Christopher Joseph O'Donnell, M.D.
|Title||Associate Clinical Professor of Medicine|
|Institution||Massachusetts General Hospital|
|Address||Massachusetts General Hospital|
Cardiac Unit- Pob3
55 Fruit St
Boston MA 02114
Available: 08/16/13, Expires: 08/29/14
Dr. O’Donnell conducts his research through his role as a National Heart, Lung and Blood Institute Senior Investigator in the Framingham Heart Study, in which detailed clinical phenotyping has been completed and genomewide scans of single nucleotide polymorphisms, exome/whole genome sequencing, transcriptome profiling and RNA sequencing has been completed. In collaboration with multiple other cohorts in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium and the Exome Sequencing Program, Dr. O'Donnell directs studies of the genetic determinants of subclinical atherosclerosis, clinical coronary heart disease, thrombosis and hemostasis and coronary heart disease risk factors. As such, he has been director and principal investigator of a large study of multidetector computed tomography imaging in two generations of family members to study coronary and aortic atherosclerosis. He is the FHS co-principal investigator on similar studies of cardiac magnetic resonance imaging and carotid ultrasound imaging in the Framingham Offspring. He is the principal investigator of detailed genetic studies of coronary and aortic calcification, carotid artery intimal medial thickness, hemostatic factor levels, and of aortic and left ventricular structure and function. He has overseen a study of the genetics of premature acute coronary syndromes at the Massachusetts General Hospital (MGH), one of the founding cohorts for the Myocardial Infarction Genetics (MIGen) Consortium and the Early MI project of the Exome Sequencing Project.
A number of student projects are possible using data from these various projects and programs.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Click the "See All" links for more information and interactive visualizations!
People who are also in this person's primary department.