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Dan Gabriel Fraenkel, PH.D.

TitleProfessor of Microbiology and Molecular Genetics, Emeritus
InstitutionHarvard Medical School
DepartmentEmeritus
AddressHarvard Inst of Medicine
Microbiology and Immunobiology, Room 1046
4 Blackfan Cir
Boston MA 02115
Phone617/432-1912
Fax617/738-7664
Other Positions
TitleSenior Lecturer on Microbiology and Immunobiology
InstitutionHarvard Medical School
DepartmentMicrobiology and Immunobiology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Fraenkel DG. The top genes: on the distance from transcript to function in yeast glycolysis. Curr Opin Microbiol. 2003 Apr; 6(2):198-201.
    View in: PubMed
  2. Heidrich K, Fraenkel DG. Setting of graded levels of a protein in yeast by a t-degron technique as applied to phosphoglycerate mutase. BMC Genet. 2002 Jul 30; 3:13.
    View in: PubMed
  3. Uemura H, Fraenkel DG. Glucose metabolism in gcr mutants of Saccharomyces cerevisiae. J Bacteriol. 1999 Aug; 181(15):4719-23.
    View in: PubMed
  4. Benevolensky SV, Clifton D, Fraenkel DG. The effect of increased phosphoglucose isomerase on glucose metabolism in Saccharomyces cerevisiae. J Biol Chem. 1994 Feb 18; 269(7):4878-82.
    View in: PubMed
  5. Kriegel TM, Rush J, Vojtek AB, Clifton D, Fraenkel DG. In vivo phosphorylation site of hexokinase 2 in Saccharomyces cerevisiae. Biochemistry. 1994 Jan 11; 33(1):148-52.
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  6. Clifton D, Walsh RB, Fraenkel DG. Functional studies of yeast glucokinase. J Bacteriol. 1993 Jun; 175(11):3289-94.
    View in: PubMed
  7. Babul J, Clifton D, Kretschmer M, Fraenkel DG. Glucose metabolism in Escherichia coli and the effect of increased amount of aldolase. Biochemistry. 1993 May 4; 32(17):4685-92.
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  8. Fraenkel DG. Genetics and intermediary metabolism. Annu Rev Genet. 1992; 26:159-77.
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  9. Kretschmer M, Fraenkel DG. Yeast 6-phosphofructo-2-kinase: sequence and mutant. Biochemistry. 1991 Nov 5; 30(44):10663-72.
    View in: PubMed
  10. Walsh RB, Clifton D, Horak J, Fraenkel DG. Saccharomyces cerevisiae null mutants in glucose phosphorylation: metabolism and invertase expression. Genetics. 1991 Jul; 128(3):521-7.
    View in: PubMed
  11. Kretschmer M, Tempst P, Fraenkel DG. Identification and cloning of yeast phosphofructokinase 2. Eur J Biochem. 1991 Apr 23; 197(2):367-72.
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  12. Uemura H, Fraenkel DG. gcr2, a new mutation affecting glycolytic gene expression in Saccharomyces cerevisiae. Mol Cell Biol. 1990 Dec; 10(12):6389-96.
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  13. Vojtek AB, Fraenkel DG. Phosphorylation of yeast hexokinases. Eur J Biochem. 1990 Jun 20; 190(2):371-5.
    View in: PubMed
  14. Babul J, Fraenkel DG. Phosphate modification of fructose-1,6-bisphosphate aldolase in Escherichia coli. Biochem Biophys Res Commun. 1988 Mar 30; 151(3):1033-8.
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  15. Bisson LF, Neigeborn L, Carlson M, Fraenkel DG. The SNF3 gene is required for high-affinity glucose transport in Saccharomyces cerevisiae. J Bacteriol. 1987 Apr; 169(4):1656-62.
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  16. Sedivy JM, Babul J, Fraenkel DG. AMP-insensitive fructose bisphosphatase in Escherichia coli and its consequences. Proc Natl Acad Sci U S A. 1986 Mar; 83(6):1656-9.
