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Deborah Jean Culley, M.D.

TitleAssociate Professor of Anaesthesia
InstitutionBrigham and Women's Hospital
DepartmentAnaesthesia
AddressBrigham and Women's Hospital
Anesthesiology, Perioperative & Pain Mgt
75 Francis St
Boston MA 02115
Phone617/732-7330
Fax617/730-2813

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Sci Rep. 2014; 4:3766.
    View in: PubMed
  2. Culley DJ, Fahy BG, Xie Z, Lekowski R, Buetler S, Liu X, Cohen NH, Crosby G. Academic Productivity of Directors of ACGME-Accredited Residency Programs in Surgery and Anesthesiology. Anesth Analg. 2014 Jan; 118(1):200-5.
    View in: PubMed
  3. Culley DJ, Cotran EK, Karlsson E, Palanisamy A, Boyd JD, Xie Z, Crosby G. Isoflurane affects the cytoskeleton but not survival, proliferation, or synaptogenic properties of rat astrocytes in vitro. Br J Anaesth. 2013 Jun; 110 Suppl 1:i19-i28.
    View in: PubMed
  4. Jevtovic-Todorovic V, Absalom AR, Blomgren K, Brambrink A, Crosby G, Culley DJ, Fiskum G, Giffard RG, Herold KF, Loepke AW, Ma D, Orser BA, Planel E, Slikker W, Soriano SG, Stratmann G, Vutskits L, Xie Z, Hemmings HC. Anaesthetic neurotoxicity and neuroplasticity: an expert group report and statement based on the BJA Salzburg Seminar. Br J Anaesth. 2013 Aug; 111(2):143-51.
    View in: PubMed
  5. Culley DJ. Report on SNACC's 40th Anniversary Meeting. J Neurosurg Anesthesiol. 2013 Apr; 25(2):221-2.
    View in: PubMed
  6. Zheng H, Dong Y, Xu Z, Crosby G, Culley DJ, Zhang Y, Xie Z. Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice. Anesthesiology. 2013 Mar; 118(3):516-26.
    View in: PubMed
  7. Culley DJ, Sun H, Harman AE, Warner DO. Perceived value of Board certification and the Maintenance of Certification in Anesthesiology Program (MOCA®). J Clin Anesth. 2013 Feb; 25(1):12-9.
    View in: PubMed
  8. Crosby G, Culley DJ. Anesthesia & analgesia by the numbers: then & now. Anesth Analg. 2012 Dec; 115(6):1265-7.
    View in: PubMed
  9. Zhang Y, Xu Z, Wang H, Dong Y, Shi HN, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol. 2012 May; 71(5):687-98.
    View in: PubMed
  10. Crosby G, Culley DJ. Processed electroencephalogram and depth of anesthesia: window to nowhere or into the brain? Anesthesiology. 2012 Feb; 116(2):235-7.
    View in: PubMed
  11. Culley DJ, Maze M, Crosby G. Reprogramming of the infant brain by surgery with general anesthesia. Mayo Clin Proc. 2012 Feb; 87(2):110-3.
    View in: PubMed
  12. Palanisamy A, Crosby G, Culley DJ. In reply. Anesthesiology. 2011 Oct; 115(4):904-5.
    View in: PubMed
  13. Culley DJ, Boyd JD, Palanisamy A, Xie Z, Kojima K, Vacanti CA, Tanzi RE, Crosby G. Isoflurane decreases self-renewal capacity of rat cultured neural stem cells. Anesthesiology. 2011 Oct; 115(4):754-63.
    View in: PubMed
  14. Crosby G, Culley DJ, Hyman BT. Preoperative cognitive assessment of the elderly surgical patient: a call for action. Anesthesiology. 2011 Jun; 114(6):1265-8.
    View in: PubMed
  15. Crosby G, Culley DJ. Surgery and anesthesia: healing the body but harming the brain? Anesth Analg. 2011 May; 112(5):999-1001.
    View in: PubMed
  16. Palanisamy A, Baxter MG, Keel PK, Xie Z, Crosby G, Culley DJ. Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults. Anesthesiology. 2011 Mar; 114(3):521-8.
    View in: PubMed
  17. Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-a, IL-6, and IL-1ß. Neurobiol Aging. 2012 Jul; 33(7):1364-78.
    View in: PubMed
  18. Rudolph JL, Schreiber KA, Culley DJ, McGlinchey RE, Crosby G, Levitsky S, Marcantonio ER. Measurement of post-operative cognitive dysfunction after cardiac surgery: a systematic review. Acta Anaesthesiol Scand. 2010 Jul; 54(6):663-77.
    View in: PubMed
  19. Crosby G, Culley DJ, Patel PM. At the sharp end of spines: anesthetic effects on synaptic remodeling in the developing brain. Anesthesiology. 2010 Mar; 112(3):521-3.
    View in: PubMed
  20. Crosby G, Culley DJ, Marcantonio ER. Delirium: a cognitive cost of the comfort of procedural sedation in elderly patients? Mayo Clin Proc. 2010 Jan; 85(1):12-4.
    View in: PubMed
  21. Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z. The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol. 2009 May; 66(5):620-31.
    View in: PubMed
  22. Baranov D, Bickler PE, Crosby GJ, Culley DJ, Eckenhoff MF, Eckenhoff RG, Hogan KJ, Jevtovic-Todorovic V, Palotás A, Perouansky M, Planel E, Silverstein JH, Wei H, Whittington RA, Xie Z, Zuo Z. Consensus statement: First International Workshop on Anesthetics and Alzheimer's disease. Anesth Analg. 2009 May; 108(5):1627-30.
