Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Mark Adrian Exley, Ph.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Medicine/Gastroenterology/Thorn 1405
75 Francis St
Boston MA 02115
Phone617/732-8435
Fax617/730-5807

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Zeng SG, Ghnewa YG, O'Reilly VP, Lyons VG, Atzberger A, Hogan AE, Exley MA, Doherty DG. Human invariant NKT cell subsets differentially promote differentiation, antibody production, and T cell stimulation by B cells in vitro. J Immunol. 2013 Aug 15; 191(4):1666-76.
    View in: PubMed
  2. Mangan BA, Dunne MR, O'Reilly VP, Dunne PJ, Exley MA, O'Shea D, Scotet E, Hogan AE, Doherty DG. Cutting edge: CD1d restriction and th1/th2/th17 cytokine secretion by human vd3 T cells. J Immunol. 2013 Jul 1; 191(1):30-4.
    View in: PubMed
  3. Nowak-Machen M, Schmelzle M, Hanidziar D, Junger W, Exley M, Otterbein L, Wu Y, Csizmadia E, Doherty G, Sitkovsky M, Robson SC. Pulmonary natural killer T cells play an essential role in mediating hyperoxic acute lung injury. Am J Respir Cell Mol Biol. 2013 May; 48(5):601-9.
    View in: PubMed
  4. Yanagisawa K, Yue S, van der Vliet HJ, Wang R, Alatrakchi N, Golden-Mason L, Schuppan D, Koziel MJ, Rosen HR, Exley MA. Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C. J Viral Hepat. 2013 Aug; 20(8):556-65.
    View in: PubMed
  5. Li S, Vriend LE, Nasser IA, Popov Y, Afdhal NH, Koziel MJ, Schuppan D, Exley MA, Alatrakchi N. Hepatitis c virus-specific t-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis. Hepatology. 2012 Dec; 56(6):2094-105.
    View in: PubMed
  6. Rout N, Greene J, Yue S, O'Connor D, Johnson RP, Else JG, Exley MA, Kaur A. Loss of effector and anti-inflammatory natural killer T lymphocyte function in pathogenic simian immunodeficiency virus infection. PLoS Pathog. 2012 Sep; 8(9):e1002928.
    View in: PubMed
  7. Lynch L, Nowak M, Varghese B, Clark J, Hogan AE, Toxavidis V, Balk SP, O'Shea D, O'Farrelly C, Exley MA. Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production. Immunity. 2012 Sep 21; 37(3):574-87.
    View in: PubMed
  8. Kornek M, Lynch M, Mehta SH, Lai M, Exley M, Afdhal NH, Schuppan D. Circulating microparticles as disease-specific biomarkers of severity of inflammation in patients with hepatitis C or nonalcoholic steatohepatitis. Gastroenterology. 2012 Aug; 143(2):448-58.
    View in: PubMed
  9. Exley MA. Editorial: NKT get the 'flu: NKT cells as (mostly) good guys in influenza; monocytic cells as double agents. J Leukoc Biol. 2012 Mar; 91(3):349-52.
    View in: PubMed
  10. Chu X, Kilpatrick E, Xiao X, Liu W, Demirci G, Exley M, Li XC. Islet allograft tolerance in the absence of invariant natural killer T cells. Clin Immunol. 2011 Dec; 141(3):268-72.
    View in: PubMed
  11. Exley MA, Boyson JE. Protective role of regulatory decidual ?d T cells in pregnancy. Clin Immunol. 2011 Dec; 141(3):236-9.
    View in: PubMed
  12. Tun-Kyi A, Finn G, Greenwood A, Nowak M, Lee TH, Asara JM, Tsokos GC, Fitzgerald K, Israel E, Li X, Exley M, Nicholson LK, Lu KP. Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity. Nat Immunol. 2011 Aug; 12(8):733-41.
    View in: PubMed
  13. Exley MA, Lynch L, Varghese B, Nowak M, Alatrakchi N, Balk SP. Developing understanding of the roles of CD1d-restricted T cell subsets in cancer: reversing tumor-induced defects. Clin Immunol. 2011 Aug; 140(2):184-95.
