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Terry Barton Strom, M.D.

TitleProfessor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Medicine/The Transplant Institute/E-CLS/608
330 Brookline Ave
Boston MA 02215
Phone617/735-2880
Fax617/735-2902
Other Positions
TitleProfessor of Surgery
InstitutionBeth Israel Deaconess Medical Center
DepartmentSurgery


 Biography 
 awards and honors
1959 - 1961Academic Honors Day
1959 - 1966Scholar
1960 - 1962Student Senate
1976 - 1981Research Career Development Awardee
1979 - 1979Member
1981 - 1981President
1987 - 1991Councillor
1987 - 1987Member
1989 - 1996Councillor
1989 - 1989M.A. (Honorary)
1989 - 1989Member
1989 - 1990President
1990 - 1996Councillor
1990 - 1990D. Sc. (Honorary)
1990 - 1990Rupert Billingham Visiting Professor of Medicine
1991 - 1995Councillor
1991 - 1991Lilly Lecturer
1992 - Citation
1992 - 1992Visiting Professor
1995 - 1995Bernard Pimstone Memorial Lecturer
1995 - 1995Fellow
1995 - 1995John Kapp Clark Visiting Lecturer, Dept. of Medicine
1995 - 1995Sandoz Visiting Professor, Renal Unit
1996 - 2000Councillor
1997 - 1997First Annual Sandoz Transplant Established Investigator Award
1998 - 1998Visitng Professor
2001 - 2001Roche American Society of Transplantation Distinguished Achievement Award
2002 - Highly Cited Researcher
2004 - Councilor
2006 - 2006Homer W. Smith Award for "Exceptional Contributions to the Field of Nephrology"
2007 - 2007Guest Professor, Rupert Billingham Lectureship in Transplant Immunology
2008 - 2008Recipient of the Visiting Research Professor in Transplantation, Multi Organ Transplant Program
2009 - 2009Guest Professor, Idelson Lecturer
2010 - 2011Biotherapeutics Program Resident Professional Scholar
2011 - 2011Alfred Newton Richards Life-time Achievement Award

 Overview 
 overview
Our goal is to safely render transplant recipients tolerant to their transplants and restore self tolerance, thereby enabling transplant survival in the absence of maintenance in immunosuppressive medications and curing patients with autoimmune disorders such as Type 1 diabetes mellitus. Through use of basic and translational science, we are pursing this goal. At a basic level, we are analyzing the molecular pathways that foster commitment to T cell tissue destructive– and tissue protective-subsets as well as those that decommission such commitments. We use this knowledge to design molecules and regimens that foster immune tolerance. Therapies are tested in both mouse and non-human primate models. To date, our work has led to the FDA approved use of anti-CD25 monoclonal antibodies in transplantation and autoimmunity and an IL2-diphtheria toxin related fusion protein for treatment of T-cell malignancies. These new regimens, one includes use of Ig fusion proteins that use designed and tested in mouse and monkey models, are funded for clinical trials in new onset Type 1 diabetes and islet transplantation. To aid deployment of potentially tolerizing therapies we have also identified molecular signatures that are present in peripheral blood mononuclear cells well in advance of clinically evident kidney transplant rejection. The validity of this signature is now being tested in doubled blind trials.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Chandraker A, Strom TB. Transplantation: A new molecular approach to the diagnosis of acute rejection. Nat Rev Nephrol. 2013 Nov; 9(11):631-2.
    View in: PubMed
  2. Carlson AL, Fujisaki J, Wu J, Runnels JM, Turcotte R, Celso CL, Scadden DT, Strom TB, Lin CP. Tracking single cells in live animals using a photoconvertible near-infrared cell membrane label. PLoS One. 2013; 8(8):e69257.
    View in: PubMed
  3. Keslar KS, Lin M, Zmijewska AA, Sigdel TK, Tran TQ, Ma L, Bhasin M, Rao P, Ding R, Iklé DN, Mannon RB, Sarwal MM, Strom TB, Reed EF, Heeger PS, Suthanthiran M, Fairchild RL. Multicenter evaluation of a standardized protocol for noninvasive gene expression profiling. Am J Transplant. 2013 Jul; 13(7):1891-7.
    View in: PubMed
  4. Strom TB. Transplant rejection and paradigms lost. J Clin Invest. 2013 Jun 3; 123(6):2360-2.
    View in: PubMed
  5. Yang X, Kallarakal A, Saptharishi N, Jiang H, Yang Z, Xie Y, Mitra G, Zheng XX, Strom TB, Soman G. Molecular Characterization and Functional Activity of an IL-15 Antagonist MutIL-15/Fc Human Fusion Protein. Mol Pharm. 2013 Feb 4; 10(2):717-27.
    View in: PubMed
  6. Balasubramanian S, Kota SK, Kuchroo VK, Humphreys BD, Strom TB. TIM Family Proteins Promote the Lysosomal Degradation of the Nuclear Receptor NUR77. Sci Signal. 2012; 5(254):ra90.
    View in: PubMed
  7. Moraes-Vieira PM, Bassi EJ, Larocca RA, Castoldi A, Burghos M, Lepique AP, Quintana FJ, Araujo RC, Basso AS, Strom TB, Câmara NO. Leptin modulates allograft survival by favoring a th2 and a regulatory immune profile. Am J Transplant. 2013 Jan; 13(1):36-44.
    View in: PubMed
  8. Koulmanda M, Bhasin M, Fan Z, Hanidziar D, Goel N, Putheti P, Movahedi B, Libermann TA, Strom TB. Alpha 1-antitrypsin reduces inflammation and enhances mouse pancreatic islet transplant survival. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15443-8.
    View in: PubMed
  9. Gupta S, Thornley TB, Gao W, Larocca R, Turka LA, Kuchroo VK, Strom TB. Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs. J Clin Invest. 2012 Jul 2; 122(7):2395-404.
    View in: PubMed
  10. Veenstra RG, Taylor PA, Zhou Q, Panoskaltsis-Mortari A, Hirashima M, Flynn R, Liu D, Anderson AC, Strom TB, Kuchroo VK, Blazar BR. Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells. Blood. 2012 Jul 19; 120(3):682-90.
    View in: PubMed
  11. Koulmanda M, Bhasin M, Awdeh Z, Qipo A, Fan Z, Hanidziar D, Putheti P, Shi H, Csizuadia E, Libermann TA, Strom TB. The role of TNF-a in mice with type 1- and 2- diabetes. PLoS One. 2012; 7(5):e33254.
    View in: PubMed
  12. Koulmanda M, Qipo A, Fan Z, Smith N, Auchincloss H, Zheng XX, Strom TB. Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term triple therapy. Am J Transplant. 2012 May; 12(5):1296-302.
    View in: PubMed
  13. Millington T, Koulmanda M, Ng C, Boskovic S, Nadazdin OM, Benichou G, Zheng XX, Strom TB, Madsen JC. Effects of an agonist interleukin-2/Fc fusion protein, a mutant antagonist interleukin-15/Fc fusion protein, and sirolimus on cardiac allograft survival in non-human primates. J Heart Lung Transplant. 2012 Apr; 31(4):427-35.
    View in: PubMed
  14. Balasubramanian S, Jansen M, Valerius MT, Humphreys BD, Strom TB. Orphan nuclear receptor Nur77 promotes acute kidney injury and renal epithelial apoptosis. J Am Soc Nephrol. 2012 Apr; 23(4):674-86.
    View in: PubMed
  15. Yamada Y, Boskovic S, Aoyama A, Murakami T, Putheti P, Smith RN, Ochiai T, Nadazdin O, Koyama I, Boenisch O, Najafian N, Bhasin MK, Colvin RB, Madsen JC, Strom TB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Overcoming memory T-cell responses for induction of delayed tolerance in nonhuman primates. Am J Transplant. 2012 Feb; 12(2):330-40.
    View in: PubMed
  16. Fujisaki J, Wu J, Carlson AL, Silberstein L, Putheti P, Larocca R, Gao W, Saito TI, Lo Celso C, Tsuyuzaki H, Sato T, Côté D, Sykes M, Strom TB, Scadden DT, Lin CP. In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature. 2011 Jun 9; 474(7350):216-9.
    View in: PubMed
  17. Gupta S, Balasubramanian S, Thornley TB, Strom TB, Kenny JJ. Direct pathway T-cell alloactivation is more rapid than indirect pathway alloactivation. Transplantation. 2011 May 15; 91(9):e65-7.
    View in: PubMed
  18. El Essawy B, Putheti P, Gao W, Strom TB. Rapamycin generates graft-homing murine suppressor CD8(+) T cells that confer donor-specific graft protection. Cell Transplant. 2011; 20(11-12):1759-69.
    View in: PubMed
  19. Park J, Gao W, Whiston R, Strom TB, Metcalfe S, Fahmy TM. Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery. Mol Pharm. 2011 Feb 7; 8(1):143-52.
    View in: PubMed
  20. Hanidziar D, Koulmanda M, Strom TB. Creating transplant tolerance by taming adverse intragraft innate immunity. F1000 Biol Rep. 2010; 2:83.
    View in: PubMed
  21. Sánchez-Fueyo A, Strom TB. Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs. Gastroenterology. 2011 Jan; 140(1):51-64.
    View in: PubMed
  22. Dwyer KM, Hanidziar D, Putheti P, Hill PA, Pommey S, McRae JL, Winterhalter A, Doherty G, Deaglio S, Koulmanda M, Gao W, Robson SC, Strom TB. Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype. Am J Transplant. 2010 Nov; 10(11):2410-20.
    View in: PubMed
  23. Kirk A, Strom TB. Immunogenetics and transplantation. Curr Opin Immunol. 2010 Oct; 22(5):631-3.
    View in: PubMed
  24. Koulmanda M, Strom TB. T-cell-directed treatment strategies for Type 1 diabetes and the confounding role of inflammation. Immunotherapy. 2010 Jul; 2(4):431-6.
    View in: PubMed
  25. Fan Z, Spencer JA, Lu Y, Pitsillides CM, Singh G, Kim P, Yun SH, Toxavidis V, Strom TB, Lin CP, Koulmanda M. In vivo tracking of 'color-coded' effector, natural and induced regulatory T cells in the allograft response. Nat Med. 2010 Jun; 16(6):718-22.
    View in: PubMed
  26. Bodonyi-Kovacs G, Putheti P, Marino M, Avihingsanon Y, Uknis ME, Monaco AP, Strom TB, Pavlakis M. Gene expression profiling of the donor kidney at the time of transplantation predicts clinical outcomes 2 years after transplantation. Hum Immunol. 2010 May; 71(5):451-5.
    View in: PubMed
  27. Putheti P, Awasthi A, Popoola J, Gao W, Strom TB. Human CD4 memory T cells can become CD4+IL-9+ T cells. PLoS One. 2010; 5(1):e8706.
    View in: PubMed
  28. Kang HG, Lee JE, Yang SH, Lee SH, Gao W, Strom TB, Oh K, Lee DS, Kim YS. Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens. Immunology. 2010 Apr; 129(4):567-77.
    View in: PubMed
  29. Hastings WD, Anderson DE, Kassam N, Koguchi K, Greenfield EA, Kent SC, Zheng XX, Strom TB, Hafler DA, Kuchroo VK. TIM-3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines. Eur J Immunol. 2009 Sep; 39(9):2492-501.
    View in: PubMed
  30. Strom TB, Koulmanda M. Recently discovered T cell subsets cannot keep their commitments. J Am Soc Nephrol. 2009 Aug; 20(8):1677-80.
    View in: PubMed
  31. Zhou Q, Yan J, Putheti P, Wu Y, Sun X, Toxavidis V, Tigges J, Kassam N, Enjyoji K, Robson SC, Strom TB, Gao W. Isolated CD39 expression on CD4+ T cells denotes both regulatory and memory populations. Am J Transplant. 2009 Oct; 9(10):2303-11.
    View in: PubMed
  32. Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, Beckhove P, Gounari F, Khazaie K. T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res. 2009 Jul 1; 69(13):5490-7.
    View in: PubMed
  33. Strom TB. Can childhood viral infection protect from type 1 diabetes? J Clin Invest. 2009 Jun; 119(6):1458-61.
    View in: PubMed
  34. Mariat C, Degauque N, Strom TB. TIM-1: a new player in transplant immunity. Transplantation. 2009 May 15; 87(9 Suppl):S84-6.
    View in: PubMed
  35. Gao W, Thompson L, Zhou Q, Putheti P, Fahmy TM, Strom TB, Metcalfe SM. Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6. Cell Cycle. 2009 May 1; 8(9):1444-50.
    View in: PubMed
  36. Mariat C, Degauque N, Balasubramanian S, Kenny J, DeKruyff RH, Umetsu DT, Kuchroo V, Zheng XX, Strom TB. Tim-1 signaling substitutes for conventional signal 1 and requires costimulation to induce T cell proliferation. J Immunol. 2009 Feb 1; 182(3):1379-85.
    View in: PubMed
  37. Dardalhon V, Awasthi A, Kwon H, Galileos G, Gao W, Sobel RA, Mitsdoerffer M, Strom TB, Elyaman W, Ho IC, Khoury S, Oukka M, Kuchroo VK. IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells. Nat Immunol. 2008 Dec; 9(12):1347-55.
    View in: PubMed
  38. Strom TB, Koulmanda M. Cytokine related therapies for autoimmune disease. Curr Opin Immunol. 2008 Dec; 20(6):676-81.
    View in: PubMed
  39. Koulmanda M, Bhasin M, Hoffman L, Fan Z, Qipo A, Shi H, Bonner-Weir S, Putheti P, Degauque N, Libermann TA, Auchincloss H, Flier JS, Strom TB. Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A. 2008 Oct 21; 105(42):16242-7.
    View in: PubMed
  40. Feng G, Gao W, Strom TB, Oukka M, Francis RS, Wood KJ, Bushell A. Exogenous IFN-gamma ex vivo shapes the alloreactive T-cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cells. Eur J Immunol. 2008 Sep; 38(9):2512-27.
    View in: PubMed
  41. Porrett PM, Yuan X, LaRosa DF, Walsh PT, Yang J, Gao W, Li P, Zhang J, Ansari JM, Hancock WW, Sayegh MH, Koulmanda M, Strom TB, Turka LA. Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol. 2008 Aug 1; 181(3):1692-9.
    View in: PubMed
  42. Tzianabos AO, Holsti MA, Zheng XX, Stucchi AF, Kuchroo VK, Strom TB, Glimcher LH, Cruikshank WW. Functional Th1 cells are required for surgical adhesion formation in a murine model. J Immunol. 2008 May 15; 180(10):6970-6.
    View in: PubMed
  43. Rodriguez-Manzanet R, Meyers JH, Balasubramanian S, Slavik J, Kassam N, Dardalhon V, Greenfield EA, Anderson AC, Sobel RA, Hafler DA, Strom TB, Kuchroo VK. TIM-4 expressed on APCs induces T cell expansion and survival. J Immunol. 2008 Apr 1; 180(7):4706-13.
    View in: PubMed
  44. Muthukumarana PA, Zheng XX, Rosengard BR, Strom TB, Metcalfe SM. In primed allo-tolerance, TIM-3-Ig rapidly suppresses TGFbeta, but has no immediate effect on Foxp3. Transpl Int. 2008 Jun; 21(6):593-7.
    View in: PubMed
  45. Degauque N, Mariat C, Kenny J, Zhang D, Gao W, Vu MD, Alexopoulos S, Oukka M, Umetsu DT, DeKruyff RH, Kuchroo V, Zheng XX, Strom TB. Immunostimulatory Tim-1-specific antibody deprograms Tregs and prevents transplant tolerance in mice. J Clin Invest. 2008 Feb; 118(2):735-41.
    View in: PubMed
  46. Strom TB. 2006 Homer W. Smith Lecture: taming T cells. J Am Soc Nephrol. 2007 Nov; 18(11):2824-32.
    View in: PubMed
  47. Zhong X, Gao W, Degauque N, Bai C, Lu Y, Kenny J, Oukka M, Strom TB, Rothstein TL. Reciprocal generation of Th1/Th17 and T(reg) cells by B1 and B2 B cells. Eur J Immunol. 2007 Sep; 37(9):2400-4.
    View in: PubMed
  48. Koulmanda M, Budo E, Bonner-Weir S, Qipo A, Putheti P, Degauque N, Shi H, Fan Z, Flier JS, Auchincloss H, Zheng XX, Strom TB. Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A. 2007 Aug 7; 104(32):13074-9.
    View in: PubMed
  49. Degauque N, Mariat C, Kenny J, Sanchez-Fueyo A, Alexopoulos SP, Kuchroo V, Zheng XX, Strom TB. Regulation of T-cell immunity by T-cell immunoglobulin and mucin domain proteins. Transplantation. 2007 Jul 15; 84(1 Suppl):S12-6.
    View in: PubMed
  50. Xiao S, Najafian N, Reddy J, Albin M, Zhu C, Jensen E, Imitola J, Korn T, Anderson AC, Zhang Z, Gutierrez C, Moll T, Sobel RA, Umetsu DT, Yagita H, Akiba H, Strom T, Sayegh MH, DeKruyff RH, Khoury SJ, Kuchroo VK. Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function. J Exp Med. 2007 Jul 9; 204(7):1691-702.
    View in: PubMed
  51. Korn T, Bettelli E, Gao W, Awasthi A, Jäger A, Strom TB, Oukka M, Kuchroo VK. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature. 2007 Jul 26; 448(7152):484-7.
    View in: PubMed
  52. Gao W, Lu Y, El Essawy B, Oukka M, Kuchroo VK, Strom TB. Contrasting effects of cyclosporine and rapamycin in de novo generation of alloantigen-specific regulatory T cells. Am J Transplant. 2007 Jul; 7(7):1722-32.
