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Last Name
Institution

Christopher Joseph O'Donnell, M.D.

TitleAssociate Clinical Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Cardiac Unit- Pob3
55 Fruit St
Boston MA 02114
Phone508/935-3435
Fax508/626-1262

 Mentoring 
 current student opportunities
Available: 08/16/13, Expires: 08/29/14

Dr. O’Donnell conducts his research through his role as a National Heart, Lung and Blood Institute Senior Investigator in the Framingham Heart Study, in which detailed clinical phenotyping has been completed and genomewide scans of single nucleotide polymorphisms, exome/whole genome sequencing, transcriptome profiling and RNA sequencing has been completed. In collaboration with multiple other cohorts in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium and the Exome Sequencing Program, Dr. O'Donnell directs studies of the genetic determinants of subclinical atherosclerosis, clinical coronary heart disease, thrombosis and hemostasis and coronary heart disease risk factors. As such, he has been director and principal investigator of a large study of multidetector computed tomography imaging in two generations of family members to study coronary and aortic atherosclerosis. He is the FHS co-principal investigator on similar studies of cardiac magnetic resonance imaging and carotid ultrasound imaging in the Framingham Offspring. He is the principal investigator of detailed genetic studies of coronary and aortic calcification, carotid artery intimal medial thickness, hemostatic factor levels, and of aortic and left ventricular structure and function. He has overseen a study of the genetics of premature acute coronary syndromes at the Massachusetts General Hospital (MGH), one of the founding cohorts for the Myocardial Infarction Genetics (MIGen) Consortium and the Early MI project of the Exome Sequencing Project. A number of student projects are possible using data from these various projects and programs.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ganesh SK, Arnett DK, Assimes TL, Basson CT, Chakravarti A, Ellinor PT, Engler MB, Goldmuntz E, Herrington DM, Hershberger RE, Hong Y, Johnson JA, Kittner SJ, McDermott DA, Meschia JF, Mestroni L, O'Donnell CJ, Psaty BM, Vasan RS, Ruel M, Shen WK, Terzic A, Waldman SA. Genetics and genomics for the prevention and treatment of cardiovascular disease: update: a scientific statement from the american heart association. Circulation. 2013 Dec 24; 128(25):2813-51.
    View in: PubMed
  2. Hruby A, O'Donnell CJ, Jacques PF, Meigs JB, Hoffmann U, McKeown NM. Magnesium intake is inversely associated with coronary artery calcification: the framingham heart study. JACC Cardiovasc Imaging. 2014 Jan; 7(1):59-69.
    View in: PubMed
  3. Hong SN, Gona P, Fontes JD, Oyama N, Chan RH, Kenchaiah S, Tsao CW, Yeon SB, Schnabel RB, Keaney JF, O'Donnell CJ, Benjamin EJ, Manning WJ. Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the framingham heart study. J Am Heart Assoc. 2013; 2(6):e000307.
    View in: PubMed
  4. Chuang ML, Leslie RW, Massaro JM, Manders ES, Fox CS, Hoffmann U, O'Donnell CJ. Distribution of abdominal aortic calcium by computed tomography: impact of analysis method on quantitative calcium score. Acad Radiol. 2013 Nov; 20(11):1422-8.
    View in: PubMed
  5. Flannick J, Beer NL, Bick AG, Agarwala V, Molnes J, Gupta N, Burtt NP, Florez JC, Meigs JB, Taylor H, Lyssenko V, Irgens H, Fox E, Burslem F, Johansson S, Brosnan MJ, Trimmer JK, Newton-Cheh C, Tuomi T, Molven A, Wilson JG, O'Donnell CJ, Kathiresan S, Hirschhorn JN, Njølstad PR, Rolph T, Seidman JG, Gabriel S, Cox DR, Seidman CE, Groop L, Altshuler D. Assessing the phenotypic effects in the general population of rare variants in genes for a dominant Mendelian form of diabetes. Nat Genet. 2013 Nov; 45(11):1380-5.
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  6. Roseman DA, Hwang SJ, Manders ES, O'Donnell CJ, Upadhyay A, Hoffmann U, Fox CS. Renal artery calcium, cardiovascular risk factors, and indexes of renal function. Am J Cardiol. 2014 Jan 1; 113(1):156-61.
    View in: PubMed
  7. Hruby A, Meigs JB, O'Donnell CJ, Jacques PF, McKeown NM. Higher magnesium intake reduces risk of impaired glucose and insulin metabolism and progression from prediabetes to diabetes in middle-aged americans. Diabetes Care. 2014 Feb; 37(2):419-27.
    View in: PubMed
  8. Zhang X, Johnson AD, Hendricks AE, Hwang SJ, Tanriverdi K, Ganesh SK, Smith NL, Peyser PA, Freedman JE, O'Donnell CJ. Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. Hum Mol Genet. 2014 Feb 1; 23(3):782-95.
    View in: PubMed
  9. Wang TJ, Ngo D, Psychogios N, Dejam A, Larson MG, Vasan RS, Ghorbani A, O'Sullivan J, Cheng S, Rhee EP, Sinha S, McCabe E, Fox CS, O'Donnell CJ, Ho JE, Florez JC, Magnusson M, Pierce KA, Souza AL, Yu Y, Carter C, Light PE, Melander O, Clish CB, Gerszten RE. 2-Aminoadipic acid is a biomarker for diabetes risk. J Clin Invest. 2013 Oct 1; 123(10):4309-17.
    View in: PubMed
  10. Ho JE, Chen WY, Chen MH, Larson MG, McCabe EL, Cheng S, Ghorbani A, Coglianese E, Emilsson V, Johnson AD, Walter S, Franceschini N, O'Donnell CJ, Dehghan A, Lu C, Levy D, Newton-Cheh C, Lin H, Felix JF, Schreiter ER, Vasan RS, Januzzi JL, Lee RT, Wang TJ. Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling. J Clin Invest. 2013 Oct 1; 123(10):4208-18.
    View in: PubMed
  11. Rosenquist KJ, Massaro JM, Pencina KM, D'Agostino RB, Beiser A, O'Connor GT, O'Donnell CJ, Wolf PA, Polak JF, Seshadri S, Fox CS. Neck circumference, carotid wall intima-media thickness, and incident stroke. Diabetes Care. 2013 Sep; 36(9):e153-4.
    View in: PubMed
  12. Thanassoulis G, Peloso GM, O'Donnell CJ. Genomic medicine for improved prediction and primordial prevention of cardiovascular disease. Arterioscler Thromb Vasc Biol. 2013 Sep; 33(9):2049-50.
    View in: PubMed
  13. Sabater-Lleal M, Huang J, Chasman D, Naitza S, Dehghan A, Johnson AD, Teumer A, Reiner AP, Folkersen L, Basu S, Rudnicka AR, Trompet S, Mälarstig A, Baumert J, Bis JC, Guo X, Hottenga JJ, Shin SY, Lopez LM, Lahti J, Tanaka T, Yanek LR, Oudot-Mellakh T, Wilson JF, Navarro P, Huffman JE, Zemunik T, Redline S, Mehra R, Pulanic D, Rudan I, Wright AF, Kolcic I, Polasek O, Wild SH, Campbell H, Curb JD, Wallace R, Liu S, Eaton CB, Becker DM, Becker LC, Bandinelli S, Räikkönen K, Widen E, Palotie A, Fornage M, Green D, Gross M, Davies G, Harris SE, Liewald DC, Starr JM, Williams FM, Grant PJ, Spector TD, Strawbridge RJ, Silveira A, Sennblad B, Rivadeneira F, Uitterlinden AG, Franco OH, Hofman A, van Dongen J, Willemsen G, Boomsma DI, Yao J, Swords Jenny N, Haritunians T, McKnight B, Lumley T, Taylor KD, Rotter JI, Psaty BM, Peters A, Gieger C, Illig T, Grotevendt A, Homuth G, Völzke H, Kocher T, Goel A, Franzosi MG, Seedorf U, Clarke R, Steri M, Tarasov KV, Sanna S, Schlessinger D, Stott DJ, Sattar N, Buckley BM, Rumley A, Lowe GD, McArdle WL, Chen MH, Tofler GH, Song J, Boerwinkle E, Folsom AR, Rose LM, Franco-Cereceda A, Teichert M, Ikram MA, Mosley TH, Bevan S, Dichgans M, Rothwell PM, Sudlow CL, Hopewell JC, Chambers JC, Saleheen D, Kooner JS, Danesh J, Nelson CP, Erdmann J, Reilly MP, Kathiresan S, Schunkert H, Morange PE, Ferrucci L, Eriksson JG, Jacobs D, Deary IJ, Soranzo N, Witteman JC, de Geus EJ, Tracy RP, Hayward C, Koenig W, Cucca F, Jukema JW, Eriksson P, Seshadri S, Markus HS, Watkins H, Samani NJ, Wallaschofski H, Smith NL, Tregouet D, Ridker PM, Tang W, Strachan DP, Hamsten A, O'Donnell CJ. Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease. Circulation. 2013 Sep 17; 128(12):1310-24.
    View in: PubMed
  14. Wojczynski MK, Li M, Bielak LF, Kerr KF, Reiner AP, Wong ND, Yanek LR, Qu L, White CC, Lange LA, Ferguson JF, He J, Young T, Mosley TH, Smith JA, Kral BG, Guo X, Wong Q, Ganesh SK, Heckbert SR, Griswold ME, O'Leary DH, Budoff M, Carr JJ, Taylor HA, Bluemke DA, Demissie S, Hwang SJ, Paltoo DN, Polak JF, Psaty BM, Becker DM, Province MA, Post WS, O'Donnell CJ, Wilson JG, Harris TB, Kavousi M, Cupples LA, Rotter JI, Fornage M, Becker LC, Peyser PA, Borecki IB, Reilly MP. Genetics of coronary artery calcification among African Americans, a meta-analysis. BMC Med Genet. 2013; 14:75.
    View in: PubMed
  15. Grove ML, Yu B, Cochran BJ, Haritunians T, Bis JC, Taylor KD, Hansen M, Borecki IB, Cupples LA, Fornage M, Gudnason V, Harris TB, Kathiresan S, Kraaij R, Launer LJ, Levy D, Liu Y, Mosley T, Peloso GM, Psaty BM, Rich SS, Rivadeneira F, Siscovick DS, Smith AV, Uitterlinden A, van Duijn CM, Wilson JG, O'Donnell CJ, Rotter JI, Boerwinkle E. Best Practices and Joint Calling of the HumanExome BeadChip: The CHARGE Consortium. PLoS One. 2013; 8(7):e68095.
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  16. van Meurs JB, Pare G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH, Cotlarciuc I, Yuan X, Mälarstig A, Bandinelli S, Bis JC, Blom H, Brown MJ, Chen C, Chen YD, Clarke RJ, Dehghan A, Erdmann J, Ferrucci L, Hamsten A, Hofman A, Hunter DJ, Goel A, Johnson AD, Kathiresan S, Kampman E, Kiel DP, Kiemeney LA, Chambers JC, Kraft P, Lindemans J, McKnight B, Nelson CP, O'Donnell CJ, Psaty BM, Ridker PM, Rivadeneira F, Rose LM, Seedorf U, Siscovick DS, Schunkert H, Selhub J, Ueland PM, Vollenweider P, Waeber G, Waterworth DM, Watkins H, Witteman JC, den Heijer M, Jacques P, Uitterlinden AG, Kooner JS, Rader DJ, Reilly MP, Mooser V, Chasman DI, Samani NJ, Ahmadi KR. Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. Am J Clin Nutr. 2013 Sep; 98(3):668-76.
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  17. Rhee EP, Ho JE, Chen MH, Shen D, Cheng S, Larson MG, Ghorbani A, Shi X, Helenius IT, O'Donnell CJ, Souza AL, Deik A, Pierce KA, Bullock K, Walford GA, Vasan RS, Florez JC, Clish C, Yeh JR, Wang TJ, Gerszten RE. A Genome-wide Association Study of the Human Metabolome in a Community-Based Cohort. Cell Metab. 2013 Jul 2; 18(1):130-43.
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  18. Morrison AC, Voorman A, Johnson AD, Liu X, Yu J, Li A, Muzny D, Yu F, Rice K, Zhu C, Bis J, Heiss G, O'Donnell CJ, Psaty BM, Cupples LA, Gibbs R, Boerwinkle E. Whole-genome sequence-based analysis of high-density lipoprotein cholesterol. Nat Genet. 2013 Aug; 45(8):899-901.
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  19. Li A, Ahsen OO, Liu JJ, Du C, McKee ML, Yang Y, Wasco W, Newton-Cheh CH, O'Donnell CJ, Fujimoto JG, Zhou C, Tanzi RE. Silencing of the Drosophila ortholog of SOX5 in heart leads to cardiac dysfunction as detected by optical coherence tomography. Hum Mol Genet. 2013 Sep 15; 22(18):3798-806.
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  20. Ge Y, Cheng S, Larson MG, Ghorbani A, Martin RP, Klein RJ, O'Donnell CJ, Vasan RS, Shaw SY, Wang TJ, Cohen KS. Circulating CD31+ leukocyte frequency is associated with cardiovascular risk factors. Atherosclerosis. 2013 Jul; 229(1):228-33.
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  21. Lim S, Hong J, Liu CT, Hivert MF, White CC, Murabito JM, O'Donnell CJ, Dupuis J, Florez JC, Meigs JB. Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study. Atherosclerosis. 2013 Jul; 229(1):149-54.
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  22. den Hoed M, Eijgelsheim M, Esko T, Brundel BJ, Peal DS, Evans DM, Nolte IM, Segrè AV, Holm H, Handsaker RE, Westra HJ, Johnson T, Isaacs A, Yang J, Lundby A, Zhao JH, Kim YJ, Go MJ, Almgren P, Bochud M, Boucher G, Cornelis MC, Gudbjartsson D, Hadley D, van der Harst P, Hayward C, den Heijer M, Igl W, Jackson AU, Kutalik Z, Luan J, Kemp JP, Kristiansson K, Ladenvall C, Lorentzon M, Montasser ME, Njajou OT, O'Reilly PF, Padmanabhan S, St Pourcain B, Rankinen T, Salo P, Tanaka T, Timpson NJ, Vitart V, Waite L, Wheeler W, Zhang W, Draisma HH, Feitosa MF, Kerr KF, Lind PA, Mihailov E, Onland-Moret NC, Song C, Weedon MN, Xie W, Yengo L, Absher D, Albert CM, Alonso A, Arking DE, de Bakker PI, Balkau B, Barlassina C, Benaglio P, Bis JC, Bouatia-Naji N, Brage S, Chanock SJ, Chines PS, Chung M, Darbar D, Dina C, Dörr M, Elliott P, Felix SB, Fischer K, Fuchsberger C, de Geus EJ, Goyette P, Gudnason V, Harris TB, Hartikainen AL, Havulinna AS, Heckbert SR, Hicks AA, Hofman A, Holewijn S, Hoogstra-Berends F, Hottenga JJ, Jensen MK, Johansson A, Junttila J, Kääb S, Kanon B, Ketkar S, Khaw KT, Knowles JW, Kooner AS, Kors JA, Kumari M, Milani L, Laiho P, Lakatta EG, Langenberg C, Leusink M, Liu Y, Luben RN, Lunetta KL, Lynch SN, Markus MR, Marques-Vidal P, Mateo Leach I, McArdle WL, McCarroll SA, Medland SE, Miller KA, Montgomery GW, Morrison AC, Müller-Nurasyid M, Navarro P, Nelis M, O'Connell JR, O'Donnell CJ, Ong KK, Newman AB, Peters A, Polasek O, Pouta A, Pramstaller PP, Psaty BM, Rao DC, Ring SM, Rossin EJ, Rudan D, Sanna S, Scott RA, Sehmi JS, Sharp S, Shin JT, Singleton AB, Smith AV, Soranzo N, Spector TD, Stewart C, Stringham HM, Tarasov KV, Uitterlinden AG, Vandenput L, Hwang SJ, Whitfield JB, Wijmenga C, Wild SH, Willemsen G, Wilson JF, Witteman JC, Wong A, Wong Q, Jamshidi Y, Zitting P, Boer JM, Boomsma DI, Borecki IB, van Duijn CM, Ekelund U, Forouhi NG, Froguel P, Hingorani A, Ingelsson E, Kivimaki M, Kronmal RA, Kuh D, Lind L, Martin NG, Oostra BA, Pedersen NL, Quertermous T, Rotter JI, van der Schouw YT, Verschuren WM, Walker M, Albanes D, Arnar DO, Assimes TL, Bandinelli S, Boehnke M, de Boer RA, Bouchard C, Caulfield WL, Chambers JC, Curhan G, Cusi D, Eriksson J, Ferrucci L, van Gilst WH, Glorioso N, de Graaf J, Groop L, Gyllensten U, Hsueh WC, Hu FB, Huikuri HV, Hunter DJ, Iribarren C, Isomaa B, Jarvelin MR, Jula A, Kähönen M, Kiemeney LA, van der Klauw MM, Kooner JS, Kraft P, Iacoviello L, Lehtimäki T, Lokki ML, Mitchell BD, Navis G, Nieminen MS, Ohlsson C, Poulter NR, Qi L, Raitakari OT, Rimm EB, Rioux JD, Rizzi F, Rudan I, Salomaa V, Sever PS, Shields DC, Shuldiner AR, Sinisalo J, Stanton AV, Stolk RP, Strachan DP, Tardif JC, Thorsteinsdottir U, Tuomilehto J, van Veldhuisen DJ, Virtamo J, Viikari J, Vollenweider P, Waeber G, Widen E, Cho YS, Olsen JV, Visscher PM, Willer C, Franke L, Erdmann J, Thompson JR, Pfeufer A, Sotoodehnia N, Newton-Cheh C, Ellinor PT, Stricker BH, Metspalu A, Perola M, Beckmann JS, Smith GD, Stefansson K, Wareham NJ, Munroe PB, Sibon OC, Milan DJ, Snieder H, Samani NJ, Loos RJ. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nat Genet. 2013 Apr 14; 45(6):621-31.
