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Institution

Shiv S. Pillai, Ph.D., M.D.

TitleProfessor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
MGH Cancer Center
149 13th Street
Charlestown MA 02129
Phone617/726-5619
Fax617/724-9648
Other Positions
TitleProfessor of Health Sciences and Technology
InstitutionMassachusetts General Hospital
DepartmentHealth Sciences and Technology


 Mentoring 
 completed student projects
Understanding the role of SIAE in BCR overactivation in SLE and RA
Summer, 02/01/08 - 06/01/10

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Leadbetter EA, Brigl M, Illarionov P, Cohen N, Luteran MC, Pillai S, Besra GS, Brenner MB. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci U S A. 2008 Jun 17; 105(24):8339-44.
    View in: PubMed
  2. Shimomura Y, Ogawa A, Kawada M, Sugimoto K, Mizoguchi E, Shi HN, Pillai S, Bhan AK, Mizoguchi A. A unique B2 B cell subset in the intestine. J Exp Med. 2008 Jun 9; 205(6):1343-55.
    View in: PubMed
  3. Benatuil L, Kaye J, Cretin N, Godwin JG, Cariappa A, Pillai S, Iacomini J. Ig knock-in mice producing anti-carbohydrate antibodies: breakthrough of B cells producing low affinity anti-self antibodies. J Immunol. 2008 Mar 15; 180(6):3839-48.
    View in: PubMed
  4. Cariappa A, Boboila C, Moran ST, Liu H, Shi HN, Pillai S. The recirculating B cell pool contains two functionally distinct, long-lived, posttransitional, follicular B cell populations. J Immunol. 2007 Aug 15; 179(4):2270-81.
    View in: PubMed
  5. Moran ST, Cariappa A, Liu H, Muir B, Sgroi D, Boboila C, Pillai S. Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes. J Immunol. 2007 Jul 1; 179(1):195-200.
    View in: PubMed
  6. Cariappa A, Chase C, Liu H, Russell P, Pillai S. Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Blood. 2007 Mar 15; 109(6):2339-45.
    View in: PubMed
  7. Moran ST, Cariappa A, Liu H, Boboila C, Shi HN, Holland PM, Peschon JJ, Pillai S. Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations. Mol Immunol. 2006 Apr; 43(10):1694-9.
    View in: PubMed
  8. Cariappa A, Mazo IB, Chase C, Shi HN, Liu H, Li Q, Rose H, Leung H, Cherayil BJ, Russell P, von Andrian U, Pillai S. Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes. Immunity. 2005 Oct; 23(4):397-407.
    View in: PubMed
  9. Cavanagh LL, Bonasio R, Mazo IB, Halin C, Cheng G, van der Velden AW, Cariappa A, Chase C, Russell P, Starnbach MN, Koni PA, Pillai S, Weninger W, von Andrian UH. Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells. Nat Immunol. 2005 Oct; 6(10):1029-37.
    View in: PubMed
  10. Cariappa A, Shoham T, Liu H, Levy S, Boucheix C, Pillai S. The CD9 tetraspanin is not required for the development of peripheral B cells or for humoral immunity. J Immunol. 2005 Sep 1; 175(5):2925-30.
    View in: PubMed
  11. Pillai S. Birth pangs: the stressful origins of lymphocytes. J Clin Invest. 2005 Feb; 115(2):224-7.
    View in: PubMed
  12. Pillai S, Cariappa A, Moran ST. Marginal zone B cells. Annu Rev Immunol. 2005; 23:161-96.
    View in: PubMed
  13. Pillai S, Cariappa A, Moran ST. Positive selection and lineage commitment during peripheral B-lymphocyte development. Immunol Rev. 2004 Feb; 197:206-18.
    View in: PubMed
  14. Cariappa A, Chen L, Haider K, Tang M, Nebelitskiy E, Moran ST, Pillai S. A catalytically inactive form of protein kinase C-associated kinase/receptor interacting protein 4, a protein kinase C beta-associated kinase that mediates NF-kappa B activation, interferes with early B cell development. J Immunol. 2003 Aug 15; 171(4):1875-80.
