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Jonathan M.G. Higgins, PH.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Women's Hospital
Smith 538A Rheumatology, Immunology & Allergy
1 Jimmy Fund Way
Boston MA 02115
Phone617/525-1105
Fax617/525-1010

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang F, Higgins JM. Histone modifications and mitosis: countermarks, landmarks, and bookmarks. Trends Cell Biol. 2013 Apr; 23(4):175-84.
    View in: PubMed
  2. Wang F, Ulyanova NP, Daum JR, Patnaik D, Kateneva AV, Gorbsky GJ, Higgins JM. Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation. J Cell Biol. 2012 Oct 15; 199(2):251-68.
    View in: PubMed
  3. Niedzialkowska E, Wang F, Porebski PJ, Minor W, Higgins JM, Stukenberg PT. Molecular basis for phosphospecific recognition of histone H3 tails by Survivin paralogues at inner centromeres. Mol Biol Cell. 2012 Apr; 23(8):1457-66.
    View in: PubMed
  4. Cuny GD, Ulyanova NP, Patnaik D, Liu JF, Lin X, Auerbach K, Ray SS, Xian J, Glicksman MA, Stein RL, Higgins JM. Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorg Med Chem Lett. 2012 Mar 1; 22(5):2015-9.
    View in: PubMed
  5. Wang F, Ulyanova NP, van der Waal MS, Patnaik D, Lens SM, Higgins JM. A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis. Curr Biol. 2011 Jun 21; 21(12):1061-9.
    View in: PubMed
  6. Czakai K, Müller K, Mosesso P, Pepe G, Schulze M, Gohla A, Patnaik D, Dekant W, Higgins JM, Mally A. Perturbation of mitosis through inhibition of histone acetyltransferases: the key to ochratoxin a toxicity and carcinogenicity? Toxicol Sci. 2011 Aug; 122(2):317-29.
    View in: PubMed
  7. Varier RA, Outchkourov NS, de Graaf P, van Schaik FM, Ensing HJ, Wang F, Higgins JM, Kops GJ, Timmers HT. A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes. EMBO J. 2010 Dec 1; 29(23):3967-78.
    View in: PubMed
  8. Wang F, Dai J, Daum JR, Niedzialkowska E, Banerjee B, Stukenberg PT, Gorbsky GJ, Higgins JM. Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis. Science. 2010 Oct 8; 330(6001):231-5.
    View in: PubMed
  9. Cuny GD, Robin M, Ulyanova NP, Patnaik D, Pique V, Casano G, Liu JF, Lin X, Xian J, Glicksman MA, Stein RL, Higgins JM. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15; 20(12):3491-4.
    View in: PubMed
  10. Higgins JM. Haspin: a newly discovered regulator of mitotic chromosome behavior. Chromosoma. 2010 Apr; 119(2):137-47.
    View in: PubMed
  11. Eswaran J, Patnaik D, Filippakopoulos P, Wang F, Stein RL, Murray JW, Higgins JM, Knapp S. Structure and functional characterization of the atypical human kinase haspin. Proc Natl Acad Sci U S A. 2009 Dec 1; 106(48):20198-203.
    View in: PubMed
  12. Dai J, Kateneva AV, Higgins JM. Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion. J Cell Sci. 2009 Nov 15; 122(Pt 22):4168-76.
    View in: PubMed
  13. Kateneva AV, Higgins JM. Shugoshin and PP2A: collaborating to keep chromosomes connected. Dev Cell. 2009 Sep; 17(3):303-5.
    View in: PubMed
  14. Patnaik D, Glicksman MA, Cuny GD, Stein RL, Higgins JM. Identification of small molecule inhibitors of the mitotic kinase haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assay. J Biomol Screen. 2008 Dec; 13(10):1025-34.
    View in: PubMed
  15. Metzger E, Yin N, Wissmann M, Kunowska N, Fischer K, Friedrichs N, Patnaik D, Higgins JM, Potier N, Scheidtmann KH, Buettner R, Schüle R. Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation. Nat Cell Biol. 2008 Jan; 10(1):53-60.
    View in: PubMed
  16. Parisini E, Higgins JM, Liu JH, Brenner MB, Wang JH. The crystal structure of human E-cadherin domains 1 and 2, and comparison with other cadherins in the context of adhesion mechanism. J Mol Biol. 2007 Oct 19; 373(2):401-11.
    View in: PubMed
  17. Dai J, Sullivan BA, Higgins JM. Regulation of mitotic chromosome cohesion by Haspin and Aurora B. Dev Cell. 2006 Nov; 11(5):741-50.