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  23. Joehanes R, Ying S, Huan T, Johnson AD, Raghavachari N, Wang R, Liu P, Woodhouse KA, Sen SK, Tanriverdi K, Courchesne P, Freedman JE, O'Donnell CJ, Levy D, Munson PJ. Gene expression signatures of coronary heart disease. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1418-26.
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  24. Huan T, Zhang B, Wang Z, Joehanes R, Zhu J, Johnson AD, Ying S, Munson PJ, Raghavachari N, Wang R, Liu P, Courchesne P, Hwang SJ, Assimes TL, McPherson R, Samani NJ, Schunkert H, Meng Q, Suver C, O'Donnell CJ, Derry J, Yang X, Levy D. A systems biology framework identifies molecular underpinnings of coronary heart disease. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1427-34.
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  25. Rogers IS, Massaro JM, Truong QA, Mahabadi AA, Kriegel MF, Fox CS, Thanassoulis G, Isselbacher EM, Hoffmann U, O'Donnell CJ. Distribution, Determinants, and Normal Reference Values of Thoracic and Abdominal Aortic Diameters by Computed Tomography (from the Framingham Heart Study). Am J Cardiol. 2013 May 15; 111(10):1510-6.
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  26. Olden M, Teumer A, Bochud M, Pattaro C, Köttgen A, Turner ST, Rettig R, Chen MH, Dehghan A, Bastardot F, Schmidt R, Vollenweider P, Schunkert H, Reilly MP, Fornage M, Launer LJ, Verwoert GC, Mitchell GF, Bis JC, O'Donnell CJ, Cheng CY, Sim X, Siscovick DS, Coresh J, Kao WH, Fox CS, O'Seaghdha CM. Overlap Between Common Genetic Polymorphisms Underpinning Kidney Traits and Cardiovascular Disease Phenotypes: The CKDGen Consortium. Am J Kidney Dis. 2013 Jun; 61(6):889-98.
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  27. Tsao CW, O'Donnell CJ. Lipid profiles and coronary artery plaque by CT angiography: Promise for translation of biology to imaging. J Cardiovasc Comput Tomogr. 2013 Mar-Apr; 7(2):91-3.
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  28. Thanassoulis G, Campbell CY, Owens DS, Smith JG, Smith AV, Peloso GM, Kerr KF, Pechlivanis S, Budoff MJ, Harris TB, Malhotra R, O'Brien KD, Kamstrup PR, Nordestgaard BG, Tybjaerg-Hansen A, Allison MA, Aspelund T, Criqui MH, Heckbert SR, Hwang SJ, Liu Y, Sjogren M, van der Pals J, Kälsch H, Mühleisen TW, Nöthen MM, Cupples LA, Caslake M, Di Angelantonio E, Danesh J, Rotter JI, Sigurdsson S, Wong Q, Erbel R, Kathiresan S, Melander O, Gudnason V, O'Donnell CJ, Post WS. Genetic associations with valvular calcification and aortic stenosis. N Engl J Med. 2013 Feb 7; 368(6):503-12.
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  29. Jensen RA, Sim X, Li X, Cotch MF, Ikram MK, Holliday EG, Eiriksdottir G, Harris TB, Jonasson F, Klein BE, Launer LJ, Smith AV, Boerwinkle E, Cheung N, Hewitt AW, Liew G, Mitchell P, Wang JJ, Attia J, Scott R, Glazer NL, Lumley T, McKnight B, Psaty BM, Taylor K, Hofman A, de Jong PT, Rivadeneira F, Uitterlinden AG, Tay WT, Teo YY, Seielstad M, Liu J, Cheng CY, Saw SM, Aung T, Ganesh SK, O'Donnell CJ, Nalls MA, Wiggins KL, Kuo JZ, van Duijn CM, Gudnason V, Klein R, Siscovick DS, Rotter JI, Tai ES, Vingerling J, Wong TY. Genome-Wide Association Study of Retinopathy in Individuals without Diabetes. PLoS One. 2013; 8(2):e54232.
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  30. Crosslin DR, McDavid A, Weston N, Zheng X, Hart E, de Andrade M, Kullo IJ, McCarty CA, Doheny KF, Pugh E, Kho A, Hayes MG, Ritchie MD, Saip A, Crawford DC, Crane PK, Newton K, Carrell DS, Gallego CJ, Nalls MA, Li R, Mirel DB, Crenshaw A, Couper DJ, Tanaka T, van Rooij FJ, Chen MH, Smith AV, Zakai NA, Yango Q, Garcia M, Liu Y, Lumley T, Folsom AR, Reiner AP, Felix JF, Dehghan A, Wilson JG, Bis JC, Fox CS, Glazer NL, Cupples LA, Coresh J, Eiriksdottir G, Gudnason V, Bandinelli S, Frayling TM, Chakravarti A, van Duijn CM, Melzer D, Levy D, Boerwinkle E, Singleton AB, Hernandez DG, Longo DL, Witteman JC, Psaty BM, Ferrucci L, Harris TB, O'Donnell CJ, Ganesh SK, Larson EB, Carlson CS, Jarvik GP. Genetic variation associated with circulating monocyte count in the eMERGE Network. Hum Mol Genet. 2013 May 15; 22(10):2119-27.
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  31. Johnson AD, Hwang SJ, Voorman A, Morrison A, Peloso GM, Hsu YH, Thanassoulis G, Newton-Cheh C, Rogers IS, Hoffmann U, Freedman JE, Fox CS, Psaty BM, Boerwinkle E, Cupples LA, O'Donnell CJ. Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the framingham heart study. Circulation. 2013 Feb 19; 127(7):799-810.
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  32. Cohen KS, Cheng S, Larson MG, Cupples LA, McCabe EL, Wang YA, Ngwa JS, Martin RP, Klein RJ, Hashmi B, Ge Y, O'Donnell CJ, Vasan RS, Shaw SY, Wang TJ. Circulating CD34+ progenitor cell frequency is associated with clinical and genetic factors. Blood. 2013 Feb 21; 121(8):e50-6.
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  33. Johnson A, Archer M, Leigh-Shaw L, Brown M, O'Donnell C, Wallman J. Non-invasive visualisation and volume estimation of maggot masses using computed tomography scanning. Int J Legal Med. 2013 Jan; 127(1):185-94.
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  34. Thanassoulis G, Massaro JM, Corsini E, Rogers I, Schlett CL, Meigs JB, Hoffmann U, O'Donnell CJ, Fox CS. Periaortic adipose tissue and aortic dimensions in the framingham heart study. J Am Heart Assoc. 2012 Dec; 1(6):e000885.
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  35. Chen MH, Huang J, Chen WM, Larson MG, Fox CS, Vasan RS, Seshadri S, O'Donnell CJ, Yang Q. Using family-based imputation in genome-wide association studies with large complex pedigrees: the framingham heart study. PLoS One. 2012; 7(12):e51589.
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  36. Yu B, Barbalic M, Brautbar A, Nambi V, Hoogeveen RC, Tang W, Mosley TH, Rotter JI, Defilippi CR, O'Donnell CJ, Kathiresan S, Rice K, Heckbert SR, Ballantyne CM, Psaty BM, Boerwinkle E. Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European americans and blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. Circ Cardiovasc Genet. 2013 Feb 1; 6(1):82-8.
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  37. Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, Goldstein BA, Stirrups K, König IR, Cazier JB, Johansson A, Hall AS, Lee JY, Willer CJ, Chambers JC, Esko T, Folkersen L, Goel A, Grundberg E, Havulinna AS, Ho WK, Hopewell JC, Eriksson N, Kleber ME, Kristiansson K, Lundmark P, Lyytikäinen LP, Rafelt S, Shungin D, Strawbridge RJ, Thorleifsson G, Tikkanen E, Van Zuydam N, Voight BF, Waite LL, Zhang W, Ziegler A, Absher D, Altshuler D, Balmforth AJ, Barroso I, Braund PS, Burgdorf C, Claudi-Boehm S, Cox D, Dimitriou M, Do R, Doney AS, El Mokhtari N, Eriksson P, Fischer K, Fontanillas P, Franco-Cereceda A, Gigante B, Groop L, Gustafsson S, Hager J, Hallmans G, Han BG, Hunt SE, Kang HM, Illig T, Kessler T, Knowles JW, Kolovou G, Kuusisto J, Langenberg C, Langford C, Leander K, Lokki ML, Lundmark A, McCarthy MI, Meisinger C, Melander O, Mihailov E, Maouche S, Morris AD, Müller-Nurasyid M, Nikus K, Peden JF, Rayner NW, Rasheed A, Rosinger S, Rubin D, Rumpf MP, Schäfer A, Sivananthan M, Song C, Stewart AF, Tan ST, Thorgeirsson G, van der Schoot CE, Wagner PJ, Wells GA, Wild PS, Yang TP, Amouyel P, Arveiler D, Basart H, Boehnke M, Boerwinkle E, Brambilla P, Cambien F, Cupples AL, de Faire U, Dehghan A, Diemert P, Epstein SE, Evans A, Ferrario MM, Ferrières J, Gauguier D, Go AS, Goodall AH, Gudnason V, Hazen SL, Holm H, Iribarren C, Jang Y, Kähönen M, Kee F, Kim HS, Klopp N, Koenig W, Kratzer W, Kuulasmaa K, Laakso M, Laaksonen R, Lee JY, Lind L, Ouwehand WH, Parish S, Park JE, Pedersen NL, Peters A, Quertermous T, Rader DJ, Salomaa V, Schadt E, Shah SH, Sinisalo J, Stark K, Stefansson K, Trégouët DA, Virtamo J, Wallentin L, Wareham N, Zimmermann ME, Nieminen MS, Hengstenberg C, Sandhu MS, Pastinen T, Syvänen AC, Hovingh GK, Dedoussis G, Franks PW, Lehtimäki T, Metspalu A, Zalloua PA, Siegbahn A, Schreiber S, Ripatti S, Blankenberg SS, Perola M, Clarke R, Boehm BO, O'Donnell C, Reilly MP, März W, Collins R, Kathiresan S, Hamsten A, Kooner JS, Thorsteinsdottir U, Danesh J, Palmer CN, Roberts R, Watkins H, Schunkert H, Samani NJ. Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 2013 Jan; 45(1):25-33.
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  126. Upadhyay A, Larson MG, Guo CY, Vasan RS, Lipinska I, O'Donnell CJ, Kathiresan S, Meigs JB, Keaney JF, Rong J, Benjamin EJ, Fox CS. Inflammation, kidney function and albuminuria in the Framingham Offspring cohort. Nephrol Dial Transplant. 2011 Mar; 26(3):920-6.
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  128. Debette S, Beiser A, Hoffmann U, Decarli C, O'Donnell CJ, Massaro JM, Au R, Himali JJ, Wolf PA, Fox CS, Seshadri S. Visceral fat is associated with lower brain volume in healthy middle-aged adults. Ann Neurol. 2010 Aug; 68(2):136-44.
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  129. Johansen CT, Wang J, Lanktree MB, Cao H, McIntyre AD, Ban MR, Martins RA, Kennedy BA, Hassell RG, Visser ME, Schwartz SM, Voight BF, Elosua R, Salomaa V, O'Donnell CJ, Dallinga-Thie GM, Anand SS, Yusuf S, Huff MW, Kathiresan S, Hegele RA. Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia. Nat Genet. 2010 Aug; 42(8):684-7.
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  131. Fox CS, Massaro JM, Schlett CL, Lehman SJ, Meigs JB, O'Donnell CJ, Hoffmann U, Murabito JM. Periaortic fat deposition is associated with peripheral arterial disease: the Framingham heart study. Circ Cardiovasc Imaging. 2010 Sep; 3(5):515-9.
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  132. Olivotto I, Maron BJ, Appelbaum E, Harrigan CJ, Salton C, Gibson CM, Udelson JE, O'Donnell C, Lesser JR, Manning WJ, Maron MS. Spectrum and clinical significance of systolic function and myocardial fibrosis assessed by cardiovascular magnetic resonance in hypertrophic cardiomyopathy. Am J Cardiol. 2010 Jul 15; 106(2):261-7.
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  133. Freedman JE, Larson MG, Tanriverdi K, O'Donnell CJ, Morin K, Hakanson AS, Vasan RS, Johnson AD, Iafrati MD, Benjamin EJ. Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study. Circulation. 2010 Jul 13; 122(2):119-29.
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  134. Iino M, O'Donnell C. Postmortem computed tomography findings of upper airway obstruction by food. J Forensic Sci. 2010 Sep; 55(5):1251-8.
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  136. Johnson AD, Yanek LR, Chen MH, Faraday N, Larson MG, Tofler G, Lin SJ, Kraja AT, Province MA, Yang Q, Becker DM, O'Donnell CJ, Becker LC. Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet. 2010 Jul; 42(7):608-13.
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  138. Johnson AD, Bhimavarapu A, Benjamin EJ, Fox C, Levy D, Jarvik GP, O'Donnell CJ. CLIA-tested genetic variants on commercial SNP arrays: potential for incidental findings in genome-wide association studies. Genet Med. 2010 Jun; 12(6):355-63.
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  140. Thanassoulis G, Massaro JM, Cury R, Manders E, Benjamin EJ, Vasan RS, Cupple LA, Hoffmann U, O'Donnell CJ, Kathiresan S. Associations of long-term and early adult atherosclerosis risk factors with aortic and mitral valve calcium. J Am Coll Cardiol. 2010 Jun 1; 55(22):2491-8.
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  144. Levy D, Splansky GL, Strand NK, Atwood LD, Benjamin EJ, Blease S, Cupples LA, D'Agostino RB, Fox CS, Kelly-Hayes M, Koski G, Larson MG, Mutalik KM, Oberacker E, O'Donnell CJ, Sutherland P, Valentino M, Vasan RS, Wolf PA, Murabito JM. Consent for genetic research in the Framingham Heart Study. Am J Med Genet A. 2010 May; 152A(5):1250-6.
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  146. Lovely RS, Kazmierczak SC, Massaro JM, D'Agostino RB, O'Donnell CJ, Farrell DH. Gamma' fibrinogen: evaluation of a new assay for study of associations with cardiovascular disease. Clin Chem. 2010 May; 56(5):781-8.
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  147. Preis SR, Massaro JM, Robins SJ, Hoffmann U, Vasan RS, Irlbeck T, Meigs JB, Sutherland P, D'Agostino RB, O'Donnell CJ, Fox CS. Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study. Obesity (Silver Spring). 2010 Nov; 18(11):2191-8.
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  148. Smith NL, Chen MH, Dehghan A, Strachan DP, Basu S, Soranzo N, Hayward C, Rudan I, Sabater-Lleal M, Bis JC, de Maat MP, Rumley A, Kong X, Yang Q, Williams FM, Vitart V, Campbell H, Mälarstig A, Wiggins KL, Van Duijn CM, McArdle WL, Pankow JS, Johnson AD, Silveira A, McKnight B, Uitterlinden AG, Aleksic N, Meigs JB, Peters A, Koenig W, Cushman M, Kathiresan S, Rotter JI, Bovill EG, Hofman A, Boerwinkle E, Tofler GH, Peden JF, Psaty BM, Leebeek F, Folsom AR, Larson MG, Spector TD, Wright AF, Wilson JF, Hamsten A, Lumley T, Witteman JC, Tang W, O'Donnell CJ. Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. Circulation. 2010 Mar 30; 121(12):1382-92.
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  149. Velagaleti RS, Gona P, Chuang ML, Salton CJ, Fox CS, Blease SJ, Yeon SB, Manning WJ, O'Donnell CJ. Relations of insulin resistance and glycemic abnormalities to cardiovascular magnetic resonance measures of cardiac structure and function: the Framingham Heart Study. Circ Cardiovasc Imaging. 2010 May; 3(3):257-63.
