Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Xuebin Qin, Ph.D., M.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Lab for Translational Research
75 Francis St
Boston MA 02115
Phone617/621-6102
Fax617/621-6148

 Biography 
 awards and honors
1992 - 1992Excellent Doctor
1995 - Golden Award, Tongling Advancement of Science, Investigation of the Etiology of Mental Retardation
1995 - Silver Award,Tongling Advancement of Science for Establishing Genetic Methods for Prenatal Diagnosis
1996 - Anhui Health Award
2000 - 2006Honorary Associate Professor of Binzhou Medical School, China
2003 - Poster of Distinction Award, 2003 Brigham and Women’s Hospital Research Council
2008 - Junior Investigator
2008 - Travel Award

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Liang S, Qin X. Critical role of type I interferon-induced macrophage necroptosis during infection with Salmonella enterica serovar Typhimurium. Cell Mol Immunol. 2013 Mar; 10(2):99-100.
    View in: PubMed
  2. Yan RQ, Chen JL, Gao LJ, Yang YJ, Li JJ, Qiao SB, Xu B, Yao M, Qin XW, Liu HB, Wu YJ, Yuan JQ, Chen J, You SJ, Dai J, Gao RL. Sirolimus-eluting stents for treatment of drug-eluting versus bare-metal stents restenosis: 42-month clinical outcomes from a Chinese single center. Chin Med J (Engl). 2012 Oct; 125(19):3398-403.
    View in: PubMed
  3. Wang Y, Chen W, Yang C, Wu W, Wu S, Qin X, Li X. Long non-coding RNA UCA1a(CUDR) promotes proliferation and tumorigenesis of bladder cancer. Int J Oncol. 2012 Jul; 41(1):276-84.
    View in: PubMed
  4. Soltys J, Halperin JA, Xuebin Q. DAF/CD55 and Protectin/CD59 modulate adaptive immunity and disease outcome in experimental autoimmune myasthenia gravis. J Neuroimmunol. 2012 Mar; 244(1-2):63-9.
    View in: PubMed
  5. Wu L, Su S, Liu F, Xu T, Wang X, Huang Y, Sun X, Ge X, Chen T, Liu H, Wang C, Chorev M, Xu T, Qin X. Removal of the Tag from His-tagged ILYd4, a Human CD59 Inhibitor, Significantly Improves its Physical Properties and its Activity. Curr Pharm Des. 2012; 18(27):4187-96.
    View in: PubMed
  6. Amet T, Ghabril M, Chalasani N, Byrd D, Hu N, Grantham A, Liu Z, Qin X, He JJ, Yu Q. CD59 incorporation protects hepatitis C virus against complement-mediated destruction. Hepatology. 2012 Feb; 55(2):354-63.
    View in: PubMed
  7. Zhang J, Hu W, Xing W, You T, Xu J, Qin X, Peng Z. The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury. Am J Pathol. 2011 Dec; 179(6):2876-84.
    View in: PubMed
  8. Ge X, Wu L, Hu W, Fernandes S, Wang C, Li X, Brown JR, Qin X. rILYd4, a human CD59 inhibitor, enhances complement-dependent cytotoxicity of ofatumumab against rituximab-resistant B-cell lymphoma cells and chronic lymphocytic leukemia. Clin Cancer Res. 2011 Nov 1; 17(21):6702-11.
    View in: PubMed
  9. Sun H, Teng M, Liu J, Jin D, Wu J, Yan D, Fan J, Qin X, Tang H, Peng Z. FOXM1 expression predicts the prognosis in hepatocellular carcinoma patients after orthotopic liver transplantation combined with the Milan criteria. Cancer Lett. 2011 Jul 28; 306(2):214-22.
    View in: PubMed
  10. Sun HC, Li M, Lu JL, Yan DW, Zhou CZ, Fan JW, Qin XB, Tang HM, Peng ZH. Overexpression of Forkhead box M1 protein associates with aggressive tumor features and poor prognosis of hepatocellular carcinoma. Oncol Rep. 2011 Jun; 25(6):1533-9.
    View in: PubMed
  11. You T, Hu W, Ge X, Shen J, Qin X. Application of a novel inhibitor of human CD59 for the enhancement of complement-dependent cytolysis on cancer cells. Cell Mol Immunol. 2011 Mar; 8(2):157-63.