    View in: PubMed
  14. Exley MA, Nakayama T. NKT-cell-based immunotherapies in clinical trials. Clin Immunol. 2011 Aug; 140(2):117-8.
    View in: PubMed
  15. Hogan AE, O'Reilly V, Dunne MR, Dere RT, Zeng SG, O'Brien C, Amu S, Fallon PG, Exley MA, O'Farrelly C, Zhu X, Doherty DG. Activation of human invariant natural killer T cells with a thioglycoside analogue of a-galactosylceramide. Clin Immunol. 2011 Aug; 140(2):196-207.
    View in: PubMed
  16. Schneiders FL, de Bruin R, Exley MA, van der Vliet HJ. Nuancing the proposed role of NKT cells in aging. Virulence. 2011 Mar-Apr; 2(2):170; author reply 171.
    View in: PubMed
  17. Song W, Tai YT, Tian Z, Hideshima T, Chauhan D, Nanjappa P, Exley MA, Anderson KC, Munshi NC. HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells. Leukemia. 2011 Jan; 25(1):161-8.
    View in: PubMed
  18. Budd R, Huber S, Exley MA. Comment on "Essential Role of IL-17A in the formation of a mycobacterial infection-induced granuloma in the lung". J Immunol. 2010 Aug 15; 185(4):1991; author reply 1991-2.
    View in: PubMed
  19. Exley MA, Wilson B, Balk SP. Isolation and functional use of human NKT cells. Curr Protoc Immunol. 2010 Aug; Chapter 14:Unit 14.11.
    View in: PubMed
  20. Rout N, Else JG, Yue S, Connole M, Exley MA, Kaur A. Heterogeneity in phenotype and function of CD8+ and CD4/CD8 double-negative Natural Killer T cell subsets in sooty mangabeys. J Med Primatol. 2010 Aug; 39(4):224-34.
    View in: PubMed
  21. Zeissig S, Dougan SK, Barral DC, Junker Y, Chen Z, Kaser A, Ho M, Mandel H, McIntyre A, Kennedy SM, Painter GF, Veerapen N, Besra GS, Cerundolo V, Yue S, Beladi S, Behar SM, Chen X, Gumperz JE, Breckpot K, Raper A, Baer A, Exley MA, Hegele RA, Cuchel M, Rader DJ, Davidson NO, Blumberg RS. Primary deficiency of microsomal triglyceride transfer protein in human abetalipoproteinemia is associated with loss of CD1 function. J Clin Invest. 2010 Aug; 120(8):2889-99.
    View in: PubMed
  22. Nowak M, Arredouani MS, Tun-Kyi A, Schmidt-Wolf I, Sanda MG, Balk SP, Exley MA. Defective NKT cell activation by CD1d+ TRAMP prostate tumor cells is corrected by interleukin-12 with a-galactosylceramide. PLoS One. 2010; 5(6):e11311.
    View in: PubMed
  23. Rout N, Else JG, Yue S, Connole M, Exley MA, Kaur A. Paucity of CD4+ natural killer T (NKT) lymphocytes in sooty mangabeys is associated with lack of NKT cell depletion after SIV infection. PLoS One. 2010; 5(3):e9787.
    View in: PubMed
  24. Nowak M, Lynch L, Yue S, Ohta A, Sitkovsky M, Balk SP, Exley MA. The A2aR adenosine receptor controls cytokine production in iNKT cells. Eur J Immunol. 2010 Mar; 40(3):682-7.
    View in: PubMed
  25. Beziat V, Nguyen S, Exley M, Achour A, Simon T, Chevallier P, Sirvent A, Vigouroux S, Debré P, Rio B, Vieillard V. Shaping of iNKT cell repertoire after unrelated cord blood transplantation. Clin Immunol. 2010 Jun; 135(3):364-73.
    View in: PubMed
  26. Yue SC, Nowak M, Shaulov-Kask A, Wang R, Yue D, Balk SP, Exley MA. Direct CD1d-mediated stimulation of APC IL-12 production and protective immune response to virus infection in vivo. J Immunol. 2010 Jan 1; 184(1):268-76.