    View in: PubMed
  53. Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, Chen JF, Enjyoji K, Linden J, Oukka M, Kuchroo VK, Strom TB, Robson SC. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med. 2007 Jun 11; 204(6):1257-65.
    View in: PubMed
  54. Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, Bäckström BT, Sobel RA, Wucherpfennig KW, Strom TB, Oukka M, Kuchroo VK. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med. 2007 Apr; 13(4):423-31.
    View in: PubMed
  55. Sánchez-Fueyo A, Domenig CM, Mariat C, Alexopoulos S, Zheng XX, Strom TB. Influence of direct and indirect allorecognition pathways on CD4+CD25+ regulatory T-cell function in transplantation. Transpl Int. 2007 Jun; 20(6):534-41.
    View in: PubMed
  56. Koyama I, Nadazdin O, Boskovic S, Ochiai T, Smith RN, Sykes M, Sogawa H, Murakami T, Strom TB, Colvin RB, Sachs DH, Benichou G, Cosimi AB, Kawai T. Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft. Am J Transplant. 2007 May; 7(5):1055-61.
    View in: PubMed
  57. Dwyer KM, Deaglio S, Gao W, Friedman D, Strom TB, Robson SC. CD39 and control of cellular immune responses. Purinergic Signal. 2007 Mar; 3(1-2):171-80.
    View in: PubMed
  58. Ferrari-Lacraz S, Zheng XX, Fueyo AS, Maslinski W, Moll T, Strom TB. CD8(+) T cells resistant to costimulatory blockade are controlled by an antagonist interleukin-15/Fc protein. Transplantation. 2006 Dec 15; 82(11):1510-7.
    View in: PubMed
  59. Kim YS, Yang SH, Kang HG, Seong EY, Lee SH, Gao W, Kenny J, Zheng XX, Strom TB. Distinctive role of donor strain immature dendritic cells in the creation of allograft tolerance. Int Immunol. 2006 Dec; 18(12):1771-7.
    View in: PubMed
  60. Boskovic S, Kawai T, Smith RN, Wee SL, Nadazdin O, Koyama I, Saidman S, Cardarelli F, Elias N, Sykes M, Strom T, Colvin RB, Sachs DH, Cosimi AB. Monitoring antidonor alloantibodies as a predictive assay for renal allograft tolerance/long-term observations in nonhuman primates. Transplantation. 2006 Sep 27; 82(6):819-25.
    View in: PubMed
  61. Lu LF, Lind EF, Gondek DC, Bennett KA, Gleeson MW, Pino-Lagos K, Scott ZA, Coyle AJ, Reed JL, Van Snick J, Strom TB, Zheng XX, Noelle RJ. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature. 2006 Aug 31; 442(7106):997-1002.
    View in: PubMed
  62. El Essawy B, Otu HH, Choy B, Zheng XX, Libermann TA, Strom TB. Proteomic analysis of the allograft response. Transplantation. 2006 Jul 27; 82(2):267-74.
    View in: PubMed
  63. Papathanassoglou E, El-Haschimi K, Li XC, Matarese G, Strom T, Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol. 2006 Jun 15; 176(12):7745-52.
    View in: PubMed
  64. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006 May 11; 441(7090):235-8.
    View in: PubMed
  65. Koulmanda M, Smith RN, Qipo A, Weir G, Auchincloss H, Strom TB. Prolonged survival of allogeneic islets in cynomolgus monkeys after short-term anti-CD154-based therapy: nonimmunologic graft failure? Am J Transplant. 2006 Apr; 6(4):687-96.
    View in: PubMed
  66. Strom TB, Suthanthiran M. Transcriptional profiling to assess the clinical status of kidney transplants. Nat Clin Pract Nephrol. 2006 Mar; 2(3):116-7.
    View in: PubMed
  67. Zheng XX, Gao W, Donskoy E, Neuberg M, Ruediger M, Strom TB, Moll T. An antagonist mutant IL-15/Fc promotes transplant tolerance. Transplantation. 2006 Jan 15; 81(1):109-16.
    View in: PubMed
  68. Sánchez-Fueyo A, Sandner S, Habicht A, Mariat C, Kenny J, Degauque N, Zheng XX, Strom TB, Turka LA, Sayegh MH. Specificity of CD4+CD25+ regulatory T cell function in alloimmunity. J Immunol. 2006 Jan 1; 176(1):329-34.
    View in: PubMed
  69. Strom TB. Rejection--more than the eye can see. N Engl J Med. 2005 Dec 1; 353(22):2394-6.
    View in: PubMed
  70. Zhu C, Anderson AC, Schubart A, Xiong H, Imitola J, Khoury SJ, Zheng XX, Strom TB, Kuchroo VK. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol. 2005 Dec; 6(12):1245-52.
    View in: PubMed
  71. Mariat C, Sánchez-Fueyo A, Alexopoulos SP, Kenny J, Strom TB, Zheng XX. Regulation of T cell dependent immune responses by TIM family members. Philos Trans R Soc Lond B Biol Sci. 2005 Sep 29; 360(1461):1681-5.
    View in: PubMed
  72. Sho M, Kishimoto K, Harada H, Livak M, Sanchez-Fueyo A, Yamada A, Zheng XX, Strom TB, Basadonna GP, Sayegh MH, Rothstein DM. Requirements for induction and maintenance of peripheral tolerance in stringent allograft models. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13230-5.
    View in: PubMed
  73. Strom TB. Saving islets from allograft rejection. Proc Natl Acad Sci U S A. 2005 Sep 6; 102(36):12651-2.
    View in: PubMed
  74. Chakravarti S, Sabatos CA, Xiao S, Illes Z, Cha EK, Sobel RA, Zheng XX, Strom TB, Kuchroo VK. Tim-2 regulates T helper type 2 responses and autoimmunity. J Exp Med. 2005 Aug 1; 202(3):437-44.
    View in: PubMed
  75. Domenig C, Sanchez-Fueyo A, Kurtz J, Alexopoulos SP, Mariat C, Sykes M, Strom TB, Zheng XX. Roles of deletion and regulation in creating mixed chimerism and allograft tolerance using a nonlymphoablative irradiation-free protocol. J Immunol. 2005 Jul 1; 175(1):51-60.
    View in: PubMed
  76. Strom TB. Measurements of protective genes in allograft rejection. 2005.
  77. Avihingsanon Y, Ma N, Pavlakis M, Chon WJ, Uknis ME, Monaco AP, Ferran C, Stillman I, Schachter AD, Mottley C, Zheng XX, Strom TB. On the intraoperative molecular status of renal allografts after vascular reperfusion and clinical outcomes. J Am Soc Nephrol. 2005 Jun; 16(6):1542-8.
    View in: PubMed
  78. Meyers JH, Chakravarti S, Schlesinger D, Illes Z, Waldner H, Umetsu SE, Kenny J, Zheng XX, Umetsu DT, DeKruyff RH, Strom TB, Kuchroo VK. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nat Immunol. 2005 May; 6(5):455-64.
    View in: PubMed
  79. Vu MD, Li Y, Strom TB, Li XC. Mycophenolate mofetil is compatible with CD28/CD154 costimulatory blockade in preventing transplant rejection. Transplantation. 2005 Mar 27; 79(6):736.
    View in: PubMed
  80. McDaid J, Yamashita K, Chora A, Ollinger R, Strom TB, Li XC, Bach FH, Soares MP. Heme oxygenase-1 modulates the allo-immune response by promoting activation-induced cell death of T cells. FASEB J. 2005 Mar; 19(3):458-60.
    View in: PubMed
  81. Hartt Meyers J, Chakravarti S, Schlesinger D, Illes Z, Waldne H, Kenny J, Zheng XX, Umetsu DT, DeKruyff RH, Strom TB, Kuchroo VK. Tim-4 is the ligand for Tim-1, and the Tim-1/Tim-4 interaction regulates the development of Th2 responses. Natl Immunol. 2005; 6:455-64.
  82. Sánchez-Fueyo A, Strom TB. Immunological tolerance and liver transplantation. J Hepatol. 2004 Nov; 41(5):698-705.
    View in: PubMed
  83. Ferrari-Lacraz S, Zanelli E, Neuberg M, Donskoy E, Kim YS, Zheng XX, Hancock WW, Maslinski W, Li XC, Strom TB, Moll T. Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol. 2004 Nov 1; 173(9):5818-26.
    View in: PubMed
  84. Strom TB, Maslinski W, Zheng XX, Kim YS, Ferrari-Lacraz S. Components and methods for achieving immune suppression. 2004.
  85. Zhong X, Bai C, Gao W, Strom TB, Rothstein TL. Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger. Int Immunol. 2004 Aug; 16(8):1181-8.
    View in: PubMed
  86. Strom TB. Is transplantation tolerable? J Clin Invest. 2004 Jun; 113(12):1681-3.
    View in: PubMed
  87. Hleb M, Murphy S, Wagner EF, Hanna NN, Sharma N, Park J, Li XC, Strom TB, Padbury JF, Tseng YT, Sharma S. Evidence for cyclin D3 as a novel target of rapamycin in human T lymphocytes. J Biol Chem. 2004 Jul 23; 279(30):31948-55.
    View in: PubMed
  88. Strom TB, Field LJ, Ruediger M. Allogeneic stem cell-derived "repair unit" therapy and the barriers to clinical deployment. J Am Soc Nephrol. 2004 May; 15(5):1133-9.
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  89. Ricordi C, Strom TB. Clinical islet transplantation: advances and immunological challenges. Nat Rev Immunol. 2004 Apr; 4(4):259-68.
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  90. Demirci G, Amanullah F, Kewalaramani R, Yagita H, Strom TB, Sayegh MH, Li XC. Critical role of OX40 in CD28 and CD154-independent rejection. J Immunol. 2004 Feb 1; 172(3):1691-8.
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  91. Walsh PT, Strom TB, Turka LA. Routes to transplant tolerance versus rejection; the role of cytokines. Immunity. 2004 Feb; 20(2):121-31.
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  92. Zheng XX, Sanchez-Fueyo A, Domenig C, Strom TB. The balance of deletion and regulation in allograft tolerance. Immunol Rev. 2003 Dec; 196:75-84.
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  93. Jarvinen LZ, Blazar BR, Adeyi OA, Strom TB, Noelle RJ. CD154 on the surface of CD4+CD25+ regulatory T cells contributes to skin transplant tolerance. Transplantation. 2003 Nov 15; 76(9):1375-9.
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  94. Sabatos CA, Chakravarti S, Cha E, Schubart A, Sánchez-Fueyo A, Zheng XX, Coyle AJ, Strom TB, Freeman GJ, Kuchroo VK. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat Immunol. 2003 Nov; 4(11):1102-10.
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  95. Sánchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutiérrez-Ramos JC, Coyle AJ, Strom TB. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat Immunol. 2003 Nov; 4(11):1093-101.
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  96. Tang Q, Henriksen KJ, Boden EK, Tooley AJ, Ye J, Subudhi SK, Zheng XX, Strom TB, Bluestone JA. Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol. 2003 Oct 1; 171(7):3348-52.
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  97. Zheng XX, Sánchez-Fueyo A, Sho M, Domenig C, Sayegh MH, Strom TB. Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity. 2003 Oct; 19(4):503-14.
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  98. Demirci G, Strom TB, Li XC. Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms. J Immunol. 2003 Oct 1; 171(7):3878-85.
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  99. Gao W, Demirci G, Strom TB, Li XC. Stimulating PD-1-negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival. Transplantation. 2003 Sep 27; 76(6):994-9.
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  100. Quezada SA, Fuller B, Jarvinen LZ, Gonzalez M, Blazar BR, Rudensky AY, Strom TB, Noelle RJ. Mechanisms of donor-specific transfusion tolerance: preemptive induction of clonal T-cell exhaustion via indirect presentation. Blood. 2003 Sep 1; 102(5):1920-6.
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  101. Strom TB, Sukhatme VP. A refined understanding of immunosuppressives and cancer risk. Kidney Int. 2003 Mar; 63(3):1160-1.
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  102. Zheng XX, Maslinski W, Ferrari-Lacraz S, Strom TB. Cytokines in the treatment and prevention of autoimmune responses-a role of IL-15. Adv Exp Med Biol. 2003; 520:87-95.
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  103. Sho M, Yamada A, Najafian N, Salama AD, Harada H, Sandner SE, Sanchez-Fueyo A, Zheng XX, Strom TB, Sayegh MH. Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size. J Immunol. 2002 Oct 1; 169(7):3744-51.
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  104. Strom TB, Field LJ, Ruediger M. Allogeneic stem cells, clinical transplantation and the origins of regenerative medicine. Curr Opin Immunol. 2002 Oct; 14(5):601-5.
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  105. Sánchez-Fueyo A, Domenig C, Strom TB, Zheng XX. The complement dependent cytotoxicity (CDC) immune effector mechanism contributes to anti-CD154 induced immunosuppression. Transplantation. 2002 Sep 27; 74(6):898-900.
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  106. Kurowska M, Rudnicka W, Kontny E, Janicka I, Chorazy M, Kowalczewski J, Ziólkowska M, Ferrari-Lacraz S, Strom TB, Maslinski W. Fibroblast-like synoviocytes from rheumatoid arthritis patients express functional IL-15 receptor complex: endogenous IL-15 in autocrine fashion enhances cell proliferation and expression of Bcl-x(L) and Bcl-2. J Immunol. 2002 Aug 15; 169(4):1760-7.
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  107. Strom TB. Chimeric IL-10 proteins and uses thereof. 2002.
  108. Kishimoto K, Sandner S, Imitola J, Sho M, Li Y, Langmuir PB, Rothstein DM, Strom TB, Turka LA, Sayegh MH. Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance. J Clin Invest. 2002 Jun; 109(11):1471-9.
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  109. Demirci G, Gao W, Zheng XX, Malek TR, Strom TB, Li XC. On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response. J Immunol. 2002 May 1; 168(9):4382-90.
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  110. Ferrari-Lacraz S, Zheng XX, Kim YS, Maslinski W, Strom TB. Addition of an IL-15 mutant/FCgamma2A antagonist protein protects islet allografts from rejection overriding costimulation blockade. Transplant Proc. 2002 May; 34(3):745-7.
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  111. Avihingsanon Y, Ma N, Csizmadia E, Wang C, Pavlakis M, Giraldo M, Strom TB, Soares MP, Ferran C. Expression of protective genes in human renal allografts: a regulatory response to injury associated with graft rejection. Transplantation. 2002 Apr 15; 73(7):1079-85.
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  112. Sánchez-Fueyo A, Weber M, Domenig C, Strom TB, Zheng XX. Tracking the immunoregulatory mechanisms active during allograft tolerance. J Immunol. 2002 Mar 1; 168(5):2274-81.
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  113. Strehlau J, Schachter AD, Pavlakis M, Singh A, Tejani A, Strom TB. Activated intrarenal transcription of CTL-effectors and TGF-beta1 in children with focal segmental glomerulosclerosis. Kidney Int. 2002 Jan; 61(1):90-5.
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  114. Shulzhenko N, Morgun A, Zheng XX, Diniz RV, Almeida DR, Ma N, Strom TB, Gerbase-DeLima M. Intragraft activation of genes encoding cytotoxic T lymphocyte effector molecules precedes the histological evidence of rejection in human cardiac transplantation. Transplantation. 2001 Nov 27; 72(10):1705-8.
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  115. Li XC, Wells AD, Turka LA, Strom TB. Death of alloreactive T cells sets the stage for immunoregulation to act. Transplant Proc. 2001 Nov-Dec; 33(7-8):3041-3.
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  116. Strom TB, Field LJ, Ruediger M. Allogeneic stem cells, clinical transplantation, and the origins of regenerative medicine. Transplant Proc. 2001 Nov-Dec; 33(7-8):3044-9.
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  117. Ferrari-Lacraz S, Zheng XX, Kim YS, Li Y, Maslinski W, Li XC, Strom TB. An antagonist IL-15/Fc protein prevents costimulation blockade-resistant rejection. J Immunol. 2001 Sep 15; 167(6):3478-85.
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  118. Schnipper LE, Strom TB. A magic bullet for cancer--how near and how far? N Engl J Med. 2001 Jul 26; 345(4):283-4.
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  119. Craiu A, Barouch DH, Zheng XX, Kuroda MJ, Schmitz JE, Lifton MA, Steenbeke TD, Nickerson CE, Beaudry K, Frost JD, Reimann KA, Strom TB, Letvin NL. An IL-2/Ig fusion protein influences CD4+ T lymphocytes in naive and simian immunodeficiency virus-infected Rhesus monkeys. AIDS Res Hum Retroviruses. 2001 Jul 1; 17(10):873-86.
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  120. Wells AD, Li XC, Strom TB, Turka LA. The role of peripheral T-cell deletion in transplantation tolerance. Philos Trans R Soc Lond B Biol Sci. 2001 May 29; 356(1409):617-23.
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  121. Wasowska BA, Zheng XX, Strom TB, Kupieck-Weglinski JW. Adjunctive rapamycin and CsA treatment inhibits monocyte/macrophage associated cytokines/chemokines in sensitized cardiac graft recipients. Transplantation. 2001 Apr 27; 71(8):1179-83.
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  122. Li XC, Strom TB, Turka LA, Wells AD. T cell death and transplantation tolerance. Immunity. 2001 Apr; 14(4):407-16.
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  123. Strom TB, Vascncellos, Suthanthiran M,. Methods of evaluating transplant rejection. 2001.
  124. Emmanuilidis K, Weighardt H, Fleischmann T, Gerauer K, Maier S, Zheng XX, Strom TB, Hancock WW, Holzmann B, Heidecke CD. Critical role of Kupffer cell-derived IL-10 for host defense in septic peritonitis. J Immunol. 2001; 167:3919.