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  150. Schlett CL, Kwait DC, Mahabadi AA, Bamberg F, O'Donnell CJ, Fox CS, Hoffmann U. Simple area-based measurement for multidetector computed tomography to predict left ventricular size. Eur Radiol. 2010 Jul; 20(7):1590-6.
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  155. Tadros TM, Massaro JM, Rosito GA, Hoffmann U, Vasan RS, Larson MG, Keaney JF, Lipinska I, Meigs JB, Kathiresan S, O'Donnell CJ, Fox CS, Benjamin EJ. Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study. Obesity (Silver Spring). 2010 May; 18(5):1039-45.
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  156. Cheng S, Massaro JM, Fox CS, Larson MG, Keyes MJ, McCabe EL, Robins SJ, O'Donnell CJ, Hoffmann U, Jacques PF, Booth SL, Vasan RS, Wolf M, Wang TJ. Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study. Diabetes. 2010 Jan; 59(1):242-8.
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  171. Dehghan A, Yang Q, Peters A, Basu S, Bis JC, Rudnicka AR, Kavousi M, Chen MH, Baumert J, Lowe GD, McKnight B, Tang W, de Maat M, Larson MG, Eyhermendy S, McArdle WL, Lumley T, Pankow JS, Hofman A, Massaro JM, Rivadeneira F, Kolz M, Taylor KD, van Duijn CM, Kathiresan S, Illig T, Aulchenko YS, Volcik KA, Johnson AD, Uitterlinden AG, Tofler GH, Gieger C, Psaty BM, Couper DJ, Boerwinkle E, Koenig W, O'Donnell CJ, Witteman JC, Strachan DP, Smith NL, Folsom AR. Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circ Cardiovasc Genet. 2009 Apr; 2(2):125-33.
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  173. Lin JP, Schwaiger JP, Cupples LA, O'Donnell CJ, Zheng G, Schoenborn V, Hunt SC, Joo J, Kronenberg F. Conditional linkage and genome-wide association studies identify UGT1A1 as a major gene for anti-atherogenic serum bilirubin levels--the Framingham Heart Study. Atherosclerosis. 2009 Sep; 206(1):228-33.
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  174. Fox CS, Gona P, Hoffmann U, Porter SA, Salton CJ, Massaro JM, Levy D, Larson MG, D'Agostino RB, O'Donnell CJ, Manning WJ. Pericardial fat, intrathoracic fat, and measures of left ventricular structure and function: the Framingham Heart Study. Circulation. 2009 Mar 31; 119(12):1586-91.
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  175. Parikh NI, Keyes MJ, Larson MG, Pou KM, Hamburg NM, Vita JA, O'Donnell CJ, Vasan RS, Mitchell GF, Hoffmann U, Fox CS, Benjamin EJ. Visceral and subcutaneous adiposity and brachial artery vasodilator function. Obesity (Silver Spring). 2009 Nov; 17(11):2054-9.
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  176. Parikh NI, Gona P, Larson MG, Fox CS, Benjamin EJ, Murabito JM, O'Donnell CJ, Vasan RS, Levy D. Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study. Circulation. 2009 Mar 10; 119(9):1203-10.
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  177. Jain SH, Massaro JM, Hoffmann U, Rosito GA, Vasan RS, Raji A, O'Donnell CJ, Meigs JB, Fox CS. Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study. Diabetes Care. 2009 May; 32(5):903-8.
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  180. Psaty BM, O'Donnell CJ, Gudnason V, Lunetta KL, Folsom AR, Rotter JI, Uitterlinden AG, Harris TB, Witteman JC, Boerwinkle E. Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium: Design of prospective meta-analyses of genome-wide association studies from 5 cohorts. Circ Cardiovasc Genet. 2009 Feb; 2(1):73-80.
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  181. Crosier MD, Booth SL, Peter I, Dawson-Hughes B, Price PA, O'Donnell CJ, Hoffmann U, Williamson MK, Ordovas JM. Matrix Gla protein polymorphisms are associated with coronary artery calcification in men. J Nutr Sci Vitaminol (Tokyo). 2009 Feb; 55(1):59-65.
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  182. Lin JP, O'Donnell CJ, Fox CS, Cupples LA. Heritability of serum gamma-glutamyltransferase level: genetic analysis from the Framingham Offspring Study. Liver Int. 2009 May; 29(5):776-7.
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  183. Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K, Haase N, Hailpern S, Ho M, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott M, Meigs J, Mozaffarian D, Nichol G, O'Donnell C, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Steinberger J, Thom T, Wasserthiel-Smoller S, Wong N, Wylie-Rosett J, Hong Y. Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009 Jan 27; 119(3):480-6.
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  184. Lieb W, Manning AK, Florez JC, Dupuis J, Cupples LA, McAteer JB, Vasan RS, Hoffmann U, O'Donnell CJ, Meigs JB, Fox CS. Variants in the CNR1 and the FAAH genes and adiposity traits in the community. Obesity (Silver Spring). 2009 Apr; 17(4):755-60.
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  185. Johnson AD, O'Donnell CJ. An open access database of genome-wide association results. BMC Med Genet. 2009; 10:6.
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  186. Mahabadi AA, Massaro JM, Rosito GA, Levy D, Murabito JM, Wolf PA, O'Donnell CJ, Fox CS, Hoffmann U. Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study. Eur Heart J. 2009 Apr; 30(7):850-6.
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  188. Molenaar EA, Massaro JM, Jacques PF, Pou KM, Ellison RC, Hoffmann U, Pencina K, Shadwick SD, Vasan RS, O'Donnell CJ, Fox CS. Association of lifestyle factors with abdominal subcutaneous and visceral adiposity: the Framingham Heart Study. Diabetes Care. 2009 Mar; 32(3):505-10.
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  189. Pou KM, Massaro JM, Hoffmann U, Lieb K, Vasan RS, O'Donnell CJ, Fox CS. Patterns of abdominal fat distribution: the Framingham Heart Study. Diabetes Care. 2009 Mar; 32(3):481-5.
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  190. Kathiresan S, Willer CJ, Peloso GM, Demissie S, Musunuru K, Schadt EE, Kaplan L, Bennett D, Li Y, Tanaka T, Voight BF, Bonnycastle LL, Jackson AU, Crawford G, Surti A, Guiducci C, Burtt NP, Parish S, Clarke R, Zelenika D, Kubalanza KA, Morken MA, Scott LJ, Stringham HM, Galan P, Swift AJ, Kuusisto J, Bergman RN, Sundvall J, Laakso M, Ferrucci L, Scheet P, Sanna S, Uda M, Yang Q, Lunetta KL, Dupuis J, de Bakker PI, O'Donnell CJ, Chambers JC, Kooner JS, Hercberg S, Meneton P, Lakatta EG, Scuteri A, Schlessinger D, Tuomilehto J, Collins FS, Groop L, Altshuler D, Collins R, Lathrop GM, Melander O, Salomaa V, Peltonen L, Orho-Melander M, Ordovas JM, Boehnke M, Abecasis GR, Mohlke KL, Cupples LA. Common variants at 30 loci contribute to polygenic dyslipidemia. Nat Genet. 2009 Jan; 41(1):56-65.
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  191. Lee EJ, Woodske ME, Zou B, O'Donnell CP. Dynamic arterial blood gas analysis in conscious, unrestrained C57BL/6J mice during exposure to intermittent hypoxia. J Appl Physiol. 2009 Jul; 107(1):290-4.
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  192. Frankel DS, Meigs JB, Massaro JM, Wilson PW, O'Donnell CJ, D'Agostino RB, Tofler GH. Von Willebrand factor, type 2 diabetes mellitus, and risk of cardiovascular disease: the framingham offspring study. Circulation. 2008 Dec 9; 118(24):2533-9.
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  193. Wilson PW, Pencina M, Jacques P, Selhub J, D'Agostino R, O'Donnell CJ. C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study. Circ Cardiovasc Qual Outcomes. 2008 Nov; 1(2):92-7.
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  194. Kalichman L, Li L, Kim DH, Guermazi A, Berkin V, O'Donnell CJ, Hoffmann U, Cole R, Hunter DJ. Facet joint osteoarthritis and low back pain in the community-based population. Spine (Phila Pa 1976). 2008 Nov 1; 33(23):2560-5.
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  195. Johnson AD, Handsaker RE, Pulit SL, Nizzari MM, O'Donnell CJ, de Bakker PI. SNAP: a web-based tool for identification and annotation of proxy SNPs using HapMap. Bioinformatics. 2008 Dec 15; 24(24):2938-9.
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  196. Fernandez AB, Keyes MJ, Pencina M, D'Agostino R, O'Donnell CJ, Thompson PD. Relation of corneal arcus to cardiovascular disease (from the Framingham Heart Study data set). Am J Cardiol. 2009 Jan 1; 103(1):64-6.
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  197. O'Donnell CJ, Nabel EG. Cardiovascular genomics, personalized medicine, and the National Heart, Lung, and Blood Institute: part I: the beginning of an era. Circ Cardiovasc Genet. 2008 Oct; 1(1):51-7.
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  198. Young JA, Hwang SJ, Sarnak MJ, Hoffmann U, Massaro JM, Levy D, Benjamin EJ, Larson MG, Vasan RS, O'Donnell CJ, Fox CS. Association of visceral and subcutaneous adiposity with kidney function. Clin J Am Soc Nephrol. 2008 Nov; 3(6):1786-91.
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  199. Hivert MF, Manning AK, McAteer JB, Florez JC, Dupuis J, Fox CS, O'Donnell CJ, Cupples LA, Meigs JB. Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study. Diabetes. 2008 Dec; 57(12):3353-9.
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  200. Hoffmann U, Massaro JM, Fox CS, Manders E, O'Donnell CJ. Defining normal distributions of coronary artery calcium in women and men (from the Framingham Heart Study). Am J Cardiol. 2008 Nov 1; 102(9):1136-41, 1141.e1.
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  201. Shea MK, Dallal GE, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Gundberg CM, Peterson JW, Booth SL. Vitamin K, circulating cytokines, and bone mineral density in older men and women. Am J Clin Nutr. 2008 Aug; 88(2):356-63.
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  202. Das RR, Seshadri S, Beiser AS, Kelly-Hayes M, Au R, Himali JJ, Kase CS, Benjamin EJ, Polak JF, O'Donnell CJ, Yoshita M, D'Agostino RB, DeCarli C, Wolf PA. Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study. Stroke. 2008 Nov; 39(11):2929-35.
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  203. Speliotes EK, Massaro JM, Hoffmann U, Foster MC, Sahani DV, Hirschhorn JN, O'Donnell CJ, Fox CS. Liver fat is reproducibly measured using computed tomography in the Framingham Heart Study. J Gastroenterol Hepatol. 2008 Jun; 23(6):894-9.
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  204. Parikh NI, Hwang SJ, Larson MG, Hoffmann U, Levy D, Meigs JB, O'Donnell CJ, Fox CS. Indexes of kidney function and coronary artery and abdominal aortic calcium (from the Framingham Offspring Study). Am J Cardiol. 2008 Aug 15; 102(4):440-3.
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  205. O'Donnell CJ, Demissie S, Kimura M, Levy D, Gardner JP, White C, D'Agostino RB, Wolf PA, Polak J, Cupples LA, Aviv A. Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2008 Jun; 28(6):1165-71.
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  206. Lasky-Su J, Lyon HN, Emilsson V, Heid IM, Molony C, Raby BA, Lazarus R, Klanderman B, Soto-Quiros ME, Avila L, Silverman EK, Thorleifsson G, Thorsteinsdottir U, Kronenberg F, Vollmert C, Illig T, Fox CS, Levy D, Laird N, Ding X, McQueen MB, Butler J, Ardlie K, Papoutsakis C, Dedoussis G, O'Donnell CJ, Wichmann HE, Celedón JC, Schadt E, Hirschhorn J, Weiss ST, Stefansson K, Lange C. On the replication of genetic associations: timing can be everything! Am J Hum Genet. 2008 Apr; 82(4):849-58.
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  207. Lewis GD, Gona P, Larson MG, Plehn JF, Benjamin EJ, O'Donnell CJ, Levy D, Vasan RS, Wang TJ. Exercise blood pressure and the risk of incident cardiovascular disease (from the Framingham Heart Study). Am J Cardiol. 2008 Jun 1; 101(11):1614-20.
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  208. Reid A, Schneider-Kolsky ME, O'Donnell CJ. Comparison of computed radiography and multi-detector computed tomography in the detection of post mortem metacarpal index. Forensic Sci Int. 2008 May 20; 177(2-3):192-8.
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  210. Levitzky YS, Cupples LA, Murabito JM, Kannel WB, Kiel DP, Wilson PW, Wolf PA, O'Donnell CJ. Prediction of intermittent claudication, ischemic stroke, and other cardiovascular disease by detection of abdominal aortic calcific deposits by plain lumbar radiographs. Am J Cardiol. 2008 Feb 1; 101(3):326-31.
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  211. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS, O'Donnell CJ, Fox CS. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: the Framingham Heart Study. Circulation. 2008 Feb 5; 117(5):605-13.
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  212. Loomba R, Hwang SJ, O'Donnell CJ, Ellison RC, Vasan RS, D'Agostino RB, Liang TJ, Fox CS. Parental obesity and offspring serum alanine and aspartate aminotransferase levels: the Framingham heart study. Gastroenterology. 2008 Apr; 134(4):953-9.
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  213. Govindaraju DR, Cupples LA, Kannel WB, O'Donnell CJ, Atwood LD, D'Agostino RB, Fox CS, Larson M, Levy D, Murabito J, Vasan RS, Splansky GL, Wolf PA, Benjamin EJ. Genetics of the Framingham Heart Study population. Adv Genet. 2008; 62:33-65.
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  214. Rosamond W, Flegal K, Furie K, Go A, Greenlund K, Haase N, Hailpern SM, Ho M, Howard V, Kissela B, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell C, Roger V, Sorlie P, Steinberger J, Thom T, Wilson M, Hong Y. Heart disease and stroke statistics--2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2008 Jan 29; 117(4):e25-146.
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  215. Preis SR, O'Donnell CJ. Coronary heart disease risk assessment by traditional risk factors and newer subclinical disease imaging: is a "one-size-fits-all" approach the best option? Arch Intern Med. 2007 Dec 10; 167(22):2399-401.
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  216. Dhingra R, Gona P, Nam BH, D'Agostino RB, Wilson PW, Benjamin EJ, O'Donnell CJ. C-reactive protein, inflammatory conditions, and cardiovascular disease risk. Am J Med. 2007 Dec; 120(12):1054-62.
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  217. Yokoe T, Alonso LC, Romano LC, Rosa TC, O'Doherty RM, Garcia-Ocana A, Minoguchi K, O'Donnell CP. Intermittent hypoxia reverses the diurnal glucose rhythm and causes pancreatic beta-cell replication in mice. J Physiol. 2008 Feb 1; 586(3):899-911.
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  218. Shea MK, Booth SL, Massaro JM, Jacques PF, D'Agostino RB, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Kathiresan S, Keaney JF, Vasan RS, Benjamin EJ. Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol. 2008 Feb 1; 167(3):313-20.
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  219. Oyama N, Gona P, Salton CJ, Chuang ML, Jhaveri RR, Blease SJ, Manning AR, Lahiri M, Botnar RM, Levy D, Larson MG, O'Donnell CJ, Manning WJ. Differential impact of age, sex, and hypertension on aortic atherosclerosis: the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2008 Jan; 28(1):155-9.
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  220. Yang Q, Kathiresan S, Lin JP, Tofler GH, O'Donnell CJ. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. BMC Med Genet. 2007; 8 Suppl 1:S12.
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  221. Newton-Cheh C, Guo CY, Wang TJ, O'donnell CJ, Levy D, Larson MG. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. BMC Med Genet. 2007; 8 Suppl 1:S7.
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  223. Vasan RS, Larson MG, Aragam J, Wang TJ, Mitchell GF, Kathiresan S, Newton-Cheh C, Vita JA, Keyes MJ, O'Donnell CJ, Levy D, Benjamin EJ. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. BMC Med Genet. 2007; 8 Suppl 1:S2.
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  224. Larson MG, Atwood LD, Benjamin EJ, Cupples LA, D'Agostino RB, Fox CS, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Murabito JM, Newton-Cheh C, O'Donnell CJ, Seshadri S, Vasan RS, Wang TJ, Wolf PA, Levy D. Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes. BMC Med Genet. 2007; 8 Suppl 1:S5.
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  225. Parikh NI, Hwang SJ, Larson MG, Cupples LA, Fox CS, Manders ES, Murabito JM, Massaro JM, Hoffmann U, O'Donnell CJ. Parental occurrence of premature cardiovascular disease predicts increased coronary artery and abdominal aortic calcification in the Framingham Offspring and Third Generation cohorts. Circulation. 2007 Sep 25; 116(13):1473-81.
