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Jonathan Lee Tilly, PH.D.

TitleProfessor of Obstetrics, Gynecology and Reproductive Biology
InstitutionMassachusetts General Hospital
DepartmentObstetrics Gynecology & Repro. Bio.
AddressMassachusetts General Hospital
Vbk 137C-Gyn
55 Fruit St
Boston MA 02114
Phone617/724-2182
Fax617/726-7548

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Park ES, Woods DC, Tilly JL. Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling. Fertil Steril. 2013 Nov; 100(5):1468-1475.e2.
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  2. Imudia AN, Wang N, Tanaka Y, White YA, Woods DC, Tilly JL. Comparative gene expression profiling of adult mouse ovary-derived oogonial stem cells supports a distinct cellular identity. Fertil Steril. 2013 Nov; 100(5):1451-1458.e2.
    View in: PubMed
  3. Tilly JL, Sinclair DA. Germline energetics, aging, and female infertility. Cell Metab. 2013 Jun 4; 17(6):838-50.
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  4. Woods DC, Tilly JL. Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries. Nat Protoc. 2013 Apr 18; 8(5):966-88.
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  5. Woods DC, White YA, Niikura Y, Kiatpongsan S, Lee HJ, Tilly JL. Embryonic stem cell-derived granulosa cells participate in ovarian follicle formation in vitro and in vivo. Reprod Sci. 2013 May; 20(5):524-35.
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  6. Woods DC, Tilly JL. An evolutionary perspective on adult female germline stem cell function from flies to humans. Semin Reprod Med. 2013 Jan; 31(1):24-32.
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  7. Nehra D, Le HD, Fallon EM, Carlson SJ, Woods D, White YA, Pan AH, Guo L, Rodig SJ, Tilly JL, Rueda BR, Puder M. Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids. Aging Cell. 2012 Dec; 11(6):1046-54.
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  8. Woods DC, White YA, Tilly JL. Purification of oogonial stem cells from adult mouse and human ovaries: an assessment of the literature and a view toward the future. Reprod Sci. 2013 Jan; 20(1):7-15.
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  9. Woods DC, Telfer EE, Tilly JL. Oocyte family trees: old branches or new stems? PLoS Genet. 2012; 8(7):e1002848.
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  10. Woods DC, Tilly JL. The next (re)generation of ovarian biology and fertility in women: is current science tomorrow's practice? Fertil Steril. 2012 Jul; 98(1):3-10.
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  11. White YA, Woods DC, Takai Y, Ishihara O, Seki H, Tilly JL. Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women. Nat Med. 2012 Mar; 18(3):413-21.
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  12. Selesniemi K, Lee HJ, Muhlhauser A, Tilly JL. Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies. Proc Natl Acad Sci U S A. 2011 Jul 26; 108(30):12319-24.
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  13. Zelinski MB, Murphy MK, Lawson MS, Jurisicova A, Pau KY, Toscano NP, Jacob DS, Fanton JK, Casper RF, Dertinger SD, Tilly JL. In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates. Fertil Steril. 2011 Mar 15; 95(4):1440-5.e1-7.
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  14. Skaznik-Wikiel ME, Sharma RK, Selesniemi K, Lee HJ, Tilly JL, Falcone T. Granulocyte colony-stimulating factor in conjunction with vascular endothelial growth factor maintains primordial follicle numbers in transplanted mouse ovaries. Fertil Steril. 2011 Mar 15; 95(4):1405-9.
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  15. Niikura Y, Niikura T, Wang N, Satirapod C, Tilly JL. Systemic signals in aged males exert potent rejuvenating effects on the ovarian follicle reserve in mammalian females. Aging (Albany NY). 2010 Dec; 2(12):999-1003.
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  16. Wang N, Guo L, Rueda BR, Tilly JL. Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress. EMBO Rep. 2010 Aug; 11(8):633-9.
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  17. Rueda BR, Tilly JL, Schorge JO. Surgical debulking before or after chemotherapy: stemming the tide on ovarian cancer recurrence. Onkologie. 2010; 33(6):286-7.
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  18. Blagosklonny MV, Campisi J, Sinclair DA, Bartke A, Blasco MA, Bonner WM, Bohr VA, Brosh RM, Brunet A, Depinho RA, Donehower LA, Finch CE, Finkel T, Gorospe M, Gudkov AV, Hall MN, Hekimi S, Helfand SL, Karlseder J, Kenyon C, Kroemer G, Longo V, Nussenzweig A, Osiewacz HD, Peeper DS, Rando TA, Rudolph KL, Sassone-Corsi P, Serrano M, Sharpless NE, Skulachev VP, Tilly JL, Tower J, Verdin E, Vijg J. Impact papers on aging in 2009. Aging (Albany NY). 2010 Mar; 2(3):111-21.
