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Keywords
Last Name
Institution

Ruth Margrit Ruprecht, M.D., PH.D.

TitleProfessor of Medicine
InstitutionDana-Farber Cancer Institute
DepartmentMedicine
AddressDana Farber Cancer Institute
Ofb 809
44 Binney St
Boston MA 02115
Phone617/632-3719
Fax617/632-3112

 Mentoring 
 completed student projects
Construction of a Replication-competent, Molecular Clone of a Pediatric HIV1 Clade C Isolate
Part Time, 02/01/02 - 06/15/02

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gupta S, Gach JS, Becerra JC, Phan TB, Pudney J, Moldoveanu Z, Joseph SB, Landucci G, Supnet MJ, Ping LH, Corti D, Moldt B, Hel Z, Lanzavecchia A, Ruprecht RM, Burton DR, Mestecky J, Anderson DJ, Forthal DN. The Neonatal Fc Receptor (FcRn) Enhances Human Immunodeficiency Virus Type 1 (HIV-1) Transcytosis across Epithelial Cells. PLoS Pathog. 2013 Nov; 9(11):e1003776.
    View in: PubMed
  2. Byrareddy SN, Ayash-Rashkovsky M, Kramer VG, Lee SJ, Correll M, Novembre FJ, Villinger F, Johnson WE, von Gegerfelt A, Felber BK, Ruprecht RM. Live Attenuated Rev-Independent Nef¯SIV Enhances Acquisition of Heterologous SIVsmE660 in Acutely Vaccinated Rhesus Macaques. PLoS One. 2013; 8(9):e75556.
    View in: PubMed
  3. Bachler BC, Humbert M, Lakhashe SK, Rasmussen RA, Ruprecht RM. Live-virus exposure of vaccine-protected macaques alters the anti-HIV-1 antibody repertoire in the absence of viremia. Retrovirology. 2013; 10:63.
    View in: PubMed
  4. Rao VR, Neogi U, Talboom JS, Padilla L, Rahman M, Fritz-French C, Gonzalez-Ramirez S, Verma A, Wood C, Ruprecht RM, Ranga U, Azim T, Joska J, Eugenin E, Shet A, Bimonte-Nelson H, Tyor WR, Prasad VR. Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence. Retrovirology. 2013; 10:61.
    View in: PubMed
  5. Watkins JD, Sholukh AM, Mukhtar MM, Siddappa NB, Lakhashe SK, Kim M, Reinherz EL, Gupta S, Forthal DN, Sattentau QJ, Villinger F, Corti D, Ruprecht RM. Anti-HIV IgA isotypes: differential virion capture and inhibition of transcytosis are linked to prevention of mucosal R5 SHIV transmission. AIDS. 2013 Jun 1; 27(9):F13-20.
    View in: PubMed
  6. Demberg T, Brocca-Cofano E, Kuate S, Aladi S, Vargas-Inchaustegui DA, Venzon D, Kalisz I, Kalyanaraman VS, Lee EM, Pal R, Dipasquale J, Ruprecht RM, Montefiori DC, Srivastava I, Barnett SW, Robert-Guroff M. Impact of antibody quality and anamnestic response on viremia control post-challenge in a combined Tat/Env vaccine regimen in rhesus macaques. Virology. 2013 Jun 5; 440(2):210-21.
    View in: PubMed
  7. Bachler BC, Humbert M, Palikuqi B, Siddappa NB, Lakhashe SK, Rasmussen RA, Ruprecht RM. Novel biopanning strategy to identify epitopes associated with vaccine protection. J Virol. 2013 Apr; 87(8):4403-16.
    View in: PubMed
  8. Zhang MY, Yuan T, Li J, Rosa Borges A, Watkins JD, Guenaga J, Yang Z, Wang Y, Wilson R, Li Y, Polonis VR, Pincus SH, Ruprecht RM, Dimitrov DS. Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41. PLoS One. 2012; 7(9):e44241.
