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Randy Lyanne Gollub, M.D., PH.D.

TitleAssociate Professor of Psychiatry
InstitutionMassachusetts General Hospital
DepartmentPsychiatry
AddressMGH - Psychiatric Neuroimaging
Bldg 120, Suite 101D
2nd Avenue
Charlestown MA 02129
Phone617/724-9602
Fax617/643-7340
Other Positions
TitleMember of the Affiliated Faculty of the Harvard-MIT Division of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology


 Overview 
 overview
The work in my laboratory falls into two main domains:
1) Translational interface between the biomedical imaging technologies (particularly the development, calibration and validation of MRI acquisition and analysis methods) and their application to clinical neuroscience.
and
2) Study of the neural representation of acute and chronic pain and its modulation by acupuncture and placebo/expectation.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Kong J, Jensen K, Loiotile R, Cheetham A, Wey HY, Tan Y, Rosen B, Smoller JW, Kaptchuk TJ, Gollub RL. Functional connectivity of the frontoparietal network predicts cognitive modulation of pain. Pain. 2013 Mar; 154(3):459-67.
    View in: PubMed
  2. Loggia ML, Kim J, Gollub RL, Vangel MG, Kirsch I, Kong J, Wasan AD, Napadow V. Default mode network connectivity encodes clinical pain: An arterial spin labeling study. Pain. 2013 Jan; 154(1):24-33.
    View in: PubMed
  3. Jensen KB, Kaptchuk TJ, Kirsch I, Raicek J, Lindstrom KM, Berna C, Gollub RL, Ingvar M, Kong J. Nonconscious activation of placebo and nocebo pain responses. Proc Natl Acad Sci U S A. 2012 Sep 25; 109(39):15959-64.
    View in: PubMed
  4. Loggia ML, Edwards RR, Kim J, Vangel MG, Wasan AD, Gollub RL, Harris RE, Park K, Napadow V. Disentangling linear and nonlinear brain responses to evoked deep tissue pain. Pain. 2012 Oct; 153(10):2140-51.
    View in: PubMed
  5. Turner JA, Calhoun VD, Michael A, van Erp TG, Ehrlich S, Segall JM, Gollub RL, Csernansky J, Potkin SG, Ho BC, Bustillo J, Schulz SC, Wang L. Heritability of multivariate gray matter measures in schizophrenia. Twin Res Hum Genet. 2012 Jun; 15(3):324-35.
    View in: PubMed
  6. Jensen KB, Loitoile R, Kosek E, Petzke F, Carville S, Fransson P, Marcus H, Williams SC, Choy E, Mainguy Y, Vitton O, Gracely RH, Gollub R, Ingvar M, Kong J. Patients with fibromyalgia display less functional connectivity in the brain's pain inhibitory network. Mol Pain. 2012; 8:32.
    View in: PubMed
  7. Jensen KB, Berna C, Loggia ML, Wasan AD, Edwards RR, Gollub RL. The use of functional neuroimaging to evaluate psychological and other non-pharmacological treatments for clinical pain. Neurosci Lett. 2012 Jun 29; 520(2):156-64.
    View in: PubMed
  8. Cullen KR, Wallace S, Magnotta VA, Bockholt J, Ehrlich S, Gollub RL, Manoach DS, Ho BC, Clark VP, Lauriello J, Bustillo JR, Schulz SC, Andreasen NC, Calhoun VD, Lim KO, White T. Cigarette smoking and white matter microstructure in schizophrenia. Psychiatry Res. 2012 Feb 28; 201(2):152-8.
    View in: PubMed
  9. Linnman C, Beucke JC, Jensen KB, Gollub RL, Kong J. Sex similarities and differences in pain-related periaqueductal gray connectivity. Pain. 2012 Feb; 153(2):444-54.
    View in: PubMed
  10. Karageorgiou E, Schulz SC, Gollub RL, Andreasen NC, Ho BC, Lauriello J, Calhoun VD, Bockholt HJ, Sponheim SR, Georgopoulos AP. Neuropsychological testing and structural magnetic resonance imaging as diagnostic biomarkers early in the course of schizophrenia and related psychoses. Neuroinformatics. 2011 Dec; 9(4):321-33.
    View in: PubMed
  11. Loggia ML, Jensen K, Gollub RL, Wasan AD, Edwards RR, Kong J. The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli. PLoS One. 2011; 6(11):e27764.
    View in: PubMed
  12. Yendiki A, Panneck P, Srinivasan P, Stevens A, Zöllei L, Augustinack J, Wang R, Salat D, Ehrlich S, Behrens T, Jbabdi S, Gollub R, Fischl B. Automated probabilistic reconstruction of white-matter pathways in health and disease using an atlas of the underlying anatomy. Front Neuroinform. 2011; 5:23.