    View in: PubMed
  18. Kiener HP, Stipp CS, Allen PG, Higgins JM, Brenner MB. The cadherin-11 cytoplasmic juxtamembrane domain promotes alpha-catenin turnover at adherens junctions and intercellular motility. Mol Biol Cell. 2006 May; 17(5):2366-76.
    View in: PubMed
  19. Dai J, Higgins JM. Haspin: a mitotic histone kinase required for metaphase chromosome alignment. Cell Cycle. 2005 May; 4(5):665-8.
    View in: PubMed
  20. Dai J, Sultan S, Taylor SS, Higgins JM. The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment. Genes Dev. 2005 Feb 15; 19(4):472-88.
    View in: PubMed
  21. Valencia X, Higgins JM, Kiener HP, Lee DM, Podrebarac TA, Dascher CC, Watts GF, Mizoguchi E, Simmons B, Patel DD, Bhan AK, Brenner MB. Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes. J Exp Med. 2004 Dec 20; 200(12):1673-9.
    View in: PubMed
  22. Hintermann E, Yang N, O'Sullivan D, Higgins JM, Quaranta V. Integrin alpha6beta4-erbB2 complex inhibits haptotaxis by up-regulating E-cadherin cell-cell junctions in keratinocytes. J Biol Chem. 2005 Mar 4; 280(9):8004-15.
    View in: PubMed
  23. Higgins JM. Structure, function and evolution of haspin and haspin-related proteins, a distinctive group of eukaryotic protein kinases. Cell Mol Life Sci. 2003 Mar; 60(3):446-62.
    View in: PubMed
  24. Kilshaw PJ, Higgins JM. Alpha E: no more rejection? J Exp Med. 2002 Oct 7; 196(7):873-5.
    View in: PubMed
  25. Higgins JM. Haspin-like proteins: a new family of evolutionarily conserved putative eukaryotic protein kinases. Protein Sci. 2001 Aug; 10(8):1677-84.
    View in: PubMed
  26. Higgins JM. The Haspin gene: location in an intron of the integrin alphaE gene, associated transcription of an integrin alphaE-derived RNA and expression in diploid as well as haploid cells. Gene. 2001 Apr 4; 267(1):55-69.
    View in: PubMed
  27. Bono P, Rubin K, Higgins JM, Hynes RO. Layilin, a novel integral membrane protein, is a hyaluronan receptor. Mol Biol Cell. 2001 Apr; 12(4):891-900.
    View in: PubMed
  28. Strauch UG, Mueller RC, Li XY, Cernadas M, Higgins JM, Binion DG, Parker CM. Integrin alpha E(CD103)beta 7 mediates adhesion to intestinal microvascular endothelial cell lines via an E-cadherin-independent interaction. J Immunol. 2001 Mar 1; 166(5):3506-14.
    View in: PubMed
  29. Agace WW, Higgins JM, Sadasivan B, Brenner MB, Parker CM. T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines. Curr Opin Cell Biol. 2000 Oct; 12(5):563-8.
    View in: PubMed
  30. Higgins JM, Cernadas M, Tan K, Irie A, Wang J, Takada Y, Brenner MB. The role of alpha and beta chains in ligand recognition by beta 7 integrins. J Biol Chem. 2000 Aug 18; 275(33):25652-64.
    View in: PubMed
  31. Taraszka KS, Higgins JM, Tan K, Mandelbrot DA, Wang JH, Brenner MB. Molecular basis for leukocyte integrin alpha(E)beta(7) adhesion to epithelial (E)-cadherin. J Exp Med. 2000 May 1; 191(9):1555-67.
    View in: PubMed
  32. Li Z, Kim SH, Higgins JM, Brenner MB, Sacks DB. IQGAP1 and calmodulin modulate E-cadherin function. J Biol Chem. 1999 Dec 31; 274(53):37885-92.
    View in: PubMed
  33. Higgins JM, Mandlebrot DA, Shaw SK, Russell GJ, Murphy EA, Chen YT, Nelson WJ, Parker CM, Brenner MB. Direct and regulated interaction of integrin alphaEbeta7 with E-cadherin. J Cell Biol. 1998 Jan 12; 140(1):197-210.
    View in: PubMed
  34. Higgins JM, Wiedemann H, Timpl R, Reid KB. Characterization of mutant forms of recombinant human properdin lacking single thrombospondin type I repeats. Identification of modules important for function. J Immunol. 1995 Dec 15; 155(12):5777-85.
    View in: PubMed
  35. Nolan KF, Kaluz S, Higgins JM, Goundis D, Reid KB. Characterization of the human properdin gene. Biochem J. 1992 Oct 1; 287 ( Pt 1):291-7.
    View in: PubMed
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