    View in: PubMed
  12. Hu W, Ge X, You T, Xu T, Zhang J, Wu G, Peng Z, Chorev M, Aktas BH, Halperin JA, Brown JR, Qin X. Human CD59 inhibitor sensitizes rituximab-resistant lymphoma cells to complement-mediated cytolysis. Cancer Res. 2011 Mar 15; 71(6):2298-307.
    View in: PubMed
  13. Hu W, Jin R, Zhang J, You T, Peng Z, Ge X, Bronson RT, Halperin JA, Loscalzo J, Qin X. The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model. Blood. 2010 Sep 2; 116(9):1613-22.
    View in: PubMed
  14. Ziegeler G, Ming J, Koseki JC, Sevinc S, Chen T, Ergun S, Qin X, Aktas BH. Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1. J Biol Chem. 2010 May 14; 285(20):15408-19.
    View in: PubMed
  15. Yu Q, Yu R, Qin X. The good and evil of complement activation in HIV-1 infection. Cell Mol Immunol. 2010 Sep; 7(5):334-40.
    View in: PubMed
  16. Wu G, Chen T, Shahsafaei A, Hu W, Bronson RT, Shi GP, Halperin JA, Aktas H, Qin X. Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice. Circulation. 2010 Mar 23; 121(11):1338-46.
    View in: PubMed
  17. Hu W, Yu Q, Hu N, Byrd D, Amet T, Shikuma C, Shiramizu B, Halperin JA, Qin X. A high-affinity inhibitor of human CD59 enhances complement-mediated virolysis of HIV-1: implications for treatment of HIV-1/AIDS. J Immunol. 2010 Jan 1; 184(1):359-68.
    View in: PubMed
  18. Tang H, Lu D, Pan R, Qin X, Xiong H, Dong J. Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats. Life Sci. 2009 Jul 3; 85(1-2):1-10.
    View in: PubMed
  19. Qin X, Hu W, Song W, Blair P, Wu G, Hu X, Song Y, Bauer S, Feelisch M, Leopold JA, Loscalzo J, Halperin JA. Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am J Hematol. 2009 Apr; 84(4):221-7.
    View in: PubMed
  20. Qin X, Hu W, Song W, Grubissich L, Hu X, Wu G, Ferris S, Dobarro M, Halperin JA. Generation and phenotyping of mCd59a and mCd59b double-knockout mice. Am J Hematol. 2009 Feb; 84(2):65-70.
    View in: PubMed
  21. Pan H, Shen Z, Mukhopadhyay P, Wang H, Pacher P, Qin X, Gao B. Anaphylatoxin C5a contributes to the pathogenesis of cisplatin-induced nephrotoxicity. Am J Physiol Renal Physiol. 2009 Mar; 296(3):F496-504.
    View in: PubMed
  22. Wu G, Hu W, Shahsafaei A, Song W, Dobarro M, Sukhova GK, Bronson RR, Shi GP, Rother RP, Halperin JA, Qin X. Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. Circ Res. 2009 Feb 27; 104(4):550-8.
    View in: PubMed
  23. Zhou X, Hu W, Qin X. The role of complement in the mechanism of action of rituximab for B-cell lymphoma: implications for therapy. Oncologist. 2008 Sep; 13(9):954-66.
    View in: PubMed
  24. Hu W, Ferris SP, Tweten RK, Wu G, Radaeva S, Gao B, Bronson RT, Halperin JA, Qin X. Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin. Nat Med. 2008 Jan; 14(1):98-103.
    View in: PubMed
  25. Zhang Q, Xu B, Yang YJ, Zhang RY, Li JP, Qiao SB, Zhang JS, Hu J, Qin XW, Hong T, Chen JL, Huo Y, Shen WF, Gao RL. Sirolimus-eluting cobalt alloyed stents in treating patients with coronary artery disease: six-month angiographic and one-year clinical follow-up result. A prospective, historically controlled, multi-center clinical study. Chin Med J (Engl). 2007 Apr 5; 120(7):533-8.
    View in: PubMed
  26. Qin X, Gao B. The complement system in liver diseases. Cell Mol Immunol. 2006 Oct; 3(5):333-40.
    View in: PubMed
  27. Qin X, Ferris S, Hu W, Guo F, Ziegeler G, Halperin JA. Analysis of the promoters and 5'-UTR of mouse Cd59 genes, and of their functional activity in erythrocytes. Genes Immun. 2006 Jun; 7(4):287-97.