  125. Li XC, Demirci G, Ferrari-Lacraz S, Groves C, Coyle A, Malek TR, Strom TB. IL-15 and IL-2: a matter of life and death for T cells in vivo. Nat Med. 2001 Jan; 7(1):114-8.
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  126. Strom TB, Zheng XX. Fusion proteins with an immunoglobulin hinge region linker. 2000.
  127. Zand MS, Li Y, Hancock W, Li XC, Roy-Chaudhury P, Zheng XX, Strom TB. Interleukin-2 and interferon-gamma double knockout mice reject heterotopic cardiac allografts. Transplantation. 2000 Nov 15; 70(9):1378-81.
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  128. Bristol IJ, Farmer MA, Cong Y, Zheng XX, Strom TB, Elson CO, Sundberg JP, Leiter EH. Heritable susceptibility for colitis in mice induced by IL-10 deficiency. Inflamm Bowel Dis. 2000 Nov; 6(4):290-302.
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  129. Barouch DH, Santra S, Schmitz JE, Kuroda MJ, Fu TM, Wagner W, Bilska M, Craiu A, Zheng XX, Krivulka GR, Beaudry K, Lifton MA, Nickerson CE, Trigona WL, Punt K, Freed DC, Guan L, Dubey S, Casimiro D, Simon A, Davies ME, Chastain M, Strom TB, Gelman RS, Montefiori DC, Lewis MG, Emini EA, Shiver JW, Letvin NL. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science. 2000 Oct 20; 290(5491):486-92.
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  130. Schachter AD, Strehlau J, Zurakowski D, Vasconcellos L, Kim YS, Zheng XX, Gunshin Y, Overstreet SL, Benfield MR, Tejani A, Harmon WE, Herrin JT, Strom TB. Increased nuclear factor-kappaB and angiotensinogen gene expression in posttransplant recurrent focal segmental glomerulosclerosis. Transplantation. 2000 Oct 15; 70(7):1107-10.
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  131. Dodge IL, Demirci G, Strom TB, Li XC. Rapamycin induces transforming growth factor-beta production by lymphocytes. Transplantation. 2000 Oct 15; 70(7):1104-6.
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  132. Li XC, Wells AD, Strom TB, Turka LA. The role of T cell apoptosis in transplantation tolerance. Curr Opin Immunol. 2000 Oct; 12(5):522-7.
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  133. Hrabé de Angelis MH, Flaswinkel H, Fuchs H, Rathkolb B, Soewarto D, Marschall S, Heffner S, Pargent W, Wuensch K, Jung M, Reis A, Richter T, Alessandrini F, Jakob T, Fuchs E, Kolb H, Kremmer E, Schaeble K, Rollinski B, Roscher A, Peters C, Meitinger T, Strom T, Steckler T, Holsboer F, Klopstock T, Gekeler F, Schindewolf C, Jung T, Avraham K, Behrendt H, Ring J, Zimmer A, Schughart K, Pfeffer K, Wolf E, Balling R. Genome-wide, large-scale production of mutant mice by ENU mutagenesis. Nat Genet. 2000 Aug; 25(4):444-7.
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  134. Li XC, Strom TB. A rare find - cells that improve bone marrow transplantation. Nat Med. 2000 Aug; 6(8):866-7.
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  135. Barouch DH, Craiu A, Kuroda MJ, Schmitz JE, Zheng XX, Santra S, Frost JD, Krivulka GR, Lifton MA, Crabbs CL, Heidecker G, Perry HC, Davies ME, Xie H, Nickerson CE, Steenbeke TD, Lord CI, Montefiori DC, Strom TB, Shiver JW, Lewis MG, Letvin NL. Augmentation of immune responses to HIV-1 and simian immunodeficiency virus DNA vaccines by IL-2/Ig plasmid administration in rhesus monkeys. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4192-7.
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  136. Strom TB, Suthanthiran M. Prospects and applicability of molecular diagnosis of allograft rejection. Semin Nephrol. 2000 Mar; 20(2):103-7.
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  137. Li XC, Ima A, Li Y, Zheng XX, Malek TR, Strom TB. Blocking the common gamma-chain of cytokine receptors induces T cell apoptosis and long-term islet allograft survival. J Immunol. 2000 Feb 1; 164(3):1193-9.
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  138. Li Y, Strom TB. Reply to failure of combined costimulatory blockade in animal transplant model Nat Med. 2000 Feb; 6(2):115.
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  139. Li XC, Strom TB. Blocking T-cell costimulation in transplantation: opportunities and challenges. Transfusion. 2000 Feb; 40(2):139-42.
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  140. Feng X, Zheng XX, Yi S, Lehnert AM, Strom TB, O'Connell PJ. IL-10/Fc inhibits macrophage function and prolongs pancreatic islet xenograft survival. Transplantation. 1999 Dec 15; 68(11):1775-83.
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  141. McKay DB, Irie HY, Hollander G, Ferrara JL, Strom TB, Li Y, Burakoff SJ. Antigen-induced unresponsiveness results in altered T cell signaling. J Immunol. 1999 Dec 15; 163(12):6455-61.
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  142. Strom TB, Maslinski W,. Antagonists of interleukin-15. 1999.
  143. Wells AD, Li XC, Li Y, Walsh MC, Zheng XX, Wu Z, Nuñez G, Tang A, Sayegh M, Hancock WW, Strom TB, Turka LA. Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance. Nat Med. 1999 Nov; 5(11):1303-7.
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  144. Li Y, Li XC, Zheng XX, Wells AD, Turka LA, Strom TB. Blocking both signal 1 and signal 2 of T-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med. 1999 Nov; 5(11):1298-302.
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  145. Hendry WS, Tilney NL, Baldwin WM, Graves MJ, Milford E, Strom TB, Carpenter CB. Transfer of specific unresponsiveness to organ allografts by thymocytes. J Am Soc Nephrol. 1999 Nov; 10(11):2454-63.
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  146. Neylan JF, Sayegh MH, Coffman TM, Danovitch GM, Krensky AM, Strom TB, Turka LA, Harmon WE. The allocation of cadaver kidneys for transplantation in the United States: consensus and controversy. ASN Transplant Advisory Group. American Society of Nephrology. J Am Soc Nephrol. 1999 Oct; 10(10):2237-43.
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  147. Zheng XX, Steele AW, Hancock WW, Kawamoto K, Li XC, Nickerson PW, Li Y, Tian Y, Strom TB. IL-2 receptor-targeted cytolytic IL-2/Fc fusion protein treatment blocks diabetogenic autoimmunity in nonobese diabetic mice. J Immunol. 1999 Oct 1; 163(7):4041-8.
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  148. Strom TB. Methods and compounds for prevention of graft rejection. 1999.
  149. Li XC, Li Y, Dodge I, Wells AD, Zheng XX, Turka LA, Strom TB. Induction of allograft tolerance in the absence of Fas-mediated apoptosis. J Immunol. 1999 Sep 1; 163(5):2500-7.
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  150. Carrié A, Jun L, Bienvenu T, Vinet MC, McDonell N, Couvert P, Zemni R, Cardona A, Van Buggenhout G, Frints S, Hamel B, Moraine C, Ropers HH, Strom T, Howell GR, Whittaker A, Ross MT, Kahn A, Fryns JP, Beldjord C, Marynen P, Chelly J. A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation. Nat Genet. 1999 Sep; 23(1):25-31.
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  151. Wieder KJ, Strom TB. Gene encoding mutant L33T4 protein which facilitates HIV infection and transgenic mouse expressing such protein. 1999.
  152. Filisetti D, Ostermann G, von Bredow M, Strom T, Filler G, Ehrich J, Pannetier S, Garnier JM, Rowe P, Francis F, Julienne A, Hanauer A, Econs MJ, Oudet C. Non-random distribution of mutations in the PHEX gene, and under-detected missense mutations at non-conserved residues. Eur J Hum Genet. 1999 Jul; 7(5):615-9.
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  153. Strom TB. Use of interleukin-2 (IL-2) receptor-specific agents to treat allograft rejection. 1999.
  154. Zheng XX, Markees TG, Hancock WW, Li Y, Greiner DL, Li XC, Mordes JP, Sayegh MH, Rossini AA, Strom TB. CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment. J Immunol. 1999 Apr 15; 162(8):4983-90.
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  155. Li XC, Zheng XX, Strom TB. T-cell growth factors in allograft rejection and tolerance. Transplant Proc. 1999 Feb-Mar; 31(1-2):342-3.
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  156. Zheng XX, Li Y, Li XC, Roy-Chaudhury P, Nickerson P, Tian Y, Sayegh MH, Strom TB. Blockade of CD40L/CD40 costimulatory pathway in a DST presensitization model of islet allograft leads to a state of Allo-Ag specific tolerance and permits subsequent engraftment of donor strain islet or heart allografts. Transplant Proc. 1999 Feb-Mar; 31(1-2):627-8.
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  157. Schachter AD, Strom TB. Posttransplant recurrent FSGS: molecular insights and future directions. Nephron. 1999; 82(4):300-5.
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  158. Kim YS, Maslinski W, Zheng XX, Schachter AD, Strom TB. Immunoglobulin-cytokine fusion molecules: the new generation of immunomodulating agents. Transplant Proc. 1998 Dec; 30(8):4031-6.
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  159. Li Y, Zheng XX, Li XC, Zand MS, Strom TB. Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftment. Transplantation. 1998 Nov 27; 66(10):1387-8.
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  160. Vasconcellos LM, Schachter AD, Zheng XX, Vasconcellos LH, Shapiro M, Harmon WE, Strom TB, Schachter D. Cytotoxic lymphocyte gene expression in peripheral blood leukocytes correlates with rejecting renal allografts. Transplantation. 1998 Sep 15; 66(5):562-6.
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  161. Li XC, Zand MS, Li Y, Zheng XX, Strom TB. On histocompatibility barriers, Th1 to Th2 immune deviation, and the nature of the allograft responses. J Immunol. 1998 Sep 1; 161(5):2241-7.
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  162. Barouch DH, Santra S, Steenbeke TD, Zheng XX, Perry HC, Davies ME, Freed DC, Craiu A, Strom TB, Shiver JW, Letvin NL. Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration. J Immunol. 1998 Aug 15; 161(4):1875-82.
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  163. Strehlau J, Maslinski W, Chae D, Pavlakis M, Ehrich JH, Strom TB. Adjusting immunosuppression to the identification of T-cell activating mediators in rejecting transplants: a novel approach to rejection diagnosis and treatment. Transplant Proc. 1998 Aug; 30(5):2389-91.
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  164. Ding R, Li B, Sharma VK, Bologa RM, Lagman M, Mouradian J, Strom TB, Suthanthiran M. Quantitative competitive polymerase chain reaction: design and synthesis of mRNA-specific competitor DNA templates and their clinical usage. Transplant Proc. 1998 Aug; 30(5):2370-2.
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  165. Sharma VK, Ding R, Li B, Bologa RM, Lagman M, Eduafo A, Edouard P, Mouradian J, Strom TB, Suthanthiran M. Molecular correlates of human renal allograft rejection. Transplant Proc. 1998 Aug; 30(5):2364-6.
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  166. Schachter AD, Vasconcellos L, Ophascharoensuk V, Zheng XX, Strehlau J, Strom TB. CTL effector mechanisms: diagnostic applications. Transplant Proc. 1998 Aug; 30(5):2344-6.
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  167. Li XC, Schachter AD, Zand MS, Li Y, Zheng XX, Harmon WE, Strom TB. Differential expression of T-cell growth factors in rejecting murine islet and human renal allografts: conspicuous absence of interleukin (IL)-9 despite expression of IL-2, IL-4, IL-7, and IL-15. Transplantation. 1998 Jul 27; 66(2):265-8.
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  168. Li XC, Roy-Chaudhury P, Hancock WW, Manfro R, Zand MS, Li Y, Zheng XX, Nickerson PW, Steiger J, Malek TR, Strom TB. IL-2 and IL-4 double knockout mice reject islet allografts: a role for novel T cell growth factors in allograft rejection. J Immunol. 1998 Jul 15; 161(2):890-6.
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  169. Kim YS, Maslinski W, Zheng XX, Stevens AC, Li XC, Tesch GH, Kelley VR, Strom TB. Targeting the IL-15 receptor with an antagonist IL-15 mutant/Fc gamma2a protein blocks delayed-type hypersensitivity. J Immunol. 1998 Jun 15; 160(12):5742-8.
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  170. Zheng XX, Schachter AD, Vasconcellos L, Strehlau J, Tian Y, Shapiro M, Harmon W, Strom TB. Increased CD40 ligand gene expression during human renal and murine islet allograft rejection. Transplantation. 1998 Jun 15; 65(11):1512-5.
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  171. Basadonna GP, Auersvald L, Khuong CQ, Zheng XX, Kashio N, Zekzer D, Minozzo M, Qian H, Visser L, Diepstra A, Lazarovits AI, Poppema S, Strom TB, Rothstein DM. Antibody-mediated targeting of CD45 isoforms: a novel immunotherapeutic strategy. Proc Natl Acad Sci U S A. 1998 Mar 31; 95(7):3821-6.
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  172. Suthanthiran M, Strom TB. Mechanisms and management of acute renal allograft rejection. Surg Clin North Am. 1998 Feb; 78(1):77-94.
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  173. Strom TB. Treating non-malignant disease states with IL-2 receptor-specific substances. 1997.
  174. Zhu G, Nicolson AG, Zheng XX, Strom TB, Sukhatme VP. Adenovirus-mediated beta-galactosidase gene delivery to the liver leads to protein deposition in kidney glomeruli. Kidney Int. 1997 Oct; 52(4):992-9.
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  175. Suthanthiran M, Strom TB. Immunoregulatory drugs: mechanistic basis for use in organ transplantation. Pediatr Nephrol. 1997 Oct; 11(5):651-7.
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  176. Tran HM, Nickerson PW, Restifo AC, Ivis-Woodward MA, Patel A, Allen RD, Strom TB, O'Connell PJ. Distinct mechanisms for the induction and maintenance of allograft tolerance with CTLA4-Fc treatment. J Immunol. 1997 Sep 1; 159(5):2232-9.
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  177. Muruve DA, Manfro RC, Strom TB, Libermann TA. Ex vivo adenovirus-mediated gene delivery leads to long-term expression in pancreatic islet transplants. Transplantation. 1997 Aug 15; 64(3):542-6.
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  178. Zheng XX, Sayegh MH, Zheng XG, Li Y, Linsley PS, Peach R, Borriello F, Strom TB, Sharpe AH, Turka LA. The role of donor and recipient B7-1 (CD80) in allograft rejection. J Immunol. 1997 Aug 1; 159(3):1169-73.
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  179. Roy-Chaudhury P, Nickerson PW, Manfro RC, Zheng XX, Steiger J, Li YS, Strom TB. CTLA4Ig attenuates accelerated rejection (presensitization) in the mouse islet allograft model. Transplantation. 1997 Jul 15; 64(1):172-5.
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  180. Bousvaros A, Stevens AC, Strom TB, Murphy J, Lamont JT. Interleukin-2 fusion protein (DAB389IL-2) selectively targets activated human peripheral blood and lamina propria lymphocytes. Dig Dis Sci. 1997 Jul; 42(7):1542-8.
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  181. Tivol EA, Boyd SD, McKeon S, Borriello F, Nickerson P, Strom TB, Sharpe AH. CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. J Immunol. 1997 Jun 1; 158(11):5091-4.
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  182. Muruve DA, Nicolson AG, Manfro RC, Strom TB, Sukhatme VP, Libermann TA. Adenovirus-mediated expression of Fas ligand induces hepatic apoptosis after Systemic administration and apoptosis of ex vivo-infected pancreatic islet allografts and isografts. Hum Gene Ther. 1997 May 20; 8(8):955-63.
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  183. Zheng XX, Steele AW, Hancock WW, Stevens AC, Nickerson PW, Roy-Chaudhury P, Tian Y, Strom TB. A noncytolytic IL-10/Fc fusion protein prevents diabetes, blocks autoimmunity, and promotes suppressor phenomena in NOD mice. J Immunol. 1997 May 1; 158(9):4507-13.
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  184. Stevens AC, Matthews J, Andres P, Baffis V, Zheng XX, Chae DW, Smith J, Strom TB, Maslinski W. Interleukin-15 signals T84 colonic epithelial cells in the absence of the interleukin-2 receptor beta-chain. Am J Physiol. 1997 May; 272(5 Pt 1):G1201-8.
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  185. Perez VL, Van Parijs L, Biuckians A, Zheng XX, Strom TB, Abbas AK. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity. 1997 Apr; 6(4):411-7.
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  186. Strom TB. Treatment of autoimmune diseases with IL-2 receptor-specific cytotoxin. 1997.
  187. Borriello F, Sethna MP, Boyd SD, Schweitzer AN, Tivol EA, Jacoby D, Strom TB, Simpson EM, Freeman GJ, Sharpe AH. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity. 1997 Mar; 6(3):303-13.
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  188. Nickerson P, Steiger J, Zheng XX, Steele AW, Steurer W, Roy-Chaudhury P, Strom TB. Manipulation of cytokine networks in transplantation: false hope or realistic opportunity for tolerance? Transplantation. 1997 Feb 27; 63(4):489-94.
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  189. Onodera K, Hancock WW, Graser E, Lehmann M, Sayegh MH, Strom TB, Volk HD, Kupiec-Weglinski JW. Type 2 helper T cell-type cytokines and the development of "infectious" tolerance in rat cardiac allograft recipients. J Immunol. 1997 Feb 15; 158(4):1572-81.
