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Megan Sykes, M.D.

TitleLecturer on Surgery
InstitutionMassachusetts General Hospital
DepartmentSurgery
AddressMassachusetts General Hospital
TBRC/Bmt Section, Rm 5102
149 13th Street
Charlestown MA 02129
Phone617/726-4070
Fax617/724-9892

 Mentoring 
 completed student projects

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sachs DH, Kawai T, Sykes M. Induction of Tolerance through Mixed Chimerism. Cold Spring Harb Perspect Med. 2014; 4(1).
    View in: PubMed
  2. Kawai T, Sachs DH, Sykes M, Cosimi AB. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med. 2013 May 9; 368(19):1850-2.
    View in: PubMed
  3. Sathaliyawala T, Kubota M, Yudanin N, Turner D, Camp P, Thome JJ, Bickham KL, Lerner H, Goldstein M, Sykes M, Kato T, Farber DL. Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity. 2013 Jan 24; 38(1):187-97.
    View in: PubMed
  4. Li HW, Sachs J, Pichardo C, Bronson R, Zhao G, Sykes M. Nonalloreactive T Cells Prevent Donor Lymphocyte Infusion-Induced Graft-versus-Host Disease by Controlling Microbial Stimuli. J Immunol. 2012 Dec 15; 189(12):5572-81.
    View in: PubMed
  5. Wang H, Yang Y, Wang G, Wang S, Yeap BY, Sykes M, Yang YG. Donor bone marrow-derived T cells inhibit GVHD induced by donor lymphocyte infusion in established mixed allogeneic hematopoietic chimeras. PLoS One. 2012; 7(10):e47120.
    View in: PubMed
  6. Li HW, Sykes M. Emerging concepts in haematopoietic cell transplantation. Nat Rev Immunol. 2012 Jun; 12(6):403-16.
    View in: PubMed
  7. Kalscheuer H, Danzl N, Onoe T, Faust T, Winchester R, Goland R, Greenberg E, Spitzer TR, Savage DG, Tahara H, Choi G, Yang YG, Sykes M. A model for personalized in vivo analysis of human immune responsiveness. Sci Transl Med. 2012 Mar 14; 4(125):125ra30.
    View in: PubMed
  8. Lucas CL, Sykes M. Layers of regulation in induction of mixed chimerism by anti-CD40L. Chimerism. 2011 Oct-Dec; 2(4):111-3.
    View in: PubMed
  9. Sykes M, Levy G. Advances in transplantation. Semin Immunol. 2011 Aug; 23(4):222-3.
    View in: PubMed
  10. Onoe T, Kalscheuer H, Danzl N, Chittenden M, Zhao G, Yang YG, Sykes M. Human natural regulatory T cell development, suppressive function, and postthymic maturation in a humanized mouse model. J Immunol. 2011 Oct 1; 187(7):3895-903.
    View in: PubMed
  11. Sachs DH, Sykes M, Kawai T, Cosimi AB. Immuno-intervention for the induction of transplantation tolerance through mixed chimerism. Semin Immunol. 2011 Jun; 23(3):165-73.
    View in: PubMed
  12. Levesque V, Bardwell PD, Shimizu I, Haspot F, Benichou G, Yeap BY, Sykes M. B-cell-dependent memory T cells impede nonmyeloablative mixed chimerism induction in presensitized mice. Am J Transplant. 2011 Nov; 11(11):2322-31.
    View in: PubMed
  13. Strober S, Spitzer TR, Lowsky R, Sykes M. Translational studies in hematopoietic cell transplantation: treatment of hematologic malignancies as a stepping stone to tolerance induction. Semin Immunol. 2011 Aug; 23(4):273-81.
    View in: PubMed
  14. Farris AB, Taheri D, Kawai T, Fazlollahi L, Wong W, Tolkoff-Rubin N, Spitzer TR, Iafrate AJ, Preffer FI, Locascio SA, Sprangers B, Saidman S, Smith RN, Cosimi AB, Sykes M, Sachs DH, Colvin RB. Acute renal endothelial injury during marrow recovery in a cohort of combined kidney and bone marrow allografts. Am J Transplant. 2011 Jul; 11(7):1464-77.
    View in: PubMed
  15. Fujisaki J, Wu J, Carlson AL, Silberstein L, Putheti P, Larocca R, Gao W, Saito TI, Lo Celso C, Tsuyuzaki H, Sato T, Côté D, Sykes M, Strom TB, Scadden DT, Lin CP. In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature. 2011 Jun 9; 474(7350):216-9.
    View in: PubMed
  16. Andreola G, Chittenden M, Shaffer J, Cosimi AB, Kawai T, Cotter P, Locascio SA, Morokata T, Dey BR, Tolkoff-Rubin NT, Preffer F, Bonnefoix T, Kattleman K, Spitzer TR, Sachs DH, Sykes M. Mechanisms of donor-specific tolerance in recipients of haploidentical combined bone marrow/kidney transplantation. Am J Transplant. 2011 Jun; 11(6):1236-47.
    View in: PubMed
  17. Spitzer TR, Sykes M, Tolkoff-Rubin N, Kawai T, McAfee SL, Dey BR, Ballen K, Delmonico F, Saidman S, Sachs DH, Cosimi AB. Long-term follow-up of recipients of combined human leukocyte antigen-matched bone marrow and kidney transplantation for multiple myeloma with end-stage renal disease. Transplantation. 2011 Mar 27; 91(6):672-6.
    View in: PubMed
  18. Lucas CL, Workman CJ, Beyaz S, LoCascio S, Zhao G, Vignali DA, Sykes M. LAG-3, TGF-ß, and cell-intrinsic PD-1 inhibitory pathways contribute to CD8 but not CD4 T-cell tolerance induced by allogeneic BMT with anti-CD40L. Blood. 2011 May 19; 117(20):5532-40.
    View in: PubMed
  19. LoCascio SA, Morokata T, Chittenden M, Preffer FI, Dombkowski DM, Andreola G, Crisalli K, Kawai T, Saidman SL, Spitzer TR, Tolkoff-Rubin N, Cosimi AB, Sachs DH, Sykes M. Mixed chimerism, lymphocyte recovery, and evidence for early donor-specific unresponsiveness in patients receiving combined kidney and bone marrow transplantation to induce tolerance. Transplantation. 2010 Dec 27; 90(12):1607-15.
    View in: PubMed
  20. Hermanrud CE, Lucas CL, Sykes M, Huang CA, Wang Z. Expression and purification of soluble murine CD40L monomers and polymers in yeast Pichia pastoris. Protein Expr Purif. 2011 Mar; 76(1):115-20.
    View in: PubMed
  21. Flutter B, Edwards N, Fallah-Arani F, Henderson S, Chai JG, Sivakumaran S, Ghorashian S, Bennett CL, Freeman GJ, Sykes M, Chakraverty R. Nonhematopoietic antigen blocks memory programming of alloreactive CD8+ T cells and drives their eventual exhaustion in mouse models of bone marrow transplantation. J Clin Invest. 2010 Nov; 120(11):3855-68.
    View in: PubMed
  22. Sgroi A, Bühler LH, Morel P, Sykes M, Noel L. International human xenotransplantation inventory. Transplantation. 2010 Sep 27; 90(6):597-603.
    View in: PubMed
  23. Saito TI, Li HW, Sykes M. Invariant NKT cells are required for antitumor responses induced by host-versus-graft responses. J Immunol. 2010 Aug 15; 185(4):2099-105.
    View in: PubMed
  24. Griesemer A, Liang F, Hirakata A, Hirsh E, Lo D, Okumi M, Sykes M, Yamada K, Huang CA, Sachs DH. Occurrence of specific humoral non-responsiveness to swine antigens following administration of GalT-KO bone marrow to baboons. Xenotransplantation. 2010 Jul-Aug; 17(4):300-12.
    View in: PubMed
  25. Onoe T, Kalscheuer H, Chittenden M, Zhao G, Yang YG, Sykes M. Homeostatic expansion and phenotypic conversion of human T cells depend on peripheral interactions with APCs. J Immunol. 2010 Jun 15; 184(12):6756-65.
    View in: PubMed
  26. Saito TI, Fujisaki J, Carlson AL, Lin CP, Sykes M. Persistence of donor-derived protein in host myeloid cells after induced rejection of engrafted allogeneic bone marrow cells. Exp Hematol. 2010 Apr; 38(4):333-9.
    View in: PubMed
  27. Mollov JL, Lucas CL, Haspot F, Kurtz J, Gaspar C, Guzman A, Sykes M. Recipient dendritic cells, but not B cells, are required antigen-presenting cells for peripheral alloreactive CD8+ T-cell tolerance. Am J Transplant. 2010 Mar; 10(3):518-26.
    View in: PubMed
  28. Nikolic B, Onoe T, Takeuchi Y, Khalpey Z, Primo V, Leykin I, Smith RN, Sykes M. Distinct requirements for achievement of allotolerance versus reversal of autoimmunity via nonmyeloablative mixed chimerism induction in NOD mice. Transplantation. 2010 Jan 15; 89(1):23-32.
    View in: PubMed
  29. Sykes M. Immune evasion by chimeric trachea. N Engl J Med. 2010 Jan 14; 362(2):172-4.
    View in: PubMed
  30. Fehr T, Lucas CL, Kurtz J, Onoe T, Zhao G, Hogan T, Vallot C, Rao A, Sykes M. A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo. Blood. 2010 Feb 11; 115(6):1280-7.
    View in: PubMed
  31. Griesemer AD, Hirakata A, Shimizu A, Moran S, Tena A, Iwaki H, Ishikawa Y, Schule P, Arn JS, Robson SC, Fishman JA, Sykes M, Sachs DH, Yamada K. Results of gal-knockout porcine thymokidney xenografts. Am J Transplant. 2009 Dec; 9(12):2669-78.