    View in: PubMed
  9. Desimmie BA, Humbert M, Lescrinier E, Hendrix J, Vets S, Gijsbers R, Ruprecht RM, Dietrich U, Debyser Z, Christ F. Phage Display-directed Discovery of LEDGF/p75 Binding Cyclic Peptide Inhibitors of HIV Replication. Mol Ther. 2012 Nov; 20(11):2064-75.
    View in: PubMed
  10. Sholukh AM, Mukhtar MM, Humbert M, Essono SS, Watkins JD, Vyas HK, Shanmuganathan V, Hemashettar G, Kahn M, Hu SL, Montefiori DC, Polonis VR, Schur PH, Ruprecht RM. Isolation of monoclonal antibodies with predetermined conformational epitope specificity. PLoS One. 2012; 7(6):e38943.
    View in: PubMed
  11. Tso FY, Tully DC, Gonzalez S, Quince C, Ho O, Polacino P, Ruprecht RM, Hu SL, Wood C. Dynamics of envelope evolution in clade C SHIV-infected pig-tailed macaques during disease progression analyzed by ultra-deep pyrosequencing. PLoS One. 2012; 7(3):e32827.
    View in: PubMed
  12. Rasmussen RA, Siddappa NB, Lakhashe SK, Watkins J, Villinger F, Ibegbu C, Florese RH, Robert-Guroff M, Montefiori DC, Forthal DN, O'Connor D, Ruprecht RM. High-level, lasting antiviral immunity induced by a bimodal AIDS vaccine and boosted by live-virus exposure: prevention of viremia. AIDS. 2012 Jan 14; 26(2):149-55.
    View in: PubMed
  13. Lakhashe SK, Silvestri G, Ruprecht RM. No acquisition: a new ambition for HIV vaccine development? Curr Opin Virol. 2011 Oct; 1(4):246-53.
    View in: PubMed
  14. Watkins JD, Diaz-Rodriguez J, Siddappa NB, Corti D, Ruprecht RM. Efficiency of neutralizing antibodies targeting the CD4-binding site: influence of conformational masking by the V2 loop in R5-tropic clade C simian-human immunodeficiency virus. J Virol. 2011 Dec; 85(23):12811-4.
    View in: PubMed
  15. Liu Q, Li Y, Yang G, Dai J, Ruprecht RM, Shao Y. Molecularly cloned SHIV-CN97001: a replication-competent, R5 simian/human immunodeficiency virus containing env of a primary Chinese HIV-1 clade C isolate. J Med Primatol. 2011 Dec; 40(6):427-36.
    View in: PubMed
  16. Siddappa NB, Hemashettar G, Shanmuganathan V, Semenya AA, Sweeney ED, Paul KS, Lee SJ, Secor WE, Ruprecht RM. Schistosoma mansoni enhances host susceptibility to mucosal but not intravenous challenge by R5 Clade C SHIV. PLoS Negl Trop Dis. 2011 Aug; 5(8):e1270.
    View in: PubMed
  17. Lakhashe SK, Wang W, Siddappa NB, Hemashettar G, Polacino P, Hu SL, Villinger F, Else JG, Novembre FJ, Yoon JK, Lee SJ, Montefiori DC, Ruprecht RM, Rasmussen RA. Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection. PLoS One. 2011; 6(7):e22010.
    View in: PubMed
  18. Lakhashe SK, Velu V, Sciaranghella G, Siddappa NB, Dipasquale JM, Hemashettar G, Yoon JK, Rasmussen RA, Yang F, Lee SJ, Montefiori DC, Novembre FJ, Villinger F, Amara RR, Kahn M, Hu SL, Li S, Li Z, Frankel FR, Robert-Guroff M, Johnson WE, Lieberman J, Ruprecht RM. Prime-boost vaccination with heterologous live vectors encoding SIV gag and multimeric HIV-1 gp160 protein: efficacy against repeated mucosal R5 clade C SHIV challenges. Vaccine. 2011 Aug 5; 29(34):5611-22.
