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William Francis Sewell, PH.D.

TitleProfessor of Otology and Laryngology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOtology and Laryngology
AddressMassachusetts Eye & Ear Infrm
Otology & Laryngology
243 Charles St
Boston MA 02114
Phone617/573-3156
Fax617/720-4408

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. McCall AA, Swan EE, Borenstein JT, Sewell WF, Kujawa SG, McKenna MJ. Drug delivery for treatment of inner ear disease: current state of knowledge. Ear Hear. 2010 Apr; 31(2):156-65.
    View in: PubMed
  2. Chen Z, Kujawa SG, Sewell WF. Functional roles of high-affinity glutamate transporters in cochlear afferent synaptic transmission in the mouse. J Neurophysiol. 2010 May; 103(5):2581-6.
    View in: PubMed
  3. Sewell WF, Borenstein JT, Chen Z, Fiering J, Handzel O, Holmboe M, Kim ES, Kujawa SG, McKenna MJ, Mescher MM, Murphy B, Swan EE, Peppi M, Tao S. Development of a microfluidics-based intracochlear drug delivery device. Audiol Neurootol. 2009; 14(6):411-22.
    View in: PubMed
  4. Chen Z, Peppi M, Kujawa SG, Sewell WF. Regulated expression of surface AMPA receptors reduces excitotoxicity in auditory neurons. J Neurophysiol. 2009 Aug; 102(2):1152-9.
    View in: PubMed
  5. Fiering J, Mescher MJ, Leary Swan EE, Holmboe ME, Murphy BA, Chen Z, Peppi M, Sewell WF, McKenna MJ, Kujawa SG, Borenstein JT. Local drug delivery with a self-contained, programmable, microfluidic system. Biomed Microdevices. 2009 Jun; 11(3):571-8.
    View in: PubMed
  6. Swan EE, Peppi M, Chen Z, Green KM, Evans JE, McKenna MJ, Mescher MJ, Kujawa SG, Sewell WF. Proteomics analysis of perilymph and cerebrospinal fluid in mouse. Laryngoscope. 2009 May; 119(5):953-8.
    View in: PubMed
  7. Handzel O, Wang H, Fiering J, Borenstein JT, Mescher MJ, Swan EE, Murphy BA, Chen Z, Peppi M, Sewell WF, Kujawa SG, McKenna MJ. Mastoid cavity dimensions and shape: method of measurement and virtual fitting of implantable devices. Audiol Neurootol. 2009; 14(5):308-14.
    View in: PubMed
  8. Sewell W, Sparrow DB, Smith AJ, Gonzalez DM, Rappaport EF, Dunwoodie SL, Kusumi K. Cyclical expression of the Notch/Wnt regulator Nrarp requires modulation by Dll3 in somitogenesis. Dev Biol. 2009 May 15; 329(2):400-9.
    View in: PubMed
  9. Swan EE, Mescher MJ, Sewell WF, Tao SL, Borenstein JT. Inner ear drug delivery for auditory applications. Adv Drug Deliv Rev. 2008 Dec 14; 60(15):1583-99.
    View in: PubMed
  10. Wang L, Sewell WF, Kim SD, Shin JT, MacRae CA, Zon LI, Seidman JG, Seidman CE. Eya4 regulation of Na+/K+-ATPase is required for sensory system development in zebrafish. Development. 2008 Oct; 135(20):3425-34.
    View in: PubMed
  11. Chen Z, Kujawa SG, Sewell WF. Auditory sensitivity regulation via rapid changes in expression of surface AMPA receptors. Nat Neurosci. 2007 Oct; 10(10):1238-40.
    View in: PubMed
  12. William DA, Saitta B, Gibson JD, Traas J, Markov V, Gonzalez DM, Sewell W, Anderson DM, Pratt SC, Rappaport EF, Kusumi K. Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model. Dev Biol. 2007 May 1; 305(1):172-86.
    View in: PubMed
  13. Chen Z, Kujawa SG, McKenna MJ, Fiering JO, Mescher MJ, Borenstein JT, Swan EE, Sewell WF. Inner ear drug delivery via a reciprocating perfusion system in the guinea pig. J Control Release. 2005 Dec 10; 110(1):1-19.
    View in: PubMed
  14. Sewell WF, Mroz EA, Evans JE. Extracts of retina and brain that excite afferent fibers innervating hair cells contain a compound related to hydroxyphenylglycine-N-carbamoyl. Synapse. 2005 Nov; 58(2):129-40.
    View in: PubMed
  15. Avanesov A, Dahm R, Sewell WF, Malicki JJ. Mutations that affect the survival of selected amacrine cell subpopulations define a new class of genetic defects in the vertebrate retina. Dev Biol. 2005 Sep 1; 285(1):138-55.
    View in: PubMed
  16. Chen Z, Mikulec AA, McKenna MJ, Sewell WF, Kujawa SG. A method for intracochlear drug delivery in the mouse. J Neurosci Methods. 2006 Jan 15; 150(1):67-73.
    View in: PubMed
  17. Dawkins R, Keller SL, Sewell WF. Pharmacology of acetylcholine-mediated cell signaling in the lateral line organ following efferent stimulation. J Neurophysiol. 2005 May; 93(5):2541-51.
    View in: PubMed
  18. Dawkins R, Sewell WF. Afferent synaptic transmission in a hair cell organ: pharmacological and physiological analysis of the role of the extended refractory period. J Neurophysiol. 2004 Aug; 92(2):1105-15.