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  190. Manfro RC, Roy-Chaudhury P, Zheng XX, Steiger J, Nickerson PW, Li Y, Maslinski W, Strom TB. Interleukin-15 gene transcripts are present in rejecting islet allografts. Transplant Proc. 1997 Feb-Mar; 29(1-2):1077-8.
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  191. Wasowska B, Hancock WW, Onodera K, Korom S, Stadlbauer TH, Zheng XX, Strom TB, Kupiec-Weglinski JW. Rapamycin and cyclosporine A treatment: a novel regimen to prevent chronic allograft rejection in sensitized hosts. Transplant Proc. 1997 Feb-Mar; 29(1-2):333.
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  192. Roy-Chaudhury P, Manfro RC, Steiger J, Nickerson PW, Tian Y, Zheng XX, Li YS, Strom TB. IL-2 and IL-4 double knock-out mice reject islet allografts: a role for novel T-cell growth factors? Transplant Proc. 1997 Feb-Mar; 29(1-2):1083-4.
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  193. Strehlau J, Pavlakis M, Lipman M, Shapiro M, Vasconcellos L, Harmon W, Strom TB. Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):695-700.
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  194. Tran HM, Nickerson PW, Patel A, Strom TB, Allen RD, O'Connell PJ. Short term suppression of the xeno-immune response with mCTLA4-Fc treatment. Xenotransplantation. 1997; 4:222-7.
  195. Nickerson P, Zheng XX, Steiger J, Steele AW, Steurer W, Roy-Chaudhury P, Müller W, Strom TB. Prolonged islet allograft acceptance in the absence of expression of interleukin-4. Adv Nephrol Necker Hosp. 1997; 26:171-80.
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  196. Strom TB. Treatment of allograft rejection with IL-2 receptor-specific cytotoxins. 1996.
  197. Almawi WY, Saouda MS, Stevens AC, Lipman ML, Barth CM, Strom TB. Partial mediation of glucocorticoid antiproliferative effects by lipocortins. J Immunol. 1996 Dec 15; 157(12):5231-9.
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  198. Strom TB, Roy-Chaudhury P, Manfro R, Zheng XX, Nickerson PW, Wood K, Bushell A. The Th1/Th2 paradigm and the allograft response. Curr Opin Immunol. 1996 Oct; 8(5):688-93.
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  199. Chae DW, Nosaka Y, Strom TB, Maslinski W. Distribution of IL-15 receptor alpha-chains on human peripheral blood mononuclear cells and effect of immunosuppressive drugs on receptor expression. J Immunol. 1996 Oct 1; 157(7):2813-9.
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  200. Pavlakis M, Strehlau J, Lipman M, Shapiro M, Maslinski W, Strom TB. Intragraft IL-15 transcripts are increased in human renal allograft rejection. Transplantation. 1996 Aug 27; 62(4):543-5.
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  201. Suthanthiran M, Morris RE, Strom TB. Immunosuppressants: cellular and molecular mechanisms of action. Am J Kidney Dis. 1996 Aug; 28(2):159-72.
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  202. Pavlakis M, Strehlau J, Lipman M, Strom TB. Use of intragraft gene expression in the diagnosis of kidney allograft rejection. Transplant Proc. 1996 Aug; 28(4):2019-21.
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  203. Wieder KJ, Chatis P, Boltax J, Wieder I, Nuovo G, Strom TB. Human immunodeficiency virus type 1 entry into murine cell lines and lymphocytes from transgenic mice expressing a glycoprotein 120-binding mutant mouse CD4. AIDS Res Hum Retroviruses. 1996 Jul 1; 12(10):867-76.
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  204. Strehlau J, Pavlakis M, Lipman M, Maslinski W, Shapiro M, Strom TB. The intragraft gene activation of markers reflecting T-cell-activation and -cytotoxicity analyzed by quantitative RT-PCR in renal transplantation. Clin Nephrol. 1996 Jul; 46(1):30-3.
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  205. Strom TB, Suthanthiran M. Therapeutic approach to organ transplantation. Nephrol Dial Transplant. 1996 Jun; 11(6):1176-81.
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  206. Flores-Villanueva PO, Zheng XX, Strom TB, Stadecker MJ. Recombinant IL-10 and IL-10/Fc treatment down-regulate egg antigen-specific delayed hypersensitivity reactions and egg granuloma formation in schistosomiasis. J Immunol. 1996 May 1; 156(9):3315-20.
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  207. Strom TB. Treatment of autoimmune diseases with IL-2 receptor-specific cytotoxins. 1996.
  208. Dunussi-Joannopoulos K, Weinstein HJ, Nickerson PW, Strom TB, Burakoff SJ, Croop JM, Arceci RJ. Irradiated B7-1 transduced primary acute myelogenous leukemia (AML) cells can be used as therapeutic vaccines in murine AML. Blood. 1996 Apr 1; 87(7):2938-46.
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  209. Nickerson P, Zheng XX, Steiger J, Steele AW, Steurer W, Roy-Chaudhury P, Müller W, Strom TB. Prolonged islet allograft acceptance in the absence of interleukin 4 expression. Transpl Immunol. 1996 Mar; 4(1):81-5.
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  210. Barth C, Pavlakis M, Lavery P, Strom TB, Loertscher R. Restricted TCR V beta repertoire in the human mixed lymphocyte reaction is determined by the TCR on the responder cell and not by the stimulating antigen on the stimulator cell. Transplantation. 1996 Jan 15; 61(1):133-9.
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  211. Wasowska B, Wieder KJ, Hancock WW, Zheng XX, Berse B, Binder J, Strom TB, Kupiec-Weglinski JW. Cytokine and alloantibody networks in long term cardiac allografts in rat recipients treated with rapamycin. J Immunol. 1996 Jan 1; 156(1):395-404.
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  212. Austen KF, Burakoff SJ, Rosen FS, Strom TB. Therapeutic Immunology. 1996.
  213. Pavlakis M, Lipman M, Strom TB. Intragraft expression of T-cell activation genes in human renal allograft rejection. Kidney Int Suppl. 1996 Jan; 53:S7-12.
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  214. Tilney NL, Strom TB, Paul LC. Transplantation Biology: Cellular and Molecular Aspects. 1996.
  215. Shapiro ME, Abrams JM, Brown RS, Steinman TI, Strom TB. Successful pancreas-renal transplantation without anti-T-cell antibody induction. Transplant Proc. 1995 Dec; 27(6):3087-8.
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  216. Strom TB, Steele AW, Nichols J. Genetically engineered proteins for immunoregulation. Transplant Proc. 1995 Oct; 27(5 Suppl 1):18-20.
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  217. Steurer W, Nickerson PW, Steele AW, Steiger J, Zheng XX, Strom TB. Ex vivo coating of islet cell allografts with murine CTLA4/Fc promotes graft tolerance. J Immunol. 1995 Aug 1; 155(3):1165-74.
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  218. Pavlakis M, Lipman ML, Strom TB. Intragraft T cell receptor transcript expression in human renal allografts. J Am Soc Nephrol. 1995 Aug; 6(2):281-5.
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  219. Suthanthiran M, Strom TB. Immunobiology and immunopharmacology of organ allograft rejection. J Clin Immunol. 1995 Jul; 15(4):161-71.
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  220. Steiger J, Nickerson PW, Steurer W, Moscovitch-Lopatin M, Strom TB. IL-2 knockout recipient mice reject islet cell allografts. J Immunol. 1995 Jul 1; 155(1):489-98.
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  221. Zheng XX, Steele AW, Nickerson PW, Steurer W, Steiger J, Strom TB. Administration of noncytolytic IL-10/Fc in murine models of lipopolysaccharide-induced septic shock and allogeneic islet transplantation. J Immunol. 1995 May 15; 154(10):5590-600.
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  222. Meisels IS, Strom TB, Roy-Chaudhury P, Abrams J, Shapiro ME. Renal allograft rejection in a patient with the Wiskott-Aldrich syndrome. Transplantation. 1995 Apr 27; 59(8):1214-5.
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  223. Bennett WM, Carpenter CB, Shapiro ME, Strom TB, Hefty D, Tillman M, Abrams J, Ryan D, Kelley VR. Delayed omega-3 fatty acid supplements in renal transplantation. A double-blind, placebo-controlled study. Transplantation. 1995 Feb 15; 59(3):352-6.
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  224. Wasowska B, Wieder KJ, Hancock WW, Berse B, Binder J, Strom TB, Kupiec-Weglinski JW. Cytokine and alloantibody networks in long-term cardiac allografts in rapamycin-treated sensitized rat recipients. Transplant Proc. 1995 Feb; 27(1):423-6.
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  225. Stevens C, Lipman M, Fabry S, Moscovitch-Lopatin M, Almawi W, Keresztes S, Peppercorn MA, Strom TB. 5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells. J Pharmacol Exp Ther. 1995 Jan; 272(1):399-406.
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  226. Stevens AC, Lipman ML, Spivack JE, Roddey G, Bitton AM, Peppercorn MA, Strom TB. Enhanced intramucosal cytotoxic lymphocyte gene expression in ulcerative colitis. Inflammatory Bowel Dis. 1995; 101-7.
  227. Stevens AC, Lipman ML, Spivack JE, Roddey G, Bitton AM, Peppercorn MA, Strom TB. Enhanced intramucosal cytotoxic lymphocyte gene expression in ulcerative colitis. Inflamm Bowel Dis. 1995; 1(2):101-7.
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  228. Kelley VR, Strom TB. A paradigm 1994: the allograft response. Blood Purif. 1995; 13(3-4):199-205.
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  229. Nickerson P, Steurer W, Steiger J, Zheng X, Steele AW, Strom TB. Cytokines and the Th1/Th2 paradigm in transplantation. Curr Opin Immunol. 1994 Oct; 6(5):757-64.
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  230. Suthanthiran M, Strom TB. Renal transplantation. N Engl J Med. 1994 Aug 11; 331(6):365-76.
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  231. Strom TB. Treatment of allograft rejection with IL-2 receptor-specific cytotoxins. 1994.
  232. Zheng XX, Strom TB, Steele AW. Quantitative comparison of rapamycin and cyclosporine effects on cytokine gene expression studied by reverse transcriptase-competitive polymerase chain reaction. Transplantation. 1994 Jul 15; 58(1):87-92.
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  233. Zanker B, Marx S, Strom TB, Köhler H. The immunosuppressive effects of verapamil upon mitogen activated and allo-antigen inducible human cytotoxic T-lymphocytes. Int J Immunopharmacol. 1994 Jul; 16(7):507-17.
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  234. Lipman ML, Stevens AC, Strom TB. Heightened intragraft CTL gene expression in acutely rejecting renal allografts. J Immunol. 1994 May 15; 152(10):5120-7.
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  235. Barber GN, Thompson S, Lee TG, Strom T, Jagus R, Darveau A, Katze MG. The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4278-82.
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  236. Hricik DE, Almawi WY, Strom TB. Trends in the use of glucocorticoids in renal transplantation. Transplantation. 1994 Apr 15; 57(7):979-89.
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  237. Yokoyama H, Zheng X, Strom TB, Kelley VR. B7(+)-transfectant tubular epithelial cells induce T cell anergy, ignorance or proliferation. Kidney Int. 1994 Apr; 45(4):1105-12.
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  238. Nickerson PW, Steurer W, Steiger J, Strom TB. In pursuit of the "holy grail": allograft tolerance. Kidney Int Suppl. 1994 Jan; 44:S40-9.
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  239. Strom TB, Kelley VR, Murphy JR, Nichols J, Woodworth TG. Interleukin-2 receptor-directed therapies: antibody- or cytokine-based targeting molecules. Adv Nephrol Necker Hosp. 1994; 23:347-56.
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  240. Wieder KJ, Hancock WW, Schmidbauer G, Corpier CL, Wieder I, Kobzik L, Strom TB, Kupiec-Weglinski JW. Rapamycin treatment depresses intragraft expression of KC/MIP-2, granzyme B, and IFN-gamma in rat recipients of cardiac allografts. J Immunol. 1993 Jul 15; 151(2):1158-66.
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  241. Maslinski W, Remillard B, Tsudo M, Strom TB. Interleukin-2 receptor signal transduction: translocation of active serine-threonine kinase Raf-1 from IL-2 receptor into cytosol depends on IL-2-induced tyrosine kinase activation. Transplant Proc. 1993 Feb; 25(1 Pt 1):109-10.
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  242. Nickerson P, Pacheco-Silva A, O'Connell PJ, Steurer W, Kelley VR, Strom TB. Analysis of cytokine transcripts in pancreatic islet cell allografts during rejection and tolerance induction. Transplant Proc. 1993 Feb; 25(1 Pt 2):984-5.
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  243. Strom TB. Summation of the biologic aspects of the congress. Transplant Proc. 1993 Feb; 25(1 Pt 2):1284-6.
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  244. O'Connell PJ, Pacheco-Silva A, Nickerson PW, Muggia RA, Bastos M, Kelley VR, Strom TB. Unmodified pancreatic islet allograft rejection results in the preferential expression of certain T cell activation transcripts. J Immunol. 1993 Feb 1; 150(3):1093-104.
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  245. Ascher NL, Hansen JA, Strom TB. Year Book of Transplantation. 1993.
  246. Strom TB, Kelley VR, Murphy JR, Nichols J, Woodworth TG. Interleukin-2 receptor-directed therapies: antibody-or cytokine-based targeting molecules. Annu Rev Med. 1993; 44:343-53.
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  247. Pritchard AE, Strom T, Lipton HL. Nucleotide sequence identifies Vilyuisk virus as a divergent Theiler's virus. Virology. 1992 Nov; 191(1):469-72.
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  248. Strom TB, Kelley VE. Induction of tolerance to a foreign antigen IL-2 receptor-binding substances. 1992.
  249. Strom TB. Molecular immunology and immunopharmacology of allograft rejection. Kidney Int Suppl. 1992 Oct; 38:S182-7.
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  250. Strom TB, Kelley VR, Woodworth TG, Murphy JR. Interleukin-2 receptor-directed immunosuppressive therapies: antibody- or cytokine-based targeting molecules. Immunol Rev. 1992 Oct; 129:131-63.
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  251. Díaz-Gallo C, Moscovitch-Lopatin M, Strom TB, Kelley VR. An anergic, islet-infiltrating T-cell clone that suppresses murine diabetes secretes a factor that blocks interleukin 2/interleukin 4-dependent proliferation. Proc Natl Acad Sci U S A. 1992 Sep 15; 89(18):8656-60.
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  252. Maslinski W, Remillard B, Tsudo M, Strom TB. Interleukin-2 (IL-2) induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2 receptor into the cytosol. J Biol Chem. 1992 Aug 5; 267(22):15281-4.
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  253. Stevens C, Walz G, Singaram C, Lipman ML, Zanker B, Muggia A, Antonioli D, Peppercorn MA, Strom TB. Tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 expression in inflammatory bowel disease. Dig Dis Sci. 1992 Jun; 37(6):818-26.
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  254. Maslinski W, Murphy JR, Strom TB. Intoxication of high affinity IL-2 receptor positive thymocytes blocks early stages of T cell maturation. Int Immunol. 1992 Apr; 4(4):509-17.
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  255. Lakkis F, Landgraf B, Wen Z, Strom TB, Murphy JR. Phe496 and Leu497 are essential for receptor binding and cytotoxic action of the murine interleukin-4 receptor targeted fusion toxin DAB389-mIL-4. Protein Eng. 1992 Apr; 5(3):241-8.
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  256. Pacheco-Silva A, Bastos MG, Muggia RA, Pankewycz O, Nichols J, Murphy JR, Strom TB, Rubin-Kelley VE. Interleukin 2 receptor targeted fusion toxin (DAB486-IL-2) treatment blocks diabetogenic autoimmunity in non-obese diabetic mice. Eur J Immunol. 1992 Mar; 22(3):697-702.
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  257. Papp I, Wieder KJ, Sablinski T, O'Connell PJ, Milford EL, Strom TB, Kupiec-Weglinski JW. Evidence for functional heterogeneity of rat CD4+ T cells in vivo. Differential expression of IL-2 and IL-4 mRNA in recipients of cardiac allografts. J Immunol. 1992 Mar 1; 148(5):1308-14.
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  258. Shapiro ME, Kirkman RL, Kelley VR, Bacha P, Nichols JC, Strom TB. In vivo studies with chimeric toxins. Interleukin-2 fusion toxins as immunosuppressive agents. Targeted Diagn Ther. 1992; 7:383-93.
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  259. Murphy JR, Lakkis FG, vanderSpek JC, Anderson P, Strom TB. Protein engineering of diphtheria toxin. Development of receptor-specific cytotoxic agents for the treatment of human disease. Targeted Diagn Ther. 1992; 7:365-82.
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  260. Barel D, Brennan DC, Jevnikar AM, Bastos M, Strom TB, Kelley VR. Enhanced tumor necrosis factor in anti-CD3 antibody stimulated diabetic NOD mice: modulation by PGE1 and dietary lipid. Autoimmunity. 1992; 13(2):141-9.
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  261. Coe FL, Favus MU, Henderson L, Kashgarian M, Luke RG, Myers B, Strom TB. Year Book of Nephrology. 1992.
  262. Lipman ML, Stevens AC, Bleackley RC, Helderman JH, McCune TR, Harmon WE, Shapiro ME, Rosen S, Strom TB. The strong correlation of cytotoxic T lymphocyte-specific serine protease gene transcripts with renal allograft rejection. Transplantation. 1992 Jan; 53(1):73-9.
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  263. Ascher NL, Hansen JA, Strom TB. Year Book of Transplantation. 1992.
  264. Waters CA, Snider CE, Itoh K, Poisson L, Strom TB, Murphy JR, Nichols JC. DAB486IL-2 (IL-2 toxin) selectively inactivates high-affinity IL-2 receptor-bearing human peripheral blood mononuclear cells. Ann N Y Acad Sci. 1991 Dec 30; 636:403-5.