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  226. Samelson EJ, Cupples LA, Broe KE, Hannan MT, O'Donnell CJ, Kiel DP. Vascular calcification in middle age and long-term risk of hip fracture: the Framingham Study. J Bone Miner Res. 2007 Sep; 22(9):1449-54.
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  227. Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG, Keaney JF, Meigs JB, Lipinska I, Kathiresan S, Murabito JM, O'Donnell CJ, Benjamin EJ, Fox CS. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation. 2007 Sep 11; 116(11):1234-41.
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  228. Newton-Cheh C, Guo CY, Larson MG, Musone SL, Surti A, Camargo AL, Drake JA, Benjamin EJ, Levy D, D'Agostino RB, Hirschhorn JN, O'donnell CJ. Common genetic variation in KCNH2 is associated with QT interval duration: the Framingham Heart Study. Circulation. 2007 Sep 4; 116(10):1128-36.
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  229. Ingelsson E, Sullivan LM, Fox CS, Murabito JM, Benjamin EJ, Polak JF, Meigs JB, Keyes MJ, O'Donnell CJ, Wang TJ, D'Agostino RB, Wolf PA, Vasan RS. Burden and prognostic importance of subclinical cardiovascular disease in overweight and obese individuals. Circulation. 2007 Jul 24; 116(4):375-84.
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  230. Lin JP, O'Donnell CJ, Jin L, Fox C, Yang Q, Cupples LA. Evidence for linkage of red blood cell size and count: genome-wide scans in the Framingham Heart Study. Am J Hematol. 2007 Jul; 82(7):605-10.
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  231. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, Vasan RS, Murabito JM, Meigs JB, Cupples LA, D'Agostino RB, O'Donnell CJ. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007 Jul 3; 116(1):39-48.
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  232. Ingelsson E, Larson MG, Vasan RS, O'Donnell CJ, Yin X, Hirschhorn JN, Newton-Cheh C, Drake JA, Musone SL, Heard-Costa NL, Benjamin EJ, Levy D, Atwood LD, Wang TJ, Kathiresan S. Heritability, linkage, and genetic associations of exercise treadmill test responses. Circulation. 2007 Jun 12; 115(23):2917-24.
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  233. Arnett DK, Baird AE, Barkley RA, Basson CT, Boerwinkle E, Ganesh SK, Herrington DM, Hong Y, Jaquish C, McDermott DA, O'Donnell CJ. Relevance of genetics and genomics for prevention and treatment of cardiovascular disease: a scientific statement from the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group. Circulation. 2007 Jun 5; 115(22):2878-901.
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  234. Thakore AH, Guo CY, Larson MG, Corey D, Wang TJ, Vasan RS, D'Agostino RB, Lipinska I, Keaney JF, Benjamin EJ, O'Donnell CJ. Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). Am J Cardiol. 2007 Jun 1; 99(11):1598-602.
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  235. Mitchell GF, Guo CY, Kathiresan S, Vasan RS, Larson MG, Vita JA, Keyes MJ, Vyas M, Newton-Cheh C, Musone SL, Camargo AL, Drake JA, Levy D, O'Donnell CJ, Hirschhorn JN, Benjamin EJ. Vascular stiffness and genetic variation at the endothelial nitric oxide synthase locus: the Framingham Heart study. Hypertension. 2007 Jun; 49(6):1285-90.
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  236. Tiwari V, O'donnell C, Copeland RJ, Scarlett T, Liu J, Shukla D. Soluble 3-O-sulfated heparan sulfate can trigger herpes simplex virus type 1 entry into resistant Chinese hamster ovary (CHO-K1) cells. J Gen Virol. 2007 Apr; 88(Pt 4):1075-9.
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  237. Alonso LC, Yokoe T, Zhang P, Scott DK, Kim SK, O'Donnell CP, Garcia-Ocaña A. Glucose infusion in mice: a new model to induce beta-cell replication. Diabetes. 2007 Jul; 56(7):1792-801.
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  238. Splansky GL, Corey D, Yang Q, Atwood LD, Cupples LA, Benjamin EJ, D'Agostino RB, Fox CS, Larson MG, Murabito JM, O'Donnell CJ, Vasan RS, Wolf PA, Levy D. The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: design, recruitment, and initial examination. Am J Epidemiol. 2007 Jun 1; 165(11):1328-35.
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  239. Ingelsson E, Sullivan LM, Murabito JM, Fox CS, Benjamin EJ, Polak JF, Meigs JB, Keyes MJ, O'Donnell CJ, Wang TJ, D'Agostino RB, Wolf PA, Vasan RS. Prevalence and prognostic impact of subclinical cardiovascular disease in individuals with the metabolic syndrome and diabetes. Diabetes. 2007 Jun; 56(6):1718-26.
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  240. Minoguchi K, Yokoe T, Tazaki T, Minoguchi H, Oda N, Tanaka A, Yamamoto M, Ohta S, O'Donnell CP, Adachi M. Silent brain infarction and platelet activation in obstructive sleep apnea. Am J Respir Crit Care Med. 2007 Mar 15; 175(6):612-7.
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  241. Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, Zhu X, Thorleifsson G, Gunnarsdottir S, Walters GB, Thorsteinsdottir U, Kong A, Gulcher J, Nguyen TT, Scherag A, Pfeufer A, Meitinger T, Brönner G, Rief W, Soto-Quiros ME, Avila L, Klanderman B, Raby BA, Silverman EK, Weiss ST, Laird N, Ding X, Groop L, Tuomi T, Isomaa B, Bengtsson K, Butler JL, Cooper RS, Fox CS, O'Donnell CJ, Vollmert C, Celedón JC, Wichmann HE, Hebebrand J, Stefansson K, Lange C, Hirschhorn JN. The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet. 2007 Apr 27; 3(4):e61.
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  242. Newton-Cheh C, Guo CY, Gona P, Larson MG, Benjamin EJ, Wang TJ, Kathiresan S, O'Donnell CJ, Musone SL, Camargo AL, Drake JA, Levy D, Hirschhorn JN, Vasan RS. Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample. Hypertension. 2007 Apr; 49(4):846-56.
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  243. Dupuis J, O'Donnell CJ. Interpreting results of large-scale genetic association studies: separating gold from fool's gold. JAMA. 2007 Feb 7; 297(5):529-31.
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  244. Iiyori N, Alonso LC, Li J, Sanders MH, Garcia-Ocana A, O'Doherty RM, Polotsky VY, O'Donnell CP. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am J Respir Crit Care Med. 2007 Apr 15; 175(8):851-7.
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  245. Polotsky VY, O'Donnell CP. Genomics of sleep-disordered breathing. Proc Am Thorac Soc. 2007 Jan; 4(1):121-6.
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  246. Cupples LA, Arruda HT, Benjamin EJ, D'Agostino RB, Demissie S, DeStefano AL, Dupuis J, Falls KM, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Kathiresan S, Kiel DP, Laramie JM, Larson MG, Levy D, Liu CY, Lunetta KL, Mailman MD, Manning AK, Meigs JB, Murabito JM, Newton-Cheh C, O'Connor GT, O'Donnell CJ, Pandey M, Seshadri S, Vasan RS, Wang ZY, Wilk JB, Wolf PA, Yang Q, Atwood LD. The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. BMC Med Genet. 2007; 8 Suppl 1:S1.
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  247. O'Donnell CP. Metabolic consequences of intermittent hypoxia. Adv Exp Med Biol. 2007; 618:41-9.
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  248. Rosamond W, Flegal K, Friday G, Furie K, Go A, Greenlund K, Haase N, Ho M, Howard V, Kissela B, Kissela B, Kittner S, Lloyd-Jones D, McDermott M, Meigs J, Moy C, Nichol G, O'Donnell CJ, Roger V, Rumsfeld J, Sorlie P, Steinberger J, Thom T, Wasserthiel-Smoller S, Hong Y. Heart disease and stroke statistics--2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2007 Feb 6; 115(5):e69-171.
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  249. Goff DC, Brass L, Braun LT, Croft JB, Flesch JD, Fowkes FG, Hong Y, Howard V, Huston S, Jencks SF, Luepker R, Manolio T, O'Donnell C, Robertson RM, Rosamond W, Rumsfeld J, Sidney S, Zheng ZJ. Essential features of a surveillance system to support the prevention and management of heart disease and stroke: a scientific statement from the American Heart Association Councils on Epidemiology and Prevention, Stroke, and Cardiovascular Nursing and the Interdisciplinary Working Groups on Quality of Care and Outcomes Research and Atherosclerotic Peripheral Vascular Disease. Circulation. 2007 Jan 2; 115(1):127-55.
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  250. Kathiresan S, Larson MG, Keyes MJ, Polak JF, Wolf PA, D'Agostino RB, Jaffer FA, Clouse ME, Levy D, Manning WJ, O'Donnell CJ. Assessment by cardiovascular magnetic resonance, electron beam computed tomography, and carotid ultrasonography of the distribution of subclinical atherosclerosis across Framingham risk strata. Am J Cardiol. 2007 Feb 1; 99(3):310-4.
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  251. Li J, Savransky V, Nanayakkara A, Smith PL, O'Donnell CP, Polotsky VY. Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia. J Appl Physiol. 2007 Feb; 102(2):557-63.
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  252. Lin JP, O'Donnell CJ, Schwaiger JP, Cupples LA, Lingenhel A, Hunt SC, Yang S, Kronenberg F. Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study. Circulation. 2006 Oct 3; 114(14):1476-81.
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  253. O'Donnell CJ, Shea MK, Price PA, Gagnon DR, Wilson PW, Larson MG, Kiel DP, Hoffmann U, Ferencik M, Clouse ME, Williamson MK, Cupples LA, Dawson-Hughes B, Booth SL. Matrix Gla protein is associated with risk factors for atherosclerosis but not with coronary artery calcification. Arterioscler Thromb Vasc Biol. 2006 Dec; 26(12):2769-74.
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  254. Lee DS, Pencina MJ, Benjamin EJ, Wang TJ, Levy D, O'Donnell CJ, Nam BH, Larson MG, D'Agostino RB, Vasan RS. Association of parental heart failure with risk of heart failure in offspring. N Engl J Med. 2006 Jul 13; 355(2):138-47.
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  255. Morita H, Larson MG, Barr SC, Vasan RS, O'Donnell CJ, Hirschhorn JN, Levy D, Corey D, Seidman CE, Seidman JG, Benjamin EJ. Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study. Circulation. 2006 Jun 13; 113(23):2697-705.
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  256. Levy D, DePalma SR, Benjamin EJ, O'Donnell CJ, Parise H, Hirschhorn JN, Vasan RS, Izumo S, Larson MG. Phenotype-genotype association grid: a convenient method for summarizing multiple association analyses. BMC Genet. 2006; 7:30.
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  257. Allen LA, O'Donnell CJ, Camargo CA, Giugliano RP, Lloyd-Jones DM. Comparison of long-term mortality across the spectrum of acute coronary syndromes. Am Heart J. 2006 May; 151(5):1065-71.
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  258. Meigs JB, Dupuis J, Liu C, O'Donnell CJ, Fox CS, Kathiresan S, Gabriel SB, Larson MG, Yang Q, Herbert AG, Wilson PW, Feng D, Tofler GH, Cupples LA. PAI-1 Gene 4G/5G polymorphism and risk of type 2 diabetes in a population-based sample. Obesity (Silver Spring). 2006 May; 14(5):753-8.
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  259. Arking DE, Pfeufer A, Post W, Kao WH, Newton-Cheh C, Ikeda M, West K, Kashuk C, Akyol M, Perz S, Jalilzadeh S, Illig T, Gieger C, Guo CY, Larson MG, Wichmann HE, Marbán E, O'Donnell CJ, Hirschhorn JN, Kääb S, Spooner PM, Meitinger T, Chakravarti A. A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization. Nat Genet. 2006 Jun; 38(6):644-51.
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  260. Kathiresan S, Yang Q, Larson MG, Camargo AL, Tofler GH, Hirschhorn JN, Gabriel SB, O'Donnell CJ. Common genetic variation in five thrombosis genes and relations to plasma hemostatic protein level and cardiovascular disease risk. Arterioscler Thromb Vasc Biol. 2006 Jun; 26(6):1405-12.
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  261. Fox CS, Guo CY, Larson MG, Vasan RS, Parise H, O'Donnell CJ, D'Agostino RB, Keaney JF, Benjamin EJ. Relations of inflammation and novel risk factors to valvular calcification. Am J Cardiol. 2006 May 15; 97(10):1502-5.
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  262. Kathiresan S, Larson MG, Vasan RS, Guo CY, Gona P, Keaney JF, Wilson PW, Newton-Cheh C, Musone SL, Camargo AL, Drake JA, Levy D, O'Donnell CJ, Hirschhorn JN, Benjamin EJ. Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation. 2006 Mar 21; 113(11):1415-23.
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  263. Raju SV, Zheng M, Schuleri KH, Phan AC, Bedja D, Saraiva RM, Yiginer O, Vandegaer K, Gabrielson KL, O'donnell CP, Berkowitz DE, Barouch LA, Hare JM. Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4222-7.
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  264. Elosua R, Ordovas JM, Cupples LA, Lai CQ, Demissie S, Fox CS, Polak JF, Wolf PA, D'Agostino RB, O'Donnell CJ. Variants at the APOA5 locus, association with carotid atherosclerosis, and modification by obesity: the Framingham Study. J Lipid Res. 2006 May; 47(5):990-6.
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  265. Meigs JB, O'donnell CJ, Tofler GH, Benjamin EJ, Fox CS, Lipinska I, Nathan DM, Sullivan LM, D'Agostino RB, Wilson PW. Hemostatic markers of endothelial dysfunction and risk of incident type 2 diabetes: the Framingham Offspring Study. Diabetes. 2006 Feb; 55(2):530-7.
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  266. Hoffmann U, Siebert U, Bull-Stewart A, Achenbach S, Ferencik M, Moselewski F, Brady TJ, Massaro JM, O'Donnell CJ. Evidence for lower variability of coronary artery calcium mineral mass measurements by multi-detector computed tomography in a community-based cohort--consequences for progression studies. Eur J Radiol. 2006 Mar; 57(3):396-402.
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  267. Elosua R, Cupples LA, Fox CS, Polak JF, D'Agostino RA, Wolf PA, O'Donnell CJ, Ordovas JM. Association between well-characterized lipoprotein-related genetic variants and carotid intimal medial thickness and stenosis: The Framingham Heart Study. Atherosclerosis. 2006 Nov; 189(1):222-8.
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  268. Thom T, Haase N, Rosamond W, Howard VJ, Rumsfeld J, Manolio T, Zheng ZJ, Flegal K, O'Donnell C, Kittner S, Lloyd-Jones D, Goff DC, Hong Y, Adams R, Friday G, Furie K, Gorelick P, Kissela B, Marler J, Meigs J, Roger V, Sidney S, Sorlie P, Steinberger J, Wasserthiel-Smoller S, Wilson M, Wolf P. Heart disease and stroke statistics--2006 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2006 Feb 14; 113(6):e85-151.
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  269. Murabito JM, Pencina MJ, Nam BH, D'Agostino RB, Wang TJ, Lloyd-Jones D, Wilson PW, O'Donnell CJ. Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults. JAMA. 2005 Dec 28; 294(24):3117-23.
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  270. Fox CS, Larson MG, Vasan RS, Guo CY, Parise H, Levy D, Leip EP, O'donnell CJ, D'Agostino RB, Benjamin EJ. Cross-sectional association of kidney function with valvular and annular calcification: the Framingham heart study. J Am Soc Nephrol. 2006 Feb; 17(2):521-7.
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  271. Wilson PW, Nam BH, Pencina M, D'Agostino RB, Benjamin EJ, O'Donnell CJ. C-reactive protein and risk of cardiovascular disease in men and women from the Framingham Heart Study. Arch Intern Med. 2005 Nov 28; 165(21):2473-8.
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  272. Polotsky VY, Rubin AE, Balbir A, Dean T, Smith PL, Schwartz AR, O'Donnell CP. Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse. Sleep Med. 2006 Jan; 7(1):7-16.
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  273. Low AF, O'Donnell CJ, Kathiresan S, Everett B, Chae CU, Shaw SY, Ellinor PT, MacRae CA. Aging syndrome genes and premature coronary artery disease. BMC Med Genet. 2005 Oct 31; 6:38.
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  274. Iiyori N, Shirahata M, O'Donnell CP. Genetic background affects cardiovascular responses to obstructive and simulated apnea. Physiol Genomics. 2005 Dec 14; 24(1):65-72.
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  275. Kathiresan S, Gabriel SB, Yang Q, Lochner AL, Larson MG, Levy D, Tofler GH, Hirschhorn JN, O'Donnell CJ. Comprehensive survey of common genetic variation at the plasminogen activator inhibitor-1 locus and relations to circulating plasminogen activator inhibitor-1 levels. Circulation. 2005 Sep 20; 112(12):1728-35.