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  19. Gong SP, Lee ST, Lee EJ, Kim DY, Lee G, Chi SG, Ryu BK, Lee CH, Yum KE, Lee HJ, Han JY, Tilly JL, Lim JM. Embryonic stem cell-like cells established by culture of adult ovarian cells in mice. Fertil Steril. 2010 May 15; 93(8):2594-601, 2601.e1-9.
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  20. Wang N, Tilly JL. Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonads. Cell Cycle. 2010 Jan 15; 9(2):339-49.
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  21. Niikura Y, Niikura T, Tilly JL. Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment. Aging (Albany NY). 2009 Dec; 1(12):971-8.
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  22. Tilly JL, Telfer EE. Purification of germline stem cells from adult mammalian ovaries: a step closer towards control of the female biological clock? Mol Hum Reprod. 2009 Jul; 15(7):393-8.
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  23. Pru JK, Kaneko-Tarui T, Jurisicova A, Kashiwagi A, Selesniemi K, Tilly JL. Induction of proapoptotic gene expression and recruitment of p53 herald ovarian follicle loss caused by polycyclic aromatic hydrocarbons. Reprod Sci. 2009 Apr; 16(4):347-56.
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  24. Selesniemi K, Lee HJ, Niikura T, Tilly JL. Young adult donor bone marrow infusions into female mice postpone age-related reproductive failure and improve offspring survival. Aging (Albany NY). 2009 Jan; 1(1):49-57.
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  25. Tilly JL, Niikura Y, Rueda BR. The current status of evidence for and against postnatal oogenesis in mammals: a case of ovarian optimism versus pessimism? Biol Reprod. 2009 Jan; 80(1):2-12.
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  26. Selesniemi K, Lee HJ, Tilly JL. Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age. Aging Cell. 2008 Oct; 7(5):622-9.
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  27. Tilly JL, Rueda BR. Minireview: stem cell contribution to ovarian development, function, and disease. Endocrinology. 2008 Sep; 149(9):4307-11.
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  28. Lee HJ, Selesniemi K, Niikura Y, Niikura T, Klein R, Dombkowski DM, Tilly JL. Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failure. J Clin Oncol. 2007 Aug 1; 25(22):3198-204.
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  29. Lee HJ, Sakamoto H, Luo H, Skaznik-Wikiel ME, Friel AM, Niikura T, Tilly JC, Niikura Y, Klein R, Styer AK, Zukerberg LR, Tilly JL, Rueda BR. Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female mice. Cell Cycle. 2007 Nov 1; 6(21):2678-84.
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  30. Tilly JL, Johnson J. Recent arguments against germ cell renewal in the adult human ovary: is an absence of marker gene expression really acceptable evidence of an absence of oogenesis? Cell Cycle. 2007 Apr 15; 6(8):879-83.
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  31. Takai Y, Matikainen T, Jurisicova A, Kim MR, Trbovich AM, Fujita E, Nakagawa T, Lemmers B, Flavell RA, Hakem R, Momoi T, Yuan J, Tilly JL, Perez GI. Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells. Apoptosis. 2007 Apr; 12(4):791-800.
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  32. Perez GI, Jurisicova A, Wise L, Lipina T, Kanisek M, Bechard A, Takai Y, Hunt P, Roder J, Grynpas M, Tilly JL. Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5229-34.
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  33. Skaznik-Wikiel M, Tilly JC, Lee HJ, Niikura Y, Kaneko-Tarui T, Johnson J, Tilly JL. Serious doubts over "Eggs forever?". Differentiation. 2007 Feb; 75(2):93-9.
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  34. Perez GI, Acton BM, Jurisicova A, Perkins GA, White A, Brown J, Trbovich AM, Kim MR, Fissore R, Xu J, Ahmady A, D'Estaing SG, Li H, Kagawa W, Kurumizaka H, Yokoyama S, Okada H, Mak TW, Ellisman MH, Casper RF, Tilly JL. Genetic variance modifies apoptosis susceptibility in mature oocytes via alterations in DNA repair capacity and mitochondrial ultrastructure. Cell Death Differ. 2007 Mar; 14(3):524-33.
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  35. Tilly JL. Personal reflections on Stan Korsmeyer and his continuing impact on our work to delineate the role of Bax in female reproduction. Cell Death Differ. 2006 Aug; 13(8):1296-8.
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  36. Jurisicova A, Lee HJ, D'Estaing SG, Tilly J, Perez GI. Molecular requirements for doxorubicin-mediated death in murine oocytes. Cell Death Differ. 2006 Sep; 13(9):1466-74.
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  37. Johnson J, Skaznik-Wikiel M, Lee HJ, Niikura Y, Tilly JC, Tilly JL. Setting the record straight on data supporting postnatal oogenesis in female mammals. Cell Cycle. 2005 Nov; 4(11):1471-7.