    View in: PubMed
  15. Moran ST, Haider K, Ow Y, Milton P, Chen L, Pillai S. Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner. J Biol Chem. 2003 Jun 13; 278(24):21526-33.
    View in: PubMed
  16. Pillai S, Moran ST. Tec kinase pathways in lymphocyte development and transformation. Biochim Biophys Acta. 2002 Jun 21; 1602(2):162-7.
    View in: PubMed
  17. Cariappa A, Pillai S. Antigen-dependent B-cell development. Curr Opin Immunol. 2002 Apr; 14(2):241-9.
    View in: PubMed
  18. Kim TJ, Cariappa A, Iacomini J, Tang M, Shih S, Bernards A, Jacks T, Pillai S. Defective proliferative responses in B lymphocytes and thymocytes that lack neurofibromin. Mol Immunol. 2002 Feb; 38(9):701-8.
    View in: PubMed
  19. Maciorowski KG, Pillai SD, Ricke SC. Presence of bacteriophages in animal feed as indicators of fecal contamination. J Environ Sci Health B. 2001 Sep; 36(5):699-708.
    View in: PubMed
  20. Cariappa A, Tang M, Parng C, Nebelitskiy E, Carroll M, Georgopoulos K, Pillai S. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity. 2001 May; 14(5):603-15.
    View in: PubMed
  21. Chen L, Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S. Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase. J Biol Chem. 2001 Jun 15; 276(24):21737-44.
    View in: PubMed
  22. Cariappa A, Liou HC, Horwitz BH, Pillai S. Nuclear factor kappa B is required for the development of marginal zone B lymphocytes. J Exp Med. 2000 Oct 16; 192(8):1175-82.
    View in: PubMed
  23. Chaudhuri S, Cariappa A, Tang M, Bell D, Haber DA, Isselbacher KJ, Finkelstein D, Forcione D, Pillai S. Genetic susceptibility to breast cancer: HLA DQB*03032 and HLA DRB1*11 may represent protective alleles. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21):11451-4.
    View in: PubMed
  24. Ho SC, Chaudhuri S, Bachhawat A, McDonald K, Pillai S. Accelerated proteasomal degradation of membrane Ig heavy chains. J Immunol. 2000 May 1; 164(9):4713-9.
    View in: PubMed
  25. Novina CD, Kumar S, Bajpai U, Cheriyath V, Zhang K, Pillai S, Wortis HH, Roy AL. Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase. Mol Cell Biol. 1999 Jul; 19(7):5014-24.
    View in: PubMed
  26. Pillai S. The chosen few? Positive selection and the generation of naive B lymphocytes. Immunity. 1999 May; 10(5):493-502.
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  27. Cariappa A, Kim TJ, Pillai S. Accelerated emigration of B lymphocytes in the Xid mouse. J Immunol. 1999 Apr 15; 162(8):4417-23.
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  28. Ho SC, Rajagopalan S, Chaudhuri S, Shieh CC, Brenner MB, Pillai S. Membrane anchoring of calnexin facilitates its interaction with its targets. Mol Immunol. 1999 Jan; 36(1):1-12.
    View in: PubMed
  29. Wang JH, Avitahl N, Cariappa A, Friedrich C, Ikeda T, Renold A, Andrikopoulos K, Liang L, Pillai S, Morgan BA, Georgopoulos K. Aiolos regulates B cell activation and maturation to effector state. Immunity. 1998 Oct; 9(4):543-53.
    View in: PubMed
  30. Cariappa A, Sands B, Forcione D, Finkelstein D, Podolsky DK, Pillai S. Analysis of MHC class II DP, DQ and DR alleles in Crohn's disease. Gut. 1998 Aug; 43(2):210-5.