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  276. Ilkhanoff L, O'Donnell CJ, Camargo CA, O'Halloran TD, Giugliano RP, Lloyd-Jones DM. Usefulness of the TIMI Risk Index in predicting short- and long-term mortality in patients with acute coronary syndromes. Am J Cardiol. 2005 Sep 15; 96(6):773-7.
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  277. Kathiresan S, Larson MG, Vasan RS, Guo CY, Vita JA, Mitchell GF, Keyes MJ, Newton-Cheh C, Musone SL, Lochner AL, Drake JA, Levy D, O'Donnell CJ, Hirschhorn JN, Benjamin EJ. Common genetic variation at the endothelial nitric oxide synthase locus and relations to brachial artery vasodilator function in the community. Circulation. 2005 Sep 6; 112(10):1419-27.
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  278. Li J, Thorne LN, Punjabi NM, Sun CK, Schwartz AR, Smith PL, Marino RL, Rodriguez A, Hubbard WC, O'Donnell CP, Polotsky VY. Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res. 2005 Sep 30; 97(7):698-706.
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  279. McDermott DH, Yang Q, Kathiresan S, Cupples LA, Massaro JM, Keaney JF, Larson MG, Vasan RS, Hirschhorn JN, O'Donnell CJ, Murphy PM, Benjamin EJ. CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. Circulation. 2005 Aug 23; 112(8):1113-20.
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  280. Li J, Grigoryev DN, Ye SQ, Thorne L, Schwartz AR, Smith PL, O'Donnell CP, Polotsky VY. Chronic intermittent hypoxia upregulates genes of lipid biosynthesis in obese mice. J Appl Physiol. 2005 Nov; 99(5):1643-8.
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  281. Moselewski F, O'Donnell CJ, Achenbach S, Ferencik M, Massaro J, Nguyen A, Cury RC, Abbara S, Jang IK, Brady TJ, Hoffmann U. Calcium concentration of individual coronary calcified plaques as measured by multidetector row computed tomography. Circulation. 2005 Jun 21; 111(24):3236-41.
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  282. O'Donnell CJ. Translating the Human Genome Project into prevention of myocardial infarction and stroke--getting close? JAMA. 2005 May 11; 293(18):2277-9.
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  283. Fox CS, Evans JC, Larson MG, Lloyd-Jones DM, O'Donnell CJ, Sorlie PD, Manolio TA, Kannel WB, Levy D. A comparison of death certificate out-of-hospital coronary heart disease death with physician-adjudicated sudden cardiac death. Am J Cardiol. 2005 Apr 1; 95(7):856-9.
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  284. Newton-Cheh C, Larson MG, Corey DC, Benjamin EJ, Herbert AG, Levy D, D'Agostino RB, O'Donnell CJ. QT interval is a heritable quantitative trait with evidence of linkage to chromosome 3 in a genome-wide linkage analysis: The Framingham Heart Study. Heart Rhythm. 2005 Mar; 2(3):277-84.
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  285. Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O'Donnell CJ, Brown NJ, Waterman MR, Capdevila JH. Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension. Circulation. 2005 Jan 4; 111(1):63-9.
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  286. Fox CS, Larson MG, Keyes MJ, Levy D, Clouse ME, Culleton B, O'Donnell CJ. Kidney function is inversely associated with coronary artery calcification in men and women free of cardiovascular disease: the Framingham Heart Study. Kidney Int. 2004 Nov; 66(5):2017-21.
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  287. Campen MJ, Tagaito Y, Li J, Balbir A, Tankersley CG, Smith P, Schwartz A, O'Donnell CP. Phenotypic variation in cardiovascular responses to acute hypoxic and hypercapnic exposure in mice. Physiol Genomics. 2004 Dec 15; 20(1):15-20.
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  288. O'Donnell CJ. Family history, subclinical atherosclerosis, and coronary heart disease risk: barriers and opportunities for the use of family history information in risk prediction and prevention. Circulation. 2004 Oct 12; 110(15):2074-6.
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  289. Groeben H, Meier S, Brown RH, O'Donnell CP, Mitzner W, Tankersley CG. The effect of leptin on the ventilatory responseto hyperoxia. Exp Lung Res. 2004 Oct-Nov; 30(7):559-70.
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  290. Balady GJ, Larson MG, Vasan RS, Leip EP, O'Donnell CJ, Levy D. Usefulness of exercise testing in the prediction of coronary disease risk among asymptomatic persons as a function of the Framingham risk score. Circulation. 2004 Oct 5; 110(14):1920-5.
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  291. Cury RC, Ferencik M, Hoffmann U, Ferullo A, Moselewski F, Abbara S, Booth SL, O'Donnell CJ, Brady TJ, Achenbach S. Epidemiology and association of vascular and valvular calcium quantified by multidetector computed tomography in elderly asymptomatic subjects. Am J Cardiol. 2004 Aug 1; 94(3):348-51.
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  292. Elosua R, Ordovas JM, Cupples LA, Fox CS, Polak JF, Wolf PA, D'Agostino RA, O'Donnell CJ. Association of APOE genotype with carotid atherosclerosis in men and women: the Framingham Heart Study. J Lipid Res. 2004 Oct; 45(10):1868-75.
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  293. Manolio TA, Boerwinkle E, O'Donnell CJ, Wilson AF. Genetics of ultrasonographic carotid atherosclerosis. Arterioscler Thromb Vasc Biol. 2004 Sep; 24(9):1567-77.
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  294. Newton-Cheh C, Larson M, Kathiresan S, O'Donnell C. On the significance of linkage studies of complex traits. Am J Hum Genet. 2004 Jul; 75(1):151-2; author reply 152-4.
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  295. Newton-Cheh C, O'Donnell CJ. Sex differences and genetic associations with myocardial infarction. JAMA. 2004 Jun 23; 291(24):3008-10.
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  296. Haider AW, Roubenoff R, Wilson PW, Levy D, D'Agostino R, Silbershatz H, O'Donnell CJ. Monocyte cytokine production, systemic inflammation and cardiovascular disease in very elderly men and women: the Framingham Heart Study. Eur J Cardiovasc Prev Rehabil. 2004 Jun; 11(3):214-5.
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  297. Allen LA, O'Donnell CJ, Giugliano RP, Camargo CA, Lloyd-Jones DM. Care concordant with guidelines predicts decreased long-term mortality in patients with unstable angina pectoris and non-ST-elevation myocardial infarction. Am J Cardiol. 2004 May 15; 93(10):1218-22.
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  298. Lloyd-Jones DM, Nam BH, D'Agostino RB, Levy D, Murabito JM, Wang TJ, Wilson PW, O'Donnell CJ. Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring. JAMA. 2004 May 12; 291(18):2204-11.
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  299. Fox CS, Parise H, Vasan RS, Levy D, O'Donnell CJ, D'Agostino RB, Plehn JF, Benjamin EJ. Mitral annular calcification is a predictor for incident atrial fibrillation. Atherosclerosis. 2004 Apr; 173(2):291-4.
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  300. Murabito JM, Nam BH, D'Agostino RB, Lloyd-Jones DM, O'Donnell CJ, Wilson PW. Accuracy of offspring reports of parental cardiovascular disease history: the Framingham Offspring Study. Ann Intern Med. 2004 Mar 16; 140(6):434-40.
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  301. Walsh CR, Larson MG, Kupka MJ, Levy D, Vasan RS, Benjamin EJ, Manning WJ, Clouse ME, O'Donnell CJ. Association of aortic valve calcium detected by electron beam computed tomography with echocardiographic aortic valve disease and with calcium deposits in the coronary arteries and thoracic aorta. Am J Cardiol. 2004 Feb 15; 93(4):421-5.
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  302. Fox CS, Larson MG, Corey D, Feng D, Lindpaintner K, Polak JF, Wolf PA, D'Agostino RB, Tofler GH, O'Donnell CJ. Absence of association between polymorphisms in the hemostatic factor pathway genes and carotid intimal medial thickness: the Framingham Heart Study. Stroke. 2004 Mar; 35(3):e65-7.
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  303. Fox CS, Cupples LA, Chazaro I, Polak JF, Wolf PA, D'Agostino RB, Ordovas JM, O'Donnell CJ. Genomewide linkage analysis for internal carotid artery intimal medial thickness: evidence for linkage to chromosome 12. Am J Hum Genet. 2004 Feb; 74(2):253-61.
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  304. Macrae C, O'donnell CJ. Current and Future Impact of Genomics on the Diagnosis and Management of Cardiovascular Disease. Principles of Molecular Medicine. 2004; In Press.
  305. Ellsworth DL, O'Donnell CJ. Emerging Genomic Technologies and Analytic Methods for Population-and Clinic-Based Research. Human Genome Epidemiology: a Scientific Foundation for Using Genetic Information to Improve Health and Prevent Disease. 2004; Chapter 2.
  306. Lloyd-Jones DM, O'Donnell CJ. Hypertension as a Risk Factor for Stroke: Edpidemiology of Blood Pressure Risks and Evidence for Treatment Benefits. Handbook of Stroke Prevention. 2004; In Press.
  307. O'Donnell Cj, Hoffman U. Coronary calcium Screening; An Epidemiologic Perspective. CT of the Heart: Principles and Applications. 2004; In Press.
  308. Lloyd-Jones DM, Camargo CA, Allen LA, Giugliano RP, O'Donnell CJ. Predictors of Long-term Mortality After Hospitalization for Primary Unstable Angina PLectoris and Non-ST-Elevation Myocardial Infarction. American Journal of Cardiology. 2003; 92(10):1155-1159.
  309. Lloyd-Jones DM, Camargo CA, Allen LA, Giugliano RP, O'Donnell CJ. Predictors of long-term mortality after hospitalization for primary unstable angina pectoris and non-ST-elevation myocardial infarction. Am J Cardiol. 2003 Nov 15; 92(10):1155-9.
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  310. Polotsky VY, Smaldone MC, Scharf MT, Li J, Tankersley CG, Smith PL, Schwartz AR, O'Donnell CP. Impact of interrupted leptin pathways on ventilatory control. J Appl Physiol. 2004 Mar; 96(3):991-8.
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  311. Drake J, Loomer M, Newton-Cheh C, Lochner A, Levy R, Parise H, Schaffner SF, Gabriel S, Larson M, Benjamin EJ, Daly MJ, O'Donnell CJ, Hirschhorn JN. Efficacy of haplotype-based association approaches. American Journal of Human Genetics. 2003; 108(387).
  312. Cohen RI, Marzouk K, Berkoski P, O'Donnell CP, Polotsky VY, Scharf SM. Body composition and resting energy expenditure in clinically stable, non-weight-losing patients with severe emphysema. Chest. 2003 Oct; 124(4):1365-72.
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  313. Rubin AE, Polotsky VY, Balbir A, Krishnan JA, Schwartz AR, Smith PL, Fitzgerald RS, Tankersley CG, Shirahata M, O'Donnell CP. Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strains. Am J Respir Crit Care Med. 2003 Dec 15; 168(12):1520-7.
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  314. Barouch LA, Berkowitz DE, Harrison RW, O'Donnell CP, Hare JM. Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. Circulation. 2003 Aug 12; 108(6):754-9.
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  315. Polotsky VY, Li J, Punjabi NM, Rubin AE, Smith PL, Schwartz AR, O'Donnell CP. Intermittent hypoxia increases insulin resistance in genetically obese mice. J Physiol. 2003 Oct 1; 552(Pt 1):253-64.
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  316. Wang TJ, Nam BH, D'Agostino RB, Wolf PA, Lloyd-Jones DM, MacRae CA, Wilson PW, Polak JF, O'Donnell CJ. Carotid intima-media thickness is associated with premature parental coronary heart disease: the Framingham Heart Study. Circulation. 2003 Aug 5; 108(5):572-6.
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  317. Punjabi NM, Ahmed MM, Polotsky VY, Beamer BA, O'Donnell CP. Sleep-disordered breathing, glucose intolerance, and insulin resistance. Respir Physiol Neurobiol. 2003 Jul 16; 136(2-3):167-78.
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  318. Ilkhanoff L, O'donnell CJ, Camargo CA, O'Halloran D, Giugliano RP, Lloyd-Jones DM. The TIMI Risk Index Predicts In-hospital and Long-term Mortality in Unselected Patients with Myocardial Infarction. Academy of Emergency Medicine. 2003; 10(5):429-430.
  319. Fox CS, Larson MG, Kupka MJ, Levy D, Clouse M, Culleton B, O'Donnell CJ. Reduced kidney function is associated with subclinical coronary artery calcification: The Framingham Heart Study. Circulation. 2003; 108:IV-730.
  320. Morita H. for the Cardiogenomics Group. Sarcomere protein gene and cardiac hypertrophy in the general population: The Framingham Heart Study. Circulation. 2003; 108:IV-50.
  321. O'Donnell CJ, Yang Q, Lochner A, Larson MG, Kathiresan S, Tofler GH, Gabriel SB. LAssociations of haplotypes of fibrinogen beta, alpha and gamma chain genes on chromosome 4 with circulating fibrinogen levels in men and women. Circulation. 2003; 108:IV-771.
  322. Wilson PW, D'Agostino RB, Nam BH, Benjamin EJ, O'Donnell CJ. C-reactive protein and CVD risk in Framingham. Circulation. 2003; 108:IV-748.
  323. Hoffman U, Bull-Stewart A, Achenbach S, Ferencik M, Brady TJ, O'Donnell CJ. Interscan and interobserver variability of coronary artery calcium measurements in prospectively triggered multislice computed tomography. Circulation. 2003; 108:IV-730.
  324. Fox CS, Evans JC, Larson MG, Sorlie PD, Manolio TA, Lloyd-Jones DM, Kannel W, O'Donnell CJ, Levy D. Death Certificate out-of-hospital cardiac death over estimates sudden cardiac death. Circulation. 2003; 108:IV-318.
  325. Lloyd-Jones DM, Nam BH, D'Agostino RB, Levy D, Murabito JM, Wang TJ, Wilson PW, O'Donnell CJ. Parental history of cardiovascular disease adds predictive information to traditional risk factors and multivariate predicted risk. Circulation. 2003; 108:IV-730.
  326. Gurkan OU, O'Donnell C, Brower R, Ruckdeschel E, Becker PM. Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice. Am J Physiol Lung Cell Mol Physiol. 2003 Sep; 285(3):L710-8.
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  327. Yang Q, Tofler GH, Cupples LA, Larson MG, Feng D, Lindpaintner K, Levy D, D'Agostino RB, O'Donnell CJ. A genome-wide search for genes affecting circulating fibrinogen levels in the Framingham Heart Study. Thromb Res. 2003 Apr 15; 110(1):57-64.
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  328. McDermott DH, Fong AM, Yang Q, Sechler JM, Cupples LA, Merrell MN, Wilson PW, D'Agostino RB, O'Donnell CJ, Patel DD, Murphy PM. Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans. J Clin Invest. 2003 Apr; 111(8):1241-50.
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  329. Fox CS, Parise H, Vasan RS, Levy D, O'Donnell CJ, D'Agostino RB Sr, Benjamin EJ. Mitral Annular Calcification is Associated with Incident Atrial Fibrillation and All-Cause Mortality: The Framingham Heart Study. Circulation. 2003; 107(11):1492-1496.
  330. Fox CS, Vasan RS, Parise H, Levy D, O'Donnell CJ, D'Agostino RB, Benjamin EJ. Mitral annular calcification predicts cardiovascular morbidity and mortality: the Framingham Heart Study. Circulation. 2003 Mar 25; 107(11):1492-6.
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  331. O'Halloran D, O'Donnell CJ, Giugliano RP, Camargo CA, Allen L, Lloyd-Jones DM. The TIMI risk index predicts long-term mortality in patients admitted with primary unstable angina. American College of Cardiology Scientific Sessions. 2003.
  332. Smith PL, O'Donnell CP, Allan L, Schwartz AR. A physiologic comparison of nasal and oral positive airway pressure. Chest. 2003 Mar; 123(3):689-94.
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  333. Lin JP, Cupples LA, Wilson PW, Heard-Costa N, O'Donnell CJ. Evidence for a gene influencing serum bilirubin on chromosome 2q telomere: a genomewide scan in the Framingham study. Am J Hum Genet. 2003 Apr; 72(4):1029-34.
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  334. Fox CS, Polak JF, Chazaro I, Cupples A, Wolf PA, D'Agostino RA, O'Donnell CJ. Genetic and environmental contributions to atherosclerosis phenotypes in men and women: heritability of carotid intima-media thickness in the Framingham Heart Study. Stroke. 2003 Feb; 34(2):397-401.
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  335. Fox C, Polak JF, Chazaro I, Cupples A, Wolf PA, D'Agostino R, O'Donnell CJ. . Carotid Intimal Medial Thickness is a Heritable Phenotype: The Framingham Heart Study. Stroke. 2003; 34(2):397-401.