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  38. Johnson J, Bagley J, Skaznik-Wikiel M, Lee HJ, Adams GB, Niikura Y, Tschudy KS, Tilly JC, Cortes ML, Forkert R, Spitzer T, Iacomini J, Scadden DT, Tilly JL. Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell. 2005 Jul 29; 122(2):303-15.
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  39. Spaczynski RZ, Tilly JL, Mansour A, Duleba AJ. Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis. Mol Hum Reprod. 2005 May; 11(5):319-24.
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  40. Perez GI, Jurisicova A, Matikainen T, Moriyama T, Kim MR, Takai Y, Pru JK, Kolesnick RN, Tilly JL. A central role for ceramide in the age-related acceleration of apoptosis in the female germline. FASEB J. 2005 May; 19(7):860-2.
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  41. Oktay K, Tilly J. Livebirth after cryopreserved ovarian tissue autotransplantation. Lancet. 2004 Dec 11-17; 364(9451):2091-2; author reply 2092-3.
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  42. Dharmarajan AM, Goodman SB, Atiya N, Parkinson SP, Lareu RR, Tilly KI, Tilly JL. Role of apoptosis in functional luteolysis in the pregnant rabbit corpus luteum: evidence of a role for placental-derived factors in promoting luteal cell survival. Apoptosis. 2004 Nov; 9(6):807-14.
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  43. Preutthipan S, Chen SH, Tilly JL, Kugu K, Lareu RR, Dharmarajan AM. Inhibition of nitric oxide synthesis potentiates apoptosis in the rabbit corpus luteum. Reprod Biomed Online. 2004 Sep; 9(3):264-70.
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  44. Johnson J, Canning J, Kaneko T, Pru JK, Tilly JL. Germline stem cells and follicular renewal in the postnatal mammalian ovary. Nature. 2004 Mar 11; 428(6979):145-50.
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  45. Kim MR, Tilly JL. Current concepts in Bcl-2 family member regulation of female germ cell development and survival. Biochim Biophys Acta. 2004 Mar 1; 1644(2-3):205-10.
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  46. Tilly JL, Kolesnick RN. Realizing the promise of apoptosis-based therapies: separating the living from the clinically undead. Cell Death Differ. 2003 May; 10(5):493-5.
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  47. Tilly JL. Oocyte apoptosis: prevention strategies, and implications for female aging and the menopause. Ann Endocrinol (Paris). 2003 Apr; 64(2):82-4.
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  48. Jurisicova A, Antenos M, Varmuza S, Tilly JL, Casper RF. Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and Caspase-3 in blastomere fragmentation. Mol Hum Reprod. 2003 Mar; 9(3):133-41.
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  49. Carambula SF, Pru JK, Lynch MP, Matikainen T, Gonçalves PB, Flavell RA, Tilly JL, Rueda BR. Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves caspase-8 and is defective in caspase-3 deficient mice. Reprod Biol Endocrinol. 2003 Feb 11; 1:15.
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  50. Tilly JL. Ovarian follicle counts--not as simple as 1, 2, 3. Reprod Biol Endocrinol. 2003 Feb 6; 1:11.
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  51. Canning J, Takai Y, Tilly JL. Evidence for genetic modifiers of ovarian follicular endowment and development from studies of five inbred mouse strains. Endocrinology. 2003 Jan; 144(1):9-12.
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  52. Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology. 2003 Jan; 144(1):69-74.
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  53. Tilly JL, Kolesnick RN. Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility. Biochim Biophys Acta. 2002 Dec 30; 1585(2-3):135-8.
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  54. Paris F, Perez GI, Fuks Z, Haimovitz-Friedman A, Nguyen H, Bose M, Ilagan A, Hunt PA, Morgan WF, Tilly JL, Kolesnick R. Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring. Nat Med. 2002 Sep; 8(9):901-2.
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  55. Carambula SF, Matikainen T, Lynch MP, Flavell RA, Gonçalves PB, Tilly JL, Rueda BR. Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteum. Endocrinology. 2002 Apr; 143(4):1495-501.
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  56. Matikainen TM, Moriyama T, Morita Y, Perez GI, Korsmeyer SJ, Sherr DH, Tilly JL. Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells. Endocrinology. 2002 Feb; 143(2):615-20.
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  57. Pru JK, Tilly JL. Genomic plasticity in cell death susceptibility. Cell Death Differ. 2002 Feb; 9(2):96-8.
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  58. Tilly JL. Commuting the death sentence: how oocytes strive to survive. Nat Rev Mol Cell Biol. 2001 Nov; 2(11):838-48.
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  59. Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL, Clapham DE. A sperm ion channel required for sperm motility and male fertility. Nature. 2001 Oct 11; 413(6856):603-9.
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  60. Matikainen T, Perez GI, Jurisicova A, Pru JK, Schlezinger JJ, Ryu HY, Laine J, Sakai T, Korsmeyer SJ, Casper RF, Sherr DH, Tilly JL. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nat Genet. 2001 Aug; 28(4):355-60.
