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Stanley Yang Shaw, Ph.D., M.D.

TitleAssistant Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Center for Systems Biology CPZN-5226
185 Cambridge St
Boston MA 02114
Phone617/324-9631
Fax617/643-6133

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Liao KP, Cai T, Gainer VS, Cagan A, Murphy SN, Liu C, Churchill S, Shaw SY, Kohane I, Solomon DH, Plenge RM, Karlson EW. Lipid and lipoprotein levels and trend in rheumatoid arthritis compared to the general population. Arthritis Care Res (Hoboken). 2013 Dec; 65(12):2046-50.
    View in: PubMed
  2. Liu Y, Shoji-Kawata S, Sumpter RM, Wei Y, Ginet V, Zhang L, Posner B, Tran KA, Green DR, Xavier RJ, Shaw SY, Clarke PG, Puyal J, Levine B. Autosis is a Na+,K+-ATPase-regulated form of cell death triggered by autophagy-inducing peptides, starvation, and hypoxia-ischemia. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20364-71.
    View in: PubMed
  3. Xia Z, Secor E, Chibnik LB, Bove RM, Cheng S, Chitnis T, Cagan A, Gainer VS, Chen PJ, Liao KP, Shaw SY, Ananthakrishnan AN, Szolovits P, Weiner HL, Karlson EW, Murphy SN, Savova GK, Cai T, Churchill SE, Plenge RM, Kohane IS, De Jager PL. Modeling disease severity in multiple sclerosis using electronic health records. PLoS One. 2013; 8(11):e78927.
    View in: PubMed
  4. Shaw SY, Tran K, Castoreno AB, Peloquin JM, Lassen KG, Khor B, Aldrich LN, Tan PH, Graham DB, Kuballa P, Goel G, Daly MJ, Shamji AF, Schreiber SL, Xavier RJ. Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules. ACS Chem Biol. 2013 Dec 20; 8(12):2724-33.
    View in: PubMed
  5. Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY. Microfluidic On-chip Capture-cycloaddition Reaction to Reversibly Immobilize Small Molecules or Multi-component Structures for Biosensor Applications. J Vis Exp. 2013; (79).
    View in: PubMed
  6. Conway KL, Kuballa P, Song JH, Patel KK, Castoreno AB, Yilmaz OH, Jijon HB, Zhang M, Aldrich LN, Villablanca EJ, Peloquin JM, Goel G, Lee IA, Mizoguchi E, Shi HN, Bhan AK, Shaw SY, Schreiber SL, Virgin HW, Shamji AF, Stappenbeck TS, Reinecker HC, Xavier RJ. Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice From Salmonella Infection. Gastroenterology. 2013 Dec; 145(6):1347-57.
    View in: PubMed
  7. Ananthakrishnan AN, Cagan A, Gainer VS, Cai T, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw SY, Churchill S, Karlson EW, Kohane I, Plenge RM, Murphy SN, Liao KP. Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease. Inflamm Bowel Dis. 2013 Aug; 19(9):1921-7.
    View in: PubMed
  8. Ananthakrishnan AN, Cai T, Savova G, Cheng SC, Chen P, Perez RG, Gainer VS, Murphy SN, Szolovits P, Xia Z, Shaw S, Churchill S, Karlson EW, Kohane I, Plenge RM, Liao KP. Improving case definition of Crohn's disease and ulcerative colitis in electronic medical records using natural language processing: a novel informatics approach. Inflamm Bowel Dis. 2013 Jun; 19(7):1411-20.
    View in: PubMed
  9. Ge Y, Cheng S, Larson MG, Ghorbani A, Martin RP, Klein RJ, O'Donnell CJ, Vasan RS, Shaw SY, Wang TJ, Cohen KS. Circulating CD31+ leukocyte frequency is associated with cardiovascular risk factors. Atherosclerosis. 2013 Jul; 229(1):228-33.
    View in: PubMed
  10. Liu R, Rallo R, Weissleder R, Tassa C, Shaw S, Cohen Y. Nano-SAR Development for Bioactivity of Nanoparticles with Considerations of Decision Boundaries. Small. 2013 May 27; 9(9-10):1842-52.
    View in: PubMed
  11. Ananthakrishnan AN, Gainer VS, Cai T, Perez RG, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw S, Churchill S, Karlson EW, Kohane I, Perlis RH, Plenge RM, Murphy SN, Liao KP. Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis. Am J Gastroenterol. 2013 Apr; 108(4):594-601.
