, Yamamoto H, Taketani Y, Takeda E. Palatinose and oleic acid act together to prevent pancreatic islet disruption in nondiabetic obese Zucker rats. J Med Invest. 2008 Aug; 55(3-4):183-95.
    View in: PubMed
  24. Sasaki H, Suzuki N, Kent R, Kawashima N, Takeda J, Stashenko P. T cell response mediated by myeloid cell-derived IL-12 is responsible for Porphyromonas gingivalis-induced periodontitis in IL-10-deficient mice. J Immunol. 2008 May 1; 180(9):6193-8.
    View in: PubMed
  25. Leshem O, Kashino SS, Gonçalves RB, Suzuki N, Onodera M, Fujimura A, Sasaki H, Stashenko P, Campos-Neto A. Th1 biased response to a novel Porphyromonas gingivalis protein aggravates bone resorption caused by this oral pathogen. Microbes Infect. 2008 May; 10(6):664-72.
    View in: PubMed
  26. Yui S, Sasaki H, Bito Y, Ban H, Kitamura M, Nakashima T, Obara T. Resource management simulator for radiology departments. AMIA Annu Symp Proc. 2007; 1165.
    View in: PubMed
  27. Battaglino RA, Pham L, Morse LR, Vokes M, Sharma A, Odgren PR, Yang M, Sasaki H, Stashenko P. NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts. Bone. 2008 Jan; 42(1):180-92.
    View in: PubMed
  28. Sato K, Arai H, Mizuno A, Fukaya M, Sato T, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Doi T, Takeda E. Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats. J Nutr. 2007 Aug; 137(8):1908-15.
    View in: PubMed
  29. Oizumi T, Daimon M, Jimbu Y, Kameda W, Arawaka N, Yamaguchi H, Ohnuma H, Sasaki H, Kato T. A palatinose-based balanced formula improves glucose tolerance, serum free fatty acid levels and body fat composition. Tohoku J Exp Med. 2007 Jun; 212(2):91-9.
    View in: PubMed
  30. Kawai T, Paster BJ, Komatsuzawa H, Ernst CW, Goncalves RB, Sasaki H, Ouhara K, Stashenko PP, Sugai M, Taubman MA. Cross-reactive adaptive immune response to oral commensal bacteria results in an induction of receptor activator of nuclear factor-kappaB ligand (RANKL)-dependent periodontal bone resorption in a mouse model. Oral Microbiol Immunol. 2007 Jun; 22(3):208-15.
    View in: PubMed
  31. Hagiwara M, Sasaki H, Matsuo K, Honda M, Kawase M, Nakagawa H. Loop-mediated isothermal amplification method for detection of human papillomavirus type 6, 11, 16, and 18. J Med Virol. 2007 May; 79(5):605-15.
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  32. Matsuo K, Arai H, Muto K, Fukaya M, Sato T, Mizuno A, Sakuma M, Yamanaka-Okumura H, Sasaki H, Yamamoto H, Taketani Y, Doi T, Takeda E. The Anti-Obesity Effect of the Palatinose-Based Formula Inslow is Likely due to an Increase in the Hepatic PPAR-alpha and Adipocyte PPAR-gamma Gene Expressions. J Clin Biochem Nutr. 2007 May; 40(3):234-41.
    View in: PubMed
  33. Fujiwara T, Naomoto Y, Motoki T, Shigemitsu K, Shirakawa Y, Yamatsuji T, Kataoka M, Haisa M, Fujiwara T, Egi M, Morimatsu H, Hanazaki M, Katayama H, Morita K, Mizumoto K, Asou T, Arima H, Sasaki H, Matsuura M, Gunduz M, Tanaka N. Effects of a novel palatinose based enteral formula (MHN-01) carbohydrate-adjusted fluid diet in improving the metabolism of carbohydrates and lipids in patients with esophageal cancer complicated by diabetes mellitus. J Surg Res. 2007 Apr; 138(2):231-40.
    View in: PubMed
  34. Stashenko P, Gonçalves RB, Lipkin B, Ficarelli A, Sasaki H, Campos-Neto A. Th1 immune response promotes severe bone resorption caused by Porphyromonas gingivalis. Am J Pathol. 2007 Jan; 170(1):203-13.
    View in: PubMed
  35. Arai H, Mizuno A, Sakuma M, Fukaya M, Matsuo K, Muto K, Sasaki H, Matsuura M, Okumura H, Yamamoto H, Taketani Y, Doi T, Takeda E. Effects of a palatinose-based liquid diet (Inslow) on glycemic control and the second-meal effect in healthy men. Metabolism. 2007 Jan; 56(1):115-21.