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  265. Strom TB, Anderson PL, Rubin-Kelley VE, Williams DP, Kiyokawa T, Murphy JR. Immunotoxins and cytokine toxin fusion proteins. Ann N Y Acad Sci. 1991 Dec 30; 636:233-50.
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  266. Kiyokawa T, Williams DP, Snider CE, Waters CA, Nichols JC, Strom TB, Murphy JR. Protein engineering of DAB-IL-2 fusion toxins to increase biologic potency. Ann N Y Acad Sci. 1991 Dec 30; 636:331-9.
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  267. Lakkis F, Steele A, Pacheco-Silva A, Rubin-Kelley V, Strom TB, Murphy JR. Interleukin 4 receptor targeted cytotoxicity: genetic construction and in vivo immunosuppressive activity of a diphtheria toxin-related murine interleukin 4 fusion protein. Eur J Immunol. 1991 Sep; 21(9):2253-8.
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  268. Remillard B, Petrillo R, Maslinski W, Tsudo M, Strom TB, Cantley L, Varticovski L. Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase. J Biol Chem. 1991 Aug 5; 266(22):14167-70.
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  269. Kunzendorf U, Walz G, Brockmoeller J, Neumayer HH, Jochimsen F, Roots I, Offermann G, Strom TB. Effects of diltiazem upon metabolism and immunosuppressive action of cyclosporine in kidney graft recipients. Transplantation. 1991 Aug; 52(2):280-4.
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  270. Tilney NL, Chang A, Milford EL, Whitley WD, Lazarus JM, Ramos EL, Strom TB, Carpenter CB, Kirkman RL. Ten-year experience with cyclosporine as primary immunosuppression in recipients of renal allografts. Ann Surg. 1991 Jul; 214(1):42-9.
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  271. Almawi WY, Hadro ET, Strom TB. Evidence that glucocorticosteroid-mediated immunosuppressive effects do not involve altering second messenger function. Transplantation. 1991 Jul; 52(1):133-40.
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  272. Finberg RW, Wahl SM, Allen JB, Soman G, Strom TB, Murphy JR, Nichols JC. Selective elimination of HIV-1-infected cells with an interleukin-2 receptor-specific cytotoxin. Science. 1991 Jun 21; 252(5013):1703-5.
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  273. Moscovitch-Lopatin M, Petrillo RJ, Pankewycz OG, Hadro E, Bleackley CR, Strom TB, Wieder KJ. Interleukin 2 counteracts the inhibition of cytotoxic T lymphocytes by cholera toxin in vitro and in vivo. Eur J Immunol. 1991 Jun; 21(6):1439-44.
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  274. Almawi WY, Lipman ML, Stevens AC, Zanker B, Hadro ET, Strom TB. Abrogation of glucocorticoid-mediated inhibition of T cell proliferation by the synergistic action of IL-1, IL-6, and IFN-gamma. J Immunol. 1991 May 15; 146(10):3523-7.
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  275. Walz G, Stevens C, Zanker B, Melton LB, Clark SC, Suthanthiran M, Strom TB. The role of interleukin-6 in mitogenic T-cell activation: detection of interleukin-2 heteronuclear RNA by polymerase chain reaction. Cell Immunol. 1991 May; 134(2):511-9.
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  276. Kim D, Porter DH, Siegel JB, Shapiro ME, Strom TB, Glotzer DJ. Use of a reperfusion catheter after angioplasty dissection for salvage of ischemic renal allograft: case report. Cardiovasc Intervent Radiol. 1991 May-Jun; 14(3):179-82.
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  277. Strom TB. Lysing or blocking unwanted cels with IL-2 receptor-specific binding substance. 1991.
  278. Pankewycz O, Strom TB, Rubin-Kelley VE. Islet-infiltrating T cell clones from non-obese diabetic mice that promote or prevent accelerated onset diabetes. Eur J Immunol. 1991 Apr; 21(4):873-9.
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  279. Kiyokawa T, Williams DP, Snider CE, Strom TB, Murphy JR. Protein engineering of diphtheria-toxin-related interleukin-2 fusion toxins to increase cytotoxic potency for high-affinity IL-2-receptor-bearing target cells. Protein Eng. 1991 Apr; 4(4):463-8.
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  280. Köhler H, Zanker B, Strom TB. [The immunobiology of transplant rejection and its pharmacological modification]. Dtsch Med Wochenschr. 1991 Feb 15; 116(7):264-9.
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  281. Barth C, O'Connell P, Zanker B, Strom TB. Interleukin-7 (IL-7) and its effect on the expression of the intercellular adhesion molecule (ICAM-1) in T cells. Transplant Proc. 1991 Feb; 23(1 Pt 1):824-5.
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  282. Kirkman RL, Shapiro ME, Carpenter CB, McKay DB, Milford EL, Ramos EL, Tilney NL, Waldmann TA, Zimmerman CE, Strom TB. A randomized prospective trial of anti-Tac monoclonal antibody in human renal transplantation. Transplant Proc. 1991 Feb; 23(1 Pt 2):1066-7.
    View in: PubMed
  283. O'Connell PJ, Pacheco-Silva A, Bastos M, Xu HW, Pankewycz O, Rubin-Kelley VE, Strom TB. Sequential analysis by polymerase chain reaction of mononuclear leukocyte activation-associated transcription in pancreatic islet cell allograft rejection. Transplant Proc. 1991 Feb; 23(1 Pt 1):811-2.
    View in: PubMed
  284. Grailer AP, Nichols JC, Strom TB, Sollinger HW, Burlingham WJ. Inhibition of human antigen-specific memory B cell response in vitro by a diphtheria toxin-related interleukin 2 fusion protein. Cell Immunol. 1991 Feb; 132(2):481-93.
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  285. Snydman DR, Werner BG, Tilney NL, Kirkman RL, Milford EL, Cho SI, Bush HL, Levey AS, Strom TB, Carpenter CB, et al. Final analysis of primary cytomegalovirus disease prevention in renal transplant recipients with a cytomegalovirus-immune globulin: comparison of the randomized and open-label trials. Transplant Proc. 1991 Feb; 23(1 Pt 2):1357-60.
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  286. Sehajpal PK, Li B, Zanker B, Murthi VK, Subramaniam A, Sharma VK, Estin D, Skilnik EY, Wieder KJ, Walz G, Fotino M, Stenzel KH, Strom TB, Suthanthiran M. The molecular basis for the synergism between CD3 alpha beta T-cell receptor and the CD2 antigen-derived signals in promoting T-cell proliferation . Transplantation. 1991; 51:468-74.
  287. Kirkman RL, Shapiro ME, Carpenter CB, McKay DB, Milford EL, Ramos EL, Tilney NL, Waldmann TA, Zimmerman CE, Strom TB. A randomized prospective trial of anti-Tac monoclonal antibody in human renal transplantation. Transplantation. 1991 Jan; 51(1):107-13.
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  288. Bastos MG, Pankewycz O, Rubin-Kelley VE, Murphy JR, Strom TB. Concomitant administration of hapten and IL-2-toxin (DAB486-IL-2) results in specific deletion of antigen-activated T cell clones. J Immunol. 1990 Dec 1; 145(11):3535-9.
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  289. Williams DP, Wen Z, Watson RS, Boyd J, Strom TB, Murphy JR. Cellular processing of the interleukin-2 fusion toxin DAB486-IL-2 and efficient delivery of diphtheria fragment A to the cytosol of target cells requires Arg194. J Biol Chem. 1990 Nov 25; 265(33):20673-7.
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  290. Strom TB, Anderson PL, Rubin-Kelley VE, Williams DP, Kiyokawa T, Murphy JR. Immunotoxins and cytokine toxin fusion proteins. Semin Immunol. 1990 Nov; 2(6):467-79.
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  291. Williams DP, Snider CE, Strom TB, Murphy JR. Structure/function analysis of interleukin-2-toxin (DAB486-IL-2). Fragment B sequences required for the delivery of fragment A to the cytosol of target cells. J Biol Chem. 1990 Jul 15; 265(20):11885-9.
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  292. Wieder KJ, Walz G, Zanker B, Sehajpal P, Sharma VK, Skolnik E, Strom TB, Suthanthiran M. Physiologic signaling in normal human T-cells: mRNA phenotyping by northern blot analysis and reverse transcription-polymerase chain reaction. Cell Immunol. 1990 Jun; 128(1):41-51.
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  293. Walz G, Zanker B, Barth C, Wieder KJ, Clark SC, Strom TB. Transcriptional modulation of human IL-6 gene expression by verapamil. J Immunol. 1990 Jun 1; 144(11):4242-8.
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  294. Mackie JD, Pankewycz OG, Bastos MG, Kelley VE, Strom TB. Dose-related mechanisms of immunosuppression mediated by murine anti-CD3 monoclonal antibody in pancreatic islet cell transplantation and delayed-type hypersensitivity. Transplantation. 1990 Jun; 49(6):1150-4.
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  295. Waters CA, Schimke PA, Snider CE, Itoh K, Smith KA, Nichols JC, Strom TB, Murphy JR. Interleukin 2 receptor-targeted cytotoxicity. Receptor binding requirements for entry of a diphtheria toxin-related interleukin 2 fusion protein into cells. Eur J Immunol. 1990 Apr; 20(4):785-91.
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  296. Pankewycz OG, Yui M, Kelley VE, Strom TB. The cascading, interrelated roles of interleukin-1, interleukin-2, and interleukin-6 in murine anti-CD3-driven T cell proliferation. Clin Immunol Immunopathol. 1990 Apr; 55(1):67-85.
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  297. Lugasi H, Hajos S, Murphy JR, Strom TB, Nichols J, Peñarroja C, Naor D. Murine spontaneous T-cell leukemia constitutively expressing IL-2 receptor--a model for human T-cell malignancies expressing IL-2 receptor. Int J Cancer. 1990 Jan 15; 45(1):163-7.
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  298. Zanker B, Walz G, Wieder KJ, Strom TB. Evidence that glucocorticosteroids block expression of the human interleukin-6 gene by accessory cells. Transplantation. 1990 Jan; 49(1):183-5.
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  299. Walz G, Zanker B, Murphy JR, Strom TB. A kinetic analysis of the effects of interleukin-2 diphtheria toxin fusion protein upon activated T cells. Transplantation. 1990 Jan; 49(1):198-201.
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  300. Walz G, Zanker B, Melton LB, Suthanthiran M, Strom TB. Possible association of the immunosuppressive and B cell lymphoma-promoting properties of cyclosporine. Transplantation. 1990 Jan; 49(1):191-4.
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  301. Walz G, Zanker B, Brand K, Waters C, Genbauffe F, Zeldis JB, Murphy JR, Strom TB. Sequential effects of interleukin 2-diphtheria toxin fusion protein on T-cell activation. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9485-8.
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  302. Carpenter CB, Kirkman RL, Shapiro ME, Milford EL, Tiney NL, Waldmann TA, Zimmerman CE, Ramos EL, Strom TB. Prophylactic use of monoclonal anti-IL-2 receptor antibody in cadaveric renal transplantation. Am J Kidney Dis. 1989 Nov; 14(5 Suppl 2):54-7.
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  303. Heagy W, Strom TB, Kelley VE, Collela J, Crumpacker C, Williams JM, Shapiro HM, Laubenstein L, Finberg R. Recombinant human gamma interferon enhances in vitro activation of lymphocytes isolated from patients with acquired immunodeficiency syndrome. Infect Immun. 1989 Nov; 57(11):3619-28.
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  304. Shapiro ME, Reed MH, Strom TB, Carpenter CB, Milford EL, Kirkman RL. The role of a primate model of renal transplantation in the development of new monoclonal antibodies. Am J Kidney Dis. 1989 Nov; 14(5 Suppl 2):58-60.
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  305. Ramos EL, Milford EL, Kirkman RL, Tilney NL, Strom TB, Shapiro ME, Waldmann TA, Wood IG, Rollins MR, Carpenter CB. Differential IL-2 receptor expression in renal allograft recipients treated with an anti-IL-2-receptor antibody. Transplantation. 1989 Sep; 48(3):415-20.
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  306. Loertscher R, Strom TB. Differential regulation of activation-associated receptor expression on CD4- and CD8-positive T lymphocytes by allosensitized suppressor T cells. Transplantation. 1989 Sep; 48(3):473-8.
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  307. Kiyokawa T, Shirono K, Hattori T, Nishimura H, Yamaguchi K, Nichols JC, Strom TB, Murphy JR, Takatsuki K. Cytotoxicity of interleukin 2-toxin toward lymphocytes from patients with adult T-cell leukemia. Cancer Res. 1989 Jul 15; 49(14):4042-6.
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  308. Kelley VE, Kirkman RL, Bastos M, Barrett LV, Strom TB. Enhancement of immunosuppression by substitution of fish oil for olive oil as a vehicle for cyclosporine. Transplantation. 1989 Jul; 48(1):98-102.
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  309. Diamantstein T, Kupiec-Weglinski JW, Strom TB, Tilney NL. Current stage of interleukin 2 receptor targeted therapy. Exp Clin Endocrinol. 1989 May; 93(2-3):114-24.
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  310. Strom TB, Kelley VE. Toward more selective therapies to block undesired immune responses. Kidney Int. 1989 Apr; 35(4):1026-33.
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  311. Pankewycz O, Strom TB, Kelley VE. Therapeutic strategies using monoclonal antibodies in autoimmune disease. Curr Opin Immunol. 1989 Apr; 1(4):757-63.
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  312. Kirkman RL, Bacha P, Barrett LV, Forte S, Murphy JR, Strom TB. Prolongation of cardiac allograft survival in murine recipients treated with a diphtheria toxin-related interleukin-2 fusion protein. Transplantation. 1989 Feb; 47(2):327-30.
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  313. Melton LB, Lakkis F, Moscovitch-Lopatin M, Smith BR, Williams JM, Rosoff PM, Strom TB. Antibody valence and induced signal transduction: the role of antibody valence in anti-CD3-induced signal transduction in isolated normal T cells. Clin Immunol Immunopathol. 1989 Feb; 50(2):171-83.
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  314. Kirkman RL, Shapiro ME, Carpenter CB, Milford EL, Ramos EL, Tilney NL, Waldmann TA, Zimmerman CE, Strom TB. Early experience with anti-Tac in clinical renal transplantation. Transplant Proc. 1989 Feb; 21(1 Pt 2):1766-8.
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  315. Walz G, Zanker B, Wieder K, Hadro E, Moscovitch-Lopatin M, Smith BR, Strom TB. Similar effects of cyclosporine and verapamil on lymphokine, interleukin 2 receptor, and proto-oncogene expression. Transplantation. 1989 Feb; 47(2):331-4.
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  316. Barrett LV, Murphy JR, Strom TB, Kirkman RL. Treatment with a diphtheria toxin-related interleukin 2 fusion protein prolongs cardiac allograft survival in mice. Transplant Proc. 1989 Feb; 21(1 Pt 1):1130-1.
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  317. Pankewycz O, Mackie J, Hassarjian R, Murphy JR, Strom TB, Kelley VE. Interleukin-2-diphtheria toxin fusion protein prolongs murine islet cell engraftment. Transplantation. 1989 Feb; 47(2):318-22.
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  318. Mackie JD, Pankewycz OG, Hassarjian R, Murphy JR, Kelley VE, Strom TB. Immunotherapy using interleukin-2 diphtheria toxin chimer prolongs murine allografts. Transplant Proc. 1989 Feb; 21(1 Pt 3):2718-9.
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  319. Zanker B, Walz G, Wieder KJ, Moscovitch-Lopatin M, Smith BR, Strom TB. Verapamil selectively inhibits expression of interleukin-2 messenger RNA in mitogen activated mononuclear blood cells. Transplant Proc. 1989 Feb; 21(1 Pt 1):85-7.
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  320. Reed MH, Shapiro ME, Strom TB, Carpenter CB, Letvin NL, Reimann K, Weinberg DS, Waldmann TA, Kirkman RL. Anti-TAC MOAB prolongs renal allografts in cynomolgus monkeys. Transplant Proc. 1989 Feb; 21(1 Pt 1):1028-30.
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  321. Kelley VE, Mackie J, Strom TB. Cyclosporin A plus fish oil: accentuate the positive, eliminate the negative. Transplant Proc. 1989 Feb; 21(1 Pt 1):848-9.
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  322. Reed MH, Shapiro ME, Strom TB, Milford EL, Carpenter CB, Weinberg DS, Reimann KA, Letvin NL, Waldmann TA, Kirkman RL. Prolongation of primate renal allograft survival by anti-Tac, an anti-human IL-2 receptor monoclonal antibody. Transplantation. 1989 Jan; 47(1):55-9.
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  323. Strom TB, Colvin RB. [Fever and changes in renal function after kidney and pancreas transplant in a 22-year-old diabetic woman]. Medicina (Firenze). 1989 Jan-Mar; 9(1):83-92.
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  324. Ramos EL, Leggat JE, Milford EL, Kirkman RL, Tilney NL, Strom TB, Shapiro ME, Waldmann TA, Carpenter CB. In vivo anti-interleukin-2 receptor (anti-Tac) therapy is immunosuppressive, but not tolerogenic. Trans Assoc Am Physicians. 1989; 102:231-9.
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  325. Shapiro ME, Kirkman RL, Carpenter CB, Milford EL, Tilney NL, Waldmann TA, Zimmerman CE, Ramos EL, Strom TB. Initial trials of the anti-human IL-2 receptor monoclonal antibody anti-Tac in clinical renal transplantation. Transplantation. 1989; 47:55-9.