    View in: PubMed
  32. Porcheray F, Wong W, Saidman SL, De Vito J, Girouard TC, Chittenden M, Shaffer J, Tolkoff-Rubin N, Dey BR, Spitzer TR, Colvin RB, Cosimi AB, Kawai T, Sachs DH, Sykes M, Zorn E. B-cell immunity in the context of T-cell tolerance after combined kidney and bone marrow transplantation in humans. Am J Transplant. 2009 Sep; 9(9):2126-35.
    View in: PubMed
  33. Cozzi E, Tallacchini M, Flanagan EB, Pierson RN, Sykes M, Vanderpool HY. The International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--chapter 1: Key ethical requirements and progress toward the definition of an international regulatory framework. Xenotransplantation. 2009 Jul-Aug; 16(4):203-14.
    View in: PubMed
  34. Habiro K, Sykes M, Yang YG. Induction of human T-cell tolerance to pig xenoantigens via thymus transplantation in mice with an established human immune system. Am J Transplant. 2009 Jun; 9(6):1324-9.
    View in: PubMed
  35. Sykes M. Mechanisms of transplantation tolerance in animals and humans. Transplantation. 2009 May 15; 87(9 Suppl):S67-9.
    View in: PubMed
  36. Brainard DM, Seung E, Frahm N, Cariappa A, Bailey CC, Hart WK, Shin HS, Brooks SF, Knight HL, Eichbaum Q, Yang YG, Sykes M, Walker BD, Freeman GJ, Pillai S, Westmoreland SV, Brander C, Luster AD, Tager AM. Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice. J Virol. 2009 Jul; 83(14):7305-21.
    View in: PubMed
  37. Sykes M. Hematopoietic cell transplantation for tolerance induction: animal models to clinical trials. Transplantation. 2009 Feb 15; 87(3):309-16.
    View in: PubMed
  38. Wang H, Asavaroengchai W, Yeap BY, Wang MG, Wang S, Sykes M, Yang YG. Paradoxical effects of IFN-gamma in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury. Blood. 2009 Apr 9; 113(15):3612-9.
    View in: PubMed
  39. Kurtz J, Raval F, Vallot C, Der J, Sykes M. CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance. Blood. 2009 Apr 9; 113(15):3475-84.
    View in: PubMed
  40. Sachs DH, Sykes M, Yamada K. Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy. Transpl Immunol. 2009 Jun; 21(2):101-5.
    View in: PubMed
  41. Fudaba Y, Onoe T, Chittenden M, Shimizu A, Shaffer JM, Bronson R, Sykes M. Abnormal regulatory and effector T cell function predispose to autoimmunity following xenogeneic thymic transplantation. J Immunol. 2008 Dec 1; 181(11):7649-59.
    View in: PubMed
  42. Chakraverty R, Flutter B, Fallah-Arani F, Eom HS, Means T, Andreola G, Schwarte S, Buchli J, Cotter P, Zhao G, Sykes M. The host environment regulates the function of CD8+ graft-versus-host-reactive effector cells. J Immunol. 2008 Nov 15; 181(10):6820-8.
    View in: PubMed
  43. Fehr T, Sykes M. Clinical experience with mixed chimerism to induce transplantation tolerance. Transpl Int. 2008 Dec; 21(12):1118-35.
    View in: PubMed
  44. Fehr T, Wang S, Haspot F, Kurtz J, Blaha P, Hogan T, Chittenden M, Wekerle T, Sykes M. Rapid deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells. J Immunol. 2008 Sep 15; 181(6):4371-80.
    View in: PubMed
  45. Haspot F, Bardwell PD, Zhao G, Sykes M. High antigen levels do not preclude B-cell tolerance induction to alpha1,3-Gal via mixed chimerism. Xenotransplantation. 2008 Sep-Oct; 15(5):313-20.
    View in: PubMed
  46. Shimizu I, Fudaba Y, Shimizu A, Yang YG, Sykes M. Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts. Transplantation. 2008 Aug 27; 86(4):601-10.
    View in: PubMed
  47. Fehr T, Haspot F, Mollov J, Chittenden M, Hogan T, Sykes M. Alloreactive CD8 T cell tolerance requires recipient B cells, dendritic cells, and MHC class II. J Immunol. 2008 Jul 1; 181(1):165-73.
    View in: PubMed
  48. Ting DT, Spitzer TR, Chaudhary A, Muzikansky A, Colby C, Power K, McAfee S, Ballen K, Attar E, Saidman SL, Preffer F, Sykes M, Dey BR. Clinical outcomes of late rather than early full-donor chimerism in patients with advanced lymphomas receiving nonmyeloablative allogeneic hematopoietic SCT. Bone Marrow Transplant. 2008 Sep; 42(5):329-35.
    View in: PubMed
  49. Camirand G, Stéphan L, Rousseau J, Sackett MK, Caron NJ, Mills P, Kurtz J, Sykes M, Rothstein DM, Tremblay JP. Central tolerance to myogenic cell transplants does not include muscle neoantigens. Transplantation. 2008 Jun 27; 85(12):1791-801.
    View in: PubMed
  50. Haspot F, Fehr T, Gibbons C, Zhao G, Hogan T, Honjo T, Freeman GJ, Sykes M. Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway. Blood. 2008 Sep 1; 112(5):2149-55.
    View in: PubMed
  51. Gibbons C, Sykes M. Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism. Immunol Rev. 2008 Jun; 223:334-60.
    View in: PubMed
  52. Ge X, Brown J, Sykes M, Boussiotis VA. CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemia-specific effectors. Biol Blood Marrow Transplant. 2008 May; 14(5):518-30.
    View in: PubMed
  53. Hering BJ, Sykes M, Sutherland DE, Shapiro AM, Tremblay JP. The first Joint Conference of the Cell Transplant Society (CTS), International Pancreas and Islet Transplant Association (IPITA), and International Xenotransplantation Association (IXA), all sections of The Transplantation Society (TTS), took place in Minneapolis, Minn, USA, from September 15-20, 2007. Preface. Transplant Proc. 2008 Mar; 40(2):335-6.
    View in: PubMed
  54. Tonomura N, Habiro K, Shimizu A, Sykes M, Yang YG. Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model. Blood. 2008 Apr 15; 111(8):4293-6.
    View in: PubMed
  55. Sykes M. 2007 IXA Presidential Address. Progress toward an ideal source animal: opportunities and challenges in a changing world. Xenotransplantation. 2008 Feb; 15(1):7-13.
    View in: PubMed
  56. Kawai T, Cosimi AB, Spitzer TR, Tolkoff-Rubin N, Suthanthiran M, Saidman SL, Shaffer J, Preffer FI, Ding R, Sharma V, Fishman JA, Dey B, Ko DS, Hertl M, Goes NB, Wong W, Williams WW, Colvin RB, Sykes M, Sachs DH. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med. 2008 Jan 24; 358(4):353-61.
    View in: PubMed
  57. Sykes M. Immune tolerance: mechanisms and application in clinical transplantation. J Intern Med. 2007 Sep; 262(3):288-310.
    View in: PubMed
  58. Hongo D, Hadidi S, Damrauer S, Garrigue V, Kraft D, Sachs DH, Nikolic B, Sykes M. Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction. J Infect Dis. 2007 Sep 15; 196(6):900-10.
    View in: PubMed
  59. Kawahara T, Rodriguez-Barbosa JI, Zhao Y, Zhao G, Sykes M. Global unresponsiveness as a mechanism of natural killer cell tolerance in mixed xenogeneic chimeras. Am J Transplant. 2007 Sep; 7(9):2090-7.
    View in: PubMed
  60. Sachs DH, Yamada K, Robson SC, Fishman JA, Shimizu A, Colvin RB, Sykes M. GalT-KO pigs: is the cup half empty or half full? Transplantation. 2007 Jul 15; 84(1):12-4.
    View in: PubMed
  61. Yang YG, Sykes M. Xenotransplantation: current status and a perspective on the future. Nat Rev Immunol. 2007 Jul; 7(7):519-31.
    View in: PubMed
  62. Shaffer J, Villard J, Means TK, Alexander S, Dombkowski D, Dey BR, McAfee S, Ballen KK, Saidman S, Preffer FI, Sachs DH, Spitzer TR, Sykes M. Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine. Exp Hematol. 2007 Jul; 35(7):1140-52.
    View in: PubMed
  63. Sykes M, Pierson RN, O'Connell P, D'Apice A, Cowan P, Cozzi E, Dorling A, Hering B, Leventhal J, Soulillou JP. Reply to 'Critics slam Russian trial to test pig pancreas for diabetes'. Nat Med. 2007 Jun; 13(6):662-3.
    View in: PubMed
  64. Sykes M. Mechanisms of tolerance induced via mixed chimerism. Front Biosci. 2007; 12:2922-34.
    View in: PubMed
  65. Dey BR, Shaffer J, Yee AJ, McAfee S, Caron M, Power K, Ting DT, Colby C, Preffer F, Ballen K, Attar E, Saidman S, Tarbell N, Sachs D, Sykes M, Spitzer TR. Comparison of outcomes after transplantation of peripheral blood stem cells versus bone marrow following an identical nonmyeloablative conditioning regimen. Bone Marrow Transplant. 2007 Jul; 40(1):19-27.
    View in: PubMed
  66. Pree I, Bigenzahn S, Fuchs D, Koporc Z, Nierlich P, Winkler C, Brandacher G, Sykes M, Muehlbacher F, Langer F, Wekerle T. CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of Indoleamine-2,3-dioxygenase. Transplantation. 2007 Mar 15; 83(5):663-7.
    View in: PubMed
  67. Ide K, Wang H, Tahara H, Liu J, Wang X, Asahara T, Sykes M, Yang YG, Ohdan H. Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5062-6.
    View in: PubMed
  68. Chakraverty R, Sykes M. The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Blood. 2007 Jul 1; 110(1):9-17.
    View in: PubMed
  69. Koyama I, Nadazdin O, Boskovic S, Ochiai T, Smith RN, Sykes M, Sogawa H, Murakami T, Strom TB, Colvin RB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft. Am J Transplant. 2007 May; 7(5):1055-61.