    View in: PubMed
  12. Ananthakrishnan AN, Gainer VS, Perez RG, Cai T, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw SY, Churchill S, Karlson EW, Kohane I, Perlis RH, Plenge RM, Murphy SN, Liao KP. Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease. Aliment Pharmacol Ther. 2013 Feb; 37(4):445-54.
    View in: PubMed
  13. Cohen KS, Cheng S, Larson MG, Cupples LA, McCabe EL, Wang YA, Ngwa JS, Martin RP, Klein RJ, Hashmi B, Ge Y, O'Donnell CJ, Vasan RS, Shaw SY, Wang TJ. Circulating CD34+ progenitor cell frequency is associated with clinical and genetic factors. Blood. 2013 Feb 21; 121(8):e50-6.
    View in: PubMed
  14. Epa VC, Burden FR, Tassa C, Weissleder R, Shaw S, Winkler DA. Modeling biological activities of nanoparticles. Nano Lett. 2012 Nov 14; 12(11):5808-12.
    View in: PubMed
  15. Chong NW, Koekemoer AL, Ounzain S, Samani NJ, Shin JT, Shaw SY. STARS is essential to maintain cardiac development and function in vivo via a SRF pathway. PLoS One. 2012; 7(7):e40966.
    View in: PubMed
  16. Tassa C, Liong M, Hilderbrand S, Sandler JE, Reiner T, Keliher EJ, Weissleder R, Shaw SY. On-chip bioorthogonal chemistry enables immobilization of in situ modified nanoparticles and small molecules for label-free monitoring of protein binding and reaction kinetics. Lab Chip. 2012 Sep 7; 12(17):3103-10.
    View in: PubMed
  17. Shaw SY, Brettman AD. Phenotyping patient-derived cells for translational studies in cardiovascular disease. Circulation. 2011 Nov 29; 124(22):2444-55.
    View in: PubMed
  18. Agasti SS, Liong M, Tassa C, Chung HJ, Shaw SY, Lee H, Weissleder R. Supramolecular host-guest interaction for labeling and detection of cellular biomarkers. Angew Chem Int Ed Engl. 2012 Jan 9; 51(2):450-4.
    View in: PubMed
  19. Cheng S, Wang N, Larson MG, Palmisano JN, Mitchell GF, Benjamin EJ, Vasan RS, Levy D, McCabe EL, Vita JA, Wang TJ, Shaw SY, Cohen KS, Hamburg NM. Circulating angiogenic cell populations, vascular function, and arterial stiffness. Atherosclerosis. 2012 Jan; 220(1):145-50.
    View in: PubMed
  20. Liong M, Tassa C, Shaw SY, Lee H, Weissleder R. Multiplexed magnetic labeling amplification using oligonucleotide hybridization. Adv Mater. 2011 Sep 22; 23(36):H254-7.
    View in: PubMed
  21. Chen HH, Feng Y, Zhang M, Chao W, Josephson L, Shaw SY, Sosnovik DE. Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5. Nanomedicine. 2012 Apr; 8(3):291-8.
    View in: PubMed
  22. Tassa C, Shaw SY, Weissleder R. Dextran-coated iron oxide nanoparticles: a versatile platform for targeted molecular imaging, molecular diagnostics, and therapy. Acc Chem Res. 2011 Oct 18; 44(10):842-52.
    View in: PubMed
  23. Shaw SY, Cheng S, Cupples LA, Larson MG, McCabe EL, Ngwa JS, Wang YA, Martin RP, Klein RJ, Hashmi B, Ajijola OA, Lau E, O'Donnell CJ, Vasan RS, Cohen KS, Wang TJ. Genetic and clinical correlates of early-outgrowth colony-forming units. Circ Cardiovasc Genet. 2011 Jun; 4(3):296-304.
    View in: PubMed
  24. Reis SA, Thompson MN, Lee JM, Fossale E, Kim HH, Liao JK, Moskowitz MA, Shaw SY, Dong L, Haggarty SJ, MacDonald ME, Seong IS. Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis. Hum Mol Genet. 2011 Jun 15; 20(12):2344-55.
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  25. Shaw SY, Blodgett DM, Ma MS, Westly EC, Clemons PA, Subramanian A, Schreiber SL. Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes. Proc Natl Acad Sci U S A. 2011 Jan 11; 108(2):492-7.