    View in: PubMed
  28. Qin X, Dobarro M, Bedford SJ, Ferris S, Miranda PV, Bronson RT, Visconti PE, & Halperin JA. Further characterization of the reproductive abnormalities in mCd59b knockout mice: A potential new function of mCd59 in male reproduction . Journal of Immunolgy. 2005; 175(10):6294-9302.
  29. Acosta J, Qin X, Halperin J. Complement and complement regulatory proteins as potential molecular targets for vascular diseases. Curr Pharm Des. 2004; 10(2):203-11.
    View in: PubMed
  30. Qin X, Krumrei N, Grubissich L, Dobarro M, Aktas H, Perez G, Halperin JA. Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility. Immunity. 2003 Feb; 18(2):217-27.
    View in: PubMed
  31. Gao H, Boustany RM, Espinola JA, Cotman SL, Srinidhi L, Antonellis KA, Gillis T, Qin X, Liu S, Donahue LR, Bronson RT, Faust JR, Stout D, Haines JL, Lerner TJ, MacDonald ME. Mutations in a novel CLN6-encoded transmembrane protein cause variant neuronal ceroid lipofuscinosis in man and mouse. Am J Hum Genet. 2002 Feb; 70(2):324-35.
    View in: PubMed
  32. Qin X, Miwa T, Aktas H, Gao M, Lee C, Qian Y-M, Morton C, Shahsafaei A, Song W, Halperin JA. Genomic structure, functional comparison, and tissue distribution of mouse Cd59a and Cd59b. Mammalian Genome. 2001; 12:582-589.
  33. Qian YM, Qin X, Miwa T, Sun X, Halperin JA, Song WC. Identification and functional characterization of a new gene encoding the mouse terminal complement inhibitor CD59. J Immunol. 2000 Sep 1; 165(5):2528-34.
    View in: PubMed
  34. Qin X, Shen Y, Wu G. Isolation of 28 new STSs at Xq27.3. Acta Academiae Medicinae Sinicae. 1997; 19(1):1-5.
  35. Chen Z, Fan Y, Zhu N, Qin X, Shen Y, Wu G. Study on the polymorphism of intron 13 (CA)n repeat within FVIII gene in Chinese and its application for the diagnosis of hemophilia A. Journal of Chinese Blood. 1996; 17(3):121-124.
  36. Qin X, Shen Y, Wu G. Construction of a Chinese cosmid library. Acta Academiae Medicinae Sinicae. 1996; 18(5):333-337.
  37. Huang T, Lan-Ying L, Shen Y, Qin X, Wu G. Alternative splicing expression of FMR-1 gene in human fetal neuron. Am J Med Genet. 1996; 64(2):252-255.
  38. Qin X. Artificial chromosome vector system as important tools in genome and gene function researches. Foreign Medical Science (Genetics). 1995; 18(5):250-252.
  39. Qin X. Molecular mechanism of fragile X syndrome. Foreign Medical Science (Genetics). 1995; 18(2):78-80.
  40. Chai J, Shen Y, Fan Y, Qin X, Wu G. Detection of hypermethylation in affected males with fragile X syndrome by PCR assay. Acta Academiae Medicinae Sinicae. 1995; 17(1):47-51.
  41. Fu S, Shen Y, Fan Y, Qin X, Wu G. Unstable DNA sequence and methylation in fragile X syndrome. National Medical Journal of China. 1994; 74(10):611-614.
  42. Qin X, Yong A. A study of fragile X syndrome in cytogenetics and clinic characteristics. Chinese Journal of Medical Genetics. 1993; 10(1):14–17.
  43. Qin X, Yong A. An explanation of the genetic phenomena of 4 fragile X families by using Laird's X-inactivation imprinting hypotheses. Chinese Journal of Medical Genetics. 1993; 10(2):119-120.
  44. Qin X, Yong A. Looking for an internal control system for fragile X induction system. Chinese Journal of Medical Genetics. 1992; 9(6):354-355.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Qin's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
See all (242) concept(s)
_
Co-Authors
See all (11) people
_
Similar People
See all (60) people
_
Same Department
Search Department
Physical Neighbors
_