    View in: PubMed
  70. Papeta N, Chen T, Vianello F, Gererty L, Malik A, Mok YT, Tharp WG, Bagley J, Zhao G, Stevceva L, Yoon V, Sykes M, Sachs D, Iacomini J, Poznansky MC. Long-term survival of transplanted allogeneic cells engineered to express a T cell chemorepellent. Transplantation. 2007 Jan 27; 83(2):174-83.
    View in: PubMed
  71. Sykes M, Cozzi E, D'Apice AJ, Pierson RN, O'Connell P, Cowan P, Dorling A, Hering B, Soulillou JP, Sandrin M. Response to Valdes-Gonzalez ''Clinical trial of islet xenotransplantation in Mexico''. Xenotransplantation. 2007 Jan; 14(1):90-1.
    View in: PubMed
  72. Asavaroengchai W, Wang H, Wang S, Wang L, Bronson R, Sykes M, Yang YG. An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 2007 Jan; 13(1):46-55.
    View in: PubMed
  73. Buhler L, Sgroi A, Sykes M, Noel L. International inventory of xenotransplantation practices in humans. Xenotransplantation. 2006 Nov; 13(6):482.
    View in: PubMed
  74. Shimizu I, Kawahara T, Haspot F, Bardwell PD, Carroll MC, Sykes M. B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells. Blood. 2007 Feb 15; 109(4):1773-81.
    View in: PubMed
  75. Wang H, VerHalen J, Madariaga ML, Xiang S, Wang S, Lan P, Oldenborg PA, Sykes M, Yang YG. Attenuation of phagocytosis of xenogeneic cells by manipulating CD47. Blood. 2007 Jan 15; 109(2):836-42.
    View in: PubMed
  76. Boskovic S, Kawai T, Smith RN, Wee SL, Nadazdin O, Koyama I, Saidman S, Cardarelli F, Elias N, Sykes M, Strom T, Colvin RB, Sachs DH, Cosimi AB. Monitoring antidonor alloantibodies as a predictive assay for renal allograft tolerance/long-term observations in nonhuman primates. Transplantation. 2006 Sep 27; 82(6):819-25.
    View in: PubMed
  77. Saito TI, Rubio MT, Sykes M. Clinical relevance of recipient leukocyte infusion as antitumor therapy following nonmyeloablative allogeneic hematopoietic cell transplantation. Exp Hematol. 2006 Sep; 34(9):1271-7.
    View in: PubMed
  78. Sykes M, Cozzi E, d'Apice A, Pierson R, O'Connell P, Cowan P, Dorling A, Hering B, Leventhal J, Rees M, Sandrin M. Clinical trial of islet xenotransplantation in Mexico. Xenotransplantation. 2006 Sep; 13(5):371-2.
    View in: PubMed
  79. Chakraverty R, Côté D, Buchli J, Cotter P, Hsu R, Zhao G, Sachs T, Pitsillides CM, Bronson R, Means T, Lin C, Sykes M. An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues. J Exp Med. 2006 Aug 7; 203(8):2021-31.
    View in: PubMed
  80. Murakami M, Ito H, Harada E, Enoki T, Sykes M, Hamano K. Long-term survival of xenogeneic heart grafts achieved by costimulatory blockade and transient mixed chimerism. Transplantation. 2006 Jul 27; 82(2):275-81.
    View in: PubMed
  81. Ito H, Takeuchi Y, Shaffer J, Sykes M. Anti-CD40L monoclonal antibodies can replace anti-CD4 monoclonal antibodies for the nonmyeloablative induction of mixed xenogeneic chimerism. Transplantation. 2006 Jul 27; 82(2):251-7.
    View in: PubMed
  82. Fudaba Y, Spitzer TR, Shaffer J, Kawai T, Fehr T, Delmonico F, Preffer F, Tolkoff-Rubin N, Dey BR, Saidman SL, Kraus A, Bonnefoix T, McAfee S, Power K, Kattleman K, Colvin RB, Sachs DH, Cosimi AB, Sykes M. Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses. Am J Transplant. 2006 Sep; 6(9):2121-33.
    View in: PubMed
  83. Chakraverty R, Eom HS, Sachs J, Buchli J, Cotter P, Hsu R, Zhao G, Sykes M. Host MHC class II+ antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions. Blood. 2006 Sep 15; 108(6):2106-13.
    View in: PubMed
  84. Mapara MY, Leng C, Kim YM, Bronson R, Lokshin A, Luster A, Sykes M. Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR. Biol Blood Marrow Transplant. 2006 Jun; 12(6):623-34.
    View in: PubMed
  85. Sykes M, Cozzi E. Xenotransplantation of pig islets into Mexican children: were the fundamental ethical requirements to proceed with such a study really met? Eur J Endocrinol. 2006 Jun; 154(6):921-2; author reply 923.
    View in: PubMed
  86. Rubio MT, Zhao G, Buchli J, Chittenden M, Sykes M. Role of indirect allo- and autoreactivity in anti-tumor responses induced by recipient leukocyte infusions (RLI) in mixed chimeras prepared with nonmyeloablative conditioning. Clin Immunol. 2006 Jul; 120(1):33-44.
    View in: PubMed
  87. Xu Y, Yang YG, Ohdan H, Ryan D, Harper D, Wu C, Kruger-Grey HS, Thall AD, Awwad M, Sykes M. Characterization of anti-Gal antibody-producing cells of baboons and humans. Transplantation. 2006 Mar 27; 81(6):940-8.
    View in: PubMed
  88. Koporc Z, Bigenzahn S, Blaha P, Fariborz E, Selzer E, Sykes M, Muehlbacher F, Wekerle T. Induction of mixed chimerism through transplantation of CD45-congenic mobilized peripheral blood stem cells after nonmyeloablative irradiation. Biol Blood Marrow Transplant. 2006 Mar; 12(3):284-92.
    View in: PubMed
  89. Shimizu I, Smith NR, Zhao G, Medof E, Sykes M. Decay-accelerating factor prevents acute humoral rejection induced by low levels of anti-alphaGal natural antibodies. Transplantation. 2006 Jan 15; 81(1):95-100.
    View in: PubMed
  90. Kawai T, Sachs DH, Sykes M, Spitzer T, Tolkoff-Rubin N, Saidman S, Ko D, Dey B, Colvin RB, Cosimi AB. My most interesting cases. Clin Transpl. 2006; 580-2.
    View in: PubMed
  91. Yamamoto S, Lavelle JM, Vagefi PA, Arakawa H, Samelson-Jones E, Moran S, Teranishi K, Kamano C, Fishman J, Awwad M, Neville DM, Shimizu A, Sykes M, Sachs DH, Yamada K. Vascularized thymic lobe transplantation in a pig-to-baboon model: a novel strategy for xenogeneic tolerance induction and T-cell reconstitution. Transplantation. 2005 Dec 27; 80(12):1783-90.
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  92. Kawahara T, Shimizu I, Ohdan H, Zhao G, Sykes M. Differing mechanisms of early and late B cell hyporesponsiveness induced by mixed chimerism. Am J Transplant. 2005 Dec; 5(12):2821-9.
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  93. Eom HS, Rubio MT, Means TK, Luster AD, Sykes M. T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction. Exp Hematol. 2005 Dec; 33(12):1564-73.
    View in: PubMed
  94. Rubio MT, Means TK, Chakraverty R, Shaffer J, Fudaba Y, Chittenden M, Luster AD, Sykes M. Maturation of human monocyte-derived dendritic cells (MoDCs) in the presence of prostaglandin E2 optimizes CD4 and CD8 T cell-mediated responses to protein antigens: role of PGE2 in chemokine and cytokine expression by MoDCs. Int Immunol. 2005 Dec; 17(12):1561-72.
    View in: PubMed
  95. Fehr T, Bardwell PD, Sykes M. Use of skin grafting to demonstrate tolerance before kidney transplantation without immunosuppression in the recipient of a previous bone marrow transplant. Transplantation. 2005 Nov 15; 80(9):1359-60.
    View in: PubMed
  96. Sykes M, Spitzer TR. Protecting the host naturally. Nat Med. 2005 Nov; 11(11):1164-5.
    View in: PubMed
  97. Rodríguez-Barbosa JI, Haller GW, Zhao G, Sachs DH, Sykes M. Host thymectomy and cyclosporine lead to unstable skin graft tolerance after class I mismatched allogeneic neonatal thymic transplantation in mice. Transpl Immunol. 2005 Oct; 15(1):25-33.
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  98. Fehr T, Takeuchi Y, Kurtz J, Wekerle T, Sykes M. Early regulation of CD8 T cell alloreactivity by CD4+CD25- T cells in recipients of anti-CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor-reactive CD8+ T cells, precluding a role for sustained regulation. Eur J Immunol. 2005 Sep; 35(9):2679-90.
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  99. Blaha P, Bigenzahn S, Koporc Z, Sykes M, Muehlbacher F, Wekerle T. Short-term immunosuppression facilitates induction of mixed chimerism and tolerance after bone marrow transplantation without cytoreductive conditioning. Transplantation. 2005 Jul 27; 80(2):237-43.
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  100. Rubio MT, Saito TI, Kattleman K, Zhao G, Buchli J, Sykes M. Mechanisms of the antitumor responses and host-versus-graft reactions induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: a critical role for recipient CD4+ T cells and recipient leukocyte infusion-derived IFN-gamma-producing CD8+ T cells. J Immunol. 2005 Jul 15; 175(2):665-76.
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  101. Domenig C, Sanchez-Fueyo A, Kurtz J, Alexopoulos SP, Mariat C, Sykes M, Strom TB, Zheng XX. Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol. J Immunol. 2005 Jul 1; 175(1):51-60.
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  102. Sykes M, Nikolic B. Treatment of severe autoimmune disease by stem-cell transplantation. Nature. 2005 Jun 2; 435(7042):620-7.
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  103. Lechler RI, Sykes M, Thomson AW, Turka LA. Organ transplantation--how much of the promise has been realized? Nat Med. 2005 Jun; 11(6):605-13.
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  104. Sykes M. Commentary: World Health Assembly resolution 57.18 on xenotransplantation. Transplantation. 2005 Mar 27; 79(6):636-7.