  336. Morita H. For the Cardiogenomics Group. Sarcomere Protein Gene and Cardiac Hypertrophy in the General Population: The Framingham Heart Study. Circulation. 2003; 108:IV-50.
  337. Drake J, Loomer M, Newton-Cheh C, Lochner A, Levy R, Parise H, Schaffner SF, Gabriel S, Larson M, Benjamin EJ, Daly MJ, O'Donnell CJ, Hirschhorn JN. Efficacy of Haplotype-based Association Approaches. AJHG. 2003; 73(Supplement):387.
  338. Ilkhanoff L, O'Donnell CJ, Camargo CA, O'Halloran D, Giugliano RP, Lloyd-Jones DM. The TIMI Risk Index Predicts In-hospital and Long-term Mortality in Unselected Patients with Myocardial Infarction. Academy of Emergency Medicine. 2003; 10(5):429-430.
  339. Wilson PW, D'Agostino RB, Nam BH, Benjamin EJ, O'Donnell CJ. C-Reactive Protein and CVD Risk in Framingham. Circulation. 2003; 108:IV-748.
  340. Hoffman U, Bull-Stewart A, Achenbach S, Ferencik M, Brady TJ, O'Donnell CJ. Interscan and Interobserver Variability of Coronary Artery Calcium Measurements in Prospectively Triggered Multislice Computed Tomography. Circulation. 2003; 108:IV-529.
  341. O'Donnell CJ, Yang Q, Lochner A, Larson MG, Kathiresan S, Tofler GH, Gabriel SB. Associations of Haplotypes of Fibrinogen Beta, Alpha and Gamma Chain Genes on Chromosome 4 with Circulating Fibrinogen Levels in Mebn and Women. Circulation. 2003; 108:IV-771.
  342. O'Halloran D, O'Donnell CJ, Giugliano RP, Camargo CA, Allen L, Lloyd-Jones DM. The TIMI risk index predicts long-term mortality in patients admitted with primary unstable angina. American College of cardiology Scientific Sessions. 2003.
  343. Fox CS, Evans JC, Larson MG, Sorlie PD, Manolio TA, Lloyd-Jones DM, Kannel W, O'Donnell CJ, Levy D. Death Certificate Out-of-Hospital Cardiac Death Overestimates Sudden Cardiac Death. Circulation. 2003; 108:IV-318.
  344. Lloyd-Jones DM, Nam BH, D'Agostino RB, Levy D, Murabito JM, Wang TJ, Wilson PW, O'Donnell CJ. Parental History of Cardiovascular Disease Adds Predictive Information to Traditional Risk Factors and Multivariate Predicted Risk. Circulation. 2003; 108:IV-725.
  345. Fox CS, Larsdon MG, Kupka MJ, Levy D, Clouse M, Culleton B, O'Donnell CJ. Reduced Kidney Function is Assiociated with Subclinical Coronary Artery Calcification: The Framingham Heart Study. Circulation. 2003; 108:IV-730.
  346. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Corey D, Levy D. Genome Scan Linkage Results for Heart Rate Variability in the Framingham Heart Study. American Journal of Cardiology. 2002; 90(12):1290-1293.
  347. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Corey D, Levy D. Genome scan linkage results for heart rate variability (the Framingham Heart Study). Am J Cardiol. 2002 Dec 15; 90(12):1290-3.
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  348. Campen MJ, Tagaito Y, Jenkins TP, Smith PL, Schwartz AR, O'Donnell CP. Phenotypic differences in the hemodynamic response during REM sleep in six strains of inbred mice. Physiol Genomics. 2002 Dec 3; 11(3):227-34.
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  349. Walsh CR, O'Donnell CJ, Camargo CA, Giugliano RP, Lloyd-Jones DM. Elevated serum creatinine is associated with 1-year mortality after acute myocardial infarction. Am Heart J. 2002 Dec; 144(6):1003-11.
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  350. Loomer M, Gabriel SB, Platko J, O'Donnell C, Daly MJ, Lander ES, Hirschhorn JN. The efficacy of using haplotypes to assay common variation in genes. American Society of Human Genetics Annual Meeting. 2002.
  351. Lin JP, Cupples LA, Wilson PWF, Jaquish CE, O'Donnell CJ. Evidence for a Gene Influencing Serum Bilirubin on Chromosome 2qtelomere: a genome-wide scan in the Framingham Offspring Study. American Society of Human Genetics Annual Meeting. 2002.
  352. Haider AW, Wilson PW, Larson MG, Evans JC, Michelson EL, Wolf PA, O'Donnell CJ, Levy D. The association of seropositivity to Helicobacter pylori, Chlamydia pneumoniae, and cytomegalovirus with risk of cardiovascular disease: a prospective study. J Am Coll Cardiol. 2002 Oct 16; 40(8):1408-13.
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  353. Morshedi-Meibodi A, Larson MG, Levy D, O'Donnell CJ, Vasan RS. Heart rate recovery after treadmill exercise testing and risk of cardiovascular disease events (The Framingham Heart Study). Am J Cardiol. 2002 Oct 15; 90(8):848-52.
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  354. O'Donnell CP, Allan L, Atkinson P, Schwartz AR. The effect of upper airway obstruction and arousal on peripheral arterial tonometry in obstructive sleep apnea. Am J Respir Crit Care Med. 2002 Oct 1; 166(7):965-71.
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  355. Schneider H, Boudewyns A, Smith PL, O'Donnell CP, Canisius S, Stammnitz A, Allan L, Schwartz AR. Modulation of upper airway collapsibility during sleep: influence of respiratory phase and flow regimen. J Appl Physiol. 2002 Oct; 93(4):1365-76.
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  356. Wang TJ, Nam BH, Wilson PW, Wolf PA, Levy D, Polak JF, D'Agostino RB, O'Donnell CJ. Association of C-reactive protein with carotid atherosclerosis in men and women: the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2002 Oct 1; 22(10):1662-7.
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  357. Walsh CR, Cupples LA, Levy D, Kiel DP, Hannan M, Wilson PW, O'Donnell CJ. Abdominal aortic calcific deposits are associated with increased risk for congestive heart failure: the Framingham Heart Study. Am Heart J. 2002 Oct; 144(4):733-9.
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  358. Wang TJ, Larson MG, Levy D, Benjamin EJ, Kupka MJ, Manning WJ, Clouse ME, D'Agostino RB, Wilson PW, O'Donnell CJ. C-reactive protein is associated with subclinical epicardial coronary calcification in men and women: the Framingham Heart Study. Circulation. 2002 Sep 3; 106(10):1189-91.
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  359. Meigs JB, Larson MG, D'Agostino RB, Levy D, Clouse ME, Nathan DM, Wilson PW, O'Donnell CJ. Coronary artery calcification in type 2 diabetes and insulin resistance: the framingham offspring study. Diabetes Care. 2002 Aug; 25(8):1313-9.
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  360. O'Donnell CJ, Chazaro I, Wilson PW, Fox C, Hannan MT, Kiel DP, Cupples LA. Evidence for heritability of abdominal aortic calcific deposits in the Framingham Heart Study. Circulation. 2002 Jul 16; 106(3):337-41.
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  361. O'Donnell CJ, Pasternak RC, O'Gara PT, Dec GW, Mort EA, Brady TJ. "Partner's summary of Current Clinical Evidence for Partner's Physicians: Statement on Coronary Calcium Screening for Coronary Disease Prevention". Brigham and Women's Hospital for Medical Professionals. 2002; (Statement on Coronary Calcium ).
  362. Fox CS, Parise H, Vasan RS, Levy D, O'Donnell CJ, D'Agostino RB Sr, Benjamin EJ. Mitral Annular Calcification Is Associated with Incident Agrial Fibarillation and All-Cause Mortality: The Framingham Heart Study. Circulation. 2002; 106:II-559.
  363. Lloyd-Jones DM, Nam B, D'Agostino RB Sr, Wilson PWF, Levy D, Murabito JM, O'Donnell CJ. Validated Parental History as a Risk Factor for Cardiovascular Disease. Circulation. 2002; 106:II-762.
  364. Allen LA, O'Donnell CJ, Giugliano RP, Camargo CA, Lloyd-Jones DM. Unstable Angina Guideline Concordance Predicts Decreased Mortality up to Ten Years after Hospitalization. Circulation. 2002; 106:II-762.
  365. Lloyd-Jones DM, Nam BH, D'Agostino RB Sr, Wilson PWF, Levy D, Murabito JM, O'Donnell CJ. Validated Parental History as a Risk Factor for Cardiovascular Disease. Circulation. 2002; 106:II-442.
  366. Jaffer FA, O'Donnell CJ, Larson MG, Chan SK, Kissinger KV, Kupka MJ, Salton C, Botnar RM, Levy D, Manning WJ. Age and sex distribution of subclinical aortic atherosclerosis: a magnetic resonance imaging examination of the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2002 May 1; 22(5):849-54.
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  367. Maroo A, O'Donnell CJ. Current Practice and Future Promise for Clinical Noninvasive Measurements of Subclinical Atheroclerotic Disease in the Elderly. Americal Journal of Geriatric Cardiology. 2002; 11(2):108-116.
  368. Baim D, Brady TJ, Casscells SW, Dunne M, Fayad Z, Fuster V, Gazelle S, Heldman A, Hatsukami T, Kinlay S, Lafont A, Lee R, Libby P, Meier B, Muller JE, Naghavi M, O'Donnell C, Perin E, Rekhter M, Rumberger J, Russell M, Schwartz R, Selwyn A, Strauss HW, Tearney G, Tomaru T, Tuzcu EM, Wasserman B. Thoughts on the role of the healing professions and the events of September 11, 2001. Circulation. 2002 Mar 26; 105(12):1509-10.
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  369. Salton CJ, Chuang ML, O'Donnell CJ, Kupka MJ, Larson MG, Kissinger KV, Edelman RR, Levy D, Manning WJ. Gender differences and normal left ventricular anatomy in an adult population free of hypertension. A cardiovascular magnetic resonance study of the Framingham Heart Study Offspring cohort. J Am Coll Cardiol. 2002 Mar 20; 39(6):1055-60.
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  370. Maroo A, O'Donnell CJ. Current practice and future promise for clinical noninvasive measurements of subclinical atherosclerotic disease in the elderly. Am J Geriatr Cardiol. 2002 Mar-Apr; 11(2):108-16; quiz 116-8.
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  371. O'Donnell CJ, Kannel WB. Epidemiologic appraisal of hypertension as a coronary risk factor in the elderly. Am J Geriatr Cardiol. 2002 Mar-Apr; 11(2):86-92.
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  372. Allen LA, O'Donnell CJ, Giugliano RP, Camargo CA, Lloyd-Jones DM. Unstable Angina Guideline Concordance Predicts Decreased Mortality up to Ten-Years after Hospitalization. Circulation. 2002; 106:II-762.
  373. O'Donnell CJ, Kannell WB. Epidemiology of Atherosclerotic Vascular Disease. Pan Vascular Medicine: Integrated Clinical Management. 2002.
  374. Loomer M, Gabriel SB, Platko J, O'Donnell C, Daly MJ, Lander ES, Hirschhorn JN. The Efficacy of Using Haplotypes to Assay Common Variation in Genes. American Society of Human Genetics Annual Meeting. 2002.
  375. Chuang ML, Salton CL, O'Donnell CJ, Kissinger KV, Levy D, Manning WJ. Gender Differences in Detection of Concentric Left Ventricular Geometry by Magnetic Resonance Imaging. Society for Clinical Magnetic Resonance. 2002.
  376. Fox C, Polak JF, Chazaro I, Cupples A, Wolf PA, D'Agostino R, O'Donnell CJ. Carotid Intima-Media Thickness is a Heritable Phenotype: The Framingham Heart Study. Circulation. 2002; 105:E86-E119.
  377. Chuang ML, Salton CL, O'Donnell CJ, Kissinger KV, Levy D, Manning WJ. Gender Differences in Detection of Concentric Left Ventricular Geometry by Magnetic Resonance Imaging. Society for Clinical Magnetic Resonance. 2002.
  378. Chuang ML, Salton CL, O'Donnell CJ, Kissinger KV, Levy D, Manning WJ. Criteria for Concentric Left Ventricular Remodeling As Determined Using Magnetic Resonance Imaging. Journal of the American College of Cardiology. 2002; 39(5):368A.
  379. Murabito JM, Nam B, D'Agostino RA, Lloyd-Jones DM, O'Donnell CJ, Wilson PW. Accuracy of reported family history of cardiovascular disease and risk factors: The Framingham Offspring Study. Journal of General Internal Medicine. 2002; 17(S1):116.
  380. O'Donnell CJ, MacRae CA. Genetics of Cardiovascular Disease. In American College of Cardiology Self-Assessment Program V (ACCSAP V) 2002. American College of Cardiology. 2002; (Chapter 19):8-12.
  381. Tofler GH, Massaro J, Muller JE, Levy D, Mittleman MA, Lipinska I, Feng D, O'Donnell C, Wilson PW, D'Agostine RB. Hemostatic Predictors of Cardiovascular Disease: Prospective Evaluation of the Framingham Offspring Study. Journal of the American College of Cardiology. 2002.
  382. Topol EJ, McCarthy J, Gabriel S, Moliterno DJ, Rogers WJ, Newby LK, Freedman M, Metivier J, Cannata R, O'Donnell CJ, Kottke-Marchant K, Murugesan G, Plow EF, Stenina O, Daley GQ. Single nucleotide polymorphisms in multiple novel thrombospondin genes may be associated with familial premature myocardial infarction. Circulation. 2001 Nov 27; 104(22):2641-4.
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  383. Vasan RS, Larson MG, Leip EP, Evans JC, O'Donnell CJ, Kannel WB, Levy D. Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med. 2001 Nov 1; 345(18):1291-7.
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  384. Singh JP, Larson MG, O'Donnell CJ, Levy D. Genetic factors contribute to the variance in frequency domain measures of heart rate variability. Auton Neurosci. 2001 Jul 20; 90(1-2):122-6.
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  385. Feng D, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Sutherland PA, Mittleman M, Muller JE, D'Agostino RB, Levy D, Tofler GH. Platelet glycoprotein IIIa Pl(a) polymorphism, fibrinogen, and platelet aggregability: The Framingham Heart Study. Circulation. 2001 Jul 10; 104(2):140-4.
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  386. Chan SK, Jaffer FA, Botnar RM, Kissinger KV, Goepfert L, Chuang ML, O'Donnell CJ, Levy D, Manning WJ. Scan Reproducibility of Magnetic Resonance Imaging Assessment of Aortic Atherosclerosis Burden. Journal of Cardiovascular Magnetic Resonance. 2001; 3(4):331-338.
  387. O'Donnell CJ, Larson MG, Feng D, Sutherland PA, Lindpaintner K, Myers RH, D'Agostino RA, Levy D, Tofler GH. Genetic and environmental contributions to platelet aggregation: the Framingham heart study. Circulation. 2001 Jun 26; 103(25):3051-6.
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  388. Kiel DP, Kauppila LI, Cupples LA, Hannan MT, O'Donnell CJ, Wilson PW. Bone loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart Study. Calcif Tissue Int. 2001 May; 68(5):271-6.
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  389. Lloyd-Jones DM, O'Donnell CJ, Silbershatz H, D'Agostino RB, Wilson PWF. Applicability of Cholesterol-Lowering Primary Prevention Studies to a General Population: The Framingham Heart Study. Archives in Internal Medicine. 2001; 161(7):949-954.
  390. Wilson PW, Kauppila LI, O'Donnell CJ, Kiel DP, Hannan M, Polak JM, Cupples LA. Abdominal aortic calcific deposits are an important predictor of vascular morbidity and mortality. Circulation. 2001 Mar 20; 103(11):1529-34.
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  391. Meigs JB, Larson MG, D'Agostino RB, Levy D, Clouse ME, Natan DM, Wilson PWF, O'Donnell CJ. Coronary Artery Calcification in Type 2 Diabetes and Insulin Resistance: ?The Framingham Offspring Study. Circulation. 2001; 103(9):1344.
  392. O'Donnell CJ, Benjamin EJ, Corey D, Newton-Cheh CH, Levy D, D'Agostino RB, Larson MG. The PR Interval is a Heritable Quantitative Trait with Evidence for Linkage to Chromosome 4 in a Genome-wide Scan: The Framingham Heart Study. Circulation. 2001; 103(9):1354.
  393. O'Donnell CJ, Larson MG, Kupka M, Manning WJ, Levy D, Clouse ME. Cumulative Effects of Cholesterol and Other Risk Factors on Coronary Artery Calcification in Men and Women: The Framingham Heart Study. Circulation. 2001; 103(9):1368.
