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Zhicheng Lin, PH.D.

TitleAssistant Professor of Psychiatry
InstitutionMcLean Hospital
DepartmentPsychiatry
AddressMclean Hospital
Mrc114
115 Mill St
Belmont MA 02478
Phone617/855-2175

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Onaivi ES, Schanz N, Lin ZC. Psychiatric disturbances regulate the innate immune system in CSF of conscious mice. Transl Psychiatry. 2014; 4:e367.
    View in: PubMed
  2. Zhai D, Li S, Zhao Y, Lin Z. SLC6A3 is a risk factor for Parkinson's disease: A meta-analysis of sixteen years' studies. Neurosci Lett. 2013 Nov 7; 564C:99-104.
    View in: PubMed
  3. Zhao Y, Xiong N, Liu Y, Zhou Y, Li N, Qing H, Lin Z. Human dopamine transporter gene: differential regulation of 18-kb haplotypes. Pharmacogenomics. 2013 Sep; 14(12):1481-94.
    View in: PubMed
  4. Won C, Lin Z, Kumar T P, Li S, Ding L, Elkhal A, Szabó G, Vasudevan A. Autonomous vascular networks synchronize GABA neuron migration in the embryonic forebrain. Nat Commun. 2013 Jul 16; 4:2149.
    View in: PubMed
  5. Zhao Y, Zhou Y, Xiong N, Lin Z. Identification of an intronic cis-acting element in the human dopamine transporter gene. Mol Biol Rep. 2012 May; 39(5):5393-9.
    View in: PubMed
  6. Zhou Y, Michelhaugh SK, Schmidt CJ, Liu JS, Bannon MJ, Lin Z. Ventral midbrain correlation between genetic variation and expression of the dopamine transporter gene in cocaine-abusing versus non-abusing subjects. Addict Biol. 2014 Jan; 19(1):122-31.
    View in: PubMed
  7. Xiong N, Xiong J, Khare G, Chen C, Huang J, Zhao Y, Zhang Z, Qiao X, Feng Y, Reesaul H, Zhang Y, Sun S, Lin Z, Wang T. Edaravone guards dopamine neurons in a rotenone model for Parkinson's disease. PLoS One. 2011; 6(6):e20677.
    View in: PubMed
  8. Xiong N, Huang J, Chen C, Zhao Y, Zhang Z, Jia M, Zhang Z, Hou L, Yang H, Cao X, Liang Z, Zhang Y, Sun S, Lin Z, Wang T. Dl-3-n-butylphthalide, a natural antioxidant, protects dopamine neurons in rotenone models for Parkinson's disease. Neurobiol Aging. 2012 Aug; 33(8):1777-91.
    View in: PubMed
  9. Lin Z, Canales JJ, Björgvinsson T, Thomsen M, Qu H, Liu QR, Torres GE, Caine SB. Monoamine transporters: vulnerable and vital doorkeepers. Prog Mol Biol Transl Sci. 2011; 98:1-46.
    View in: PubMed
  10. Xiong N, Zhang Z, Huang J, Chen C, Zhang Z, Jia M, Xiong J, Liu X, Wang F, Cao X, Liang Z, Sun S, Lin Z, Wang T. VEGF-expressing human umbilical cord mesenchymal stem cells, an improved therapy strategy for Parkinson's disease. Gene Ther. 2011 Apr; 18(4):394-402.
    View in: PubMed
  11. Xu M, Lin Z. Genetic influences of dopamine transport gene on alcohol dependence: a pooled analysis of 13 studies with 2483 cases and 1753 controls. Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jul 1; 35(5):1255-60.
    View in: PubMed
  12. Chung CY, Licznerski P, Alavian KN, Simeone A, Lin Z, Martin E, Vance J, Isacson O. The transcription factor orthodenticle homeobox 2 influences axonal projections and vulnerability of midbrain dopaminergic neurons. Brain. 2010 Jul; 133(Pt 7):2022-31.
    View in: PubMed
  13. Xiong N, Cao X, Zhang Z, Huang J, Chen C, Zhang Z, Jia M, Xiong J, Liang Z, Sun S, Lin Z, Wang T. Long-term efficacy and safety of human umbilical cord mesenchymal stromal cells in rotenone-induced hemiparkinsonian rats. Biol Blood Marrow Transplant. 2010 Nov; 16(11):1519-29.