    View in: PubMed
  13. Wasan AD, Loggia ML, Chen LQ, Napadow V, Kong J, Gollub RL. Neural correlates of chronic low back pain measured by arterial spin labeling. Anesthesiology. 2011 Aug; 115(2):364-74.
    View in: PubMed
  14. Brauns S, Gollub RL, Roffman JL, Yendiki A, Ho BC, Wassink TH, Heinz A, Ehrlich S. DISC1 is associated with cortical thickness and neural efficiency. Neuroimage. 2011 Aug 15; 57(4):1591-600.
    View in: PubMed
  15. Carter CS, Barch DM, Bullmore E, Breiling J, Buchanan RW, Butler P, Cohen JD, Geyer M, Gollub R, Green MF, Jaeger J, Krystal JH, Moore H, Nuechterlein K, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T. Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: developing imaging biomarkers to enhance treatment development for schizophrenia and related disorders. Biol Psychiatry. 2011 Jul 1; 70(1):7-12.
    View in: PubMed
  16. Ehrlich S, Brauns S, Yendiki A, Ho BC, Calhoun V, Schulz SC, Gollub RL, Sponheim SR. Associations of cortical thickness and cognition in patients with schizophrenia and healthy controls. Schizophr Bull. 2012 Sep; 38(5):1050-62.
    View in: PubMed
  17. Gollub RL, Kong J. For placebo effects in medicine, seeing is believing. Sci Transl Med. 2011 Feb 16; 3(70):70ps5.
    View in: PubMed
  18. Abbott C, Juárez M, White T, Gollub RL, Pearlson GD, Bustillo J, Lauriello J, Ho B, Bockholt HJ, Clark VP, Magnotta V, Calhoun VD. Antipsychotic dose and diminished neural modulation: a multi-site fMRI study. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Mar 30; 35(2):473-82.
    View in: PubMed
  19. Gollub RL, Turner DA. Neuroinformatics in clinical and translational medicine--novel approaches. Neuroinformatics. 2010 Dec; 8(4):207-12.
    View in: PubMed
  20. Zyloney CE, Jensen K, Polich G, Loiotile RE, Cheetham A, LaViolette PS, Tu P, Kaptchuk TJ, Gollub RL, Kong J. Imaging the functional connectivity of the Periaqueductal Gray during genuine and sham electroacupuncture treatment. Mol Pain. 2010; 6:80.
    View in: PubMed
  21. Yendiki A, Greve DN, Wallace S, Vangel M, Bockholt J, Mueller BA, Magnotta V, Andreasen N, Manoach DS, Gollub RL. Multi-site characterization of an fMRI working memory paradigm: reliability of activation indices. Neuroimage. 2010 Oct 15; 53(1):119-31.
    View in: PubMed
  22. Wasan AD, Kong J, Pham LD, Kaptchuk TJ, Edwards R, Gollub RL. The impact of placebo, psychopathology, and expectations on the response to acupuncture needling in patients with chronic low back pain. J Pain. 2010 Jun; 11(6):555-63.
    View in: PubMed
  23. Ehrlich S, Morrow EM, Roffman JL, Wallace SR, Naylor M, Bockholt HJ, Lundquist A, Yendiki A, Ho BC, White T, Manoach DS, Clark VP, Calhoun VD, Gollub RL, Holt DJ. The COMT Val108/158Met polymorphism and medial temporal lobe volumetry in patients with schizophrenia and healthy adults. Neuroimage. 2010 Nov 15; 53(3):992-1000.
    View in: PubMed
  24. Kong J, Loggia ML, Zyloney C, Tu P, Laviolette P, Gollub RL. Exploring the brain in pain: activations, deactivations and their relation. Pain. 2010 Feb; 148(2):257-67.
    View in: PubMed
  25. Kim DI, Manoach DS, Mathalon DH, Turner JA, Mannell M, Brown GG, Ford JM, Gollub RL, White T, Wible C, Belger A, Bockholt HJ, Clark VP, Lauriello J, O'Leary D, Mueller BA, Lim KO, Andreasen N, Potkin SG, Calhoun VD. Dysregulation of working memory and default-mode networks in schizophrenia using independent component analysis, an fBIRN and MCIC study. Hum Brain Mapp. 2009 Nov; 30(11):3795-811.
    View in: PubMed
  26. White T, Magnotta VA, Bockholt HJ, Williams S, Wallace S, Ehrlich S, Mueller BA, Ho BC, Jung RE, Clark VP, Lauriello J, Bustillo JR, Schulz SC, Gollub RL, Andreasen NC, Calhoun VD, Lim KO. Global white matter abnormalities in schizophrenia: a multisite diffusion tensor imaging study. Schizophr Bull. 2011 Jan; 37(1):222-32.