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  105. Giovino MA, Wang H, Sykes M, Yang YG. Role of VLA-4 and VLA-5 in ex vivo maintenance of human and pig hematopoiesis in human stroma-supported long-term cultures. Exp Hematol. 2005 Mar; 33(3):363-70.
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  106. Sykes M, Shimizu I, Kawahara T. Mixed hematopoietic chimerism for the simultaneous induction of T and B cell tolerance. Transplantation. 2005 Feb 15; 79(3 Suppl):S28-9.
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  107. Dey BR, McAfee S, Colby C, Cieply K, Caron M, Saidman S, Preffer F, Shaffer J, Tarbell N, Sackstein R, Sachs D, Sykes M, Spitzer TR. Anti-tumour response despite loss of donor chimaerism in patients treated with non-myeloablative conditioning and allogeneic stem cell transplantation. Br J Haematol. 2005 Feb; 128(3):351-9.
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  108. Mapara MY, Sykes M. Induction of mixed vs full chimerism to potentiate GVL effects after bone-marrow transplantation. Methods Mol Med. 2005; 109:469-74.
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  109. Yamada K, Yazawa K, Shimizu A, Iwanaga T, Hisashi Y, Nuhn M, O'Malley P, Nobori S, Vagefi PA, Patience C, Fishman J, Cooper DK, Hawley RJ, Greenstein J, Schuurman HJ, Awwad M, Sykes M, Sachs DH. Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat Med. 2005 Jan; 11(1):32-4.
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  110. Eguchi H, Knosalla C, Lan P, Cheng J, Diouf B, Wang L, Abe M, Schuurman HJ, Sachs DH, Sykes M, Cooper DK, Yang YG. T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model. Transplantation. 2004 Dec 15; 78(11):1609-17.
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  111. Sykes M, d'Apice A, Sandrin M. Position paper of the Ethics Committee of the International Xenotransplantation Association. Transplantation. 2004 Oct 27; 78(8):1101-7.
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  112. Kurtz J, Wekerle T, Sykes M. Tolerance in mixed chimerism - a role for regulatory cells? Trends Immunol. 2004 Oct; 25(10):518-23.
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  113. Kawai T, Sogawa H, Boskovic S, Abrahamian G, Smith RN, Wee SL, Andrews D, Nadazdin O, Koyama I, Sykes M, Winn HJ, Colvin RB, Sachs DH, Cosimi AB. CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates. Am J Transplant. 2004 Sep; 4(9):1391-8.
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  114. Fehr T, Sykes M. Tolerance induction in clinical transplantation. Transpl Immunol. 2004 Sep-Oct; 13(2):117-30.
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  115. Yang YG, Wood JC, Lan P, Wilkinson RA, Sykes M, Fishman JA, Patience C. Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice. J Clin Invest. 2004 Sep; 114(5):695-700.
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  116. Sykes M, Sandrin M, Cozzi E, Rees MA. World Health Organization resolution on xenotransplantation. Xenotransplantation. 2004 May; 11(3):224-5.
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  117. Wekerle T, Sykes M. Induction of tolerance. Surgery. 2004 Apr; 135(4):359-64.
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  118. Mapara MY, Sykes M. Tolerance and cancer: mechanisms of tumor evasion and strategies for breaking tolerance. J Clin Oncol. 2004 Mar 15; 22(6):1136-51.
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  119. Kurtz J, Shaffer J, Lie A, Anosova N, Benichou G, Sykes M. Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells. Blood. 2004 Jun 1; 103(11):4336-43.
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  120. Nikolic B, Takeuchi Y, Leykin I, Fudaba Y, Smith RN, Sykes M. Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity. Diabetes. 2004 Feb; 53(2):376-83.
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  121. Sykes M, Sandrin M, Cozzi E. International cooperation on xenotransplantation. Nat Med. 2004 Feb; 10(2):119.
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  122. Lan P, Wang L, Diouf B, Eguchi H, Su H, Bronson R, Sachs DH, Sykes M, Yang YG. Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism. Blood. 2004 May 15; 103(10):3964-9.
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  123. Takeuchi Y, Ito H, Kurtz J, Wekerle T, Ho L, Sykes M. Earlier low-dose TBI or DST overcomes CD8+ T-cell-mediated alloresistance to allogeneic marrow in recipients of anti-CD40L. Am J Transplant. 2004 Jan; 4(1):31-40.
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  124. Sykes M. JAKing up immunosuppression. Nat Med. 2003 Dec; 9(12):1458-9.
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  125. Kawahara T, Ohdan H, Zhao G, Yang YG, Sykes M. Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells. J Immunol. 2003 Nov 15; 171(10):5406-14.
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  126. Ito H, Takeuchi Y, Shaffer J, Sykes M. Local irradiation enhances congenic donor pluripotent hematopoietic stem cell engraftment similarly in irradiated and nonirradiated sites. Blood. 2004 Mar 1; 103(5):1949-54.
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  127. Koenecke C, Shaffer J, Alexander SI, Preffer F, Dombkowski D, Saidman SL, Dey B, McAfee S, Spitzer TR, Sykes M. NK cell recovery, chimerism, function, and recognition in recipients of haploidentical hematopoietic cell transplantation following nonmyeloablative conditioning using a humanized anti-CD2 mAb, Medi-507. Exp Hematol. 2003 Oct; 31(10):911-23.
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  128. Kim YM, Mapara MY, Down JD, Johnson KW, Boisgerault F, Akiyama Y, Benichou G, Pelot M, Zhao G, Sykes M. Graft-versus-host-reactive donor CD4 cells can induce T cell-mediated rejection of the donor marrow in mixed allogeneic chimeras prepared with nonmyeloablative conditioning. Blood. 2004 Jan 15; 103(2):732-9.
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  129. Sykes M, Sandrin M, D'Apice A. Guidelines for xenotransplantation. N Engl J Med. 2003 Sep 25; 349(13):1294-5.
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  130. Le Guern AC, Giovino MA, Abe M, Theodore PR, Qi J, Down JD, Sachs DH, Sykes M, Yang YG. Stem cell activity of porcine c-kit+ hematopoietic cells. Exp Hematol. 2003 Sep; 31(9):833-40.
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  131. Sykes MA, Blanchard EB, Lackner J, Keefer L, Krasner S. Psychopathology in irritable bowel syndrome: support for a psychophysiological model. J Behav Med. 2003 Aug; 26(4):361-72.
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  132. Mapara MY, Kim YM, Marx J, Sykes M. Donor lymphocyte infusion-mediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: extinction of graft-versus-leukemia effects after conversion to full donor chimerism. Transplantation. 2003 Jul 27; 76(2):297-305.
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  133. Kraus AB, Shaffer J, Toh HC, Preffer F, Dombkowski D, Saidman S, Colby C, George R, McAfee S, Sackstein R, Dey B, Spitzer TR, Sykes M. Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation. Exp Hematol. 2003 Jul; 31(7):609-21.
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  134. Kurtz J, Lie A, Griffith M, Eysaman S, Shaffer J, Anosova N, Turka L, Benichou G, Sykes M. Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L. Am J Transplant. 2003 Jul; 3(7):804-16.
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  135. Zhao Y, Rodriguez-Barbosa JI, Shimizu A, Sachs DH, Sykes M. Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: evidence for failure of regulatory mechanisms suppressing autoimmunity. Transplantation. 2003 Jun 15; 75(11):1832-40.
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  136. Rubio MT, Kim YM, Sachs T, Mapara M, Zhao G, Sykes M. Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-gamma. Blood. 2003 Sep 15; 102(6):2300-7.
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  137. Zhao Y, Ohdan H, Manilay JO, Sykes M. NK cell tolerance in mixed allogeneic chimeras. J Immunol. 2003 Jun 1; 170(11):5398-405.
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  138. Daly A, McAfee S, Dey B, Colby C, Schulte L, Yeap B, Sackstein R, Tarbell NJ, Sachs D, Sykes M, Spitzer TR. Nonmyeloablative bone marrow transplantation: Infectious complications in 65 recipients of HLA-identical and mismatched transplants. Biol Blood Marrow Transplant. 2003 Jun; 9(6):373-82.
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  139. Spitzer TR, McAfee SL, Dey BR, Colby C, Hope J, Grossberg H, Preffer F, Shaffer J, Alexander SI, Sachs DH, Sykes M. Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies. Transplantation. 2003 May 27; 75(10):1748-51.
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  140. Barth RN, Yamamoto S, LaMattina JC, Kumagai N, Kitamura H, Vagefi PA, Awwad M, Colvin RB, Cooper DK, Sykes M, Sachs DH, Yamada K. Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness. Transplantation. 2003 May 27; 75(10):1615-24.
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  141. Dey BR, McAfee S, Colby C, Sackstein R, Saidman S, Tarbell N, Sachs DH, Sykes M, Spitzer TR. Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation. Biol Blood Marrow Transplant. 2003 May; 9(5):320-9.
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  142. Sykes M, d'Apice A, Sandrin M. Position paper of the Ethics Committee of the International Xenotransplantation Association. Xenotransplantation. 2003 May; 10(3):194-203.
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  143. Ohdan H, Sykes M. B cell tolerance to xenoantigens. Xenotransplantation. 2003 Mar; 10(2):98-106.
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  144. Kim YM, Sachs T, Asavaroengchai W, Bronson R, Sykes M. Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720. J Clin Invest. 2003 Mar; 111(5):659-69.
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  145. Wu A, Yamada K, Neville DM, Awwad M, Wain JC, Shimizu A, Gojo S, Kitamura H, Colvin RB, Cooper DK, Sykes M, Sachs DH. Xenogeneic thymus transplantation in a pig-to-baboon model. Transplantation. 2003 Feb 15; 75(3):282-91.
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  146. Rodriguez-Barbosa JI, Zhao Y, Houser S, Zhao G, Sykes M. Fetal porcine thymus engraftment, survival and CD4 reconstitution in alphaGal-KO mice is impaired in the presence of high levels of antibodies against alphaGal. Xenotransplantation. 2003 Jan; 10(1):24-40.