    View in: PubMed
  14. Xu M, Xing Q, Li S, Zheng Y, Wu S, Gao R, Yu L, Guo T, Yang Y, Liu J, Zhang A, Zhao X, He G, Zhou J, Wang L, Xuan J, Du J, Li X, Feng G, Lin Z, Xu Y, St Clair D, Lin Z, He L. Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16; 34(6):1026-32.
    View in: PubMed
  15. Lin Z, Zhao Y, Chung CY, Zhou Y, Xiong N, Glatt CE, Isacson O. High regulatability favors genetic selection in SLC18A2, a vesicular monoamine transporter essential for life. FASEB J. 2010 Jul; 24(7):2191-200.
    View in: PubMed
  16. Xiong N, Huang J, Zhang Z, Zhang Z, Xiong J, Liu X, Jia M, Wang F, Chen C, Cao X, Liang Z, Sun S, Lin Z, Wang T. Stereotaxical infusion of rotenone: a reliable rodent model for Parkinson's disease. PLoS One. 2009; 4(11):e7878.
    View in: PubMed
  17. Madras BK, Xie Z, Lin Z, Jassen A, Panas H, Lynch L, Johnson R, Livni E, Spencer TJ, Bonab AA, Miller GM, Fischman AJ. Modafinil occupies dopamine and norepinephrine transporters in vivo and modulates the transporters and trace amine activity in vitro. J Pharmacol Exp Ther. 2006 Nov; 319(2):561-9.
    View in: PubMed
  18. Madras BK, Fahey MA, Goulet M, Lin Z, Bendor J, Goodrich C, Meltzer PC, Elmaleh DR, Livni E, Bonab AA, Fischman AJ. Dopamine transporter (DAT) inhibitors alleviate specific parkinsonian deficits in monkeys: association with DAT occupancy in vivo. J Pharmacol Exp Ther. 2006 Nov; 319(2):570-85.
    View in: PubMed
  19. Drgon T, Lin Z, Wang GJ, Fowler J, Pablo J, Mash DC, Volkow N, Uhl GR. Common human 5' dopamine transporter (SLC6A3) haplotypes yield varying expression levels in vivo. Cell Mol Neurobiol. 2006 Jul-Aug; 26(4-6):875-89.
    View in: PubMed
  20. Lin Z, Madras BK. Human genetics and pharmacology of neurotransmitter transporters. Handb Exp Pharmacol. 2006; (175):327-71.
    View in: PubMed
  21. Uhl GR, Ishiguro H, Onaivi ES, Zhang PW, Akinshola BE, Lin Z, Hope B, Leonard CM, Liu QR. Molecular neurobiological methods in marijuana-cannabinoid research. Methods Mol Med. 2006; 123:1-17.
    View in: PubMed
  22. Lin Z, Uhl GR. Proline mutations induce negative-dosage effects on uptake velocity of the dopamine transporter. J Neurochem. 2005 Jul; 94(1):276-87.
    View in: PubMed
  23. Lin Z, Walther D, Yu XY, Li S, Drgon T, Uhl GR. SLC18A2 promoter haplotypes and identification of a novel protective factor against alcoholism. Hum Mol Genet. 2005 May 15; 14(10):1393-404.
    View in: PubMed
  24. Lin Z, Walther D, Yu XY, Drgon T, Uhl GR. The human serotonin receptor 2B: coding region polymorphisms and association with vulnerability to illegal drug abuse. Pharmacogenetics. 2004 Dec; 14(12):805-11.
    View in: PubMed
  25. Dohi T, Kitayama S, Morioka N, Kumagai K, Mitsuhata C, Morita K, Kozai K, Lin Z, Uhl GR. Regulation of dopamine and MPP+ transport by catecholamine transporters. Nihon Shinkei Seishin Yakurigaku Zasshi. 2004 Apr; 24(2):43-7.
    View in: PubMed
  26. Liu QR, Zhang PW, Lin Z, Li QF, Woods AS, Troncoso J, Uhl GR. GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA. Biochem J. 2004 Jan 1; 377(Pt 1):171-81.
    View in: PubMed
  27. Uhl GR, Lin Z. The top 20 dopamine transporter mutants: structure-function relationships and cocaine actions. Eur J Pharmacol. 2003 Oct 31; 479(1-3):71-82.
    View in: PubMed
  28. Morón JA, Zakharova I, Ferrer JV, Merrill GA, Hope B, Lafer EM, Lin ZC, Wang JB, Javitch JA, Galli A, Shippenberg TS. Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity. J Neurosci. 2003 Sep 17; 23(24):8480-8.
