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Raymond H Mak, M.D.

TitleAssistant Professor of Radiation Oncology
InstitutionBrigham and Women's Hospital
DepartmentRadiation Oncology
AddressBrigham and Womens Hospital
Radiation Oncology, ASB1 - L2
75 Francis St
Boston MA 02115
Phone617/632-7325
Fax617/632-2742

 Mentoring 
 current student opportunities
Available: 08/01/12, Expires: 07/30/14

Ongoing clinical research projects involve evaluating genetic predictors of tumor response to radiation (e.g. tumor mutations in EGFR and KRAS genes) and germline single nucleotide polymorphisms that predict risk of radiation toxicity. Additional projects incorporate functional imaging (e.g. MRI perfusion scans) to identify radiation-induced injury and tumor response. Specific sub-projects in the frame work of these studies would be identified in discussion with interested students and could entail either more short term or more long term studies.

 completed student projects
Genetic and Clinical Predictors of Radiation Esophagitis in Lung Cancer Treatment
Summer, 06/17/13 - 08/16/13

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Velazquez ER, Parmar C, Jermoumi M, Mak RH, van Baardwijk A, Fennessy FM, Lewis JH, De Ruysscher D, Kikinis R, Lambin P, Aerts HJ. Volumetric CT-based segmentation of NSCLC using 3D-Slicer. Sci Rep. 2013; 3:3529.
    View in: PubMed
  2. Williams CL, Mishra P, Seco J, James SS, Mak RH, Berbeco RI, Lewis JH. A mass-conserving 4D XCAT phantom for dose calculation and accumulation. Med Phys. 2013 Jul; 40(7):071728.
    View in: PubMed
  3. Mishra P, Li R, James SS, Mak RH, Williams CL, Yue Y, Berbeco RI, Lewis JH. Evaluation of 3D fluoroscopic image generation from a single planar treatment image on patient data with a modified XCAT phantom. Phys Med Biol. 2013 Feb 21; 58(4):841-58.
    View in: PubMed
  4. Mak RH, Alexander BM, Asomaning K, Heist RS, Liu CY, Su L, Zhai R, Ancukiewicz M, Napolitano B, Niemierko A, Willers H, Choi NC, Christiani DC. A single-nucleotide polymorphism in the methylene tetrahydrofolate reductase (MTHFR) gene is associated with risk of radiation pneumonitis in lung cancer patients treated with thoracic radiation therapy. Cancer. 2012 Jul 15; 118(14):3654-65.
    View in: PubMed
  5. Alexander BM, Wang XZ, Niemierko A, Weaver DT, Mak RH, Roof KS, Fidias P, Wain J, Choi NC. DNA repair biomarkers predict response to neoadjuvant chemoradiotherapy in esophageal cancer. Int J Radiat Oncol Biol Phys. 2012 May 1; 83(1):164-71.
    View in: PubMed
  6. Mak RH, Doran E, Muzikansky A, Kang J, Neal JW, Baldini EH, Choi NC, Willers H, Jackman DM, Sequist LV. Outcomes after combined modality therapy for EGFR-mutant and wild-type locally advanced NSCLC. Oncologist. 2011; 16(6):886-95.
    View in: PubMed
  7. Mak RH, Digumarthy SR, Muzikansky A, Engelman JA, Shepard JA, Choi NC, Sequist LV. Role of 18F-fluorodeoxyglucose positron emission tomography in predicting epidermal growth factor receptor mutations in non-small cell lung cancer. Oncologist. 2011; 16(3):319-26.
    View in: PubMed
  8. Novershtern N, Subramanian A, Lawton LN, Mak RH, Haining WN, McConkey ME, Habib N, Yosef N, Chang CY, Shay T, Frampton GM, Drake AC, Leskov I, Nilsson B, Preffer F, Dombkowski D, Evans JW, Liefeld T, Smutko JS, Chen J, Friedman N, Young RA, Golub TR, Regev A, Ebert BL. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell. 2011 Jan 21; 144(2):296-309.
    View in: PubMed
  9. Mak RH, McCarthy EP, Das P, Hong TS, Mamon HJ, Hoffman KE. Adoption of preoperative radiation therapy for rectal cancer from 2000 to 2006: a Surveillance, Epidemiology, and End Results Patterns-of-Care Study. Int J Radiat Oncol Biol Phys. 2011 Jul 15; 80(4):978-84.
    View in: PubMed
  10. Mak RH, Halasz LM, Tanaka CK, Ancukiewicz M, Schultz DJ, Russell AH, Viswanathan AN. Outcomes after radiation therapy with concurrent weekly platinum-based chemotherapy or every-3-4-week 5-fluorouracil-containing regimens for squamous cell carcinoma of the vulva. Gynecol Oncol. 2011 Jan; 120(1):101-7.
    View in: PubMed
  11. Mak KS, Lee LK, Mak RH, Wang S, Pile-Spellman J, Abrahm JL, Prigerson HG, Balboni TA. Incidence and treatment patterns in hospitalizations for malignant spinal cord compression in the United States, 1998-2006. Int J Radiat Oncol Biol Phys. 2011 Jul 1; 80(3):824-31.
    View in: PubMed
  12. Bradner JE, Mak R, Tanguturi SK, Mazitschek R, Haggarty SJ, Ross K, Chang CY, Bosco J, West N, Morse E, Lin K, Shen JP, Kwiatkowski NP, Gheldof N, Dekker J, DeAngelo DJ, Carr SA, Schreiber SL, Golub TR, Ebert BL. Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12617-22.
    View in: PubMed
  13. Mak RH, Mamon HJ, Ryan DP, Miyamoto DT, Ancukiewicz M, Kobayashi WK, Willett CG, Choi NC, Blaszkowsky LS, Hong TS. Toxicity and outcomes after chemoradiation for esophageal cancer in patients age 75 or older. Dis Esophagus. 2010 May; 23(4):316-23.
    View in: PubMed
  14. Mak RH, Zietman AL, Heney NM, Kaufman DS, Shipley WU. Bladder preservation: optimizing radiotherapy and integrated treatment strategies. BJU Int. 2008 Nov; 102(9 Pt B):1345-53.
    View in: PubMed
  15. Haining WN, Ebert BL, Subrmanian A, Wherry EJ, Eichbaum Q, Evans JW, Mak R, Rivoli S, Pretz J, Angelosanto J, Smutko JS, Walker BD, Kaech SM, Ahmed R, Nadler LM, Golub TR. Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. J Immunol. 2008 Aug 1; 181(3):1859-68.
    View in: PubMed
  16. Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, Golub TR. MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev Cell. 2008 Jun; 14(6):843-53.
    View in: PubMed
  17. Ebert BL, Galili N, Tamayo P, Bosco J, Mak R, Pretz J, Tanguturi S, Ladd-Acosta C, Stone R, Golub TR, Raza A. An erythroid differentiation signature predicts response to lenalidomide in myelodysplastic syndrome. PLoS Med. 2008 Feb; 5(2):e35.
    View in: PubMed
  18. Lu J, Getz G, Miska EA, Alvarez-Saavedra E, Lamb J, Peck D, Sweet-Cordero A, Ebert BL, Mak RH, Ferrando AA, Downing JR, Jacks T, Horvitz HR, Golub TR. MicroRNA expression profiles classify human cancers. Nature. 2005 Jun 9; 435(7043):834-8.
    View in: PubMed
  19. Ebert BL, Lee MM, Pretz JL, Subramanian A, Mak R, Golub TR, Sieff CA. An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray. Blood. 2005 Jun 15; 105(12):4620-6.
    View in: PubMed
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