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  26. Fourches D, Pu D, Tassa C, Weissleder R, Shaw SY, Mumper RJ, Tropsha A. Quantitative nanostructure-activity relationship modeling. ACS Nano. 2010 Oct 26; 4(10):5703-12.
    View in: PubMed
  27. Cheng S, Cohen KS, Shaw SY, Larson MG, Hwang SJ, McCabe EL, Martin RP, Klein RJ, Hashmi B, Hoffmann U, Fox CS, Vasan RS, O'Donnell CJ, Wang TJ. Association of colony-forming units with coronary artery and abdominal aortic calcification. Circulation. 2010 Sep 21; 122(12):1176-82.
    View in: PubMed
  28. Tassa C, Duffner JL, Lewis TA, Weissleder R, Schreiber SL, Koehler AN, Shaw SY. Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles. Bioconjug Chem. 2010 Jan; 21(1):14-9.
    View in: PubMed
  29. Shaw SY. Molecular imaging in cardiovascular disease: targets and opportunities. Nat Rev Cardiol. 2009 Sep; 6(9):569-79.
    View in: PubMed
  30. Kelly KA, Shaw SY, Nahrendorf M, Kristoff K, Aikawa E, Schreiber SL, Clemons PA, Weissleder R. Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries. Integr Biol (Camb). 2009 Apr; 1(4):311-7.
    View in: PubMed
  31. Choy E, Yelensky R, Bonakdar S, Plenge RM, Saxena R, De Jager PL, Shaw SY, Wolfish CS, Slavik JM, Cotsapas C, Rivas M, Dermitzakis ET, Cahir-McFarland E, Kieff E, Hafler D, Daly MJ, Altshuler D. Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines. PLoS Genet. 2008 Nov; 4(11):e1000287.
    View in: PubMed
  32. Shaw SY, Westly EC, Pittet MJ, Subramanian A, Schreiber SL, Weissleder R. Perturbational profiling of nanomaterial biologic activity. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7387-92.
    View in: PubMed
  33. Shaw SY. Chemical biology approaches to molecular imaging. Molecular imaging: Principles and practice (R Weissleder, S Gambhir, BD Ross, A Rehemtulla, eds.). 2008.
  34. Shaw SY, Westly EC, Subramanian A, Clemons PA, Schreiber SL. Chemical profiling of human cells to reveal functional consequences of human disease mutations. Abstracts of papers presented at the 2006 meeting on The Biology of Genomes. 2006; 284.
  35. Samani NJ, Mahadeva H, Chong N, Shaw SY. Knockdown in zebrafish supports an important role for myocyte stress (ms1) in cardiac development and function. European Heart Journal. 2006; 27(1):473.
  36. Low AF, O'Donnell CJ, Kathiresan S, Everett B, Chae CU, Shaw SY, Ellinor PT, MacRae CA. Aging syndrome genes and premature coronary artery disease. BMC Med Genet. 2005 Oct 31; 6:38.
    View in: PubMed
  37. Peterson RT, Shaw SY, Peterson TA, Milan DJ, Zhong TP, Schreiber SL, MacRae CA, Fishman MC. Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat Biotechnol. 2004 May; 22(5):595-9.
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  38. Lee WS, Jain MK, Arkonac BM, Zhang D, Shaw SY, Kashiki S, Maemura K, Lee SL, Hollenberg NK, Lee ME, Haber E. Thy-1, a novel marker for angiogenesis upregulated by inflammatory cytokines. Circ Res. 1998 May 4; 82(8):845-51.
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  39. Shaw SY, Wang JC. Chirality of DNA trefoils: implications in intramolecular synapsis of distant DNA segments. Proc Natl Acad Sci U S A. 1997 Mar 4; 94(5):1692-7.
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  40. Schildbach JF, Shaw SY, Bruccoleri RE, Haber E, Herzenberg LA, Jager GC, Jeffrey PD, Panka DJ, Parks DR, Near RI, et al. Contribution of a single heavy chain residue to specificity of an anti-digoxin monoclonal antibody. Protein Sci. 1994 May; 3(5):737-49.
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  41. Shaw SY, Wang JC. DNA knot formation in aqueous solutions. Random Knotting and Linking. 1994; 55-66.
  42. Shaw SY, Wang JC. DNA knot formation in aqueous solutions. Journal of Knot Theory and its Ramifications. 1994; 3:287-294.
  43. Shaw SY, Wang JC. Knotting of a DNA chain during ring closure. Science. 1993 Apr 23; 260(5107):533-6.
    View in: PubMed
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