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  147. Rodriguez-Barbosa JI, Zhao Y, Zhao G, Ezquerra A, Sykes M. Murine CD4 T cells selected in a highly disparate xenogeneic porcine thymus graft do not show rapid decay in the absence of selecting MHC in the periphery. J Immunol. 2002 Dec 15; 169(12):6697-710.
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  148. Toh HC, Spitzer TR, Preffer F, Alexander SI, McAfee S, Dombkowski D, Clark JS, Colby C, Saidman S, Sackstein R, Sykes M. Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving nonmyeloablative conditioning and a haploidentical related allogeneic bone marrow transplant. Cytokines Cell Mol Ther. 2002 Dec; 7(2):43-7.
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  149. Bühler LH, Spitzer TR, Sykes M, Sachs DH, Delmonico FL, Tolkoff-Rubin N, Saidman SL, Sackstein R, McAfee S, Dey B, Colby C, Cosimi AB. Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease. Transplantation. 2002 Nov 27; 74(10):1405-9.
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  150. Blaha P, Bigenzahn S, Koporc Z, Schmid M, Langer F, Selzer E, Bergmeister H, Wrba F, Kurtz J, Kiss C, Roth E, Muehlbacher F, Sykes M, Wekerle T. The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade. Blood. 2003 Apr 1; 101(7):2886-93.
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  151. Sykes M. Transplantation. Curr Opin Immunol. 2002 Oct; 14(5):559-61.
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  152. Wekerle T, Kurtz J, Bigenzahn S, Takeuchi Y, Sykes M. Mechanisms of transplant tolerance induction using costimulatory blockade. Curr Opin Immunol. 2002 Oct; 14(5):592-600.
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  153. Lechler RI, Sykes M, Thomson AW, Turka LA. Designer meetings. Nat Immunol. 2002 Sep; 3(9):791.
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  154. Mapara MY, Kim YM, Wang SP, Bronson R, Sachs DH, Sykes M. Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells. Blood. 2002 Sep 1; 100(5):1903-9.
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  155. Theodore PR, Simon AR, Warrens AN, Sackstein R, Sykes M. Porcine mononuclear cells adhere to human fibronectin independently of very late antigen-5: implications for donor-specific tolerance induction in xenotransplantation. Xenotransplantation. 2002 Jul; 9(4):277-89.
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  156. Heinz M, Huang CA, Emery DW, Giovino MA, LeGuern A, Kurilla-Mahon B, Theodore P, Arn JS, Sykes M, Mulligan R, Down JD, Sachs DH, Goodell MA. Use of CD9 expression to enrich for porcine hematopoietic progenitors. Exp Hematol. 2002 Jul; 30(7):809-15.
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  157. Yang YG, Qi J, Wang MG, Sykes M. Donor-derived interferon gamma separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells. Blood. 2002 Jun 1; 99(11):4207-15.
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  158. Abe M, Qi J, Sykes M, Yang YG. Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier. Blood. 2002 May 15; 99(10):3823-9.
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  159. Wekerle T, Nikolic B, Pearson DA, Swenson KG, Sykes M. Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high-dose bone marrow transplantation for the induction of mixed chimerism and tolerance. Transpl Int. 2002 May; 15(5):248-53.
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  160. Giovino MA, Down JD, Jackson JD, Sykes M, Monroy RL, White-Scharf ME. Porcine hematopoiesis on primate stroma in long-term cultures: enhanced growth with neutralizing tumor necrosis factor-alpha and tumor growth factor-beta antibodies. Transplantation. 2002 Mar 15; 73(5):723-31.
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  161. Bühler L, Awwad M, Treter S, Chang Q, Basker M, Alwayn IP, Teranishi K, Ericsson T, Moran K, Harper D, Kurilla-Mahon B, Huang CA, Sackstein R, Sykes M, White-Scharf ME, Sachs DH, Down JD, Cooper DK. Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade. Transplantation. 2002 Jan 15; 73(1):12-22.
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  162. Abe M, Cheng J, Qi J, Glaser RM, Thall AD, Sykes M, Yang YG. Elimination of porcine hemopoietic cells by macrophages in mice. J Immunol. 2002 Jan 15; 168(2):621-8.
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  163. Preffer FI, Dombkowski D, Sykes M, Scadden D, Yang YG. Lineage-negative side-population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization. Stem Cells. 2002; 20(5):417-27.
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  164. Sykes M, Spitzer TR. Non-myeloblative induction of mixed hematopoietic chimerism: application to transplantation tolerance and hematologic malignancies in experimental and clinical studies. Cancer Treat Res. 2002; 110:79-99.
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  165. Zhao Y, Rodriguez-Barbosa JI, Swenson K, Zhao G, Arn JS, Sykes M. Highly disparate xenogeneic skin graft tolerance induction by fetal pig thymus in thymectomized mice: Conditioning requirements and the role of coimplantation of fetal pig liver. Transplantation. 2001 Nov 27; 72(10):1608-15.
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  166. Russell PS, Chase CM, Sykes M, Ito H, Shaffer J, Colvin RB. Tolerance, mixed chimerism, and chronic transplant arteriopathy. J Immunol. 2001 Nov 15; 167(10):5731-40.
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  167. Ohdan H, Swenson KG, Kitamura H, Yang YG, Sykes M. Tolerization of Gal alpha 1,3Gal-reactive B cells in pre-sensitized alpha 1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism. Xenotransplantation. 2001 Nov; 8(4):227-38.
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  168. Kurtz J, Ito H, Wekerle T, Shaffer J, Sykes M. Mechanisms involved in the establishment of tolerance through costimulatory blockade and BMT: lack of requirement for CD40L-mediated signaling for tolerance or deletion of donor-reactive CD4+ cells. Am J Transplant. 2001 Nov; 1(4):339-49.
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  169. Rodriguez-Barbosa JI, Zhao Y, Barth R, Zhao G, Arn JS, Sachs DH, Sykes M. Enhanced CD4 reconstitution by grafting neonatal porcine tissue in alternative locations is associated with donor-specific tolerance and suppression of preexisting xenoreactive T cells. Transplantation. 2001 Oct 15; 72(7):1223-31.
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  170. Kawai T, Sogawa H, Koulmanda M, Smith RN, O'Neil JJ, Wee SL, Boskovic S, Sykes M, Colvin RB, Sachs DH, Auchincloss H, Cosimi AB, C Ko DS. Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor. Transplantation. 2001 Jul 27; 72(2):351-4.
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  171. Ohdan H, Yang YG, Swenson KG, Kitamura H, Sykes M. T cell and B cell tolerance to GALalpha1,3GAL-expressing heart xenografts is achieved in alpha1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism. Transplantation. 2001 Jun 15; 71(11):1532-42.
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  172. Sykes M, Sachs DH. Mixed chimerism. Philos Trans R Soc Lond B Biol Sci. 2001 May 29; 356(1409):707-26.
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  173. Sykes M. Mixed chimerism and transplant tolerance. Immunity. 2001 Apr; 14(4):417-24.
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  174. Ito H, Kurtz J, Shaffer J, Sykes M. CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway. J Immunol. 2001 Mar 1; 166(5):2970-81.
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  175. Sykes M. Graft-versus-host alloresponses to treat nonlymphohematopoietic tumors: is there a solid approach? J Immunother. 2001 Mar-Apr; 24(2):101-3.
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  176. Wekerle T, Kurtz J, Sayegh M, Ito H, Wells A, Bensinger S, Shaffer J, Turka L, Sykes M. Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death. J Immunol. 2001 Feb 15; 166(4):2311-6.
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  177. Leykin I, Nikolic B, Sykes M. Mixed bone marrow chimerism as a treatment for autoimmune diabetes. Transplant Proc. 2001 Feb-Mar; 33(1-2):120.
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  178. Zhao Y, Rodriguez-Barbosa JI, Zhao G, Shaffer J, Arn JS, Sykes M. Maturation and function of mouse T-cells with a transgenic TCR positively selected by highly disparate xenogeneic porcine MHC. Cell Mol Biol (Noisy-le-grand). 2001 Feb; 47(1):217-28.
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  179. Wu A, Yamada K, Awwad M, Kitamura H, Wain J, Neville DM, Cooper DK, Sykes M, Sachs DH. Effects of xenogeneic thymic transplantation in baboons. Transplant Proc. 2001 Feb-Mar; 33(1-2):766.
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  180. Nikolic B, Zhao G, Sykes M. A role for donor-derived B cells but not T cells in the maintenance of mixed hematopoietic chimerism. Transplant Proc. 2001 Feb-Mar; 33(1-2):182.
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  181. Nikolic B, Cooke DT, Zhao G, Sykes M. Both gamma delta T cells and NK cells inhibit the engraftment of xenogeneic rat bone marrow cells and the induction of xenograft tolerance in mice. J Immunol. 2001 Jan 15; 166(2):1398-404.
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  182. Spitzer TR, Sykes M. Treatment of renal-cell cancer by transplantation of allogeneic stem cells. N Engl J Med. 2001 Jan 11; 344(2):137-8.
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  183. Mapara MY, Pelot M, Zhao G, Swenson K, Pearson D, Sykes M. Induction of stable long-term mixed hematopoietic chimerism following nonmyeloablative conditioning with T cell-depleting antibodies, cyclophosphamide, and thymic irradiation leads to donor-specific in vitro and in vivo tolerance. Biol Blood Marrow Transplant. 2001; 7(12):646-55.
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  184. Nikolic B, Khan A, Sykes M. Induction of tolerance by mixed chimerism with nonmyeloblative host conditioning: the importance of overcoming intrathymic alloresistance. Biol Blood Marrow Transplant. 2001; 7(3):144-53.
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  185. Wekerle T, Sykes M. Mixed chimerism and transplantation tolerance. Annu Rev Med. 2001; 52:353-70.
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  186. Dey BR, McAfee S, Sackstein R, Colby C, Saidman S, Weymouth D, Poliquin C, Vanderklish J, Sachs DH, Sykes M, Spitzer TR. Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation. Biol Blood Marrow Transplant. 2001; 7(11):604-12.