    View in: PubMed
  17. Fraenkel DG. Mutants in glucose metabolism. Annu Rev Biochem. 1986; 55:317-37.
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  18. Sedivy JM, Fraenkel DG. Fructose bisphosphatase of Saccharomyces cerevisiae. Cloning, disruption and regulation of the FBP1 structural gene. J Mol Biol. 1985 Nov 20; 186(2):307-19.
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  19. Fraenkel DG. On ras gene function in yeast. Proc Natl Acad Sci U S A. 1985 Jul; 82(14):4740-4.
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  20. Bisson LF, Fraenkel DG. Expression of kinase-dependent glucose uptake in Saccharomyces cerevisiae. J Bacteriol. 1984 Sep; 159(3):1013-7.
    View in: PubMed
  21. Sedivy JM, Daldal F, Fraenkel DG. Fructose bisphosphatase of Escherichia coli: cloning of the structural gene (fbp) and preparation of a chromosomal deletion. J Bacteriol. 1984 Jun; 158(3):1048-53.
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  22. Bisson LF, Fraenkel DG. Transport of 6-deoxyglucose in Saccharomyces cerevisiae. J Bacteriol. 1983 Sep; 155(3):995-1000.
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  23. Clifton D, Fraenkel DG. Fructose 2,6-bisphosphate and fructose-6-P 2-kinase in Saccharomyces cerevisiae in relation to metabolic state in wild type and fructose-6-P 1-kinase mutant strains. J Biol Chem. 1983 Aug 10; 258(15):9245-9.
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  24. Walsh RB, Kawasaki G, Fraenkel DG. Cloning of genes that complement yeast hexokinase and glucokinase mutants. J Bacteriol. 1983 May; 154(2):1002-4.
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  25. Bisson LF, Fraenkel DG. Involvement of kinases in glucose and fructose uptake by Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 1983 Mar; 80(6):1730-4.
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  26. Daldal F, Fraenkel DG. Assessment of a futile cycle involving reconversion of fructose 6-phosphate to fructose 1,6-bisphosphate during gluconeogenic growth of Escherichia coli. J Bacteriol. 1983 Jan; 153(1):390-4.
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  27. Kawasaki G, Fraenkel DG. Cloning of yeast glycolysis genes by complementation. Biochem Biophys Res Commun. 1982 Oct 15; 108(3):1107-22.
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  28. Daldal F, Babul J, Guixé V, Fraenkel DG. An alteration in phosphofructokinase 2 of Escherichia coli which impairs gluconeogenic growth and improves growth on sugars. Eur J Biochem. 1982 Aug; 126(2):373-9.
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  29. Bañuelos M, Fraenkel DG. Saccharomyces carlsbergensis fdp mutant and futile cycling of fructose 6-phosphate. Mol Cell Biol. 1982 Aug; 2(8):921-9.
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  30. Clifton D, Fraenkel DG. Mutant studies of yeast phosphofructokinase. Biochemistry. 1982 Apr 13; 21(8):1935-42.
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  31. Clifton D, Fraenkel DG. The gcr (glycolysis regulation) mutation of Saccharomyces cerevisiae. J Biol Chem. 1981 Dec 25; 256(24):13074-8.
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  32. Daldal F, Fraenkel DG. Tn10 insertions in the pfkB region of Escherichia coli. J Bacteriol. 1981 Sep; 147(3):935-43.
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  33. Fraenkel DG. The biochemical genetics of glycolysis in microbes. Basic Life Sci. 1981; 18:201-15.
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  34. Chambost JP, Fraenkel DG. The use of 6-labeled glucose to assess futile cycling in Escherichia coli. J Biol Chem. 1980 Apr 10; 255(7):2867-9.
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  35. de Silva AO, Fraenkel DG. The 6-phosphogluconate dehydrogenase reaction in Escherichia coli. J Biol Chem. 1979 Oct 25; 254(20):10237-42.
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  36. Duncan MJ, Fraenkel DG. alpha-Ketoglutarate dehydrogenase mutant of Rhizobium meliloti. J Bacteriol. 1979 Jan; 137(1):415-9.
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  37. Thomson J, Gerstenberger PD, Goldberg DE, Gociar E, Orozco de Silva A, Fraenkel DG. ColE1 hybrid plasmids for Escherichia coli genes of glycolysis and the hexose monophosphate shunt. J Bacteriol. 1979 Jan; 137(1):502-6.