  394. Walsh CR, Larson MG, Kupka MJ, Manning WJ, Clouse ME, O'Donnell CJ. Prevalence of Aortic Valve Calcium Detected by Electron Beam Computed Tomography and Association with Calcium Deposits in the Coronary Arteries and Aorta. Circulation. 2001; 104(17):II-537.
  395. Yang Q, Tofler GH, Cupples LA, Larson MG, Levy D, D'Agostino RB, O'Donnell CJ. A Genome-wide Scan for Circulating Levels of Fibrinogen in the Framingham Heart Study. American Journal of Human Genetics. 2001; 69(4).
  396. Feng D, Larson MG, Lindpaintner K, O'Donnell CJ, Mittleman M, Lipinska I, D'Agostino RB, Levy D, Tofler GH. Platelet GPIIIa PLA Polymorphism and Incident Cardiovascular Disease: The Framingham Heart Study. Journal of the American College of Cardiology. 2001; 37(2):304A.
  397. Hirschhorn JN, Altshuler D, Daly MJ, Lindgren CM, Burtt NP, Loomer M, Villapakkam A, Bolk S, O'Donnell CJ, Crews JD, Groop LC, Lander ES. Linkage Disequilibrium at PPARG and Other Genes Assessed with Dense Sets of SNPs. American Journal of Human Genetics. 2001; 69(4).
  398. O'Donnell CJ, Larson MG, Kupka MJ, Jaffer FA, Clouse ME, Levy D, Manning WJ. Subclinical Aortic Atherosclerosis Detected by MRI is Associated with Aortic and Coronary Calcificaiton and Carotid Intimal Medial LThickness in the Framingam Heart Study. Circulation. 2001; 104(17):II-375.
  399. Chuang ML, Salton CJ, Kissinger KV, Levy D, O'Donnell CJ, Manning WJ. M-Mode Errors in Determination of Left Ventricular Mass are Greater with Increasing Cavity Size and Wall thickness: an MRI Study. Journal of the American College of Cardiology. 2001; 837(2):392A.
  400. Morshedi-Meibodi A, Larson MG, Levy D, O'Donnell CJ, Vasan RS. Heart Rate Recovery after Exercise Testing and Risk of Coronary Disease in the Framingham Heart Study. Journal of the American College of Cardiology. 2001; 37(2):184A.
  401. Balady GJ, Larson MG, Vasan RS, O'Donnell CJ, Levy D. Does Treadmill Exercise Testing Predict Coronary Disease Risk in Asymptomatic Persons after Accounting for Framingham Risk Score?. Circulation. 2001; 104(17):II-376.
  402. Jeerakathil TJ, Wolf PA, Beiser A, Seshadri S, Case CS, O'Donnell CJ, Massaro JM, D'Agostino RB, DeCarli C. Framingham Coronary Risk Scores Predicts White Matter Hykperintensity and Total Cerebral Brain Volume: The Framingham Offspring Study. Neurology. 2001; 56((8) Supplement 3 ):A107-A108.
  403. O'Donnell CJ, Kiel DP, Hannan M, Wilson PWF. Do subclinical Arterial Calcific Deposits Predict Coronary Heart Disease Risk Beyond Risk Factor Profiles?. Circulation. 2001; 104(7):II-794.
  404. Chuang ML, Salton CJ, Kissinger KV, Levy D, O'Donnell CJ, Mannibng WJ. Relation Between Left Ventricular Sphericity and Errors in M-Mode Mass: Insights from Magnetic Resonance Imaging. Journal of the American College of Cardiology. 2001; 37(2):388A.
  405. Vasan RS, Larson MG, Levy D, Corey D, O'Donnell CJ, Benjamin EJ. Heritability and Genetic Linkage for Aortic Root and Left Atrial Size: The Framingham Heart Study. Circulation. 2001; 104(17):II-829.
  406. Jeerakathil TJ, Wolf PA, Beiser A, Seshadri S, Case CS, O'Donnell CJ, Massaro JM, D'Agostine RB, DeCarli C. Framingham Coronary Risk Scores Predicts White Matter Hyperintensity and Total Cerebral Brain Volume: The Framingham Offspring Study. Neurology. 2001; 56((8) Supplement 3):A107-A108.
  407. O'Donnell CJ, Larson MG, Kupka M, Manninbg WJ, Levy D, Clouse ME. Cumulative Effects of Cholesterol and Other Risk Factors on Coronary Artery Calcification in Men and Women: The Framingham Heart Center. Circulation. 2001; 103(9):1368.
  408. Walsh CR, Lloyd-Jones DM, Camargo CA, Giugliano RP, O'Donnell CJ. Clinical Trials of Unfractionated Heparin and Low-Molecular Weight Heparin in Addition to Aspirin for the Treatment of Unstable Angina Pectoris: Do the Results Apply to all Patients?. American Journal of Cardiology. 2000; 86(9):908-912.
  409. Lloyd-Jones DM, Evans JC, Larson MG, O'Donnell CJ, Roccella EJ, Levy D. Differential control of systolic and diastolic blood pressure : factors associated with lack of blood pressure control in the community. Hypertension. 2000 Oct; 36(4):594-9.
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  410. Levy D, DeStefano AL, Larson MG, O'Donnell CJ, Lifton RP, Gavras H, Cupples LA, Myers RH. Evidence for a gene influencing blood pressure on chromosome 17. Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the framingham heart study. Hypertension. 2000 Oct; 36(4):477-83.
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  411. Singh JP, Larson MG, O'Donnell CJ, Wilson PF, Tsuji H, Lloyd-Jones DM, Levy D. Association of hyperglycemia with reduced heart rate variability (The Framingham Heart Study). Am J Cardiol. 2000 Aug 1; 86(3):309-12.
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  412. O'Donnell CJ, Levy D. Weighing the evidence for infection as a risk factor for coronary heart disease. Curr Cardiol Rep. 2000 Jul; 2(4):280-7.
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  413. Giugliano RP, Lloyd-Jones DM, Camargo CA, Makary MA, O'Donnell CJ. Association of unstable angina guideline care with improved survival. Arch Intern Med. 2000 Jun 26; 160(12):1775-80.
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  414. Lloyd-Jones DM, Camargo CA, Giugliano RP, O'Donnell CJ. Effect of leukocytosis at initial examination on prognosis in patients with primary unstable angina. Am Heart J. 2000 May; 139(5):867-73.
    View in: PubMed
  415. Feng D, Tofler GH, Larson MG, O'Donnell CJ, Lipinska I, Schmitz C, Sutherland PA, Johnstone MT, Muller JE, D'Agostino RB, Levy D, Lindpaintner K. Factor VII gene polymorphism, factor VII levels, and prevalent cardiovascular disease: the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2000 Feb; 20(2):593-600.
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  416. DeStefano AL, Benjamin EJ, Larson MG, O'Donnell CJ, Vasan RS, Cupples LA, Myers RH, Levy D. Transformation of Left Ventricular(LV) Phenotypes in a Genome Scan in the NHLBI's Framingham Heart Study (FHS). Genome Epidemiology. 2000; 19:245.
  417. Larson MG, O'Donnell CJ, Cupples LA, Feng D, Caunt D, D'Agostine RB, Myers RH, Tofler GH. Evidence for a Gene on Chromosome 10 Influencing Factor VII Levels: A Genome-wide Scan in the Framingham Heart Study. Circulation. 2000; 102:II-259.
  418. Feng D, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Sutherland PA, D'Agostino RB, Levy D, Tofler GH. . The Fibrinogen Beta Hind III-148 Polymorphism and Prevalent Cardiovascular Disease: The Framingham Heart Study. Journal of the American College of Cardiology. 2000; 35(2):258A.
  419. Newton-Cheh CH, Larson MG, Benjamin EJ, Caunt D, D'Agostino RB, O'Donnell CJ. The QT Interval is a Heritable Quantitative Trait with Evidence for Linkage to Chromosome 3 in a Genome-wide Scan: The Framingham Heart Study. Circulation. 2000; 102:II-584.
  420. Kiel DP, Hannan MT, Cupples LA, Wilson PWF, Levy D, Clouse ME, Krueger-Lovy K, O'Donnell CJ. Low Bone Mineral Density is Associated with Coronary Artery Calcification. Journal of Bone Mineral Research. 2000; 15(Supplemental I):S160.
  421. DeStefano AL, Benjamin EJ, Larson MG, O'Donnell CJ, Vasan RS, Cupples LA, Myers RH, Levy D. Transformation of Left Ventricular (LV) Phenotypes in a Genome Scan in the NHLBI's Framingham Heart Study (FHS). Genome Epidemiology. 2000; 19:245.
  422. O'Donnell CJ, Larson MG, Cupples LA, Feng D, Caunt D, D'Agostino RB, Myers RH, Tofler GH. A Genome-wide Scan for Circulating Levels of Plasminogen Activator Inhibitor-1 and Tissue Plasminogen Activator in the Framingham Heart Study. Circulation. 2000; 102:II-257.
  423. O'Donnell CJ. Cardiovascular Genomics; Recent Progress, Current Challenges, Future Promise. Genome Biology. 2000; 1(Reports 409):1-409.3.
  424. Benjamin EJ, DeStefano AL, Larson MG, O'Donnell CJ, Vasan RS, Levy D. Genetic Linkage Analyses for Left Ventricular Mass Phenotypes in the Framingham Heart Study. Circulation. 2000; 102:II-860.
  425. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Caunt D, Levy D. Genome Scan Linkage Results for Heart Rate Variability: The Framingham Heart Study. Circulation. 2000; 102:II-684.
  426. Vasan RS, Larson MG, Evans JC, O'Donnell CJ, Levy D. High Normal Blood Pressure and Risk of Cardiovascular Disease: The Framingham Heart Study. Circulation. 2000; 101(6):715.
  427. Kinlay S, Burgess B, Rizoo R, Cordella N, Cabral V, O'Donnell C, Plutzky J. Conventional Coronary Risk Factors are more Frequent in Coronary Artery Bypass Recipients with Premature Atherosclerosis. Journal of the American College of Cardiology. 2000; 35(2):300A.
  428. O'Donnell CJ, Larson MG, Jaffer FA, Kissinger KV, Levy D, Manning WJ. Aortic Atherosclerosis Detected by MRI is Associated with Contemporaneous and Longitudinal Risk Factors: The Framingham Heart Study. Circulation. 2000; 102:II-836.
  429. Lloyd-Jones DM, Camargo CA, Giugliano RP, Walsh CR, Lager RA, O'Donnell CJ. Characteristics and Prognosis of Patients with Suspected Acute Myocardial Infarction and Elevated MB Relative Index but Noarmal Total Creatine Kinase. American Journal of Cardiology. 1999; 84(9):957-962.
  430. Lloyd-Jones DM, Evans JC, Larson MG, O'Donnell CJ, Wilson PW, Levy D. Cross-classification of JNC VI blood pressure stages and risk groups in the Framingham Heart Study. Arch Intern Med. 1999 Oct 11; 159(18):2206-12.
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  431. Lloyd-Jones DM, Evans JC, Larson MG, O'Donnell CJ, Levy D. Differential Impact of Systolic and Diastolic Blood Pressure Level on JNC-VI Staging. Hypertension. 1999; 34(3):381-385.
  432. O'Donnell CJ, Glynn RJ, Field TS, Averback R, Satterfield S, Friesenger GC, Taylor JO, Hennekens CH. Misclassification and Under-reporting of Recent Hospitalization for Acute Myocardial Infarction by Elderly Persons. Journal of Clinical Epidemiology. 1999; 52(8):745-752.
  433. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Evans JC, Levy D. Heritability of heart rate variability: the Framingham Heart Study. Circulation. 1999 May 4; 99(17):2251-4.
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  434. Singh JP, Larson MG, Manolio TA, O'Donnell CJ, Lauer M, Evans JC, Levy D. Blood pressure response during treadmill testing as a risk factor for new-onset hypertension. The Framingham heart study. Circulation. 1999 Apr 13; 99(14):1831-6.
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  435. Feng DL, Lindpaintner K, Larson MG, Rao VS, O'Donnell CJ, Sutherland PA, Silbershatz H, D'Agostino RB, Muller JE, Myers RH, Levy D, Tofler GH. Increased Platelet Aggregability Associated with Platelet GPIIIa PIA2 Polymorphism: The Framingham Offspring Study. Arteriosclerosis Thrombosis Vascular Biology. 1999; 19(4):1142-1147.
  436. Haider AW, Larson MG, O'Donnell CJ, Evans JC, Wilson PWFW, Levy D. The Association of Chronic Cough with Risk for Myocardial Infarction: The Framingham Heart Study. American Journal of Medicine. 1999; 106(3):279-284.
  437. Feng DL, Tofler G, Larson MG, O'Donnell CJ, Lipinska I, Sutherland PA, Levy D, Lindpaintner K. The Plasminogen Activator Inhibitor-1 Gene 4G/5G Polymorphism and Cardiovascular Disease: The Framingham Heart Study. Journal of the American College of Cardiology. 1999; 33(2):288A.
  438. Almond CS, Camargo CA, Lloyd-Jones DM, Giugliano RP, O'Donnell CJ. Determinants of Inaccurate ECD-9 Coding Among Patients with Unstable Angina. Academy of Emergency Medicine. 1999; 6:403.
  439. O'Donnell CJ, Kannell WB. Myocardial Infarction. In 50 Years of Discovery: Medical Milestones from the National Heart, Lung, and Blood Institute's Framingham Heart Study. Center for Bio-Medical Communication, Inc. 1999; 338-39.
  440. O'Donnell CJ, Cupples LA, Kiel D, Wilson PWF. Is Aortic Atherosclerosis Heritable? Familial Aggregation of Lumbar Aortic Calcification in the Framingham Heart Study. Journal of the American College of Cardiology. 1999; 6:403.
  441. Feng DL, Larson MG, Lindpaintner K, O'Donnell CJ, Lipinska I, Sutherland PA, Levy D, Tofler GH. Platelet GPIIIa Receptor PLa Polymorphism and Cardiovascular Disease: The Framingham Heart Study. Journal of the American College of Cardiology. 1999; 33(2):262A.
  442. Feng DL, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Sutherland PA, D'Agostino RB, Tofler GH. Platelet GPIIIa P1A2 Polymorphism, Fibrinogen Levels and Platelet Aggregability: The Framingham Heart Study. Circulation. 1999; 100(18):I-327.
  443. Hahn S, Jang IK, O'Donnell CJ. Antithrombotic Therapy for Acute Coronary Syndromes. Part II STE-MI. Journal of Critical Illness. 1999; 14:42-50.
  444. Wilson PWF, O'Donnell CJ, Kiel DP, Hannan M, Cupples LA. Lumbar Aortic Calcification is an Important Predictor of Vascular Morbidity and Mortality. Circulation. 1999; 99:1107.
  445. Lloyd-Jones DM, Evans JC, O'Donnell CJ, Roccella EJ, Levy D. Rates of Hypertension Control Based on Systolic Versus Diastolic Blood Pressure Level. Circulation. 1999; 100(18):I-35.
  446. Feng DL, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Sutherland PA, Levy D, Tofler GH. Interaction of beta fibrinogen gene polymorphism with diabetes mellitus: The Framingham Offspring Study. Journal of the American College of Cardiology. 1999; 33(2):312A.
  447. Lloyd-Jones DM, Camargo CA, Giugliano RP, O'Donnell CJ. Effect of Leukocytosis at Presentation on Prognosis in Unstable Angina. Academy of Emergency Medicine. 1999; 6:419.
  448. Jaffer FA, O'Donnell CJ, Chan SK, Kissinger KV, Levy D, Manning WJ. A New MRI Index of Aortic Atherosclerotic Burden in a Healthy Population. Circulation. 1999; 100(18):I-35.
  449. O'Donnell CJ, Silbershatz H, D'Agostino RA, Haider ?AW, Polak JF, Levy D, Wilson PWF. Relationship of C-Reactive Protein to Carotid Stenosis and Intimal Medial Thickness in the Framingham Heart Study. Circulation. 1999; 100(18):I-477.
  450. Myers RH, O'Donnell CJ. Genetics. In 50 Years of Discovery: Medical Milestones from the National Heart, Lung, and Blood Institute's Framingham Heart Study. Center for Bio-Medical Communication, Inc. 1999; 549-50.
  451. Haider AW, Wilson PWF, Larson MG, Sutherland P, Evans JC, O'Donnell CJ, Wolf PA, Michelson EL, Levy D. Chlamydia, H. Pyloria and Cytomegalovirus seropositivity and risk of cardiovascular disease: The Framingham Heart Study. Journal of the American College of Cardiology. 1999; 33(2):314A.
  452. Walsh CR, Camargo CA, Lloyd-Jones DM, Giugliano RP, O'Donnell CJ. Generalizability of Randomized Controlled Trials of Heparin and Aspirin to Consecutive Patients with Unstable Angina. Academy of Emergency Medicine. 1999; 6(`):424.