    View in: PubMed
  19. Santosuosso M, Righi E, Hill ED, Leblanc PR, Kodish B, Mylvaganam HN, Siddappa NB, Stevceva L, Hu SL, Ghebremichael M, Chenine AL, Hovav AH, Ruprecht RM, Poznansky MC. R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes. PLoS One. 2011; 6(4):e18465.
    View in: PubMed
  20. Watkins JD, Siddappa NB, Lakhashe SK, Humbert M, Sholukh A, Hemashettar G, Wong YL, Yoon JK, Wang W, Novembre FJ, Villinger F, Ibegbu C, Patel K, Corti D, Agatic G, Vanzetta F, Bianchi S, Heeney JL, Sallusto F, Lanzavecchia A, Ruprecht RM. An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV. PLoS One. 2011; 6(3):e18207.
    View in: PubMed
  21. Whitney JB, Mirshahidi S, Lim SY, Goins L, Ibegbu CC, Anderson DC, Raybourne RB, Frankel FR, Lieberman J, Ruprecht RM. Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV. J Immune Based Ther Vaccines. 2011; 9:2.
    View in: PubMed
  22. Yin J, Dai A, Lecureux J, Arango T, Kutzler MA, Yan J, Lewis MG, Khan A, Sardesai NY, Montefiore D, Ruprecht R, Weiner DB, Boyer JD. High antibody and cellular responses induced to HIV-1 clade C envelope following DNA vaccines delivered by electroporation. Vaccine. 2011 Sep 9; 29(39):6763-70.
    View in: PubMed
  23. Sciaranghella G, Lakhashe SK, Ayash-Rashkovsky M, Mirshahidi S, Siddappa NB, Novembre FJ, Velu V, Amara RR, Zhou C, Li S, Li Z, Frankel FR, Ruprecht RM. A live attenuated Listeria monocytogenes vaccine vector expressing SIV Gag is safe and immunogenic in macaques and can be administered repeatedly. Vaccine. 2011 Jan 10; 29(3):476-86.
    View in: PubMed
  24. Siddappa NB, Hemashettar G, Wong YL, Lakhashe S, Rasmussen RA, Watkins JD, Novembre FJ, Villinger F, Else JG, Montefiori DC, Ruprecht RM. Development of a tier 1 R5 clade C simian-human immunodeficiency virus as a tool to test neutralizing antibody-based immunoprophylaxis. J Med Primatol. 2011 Apr; 40(2):120-8.
    View in: PubMed
  25. García A, Siddappa NB, Li Q, Haase AT, Paul K, Stroud F, Zhang X, Fountain JA, Villinger F, Novembre FJ, Else JG, Evan Secor W, Ruprecht RM. AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4. J Med Primatol. 2010 Oct; 39(5):356-60.
    View in: PubMed
  26. Siddappa NB, Watkins JD, Wassermann KJ, Song R, Wang W, Kramer VG, Lakhashe S, Santosuosso M, Poznansky MC, Novembre FJ, Villinger F, Else JG, Montefiori DC, Rasmussen RA, Ruprecht RM. R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models. PLoS One. 2010; 5(7):e11689.
    View in: PubMed
  27. Rasmussen RA, Lakhashe SK, Ruprecht RM. Bimodal AIDS vaccine approach: induction of cellular as well as humoral immunity can protect from systemic infection. Vaccine. 2010 May 26; 28 Suppl 2:B25-31.
    View in: PubMed
  28. Chenine AL, Siddappa NB, Kramer VG, Sciaranghella G, Rasmussen RA, Lee SJ, Santosuosso M, Poznansky MC, Velu V, Amara RR, Souder C, Anderson DC, Villinger F, Else JG, Novembre FJ, Strobert E, O'Neil SP, Secor WE, Ruprecht RM. Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes. J Infect Dis. 2010 Apr 15; 201(8):1155-63.