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  61. Morita Y, Maravei DV, Bergeron L, Wang S, Perez GI, Tsutsumi O, Taketani Y, Asano M, Horai R, Korsmeyer SJ, Iwakura Y, Yuan J, Tilly JL. Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function. Cell Death Differ. 2001 Jun; 8(6):614-20.
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  62. Matikainen T, Perez GI, Zheng TS, Kluzak TR, Rueda BR, Flavell RA, Tilly JL. Caspase-3 gene knockout defines cell lineage specificity for programmed cell death signaling in the ovary. Endocrinology. 2001 Jun; 142(6):2468-80.
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  63. Pru JK, Tilly JL. Programmed cell death in the ovary: insights and future prospects using genetic technologies. Mol Endocrinol. 2001 Jun; 15(6):845-53.
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  64. Tilly JL. Emerging technologies to control oocyte apoptosis are finally treading on fertile ground. ScientificWorldJournal. 2001 May 1; 1:181-3.
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  65. Lozano J, Morales A, Cremesti A, Fuks Z, Tilly JL, Schuchman E, Gulbins E, Kolesnick R. Niemann-Pick Disease versus acid sphingomyelinase deficiency. Cell Death Differ. 2001 Jan; 8(1):100-3.
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  66. Perez GI, Maravei DV, Trbovich AM, Cidlowski JA, Tilly JL, Hughes FM. Identification of potassium-dependent and -independent components of the apoptotic machinery in mouse ovarian germ cells and granulosa cells. Biol Reprod. 2000 Nov; 63(5):1358-69.
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  67. Morita Y, Perez GI, Paris F, Miranda SR, Ehleiter D, Haimovitz-Friedman A, Fuks Z, Xie Z, Reed JC, Schuchman EH, Kolesnick RN, Tilly JL. Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy. Nat Med. 2000 Oct; 6(10):1109-14.
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  68. Ratts VS, Tao XJ, Webster CB, Swanson PE, Smith SD, Brownbill P, Krajewski S, Reed JC, Tilly JL, Nelson DM. Expression of BCL-2, BAX and BAK in the trophoblast layer of the term human placenta: a unique model of apoptosis within a syncytium. Placenta. 2000 May; 21(4):361-6.
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  69. Morita Y, Tilly JL. Sphingolipid regulation of female gonadal cell apoptosis. Ann N Y Acad Sci. 2000 Apr; 905:209-20.
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  70. Perez GI, Trbovich AM, Gosden RG, Tilly JL. Mitochondria and the death of oocytes. Nature. 2000 Feb 3; 403(6769):500-1.
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  71. Robles R, Morita Y, Mann KK, Perez GI, Yang S, Matikainen T, Sherr DH, Tilly JL. The aryl hydrocarbon receptor, a basic helix-loop-helix transcription factor of the PAS gene family, is required for normal ovarian germ cell dynamics in the mouse. Endocrinology. 2000 Jan; 141(1):450-3.
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  72. Makrigiannakis A, Amin K, Coukos G, Tilly JL, Coutifaris C. Regulated expression and potential roles of p53 and Wilms' tumor suppressor gene (WT1) during follicular development in the human ovary. J Clin Endocrinol Metab. 2000 Jan; 85(1):449-59.
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  73. Tilly JL, Kolesnick RN. Sphingolipid signaling in gonadal development and function. Chem Phys Lipids. 1999 Nov; 102(1-2):149-55.
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  74. Xu L, Koumenis IL, Tilly JL, Giffard RG. Overexpression of bcl-xL protects astrocytes from glucose deprivation and is associated with higher glutathione, ferritin, and iron levels. Anesthesiology. 1999 Oct; 91(4):1036-46.
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  75. Morita Y, Tilly JL. Oocyte apoptosis: like sand through an hourglass. Dev Biol. 1999 Sep 1; 213(1):1-17.
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  76. Dharmarajan AM, Hisheh S, Singh B, Parkinson S, Tilly KI, Tilly JL. Antioxidants mimic the ability of chorionic gonadotropin to suppress apoptosis in the rabbit corpus luteum in vitro: a novel role for superoxide dismutase in regulating bax expression. Endocrinology. 1999 Jun; 140(6):2555-61.
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  77. Robles R, Tao XJ, Trbovich AM, Maravel DV, Nahum R, Perez GI, Tilly KI, Tilly JL. Localization, regulation and possible consequences of apoptotic protease-activating factor-1 (Apaf-1) expression in granulosa cells of the mouse ovary. Endocrinology. 1999 Jun; 140(6):2641-4.
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  78. Morita Y, Tilly JL. Segregation of retinoic acid effects on fetal ovarian germ cell mitosis versus apoptosis by requirement for new macromolecular synthesis. Endocrinology. 1999 Jun; 140(6):2696-703.
