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James William Rocco, M.D.,Ph.D.

TitleDaniel Miller Associate Professor of Otology and Laryngology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOtology and Laryngology
AddressMassachusetts Eye & Ear Infrm
Otololaryngology-Head & Neck Surgery
243 Charles St
Boston MA 02114
Phone617/726-5251
Fax617/726-8623

 Mentoring 
 completed student projects
Serum Methylation of Tumor Suppressor Genes in Oropharyngeal HNSCC
Summer, 06/11/12 - 08/17/12

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bonilla-Velez J, Mroz EA, Hammon RJ, Rocco JW. Impact of human papillomavirus on oropharyngeal cancer biology and response to therapy: implications for treatment. Otolaryngol Clin North Am. 2013 Aug; 46(4):521-43.
    View in: PubMed
  2. Mroz EA, Tward AD, Pickering CR, Myers JN, Ferris RL, Rocco JW. High intratumor genetic heterogeneity is related to worse outcome in patients with head and neck squamous cell carcinoma. Cancer. 2013 Aug 15; 119(16):3034-42.
    View in: PubMed
  3. Puram SV, Hasserjian RP, Faquin WC, Lin HW, Rocco JW. Castleman disease presenting in the neck: Report of a case and review of the literature. Am J Otolaryngol. 2013 May-Jun; 34(3):239-44.
    View in: PubMed
  4. Mroz EA, Rocco JW. MATH, a novel measure of intratumor genetic heterogeneity, is high in poor-outcome classes of head and neck squamous cell carcinoma. Oral Oncol. 2013 Mar; 49(3):211-5.
    View in: PubMed
  5. Mroz EA, Rocco JW. Gene expression analysis as a tool in early-stage oral cancer management. J Clin Oncol. 2012 Nov 20; 30(33):4053-5.
    View in: PubMed
  6. Kakarala K, Emerick KS, Lin DT, Rocco JW, Deschler DG. Free flap reconstruction in 1999 and 2009: changing case characteristics and outcomes. Laryngoscope. 2012 Oct; 122(10):2160-3.
    View in: PubMed
  7. Mroz EA, Forastiere AA, Rocco JW. Implications of the oropharyngeal cancer epidemic. J Clin Oncol. 2011 Nov 10; 29(32):4222-3.
    View in: PubMed
  8. Lee LN, Hasserjian RP, Faquin WC, Takvorian RW, Rocco JW. Pathology quiz case 1. Diffuse large B-cell lymphoma (DLBCL) of the thyroid. Arch Otolaryngol Head Neck Surg. 2011 Aug; 137(8):829; author reply 832-3.
    View in: PubMed
  9. Nichols AC, Kneuertz PJ, Deschler DG, Lin DT, Emerick KS, Clark JR, Busse PW, Rocco JW. Surgical salvage of the oropharynx after failure of organ-sparing therapy. Head Neck. 2011 Apr; 33(4):516-24.
    View in: PubMed
  10. Hammon RJ, Lin HW, Sadow PM, Lin DT, Rocco JW. Pathology quiz case 1. Angiosarcoma. Arch Otolaryngol Head Neck Surg. 2011 Feb; 137(2):198, 200-1.
    View in: PubMed
  11. Ory B, Ramsey MR, Wilson C, Vadysirisack DD, Forster N, Rocco JW, Rothenberg SM, Ellisen LW. A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma. J Clin Invest. 2011 Feb; 121(2):809-20.
    View in: PubMed
  12. Divi V, Lin DT, Emerick K, Rocco J, Deschler DG. Primary TEP placement in patients with laryngopharyngeal free tissue reconstruction and salivary bypass tube placement. Otolaryngol Head Neck Surg. 2011 Mar; 144(3):474-6.
    View in: PubMed
  13. Silver AL, Farkash EA, Pitman MB, Rocco JW. Rosai-Dorfman disease presenting in the oropharynx. Head Neck. 2011 Nov; 33(11):1660-3.
    View in: PubMed
  14. Nichols AC, Finkelstein DM, Faquin WC, Westra WH, Mroz EA, Kneuertz P, Begum S, Michaud WA, Busse PM, Clark JR, Rocco JW. Bcl2 and human papilloma virus 16 as predictors of outcome following concurrent chemoradiation for advanced oropharyngeal cancer. Clin Cancer Res. 2010 Apr 1; 16(7):2138-46.
    View in: PubMed
  15. Rothenberg SM, Mohapatra G, Rivera MN, Winokur D, Greninger P, Nitta M, Sadow PM, Sooriyakumar G, Brannigan BW, Ulman MJ, Perera RM, Wang R, Tam A, Ma XJ, Erlander M, Sgroi DC, Rocco JW, Lingen MW, Cohen EE, Louis DN, Settleman J, Haber DA. A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers. Cancer Res. 2010 Mar 15; 70(6):2158-64.
    View in: PubMed
  16. Mroz EA, Rocco JW. Functional p53 status as a biomarker for chemotherapy response in oral-cavity cancer. J Clin Oncol. 2010 Feb 10; 28(5):715-7.
    View in: PubMed
  17. Deschler DG, Bunting GW, Lin DT, Emerick K, Rocco J. Evaluation of voice prosthesis placement at the time of primary tracheoesophageal puncture with total laryngectomy. Laryngoscope. 2009 Jul; 119(7):1353-7.