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  187. Sachs DH, Sykes M, Robson SC, Cooper DK. Xenotransplantation. Adv Immunol. 2001; 79:129-223.
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  188. Ohdan H, Swenson KG, Kruger Gray HS, Yang YG, Xu Y, Thall AD, Sykes M. Mac-1-negative B-1b phenotype of natural antibody-producing cells, including those responding to Gal alpha 1,3Gal epitopes in alpha 1,3-galactosyltransferase-deficient mice. J Immunol. 2000 Nov 15; 165(10):5518-29.
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  189. Wu A, Yamada K, Awwad M, Shimizu A, Watts A, Murphy M, Gojo S, Neville D, Cooper DK, Sykes M, Sachs DH. Experience with porcine thymic transplantation in baboons. Transplant Proc. 2000 Aug; 32(5):1048.
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  190. Abe M, Chen AM, Qi J, Sachs DH, Sykes M, Yang Y. Porcine stem cell factor facilitates long-lasting porcine hematopoietic engraftment in murine recipients. Transplant Proc. 2000 Aug; 32(5):1047.
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  191. Bühler L, Awwad M, Basker M, Gojo S, Thall A, Down JD, Sykes M, Andrews D, Sackstein R, White-Scharf ME, Sachs DH, Cooper DK. A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons. Transplant Proc. 2000 Aug; 32(5):1100.
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  192. Nikolic B, Zhao G, Swenson K, Sykes M. A novel application of cyclosporine A in nonmyeloablative pretransplant host conditioning for allogeneic BMT. Blood. 2000 Aug 1; 96(3):1166-72.
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  193. Chen AM, Zhou Y, Swenson K, Sachs DH, Sykes M, Yang YG. Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers. Transplantation. 2000 Jun 27; 69(12):2484-90.
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  194. Bühler L, Awwad M, Basker M, Gojo S, Watts A, Treter S, Nash K, Oravec G, Chang Q, Thall A, Down JD, Sykes M, Andrews D, Sackstein R, White-Scharf ME, Sachs DH, Cooper DK. High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation. 2000 Jun 15; 69(11):2296-304.
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  195. Fuchimoto Y, Huang CA, Yamada K, Shimizu A, Kitamura H, Colvin RB, Ferrara V, Murphy MC, Sykes M, White-Scharf M, Neville DM, Sachs DH. Mixed chimerism and tolerance without whole body irradiation in a large animal model. J Clin Invest. 2000 Jun; 105(12):1779-89.
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  196. Zhao Y, Swenson K, Wekerle T, Rodriguez-Barbosa JI, Arn JS, Sykes M. The critical role of mouse CD4+ cells in the rejection of highly disparate xenogeneic pig thymus grafts. Xenotransplantation. 2000 May; 7(2):129-37.
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  197. Nikolic B, Lee S, Bronson RT, Grusby MJ, Sykes M. Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets. J Clin Invest. 2000 May; 105(9):1289-98.
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  198. Zhao Y, Rodriguez-Barbosa JI, Swenson K, Barth RN, Shimizu A, Arn JS, Sachs DH, Sykes M. The induction of specific pig skin graft tolerance by grafting with neonatal pig thymus in thymectomized mice. Transplantation. 2000 Apr 15; 69(7):1447-51.
    View in: PubMed
  199. Wekerle T, Kurtz J, Ito H, Ronquillo JV, Dong V, Zhao G, Shaffer J, Sayegh MH, Sykes M. Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment. Nat Med. 2000 Apr; 6(4):464-9.
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  200. Ohdan H, Yang YG, Swenson KG, Thall AD, Sykes M. In vivo T-cell depletion enhances production of anti-GALalpha1,3GAL natural antibodies in alpha1,3-galactosyltransferase-deficient mice. Transplantation. 2000 Mar 15; 69(5):910-3.
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  201. Cheng T, Rodrigues N, Shen H, Yang Y, Dombkowski D, Sykes M, Scadden DT. Hematopoietic stem cell quiescence maintained by p21cip1/waf1. Science. 2000 Mar 10; 287(5459):1804-8.
    View in: PubMed
  202. Warrens AN, Simon AR, Theodore PR, Sachs DH, Sykes M. Cross-species compatibility of intercellular adhesion molecule-1 (CD54) with its ligands. Transplantation. 2000 Feb 15; 69(3):394-9.
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  203. Yang YG, Chen AM, Garrett LJ, Sergio JJ, Theodore P, Awwad M, VerHalen J, Bodine DM, Sachs DH, Sykes M. Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier. Xenotransplantation. 2000 Feb; 7(1):58-64.
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  204. Yang YG, Chen AM, Sergio JJ, Zhou Y, Sykes M. Role of antibody-independent complement activation in rejection of porcine bone marrow cells in mice. Transplantation. 2000 Jan 15; 69(1):163-5.
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  205. Spitzer TR, McAfee S, Sackstein R, Colby C, Toh HC, Multani P, Saidman S, Weyouth DW, Preffer F, Poliquin C, Foley A, Cox B, Andrews D, Sachs DH, Sykes M. Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies. Biol Blood Marrow Transplant. 2000; 6(3A):309-20.
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  206. Kozlowski T, Sablinski T, Basker M, Kitamura H, Spitzer TR, Fishman J, Sykes M, Cooper DK, Sachs DH. Decreased graft-versus-host disease after haplotype mismatched bone marrow allografts in miniature swine following interleukin-2 treatment. Bone Marrow Transplant. 2000 Jan; 25(1):47-52.
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  207. Wekerle T, Sayegh MH, Ito H, Hill J, Chandraker A, Pearson DA, Swenson KG, Zhao G, Sykes M. Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance. Transplantation. 1999 Nov 15; 68(9):1348-55.
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  208. Haller GW, Esnaola N, Yamada K, Wu A, Shimizu A, Hansen A, Ferrara VR, Allison KS, Colvin RB, Sykes M, Sachs DH. Thymic transplantation across an MHC class I barrier in swine. J Immunol. 1999 Oct 1; 163(7):3785-92.
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  209. Manilay JO, Waneck GL, Sykes M. Levels of Ly-49 receptor expression are determined by the frequency of interactions with MHC ligands: evidence against receptor calibration to a "useful" level. J Immunol. 1999 Sep 1; 163(5):2628-33.
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  210. Wekerle T, Sykes M. Mixed chimerism as an approach for the induction of transplantation tolerance. Transplantation. 1999 Aug 27; 68(4):459-67.
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  211. Spitzer TR, Delmonico F, Tolkoff-Rubin N, McAfee S, Sackstein R, Saidman S, Colby C, Sykes M, Sachs DH, Cosimi AB. Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation. 1999 Aug 27; 68(4):480-4.
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  212. Ohdan H, Yang YG, Shimizu A, Swenson KG, Sykes M. Mixed chimerism induced without lethal conditioning prevents T cell- and anti-Gal alpha 1,3Gal-mediated graft rejection. J Clin Invest. 1999 Aug; 104(3):281-90.
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  213. Dey B, Yang YG, Preffer F, Shimizu A, Swenson K, Dombkowski D, Sykes M. The fate of donor T-cell receptor transgenic T cells with known host antigen specificity in a graft-versus-host disease model. Transplantation. 1999 Jul 15; 68(1):141-9.
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  214. Simon AR, Warrens AN, Sykes M. Efficacy of adhesive interactions in pig-to-human xenotransplantation. Immunol Today. 1999 Jul; 20(7):323-30.
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  215. Sykes M, Preffer F, McAfee S, Saidman SL, Weymouth D, Andrews DM, Colby C, Sackstein R, Sachs DH, Spitzer TR. Mixed lymphohaemopoietic chimerism and graft-versus-lymphoma effects after non-myeloablative therapy and HLA-mismatched bone-marrow transplantation. Lancet. 1999 May 22; 353(9166):1755-9.
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  216. Yang YG, Sykes M. The role of interleukin-12 in preserving the graft-versus-leukemia effect of allogeneic CD8 T cells independently of GVHD. Leuk Lymphoma. 1999 May; 33(5-6):409-20.
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  217. Warrens AN, Simon AR, Theodore PR, Sykes M. Human-porcine receptor-ligand compatibility within the immune system: relevance for xenotransplantation. Xenotransplantation. 1999 May; 6(2):75-8.
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  218. Nikolic B, Gardner JP, Scadden DT, Arn JS, Sachs DH, Sykes M. Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC. J Immunol. 1999 Mar 15; 162(6):3402-7.
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  219. Ohdan H, Yang YG, Sykes M. Reduction of anti-Gal alpha 1-3Gal natural antibodies in sera of alpha 1,3-galactosyltransferase-deficient mice receiving Gal-positive bone marrow transplantation. Transplant Proc. 1999 Feb-Mar; 31(1-2):945-6.
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  220. Nikolic B, Sykes M. Porcine thymus supports development of human T cells that are tolerant to porcine xenoantigens. Transplant Proc. 1999 Feb-Mar; 31(1-2):924.
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  221. Wu A, Esnaola NF, Yamada K, Awwad M, Shimizu A, Huang C, Wain J, Zhao Y, Neville DM, Cooper DK, Sykes M, Sachs DH. Xenogeneic thymic transplantation in a pig-to-nonhuman primate model. Transplant Proc. 1999 Feb-Mar; 31(1-2):957.
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  222. Cooke DT, Nikolic B, Sykes M. The role of atypical T cells and NK cells in inhibiting primary engraftment of xenogeneic donor rat bone marrow cells. Transplant Proc. 1999 Feb-Mar; 31(1-2):683.
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  223. Wekerle T, Sayegh MH, Chandraker A, Swenson KG, Zhao Y, Sykes M. Role of peripheral clonal deletion in tolerance induction with bone marrow transplantation and costimulatory blockade. Transplant Proc. 1999 Feb-Mar; 31(1-2):680.
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  224. Sykes M, Pearson DA, Taylor PA, Szot GL, Goldman SJ, Blazar BR. Dose and timing of interleukin (IL)-12 and timing and type of total-body irradiation: effects on graft-vs.-host disease inhibition and toxicity of exogenous IL-12 in murine bone marrow transplant recipients. Biol Blood Marrow Transplant. 1999; 5(5):277-84.