    View in: PubMed
  27. Michael AM, Baum SA, White T, Demirci O, Andreasen NC, Segall JM, Jung RE, Pearlson G, Clark VP, Gollub RL, Schulz SC, Roffman JL, Lim KO, Ho BC, Bockholt HJ, Calhoun VD. Does function follow form?: methods to fuse structural and functional brain images show decreased linkage in schizophrenia. Neuroimage. 2010 Feb 1; 49(3):2626-37.
    View in: PubMed
  28. Kong J, Kaptchuk TJ, Polich G, Kirsch I, Vangel M, Zyloney C, Rosen B, Gollub RL. An fMRI study on the interaction and dissociation between expectation of pain relief and acupuncture treatment. Neuroimage. 2009 Sep; 47(3):1066-76.
    View in: PubMed
  29. Jovicich J, Czanner S, Han X, Salat D, van der Kouwe A, Quinn B, Pacheco J, Albert M, Killiany R, Blacker D, Maguire P, Rosas D, Makris N, Gollub R, Dale A, Dickerson BC, Fischl B. MRI-derived measurements of human subcortical, ventricular and intracranial brain volumes: Reliability effects of scan sessions, acquisition sequences, data analyses, scanner upgrade, scanner vendors and field strengths. Neuroimage. 2009 May 15; 46(1):177-92.
    View in: PubMed
  30. Kim DI, Mathalon DH, Ford JM, Mannell M, Turner JA, Brown GG, Belger A, Gollub R, Lauriello J, Wible C, O'Leary D, Lim K, Toga A, Potkin SG, Birn F, Calhoun VD. Auditory oddball deficits in schizophrenia: an independent component analysis of the fMRI multisite function BIRN study. Schizophr Bull. 2009 Jan; 35(1):67-81.
    View in: PubMed
  31. Kong J, Kaptchuk TJ, Webb JM, Kong JT, Sasaki Y, Polich GR, Vangel MG, Kwong K, Rosen B, Gollub RL. Functional neuroanatomical investigation of vision-related acupuncture point specificity--a multisession fMRI study. Hum Brain Mapp. 2009 Jan; 30(1):38-46.
    View in: PubMed
  32. Kong J, Kaptchuk TJ, Polich G, Kirsch I, Vangel M, Zyloney C, Rosen B, Gollub R. Expectancy and treatment interactions: a dissociation between acupuncture analgesia and expectancy evoked placebo analgesia. Neuroimage. 2009 Apr 15; 45(3):940-9.
    View in: PubMed
  33. Kong J, Gollub RL, Polich G, Kirsch I, Laviolette P, Vangel M, Rosen B, Kaptchuk TJ. A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect. J Neurosci. 2008 Dec 3; 28(49):13354-62.
    View in: PubMed
  34. Potkin SG, Turner JA, Brown GG, McCarthy G, Greve DN, Glover GH, Manoach DS, Belger A, Diaz M, Wible CG, Ford JM, Mathalon DH, Gollub R, Lauriello J, O'Leary D, van Erp TG, Toga AW, Preda A, Lim KO. Working memory and DLPFC inefficiency in schizophrenia: the FBIRN study. Schizophr Bull. 2009 Jan; 35(1):19-31.
    View in: PubMed
  35. Brown GG, McCarthy G, Bischoff-Grethe A, Ozyurt B, Greve D, Potkin SG, Turner JA, Notestine R, Calhoun VD, Ford JM, Mathalon D, Manoach DS, Gadde S, Glover GH, Wible CG, Belger A, Gollub RL, Lauriello J, O'Leary D, Lim KO. Brain-performance correlates of working memory retrieval in schizophrenia: a cognitive modeling approach. Schizophr Bull. 2009 Jan; 35(1):32-46.
    View in: PubMed
  36. Segall JM, Turner JA, van Erp TG, White T, Bockholt HJ, Gollub RL, Ho BC, Magnotta V, Jung RE, McCarley RW, Schulz SC, Lauriello J, Clark VP, Voyvodic JT, Diaz MT, Calhoun VD. Voxel-based morphometric multisite collaborative study on schizophrenia. Schizophr Bull. 2009 Jan; 35(1):82-95.
    View in: PubMed
  37. Roffman JL, Gollub RL, Calhoun VD, Wassink TH, Weiss AP, Ho BC, White T, Clark VP, Fries J, Andreasen NC, Goff DC, Manoach DS. MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17573-8.
    View in: PubMed
  38. Leyba L, Mayer AR, Gollub RL, Andreasen NC, Clark VP. Smoking status as a potential confound in the BOLD response of patients with schizophrenia. Schizophr Res. 2008 Sep; 104(1-3):79-84.