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  79. Morita Y, Perez GI, Maravei DV, Tilly KI, Tilly JL. Targeted expression of Bcl-2 in mouse oocytes inhibits ovarian follicle atresia and prevents spontaneous and chemotherapy-induced oocyte apoptosis in vitro. Mol Endocrinol. 1999 Jun; 13(6):841-50.
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  80. Perez GI, Tao XJ, Tilly JL. Fragmentation and death (a.k.a. apoptosis) of ovulated oocytes. Mol Hum Reprod. 1999 May; 5(5):414-20.
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  81. Rueda BR, Hendry IR, Tilly JL, Hamernik DL. Accumulation of caspase-3 messenger ribonucleic acid and induction of caspase activity in the ovine corpus luteum following prostaglandin F2alpha treatment in vivo. Biol Reprod. 1999 May; 60(5):1087-92.
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  82. Morita Y, Manganaro TF, Tao XJ, Martimbeau S, Donahoe PK, Tilly JL. Requirement for phosphatidylinositol-3'-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse. Endocrinology. 1999 Feb; 140(2):941-9.
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  83. Perez GI, Robles R, Knudson CM, Flaws JA, Korsmeyer SJ, Tilly JL. Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency. Nat Genet. 1999 Feb; 21(2):200-3.
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  84. Tilly JL. Molecular and genetic basis of normal and toxicant-induced apoptosis in female germ cells. Toxicol Lett. 1998 Dec 28; 102-103:497-501.
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  85. Goodman SB, Kugu K, Chen SH, Preutthipan S, Tilly KI, Tilly JL, Dharmarajan AM. Estradiol-mediated suppression of apoptosis in the rabbit corpus luteum is associated with a shift in expression of bcl-2 family members favoring cellular survival. Biol Reprod. 1998 Oct; 59(4):820-7.
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  86. Carsia RV, Nagele RG, Morita Y, Tilly KI, Tilly JL. Models to elucidate the regulation of adrenal cell death. Endocr Res. 1998 Aug-Nov; 24(3-4):899-908.
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  87. Tao XJ, Sayegh RA, Tilly JL, Isaacson KB. Elevated expression of the proapoptotic BCL-2 family member, BAK, in the human endometrium coincident with apoptosis during the secretory phase of the cycle. Fertil Steril. 1998 Aug; 70(2):338-43.
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  88. Bergeron L, Perez GI, Macdonald G, Shi L, Sun Y, Jurisicova A, Varmuza S, Latham KE, Flaws JA, Salter JC, Hara H, Moskowitz MA, Li E, Greenberg A, Tilly JL, Yuan J. Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev. 1998 May 1; 12(9):1304-14.
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  89. Kugu K, Ratts VS, Piquette GN, Tilly KI, Tao XJ, Martimbeau S, Aberdeen GW, Krajewski S, Reed JC, Pepe GJ, Albrecht ED, Tilly JL. Analysis of apoptosis and expression of bcl-2 gene family members in the human and baboon ovary. Cell Death Differ. 1998 Jan; 5(1):67-76.
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  90. Trbovich AM, Hughes FM, Perez GI, Kugu K, Tilly KI, Cidlowski JA, Tilly JL. High and low molecular weight DNA cleavage in ovarian granulosa cells: characterization and protease modulation in intact cells and in cell-free nuclear autodigestion assays. Cell Death Differ. 1998 Jan; 5(1):38-49.
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  91. Yamaguchi K, Matulka RA, Shneider AM, Toselli P, Trombino AF, Yang S, Hafer LJ, Mann KK, Tao XJ, Tilly JL, Near RI, Sherr DH. Induction of PreB cell apoptosis by 7,12-dimethylbenz[a]anthracene in long-term primary murine bone marrow cultures. Toxicol Appl Pharmacol. 1997 Dec; 147(2):190-203.
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  92. Perez GI, Tilly JL. Cumulus cells are required for the increased apoptotic potential in oocytes of aged mice. Hum Reprod. 1997 Dec; 12(12):2781-3.
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  93. Carsia RV, Tilly KI, Tilly JL. Hormonal modulation of apoptosis in the rat adrenal gland in vitro is dependent on structural integrity. Endocrine. 1997 Dec; 7(3):377-81.
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  94. Maravei DV, Trbovich AM, Perez GI, Tilly KI, Banach D, Talanian RV, Wong WW, Tilly JL. Cleavage of cytoskeletal proteins by caspases during ovarian cell death: evidence that cell-free systems do not always mimic apoptotic events in intact cells. Cell Death Differ. 1997 Dec; 4(8):707-12.
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  95. Dunkel L, Taskinen S, Hovatta O, Tilly JL, Wikström S. Germ cell apoptosis after treatment of cryptorchidism with human chorionic gonadotropin is associated with impaired reproductive function in the adult. J Clin Invest. 1997 Nov 1; 100(9):2341-6.