    View in: PubMed
  19. Bang PI, Yelick PC, Malicki JJ, Sewell WF. High-throughput behavioral screening method for detecting auditory response defects in zebrafish. J Neurosci Methods. 2002 Aug 30; 118(2):177-87.
    View in: PubMed
  20. Bang PI, Sewell WF, Malicki JJ. Morphology and cell type heterogeneities of the inner ear epithelia in adult and juvenile zebrafish (Danio rerio). J Comp Neurol. 2001 Sep 17; 438(2):173-90.
    View in: PubMed
  21. Yoshida N, Liberman MC, Brown MC, Sewell WF. Fast, but not slow, effects of olivocochlear activation are resistant to apamin. J Neurophysiol. 2001 Jan; 85(1):84-8.
    View in: PubMed
  22. Bailey GP, Sewell WF. Pharmacological characterization of the CGRP receptor in the lateral line organ of Xenopus laevis. J Assoc Res Otolaryngol. 2000 Aug; 1(1):82-8.
    View in: PubMed
  23. Bailey GP, Sewell WF. Calcitonin gene-related peptide suppresses hair cell responses to mechanical stimulation in the Xenopus lateral line organ. J Neurosci. 2000 Jul 1; 20(13):5163-9.
    View in: PubMed
  24. Bailey GP, Sewell WF. Contribution of glutamate receptors to spontaneous and stimulus-evoked discharge in afferent fibers innervating hair cells of the Xenopus lateral line organ. Hear Res. 2000 Jun; 144(1-2):8-20.
    View in: PubMed
  25. Yoshida N, Liberman MC, Brown MC, Sewell WF. Gentamicin blocks both fast and slow effects of olivocochlear activation in anesthetized guinea pigs. J Neurophysiol. 1999 Dec; 82(6):3168-74.
    View in: PubMed
  26. Lee KH, McKenna MJ, Sewell WF, Ung F. Ribonucleases may limit recovery of ribonucleic acids from archival human temporal bones. Laryngoscope. 1997 Sep; 107(9):1228-34.
    View in: PubMed
  27. Sridhar TS, Brown MC, Sewell WF. Unique postsynaptic signaling at the hair cell efferent synapse permits calcium to evoke changes on two time scales. J Neurosci. 1997 Jan 1; 17(1):428-37.
    View in: PubMed
  28. Sridhar TS, Liberman MC, Brown MC, Sewell WF. A novel cholinergic "slow effect" of efferent stimulation on cochlear potentials in the guinea pig. J Neurosci. 1995 May; 15(5 Pt 1):3667-78.
    View in: PubMed
  29. Sewell WF, Mroz EA. Flavin adenine dinucleotide is a major endogenous fluorophore in the inner ear. Hear Res. 1993 Nov; 70(2):131-8.
    View in: PubMed
  30. Davis RL, Sewell WF. Neurite regeneration from single primary-auditory neurons in vitro. Hear Res. 1992 Feb; 58(1):107-21.
    View in: PubMed
  31. Sewell WF, Starr PA. Effects of calcitonin gene-related peptide and efferent nerve stimulation on afferent transmission in the lateral line organ. J Neurophysiol. 1991 May; 65(5):1158-69.
    View in: PubMed
  32. Starr PA, Sewell WF. Neurotransmitter release from hair cells and its blockade by glutamate-receptor antagonists. Hear Res. 1991 Mar; 52(1):23-41.
    View in: PubMed
  33. Sewell WF, Mroz EA. Purification of a low-molecular-weight excitatory substance from the inner ears of goldfish. Hear Res. 1990 Dec; 50(1-2):127-37.
    View in: PubMed
  34. Sewell WF. Synaptic potentials in afferent fibers innervating hair cells of the lateral line organ in Xenopus laevis. Hear Res. 1990 Feb; 44(1):71-81.
    View in: PubMed
  35. Mroz EA, Sewell WF. Pharmacological alterations of the activity of afferent fibers innervating hair cells. Hear Res. 1989 Mar; 38(1-2):141-62.
    View in: PubMed
  36. Adams JC, Mroz EA, Sewell WF. A possible neurotransmitter role for CGRP in a hair-cell sensory organ. Brain Res. 1987 Sep 1; 419(1-2):347-51.
    View in: PubMed
  37. Sewell WF, Mroz EA. Neuroactive substances in inner ear extracts. J Neurosci. 1987 Aug; 7(8):2465-75.
    View in: PubMed
  38. Sweeney TK, Mroz EA, Sewell WF. Isolation and culture of auditory cells from the goldfish (Carassius auratus). Hear Res. 1987; 28(2-3):153-60.
    View in: PubMed
  39. Kiang NY, Liberman MC, Sewell WF, Guinan JJ. Single unit clues to cochlear mechanisms. Hear Res. 1986; 22:171-82.
    View in: PubMed
  40. Sewell WF. Furosemide selectively reduces one component in rate-level functions from auditory-nerve fibers. Hear Res. 1984 Jul; 15(1):69-72.
    View in: PubMed
  41. Sewell WF. The effects of furosemide on the endocochlear potential and auditory-nerve fiber tuning curves in cats. Hear Res. 1984 Jun; 14(3):305-14.
    View in: PubMed
  42. Sewell WF. The relation between the endocochlear potential and spontaneous activity in auditory nerve fibres of the cat. J Physiol. 1984 Feb; 347:685-96.
    View in: PubMed
  43. Sewell WF, Norris CH, Tachibana M, Guth PS. Detection of an auditory nerve--activating substance. Science. 1978 Nov 24; 202(4370):910-2.
    View in: PubMed
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