    View in: PubMed
  18. Leuin SC, Faquin WC, Pilch BZ, Rocco JW. Pathology quiz case 2. Sarcoidosis. Arch Otolaryngol Head Neck Surg. 2009 Jun; 135(6):617, 619-20.
    View in: PubMed
  19. Michaud WA, Nichols AC, Mroz EA, Faquin WC, Clark JR, Begum S, Westra WH, Wada H, Busse PM, Ellisen LW, Rocco JW. Bcl-2 blocks cisplatin-induced apoptosis and predicts poor outcome following chemoradiation treatment in advanced oropharyngeal squamous cell carcinoma. Clin Cancer Res. 2009 Mar 1; 15(5):1645-54.
    View in: PubMed
  20. Nichols AC, Faquin WC, Westra WH, Mroz EA, Begum S, Clark JR, Rocco JW. HPV-16 infection predicts treatment outcome in oropharyngeal squamous cell carcinoma. Otolaryngol Head Neck Surg. 2009 Feb; 140(2):228-34.
    View in: PubMed
  21. Mroz EA, Baird AH, Michaud WA, Rocco JW. COOH-terminal binding protein regulates expression of the p16INK4A tumor suppressor and senescence in primary human cells. Cancer Res. 2008 Aug 1; 68(15):6049-53.
    View in: PubMed
  22. Mroz EA, Rocco JW. RNA interference: natural, experimental, and clinical roles in cancer biology. Head Neck. 2006 Dec; 28(12):1132-41.
    View in: PubMed
  23. Morris EJ, Michaud WA, Ji JY, Moon NS, Rocco JW, Dyson NJ. Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. PLoS Genet. 2006 Nov 17; 2(11):e196.
    View in: PubMed
  24. DeYoung MP, Johannessen CM, Leong CO, Faquin W, Rocco JW, Ellisen LW. Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma. Cancer Res. 2006 Oct 1; 66(19):9362-8.
    View in: PubMed
  25. Rocco JW, Ellisen LW. p63 and p73: life and death in squamous cell carcinoma. Cell Cycle. 2006 May; 5(9):936-40.
    View in: PubMed
  26. Rocco JW, Leong CO, Kuperwasser N, DeYoung MP, Ellisen LW. p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis. Cancer Cell. 2006 Jan; 9(1):45-56.
    View in: PubMed
  27. Emerick KS, Mehta A, Pilch BZ, Deschler DG, Busse PM, Rocco JW. Pathology quiz case 1. Adenocarcinoma with features of mucinous adenocarcinoma (MAC) and cystadenocarcinoma (CAC). Arch Otolaryngol Head Neck Surg. 2005 Dec; 131(12):1120, 1122-3.
    View in: PubMed
  28. Cohen EE, Lingen MW, Martin LE, Harris PL, Brannigan BW, Haserlat SM, Okimoto RA, Sgroi DC, Dahiya S, Muir B, Clark JR, Rocco JW, Vokes EE, Haber DA, Bell DW. Response of some head and neck cancers to epidermal growth factor receptor tyrosine kinase inhibitors may be linked to mutation of ERBB2 rather than EGFR. Clin Cancer Res. 2005 Nov 15; 11(22):8105-8.
    View in: PubMed
  29. Amrein PC, Clark JR, Supko JG, Fabian RL, Wang CC, Colevas AD, Posner MR, Deschler DG, Rocco JW, Finkelstein DM, McIntyre JF. Phase I trial and pharmacokinetics of escalating doses of paclitaxel and concurrent hyperfractionated radiotherapy with or without amifostine in patients with advanced head and neck carcinoma. Cancer. 2005 Oct 1; 104(7):1418-27.
    View in: PubMed
  30. Varvares MA, Lin D, Hadlock T, Azzizadeh B, Gliklich R, Rounds M, Rocco J, Deschler DG, Fabian R, Cheney ML. Success of multiple, sequential, free tissue transfers to the head and neck. Laryngoscope. 2005 Jan; 115(1):101-4.
    View in: PubMed
  31. Shin JJ, Katayama T, Michaud WA, Rocco JW. Short hairpin RNA system to inhibit human p16 in squamous cell carcinoma. Arch Otolaryngol Head Neck Surg. 2004 Jan; 130(1):68-73.
    View in: PubMed
  32. Ung F, Rocco JW, Deschler DG. Temporary intraoperative external fixation in mandibular reconstruction. Laryngoscope. 2002 Sep; 112(9):1569-73.
    View in: PubMed
  33. Rocco JW, Sidransky D. p16(MTS-1/CDKN2/INK4a) in cancer progression. Exp Cell Res. 2001 Mar 10; 264(1):42-55.
    View in: PubMed
  34. Rocco JW, Li D, Liggett WH, Duan L, Saunders JK, Sidransky D, O'Malley BW. p16INK4A adenovirus-mediated gene therapy for human head and neck squamous cell cancer. Clin Cancer Res. 1998 Jul; 4(7):1697-704.
    View in: PubMed
  35. Blaugrund JE, Rocco JW, Niparko JK. Imaging quiz case 2. Complex temporal bone fracture. Arch Otolaryngol Head Neck Surg. 1997 Nov; 123(11):1237, 1239-40.
    View in: PubMed
  36. Liggett WH, Sewell DA, Rocco J, Ahrendt SA, Koch W, Sidransky D. p16 and p16 beta are potent growth suppressors of head and neck squamous carcinoma cells in vitro. Cancer Res. 1996 Sep 15; 56(18):4119-23.
    View in: PubMed
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