  326. Zanker B, Walz G, Strom TB. Expression von Aktivierungsgenen in T-Zellen und deren inhibition durch cyclosporin A und Veraparmil. Nieren und Hochdruck-krankheiten. 1989; 7:S269-71.
  327. Snydman DR, Werner BG, Tilney NL, Kirkman RL, Milford EL, Cho SI, Bush HL, Levey AS, Strom TB, Carpenter CB, et al. A further analysis of primary cytomegalovirus disease prevention in renal transplant recipients with a cytomegalovirus immune globulin: interim comparison of a randomized and an open-label trial. Transplant Proc. 1988 Dec; 20(6 Suppl 8):24-30.
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  328. Leichtman AB, Strom TB. Therapeutic approach to renal transplantation: triple therapy and beyond. Transplant Proc. 1988 Dec; 20(6 Suppl 8):1-6.
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  329. Tilney NL, Padberg WM, Lord RH, Araneda D, Strom TB, Kupiec-Weglinski JW. Synergy between subtherapeutic doses of cyclosporine and immunobiological manipulations in rat heart graft recipients. Transplantation. 1988 Aug; 46(2 Suppl):122S-128S.
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  330. Johns MA, Sipe JD, Melton LB, Strom TB, McCabe WR. Endotoxin-associated protein: interleukin-1-like activity on serum amyloid A synthesis and T-lymphocyte activation. Infect Immun. 1988 Jun; 56(6):1593-601.
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  331. Tilney NL, Strom TB, Kupiec-Weglinski JW. Pharmacologic and immunologic agonists and antagonists of cyclosporine. Transplant Proc. 1988 Jun; 20(3 Suppl 3):13-22.
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  332. Kelley VE, Bacha P, Pankewycz O, Nichols JC, Murphy JR, Strom TB. Interleukin 2-diphtheria toxin fusion protein can abolish cell-mediated immunity in vivo. Proc Natl Acad Sci U S A. 1988 Jun; 85(11):3980-4.
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  333. Pankewycz OG, Hassarjian R, Chang C, Strom TB, Kelley VE. Anti-interleukin-2 receptor monoclonal antibody therapy induces anti-idiotypic antibodies in mice that block both in vitro and in vivo activity. J Autoimmun. 1988 Apr; 1(2):119-30.
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  334. Strom TB. The cellular and molecular basis of allograft rejection: what do we know? Transplant Proc. 1988 Apr; 20(2):143-6.
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  335. Kupiec-Weglinski JW, Hahn HJ, Kirkman RL, Volk HD, Mouzaki A, DiStefano R, Tellides G, Dallman M, Morris PJ, Strom TB, et al. Cyclosporine potentiates the immunosuppressive effects of anti-interleukin 2 receptor monoclonal antibody therapy. Transplant Proc. 1988 Apr; 20(2 Suppl 2):207-16.
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  336. Murphy JR, Kelley VE, Strom TB. Interleukin 2 toxin: a step toward selective immunomodulation. Am J Kidney Dis. 1988 Feb; 11(2):159-62.
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  337. Bacha P, Williams DP, Waters C, Williams JM, Murphy JR, Strom TB. Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein. J Exp Med. 1988 Feb 1; 167(2):612-22.
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  338. Kelley VE, Gaulton GN, Hattori M, Ikegami H, Eisenbarth G, Strom TB. Anti-interleukin 2 receptor antibody suppresses murine diabetic insulitis and lupus nephritis. J Immunol. 1988 Jan 1; 140(1):59-61.
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  339. Loertscher R, Leichtman AB, Williams JM, Strom TB. Blocking of T cell activation at the G1A/G1B interface of the cell cycle and prevention of expression of interleukin 2 receptors by alloactivated suppressor T lymphocytes. Transplantation. 1988 Jan; 45(1):194-201.
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  340. Waters C, Schmike P, Sanderson R, Strom TB, Murphy JR. Receptor binding requirements for IL-2 toxin mediated cytotoxicity. J Cell Biochem. 1988; 12E(Suppl):U312.
  341. Reed MH, Shapiro ME, Strom TB, Milford EL, Carpenter CB, Letvin NL, Waldmann TA, Kirkman RL. Prolongation of primate renal allografts with anti-Tac monoclonal antibody. Curr Surg. 1988 Jan-Feb; 45(1):28-30.
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  342. Lipsky PF, Strom TB. Immunology and Allergy Clinics of North America. 1988.
  343. Murphy JR, Williams DP, Bacha P, Bishai W, Waters C, Strom TB. Cell receptor specific targeted toxins: genetic construction and characterization of an interleukin 2 diphtheria toxin-related fusion protein. J Recept Res. 1988; 8(1-4):467-80.
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  344. Diamantstein T, Mouzaki A, Osawa H, Volk HD, Hahn HJ, Kirkman RL, Strom TB, Tilney NL, Kupiec-Weglinski JW. Inhibition of allograft rejection and organ-specific autoimmune disease by anti-interleukin-2 receptor (IL-2R)-targeted immunotherapy. The action of anti-IL-2R monoclonal antibodies and synergistic effect of cyclosporin A. Dev Biol Stand. 1988; 69:177-84.
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  345. Knudsen PJ, Dinarello CA, Strom TB. Glucocorticoids inhibit transcriptional and post-transcriptional expression of interleukin 1 in U937 cells. J Immunol. 1987 Dec 15; 139(12):4129-34.
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  346. Tilney NL, Strom TB, Kupiec-Weglinski JW. Humoral and cellular mechanisms in acute allograft injury. J Pediatr. 1987 Dec; 111(6 Pt 2):1000-3.
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  347. Williams DP, Parker K, Bacha P, Bishai W, Borowski M, Genbauffe F, Strom TB, Murphy JR. Diphtheria toxin receptor binding domain substitution with interleukin-2: genetic construction and properties of a diphtheria toxin-related interleukin-2 fusion protein. Protein Eng. 1987 Dec; 1(6):493-8.
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  348. Loertscher R, Abbud-Filho M, Leichtman AB, Ythier AA, Williams JM, Carpenter CB, Strom TB. Differential effect of gamma-irradiated and heat-treated lymphocytes on T cell activation, and interleukin-2 and interleukin-3 release in the human mixed lymphocyte reaction. Transplantation. 1987 Nov; 44(5):673-80.
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  349. Padberg WM, Di Stefano R, Lord RH, Araneda D, Strom TB, Diamantstein T, Tilney NL, Kupiec-Weglinski JW. Synergy between cyclosporine and other immunosuppressive regimens in experimental organ transplantation. Transplant Proc. 1987 Oct; 19(5):4234-5.
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  350. Padberg WM, Lord RH, Kupiec-Weglinski JW, Williams JM, Di Stefano R, Thornburg LE, Araneda D, Strom TB, Tilney NL. Two phenotypically distinct populations of T cells have suppressor capabilities simultaneously in the maintenance phase of immunologic enhancement. J Immunol. 1987 Sep 15; 139(6):1751-7.
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  351. Loertscher R, Williams JM, Guttmann RD, Strom TB. Modification of the mixed lymphocyte reaction by alloactivated suppressor T lymphocytes and exogenous interleukin-2. Transplant Proc. 1987 Aug; 19(4):3385-7.
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  352. Kelley VE, Gaulton GN, Strom TB. Inhibitory effects of anti-interleukin 2 receptor and anti-L3T4 antibodies on delayed type hypersensitivity: the role of complement and epitope. J Immunol. 1987 May 1; 138(9):2771-5.
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  353. Kupiec-Weglinski JW, Padberg W, Uhteg LC, Ma L, Lord RH, Araneda D, Strom TB, Diamantstein T, Tilney NL. Selective immunosuppression with anti-interleukin 2 receptor-targeted therapy: helper and suppressor cell activity in rat recipients of cardiac allografts. Eur J Immunol. 1987 Mar; 17(3):313-9.
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  354. Shapiro ME, Kirkman RL, Reed MH, Puskas JD, Mazoujian G, Letvin NL, Carpenter CB, Milford EL, Waldmann TA, Strom TB, et al. Monoclonal anti-IL-2 receptor antibody in primate renal transplantation. Transplant Proc. 1987 Feb; 19(1 Pt 1):594-8.
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  355. Strom TB. The immunopharmacology of graft rejection. Transplant Proc. 1987 Feb; 19(1 Pt 1):128-9.
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  356. Milford EL, Carpenter CB, Kirkman RL, Tilney NL, Mazoujian G, Strom TB, Lazarus JM, Schlossman SF, Guttmann RD, Lowry R, et al. Anti-T12 monoclonal antibody therapy of acute renal allograft rejection. Transplant Proc. 1987 Feb; 19(1 Pt 3):1910.
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  357. Kupiec-Weglinski JW, Padberg W, Uhteg LC, Towpik E, Lord RH, Ma L, Diamantstein T, Strom TB, Tilney NL. Anti-interleukin-2 receptor (IL-2R) antibody against rejection of organ grafts. Transplant Proc. 1987 Feb; 19(1 Pt 1):591-3.
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  358. Melton LB, Lakkis FG, Deloria D, Williams JW, Strom TB. Requirements for primary T cell activation. Transplant Proc. 1987 Feb; 19(1 Pt 1):331-2.
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  359. Kelley VE, Strom TB. Immunosuppression by anti-interleukin-2 receptor antibody but not anti-L3T4 requires terminal complement components. Transplant Proc. 1987 Feb; 19(1 Pt 1):617.
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  360. Syndman DR, Werner BG, Heinze-Lacey B, Berardi VP, Tilney NL, Kirkman RL, Milford EL, Cho SI, Bush HL Jr, Levey AS, Strom TB, Carpenter CB, Levey RH, Harmon WE, Zimmerman II CE, Shapiro ME, Steinman T, LoGerfo F, Idelson B, Schroter GPJ, Levin MJ, McIver J, Leszczynski, Grady GF. Use of cytomegalovirus immune globulin to prevent cytomegalovirus disease in renal transplant recipients. N Engl J Med. 1987; 317:1049-54.
  361. Murphy JR, Bishai W, Williams D, Bacha P, Borowski M, Parker K, Boyd J, Waters C, Strom TB. Genetic assembly and selective toxicity of diphtheria-toxin-related polypeptide hormone fusion proteins. Biochem Soc Symp. 1987; 53:9-23.
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  362. Diamantstein T, Osawa H, Kirkman RL, Shapiro ME, Strom TB, Tilney NL, Kupiec-Weglinski JW. Interleukin 2 receptor--a target for immunosuppressive therapy. Transplant Rev (Orlando). 1987; 1:177-96.
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  363. Williams JM, Kelley VE, Kirkman RL, Tilney NL, Shapiro ME, Murphy JR, Strom TB. T cell activation antigens: therapeutic implications. Immunol Invest. 1987-1988 Dec; 16(8):687-723.
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  364. Weil J, Bidlingmaier F, Döhlemann C, Kuhnle U, Strom T, Lang RE. Comparison of plasma atrial natriuretic peptide levels in healthy children from birth to adolescence and in children with cardiac diseases. Pediatr Res. 1986 Dec; 20(12):1328-31.
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  365. Knudsen PJ, Dinarello CA, Strom TB. Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate. J Immunol. 1986 Nov 15; 137(10):3189-94.
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  366. Kelley VE, Naor D, Tarcic N, Gaulton GN, Strom TB. Anti-interleukin 2 receptor antibody suppresses delayed-type hypersensitivity to foreign and syngeneic antigens. J Immunol. 1986 Oct 1; 137(7):2122-4.
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  367. Kelley VE, Strom TB. Spleen cell factor inhibits lymphoproliferation, abnormal Ia expression and overt autoimmunity in MRL-lpr mice. Clin Immunol Immunopathol. 1986 Oct; 41(1):145-53.
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  368. Schneider TM, Kupiec-Weglinski JW, Towpik E, Padberg W, Araneda D, Diamantstein T, Strom TB, Tilney NL. Development of suppressor lymphocytes during acute rejection of rat cardiac allografts and preservation of suppression by anti-IL-2-receptor monoclonal antibody. Transplantation. 1986 Aug; 42(2):191-6.
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  369. Surman OS, Williams J, Sheehan DV, Strom TB, Jones KJ, Coleman J. Immunological response to stress in agoraphobia and panic attacks. Biol Psychiatry. 1986 Jul; 21(8-9):768-74.
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  370. Knudsen PJ, Dinarello CA, Strom TB. Purification and characterization of a unique human interleukin 1 from the tumor cell line U937. J Immunol. 1986 May 1; 136(9):3311-6.
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  371. Abbud-Filho M, Ransil BJ, Kelley VE, Fiers W, Strom TB. Natural killer cell response to interferons. Clin Immunol Immunopathol. 1986 May; 39(2):264-76.
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  372. Kelley VE, Farber NM, Williams JM, Strom TB. Inability of autoimmune mice with the lpr gene to spontaneously produce interleukin 3. Eur J Immunol. 1986 Apr; 16(4):464-7.
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  373. Kupiec-Weglinski JW, Diamantstein T, Tilney NL, Strom TB. Therapy with monoclonal antibody to interleukin 2 receptor spares suppressor T cells and prevents or reverses acute allograft rejection in rats. Proc Natl Acad Sci U S A. 1986 Apr; 83(8):2624-7.
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  374. Tilney NL, Milford EL, Carpenter CB, Lazarus JM, Strom TB, Kirkman RL. Long-term results of cyclosporine treatment in renal transplantation. Transplant Proc. 1986 Apr; 18(2 Suppl 1):179-85.
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  375. Schneider TM, Kupiec-Weglinski JW, Towpik E, Strom TB, Tilney NL. Studies on mechanisms of acute rejection of vascularized organ allografts. Hum Immunol. 1986 Mar; 15(3):320-9.
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  376. Miller RA, Rozans MK, Ythier AA, Strom TB. Stages of T cell activation: continued antigen dependence of IL 2-producing cells after IL 2 receptor expression. J Immunol. 1986 Feb 1; 136(3):977-83.
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  377. Bach JF, Strom TB. The Mode of Action of Immunosuppressive Agents. 1986.
  378. Strom TB, Gaulton GN, Kelley VE, Diamanstein T, Kupiec-Weglinski J, Tilney NL, Kirkman RL. Treatment with anti-interleukin-2 receptor monoclonal antibody. Prog Clin Biol Res. 1986; 224:227-38.
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  379. Tilney NL, Kupiec-Weglinski J, Strom TB. T cells and their products in host responsiveness to organ allografts. Prog Clin Biol Res. 1986; 224:21-39.
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  380. Maddock EO, Maddock SW, Kelley VE, Strom TB. Rapid stereospecific stimulation of lymphocytic metabolism by interleukin 2. J Immunol. 1985 Dec; 135(6):4004-8.
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  381. Kirkman RL, Barrett LV, Gaulton GN, Kelley VE, Koltun WA, Schoen FJ, Ythier A, Strom TB. The effect of anti-interleukin-2 receptor monoclonal antibody on allograft rejection. Transplantation. 1985 Dec; 40(6):719-22.
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  382. Hafler DA, Hemler ME, Christenson L, Williams JM, Shapiro HM, Strom TB, Strominger JL, Weiner HL. Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clin Immunol Immunopathol. 1985 Nov; 37(2):163-71.
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  383. Weir MR, Kirkman RL, Strom TB, Tilney NL. Liver disease in recipients of long-functioning renal allografts. Kidney Int. 1985 Nov; 28(5):839-44.
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  384. Williams JM, Deloria D, Hansen JA, Dinarello CA, Loertscher R, Shapiro HM, Strom TB. The events of primary T cell activation can be staged by use of Sepharose-bound anti-T3 (64.1) monoclonal antibody and purified interleukin 1. J Immunol. 1985 Oct; 135(4):2249-55.
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  385. Ythier AA, Abbud-Filho M, Williams JM, Loertscher R, Schuster MW, Nowill A, Hansen JA, Maltezos D, Strom TB. Interleukin 2-dependent release of interleukin 3 activity by T4+ human T-cell clones. Proc Natl Acad Sci U S A. 1985 Oct; 82(20):7020-4.
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  386. Heidecke CD, Araujo JL, Kupiec-Weglinski JW, Abbud-Filho M, Araneda D, Stadler J, Siewert J, Strom TB, Tilney NL. Lack of evidence for an active role for natural killer cells in acute rejection of organ allografts. Transplantation. 1985 Oct; 40(4):441-4.
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  387. Williams JM, Abbud-Filho M, Kelley VE, Strom TB. Interleukin-2 apparently upregulates its receptor and induces proliferation of various resting mononuclear leukocytes in the absence of antigen. Cell Immunol. 1985 Sep; 94(2):383-93.
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  388. Carpenter CB, Milford EL, Kirkman RL, Strom TB, Lazarus JM, Tilney NL. Stability of renal allograft recipients after conversion from cyclosporine to azathioprine. Transplant Proc. 1985 Aug; 17(4 Suppl 1):261-5.
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  389. Kirkman RL, Barrett LV, Gaulton GN, Kelley VE, Ythier A, Strom TB. Administration of an anti-interleukin 2 receptor monoclonal antibody prolongs cardiac allograft survival in mice. J Exp Med. 1985 Jul 1; 162(1):358-62.
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  390. Gaulton GN, Bangs J, Maddock S, Springer T, Eardley DD, Strom TB. Characterization of a monoclonal rat anti-mouse interleukin 2 (IL-2) receptor antibody and its use in the biochemical characterization of the murine IL-2 receptor. Clin Immunol Immunopathol. 1985 Jul; 36(1):18-29.
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  391. Kupiec-Weglinski JW, Heidecke CD, Araujo JL, Abbud-Filho M, Towpik E, Araneda D, Strom TB, Tilney NL. Behavior of helper T lymphocytes in cyclosporine-mediated long-term graft acceptance in the rat. Cell Immunol. 1985 Jun; 93(1):168-77.