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  96. Johnson AL, Bridgham JT, Witty JP, Tilly JL. Expression of bcl-2 and nr-13 in hen ovarian follicles during development. Biol Reprod. 1997 Nov; 57(5):1096-103.
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  97. Perez GI, Knudson CM, Leykin L, Korsmeyer SJ, Tilly JL. Apoptosis-associated signaling pathways are required for chemotherapy-mediated female germ cell destruction. Nat Med. 1997 Nov; 3(11):1228-32.
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  98. Tao XJ, Tilly KI, Maravei DV, Shifren JL, Krajewski S, Reed JC, Tilly JL, Isaacson KB. Differential expression of members of the bcl-2 gene family in proliferative and secretory human endometrium: glandular epithelial cell apoptosis is associated with increased expression of bax. J Clin Endocrinol Metab. 1997 Aug; 82(8):2738-46.
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  99. Tilly JL, Tilly KI, Perez GI. The genes of cell death and cellular susceptibility to apoptosis in the ovary: a hypothesis. Cell Death Differ. 1997 Apr; 4(3):180-7.
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  100. Martimbeau S, Tilly JL. Physiological cell death in endocrine-dependent tissues: an ovarian perspective. Clin Endocrinol (Oxf). 1997 Mar; 46(3):241-54.
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  101. Tilly JL. Apoptosis and the ovary: a fashionable trend or food for thought? Fertil Steril. 1997 Feb; 67(2):226-8.
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  102. Rueda BR, Tilly KI, Botros IW, Jolly PD, Hansen TR, Hoyer PB, Tilly JL. Increased bax and interleukin-1beta-converting enzyme messenger ribonucleic acid levels coincide with apoptosis in the bovine corpus luteum during structural regression. Biol Reprod. 1997 Jan; 56(1):186-93.
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  103. Wang QF, Tilly KI, Tilly JL, Preffer F, Schneyer AL, Crowley WF, Sluss PM. Activin inhibits basal and androgen-stimulated proliferation and induces apoptosis in the human prostatic cancer cell line, LNCaP. Endocrinology. 1996 Dec; 137(12):5476-83.
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  104. Lei H, Furth EE, Kalluri R, Chiou T, Tilly KI, Tilly JL, Elkon KB, Jeffrey JJ, Strauss JF. A program of cell death and extracellular matrix degradation is activated in the amnion before the onset of labor. J Clin Invest. 1996 Nov 1; 98(9):1971-8.
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  105. Tilly JL. Apoptosis and ovarian function. Rev Reprod. 1996 Sep; 1(3):162-72.
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  106. Springer LN, Tilly JL, Sipes IG, Hoyer PB. Enhanced expression of bax in small preantral follicles during 4-vinylcyclohexene diepoxide-induced ovotoxicity in the rat. Toxicol Appl Pharmacol. 1996 Aug; 139(2):402-10.
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  107. Springer LN, McAsey ME, Flaws JA, Tilly JL, Sipes IG, Hoyer PB. Involvement of apoptosis in 4-vinylcyclohexene diepoxide-induced ovotoxicity in rats. Toxicol Appl Pharmacol. 1996 Aug; 139(2):394-401.
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  108. Johnson AL, Bridgham JT, Witty JP, Tilly JL. Susceptibility of avian ovarian granulosa cells to apoptosis is dependent upon stage of follicle development and is related to endogenous levels of bcl-xlong gene expression. Endocrinology. 1996 May; 137(5):2059-66.
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  109. Albrecht ED, Aberdeen GW, Babischkin JS, Tilly JL, Pepe GJ. Biphasic developmental expression of adrenocorticotropin receptor messenger ribonucleic acid levels in the baboon fetal adrenal gland. Endocrinology. 1996 Apr; 137(4):1292-8.
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  110. Pullan S, Wilson J, Metcalfe A, Edwards GM, Goberdhan N, Tilly J, Hickman JA, Dive C, Streuli CH. Requirement of basement membrane for the suppression of programmed cell death in mammary epithelium. J Cell Sci. 1996 Mar; 109 ( Pt 3):631-42.
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  111. Carsia RV, Macdonald GJ, Gibney JA, Tilly KI, Tilly JL. Apoptotic cell death in the rat adrenal gland: an in vivo and in vitro investigation. Cell Tissue Res. 1996 Feb; 283(2):247-54.
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  112. Tilly JL. The molecular basis of ovarian cell death during germ cell attrition, follicular atresia, and luteolysis. Front Biosci. 1996 Jan 1; 1:d1-11.
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  113. Regan RF, Panter SS, Witz A, Tilly JL, Giffard RG. Ultrastructure of excitotoxic neuronal death in murine cortical culture. Brain Res. 1995 Dec 24; 705(1-2):188-98.