    View in: PubMed
  27. Teng MW, Sharkey J, McLaughlin NM, Exley MA, Smyth MJ. CD1d-based combination therapy eradicates established tumors in mice. J Immunol. 2009 Aug 1; 183(3):1911-20.
    View in: PubMed
  28. Teng MW, Yue S, Sharkey J, Exley MA, Smyth MJ. CD1d activation and blockade: a new antitumor strategy. J Immunol. 2009 Mar 15; 182(6):3366-71.
    View in: PubMed
  29. Song W, van der Vliet HJ, Tai YT, Prabhala R, Wang R, Podar K, Catley L, Shammas MA, Anderson KC, Balk SP, Exley MA, Munshi NC. Generation of antitumor invariant natural killer T cell lines in multiple myeloma and promotion of their functions via lenalidomide: a strategy for immunotherapy. Clin Cancer Res. 2008 Nov 1; 14(21):6955-62.
    View in: PubMed
  30. Beldi G, Wu Y, Banz Y, Nowak M, Miller L, Enjyoji K, Haschemi A, Yegutkin GG, Candinas D, Exley M, Robson SC. Natural killer T cell dysfunction in CD39-null mice protects against concanavalin A-induced hepatitis. Hepatology. 2008 Sep; 48(3):841-52.
    View in: PubMed
  31. Exley MA, Hou R, Shaulov A, Tonti E, Dellabona P, Casorati G, Akbari O, Akman HO, Greenfield EA, Gumperz JE, Boyson JE, Balk SP, Wilson SB. Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop. Eur J Immunol. 2008 Jun; 38(6):1756-66.
    View in: PubMed
  32. van der Vliet HJ, Wang R, Yue SC, Koon HB, Balk SP, Exley MA. Circulating myeloid dendritic cells of advanced cancer patients result in reduced activation and a biased cytokine profile in invariant NKT cells. J Immunol. 2008 Jun 1; 180(11):7287-93.
    View in: PubMed
  33. Shaulov A, Yue S, Wang R, Joyce RM, Balk SP, Kim HT, Avigan DE, Uhl L, Sackstein R, Exley MA. Peripheral blood progenitor cell product contains Th1-biased noninvariant CD1d-reactive natural killer T cells: implications for posttransplant survival. Exp Hematol. 2008 Apr; 36(4):464-72.
    View in: PubMed
  34. Gansuvd B, Goodwin J, Asiedu CK, Jiang XL, Jargal U, Andrades P, Exley MA, Thomas JM. Invariant natural killer T cells from rhesus macaque spleen and peripheral blood are phenotypically and functionally distinct populations. J Med Primatol. 2008 Feb; 37(1):1-11.
    View in: PubMed
  35. van der Vliet HJ, Koon HB, Atkins MB, Balk SP, Exley MA. Exploiting regulatory T-cell populations for the immunotherapy of cancer. J Immunother. 2007 Sep; 30(6):591-5.
    View in: PubMed
  36. van der Vliet HJ, van der Vliet HJ, Koon HB, Yue SC, Uzunparmak B, Seery V, Gavin MA, Rudensky AY, Atkins MB, Balk SP, Exley MA. Effects of the administration of high-dose interleukin-2 on immunoregulatory cell subsets in patients with advanced melanoma and renal cell cancer. Clin Cancer Res. 2007 Apr 1; 13(7):2100-8.
    View in: PubMed
  37. Alatrakchi N, Graham CS, van der Vliet HJ, Sherman KE, Exley MA, Koziel MJ. Hepatitis C virus (HCV)-specific CD8+ cells produce transforming growth factor beta that can suppress HCV-specific T-cell responses. J Virol. 2007 Jun; 81(11):5882-92.
    View in: PubMed
  38. Speak AO, Salio M, Neville DC, Fontaine J, Priestman DA, Platt N, Heare T, Butters TD, Dwek RA, Trottein F, Exley MA, Cerundolo V, Platt FM. Implications for invariant natural killer T cell ligands due to the restricted presence of isoglobotrihexosylceramide in mammals. Proc Natl Acad Sci U S A. 2007 Apr 3; 104(14):5971-6.