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  392. Milford EL, Kirkman RL, Tilney NL, Strom TB, Carpenter CB. Clinical experience with cyclosporine and azathioprine at Brigham and Women's Hospital. Am J Kidney Dis. 1985 Jun; 5(6):313-7.
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  393. Ythier AA, Williams JM, Shapiro HM, Kelley VE, Strom TB. The early (18-hr) human mixed lymphocyte reaction: identification and isolation of activated T-cell clones. Cell Immunol. 1985 Mar; 91(1):215-26.
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  394. Kelley VE, Ferretti A, Izui S, Strom TB. A fish oil diet rich in eicosapentaenoic acid reduces cyclooxygenase metabolites, and suppresses lupus in MRL-lpr mice. J Immunol. 1985 Mar; 134(3):1914-9.
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  395. Williams JM, Dinarello CA, Rosenwasser LJ, Kelley V, Reddish M, Strom TB. Phorbol myristate acetate-protein complex mimics bioactivity of human IL-1. 1. Direct evidence that PMA temporarily enters and is released from cellular compartment during superinduction protocol. Lymphokine Res. 1985; 4(4):275-97.
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  396. Knudsen PJ, Strom TB. Elevated intracellular cAMP levels inhibit interleukin 1 production by the tumor line U 937. Brit J Rheum. 1985; 24:65-8.
  397. Heagy W, Kelley VE, Strom TB, Mayer K, Shapiro HM, Mandel R, Finberg R. Decreased expression of human class II antigens on monocytes from patients with acquired immune deficiency syndrome. Increased expression with interferon-gamma. J Clin Invest. 1984 Dec; 74(6):2089-96.
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  398. Williams JM, Ransil BJ, Shapiro HM, Strom TB. Accessory cell requirement for activation antigen expression and cell cycle progression by human T lymphocytes. J Immunol. 1984 Dec; 133(6):2986-95.
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  399. Rocher LL, Milford EL, Kirkman RL, Carpenter CB, Strom TB, Tilney NL. Conversion from cyclosporine to azathioprine in renal allograft recipients. Transplantation. 1984 Dec; 38(6):669-74.
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  400. Tilney NL, Milford EL, Araujo JL, Strom TB, Carpenter CB, Kirkman RL. Experience with cyclosporine and steroids in clinical renal transplantation. Ann Surg. 1984 Nov; 200(5):605-13.
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  401. Abbud-Filho M, Kupiec-Weglinski JW, Araujo JL, Heidecke CD, Tilney NL, Strom TB. Cyclosporine therapy of rat heart allograft recipients and release of interleukins (IL 1, IL 2, IL 3): a role for IL 3 in graft tolerance? J Immunol. 1984 Nov; 133(5):2582-6.
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  402. Cohen DJ, Loertscher R, Rubin MF, Tilney NL, Carpenter CB, Strom TB. Cyclosporine: a new immunosuppressive agent for organ transplantation. Ann Intern Med. 1984 Nov; 101(5):667-82.
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  403. Strom TB, Loertscher R. Cyclosporin-induced nephrotoxicity. Inevitable and intractable? N Engl J Med. 1984 Sep 13; 311(11):728-9.
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  404. Strom TB. Immunosuppressive agents in renal transplantation. Kidney Int. 1984 Sep; 26(3):353-65.
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  405. Heidecke CD, Kupiec-Weglinski JW, Lear PA, Abbud-Filho M, Araujo JL, Araneda D, Strom TB, Tilney NL. Interactions between T lymphocyte subsets supported by interleukin 2-rich lymphokines produce acute rejection of vascularized cardiac allografts in T cell deprived rats. J Immunol. 1984 Aug; 133(2):582-8.
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  406. Kupiec-Weglinski JW, Filho MA, Strom TB, Tilney NL. Sparing of suppressor cells: a critical action of cyclosporine. Transplantation. 1984 Aug; 38(2):97-101.
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  407. Williams JM, Loertscher R, Cotner T, Reddish M, Shapiro HM, Carpenter CB, Strominger JL, Strom TB. Dual parameter flow cytometric analysis of DNA content, activation antigen expression, and T cell subset proliferation in the human mixed lymphocyte reaction. J Immunol. 1984 May; 132(5):2330-7.
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  408. Tilney NL, Rocha A, Strom TB, Kirkman RL. Renal artery stenosis in transplant patients. Ann Surg. 1984 Apr; 199(4):454-60.
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  409. Carpenter CB, Ettenger RB, Strom TB. "Free-market" approach to organ donation. N Engl J Med. 1984 Feb 9; 310(6):395-6.
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  410. Tilney NL, Kupiec-Weglinski JW, Heidecke CD, Lear PA, Strom TB. Mechanisms of rejection and prolongation of vascularized organ allografts. Immunol Rev. 1984; 77:185-216.
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  411. Kelley VE, Fiers W, Strom TB. Cloned human interferon-gamma, but not interferon-beta or -alpha, induces expression of HLA-DR determinants by fetal monocytes and myeloid leukemic cell lines. J Immunol. 1984 Jan; 132(1):240-5.
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  412. Carpenter CB, Strom TB. Immunosuppressive therapy for renal transplantation. Springer Semin Immunopathol. 1984; 7(1):43-57.
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  413. Kirkman RL, Araujo JL, Busch GJ, Carpenter CB, Milford EL, Reinherz EL, Schlossman SF, Strom TB, Tilney NL. Treatment of acute renal allograft rejection with monoclonal anti-T12 antibody. Transplantation. 1983 Dec; 36(6):620-6.
    View in: PubMed
  414. Shapiro HM, Glazer AN, Christenson L, Williams JM, Strom TB. Immunofluorescence measurement in a flow cytometer using low-power helium-neon laser excitation. Cytometry. 1983 Nov; 4(3):276-9.
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  415. Lear PA, Heidecke CD, Kupiec-Weglinski JW, Araneda D, Strom TB, Tilney NL. Restoration of allograft responsiveness in B rats. II. Requirements for lymphoid populations and lymphokine. Transplantation. 1983 Oct; 36(4):412-7.
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  416. Wang BS, Zheng CX, Heacock EH, Tilney NL, Strom TB, Mannick JA. Inhibition of the production of a soluble helper mediator by cyclosporin A results in the failure to generate alloreactive cytolytic cells in mixed-lymphocyte culture. Clin Immunol Immunopathol. 1983 May; 27(2):160-9.
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  417. Kaldany A, George K, Suthanthiran M, Catto GR, Strom TB, Carpenter CB. Long-term renal allograft survival in rats preimmunized with donor strain RT1.B antigens. Transplantation. 1983 Apr; 35(4):289-93.
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  418. Strom TB, Carpenter CB. Prostaglandin as an effective antirejection therapy in rat renal allograft recipients. Transplantation. 1983 Apr; 35(4):279-81.
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  419. Cotner T, Williams JM, Christenson L, Shapiro HM, Strom TB, Strominger J. Simultaneous flow cytometric analysis of human T cell activation antigen expression and DNA content. J Exp Med. 1983 Feb 1; 157(2):461-72.
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  420. Bordes-Aznar J, Kupiec-Weglinski JW, Duarte AJ, Milford EL, Strom TB, Tilney NL. Function and migration of suppressor lymphocytes from cyclosporine-treated heart graft recipients. Transplantation. 1983 Feb; 35(2):185-90.
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  421. Strom TB, Carpenter CB. Transplantation: immunogenetic and clinical aspects--part II. Hosp Pract (Off Ed). 1983 Jan; 18(1):135-9, 142-7, 150.
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  422. Carpenter CB, Milford EL, Reinherz EL, Schlossman SF, Tilney NL, Strom TB, Kirkman RL, Busch GJ, Araujo JL. Monoclonal anti-T12 antibody as therapy for renal allograft rejection. Trans Assoc Am Physicians. 1983; 96:84-92.
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  423. Carpenter CB, Strom TB. Transplantation: immunogenetic and clinical aspects--Part I. Hosp Pract (Off Ed). 1982 Dec; 17(12):125-34.
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  424. Gozes Y, Moskowitz MA, Strom TB, Gozes I. Conditioned media from activated lymphocytes maintain sympathetic neurons in culture. Brain Res. 1982 Dec; 282(1):93-7.
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  425. Kirkman RL, Strom TB, Weir MR, Tilney NL. Late mortality and morbidity in recipients of long-term renal allografts. Transplantation. 1982 Dec; 34(6):347-51.
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  426. Strom TB. Editorial retrospective: hepatitis B, transfusions, and renal transplantation -- five years later. N Engl J Med. 1982 Oct 28; 307(18):1141-2.
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  427. Clason AE, Duarte AJ, Kupiec-Weglinski JW, Williams JN, Wang BS, Strom TB, Tilney NL. Restoration of allograft responsiveness in B rats by interleukin 2 and/or adherent cells. J Immunol. 1982 Jul; 129(1):252-9.
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  428. Strom TB. The improving utility of renal transplantation in the management of end-stage renal disease. Am J Med. 1982 Jul; 73(1):105-24.
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  429. Williams JM, Shapiro HM, Milford EL, Strom TB. Multiparameter flow cytometric analysis of lymphocyte subpopulation activation in lectin-stimulated cultures. J Immunol. 1982 Jun; 128(6):2676-81.
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  430. Kupiec-Weglinski JW, Bordes-Aznar J, Clason AE, Duarte AJ, Araneda D, Carpenter CB, Strom TB, Tilney NL. Migration patterns of lymphocytes in untreated and immunologically manipulated recipients of organ allografts. Transplantation. 1982 Jun; 33(6):593-8.
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  431. Strom TB, Bangs JD. Human serum-free mixed lymphocytes response: the stereospecific effect of insulin and its potentiation by transferrin. J Immunol. 1982 Apr; 128(4):1555-9.
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  432. Wang BS, Heacock EH, Chang-Xue Z, Tilney NL, Strom TB, Mannick JA. Evidence for the presence of suppressor T lymphocytes in animals treated with cyclosporin A. J Immunol. 1982 Mar; 128(3):1382-5.
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  433. Duarte AJ, Carpenter CB, Strom TB. Expression of T cell differentiation antigens and Ia on rat cytotoxic T lymphocytes. J Immunol. 1982 Feb; 128(2):580-4.
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  434. Tilney NL, Kohler TR, Strom TB. Cerebromeningitis in immunosuppressed recipients of renal allografts. Ann Surg. 1982 Jan; 195(1):104-9.
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  435. Hutchinson IF, Shadur CA, Duarte JS, Strom TB, Tilney NL. Cyclosporin A spares selectively lymphocytes with donor-specific suppressor characteristics. Transplantation. 1981 Sep; 32(3):210-6.
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  436. Strom TB, Lane MA, George K. The parallel, time-dependent, bimodal change in lymphocyte cholinergic binding activity and cholinergic influence upon lymphocyte-mediated cytotoxicity after lymphocyte activation. J Immunol. 1981 Aug; 127(2):705-10.
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  437. Strom TB, Garovoy MR. Clinical and experimental aspects of renal allograft rejection. Am J Kidney Dis. 1981 Jul; 1(1):5-14.
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  438. Shadur CA, Strom TB, Carpenter CB. In vitro generation of suppressor lymphocytes with subcellular membrane fragments. Transplant Proc. 1981 Jun; 13(2):1472-5.
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  439. Norman DJ, Black RM, Shadur CA, Strom TB, Carpenter CB. Continuous density gradient separation of allosensitized cells from a mixed lymphocyte culture. Transplant Proc. 1981 Jun; 13(2):1469-71.
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  440. Lowry RP, Shadur CA, Duarte A, Strom TB, Carpenter CB. Lymphocyte subsets in heart allograft rejection in a rat model: effect of in vitro generated suppressor cells. Transplant Proc. 1981 Jun; 13(2):1428-31.
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  441. Sheehy MJ, Miller NJ, Rappeport JM, Gozes Y, Parkman R, Strom TB, Yunis EJ. A patient with post-hepatitis B immune deficiency: nonspecific helper factor partially restores the in vitro immune response. Vox Sang. 1981 May; 40(5):346-51.
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  442. Gozes Y, Caruso J, Strom TB. The absence of cryptic insulin receptors on resting lymphocytes. Diabetes. 1981 Apr; 30(4):314-6.
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  443. Hutchinson IF, Shadur CA, Duarte A, Baldwin WM, Strom TB, Tilney NL. Mechanisms of cardiac allograft prolongation by cyclosporin-A. Transplant Proc. 1981 Mar; 13(1 Pt 1):412-3.
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  444. Milford EL, Carpenter CB, Strom TB, Tilney NL. Suppression of renal allograft rejection by low density thymocytes. Transplant Proc. 1981 Mar; 13(1 Pt 1):626-8.
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  445. Helderman JH, Garovoy MR, Strom TB. B-cell alloantigen matching by the lymphocyte insulin receptor assay. Transplant Proc. 1981 Mar; 13(1 Pt 2):1042-3.
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  446. Wilson RE, Garovoy MR, Strom TB, Lowry RP, Busch GJ, Vineyard GC, Tilney NL. Passive enhancement of cadaver renal allografts: a prospective randomized trial of F(ab')2 therapy. Transplant Proc. 1981 Mar; 13(1 Pt 1):531-2.
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  447. Helderman JH, Strom TB, Garovoy MR. Rapid mixed lymphocyte culture testing by analysis of the insulin receptor on alloactivated T lymphocytes: implications for human tissue typing. J Clin Invest. 1981 Feb; 67(2):509-13.
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  448. Tilney NL, MacLennon I, Strom TB, Baldwin WM. Effects of thymectomy, thoracic duct drainage, and radiation of T and B lymphocyte distribution and cardiac allograft survival in rats. Transplantation. 1981 Jan; 31(1):26-30.
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  449. Strom TB, Tilney NL, Carpenter CB. Kidney transplantation in the treatment of terminal uremia. Ann Clin Res. 1981; 13(4-5):224-43.
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  450. Strom TB, Helderman JH. Comparison of ligand-specific rat allosensitized lymphocyte insulin receptors as assessed in binding and functional (lymphocyte-mediated cytotoxicity) assays. Cell Immunol. 1980 Aug 1; 53(2):382-8.
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  451. Shapiro HM, Strom TB. Electrophysiology of T lymphocyte cholinergic receptors. Proc Natl Acad Sci U S A. 1980 Jul; 77(7):4317-21.
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  452. Strom TB, Carpenter CB. Cyclic nucleotides in immunosuppression--neuroendocrine pharmacologic manipulation and in vivo immunoregulation of immunity acting via second messenger systems. Transplant Proc. 1980 Jun; 12(2):304-10.
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  453. Kaldany A, Carpenter CB, Shadur CA, George K, Lundin AP, Suthanthiran M, Strom TB. Immunological properties of subcellular rat lymphocyte preparations. Primary allogeneic stimulation in vitro by fractions containing Ia (RT1-B), but not RT1-A antigens. J Exp Med. 1980 Apr 1; 151(4):910-24.
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  454. Tilney NL, Garovoy MR, Busch GJ, Strom TB, Graves MJ, Carpenter CB. Rejected human renal allografts: recovery and characteristics of infiltrating cells and antibody. Transplantation. 1979 Nov; 28(5):421-6.
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  455. Helderman JH, Strom TB. Absence of a role for the cellular exoskeleton in the emergence of the T lymphocyte insulin receptor. Exp Cell Res. 1979 Oct 1; 123(1):119-26.
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  456. Lowry R, Goguen J, Carpenter CB, Strom TB, Garovoy MR. Improved B cell typing for HLA-DR using nylon wool column enriched B lymphocyte preparations. Tissue Antigens. 1979 Oct; 14(4):325-30.
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  457. Helderman JH, Strom TB, Dupuy-D'Angeac A. A close relationship between cytotoxic T lymphocytes generated in the mixed lymphocyte culture and insulin receptor-bearing lymphocytes: enrichment by density gradient centrifugation. Cell Immunol. 1979 Sep 1; 46(2):247-58.
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  458. Helderman JH, Strom TB. Role of protein and RNA synthesis in the development of insulin binding sites on activated thymus-derived lymphocytes. J Biol Chem. 1979 Aug 10; 254(15):7203-7.
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  459. Suthanthiran M, Catto GR, Kaldany A, George K, Garovoy MR, Strom TB, Carpenter CB. Differential antibody responses to Ag-B (A region) and Ia (B region) antigens during enhancement of rat renal allografts. Transplantation. 1979 Jul; 28(1):4-9.
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  460. Hendry W, Tilney NL, Graves MJ, Baldwin WM, Strom TB. Suppressor cells in enhancement of organ allografts. Transplant Proc. 1979 Jun; 11(2):1454-5.
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  461. Helderman JH, Strom TB, Dupuy-D'Angeac A. Analysis of the subpopulations of T blasts bearing insulin receptors obtained by 1-g velocity sedimentation of murine mixed lymphocyte cultures. Transplant Proc. 1979 Jun; 11(2):1385-6.
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  462. Hendry WS, Tilney NL, Baldwin WM, Graves MJ, Milford E, Strom TB, Carpenter CB. Transfer of specific unresponsiveness to organ allografts by thymocytes. Specific unresponsiveness by thymocyte transfer. J Exp Med. 1979 May 1; 149(5):1042-55.
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  463. Milford EL, Carpenter CB, Strom TB, Paradysz JM. MLR-reactive thymocytes in the rat: Ia-positive stimulator and Ia-negative responder cells. Transplant Proc. 1979 Mar; 11(1):719-22.
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  464. Tilney NL, Strom TB, Vineyard GC, Merrill JP. Factors contributing to the declining mortality rate in renal transplantation. N Engl J Med. 1978 Dec 14; 299(24):1321-5.