  453. Haider AW, WilsonPWF, Larson MG, O'Donnell CJ, Wolf PA, D'Agostine RA, Michelson EL, Levy D. Association of H Pylori, C Pneumoniae and Cytomegalovirus Seropositivity with Cardiovascular Disease in the Framingham Heart Study. Circulation. 1999; 100(18):I-521.
  454. Feng DL, Lindpaintner K, Larson MG, O'Donnell CJ (presenter), Lipinska I, Sutherland PA, Levy D, Tofler GH. The Contribution of Genetic (4G/5G polymorphism) and Environmental Factors to Plasminogen Activator Inhibitor-1 Antigen Levels: The Framingham Offspring Study. Journal of the American College of Cardiology. 1999; 33(2):312A.
  455. O'Donnell CJ, Kannel WB. Is there a racial predisposition to hypertension? Hypertension. 1998 Nov; 32(5):817-9.
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  456. O'Donnell CJ, Kannel WB. Cardiovascular risks of hypertension: Lessons from Observational Studies. Journal of Hypertension. 1998; 16((Suppl)):S3-S7.
  457. Singh JP, Larson MG, Tsuji H, Evans JC, O'Donnell CJ, Levy D. Reduced heart rate variability and new-onset hypertension: insights into pathogenesis of hypertension: the Framingham Heart Study. Hypertension. 1998 Aug; 32(2):293-7.
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  458. Himmelmann A, Hedner T, Hansson L, O'Donnell CJ, Levy D. Isolated systolic hypertension: an important cardiovascular risk factor. Blood Press. 1998 Jul; 7(4):197-207.
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  459. Giugliano RP, Camargo CA, Lloyd-Jones DM, Zagrodsky JD, Alexis JD, Eagle KA, Fuster V, O'Donnell CJ. Elderly patients receive less aggressive medical and invasive management of unstable angina: potential impact of practice guidelines. Arch Intern Med. 1998 May 25; 158(10):1113-20.
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  460. Lloyd-Jones DM, Camargo CA, Lapuerta P, Giugliano RP, O'Donnell CJ. Electrocardiographic and Clinical Predictors of Myocardial Infarction in Patients Presenting with Unstable Angina. American Journal of Cardiology. 1998; 81(10):1182-1186.
  461. O'Donnell CJ, Lindpaintner K, Larson MG, Rao VS, Ordovas JM, Schaefer EJ, Myers RH, Levy D. Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study. Circulation. 1998 May 12; 97(18):1766-72.
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  462. Albert CM, Hennekens CH, O'Donnell CJ, Ajani UA, Carey VJ, Willett WC, Ruskin JN, Manson JE. Fish consumption and risk of sudden cardiac death. JAMA. 1998 Jan 7; 279(1):23-8.
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  463. Singh J, Larson MG, O'Donnell CJ, Tsuji H, Levy D. Heritability of Heart Rate Variability: The Framingham Heart Study. Journal of the American College of Cardiology. 1998; 31(2):169A.
  464. Feng D, Lindpaintner K, Larson MG, O'Donnell CJ, Lilbershatz H, Lipinska I, Sutherland P, Muller JE, D'Agostino RB, Myers RH, Tofler GH. Factor VII Gene Polymorphism and Cardiovascular Disease: The Framingham Heart Study. Circulation. 1998; 98(17):I-458.
  465. Camargo CA, Lloyd-Jones DM, Giugliano RP, O'Donnell CJ. Characteristics and Prognosis of Patients with Acute Myocardial Infarction who Present with Atypical Symptoms. Annals of Emergency Medicine. 1998; 32:S2.
  466. Lloyd-Jones DM, Evans JC, Larson MG, O'Donnell CJ, Levy D. Systolic Versus Diastolic Blood Pressure Level as the Criterion for JNC-VI Blood Pressure Stage Classification: The Framingham Heart Study. Circulation. 1998; 98(17):I-518.
  467. O'Donnell CJ, Cupples LA, Kauppila LI, Kiel DP, Hannan MT, Polak JF, Wilson PWF. Heritability of Platelet Aggregation in the Framingham Heart Study. Circulation. 1998; 97:830.
  468. dLloyd Jones DM, O'Donnell CJ, Silbershatz H, D'Agostino, Jr. RB, Wilson PWF. Applicability of Cholesterol-Lowering Primary Prevention Studies to a General Population. Circulation. 1998; 98(17):I-46.
  469. Liel-Cohen N, Hunziker PR, O'Donnell CJ. Transthoracic Echocardiography Identifies Stroke Patients Free of Significant Thoracic Aortic Atherosclerosis. Circulation. 1998; 98(17):I-100.
  470. O'donnell CJ, Cupples LA, Kauppila LI, Kiel DP, Hannan MT, Polak JF, Wilson PWF. Risk Factors Associated with Progression of Lumbar Aortic Calcification. Circulation. 1998; 97.
  471. Feng D, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Schimitz C, Sutherland PA, Johnstone MT, Muller JE, Levy D, Tofler GH. Genetic and Environmental Influences on Factor VII Levels: The Framingham Heart Study. Circulation. 1998; 97:830.
  472. Giugliano RP, Camargo CA, Makary MA, Lloyd-Jones DM, O'Donnell CJ. Unstable Angina Guideline is Associated with Improved Outcome. Journal of the American College of Cardiology. 1998; 31(2):208A.
  473. Hahn S, Jang IK, O'Donnell CJ. Antithrombotic Therapy for Acute Coronary Syndromes, Part I: STE-MI. Journal of Critical Illness. 1998; 13:772-81.
  474. Singh JP, Larson MG, O'Donnell CJ, Tsuji H, Lloyd-Jones DM, Wilson P, Levy D. Hyperglycemia is Associated with Reduced Heart Rate Variability. Circulation. 1998; 98(17):I-647.
  475. Haider AW, Roubenoff R, Silbershatz H, D'Agostino R, Levy D, O'Donnell CJ. Inflamation, Cytokine Production and Atherosclerotic Cardiovascular Disease in the Elderly: The Framingham Heart Study. Circulation. 1998; 98(17):I-207.
  476. Gaziano JM, Hennekens CH, O'Donnell CJ, Breslow JL, Buring JE. Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation. 1997 Oct 21; 96(8):2520-5.
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  477. O'Donnell CJ, Ridker PM, Glynn RJ, Berger K, Ajani U, Manson JE, Hennekens CH. Hypertension and Borderline Isolated Systolic Blood Pressure Increase Risks of Cardiovascular Disease and Mortality in Male Physicians. Circulation. 1997; 95(5):1132-1137.
  478. O'Donnell CJ, Cupples LA, Kauppila LI, Polak JF, Levy D, Wilson PWF. Association of Subclinical Lumbar Aortic Calcification with Coronary Heart Disease Risk Factors. Canadian Journal of Cardiology. 1997; 13((Suppl B)):182B.
  479. Feng D, Tofler GH, Larson MG, O'Donnell CJ, Lipinska I, Schimitz C, Sutherland P, Muller JE, Levy D, Lindpaintner K. Genetic Determination of Factor VII Levels: The Framingham Offspring Study. Circulation. 1997; 96(8):I-2.
  480. Haider AW, Evans JC, Larson MG, O'Donnell CJ, Levy D. Chronic Bronchitis and Risk of Myocardial Infarction: The Framingham Heart Study. Circulation. 1997; 96(8):I-291.
  481. Singh JP, Larson MG, Tsuji H, Evans JC, O'Donnell CJ, Levy D. . Reduced Heart Rate Variability: A Risk Factor for New Onset Hypertension. Circulation. 1997; 96(8):I-406.
  482. O'donnell CJ, Larson MG, Feng DL, Lindpaintner K, Myers RH, Levy D, Tofler G. Heritability Assessment of Hemostatic Factors in the Framingham Heart Study. Circulation. 1997; 96(8):I-412.
  483. Lloyd-Jones DM, Camargo CA, Giugliano RP, Walsh CR, Lager RA, O'Donnell CJ. Clinical Characteristics and Prognosis of Patients with Normal Creatine Kinase but Elevated MB Isoenzyme Fraction. Circulation. 1997; 96(8):I-406.
  484. Feng D, Lindpaintner K, Larson MG, O'Donnell CJ, Lipinska I, Schimitz C, Sutherland P, Muller JE, Levy D, Tofler GH. Increased Platelet Aggregability Associated with Platelet GPIIIa PLA2 Polymorphism. Circulation. 1997; 96(8):I-333.
  485. O'Donnell CJ, Lindpaintner K, Larson MG, Ordovas JM, Myers RH, Levy D. The ACE Deletion-Insertion Polymorphism and Hypertension: An Association Analysis in the Framingham Heart Study. Journal of the American College of Cardiology. 1997; 29(2):84A.
  486. Singh JP, Larson MG, Manolio TA, Lauer MS, Evans JC, O'Donnell CJ, Levy D. Blood Pressure Response During Treadmill Exercise Testing as a Risk Factor for the Development of Hypertension. Circulation. 1997; 96(8):I-223.
  487. Giuliano RP, Camargo CA, Lloyd-Jones DM, Pasternak RC, O'Donnell CJ. Differences in Lipid Management Across the Spectrum of Acute Coronary Disease. Journal of the American College of Cardiology. 1997; 29(2):400A.
  488. Paul SD, O'Gara PT, Mahjoub ZA, DiSalvo TG, O'Donnell CJ, Newell JB, Villarreal-Levy G, Smith AJ, Kondo NI, Cararach M, Ferrer L, Eagle KA. Geriatric patients with acute myocardial infarction: Cardiac risk factor profiles, presentation, thrombolysis, coronary interventions, and prognosis. Am Heart J. 1996 Apr; 131(4):710-5.
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  489. O'Donnell CJ, Sleight P, Manson JE. Coronary Health Promotion. In Prevention of Myocardial Infarction. 1996.
  490. O'Donnell CJ, Manson JE. (Lipid-Lowering Agents) and (Oral Antihypertensive Agents). In Prevention of Myocardial Infarction. 1996.
  491. Camargo CA, Giugliano RP, Lloyd-Jones DM, Suratt B, Fuster V, O'donnell CJ. Are Guideline Recommendations Based on Randomized Trial Results Already Followed by Practicing Physicians?. Academic Emergency Medicine. 1996; 3:394.
  492. Albert CM, Manson JE, O'Donnell CJ, Ajani UA, Hennekens CH. Fish Consumption and the Risk of Sudden Death in the Physicians' Health Study. Circulation. 1996; 94(8):I-578.
  493. Giugliano RP, Camargo CA, Lloyd-Jones DM, Pasternak RC, O'Donnell CJ. Prevalence of Hypercholesterolemia and Lipid Management in Patients Presenting with Unstable Angina. Journal of the American College of Cardiology. 1996; 27(2):134A.
  494. Lloyd-Jones DM, Camargo CA, Giugliano RP, O'Donnell CJ. Electrocardiographic Predictors of Myocardial Infarction in Patients Presenting with Unstable Angina. Journal of the American College of Cardiology. 1996; 27(2):181A.
  495. O'Donnell CJ, Gillman MW, Gaziano MJ, Ajani U, Glynn RJ, Manson JE, Hennekens CH. Low to Moderate Levels of Alcohol Intake and Incidence of Hypertension. American Journal Epidemiology. 1996; 143(11):S50.
  496. O'Donnell CJ, Jonas MA, Hennekens CH. Aspirin augmentation of the efficacy of thrombolysis. Coron Artery Dis. 1995 Dec; 6(12):936-9.
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  497. Paul SD, Eagle KA, Guidry U, DiSalvo TG, Villarreal-Levy G, Smith AJ, O'Donnell CJ, Mahjoub ZA, Muluk V, Newell JB, et al. Do gender-based differences in presentation and management influence predictors of hospitalization costs and length of stay after an acute myocardial infarction? Am J Cardiol. 1995 Dec 1; 76(16):1122-5.
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  498. Hennekens CH, O'Donnell CJ, Ridker PM. Current and future perspectives on antithrombotic therapy of acute myocardial infarction. Eur Heart J. 1995 Jul; 16 Suppl D:2-9.
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  499. Hennekens CH, O'Donnell CJ, Ridker PM, Marder V. Thrombolytic Therapy in Acute Myocardial Infarction. Journal of the American College of Cardiology. 1995; 25((Suppl)):18S-22S.
  500. O'Donnell CJ, Ridker PM, Hebert P, Hennekens CH. Antithrombotic Therapy in Acute Myocardial Infarction. Journal of the American College of Cardiolgy. 1995; 25((7 Suppl)):23S-29S.
  501. O'Donnell CJ, Ridker PM, Hennekens CH. Thrombolytic therapy for acute myocardial infarction. Applying lessons from randomized trials to community practice. Ann Epidemiol. 1995 May; 5(3):250-2.
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  502. O'Donnell Cj, Ridker PM, Berger K, LaMotte F, Glynn RJ, Manson JE, Hennekens CH. Borderline Isolated Systolic Hypertension and Subsequent Risk of Cardiovascular Disease. Journal of the American College of Cardiology. 1995; 25:24A.
  503. Ridker PM, O'Donnell CJ, Hennekens CH. Direct Comparison of Aspirin plus Hirudin, Aspirin plus Heparin, and Aspirin Alone Among 12,000 Patients with Acute Myocardial Infarction not Receiving Thrombolysis: Rational and Design of the First American Study of Infarct Survival (ASIS-1). Journal of Thrombosis and Thrombolysis. 1995; 1(2):119-124.
  504. Camargo CA, Giugliano RP, Lloyd-Jones DM, Zagrodsky JD, Alexis JD, O'Donnell CJ. Circadian Variation in Unstable Angina and Non-ST Elevationb Myocardial Infarction: Effect of Cardiac Risk Factors and Medications. Circulation. 1995; 92(8):I-776.
  505. Giugliano RP, Camargom CA, Lloyd-Jones DM, Zagrodsky JD, Alexis JD, Fuster V, O'Donnell CJ. Would Guidelines Change Care of Elderly Patients with Unstable Angina?. Circulation. 1995; 92(8):I-19.
  506. O'Donnell CJ, Eagle KA, O'Gara PT, Paul SD. Eligibility for Thrombolytic Therapy is Limited Even with Expanded Criteria. Journal of the American College of Cardiology. 1995; 25:206A.
  507. Silver MT, Rose GA, Paul SD, O'Donnell CJ, O'Gara PT, Eagle KA. A clinical rule to predict preserved left ventricular ejection fraction in patients after myocardial infarction. Ann Intern Med. 1994 Nov 15; 121(10):750-6.
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  508. Ridker PM, O'Donnell CJ, Marder VJ, Hennekens CH. A Response to "Holding GUSTO up to theLight". Annals of Internal Medicine. 1994; 120(11):970.
  509. Berger K, Kase C, LaMotte F, O'Donnell CJ, Glynn RJ, Hennekens CH. Alcohol Consumption, Blood Pressure and Ischemic Stroke Among US Physicians. Circulation. 1994; 90(4):I-399.
  510. Villareal-Levy G, Smith AJC, Muluk VS, O'Donnell CJ, Newell J, Eagle KA, O'Gara PT. . Gender Differences in the Evaluation and Treatment of Patients with Myocardial Infarction. Circulation. 1994; 90(4):I-44.
  511. Silver MT, Rose GA, Paul SD, O'Donnell CJ, O'Gara PT, Eagle KA. Predicting Preserved Left Ventricular Ejection Fraction in Patients After Myocardial Infarction: Derivation and Validation of a Simple Clinical rule. Circulation. 1994; 90(4):I-44.
  512. Ridker PM, O'Donnell C, Marder VJ, Hennekens CH. Large-scale trials of thrombolytic therapy for acute myocardial infarction: GISSI-2, ISIS-3, and GUSTO-1. Ann Intern Med. 1993 Sep 15; 119(6):530-2.
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  513. O'Donnell CJ, Eagle KA. Preventive Cardiology in Women: The Evolving Role of Postmenopausal Estrogen Replacement in the Prevention of Cardiovascular Disease. The Female Patient. 1992.
  514. Coles NA, O'Donnell CJ(presenter), Muluk V, Fields T, Zisfein J, Barsky A, Hochstrasser B, Lipson R, Cothern M, Boucher C, Eagle K. Comparative Usefulness of Pre-Discharge Holter and Thallium for Post-MI Risk Stratification. Circulation. 1992; 86(4):I-139.
  515. Barsky AJ, Hochstrasser B, Coles A, Zisfein J, O'Donnell CJ, Eagle KA. Silent Myocardial Ischemia: Is the Person or the Event Silent?. Journal of the American Medical Association. 1990; 264(9):1132-1135.
  516. Fain JN, O'Donnell CJ, Mills I, Gárciá-Sáinz JA. Pertussis toxin reverses Gpp(NH)p inhibition of basal and forskolin activated adipocyte adenylate cyclase. Biochem Biophys Res Commun. 1983 Oct 31; 116(2):651-6.
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