    View in: PubMed
  39. Yanagisawa K, Exley MA, Jiang X, Ohkochi N, Taniguchi M, Seino K. Hyporesponsiveness to natural killer T-cell ligand alpha-galactosylceramide in cancer-bearing state mediated by CD11b+ Gr-1+ cells producing nitric oxide. Cancer Res. 2006 Dec 1; 66(23):11441-6.
    View in: PubMed
  40. van der Vliet HJ, Balk SP, Exley MA. Natural killer T cell-based cancer immunotherapy. Clin Cancer Res. 2006 Oct 15; 12(20 Pt 1):5921-3.
    View in: PubMed
  41. Kenna T, O'Brien M, Hogan AE, Exley MA, Porcelli SA, Hegarty JE, O'Farrelly C, Doherty DG. CD1 expression and CD1-restricted T cell activity in normal and tumour-bearing human liver. Cancer Immunol Immunother. 2007 Apr; 56(4):563-72.
    View in: PubMed
  42. Ilyinskii PO, Wang R, Balk SP, Exley MA. CD1d mediates T-cell-dependent resistance to secondary infection with encephalomyocarditis virus (EMCV) in vitro and immune response to EMCV infection in vivo. J Virol. 2006 Jul; 80(14):7146-58.
    View in: PubMed
  43. Lang GA, Exley MA, Lang ML. The CD1d-binding glycolipid alpha-galactosylceramide enhances humoral immunity to T-dependent and T-independent antigen in a CD1d-dependent manner. Immunology. 2006 Sep; 119(1):116-25.
    View in: PubMed
  44. Boyson JE, Nagarkatti N, Nizam L, Exley MA, Strominger JL. Gestation stage-dependent mechanisms of invariant natural killer T cell-mediated pregnancy loss. Proc Natl Acad Sci U S A. 2006 Mar 21; 103(12):4580-5.
    View in: PubMed
  45. Sonoda KH, Sakamoto T, Qiao H, Hisatomi T, Oshima T, Tsutsumi-Miyahara C, Exley M, Balk SP, Taniguchi M, Ishibashi T. The analysis of systemic tolerance elicited by antigen inoculation into the vitreous cavity: vitreous cavity-associated immune deviation. Immunology. 2005 Nov; 116(3):390-9.
    View in: PubMed
  46. Yue SC, Shaulov A, Wang R, Balk SP, Exley MA. CD1d ligation on human monocytes directly signals rapid NF-kappaB activation and production of bioactive IL-12. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11811-6.
    View in: PubMed
  47. Dougan SK, Salas A, Rava P, Agyemang A, Kaser A, Morrison J, Khurana A, Kronenberg M, Johnson C, Exley M, Hussain MM, Blumberg RS. Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells. J Exp Med. 2005 Aug 15; 202(4):529-39.
    View in: PubMed
  48. Cho S, Knox KS, Kohli LM, He JJ, Exley MA, Wilson SB, Brutkiewicz RR. Impaired cell surface expression of human CD1d by the formation of an HIV-1 Nef/CD1d complex. Virology. 2005 Jul 5; 337(2):242-52.
    View in: PubMed
  49. Nieuwenhuis EE, Gillessen S, Scheper RJ, Exley MA, Taniguchi M, Balk SP, Strominger JL, Dranoff G, Blumberg RS, Wilson SB. CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity. Exp Dermatol. 2005 Apr; 14(4):250-8.
    View in: PubMed
  50. Exley MA, Koziel MJ. To be or not to be NKT: natural killer T cells in the liver. Hepatology. 2004 Nov; 40(5):1033-40.
    View in: PubMed
  51. Christopher K, Liang Y, Mueller TF, DeFina R, He H, Haley KJ, Exley MA, Finn PW, Perkins DL. Analysis of the major histocompatibility complex in graft rejection revisited by gene expression profiles. Transplantation. 2004 Sep 27; 78(6):788-98.