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  114. Flaws JA, Kugu K, Trbovich AM, DeSanti A, Tilly KI, Hirshfield AN, Tilly JL. Interleukin-1 beta-converting enzyme-related proteases (IRPs) and mammalian cell death: dissociation of IRP-induced oligonucleosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle. Endocrinology. 1995 Nov; 136(11):5042-53.
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  115. Flaws JA, DeSanti A, Tilly KI, Javid RO, Kugu K, Johnson AL, Hirshfield AN, Tilly JL. Vasoactive intestinal peptide-mediated suppression of apoptosis in the ovary: potential mechanisms of action and evidence of a conserved antiatretogenic role through evolution. Endocrinology. 1995 Oct; 136(10):4351-9.
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  116. Banerjee PP, Banerjee S, Tilly KI, Tilly JL, Brown TR, Zirkin BR. Lobe-specific apoptotic cell death in rat prostate after androgen ablation by castration. Endocrinology. 1995 Oct; 136(10):4368-76.
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  117. Ratts VS, Flaws JA, Kolp R, Sorenson CM, Tilly JL. Ablation of bcl-2 gene expression decreases the numbers of oocytes and primordial follicles established in the post-natal female mouse gonad. Endocrinology. 1995 Aug; 136(8):3665-8.
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  118. Tilly KI, Banerjee S, Banerjee PP, Tilly JL. Expression of the p53 and Wilms' tumor suppressor genes in the rat ovary: gonadotropin repression in vivo and immunohistochemical localization of nuclear p53 protein to apoptotic granulosa cells of atretic follicles. Endocrinology. 1995 Apr; 136(4):1394-402.
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  119. Rueda BR, Tilly KI, Hansen TR, Hoyer PB, Tilly JL. Expression of superoxide dismutase, catalase and glutathione peroxidase in the bovine corpus luteum: evidence supporting a role for oxidative stress in luteolysis. Endocrine. 1995 Mar; 3(3):227-32.
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  120. Tilly JL, Tilly KI. Inhibitors of oxidative stress mimic the ability of follicle-stimulating hormone to suppress apoptosis in cultured rat ovarian follicles. Endocrinology. 1995 Jan; 136(1):242-52.
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  121. Tilly JL, Tilly KI, Kenton ML, Johnson AL. Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels. Endocrinology. 1995 Jan; 136(1):232-41.
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  122. Chun SY, Billig H, Tilly JL, Furuta I, Tsafriri A, Hsueh AJ. Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I. Endocrinology. 1994 Nov; 135(5):1845-53.
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  123. Piquette GN, Tilly JL, Prichard LE, Simón C, Polan ML. Detection of apoptosis in human and rat ovarian follicles. J Soc Gynecol Investig. 1994 Oct-Dec; 1(4):297-301.
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  124. Dunkel L, Tilly JL, Shikone T, Nishimori K, Hsueh AJ. Follicle-stimulating hormone receptor expression in the rat ovary: increases during prepubertal development and regulation by the opposing actions of transforming growth factors beta and alpha. Biol Reprod. 1994 Apr; 50(4):940-8.
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  125. Belizario JE, Tilly JL, Sherwood SW. Caffeine potentiates the lethality of tumour necrosis factor in cancer cells. Br J Cancer. 1993 Jun; 67(6):1229-35.
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  126. Tapanainen JS, Tilly JL, Vihko KK, Hsueh AJ. Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors. Mol Endocrinol. 1993 May; 7(5):643-50.
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  127. Carsia RV, McIlroy PJ, Kowalski KI, Tilly JL. Isolation of turkey adrenocortical cell angiotensin II (AII) receptor partial cDNA: evidence for a single-copy gene expressed predominantly in the adrenal gland. Biochem Biophys Res Commun. 1993 Mar 31; 191(3):1073-80.
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  128. Tilly JL, Hsueh AJ. Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation. J Cell Physiol. 1993 Mar; 154(3):519-26.
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  129. Tilly JL, Billig H, Kowalski KI, Hsueh AJ. Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism. Mol Endocrinol. 1992 Nov; 6(11):1942-50.
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  130. Tilly JL, Kowalski KI, Schomberg DW, Hsueh AJ. Apoptosis in atretic ovarian follicles is associated with selective decreases in messenger ribonucleic acid transcripts for gonadotropin receptors and cytochrome P450 aromatase. Endocrinology. 1992 Oct; 131(4):1670-6.
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  131. Tilly JL, Aihara T, Nishimori K, Jia XC, Billig H, Kowalski KI, Perlas EA, Hsueh AJ. Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts. Endocrinology. 1992 Aug; 131(2):799-806.
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  132. Tilly JL, LaPolt PS, Hsueh AJ. Hormonal regulation of follicle-stimulating hormone receptor messenger ribonucleic acid levels in cultured rat granulosa cells. Endocrinology. 1992 Mar; 130(3):1296-302.