    View in: PubMed
  31. Chen L, Kim TJ, Pillai S. Inhibition of caspase activity prevents anti-IgM induced apoptosis but not ceramide generation in WEHI 231 B cells. Mol Immunol. 1998 Mar; 35(4):195-205.
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  32. Snijders AJ, Ho SC, Haase VH, Pillai S, Bernards A. A lymphocyte-specific Ltk tyrosine kinase isoform is retained in the endoplasmic reticulum in association with calnexin. J Biol Chem. 1997 Jan 10; 272(2):1297-301.
    View in: PubMed
  33. Forcione DG, Sands B, Isselbacher KJ, Rustgi A, Podolsky DK, Pillai S. An increased risk of Crohn's disease in individuals who inherit the HLA class II DRB3*0301 allele. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):5094-8.
    View in: PubMed
  34. Kim TJ, Kim YT, Pillai S. Association of activated phosphatidylinositol 3-kinase with p120cbl in antigen receptor-ligated B cells. J Biol Chem. 1995 Nov 17; 270(46):27504-9.
    View in: PubMed
  35. Aoki Y, Kim YT, Stillwell R, Kim TJ, Pillai S. The SH2 domains of Src family kinases associate with Syk. J Biol Chem. 1995 Jun 30; 270(26):15658-63.
    View in: PubMed
  36. Aoki Y, Isselbacher KJ, Pillai S. Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10606-9.
    View in: PubMed
  37. Aoki Y, Isselbacher KJ, Cherayil BJ, Pillai S. Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4204-8.
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  38. Aoki Y, Lee JC, Pillai S, Isselbacher KJ, Rustgi AK. Radiolabeled polymerase chain reaction assay for detection of ras oncogene point mutations in tumors. Clin Chem. 1994 May; 40(5):705-9.
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  39. Lee JC, Pillai S. Complete nucleotide sequence of MHC class I alleles in the HT29 colon cancer cell line. Tissue Antigens. 1993 Nov; 42(5):530-2.
    View in: PubMed
  40. Cherayil BJ, MacDonald K, Waneck GL, Pillai S. Surface transport and internalization of the membrane IgM H chain in the absence of the Mb-1 and B29 proteins. J Immunol. 1993 Jul 1; 151(1):11-9.
    View in: PubMed
  41. Rosenberg IM, Iyer R, Cherayil B, Chiodino C, Pillai S. Structure of the murine Mac-2 gene. Splice variants encode proteins lacking functional signal peptides. J Biol Chem. 1993 Jun 15; 268(17):12393-400.
    View in: PubMed
  42. Aoki Y, Isselbacher KJ, Pillai S. Polymorphisms involving the transmembrane domains of human TAP2. Immunogenetics. 1993; 38(5):382.
    View in: PubMed
  43. Galvin K, Krishna S, Ponchel F, Frohlich M, Cummings DE, Carlson R, Wands JR, Isselbacher KJ, Pillai S, Ozturk M. The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene. Proc Natl Acad Sci U S A. 1992 Sep 15; 89(18):8452-6.
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  44. Krishna S, Benaroch P, Pillai S. Tetrameric cell-surface MHC class I molecules. Nature. 1992 May 14; 357(6374):164-7.
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  45. Bachhawat AK, Pillai S. Distinct intracellular fates of membrane and secretory immunoglobulin heavy chains in a pre-B cell line. J Cell Biol. 1991 Nov; 115(3):619-24.
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  46. Rosenberg I, Cherayil BJ, Isselbacher KJ, Pillai S. Mac-2-binding glycoproteins. Putative ligands for a cytosolic beta-galactoside lectin. J Biol Chem. 1991 Oct 5; 266(28):18731-6.
    View in: PubMed
  47. Pillai S. Immunoglobulin transport in B cell development. Int Rev Cytol. 1991; 130:1-36.
    View in: PubMed
  48. Cherayil BJ, Pillai S. The omega/lambda 5 surrogate immunoglobulin light chain is expressed on the surface of transitional B lymphocytes in murine bone marrow. J Exp Med. 1991 Jan 1; 173(1):111-6.