    View in: PubMed
  52. Durante-Mangoni E, Wang R, Shaulov A, He Q, Nasser I, Afdhal N, Koziel MJ, Exley MA. Hepatic CD1d expression in hepatitis C virus infection and recognition by resident proinflammatory CD1d-reactive T cells. J Immunol. 2004 Aug 1; 173(3):2159-66.
    View in: PubMed
  53. Fuss IJ, Heller F, Boirivant M, Leon F, Yoshida M, Fichtner-Feigl S, Yang Z, Exley M, Kitani A, Blumberg RS, Mannon P, Strober W. Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis. J Clin Invest. 2004 May; 113(10):1490-7.
    View in: PubMed
  54. Brozovic S, Nagaishi T, Yoshida M, Betz S, Salas A, Chen D, Kaser A, Glickman J, Kuo T, Little A, Morrison J, Corazza N, Kim JY, Colgan SP, Young SG, Exley M, Blumberg RS. CD1d function is regulated by microsomal triglyceride transfer protein. Nat Med. 2004 May; 10(5):535-9.
    View in: PubMed
  55. Exley MA, Bigley NJ, Cheng O, Shaulov A, Tahir SM, Carter QL, Garcia J, Wang C, Patten K, Stills HF, Alt FW, Snapper SB, Balk SP. Innate immune response to encephalomyocarditis virus infection mediated by CD1d. Immunology. 2003 Dec; 110(4):519-26.
    View in: PubMed
  56. Levy O, Orange JS, Hibberd P, Steinberg S, LaRussa P, Weinberg A, Wilson SB, Shaulov A, Fleisher G, Geha RS, Bonilla FA, Exley M. Disseminated varicella infection due to the vaccine strain of varicella-zoster virus, in a patient with a novel deficiency in natural killer T cells. J Infect Dis. 2003 Oct 1; 188(7):948-53.
    View in: PubMed
  57. Gansuvd B, Hubbard WJ, Hutchings A, Thomas FT, Goodwin J, Wilson SB, Exley MA, Thomas JM. Phenotypic and functional characterization of long-term cultured rhesus macaque spleen-derived NKT cells. J Immunol. 2003 Sep 15; 171(6):2904-11.
    View in: PubMed
  58. Gillessen S, Naumov YN, Nieuwenhuis EE, Exley MA, Lee FS, Mach N, Luster AD, Blumberg RS, Taniguchi M, Balk SP, Strominger JL, Dranoff G, Wilson SB. CD1d-restricted T cells regulate dendritic cell function and antitumor immunity in a granulocyte-macrophage colony-stimulating factor-dependent fashion. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8874-9.
    View in: PubMed
  59. Huber S, Sartini D, Exley M. Role of CD1d in coxsackievirus B3-induced myocarditis. J Immunol. 2003 Mar 15; 170(6):3147-53.
    View in: PubMed
  60. Exley MA, Balk SP, Wilson SB. Isolation and functional use of human NK T cells. Curr Protoc Immunol. 2003 Feb; Chapter 14:Unit 14.11.
    View in: PubMed
  61. Huber SA, Sartini D, Exley M. Vgamma4(+) T cells promote autoimmune CD8(+) cytolytic T-lymphocyte activation in coxsackievirus B3-induced myocarditis in mice: role for CD4(+) Th1 cells. J Virol. 2002 Nov; 76(21):10785-90.
    View in: PubMed
  62. Boyson JE, Rybalov B, Koopman LA, Exley M, Balk SP, Racke FK, Schatz F, Masch R, Wilson SB, Strominger JL. CD1d and invariant NKT cells at the human maternal-fetal interface. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13741-6.
    View in: PubMed
  63. Nieuwenhuis EE, Matsumoto T, Exley M, Schleipman RA, Glickman J, Bailey DT, Corazza N, Colgan SP, Onderdonk AB, Blumberg RS. CD1d-dependent macrophage-mediated clearance of Pseudomonas aeruginosa from lung. Nat Med. 2002 Jun; 8(6):588-93.