    View in: PubMed
  29. Tso FY, Hoffmann FG, Tully DC, Lemey P, Rasmussen RA, Zhang H, Ruprecht RM, Wood C. A comparative study of HIV-1 clade C env evolution in a Zambian infant with an infected rhesus macaque during disease progression. AIDS. 2009 Sep 10; 23(14):1817-28.
    View in: PubMed
  30. Ho O, Larsen K, Polacino P, Li Y, Anderson D, Song R, Ruprecht RM, Hu SL. Pathogenic infection of Macaca nemestrina with a CCR5-tropic subtype-C simian-human immunodeficiency virus. Retrovirology. 2009; 6:65.
    View in: PubMed
  31. Van Rhijn I, Young DC, De Jong A, Vazquez J, Cheng TY, Talekar R, Barral DC, Barral D, León L, Brenner MB, Katz JT, Riese R, Ruprecht RM, O'Connor PB, Costello CE, Porcelli SA, Briken V, Moody DB. CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. J Exp Med. 2009 Jun 8; 206(6):1409-22.
    View in: PubMed
  32. Popov S, Mirshahidi S, Essono S, Song R, Wang X, Ruprecht RM. Generation of recombinant vaccinia viruses via green fluorescent protein selection. DNA Cell Biol. 2009 Mar; 28(3):103-8.
    View in: PubMed
  33. Mirshahidi S, Kramer VG, Whitney JB, Essono S, Lee S, Dranoff G, Anderson KS, Ruprecht RM. Overlapping synthetic peptides encoding TPD52 as breast cancer vaccine in mice: prolonged survival. Vaccine. 2009 Mar 13; 27(12):1825-33.
    View in: PubMed
  34. Ruprecht RM. Passive immunization with human neutralizing monoclonal antibodies against HIV-1 in macaque models: experimental approaches. Methods Mol Biol. 2009; 525:559-66, xiv.
    View in: PubMed
  35. Humbert M, Rasmussen RA, Ong H, Kaiser FM, Hu SL, Ruprecht RM. Inducing cross-clade neutralizing antibodies against HIV-1 by immunofocusing. PLoS One. 2008; 3(12):e3937.
    View in: PubMed
  36. Siddappa NB, Song R, Kramer VG, Chenine AL, Velu V, Ong H, Rasmussen RA, Grisson RD, Wood C, Zhang H, Kankasa C, Amara RR, Else JG, Novembre FJ, Montefiori DC, Ruprecht RM. Neutralization-sensitive R5-tropic simian-human immunodeficiency virus SHIV-2873Nip, which carries env isolated from an infant with a recent HIV clade C infection. J Virol. 2009 Feb; 83(3):1422-32.
    View in: PubMed
  37. Humbert M, Rasmussen RA, Song R, Ong H, Sharma P, Chenine AL, Kramer VG, Siddappa NB, Xu W, Else JG, Novembre FJ, Strobert E, O'Neil SP, Ruprecht RM. SHIV-1157i and passaged progeny viruses encoding R5 HIV-1 clade C env cause AIDS in rhesus monkeys. Retrovirology. 2008; 5:94.
    View in: PubMed
  38. Chenine AL, Shai-Kobiler E, Steele LN, Ong H, Augostini P, Song R, Lee SJ, Autissier P, Ruprecht RM, Secor WE. Acute Schistosoma mansoni infection increases susceptibility to systemic SHIV clade C infection in rhesus macaques after mucosal virus exposure. PLoS Negl Trop Dis. 2008; 2(7):e265.
    View in: PubMed
  39. Zhang MY, Vu BK, Choudhary A, Lu H, Humbert M, Ong H, Alam M, Ruprecht RM, Quinnan G, Jiang S, Montefiori DC, Mascola JR, Broder CC, Haynes BF, Dimitrov DS. Cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody that recognizes a novel conformational epitope on gp41 and lacks reactivity against self-antigens. J Virol. 2008 Jul; 82(14):6869-79.