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  38. Robinson JP, Fraenkel DG. Allosteric and non-allosteric E. coli phosphofructokinases: effects on growth. Biochem Biophys Res Commun. 1978 Apr 14; 81(3):858-63.
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  39. Clifton D, Weinstock SB, Fraenkel DG. Glycolysis mutants in Saccharomyces cerevisiae. Genetics. 1978 Jan; 88(1):1-11.
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  40. Gancedo JM, Clifton D, Fraenkel DG. Yeast hexokinase mutants. J Biol Chem. 1977 Jul 10; 252(13):4443-4.
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  41. Csonka LN, Fraenkel DG. Pathways of NADPH formation in Escherichia coli. J Biol Chem. 1977 May 25; 252(10):3382-91.
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  42. Babul J, Robinson JP, Fraenkel DG. Are the aerobic and anaerobic phosphofructokinases of Escherichia coli different? Eur J Biochem. 1977 Apr 15; 74(3):533-7.
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  43. Hillman JD, Fraenkel DG. Glyceraldehyde 3-phosphate dehydrogenase mutants of Escherichia coli. J Bacteriol. 1975 Jun; 122(3):1175-9.
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  44. Vinopal RT, Clifton D, Fraenkel DG. PfkA locus of Escherichia coli. J Bacteriol. 1975 Jun; 122(3):1162-71.
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  45. Vinopal RT, Hillman JD, Schulman H, Reznikoff WS, Fraenkel DG. New phosphoglucose isomerase mutants of Escherichia coli. J Bacteriol. 1975 Jun; 122(3):1172-4.
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  46. Vinopal RT, Fraenkel DG. PfkB and pfkC loci of Escherichia coli. J Bacteriol. 1975 Jun; 122(3):1153-61.
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  47. Josephson BL, Fraenkel DG. Sugar metabolism in transketolase mutants of Escherichia coli. J Bacteriol. 1974 Jun; 118(3):1082-9.
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  48. Vinopal RT, Fraenkel DG. Phenotypic suppression of phosphofructokinase mutations in Escherichia coli by constitutive expression of the glyoxylate shunt. J Bacteriol. 1974 Jun; 118(3):1090-100.
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  49. Wolf RE, Fraenkel DG. Isolation of specialized transducing bacteriophages for gluconate 6-phosphate dehydrogenase (gnd) of Escherichia coli. J Bacteriol. 1974 Feb; 117(2):468-76.
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  50. Fraenkel DG, Kotlarz D, Buc H. Two fructose 6-phosphate kinase activities in Escherichia coli. J Biol Chem. 1973 Jul 10; 248(13):4865-6.
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  51. Fraenkel DG, Parola A. "Up-promoter" mutations of glucose 6-phosphate dehydrogenase in Escherichia coli. J Mol Biol. 1972 Oct 28; 71(1):107-11.
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  52. Morrissey AT, Fraenkel DG. Suppressor of phosphofructokinase mutations of Escherichia coli. J Bacteriol. 1972 Oct; 112(1):183-7.
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  53. Fraenkel DG, Banerjee S. Deletion mapping of zwf, the gene for a constitutive enzyme, glucose 6-phosphate dehydrogenase in Escherichia coli. Genetics. 1972 Aug; 71(4):481-9.
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  54. Banerjee S, Fraenkel DG. Glucose-6-phosphate dehydrogenase from Escherichia coli and from a "high-level" mutant. J Bacteriol. 1972 Apr; 110(1):155-60.
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  55. Kupor SR, Fraenkel DG. Glucose metabolism in 6 phosphogluconolactonase mutants of Escherichia coli. J Biol Chem. 1972 Mar 25; 247(6):1904-10.
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  56. Fradkin JE, Fraenkel DG. 2-keto-3-deoxygluconate 6-phosphate aldolase mutants of Escherichia coli. J Bacteriol. 1971 Dec; 108(3):1277-83.
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  57. Fraenkel DG, Banerjee S. A mutation increasing the amount of a constitutive enzyme in Escherichia coli, glucose 6-phosphate dehydrogenase. J Mol Biol. 1971 Feb 28; 56(1):183-94.