    View in: PubMed
  64. Exley MA, He Q, Cheng O, Wang RJ, Cheney CP, Balk SP, Koziel MJ. Cutting edge: Compartmentalization of Th1-like noninvariant CD1d-reactive T cells in hepatitis C virus-infected liver. J Immunol. 2002 Feb 15; 168(4):1519-23.
    View in: PubMed
  65. Kukreja A, Cost G, Marker J, Zhang C, Sun Z, Lin-Su K, Ten S, Sanz M, Exley M, Wilson B, Porcelli S, Maclaren N. Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest. 2002 Jan; 109(1):131-40.
    View in: PubMed
  66. Exley MA, Tahir SM, Cheng O, Shaulov A, Joyce R, Avigan D, Sackstein R, Balk SP. A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J Immunol. 2001 Nov 15; 167(10):5531-4.
    View in: PubMed
  67. Naumov YN, Bahjat KS, Gausling R, Abraham R, Exley MA, Koezuka Y, Balk SB, Strominger JL, Clare-Salzer M, Wilson SB. Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13838-43.
    View in: PubMed
  68. Tahir SM, Cheng O, Shaulov A, Koezuka Y, Bubley GJ, Wilson SB, Balk SP, Exley MA. Loss of IFN-gamma production by invariant NK T cells in advanced cancer. J Immunol. 2001 Oct 1; 167(7):4046-50.
    View in: PubMed
  69. Stremmel C, Exley M, Balk S, Hohenberger W, Kuchroo VK. Characterization of the phenotype and function of CD8(+), alpha / beta(+) NKT cells from tumor-bearing mice that show a natural killer cell activity and lyse multiple tumor targets. Eur J Immunol. 2001 Sep; 31(9):2818-28.
    View in: PubMed
  70. Exley MA, Bigley NJ, Cheng O, Tahir SM, Smiley ST, Carter QL, Stills HF, Grusby MJ, Koezuka Y, Taniguchi M, Balk SP. CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus. J Leukoc Biol. 2001 May; 69(5):713-8.
    View in: PubMed
  71. Wang B, Chun T, Rulifson IC, Exley M, Balk SP, Wang CR. Human CD1d functions as a transplantation antigen and a restriction element in mice. J Immunol. 2001 Mar 15; 166(6):3829-36.
    View in: PubMed
  72. Dao T, Exley M, Mehal WZ, Tahir SM, Snapper S, Taniguchi M, Balk SP, Crispe IN. Involvement of CD1 in peripheral deletion of T lymphocytes is independent of NK T cells. J Immunol. 2001 Mar 1; 166(5):3090-7.
    View in: PubMed
  73. Sonoda KH, Faunce DE, Taniguchi M, Exley M, Balk S, Stein-Streilein J. NK T cell-derived IL-10 is essential for the differentiation of antigen-specific T regulatory cells in systemic tolerance. J Immunol. 2001 Jan 1; 166(1):42-50.
    View in: PubMed
  74. Saubermann LJ, Beck P, De Jong YP, Pitman RS, Ryan MS, Kim HS, Exley M, Snapper S, Balk SP, Hagen SJ, Kanauchi O, Motoki K, Sakai T, Terhorst C, Koezuka Y, Podolsky DK, Blumberg RS. Activation of natural killer T cells by alpha-galactosylceramide in the presence of CD1d provides protection against colitis in mice. Gastroenterology. 2000 Jul; 119(1):119-28.
    View in: PubMed
  75. Exley M, Garcia J, Wilson SB, Spada F, Gerdes D, Tahir SM, Patton KT, Blumberg RS, Porcelli S, Chott A, Balk SP. CD1d structure and regulation on human thymocytes, peripheral blood T cells, B cells and monocytes. Immunology. 2000 May; 100(1):37-47.
    View in: PubMed
  76. Sonoda KH, Exley M, Snapper S, Balk SP, Stein-Streilein J. CD1-reactive natural killer T cells are required for development of systemic tolerance through an immune-privileged site. J Exp Med. 1999 Nov 1; 190(9):1215-26.