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  225. Pelot MR, Pearson DA, Swenson K, Zhao G, Sachs J, Yang YG, Sykes M. Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based nonmyeloablative conditioning regimen. Biol Blood Marrow Transplant. 1999; 5(3):133-43.
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  226. Yang YG, Dey BR, Sergio JJ, Pearson DA, Sykes M. Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12. J Clin Invest. 1998 Dec 15; 102(12):2126-35.
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  227. Manilay JO, Waneck GL, Sykes M. Altered expression of Ly-49 receptors on NK cells developing in mixed allogeneic bone marrow chimeras. Int Immunol. 1998 Dec; 10(12):1943-55.
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  228. Sykes M, Ohdan H, Manilay JO, Wekerle T, Yang YG. Hematopoietic chimerism and tolerance of T cells, B cells, and NK cells. Transplant Proc. 1998 Dec; 30(8):4020.
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  229. Manilay JO, Sykes M. Natural killer cells and their role in graft rejection. Curr Opin Immunol. 1998 Oct; 10(5):532-8.
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  230. Wekerle T, Sachs DH, Sykes M. Mixed chimerism for the induction of tolerance: potential applicability in clinical composite tissue grafting. Transplant Proc. 1998 Sep; 30(6):2708-10.
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  231. Dey B, Sykes M, Spitzer TR. Outcomes of recipients of both bone marrow and solid organ transplants. A review. Medicine (Baltimore). 1998 Sep; 77(5):355-69.
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  232. Simon AR, Warrens AN, Yazzie NP, Seebach JD, Sachs DH, Sykes M. Cross-species interaction of porcine and human integrins with their respective ligands: implications for xenogeneic tolerance induction. Transplantation. 1998 Aug 15; 66(3):385-94.
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  233. Zhao Y, Swenson K, Sergio JJ, Sykes M. Pig MHC mediates positive selection of mouse CD4+ T cells with a mouse MHC-restricted TCR in pig thymus grafts. J Immunol. 1998 Aug 1; 161(3):1320-6.
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  234. Warrens AN, Simon AR, Theodore PR, Sachs DH, Sykes M. Function of porcine adhesion molecules in a human marrow microenvironment. Transplantation. 1998 Jul 27; 66(2):252-9.
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  235. Manilay JO, Pearson DA, Sergio JJ, Swenson KG, Sykes M. Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regimen. Transplantation. 1998 Jul 15; 66(1):96-102.
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  236. Yang YG, deGoma E, Barth R, Sergio JJ, Sykes M. B-cell reconstitution and xenoreactive anti-pig natural antibody production in severe combined immunodeficient mice reconstituted with immunocompetent B cells from varying sources. Transplantation. 1998 Jul 15; 66(1):89-95.
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  237. Wekerle T, Sayegh MH, Hill J, Zhao Y, Chandraker A, Swenson KG, Zhao G, Sykes M. Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance. J Exp Med. 1998 Jun 15; 187(12):2037-44.
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  238. Sykes M, Szot GL, Swenson K, Pearson DA, Wekerle T. Separate regulation of peripheral hematopoietic and thymic engraftment. Exp Hematol. 1998 Jun; 26(6):457-65.
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  239. Nikolic B, Lei H, Pearson DA, Sergio JJ, Swenson KG, Sykes M. Role of intrathymic rat class II+ cells in maintaining deletional tolerance in xenogeneic rat-->mouse bone marrow chimeras. Transplantation. 1998 May 15; 65(9):1216-24.
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  240. Dey BR, Yang YG, Szot GL, Pearson DA, Sykes M. Interleukin-12 inhibits graft-versus-host disease through an Fas-mediated mechanism associated with alterations in donor T-cell activation and expansion. Blood. 1998 May 1; 91(9):3315-22.
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  241. Yang YG, deGoma E, Ohdan H, Bracy JL, Xu Y, Iacomini J, Thall AD, Sykes M. Tolerization of anti-Galalpha1-3Gal natural antibody-forming B cells by induction of mixed chimerism. J Exp Med. 1998 Apr 20; 187(8):1335-42.
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  242. Sachs DH, Colvin RB, Cosimi AB, Russell PS, Sykes M, McGregor CG, Platt JL. Xenotransplantation--caution, but no moratorium. Nat Med. 1998 Apr; 4(4):372-3.
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  243. Zhao Y, Barth RN, Swenson K, Pearson DA, Sykes M. Functionally and phenotypically mature mouse CD8+ T cells develop in porcine thymus grafts in mice. Xenotransplantation. 1998 Feb; 5(1):99-104.
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  244. Colby C, Sykes M, Sachs DH, Spitzer TR. Cellular modulation of acute graft-vs.-host disease. Biol Blood Marrow Transplant. 1997 Dec; 3(6):287-93.
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  245. Yang YG, Sergio JJ, Pearson DA, Szot GL, Shimizu A, Sykes M. Interleukin-12 preserves the graft-versus-leukemia effect of allogeneic CD8 T cells while inhibiting CD4-dependent graft-versus-host disease in mice. Blood. 1997 Dec 1; 90(11):4651-60.
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  246. Yang YG, Dey B, Sergio JJ, Sykes M. Interleukin-12 prevents severe acute graft-versus-host disease (GVHD) and GVHD-associated immune dysfunction in a fully major histocompatibility complex haplotype-mismatched murine bone marrow transplantation model. Transplantation. 1997 Nov 15; 64(9):1343-52.
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  247. Sykes M, Zhao Y, Yang YG. Tolerance induction for xenotransplantation. World J Surg. 1997 Nov-Dec; 21(9):932-8.
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  248. Nikolic B, Sykes M. Bone marrow chimerism and transplantation tolerance. Curr Opin Immunol. 1997 Oct; 9(5):634-40.
    View in: PubMed
  249. Zhao Y, Sergio JJ, Swenson K, Arn JS, Sachs DH, Sykes M. Positive and negative selection of functional mouse CD4 cells by porcine MHC in pig thymus grafts. J Immunol. 1997 Sep 1; 159(5):2100-7.
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  250. Zhao Y, Sykes M. Resistance to monoclonal antibody-induced CD8+ T-cell depletion in thymectomized MHC class II-deficient mice. Transplantation. 1997 Aug 15; 64(3):489-94.
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  251. Sykes M, Szot GL, Swenson KA, Pearson DA. Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning. Nat Med. 1997 Jul; 3(7):783-7.
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  252. Mayfield RS, Hayashi H, Sawada T, Bergen K, LeGuern C, Sykes M, Sachs DH, Iacomini J. The mechanism of specific prolongation of class I-mismatched skin grafts induced by retroviral gene therapy. Eur J Immunol. 1997 May; 27(5):1177-81.
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  253. Zhao Y, Fishman JA, Sergio JJ, Oliveros JL, Pearson DA, Szot GL, Wilkinson RA, Arn JS, Sachs DH, Sykes M. Immune restoration by fetal pig thymus grafts in T cell-depleted, thymectomized mice. J Immunol. 1997 Feb 15; 158(4):1641-9.
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  254. Hayashi H, Mayfield RS, Sawada T, Germana S, Sykes M, Iacomini J, Sachs DH, LeGuern C. Role of the thymus in donor specific hyporesponsiveness induced by retroviral transduction of bone marrow using an MHC class I gene. Transplant Proc. 1997 Feb-Mar; 29(1-2):1133.
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  255. Yasumoto A, Yamada K, Sablinski T, LeGuern C, Sykes M, Sachs DH. Mechanism of tolerance following class II gene transduction of autologous swine bone marrow. Transplant Proc. 1997 Feb-Mar; 29(1-2):1132.
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  256. Zhao Y, Sergio JJ, Pearson DA, Szot GL, Arn JS, Sachs DH, Sykes M. Repopulation of mouse CD4 cells in BALB/c nude mice receiving fetal pig thymus/liver grafts. Transplant Proc. 1997 Feb-Mar; 29(1-2):1228-9.
    View in: PubMed
  257. Khan A, Sergio JJ, Zhao Y, Pearson DA, Sachs DH, Sykes M. Discordant xenogeneic neonatal thymic transplantation can induce donor-specific tolerance. Transplantation. 1997 Jan 15; 63(1):124-31.
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  258. Nikolic B, Sykes M. Mixed hematopoietic chimerism and transplantation tolerance. Immunol Res. 1997; 16(3):217-28.
    View in: PubMed
  259. Nikolic B, Sykes M. Clonal deletion as a mechanism of transplantation tolerance. J Heart Lung Transplant. 1996 Dec; 15(12):1171-8.
    View in: PubMed
  260. Zhao Y, Swenson K, Sergio JJ, Arn JS, Sachs DH, Sykes M. Skin graft tolerance across a discordant xenogeneic barrier. Nat Med. 1996 Nov; 2(11):1211-6.
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  261. Sykes M. Chimerism and central tolerance. Curr Opin Immunol. 1996 Oct; 8(5):694-703.
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  262. Khan A, Tomita Y, Sykes M. Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance. Transplantation. 1996 Aug 15; 62(3):380-7.
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  263. Hayashi H, LeGuern C, Sachs DH, Sykes M. Alloresistance to K locus class I-mismatched bone marrow engraftment is mediated entirely by CD4+ and CD8+ T cells. Bone Marrow Transplant. 1996 Aug; 18(2):285-92.
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  264. Sykes M. Hematopoietic cell transplantation for the induction of allo- and xenotolerance. Clin Transplant. 1996 Aug; 10(4):357-63.
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  265. Sykes M. Immunobiology of transplantation. FASEB J. 1996 May; 10(7):721-30.
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  266. Gritsch HA, Sykes M. Hematopoietic competition limits xenogenic myeloid reconstitution in SCID mice. Transplant Proc. 1996 Apr; 28(2):708.
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  267. Yang YG, Glaser RM, Monroy R, Swenson K, Sykes M. Enhanced porcine hematopoiesis in mice receiving donor-specific interleukin-3. Transplant Proc. 1996 Apr; 28(2):655.