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  133. LaPolt PS, Tilly JL, Aihara T, Nishimori K, Hsueh AJ. Gonadotropin-induced up- and down-regulation of ovarian follicle-stimulating hormone (FSH) receptor gene expression in immature rats: effects of pregnant mare's serum gonadotropin, human chorionic gonadotropin, and recombinant FSH. Endocrinology. 1992 Mar; 130(3):1289-95.
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  134. Tilly JL, Kowalski KI, Li Z, Levorse JM, Johnson AL. Plasminogen activator activity and thymidine incorporation in avian granulosa cells during follicular development and the periovulatory period. Biol Reprod. 1992 Feb; 46(2):195-200.
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  135. Tilly JL, Kowalski KI, Johnson AL. Cytochrome P450 side-chain cleavage (P450scc) in the hen ovary. II. P450scc messenger RNA, immunoreactive protein, and enzyme activity in developing granulosa cells. Biol Reprod. 1991 Dec; 45(6):967-74.
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  136. Kowalski KI, Tilly JL, Johnson AL. Cytochrome P450 side-chain cleavage (P450scc) in the hen ovary. I. Regulation of P450scc messenger RNA levels and steroidogenesis in theca cells of developing follicles. Biol Reprod. 1991 Dec; 45(6):955-66.
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  137. Tilly JL, Kowalski KI, Johnson AL, Hsueh AJ. Involvement of apoptosis in ovarian follicular atresia and postovulatory regression. Endocrinology. 1991 Nov; 129(5):2799-801.
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  138. Johnson AL, Tilly JL. Second messenger pathways mediating chicken luteinizing hormone secretion from dispersed pituitary cells. Biol Reprod. 1991 Jul; 45(1):64-72.
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  139. Levorse JM, Tilly JL, Johnson AL. Role of calcium in the regulation of theca cell androstenedione production in the domestic hen. J Reprod Fertil. 1991 May; 92(1):159-67.
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  140. Tilly JL, Kowalski KI, Johnson AL. Stage of ovarian follicular development associated with the initiation of steroidogenic competence in avian granulosa cells. Biol Reprod. 1991 Feb; 44(2):305-14.
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  141. Johnson AL, Tilly JL, Levorse JM. Possible role for arachidonic acid in the control of steroidogenesis in hen theca. Biol Reprod. 1991 Feb; 44(2):338-44.
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  142. Tilly JL, Johnson AL. Protein kinase C in preovulatory follicles from the hen ovary. Domest Anim Endocrinol. 1991 Jan; 8(1):1-13.
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  143. Johnson AL, Tilly JL. Evidence that arachidonic acid influences hen granulosa cell steroidogenesis and plasminogen activator activity by a protein kinase C-independent mechanism. Biol Reprod. 1990 Dec; 43(6):922-8.
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  144. Tilly JL, Johnson AL. Control of plasminogen activator activity in the thecal layer of the largest preovulatory follicle in the hen ovary. Endocrinology. 1990 Apr; 126(4):2079-87.
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  145. Johnson AL, Tilly JL. Arachidonic acid inhibits luteinizing hormone-stimulated progesterone production in hen granulosa cells. Biol Reprod. 1990 Mar; 42(3):458-64.
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  146. Tilly JL, Johnson AL. Effect of several growth factors on plasminogen activator activity in granulosa and theca cells of the domestic hen. Poult Sci. 1990 Feb; 69(2):292-9.
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  147. Tilly JL, Johnson AL. Modulation of hen granulosa cell steroidogenesis and plasminogen activator activity hy transforming growth factor alpha. Growth Factors. 1990; 3(3):247-55.
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  148. Tilly JL, Johnson AL. Regulation of androstenedione production by adenosine 3',5'-monophosphate and phorbol myristate acetate in ovarian thecal cells of the domestic hen. Endocrinology. 1989 Sep; 125(3):1691-9.
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  149. Tilly JL, Johnson AL. Effects of a phorbol ester, a calcium ionophore, and 3',5'-adenosine monophosphate production on hen granulosa cell plasminogen activator activity. Endocrinology. 1988 Sep; 123(3):1433-41.
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  150. Tilly JL, Johnson AL. Attenuation of hen granulosa cell steroidogenesis by a phorbol ester and 1-oleoyl-2-acetylglycerol. Biol Reprod. 1988 Aug; 39(1):1-8.
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  151. Johnson AL, Tilly JL. Effects of vasoactive intestinal peptide on steroid secretion and plasminogen activator activity in granulosa cells of the hen. Biol Reprod. 1988 Mar; 38(2):296-303.
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  152. Tilly JL, Johnson AL. Presence and hormonal control of plasminogen activator in granulosa cells of the domestic hen. Biol Reprod. 1987 Dec; 37(5):1156-64.
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