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  58. Josephson BL, Fraenkel DG. Transketolase mutants of Escherichia coli. J Bacteriol. 1969 Dec; 100(3):1289-95.
    View in: PubMed
  59. Kupor SR, Fraenkel DG. 6-phosphogluconolactonase mutants of Escherichia coli and a maltose blue gene. J Bacteriol. 1969 Dec; 100(3):1296-301.
    View in: PubMed
  60. Morrissey AT, Fraenkel DG. Chromosomal location of a gene for fructose 6-phosphate kinase in Escherichia coli. J Bacteriol. 1969 Nov; 100(2):1108-9.
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  61. Fraenkel DG. The phosphoenolpyruvate-initiated pathway of fructose metabolism in Escherichia coli. J Biol Chem. 1968 Dec 25; 243(24):6458-63.
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  62. Fraenkel DG. The accumulation of glucose 6-phosphate from glucose and its effect in an Escherichia coli mutant lacking phosphoglucose isomerase and glucose 6-phosphate dehydrogenase. J Biol Chem. 1968 Dec 25; 243(24):6451-7.
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  63. Morrissey AT, Fraenkel DG. Selection of fructose 6-phosphate kinase mutants in Escherichia coli. Biochem Biophys Res Commun. 1968 Aug 13; 32(3):467-73.
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  64. Fraenkel DG. Selection of Escherichia coli mutants lacking glucose-6-phosphate dehydrogenase or gluconate-6-phosphate dehydrogenase. J Bacteriol. 1968 Apr; 95(4):1267-71.
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  65. Peyru G, Fraenkel DG. Genetic mapping of loci for glucose-6-phosphate dehydrogenase, gluconate-6-phosphate dehydrogenase, and gluconate-6-phosphate dehydrase in Escherichia coli. J Bacteriol. 1968 Apr; 95(4):1272-8.
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  66. Fraenkel DG, Levisohn SR. Glucose and gluconate metabolism in an Escherichia coli mutant lacking phosphoglucose isomerase. J Bacteriol. 1967 May; 93(5):1571-8.
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  67. Fraenkel DG. Genetic mapping of mutations affecting phosphoglucose isomerase and fructose diphosphatase in Escherichia coli. J Bacteriol. 1967 May; 93(5):1582-7.
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  68. Zablotny R, Fraenkel DG. Glucose and gluconate metabolism in a mutant of Escherichia coli lacking gluconate-6-phosphate dehydrase. J Bacteriol. 1967 May; 93(5):1579-81.
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  69. Tanaka S, Fraenkel DG, Lin EC. The enzymatic lesion of strain MM-6, a pleiotropic carbohydrate-negative mutant of Escherichia coli. Biochem Biophys Res Commun. 1967 Apr 7; 27(1):63-7.
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  70. Fraenkel DG, Pontremoli S, Horecker BL. The specific fructose diphosphatase of Escherichia coli: properties and partial purification. Arch Biochem Biophys. 1966 Apr; 114(1):4-12.
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  71. Fraenkel DG, Horecker BL. Fructose-1, 6-diphosphatase and acid hexose phosphatase of Escherichia coli. J Bacteriol. 1965 Oct; 90(4):837-42.
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  72. FRAENKEL DG, FALCOZ-KELLY F, HORECKER BL. THE UTILIZATION OF GLUCOSE 6-PHOSPHATE BY GLUCOKINASELESS AND WILD-TYPE STRAINS OF ESCHERICHIA COLI. Proc Natl Acad Sci U S A. 1964 Nov; 52:1207-13.
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  73. FRAENKEL DG, HORECKER BL. PATHWAYS OF D-GLUCOSE METABOLISM IN SALMONELLA TYPHINMURIUM. A STUDY OF A MUTANT LACKING PHOSPHOGLUCOSE ISOMERASE. J Biol Chem. 1964 Sep; 239:2765-71.
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  74. FRAENKEL D, OSBORN MJ, HORECKER BL, SMITH SM. Metabolism and cell wall structure of a mutant of Salmonella typhimurium deficient in phosphoglucose isomerase. Biochem Biophys Res Commun. 1963 Jun 20; 11:423-8.
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