    View in: PubMed
  40. Polonis VR, Brown BK, Rosa Borges A, Zolla-Pazner S, Dimitrov DS, Zhang MY, Barnett SW, Ruprecht RM, Scarlatti G, Fenyö EM, Montefiori DC, McCutchan FE, Michael NL. Recent advances in the characterization of HIV-1 neutralization assays for standardized evaluation of the antibody response to infection and vaccination. Virology. 2008 Jun 5; 375(2):315-20.
    View in: PubMed
  41. Kramer VG, Siddappa NB, Ruprecht RM. Passive immunization as tool to identify protective HIV-1 Env epitopes. Curr HIV Res. 2007 Nov; 5(6):642-55.
    View in: PubMed
  42. Rasmussen RA, Ong H, Song R, Chenine AL, Ayash-Rashkovsky M, Hu SL, Polacino P, Else JG, Novembre FJ, Ruprecht RM. Efficacy of a multigenic protein vaccine containing multimeric HIV gp160 against heterologous SHIV clade C challenges. AIDS. 2007 Sep 12; 21(14):1841-8.
    View in: PubMed
  43. Jiang S, Rasmussen RA, Nolan KM, Frankel FR, Lieberman J, McClure HM, Williams KM, Babu US, Raybourne RB, Strobert E, Ruprecht RM. Live attenuated Listeria monocytogenes expressing HIV Gag: immunogenicity in rhesus monkeys. Vaccine. 2007 Oct 16; 25(42):7470-9.
    View in: PubMed
  44. Ayash-Rashkovsky M, Chenine AL, Steele LN, Lee SJ, Song R, Ong H, Rasmussen RA, Hofmann-Lehmann R, Else JG, Augostini P, McClure HM, Secor WE, Ruprecht RM. Coinfection with Schistosoma mansoni reactivates viremia in rhesus macaques with chronic simian-human immunodeficiency virus clade C infection. Infect Immun. 2007 Apr; 75(4):1751-6.
    View in: PubMed
  45. Gruber A, Chalmers AS, Rasmussen RA, Ong H, Popov S, Andersen J, Hu SL, Ruprecht RM. Dendritic cell-based vaccine strategy against human immunodeficiency virus clade C: skewing the immune response toward a helper T cell type 2 profile. Viral Immunol. 2007; 20(1):160-9.
    View in: PubMed
  46. Vlasak J, Ruprecht RM. AIDS vaccine development and challenge viruses: getting real. AIDS. 2006 Nov 14; 20(17):2135-40.
    View in: PubMed
  47. Zhang H, Hoffmann F, He J, He X, Kankasa C, West JT, Mitchell CD, Ruprecht RM, Orti G, Wood C. Characterization of HIV-1 subtype C envelope glycoproteins from perinatally infected children with different courses of disease. Retrovirology. 2006; 3:73.
    View in: PubMed
  48. Ferrantelli F, Buckley KA, Rasmussen RA, Chalmers A, Wang T, Li PL, Williams AL, Hofmann-Lehmann R, Montefiori DC, Cavacini LA, Katinger H, Stiegler G, Anderson DC, McClure HM, Ruprecht RM. Time dependence of protective post-exposure prophylaxis with human monoclonal antibodies against pathogenic SHIV challenge in newborn macaques. Virology. 2007 Feb 5; 358(1):69-78.
    View in: PubMed
  49. Song RJ, Chenine AL, Rasmussen RA, Ruprecht CR, Mirshahidi S, Grisson RD, Xu W, Whitney JB, Goins LM, Ong H, Li PL, Shai-Kobiler E, Wang T, McCann CM, Zhang H, Wood C, Kankasa C, Secor WE, McClure HM, Strobert E, Else JG, Ruprecht RM. Molecularly cloned SHIV-1157ipd3N4: a highly replication- competent, mucosally transmissible R5 simian-human immunodeficiency virus encoding HIV clade C Env. J Virol. 2006 Sep; 80(17):8729-38.