    View in: PubMed
  23. Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol. 2008 Dec; 64(6):618-27.
    View in: PubMed
  24. Lee IH, Culley DJ, Baxter MG, Xie Z, Tanzi RE, Crosby G. Spatial memory is intact in aged rats after propofol anesthesia. Anesth Analg. 2008 Oct; 107(4):1211-5.
    View in: PubMed
  25. Marcantonio ER, Aneja J, Jones RN, Alsop DC, Fong TG, Crosby GJ, Culley DJ, Cupples LA, Inouye SK. Maximizing clinical research participation in vulnerable older persons: identification of barriers and motivators. J Am Geriatr Soc. 2008 Aug; 56(8):1522-7.
    View in: PubMed
  26. Rudolph JL, Marcantonio ER, Culley DJ, Silverstein JH, Rasmussen LS, Crosby GJ, Inouye SK. Delirium is associated with early postoperative cognitive dysfunction. Anaesthesia. 2008 Sep; 63(9):941-7.
    View in: PubMed
  27. Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci. 2008 Apr 23; 28(17):4551-60.
    View in: PubMed
  28. Culley DJ, Crosby G. Nitrous oxide in neuroanesthesia: tried and true or toxin? Anesthesiology. 2008 Apr; 108(4):553-4.
    View in: PubMed
  29. Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z. The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem. 2008 May 2; 283(18):11866-75.
    View in: PubMed
  30. Baxter MG, Murphy KL, Crosby G, Culley DJ. Different behavioral effects of neurotoxic dorsal hippocampal lesions placed under either isoflurane or propofol anesthesia. Hippocampus. 2008; 18(3):245-50.
    View in: PubMed
  31. Culley DJ, Xie Z, Crosby G. General anesthetic-induced neurotoxicity: an emerging problem for the young and old? Curr Opin Anaesthesiol. 2007 Oct; 20(5):408-13.
    View in: PubMed
  32. Culley DJ, Raghavan SV, Waly M, Baxter MG, Yukhananov R, Deth RC, Crosby G. Nitrous oxide decreases cortical methionine synthase transiently but produces lasting memory impairment in aged rats. Anesth Analg. 2007 Jul; 105(1):83-8.
    View in: PubMed
  33. Culley DJ, Crosby G, Xie Z, Vacanti CA, Kitz RJ, Zapol WM. Career National Institutes of Health funding and scholarship of chairpersons of academic departments of anesthesiology and surgery. Anesthesiology. 2007 Apr; 106(4):836-42.
    View in: PubMed
  34. Xie Z, Dong Y, Maeda U, Moir RD, Xia W, Culley DJ, Crosby G, Tanzi RE. The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation. J Neurosci. 2007 Feb 7; 27(6):1247-54.
    View in: PubMed
  35. Marcantonio ER, Rudolph JL, Culley D, Crosby G, Alsop D, Inouye SK. Serum biomarkers for delirium. J Gerontol A Biol Sci Med Sci. 2006 Dec; 61(12):1281-6.
    View in: PubMed
  36. Xie Z, Dong Y, Maeda U, Moir R, Inouye SK, Culley DJ, Crosby G, Tanzi RE. Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci. 2006 Dec; 61(12):1300-6.
    View in: PubMed
  37. Culley DJ, Yukhananov RY, Xie Z, Gali RR, Tanzi RE, Crosby G. Altered hippocampal gene expression 2 days after general anesthesia in rats. Eur J Pharmacol. 2006 Nov 7; 549(1-3):71-8.
    View in: PubMed
  38. Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology. 2006 May; 104(5):988-94.
    View in: PubMed
  39. Culley DJ, Loguinov A, Yukhananov R, Crosby G. General anesthesia does not reduce life expectancy in aged rats. Anesth Analg. 2006 Mar; 102(3):956-9.
    View in: PubMed
  40. Crosby C, Culley DJ, Baxter MG, Yukhananov R, Crosby G. Spatial memory performance 2 weeks after general anesthesia in adult rats. Anesth Analg. 2005 Nov; 101(5):1389-92.
    View in: PubMed
  41. Culley DJ, Baxter MG, Crosby CA, Yukhananov R, Crosby G. Impaired acquisition of spatial memory 2 weeks after isoflurane and isoflurane-nitrous oxide anesthesia in aged rats. Anesth Analg. 2004 Nov; 99(5):1393-7; table of contents.
    View in: PubMed
  42. Tran T, Culley DJ, Crosby G. Hemorrhagic stroke after spinal anesthesia and minor surgery. J Clin Anesth. 2004 Jun; 16(4):293-5.
    View in: PubMed
  43. Culley DJ, Baxter MG, Yukhananov R, Crosby G. Long-term impairment of acquisition of a spatial memory task following isoflurane-nitrous oxide anesthesia in rats. Anesthesiology. 2004 Feb; 100(2):309-14.
    View in: PubMed
  44. Culley DJ, Crosby G. Mechanisms of postoperative neurobehavioral deficits and stroke may differ. Anesth Analg. 2003 Aug; 97(2):601; author reply 601.
    View in: PubMed
  45. Culley DJ, Baxter M, Yukhananov R, Crosby G. The memory effects of general anesthesia persist for weeks in young and aged rats. Anesth Analg. 2003 Apr; 96(4):1004-9, table of contents.
    View in: PubMed
  46. Culley DJ, Berger MS, Shaw D, Geyer R. An analysis of factors determining the need for ventriculoperitoneal shunts after posterior fossa tumor surgery in children. Neurosurgery. 1994 Mar; 34(3):402-7; discussion 407-8.
    View in: PubMed
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