    View in: PubMed
  36. Mizuha Y, Yamamoto H, Sato T, Tsuji M, Masuda M, Uchida M, Sakai K, Taketani Y, Yasutomo K, Sasaki H, Takeda E. Water extract of Cordyceps sinensis (WECS) inhibits the RANKL-induced osteoclast differentiation. Biofactors. 2007; 30(2):105-16.
    View in: PubMed
  37. Sato T, Yamamoto H, Sawada N, Nashiki K, Tsuji M, Muto K, Kume H, Sasaki H, Arai H, Nikawa T, Taketani Y, Takeda E. Restraint stress alters the duodenal expression of genes important for lipid metabolism in rat. Toxicology. 2006 Oct 29; 227(3):248-61.
    View in: PubMed
  38. Foschi F, Izard J, Sasaki H, Sambri V, Prati C, Müller R, Stashenko P. Treponema denticola in disseminating endodontic infections. J Dent Res. 2006 Aug; 85(8):761-5.
    View in: PubMed
  39. Kume H, Sasaki H, Kano-Sueoka T. Serum ethanolamine and hepatocyte proliferation in perinatal and partially hepatectomized rats. Life Sci. 2006 Sep 27; 79(18):1764-72.
    View in: PubMed
  40. Kume H, Okazaki K, Sasaki H. Hepatoprotective effects of whey protein on D-galactosamine-induced hepatitis and liver fibrosis in rats. Biosci Biotechnol Biochem. 2006 May; 70(5):1281-5.
    View in: PubMed
  41. Kume H, Sasaki H. Ethanolamine modulates DNA synthesis through epidermal growth factor receptor in rat primary hepatocytes. In Vitro Cell Dev Biol Anim. 2006 Jan-Feb; 42(1-2):20-6.
    View in: PubMed
  42. Sasaki H, Okamatsu Y, Kawai T, Kent R, Taubman M, Stashenko P. The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss. J Periodontal Res. 2004 Dec; 39(6):432-41.
    View in: PubMed
  43. Okamatsu Y, Kim D, Battaglino R, Sasaki H, Späte U, Stashenko P. MIP-1 gamma promotes receptor-activator-of-NF-kappa-B-ligand-induced osteoclast formation and survival. J Immunol. 2004 Aug 1; 173(3):2084-90.
    View in: PubMed
  44. Arai H, Mizuno A, Matsuo K, Fukaya M, Sasaki H, Arima H, Matsuura M, Taketani Y, Doi T, Takeda E. Effect of a novel palatinose-based liquid balanced formula (MHN-01) on glucose and lipid metabolism in male Sprague-Dawley rats after short- and long-term ingestion. Metabolism. 2004 Aug; 53(8):977-83.
    View in: PubMed
  45. Ashida K, Sasaki H, Suzuki YA, Lönnerdal B. Cellular internalization of lactoferrin in intestinal epithelial cells. Biometals. 2004 Jun; 17(3):311-5.
    View in: PubMed
  46. Sasaki H, Balto K, Kawashima N, Eastcott J, Hoshino K, Akira S, Stashenko P. Gamma interferon (IFN-gamma) and IFN-gamma-inducing cytokines interleukin-12 (IL-12) and IL-18 do not augment infection-stimulated bone resorption in vivo. Clin Diagn Lab Immunol. 2004 Jan; 11(1):106-10.
    View in: PubMed
  47. Balto K, Sasaki H, Stashenko P. Interleukin-6 deficiency increases inflammatory bone destruction. Infect Immun. 2001 Feb; 69(2):744-50.
    View in: PubMed
  48. Hou L, Sasakj H, Stashenko P. B-Cell deficiency predisposes mice to disseminating anaerobic infections: protection by passive antibody transfer. Infect Immun. 2000 Oct; 68(10):5645-51.
    View in: PubMed
  49. Sasaki H, Hou L, Belani A, Wang CY, Uchiyama T, Müller R, Stashenko P. IL-10, but not IL-4, suppresses infection-stimulated bone resorption in vivo. J Immunol. 2000 Oct 1; 165(7):3626-30.
    View in: PubMed
  50. Hou L, Sasaki H, Stashenko P. Toll-like receptor 4-deficient mice have reduced bone destruction following mixed anaerobic infection. Infect Immun. 2000 Aug; 68(8):4681-7.
    View in: PubMed
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