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  49. Cherayil BJ, Chaitovitz S, Wong C, Pillai S. Molecular cloning of a human macrophage lectin specific for galactose. Proc Natl Acad Sci U S A. 1990 Sep; 87(18):7324-8.
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  50. Mohimen A, Maitra TK, Pillai S. The prediction of serum IgG levels by scanning densitometry. Indian J Pathol Microbiol. 1990 Jul; 33(3):266-9.
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  51. Cherayil BJ, Weiner SJ, Pillai S. The Mac-2 antigen is a galactose-specific lectin that binds IgE. J Exp Med. 1989 Dec 1; 170(6):1959-72.
    View in: PubMed
  52. Variyam EP, Gogate P, Hassan M, Costerton WJ, Pillai S, Ward H, Jalan K. Nondysenteric intestinal amebiasis. Colonic morphology and search for Entamoeba histolytica adherence and invasion. Dig Dis Sci. 1989 May; 34(5):732-40.
    View in: PubMed
  53. Pillai S, Baltimore D. The omega and iota surrogate immunoglobulin light chains. Curr Top Microbiol Immunol. 1988; 137:136-9.
    View in: PubMed
  54. Pillai S, Baltimore D. Myristoylation and the post-translational acquisition of hydrophobicity by the membrane immunoglobulin heavy-chain polypeptide in B lymphocytes. Proc Natl Acad Sci U S A. 1987 Nov; 84(21):7654-8.
    View in: PubMed
  55. Pillai S, Baltimore D. Formation of disulphide-linked mu 2 omega 2 tetramers in pre-B cells by the 18K omega-immunoglobulin light chain. Nature. 1987 Sep 10-16; 329(6135):172-4.
    View in: PubMed
  56. Pillai S. Can we diagnose amoebiasis? Gastroenterology. 1983 Feb; 84(2):445-6.
    View in: PubMed
  57. Pillai S, Mohimen A, Mehra S. A radioimmunoprecipitation polyethylene glycol assay for circulating Entamoeba histolytica antigens. J Immunol Methods. 1982 Dec 17; 55(2):273-6.
    View in: PubMed
  58. Pillai S, Mohimen A. A solid-phase sandwich radioimmunoassay for Entamoeba histolytica proteins and the detection of circulating antigens in amoebiasis. Gastroenterology. 1982 Dec; 83(6):1210-6.
    View in: PubMed
  59. Pillai S. Can multiple low-density immunoadsorbents and 'negative' distance matrices help predict the three-dimensional structure of any globular protein? Biochem J. 1981 Oct 1; 199(1):277-80.
    View in: PubMed
  60. Pillai S. Chemical cross-linking of a dimeric protein on a modified lectin matrix. A general probe for the chemical topology of oligomeric glycoproteins. Biochem J. 1981 Mar 1; 193(3):825-8.
    View in: PubMed
  61. Pillai S, Mohimen A, Kanjilal A. A polyethylene glycol-based radioimmunoassay for gastrin. J Immunol Methods. 1980; 39(1-2):181-4.
    View in: PubMed
  62. Pillai S, Bachhawat BK. Affinity immobilisation and "negative" crosslinking: a probe for tertiary and quaternary protein structure. J Mol Biol. 1979 Jul 15; 131(4):877-81.
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  63. Pillai S, Bachhawat BK. Stoichiometric enzyme--peptide conjugation of an affinity matrix. FEBS Lett. 1979 May 15; 101(2):301-4.
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  64. Pillai S, Bachhawat BK. Monoconjugate enzyme linked immunoassay. FEBS Lett. 1978 Jun 1; 90(1):51-3.
    View in: PubMed
  65. Pillai S, Bachhawat BK. Protein-protein conjugation on a lectin matrix. Biochem Biophys Res Commun. 1977 Mar 21; 75(2):240-5.
    View in: PubMed
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