    View in: PubMed
  39. Friedman L, Stern H, Brown GG, Mathalon DH, Turner J, Glover GH, Gollub RL, Lauriello J, Lim KO, Cannon T, Greve DN, Bockholt HJ, Belger A, Mueller B, Doty MJ, He J, Wells W, Smyth P, Pieper S, Kim S, Kubicki M, Vangel M, Potkin SG. Test-retest and between-site reliability in a multicenter fMRI study. Hum Brain Mapp. 2008 Aug; 29(8):958-72.
    View in: PubMed
  40. Magnotta VA, Adix ML, Caprahan A, Lim K, Gollub R, Andreasen NC. Investigating connectivity between the cerebellum and thalamus in schizophrenia using diffusion tensor tractography: a pilot study. Psychiatry Res. 2008 Aug 30; 163(3):193-200.
    View in: PubMed
  41. Dougherty DD, Kong J, Webb M, Bonab AA, Fischman AJ, Gollub RL. A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia. Behav Brain Res. 2008 Nov 3; 193(1):63-8.
    View in: PubMed
  42. Pujol S, Kikinis R, Gollub R. Lowering the barriers inherent in translating advances in neuroimage analysis to clinical research applications. Acad Radiol. 2008 Jan; 15(1):114-8.
    View in: PubMed
  43. Kong J, Gollub R, Huang T, Polich G, Napadow V, Hui K, Vangel M, Rosen B, Kaptchuk TJ. Acupuncture de qi, from qualitative history to quantitative measurement. J Altern Complement Med. 2007 Dec; 13(10):1059-70.
    View in: PubMed
  44. Fennema-Notestine C, Gamst AC, Quinn BT, Pacheco J, Jernigan TL, Thal L, Buckner R, Killiany R, Blacker D, Dale AM, Fischl B, Dickerson B, Gollub RL. Feasibility of multi-site clinical structural neuroimaging studies of aging using legacy data. Neuroinformatics. 2007; 5(4):235-45.
    View in: PubMed
  45. Wakana S, Caprihan A, Panzenboeck MM, Fallon JH, Perry M, Gollub RL, Hua K, Zhang J, Jiang H, Dubey P, Blitz A, van Zijl P, Mori S. Reproducibility of quantitative tractography methods applied to cerebral white matter. Neuroimage. 2007 Jul 1; 36(3):630-44.
    View in: PubMed
  46. Kong J, Kaptchuk TJ, Polich G, Kirsch I, Gollub RL. Placebo analgesia: findings from brain imaging studies and emerging hypotheses. Rev Neurosci. 2007; 18(3-4):173-90.
    View in: PubMed
  47. Murphy SN, Mendis ME, Grethe JS, Gollub RL, Kennedy D, Rosen BR. A web portal that enables collaborative use of advanced medical image processing and informatics tools through the Biomedical Informatics Research Network (BIRN). AMIA Annu Symp Proc. 2006; 579-83.
    View in: PubMed
  48. Jovicich J, Czanner S, Greve D, Haley E, van der Kouwe A, Gollub R, Kennedy D, Schmitt F, Brown G, Macfall J, Fischl B, Dale A. Reliability in multi-site structural MRI studies: effects of gradient non-linearity correction on phantom and human data. Neuroimage. 2006 Apr 1; 30(2):436-43.
    View in: PubMed
  49. Kong J, Wang C, Kwong K, Vangel M, Chua E, Gollub R. The neural substrate of arithmetic operations and procedure complexity. Brain Res Cogn Brain Res. 2005 Mar; 22(3):397-405.
    View in: PubMed
  50. Lazar SW, Bush G, Gollub RL, Fricchione GL, Khalsa G, Benson H. Functional brain mapping of the relaxation response and meditation. Neuroreport. 2000 May 15; 11(7):1581-5.
    View in: PubMed
  51. Breiter HC, Gollub RL, Weisskoff RM, Kennedy DN, Makris N, Berke JD, Goodman JM, Kantor HL, Gastfriend DR, Riorden JP, Mathew RT, Rosen BR, Hyman SE. Acute effects of cocaine on human brain activity and emotion. Neuron. 1997 Sep; 19(3):591-611.
    View in: PubMed
  52. Gollub RL, Rauch SL. Neuroimaging: issues of design, resolution, and interpretation. Harv Rev Psychiatry. 1996 Jan-Feb; 3(5):285-9.
    View in: PubMed
  53. Clark D, Gollub R, Green WF, Harvey N, Murphy SJ, Samet JM. Asthma in Jemez Pueblo schoolchildren. Am J Respir Crit Care Med. 1995 May; 151(5):1625-7.
    View in: PubMed
  54. Gollub RL, Hyman SE. G proteins and second messengers in psychiatry. Harv Rev Psychiatry. 1995 May-Jun; 3(1):41-4.
    View in: PubMed
  55. Hyman SE, Gollub RL. More serotonin: not as simple as it seems. Harv Rev Psychiatry. 1994 Nov-Dec; 2(4):222-4.
    View in: PubMed
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