    View in: PubMed
  29. Lin Z, Zhang PW, Zhu X, Melgari JM, Huff R, Spieldoch RL, Uhl GR. Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. J Biol Chem. 2003 May 30; 278(22):20162-70.
    View in: PubMed
  30. Lin Z, Uhl GR. Human dopamine transporter gene variation: effects of protein coding variants V55A and V382A on expression and uptake activities. Pharmacogenomics J. 2003; 3(3):159-68.
    View in: PubMed
  31. Itokawa M, Lin Z, Uhl GR. Dopamine efflux via wild-type and mutant dopamine transporters: alanine substitution for proline-572 enhances efflux and reduces dependence on extracellular dopamine, sodium and chloride concentrations. Brain Res Mol Brain Res. 2002 Dec; 108(1-2):71-80.
    View in: PubMed
  32. Onaivi ES, Leonard CM, Ishiguro H, Zhang PW, Lin Z, Akinshola BE, Uhl GR. Endocannabinoids and cannabinoid receptor genetics. Prog Neurobiol. 2002 Apr; 66(5):307-44.
    View in: PubMed
  33. Lin Z, Uhl GR. Dopamine transporter mutants with cocaine resistance and normal dopamine uptake provide targets for cocaine antagonism. Mol Pharmacol. 2002 Apr; 61(4):885-91.
    View in: PubMed
  34. Uhl GR, Li S, Takahashi N, Itokawa K, Lin Z, Hazama M, Sora I. The VMAT2 gene in mice and humans: amphetamine responses, locomotion, cardiac arrhythmias, aging, and vulnerability to dopaminergic toxins. FASEB J. 2000 Dec; 14(15):2459-65.
    View in: PubMed
  35. Lin Z, Wang W, Uhl GR. Dopamine transporter tryptophan mutants highlight candidate dopamine- and cocaine-selective domains. Mol Pharmacol. 2000 Dec; 58(6):1581-92.
    View in: PubMed
  36. Itokawa M, Lin Z, Cai NS, Wu C, Kitayama S, Wang JB, Uhl GR. Dopamine transporter transmembrane domain polar mutants: DeltaG and DeltaDeltaG values implicate regions important for transporter functions. Mol Pharmacol. 2000 Jun; 57(6):1093-103.
    View in: PubMed
  37. Lin Z, Itokawa M, Uhl GR. Dopamine transporter proline mutations influence dopamine uptake, cocaine analog recognition, and expression. FASEB J. 2000 Apr; 14(5):715-28.
    View in: PubMed
  38. Lin Z, Wang W, Kopajtic T, Revay RS, Uhl GR. Dopamine transporter: transmembrane phenylalanine mutations can selectively influence dopamine uptake and cocaine analog recognition. Mol Pharmacol. 1999 Aug; 56(2):434-47.
    View in: PubMed
  39. Lin Z, Mallavia LP. Functional analysis of the active partition region of the Coxiella burnetii plasmid QpH1. J Bacteriol. 1999 Mar; 181(6):1947-52.
    View in: PubMed
  40. Lin Z, Mallavia LP. Membrane association of active plasmid partitioning protein A in Escherichia coli. J Biol Chem. 1998 May 1; 273(18):11302-12.
    View in: PubMed
  41. Uhl G, Lin Z, Metzger T, Dar DE. Dopamine transporter mutants, small molecules, and approaches to cocaine antagonist/dopamine transporter disinhibitor development. Methods Enzymol. 1998; 296:456-65.
    View in: PubMed
  42. Lin Z, Yang S, Mallavia LP. Codon usage and nucleotide composition in Coxiella burnetii. Gene. 1997 Oct 1; 198(1-2):171-80.
    View in: PubMed
  43. Lin Z, Howe D, Mallavia LP. Roa307, a protein encoded on Coxiella burnetii plasmid QpH1, shows homology to proteins encoded in the replication origin region of bacterial chromosomes. Mol Gen Genet. 1995 Aug 30; 248(4):487-90.
    View in: PubMed
  44. Lin Z, Mallavia LP. The partition region of plasmid QpH1 is a member of a family of two trans-acting factors as implied by sequence analysis. Gene. 1995 Jul 4; 160(1):69-74.
    View in: PubMed
  45. Lin Z, Mallavia LP. Identification of a partition region carried by the plasmid QpH1 of Coxiella burnetii. Mol Microbiol. 1994 Aug; 13(3):513-23.
    View in: PubMed
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