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  465. Kaldany A, Carpenter CB, Suthanthiran M, Garovoy MR, Strom TB, George K. HLA-D activity in lymphocyte subcellular fractions. Transplant Proc. 1978 Dec; 10(4):785-8.
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  466. Strom TB, Helderman JH, Williams RM. Rapid murine mixed lymphocyte cultures assessed by emergence of T-cell insulin receptors. Immunogenetics. 1978 Dec; 7(1):51-6.
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  467. Tilney NL, Graves MJ, Strom TB. Prolongation of organ allograft survival by syngeneic lymphoid cells. J Immunol. 1978 Oct; 121(4):1480-2.
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  468. Suthanthiran M, Gailiunas P, Fagan G, Strom TB, Carpenter CB, Garovoy MR. Detection of anti-donor "Ia" antibodies: a strong correlate of rejection. Transplant Proc. 1978 Sep; 10(3):605-7.
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  469. Gailiunas P, Suthanthiran M, Person A, Strom TB, Carpenter CB, Garovoy MR. Posttransplant immunologic monitoring of the renal allograft recipient. Transplant Proc. 1978 Sep; 10(3):609-11.
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  470. Tilney NL, Notis-McConarty J, Strom TB. Specificity of cellular migration into cardiac allografts in rats. Transplantation. 1978 Sep; 26(3):181-6.
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  471. Helderman JH, Reynolds TC, Strom TB. The insulin receptor as a universal marker of activated lymphocytes. Eur J Immunol. 1978 Aug; 8(8):589-95.
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  472. Helderman JH, Strom TB. Specific insulin binding site on T and B lymphocytes as a marker of cell activation. Nature. 1978 Jul 6; 274(5666):62-3.
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  473. Strom TB, Carpenter CB, Tilney NL, Suthanthiran M, Catto GR, Lundin AP, Milford EL. Intragraft immune events causing vascularized organ graft rejection. Transplant Proc. 1978 Jun; 10(2):389-94.
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  474. Suthanthiran M, Gailiunas P, Person A, Fagan G, Strom TB, Carpenter CB, Garovoy MR. Accelerated graft loss: association with presensitization to donor B-cell (Ia) antigens. Transplant Proc. 1978 Jun; 10(2):471-3.
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  475. Strom TB. Renal transplantation: A bright outlook. Resident and Staff Physician. 1978; 24:58-68.
  476. Strom TB, Helderman JH, Williams RM. Rapid murine mixed lymphocyte cultures assessed by emergence of T cell insulin receptors. Immunogenetics. 1978; 7:51-56.
  477. Carpenter CB, Catto GRD, Suthanthiran M, Kaldany A, Gailiunas P Jr, Garovoy Mr, Strom TB. Specificity in allograft rejection. Siskind G (ed) Mechanisms in disease. 1978; 105-23.
  478. Strom TB, Kostick R, Tilney NL, Carpenter CB. A characterization of the nature and control of cellular allograft rejection. Nephron. 1978; 22(1-3):201-7.
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  479. Gottlieb MN, Stephens MK, Lowrie EG, Griffiths HJ, Kenzora J, Strom TB, Lazarus JM, Tilney NL, Merrill JP. A longitudinal study of bone disease after successful renal transplantation. Nephron. 1978; 22(1-3):239-48.
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  480. Strom TB, Tilney NL, Paradysz JM, Bancewicz J, Carpenter CB. Cellular components of allograft rejection: identity, specificity, and cytotoxic function of cells infiltrating acutely rejecting allografts. J Immunol. 1977 Jun; 118(6):2020-6.
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  481. Catto GR, Carpenter CB, Strom TB, Williams RM. Passive enhancement of rat renal allografts by antibodies to a non-SD (Ag-B) locus analogous to Ia and demonstration of linkage to the MHC. Transplant Proc. 1977 Mar; 9(1):957-60.
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  482. Strom TB, Soulillou JP, Carpenter CB. On the identity of lymphoid cells that stimulate the rat MLC and produce active enhancement. Transplant Proc. 1977 Mar; 9(1):965-8.
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  483. Tilney NL, Strom TB, Booth DB, Finnegan A, Lundin P, Carpenter CB. Identification, cytotoxicity, and suppressor activity of infiltrating cells from enhanced organ allografts. Transplant Proc. 1977 Mar; 9(1):713-5.
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  484. Busch GJ, Schamberg JF, Moretz RC, Strom TB, Tilney NL, Carpenter CB. Four patterns of human renal allograft rejection: a cytologic and in vitro analysis of the infiltrate in 24 irreversibly rejected kidneys. Transplant Proc. 1977 Mar; 9(1):37-42.
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  485. Fearon DT, Daha MR, Strom TB, Weiler JM, Carpenter CB, Austen KF. Pathways of complement activation in membranoproliferative glomerulonephritis and allograft rejection. Transplant Proc. 1977 Mar; 9(1):729-39.
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  486. Strom TB, Carpenter CB, Cragoe EJ, Norris S, Devlin R, Perper RJ. Suppression of in vivo and in vitro alloimmunity by prostaglandins. Transplant Proc. 1977 Mar; 9(1):1075-9.
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  487. Helderman JH, Strom TB. Emergence of insulin receptors upon alloimmune T cells in the rat. J Clin Invest. 1977 Feb; 59(2):338-44.
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  488. Strom TB, Merrill JP. Hepatitis B, transfusions and renal transplantation. N Engl J Med. 1977 Jan 27; 296(4):225-6.
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  489. Strom TB, Helderman JH, Williams RM. Rapid murine mixed lymphocyte cultures assessed by emergence of T cell insulin receptors. Proc Clin Dial Transplant Forum. 1977; 7:148-51.
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  490. Strom TB, Lundin AP, Carpenter CB. The role of cyclic nucleotides in lymphocyte activation and function. Prog Clin Immunol. 1977; 3:115-53.
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  491. Lundin AP III, Kaldany A, Strom TB, Soulillou JP, Carpenter CB. Role of rat lymphocyte subpopulations in the mixed lymphocyte culture. Role of rat lymphocyte subpopulations in the mixed lymphocyte culture. Lucas DO, ed. Proceedings of the Eleventh Leukocyte Culture Conference. (Regulatory Mechanisms in Lymphocyte Activation). 1977; 611-13.
  492. Lundin AP III, Kaldany A, Strom TB, Tilney NL, Carpenter CB. Presence of splenic suppressor cells in allograft enhanced rats. Lucas DO, ed. Proceedings of the Eleventh Leukocyte Culture Conference (Regulatory Mechanisms in Lymphocyte Activation). 1977; 803-05.
  493. Gottlieb MN, Stephens MK, Lowrie EG, Griffiths NJL, Kenzora JR, Strom TB, Phillips E, Merrill JP. Bone disease following renal transplantation. Calcium metabolism in renal disease and nephrolithiasis. 1977; 279-92.
  494. Helderman JH, Strom TB. The insulin receptor on the T cell: a marker of activation after stimulation. Lucas DO, ed. Proceedings of the Eleventh Leukocyte Culture Conference (Regulatory Mechanisms in Lymphrocyte Activation). 1977; 343-35.
  495. Hoette M, Kaldany A, Lundin AP III, Gottlieb MN, Suthanthiran M, Carpenter CB, Strom TB. In vitro modulation of phytohemagglutin-P induced blastogenesis by parathyroid hormone. Lucas DO, ed. Proceedings of the Eleventh Leukocyte Culture Conference (Regulatory Mechanisms in Lymphocyte Activation). 1977; 453-5.
  496. Lundin AP III, Kaldany A, Paradysz JM, Carpenter CB, Strom TB. Characterization of the adherent splenic suppressor cells. Lucas DO, ed. Proceedings of the Eleventh Leukocyte Culture Conference (Regulatory Mechanisms in Lymphocyte Activation). 1977; 800-82.
  497. Kaldany A, Lundin AP III, George K, Suthanthiran M, Carovoy MR, Carpenter CB, Strom TB. In vitro stimulation of unprimed lymphocyte membrane fragments. Lucas DO, ed. Proceedings of the Eleventh Leukocyte Culture Conference (Regulatory Mechanisms in Lymphocyte Activation). 1977; 397-9.
  498. Strom TB, Carpenter CB. Regulation of alloimmunity by cyclic nucleotides. Immunopharmacology-Comprehensive Immunology Hadden JW, Spreafico F, Grattini S, eds. 1977; 3:47-59.
  499. Rogers MP, Reich P, Strom TB, Carpenter CB. Behaviorally conditioned immunosuppression: replication of a recent study. Psychosom Med. 1976 Nov-Dec; 38(6):447-51.
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  500. Helderman JH, Strom TB. The insulin receptor: a marker of T cell activation after allograft. Proc Clin Dial Transplant Forum. 1976 Nov 19-22; 6:154-8.
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  501. Garovoy MR, Strom TB, Gribik M, Carpenter CB. Antibody-dependent lymphocyte-mediated cytotoxicity (Ab-LMC), definition of the "K cell" in the rat. Transplantation. 1976 Oct; 22(4):367-73.
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  502. Busch GJ, Schamberg JF, Moretz RC, Strom TB, Tilney NL, Carpenter CB. T and B cell patterns in irreversibly rejected human renal allografts. Correlation of morphology with surface markers and cytotoxic capacity of the isolated lymphoid infiltrates. Lab Invest. 1976 Sep; 35(3):272-80.
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  503. Carpenter CB, Soulillou JP, D'Apice AJ, Strom TB, Garovoy MR. The role of antibodies in the rejection and enhancement of rat organ allografts: non-Ag-B (Ia) antigens. Transplant Proc. 1976 Jun; 8(2):199-205.
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  504. Soulillou JP, Carpenter CB, d'Apice AJ, Strom TB. The role of nonclassical Fc receptor-associated, Ag-B antigens (Ia) in rat allograft enhancement. J Exp Med. 1976 Feb 1; 143(2):405-21.
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  505. Tilney NL, Strom TB, Macpherson SG, Carpenter CB. Studies on infiltrating host cells harvested from acutely rejecting rat cardiac allografts. Surgery. 1976 Feb; 79(02):209-17.
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  506. Strom TB, Garovoy MR, Carpenter CB. Pharmacologic modulation of cytotoxic lymphocytes by cyclic nucleotides. International Course on Transplantation . 1976; 85-96.
  507. Pletka PG, Strom TB, Hampers CL, Griffiths H, Wilson RE, Bernstein DS, Sherwood LM, Merrill JP. Secondary hyperparathyroidism in human kidney transplant recipients. Nephron. 1976; 17(5):371-81.
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  508. Strom TB, Garovoy MR, Bear RA, Gribik M, Carpenter CB. A comparison of the effects of metabolic inhibitors upon direct and antibody-dependent lymphocyte mediated cytotoxicity. Cell Immunol. 1975 Dec; 20(2):247-56.
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  509. Garovoy MR, Strom TB, Kaliner M, Carpenter CB. Antibody-dependent lymphocyte mediated cytotoxicity mechanism and modulation by cyclic nucleotides. Cell Immunol. 1975 Dec; 20(2):197-204.
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  510. Soulillou JP, Carpenter CB, Lundin AP, Strom TB. Augmentation of proliferation and in vitro production of cytotoxic cells by 2-ME in the rat. J Immunol. 1975 Dec; 115(6):1566-71.
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  511. Strom TB, Carpenter CB, Garovoy MR, Abbas AK, Corson JM, Bear RA, Soulillou JP. Modification of the rat alloimmune response by enhancing antibodies and the role of blocking factors in the survival of renal grafts. Transplantation. 1975 Nov; 20(5):368-80.
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  512. Tilney NL, Strom TB, Macpherson SG, Carpenter CB. Surface properties and functional characteristics of infiltrating cells harvested from acutely rejecting cardiac allografts in inbred rats. Transplantation. 1975 Oct; 20(4):323-30.
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  513. Strom TB, Tilney NL, Carpenter CB, Busch GJ. Identity and cytotoxic capacity of cells infiltrating renal allografts. N Engl J Med. 1975 Jun 12; 292(24):1257-63.
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  514. Abbas AK, Corson JM, Carpenter CB, Strom TB, Merrill JP, Dammin GJ. Immunologic enhancement of rat renal allografts. III. Immunopathologic lesions and rejection in long-surviving passively enhanced grafts. Am J Pathol. 1975 May; 79(2):255-70.
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  515. Strom TB, Bear RA, Carpenter CB. Insulin-induced augmentation of lymphocyte-mediated cytotoxicity. Science. 1975 Mar 28; 187(4182):1206-8.
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  516. Macpherson SG, Tilney NL, Strom TB, Carpenter CB. Proceedings: Nature of cells removed from rejecting rat cardiac allografts;. Br J Surg. 1975 Feb; 62(2):155.
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  517. Hurst KS, Saldanha LF, Steinberg SM, Galen MA, Lowrie EG, Gagneux SA, Lazarus JM, Strom TB, Carpenter CB, Merrill JP. The effects of varying dialysis regimens on lymphocyte stimulation. Trans Am Soc Artif Intern Organs. 1975; 21:329-34.
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  518. Strom TB, Hirsch MS, Black PH, Carpenter CB, Merrill JP. Modulation of GVH proliferation by cyclic nucleotides. Transplant Proc. 1975; 7:305-7.
  519. Tilney NL, Strom TB, Bancewicz J, Carpenter CB. Studies on living cells harvested from acutely rejecting and enhanced rat cardiac allografts. Surg Forum. 1975; 26:349-50.
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  520. Wilson RE, Goldman MH, Yen MC, Kassissieh SD, Strom T, Kahn CB. Neuropathy in transplanted diabetic patients. Kidney Int Suppl. 1974 Oct; (1):90-4.
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  521. Strom TB, Sytkowski AJ, Carpenter CB, Merrill JP. Cholinergic augmentation of lymphocyte-mediated cytotoxicity. A study of the cholinergic receptor of cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1974 Apr; 71(4):1330-3.
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  522. Strom TB, Deisseroth A, Morganroth J, Carpenter CB, Merrill JP. Modulation of cytotoxic T lymphocyte function by cyclic 3', 5' mononucleotides. Braun W, Lichtenstein LM, Parker CW (eds) Cyclic AMP, Cell Growth, and the Immune Response. 1974; 209-22.
  523. Strom TB, Sytkowski AJ, Carpenter CB, Merrill JP. The cholingergic receptor of cytotoxic lymphocytes. Proceedings of the Eigth Leukocyte Culture Conference - Lymphocyte Recognition and Effector Mechanisms. 1974; 509-13.
  524. Carpenter CB, Garovoy MR, Strom TB, Merrill JP. Antibody dependent lymphocyte-mediated cytotoxicity. Role of cyclic nucleotides in the injury produced by unsensitized bone marrow derived (B) cells. Proceedings of the Eighth Leukocyte Culture Conference (Lymphocyte Recognition and Effector Mechanisms). 1974; 351-56.
  525. Tilney NL, Strom TB, Macpherson SG, Carpenter CB. Populations of infiltrating cells removed from rejecting rat cardiac allografts. Surg Forum. 1974; 25(0):289-92.
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  526. Phillips SM, Carpenter CB, Strom TB. Cellular immunity in the mouse. 3. In vitro kinetic studies on the relationship between recognition and effector phases. Transplant Proc. 1973 Dec; 5(4):1669-73.
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  527. Strom TB, Carpenter CB, Garovoy MR, Austen KF, Merrill JP, Kaliner M. The modulating influence of cyclic nucleotides upon lymphocyte-mediated cytotoxicity. J Exp Med. 1973 Aug 1; 138(2):381-93.
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  528. Strom TB, Carpenter CB, Phillips SM, Garovoy MR, Merrill JP. Rejection and enhancement in an in vitro model of alloimmunity. Transplantation. 1973 Aug; 16(2):103-9.
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  529. Strom TB, Garovoy MR, Carpenter DB, Merrill JP. Microtubule function in immune and nonimmune lymphocyte-mediated cytotoxicity. Science. 1973 Jul 13; 181(4095):171-3.
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  530. Garovoy MR, Franco V, Zschaeck D, Carpenter CB, Strom TB, Merrill JP. Derect lymphocyte-mediated cytotoxicity as an assay of presensitisation. Lancet. 1973 Mar 17; 1(7803):573-6.
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  531. Strom TB, Deisseroth A, Morgenroth J, Carpenter CB, Merrill JP. Regulatory role of the cyclic nucleotides in alloimmune lymphocyte mediated cytotoxicity. Effect of imidazole. Transplant Proc. 1973 Mar; 5(1):425-7.
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  532. Phillips SM, Strom TB, Corson JM, Carpenter CB, Merrill JP. Enhancing antibody: in vitro studies on mechanism of action upon the sensitization and effector arc. Transplant Proc. 1973 Mar; 5(1):577-80.
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  533. Philips SM, Strom TB, Corson JM, Carpenter CB, Merrill JP. Enhancing antibody: in vitro studies on the mechanism of action and specificity upon mouse lymphocytes. Proceedings of the Seventh Leukocyte Culture Conference. 1973; 601-11.
  534. Strom TB, Deisseroth A, Morganroth J, Carpenter CB, Merrill JP. Alteration of the cytotoxic action of sensitized lymphocytes by cholinergic agents and activators of adenylate cyclase. Proc Natl Acad Sci U S A. 1972 Oct; 69(10):2995-9.
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  535. Strom T, Muehrcke RC, Smith RD. Sickle cell anemia with the nephrotic syndrome and renal vein obstruction. Arch Intern Med. 1972 Jan; 129(1):104-8.
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  536. Strom TB, Levin BS, Dohrmann GJ, Pollak VE. The effects of antithymocyte globulin in NZB-NZW F1 mice. Proc Soc Exp Biol Med. 1968 Oct; 129(1):261-4.
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