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  268. Hayashi H, LeGuern C, Sachs DH, Sykes M. Long-term engraftment of precultured post-5-fluorouracil allogeneic marrow in mice conditioned with a nonmyeloablative regimen: relevance for a gene therapy approach to tolerance induction. Transpl Immunol. 1996 Mar; 4(1):86-90.
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  269. Tomita Y, Sachs DH, Khan A, Sykes M. Additional monoclonal antibody (mAB) injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation. Transplantation. 1996 Feb 15; 61(3):469-77.
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  270. Tomita Y, Khan A, Sykes M. Mechanism by which additional monoclonal antibody (mAB) injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation. Transplantation. 1996 Feb 15; 61(3):477-85.
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  271. Lee LA, Sergio JJ, Sykes M. Natural killer cells weakly resist engraftment of allogeneic, long-term, multilineage-repopulating hematopoietic stem cells. Transplantation. 1996 Jan 15; 61(1):125-32.
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  272. Szebeni J, Sykes M. CAG repeat mutation in the mouse IL-2 gene enables concurrent assessment of T- and B-cell-specific gene expression by northern analysis. Exp Clin Immunogenet. 1996; 13(2):117-9.
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  273. Wang MG, Szebeni J, Pearson DA, Szot GL, Sykes M. Inhibition of graft-versus-host disease by interleukin-2 treatment is associated with altered cytokine production by expanded graft-versus-host-reactive CD4+ helper cells. Transplantation. 1995 Sep 15; 60(5):481-90.
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  274. Sykes M, Szot GL, Nguyen PL, Pearson DA. Interleukin-12 inhibits murine graft-versus-host disease. Blood. 1995 Sep 15; 86(6):2429-38.
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  275. Sachs DH, Sykes M, Greenstein JL, Cosimi AB. Tolerance and xenograft survival. Nat Med. 1995 Sep; 1(9):969.
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  276. Sykes M, Pearson DA, Szot GL. IL-2-induced GVHD protection is not inhibited by cyclosporine and is maximal when IL-2 is given over a 25 h period beginning on the day following bone marrow transplantation. Bone Marrow Transplant. 1995 Mar; 15(3):395-9.
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  277. Fraser CC, Sykes M, Lee RS, Sachs DH, LeGuern C. Specific unresponsiveness to a retrovirally-transferred class I antigen is controlled through the helper pathway. J Immunol. 1995 Feb 15; 154(4):1587-95.
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  278. Hayashi H, Lee RS, Germana S, Fraser C, Sykes M, Sachs DH, LeGuern C. Retroviral vectors for long-term expression of allogeneic major histocompatibility complex transduced into syngeneic bone marrow cells. Transplant Proc. 1995 Feb; 27(1):178-9.
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  279. Kawai T, Cosimi AB, Colvin RB, Powelson J, Eason J, Kozlowski T, Sykes M, Monroy R, Tanaka M, Sachs DH. Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys. Transplantation. 1995 Jan 27; 59(2):256-62.
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  280. Szebeni J, Wang MG, Pearson DA, Szot GL, Sykes M. IL-2 inhibits early increases in serum gamma interferon levels associated with graft-versus-host-disease. Transplantation. 1994 Dec 27; 58(12):1385-93.
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  281. Lee LA, Gritsch HA, Sergio JJ, Arn JS, Glaser RM, Sablinski T, Sachs DH, Sykes M. Specific tolerance across a discordant xenogeneic transplantation barrier. Proc Natl Acad Sci U S A. 1994 Nov 8; 91(23):10864-7.
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  282. Sykes M, Lee LA, Sachs DH. Xenograft tolerance. Immunol Rev. 1994 Oct; 141:245-76.
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  283. Tomita Y, Khan A, Sykes M. Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen. J Immunol. 1994 Aug 1; 153(3):1087-98.
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  284. Tanaka M, Latinne D, Gianello P, Sablinski T, Lorf T, Bailin M, Nickeleit V, Colvin R, Lebowitz E, Sykes M, et al. Xenotransplantation from pig to cynomolgus monkey: the potential for overcoming xenograft rejection through induction of chimerism. Transplant Proc. 1994 Jun; 26(3):1326-7.
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  285. Emery DW, Sykes M, Sachs DH, LeGuern C. Mixed swine/human long-term bone marrow cultures. Transplant Proc. 1994 Jun; 26(3):1313-4.
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  286. Lee LA, Sergio JJ, Sachs DH, Sykes M. Mechanism of tolerance in mixed xenogeneic chimeras prepared with a nonmyeloablative conditioning regimen. Transplant Proc. 1994 Jun; 26(3):1197-8.
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  287. Lee LA, Gritsch HA, Arn JS, Emery DW, Glaser RM, Sablinski T, Sachs DH, Sykes M. Induction of tolerance to pig antigens in mice grafted with fetal pig thymus/liver grafts. Transplant Proc. 1994 Jun; 26(3):1300-1.
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  288. Sykes M, Harty MW, Szot GL, Pearson DA. Interleukin-2 inhibits graft-versus-host disease-promoting activity of CD4+ cells while preserving CD4- and CD8-mediated graft-versus-leukemia effects. Blood. 1994 May 1; 83(9):2560-9.
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  289. Gritsch HA, Glaser RM, Emery DW, Lee LA, Smith CV, Sablinski T, Arn JS, Sachs DH, Sykes M. The importance of nonimmune factors in reconstitution by discordant xenogeneic hematopoietic cells. Transplantation. 1994 Mar 27; 57(6):906-17.
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  290. Tomita Y, Sachs DH, Sykes M. Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow. Blood. 1994 Feb 15; 83(4):939-48.
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  291. Sykes M, Harty MW, Pearson DA. Strain dependence of interleukin-2-induced graft-versus-host disease protection: evidence that interleukin-2 inhibits selected CD4 functions. J Immunother Emphasis Tumor Immunol. 1994 Jan; 15(1):11-21.
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  292. Latinne D, Vitiello DM, Sachs DH, Sykes M. Tolerance to discordant xenografts. I. Sharing of human natural antibody determinants on miniature swine bone marrow cells and endothelial cells. Transplantation. 1994 Jan; 57(2):238-45.
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  293. Sykes M. Novel approaches to the control of graft versus host disease. Curr Opin Immunol. 1993 Oct; 5(5):774-81.
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  294. Sykes M, Harty MW, Karlhofer FM, Pearson DA, Szot G, Yokoyama W. Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation. J Exp Med. 1993 Jul 1; 178(1):223-9.
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  295. Sachs DH, Smith CV, Emery DW, LeGuern C, Bodine D, Nienhuis A, Sykes M. Induction of specific tolerance to MHC-disparate allografts through genetic engineering. Exp Nephrol. 1993 Mar-Apr; 1(2):128-33.
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  296. Sykes M, Abraham VS, Harty MW, Pearson DA. Selective inhibition of CD4 graft-versus-host activity in IL-2-treated mice. Transplant Proc. 1993 Feb; 25(1 Pt 2):1225-6.
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  297. Lee LA, Sachs DH, Sykes M. Effect of natural killer cell depletion on long-term multilineage allogeneic bone marrow engraftment. Transplant Proc. 1993 Feb; 25(1 Pt 2):1246-7.
    View in: PubMed
  298. Latinne D, Gianello P, Smith CV, Nickeleit V, Kawai T, Beadle M, Haug C, Sykes M, Lebowitz E, Bazin H, et al. Xenotransplantation from pig to cynomolgus monkey: approach toward tolerance induction. Transplant Proc. 1993 Feb; 25(1 Pt 1):336-8.
    View in: PubMed
  299. Sachs DH, Bodine DM, Moulton AD, Pearson DA, Nienhuis AW, Sykes M. Tolerance induction using autologous bone marrow modified with an allogeneic class I MHC gene. Transplant Proc. 1993 Feb; 25(1 Pt 1):348-9.
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  300. Sykes M, Sachs DH, Nienhuis AW, Pearson DA, Moulton AD, Bodine DM. Specific prolongation of skin graft survival following retroviral transduction of bone marrow with an allogeneic major histocompatibility complex gene. Transplantation. 1993 Jan; 55(1):197-202.
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  301. Sykes M, Abraham VS, Harty MW, Pearson DA. IL-2 reduces graft-versus-host disease and preserves a graft-versus-leukemia effect by selectively inhibiting CD4+ T cell activity. J Immunol. 1993 Jan 1; 150(1):197-205.
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  302. Sykes M, Pearson DA. Alloengraftment in IL-2-treated mice. Bone Marrow Transplant. 1992 Aug; 10(2):157-63.
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  303. Abraham VS, Sachs DH, Sykes M. Mechanism of protection from graft-versus-host disease mortality by IL-2. III. Early reductions in donor T cell subsets and expansion of a CD3+CD4-CD8- cell population. J Immunol. 1992 Jun 15; 148(12):3746-52.
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  304. Aksentijevich I, Sachs DH, Sykes M. Humoral tolerance in xenogeneic BMT recipients conditioned by a nonmyeloablative regimen. Transplantation. 1992 May; 53(5):1108-14.
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  305. Sykes M, Abraham VS. The mechanism of IL-2-mediated protection against GVHD in mice. II. Protection occurs independently of NK/LAK cells. Transplantation. 1992 May; 53(5):1063-70.
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  306. Nakajima K, Smith CV, Mixon A, Sykes M, Guzzetta PC, Spitzer TR, Eckhaus MA, Sachs DH. In vitro and in vivo effects of recombinant human interleukin-2 in naive miniature swine. J Immunother (1991). 1992 Apr; 11(3):169-75.
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  307. Sykes M, Sachs DH, Aksentijevich I. Effect of natural antibody on xenogeneic bone marrow engraftment. Transplant Proc. 1992 Apr; 24(2):497-8.
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  308. Sykes M. Dissociating graft-vs-host disease from the graft-vs-leukemia effect of allogeneic T cells: the potential role of IL-2. Bone Marrow Transplant. 1992; 10 Suppl 1:1-4.
    View in: PubMed
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