    View in: PubMed
  77. Kim HS, Garcia J, Exley M, Johnson KW, Balk SP, Blumberg RS. Biochemical characterization of CD1d expression in the absence of beta2-microglobulin. J Biol Chem. 1999 Apr 2; 274(14):9289-95.
    View in: PubMed
  78. Exley M, Porcelli S, Furman M, Garcia J, Balk S. CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant V alpha 24 J alpha Q T cell receptor alpha chains. J Exp Med. 1998 Sep 7; 188(5):867-76.
    View in: PubMed
  79. Wilson SB, Kent SC, Patton KT, Orban T, Jackson RA, Exley M, Porcelli S, Schatz DA, Atkinson MA, Balk SP, Strominger JL, Hafler DA. Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature. 1998 Jan 8; 391(6663):177-81.
    View in: PubMed
  80. de Aós I, Metzger MH, Exley M, Dahl CE, Misra S, Zheng D, Varticovski L, Terhorst C, Sancho J. Tyrosine phosphorylation of the CD3-epsilon subunit of the T cell antigen receptor mediates enhanced association with phosphatidylinositol 3-kinase in Jurkat T cells. J Biol Chem. 1997 Oct 3; 272(40):25310-8.
    View in: PubMed
  81. Exley M, Garcia J, Balk SP, Porcelli S. Requirements for CD1d recognition by human invariant Valpha24+ CD4-CD8- T cells. J Exp Med. 1997 Jul 7; 186(1):109-20.
    View in: PubMed
  82. Exley M, Varticovski L. Evidence for phosphatidylinositol 3-kinase-dependent T cell antigen receptor (TCR) signal transduction. Mol Immunol. 1997 Feb; 34(3):221-6.
    View in: PubMed
  83. Fox BS, Kantak KM, Edwards MA, Black KM, Bollinger BK, Botka AJ, French TL, Thompson TL, Schad VC, Greenstein JL, Gefter ML, Exley MA, Swain PA, Briner TJ. Efficacy of a therapeutic cocaine vaccine in rodent models. Nat Med. 1996 Oct; 2(10):1129-32.
    View in: PubMed
  84. Exley M, Wileman T, Mueller B, Terhorst C. Evidence for multivalent structure of T-cell antigen receptor complex. Mol Immunol. 1995 Aug; 32(11):829-39.
    View in: PubMed
  85. Exley M, Varticovski L, Peter M, Sancho J, Terhorst C. Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation. J Biol Chem. 1994 May 27; 269(21):15140-6.
    View in: PubMed
  86. Young J, Kane LP, Exley M, Wileman T. Regulation of selective protein degradation in the endoplasmic reticulum by redox potential. J Biol Chem. 1993 Sep 15; 268(26):19810-8.
    View in: PubMed
  87. Terhorst C, Exley M, Franco R, Hall C, Kang J, Mueller B, Sancho J, She J, Wileman T. Coupling of T-cell activation with T-cell receptor assembly. Year Immunol. 1993; 7:1-24.
    View in: PubMed
  88. Exley M, Terhorst C, Wileman T. Structure, assembly and intracellular transport of the T cell receptor for antigen. Semin Immunol. 1991 Sep; 3(5):283-97.
    View in: PubMed
  89. Brahm J, McClure MO, Sommerfelt MA, Exley MA, Weiss RA, Fagan EA, Williams R. Lack of reverse transcriptase activity in serum in sporadic post-transfusional and presumed epidemic or water-borne forms of severe non-A, non-B hepatitis. J Med Virol. 1988 Jun; 25(2):157-64.
    View in: PubMed
  90. Clapham PR, Weiss RA, Dalgleish AG, Exley M, Whitby D, Hogg N. Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: receptor modulation and differentiation induced by phorbol ester. Virology. 1987 May; 158(1):44-51.
    View in: PubMed
  91. Clapham P, Nagy K, Cheingsong-Popov R, Exley M, Weiss RA. Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line. Science. 1983 Dec 9; 222(4628):1125-7.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Exley's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_