 Liangcai Gu, PH.D.
| Title | Research Fellow in Genetics (INT) |
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| Institution | Harvard Medical School |
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| Department | Genetics |
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| Address | Harvard Medical School
Dept of Genetics, NRB 232
77 Avenue Louis Pasteur
Boston MA 02115
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| Phone | 617/432-5917 |
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| Fax | 617/432-6513 |
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 Biography | 2009 -
2012 | Jane Coffin Childs Postdoc Fellowship |
Overview In George Church laboratory, I am developing a novel barcoded protein array technology, which enables multiplexed assays of a billion protein molecules on a standard microscopic slide. It is based on in situ DNA sequencing and cell-free protein translation technologies.
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Gehret JJ, Gu L, Geders TW, Brown WC, Gerwick L, Gerwick WH, Sherman DH, Smith JL. Structure and activity of DmmA, a marine haloalkane dehalogenase. Protein Sci. 2012 Feb; 21(2):239-48.
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Busche A, Gottstein D, Hein C, Ripin N, Pader I, Tufar P, Eisman EB, Gu L, Walsh CT, Sherman DH, Löhr F, Güntert P, Dötsch V. Characterization of molecular interactions between ACP and halogenase domains in the Curacin A polyketide synthase. ACS Chem Biol. 2012 Feb 17; 7(2):378-86.
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Gehret JJ, Gu L, Gerwick WH, Wipf P, Sherman DH, Smith JL. Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase. J Biol Chem. 2011 Apr 22; 286(16):14445-54.
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Gu L, Eisman EB, Dutta S, Franzmann TM, Walter S, Gerwick WH, Skiniotis G, Sherman DH. Tandem acyl carrier proteins in the curacin biosynthetic pathway promote consecutive multienzyme reactions with a synergistic effect. Angew Chem Int Ed Engl. 2011 Mar 14; 50(12):2795-8.
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Khare D, Wang B, Gu L, Razelun J, Sherman DH, Gerwick WH, Håkansson K, Smith JL. Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14099-104.
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Gu L, Wang B, Kulkarni A, Gehret JJ, Lloyd KR, Gerwick L, Gerwick WH, Wipf P, Håkansson K, Smith JL, Sherman DH. Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. J Am Chem Soc. 2009 Nov 11; 131(44):16033-5.
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Gu L, Wang B, Kulkarni A, Geders TW, Grindberg RV, Gerwick L, Håkansson K, Wipf P, Smith JL, Gerwick WH, Sherman DH. Metamorphic enzyme assembly in polyketide diversification. Nature. 2009 Jun 4; 459(7247):731-5.
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Jones AC, Gu L, Sorrels CM, Sherman DH, Gerwick WH. New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Curr Opin Chem Biol. 2009 Apr; 13(2):216-23.
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Sharp K, Arthur KE, Gu L, Ross C, Harrison G, Gunasekera SP, Meickle T, Matthew S, Luesch H, Thacker RW, Sherman DH, Paul VJ. Phylogenetic and chemical diversity of three chemotypes of bloom-forming lyngbya species (Cyanobacteria: Oscillatoriales) from reefs of southeastern Florida. Appl Environ Microbiol. 2009 May; 75(9):2879-88.
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Gu L, Geders TW, Wang B, Gerwick WH, Håkansson K, Smith JL, Sherman DH. GNAT-like strategy for polyketide chain initiation. Science. 2007 Nov 9; 318(5852):970-4.
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Geders TW, Gu L, Mowers JC, Liu H, Gerwick WH, Håkansson K, Sherman DH, Smith JL. Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. J Biol Chem. 2007 Dec 7; 282(49):35954-63.
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Gu L, Jia J, Liu H, Håkansson K, Gerwick WH, Sherman DH. Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair. J Am Chem Soc. 2006 Jul 19; 128(28):9014-5.
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Fu X, Liu C, Liu Y, Feng X, Gu L, Chen X, Chang Z. Small heat shock protein Hsp16.3 modulates its chaperone activity by adjusting the rate of oligomeric dissociation. Biochem Biophys Res Commun. 2003 Oct 17; 310(2):412-20.
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Abulimiti A, Fu X, Gu L, Feng X, Chang Z. Mycobacterium tuberculosis Hsp16.3 nonamers are assembled and re-assembled via trimer and hexamer intermediates. J Mol Biol. 2003 Feb 28; 326(4):1013-23.
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Gu L, Abulimiti A, Li W, Chang Z. Monodisperse Hsp16.3 nonamer exhibits dynamic dissociation and reassociation, with the nonamer dissociation prerequisite for chaperone-like activity. J Mol Biol. 2002 May 31; 319(2):517-26.
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