    View in: PubMed
  50. Jiang S, Song R, Popov S, Mirshahidi S, Ruprecht RM. Overlapping synthetic peptides as vaccines. Vaccine. 2006 Sep 11; 24(37-39):6356-65.
    View in: PubMed
  51. von Gegerfelt AS, Alicea C, Valentin A, Morrow M, van Rompay KK, Ayash-Rashkovsky M, Markham P, Else JG, Marthas ML, Pavlakis GN, Ruprecht RM, Felber BK. Long lasting control and lack of pathogenicity of the attenuated Rev-independent SIV in rhesus macaques. AIDS Res Hum Retroviruses. 2006 Jun; 22(6):516-28.
    View in: PubMed
  52. Rasmussen RA, Ong H, Kittel C, Ruprecht CR, Ferrantelli F, Hu SL, Polacino P, Policano P, McKenna J, Moon J, Travis B, Ruprecht RM. DNA prime/protein boost immunization against HIV clade C: safety and immunogenicity in mice. Vaccine. 2006 Mar 20; 24(13):2324-32.
    View in: PubMed
  53. Zhang H, Hoffmann F, He J, He X, Kankasa C, Ruprecht R, West JT, Orti G, Wood C. Evolution of subtype C HIV-1 Env in a slowly progressing Zambian infant. Retrovirology. 2005; 2:67.
    View in: PubMed
  54. Chenine AL, Buckley KA, Li PL, Rasmussen RA, Ong H, Jiang S, Wang T, Augostini P, Secor WE, Ruprecht RM. Schistosoma mansoni infection promotes SHIV clade C replication in rhesus macaques. AIDS. 2005 Nov 4; 19(16):1793-7.
    View in: PubMed
  55. Schmitz JE, Johnson RP, McClure HM, Manson KH, Wyand MS, Kuroda MJ, Lifton MA, Khunkhun RS, McEvers KJ, Gillis J, Piatak M, Lifson JD, Grosschupff G, Racz P, Tenner-Racz K, Rieber EP, Kuus-Reichel K, Gelman RS, Letvin NL, Montefiori DC, Ruprecht RM, Desrosiers RC, Reimann KA. Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques. J Virol. 2005 Jul; 79(13):8131-41.
    View in: PubMed
  56. Mc Cann CM, Song RJ, Ruprecht RM. Antibodies: can they protect against HIV infection? Curr Drug Targets Infect Disord. 2005 Jun; 5(2):95-111.
    View in: PubMed
  57. Cavacini LA, Duval M, Patil A, Wood C, Mayer KH, Ruprecht RM, Posner MR. Dichotomy in cross-clade reactivity and neutralization by HIV-1 sera: Implications for active and passive immunotherapy. J Med Virol. 2005 Jun; 76(2):146-52.
    View in: PubMed
  58. Wu Y, Hong K, Chenine AL, Whitney JB, Xu W, Chen Q, Geng Y, Ruprecht RM, Shao Y. Molecular cloning and in vitro evaluation of an infectious simian-human immunodeficiency virus containing env of a primary Chinese HIV-1 subtype C isolate. J Med Primatol. 2005 Apr; 34(2):101-7.
    View in: PubMed
  59. Li PL, Wang T, Buckley KA, Chenine AL, Popov S, Ruprecht RM. Phosphorylation of HIV Nef by cAMP-dependent protein kinase. Virology. 2005 Jan 20; 331(2):367-74.
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  60. Chenine AL, Ferrantelli F, Hofmann-Lehmann R, Vangel MG, McClure HM, Ruprecht RM. Older rhesus macaque infants are more susceptible to oral infection with simian-human immunodeficiency virus 89.6P than neonates. J Virol. 2005 Jan; 79(2):1333-6.
    View in: PubMed
  61. Popov S, Chenine AL, Gruber A, Li PL, Ruprecht RM. Long-term productive human immunodeficiency virus infection of CD1a-sorted myeloid dendritic cells. J Virol. 2005 Jan; 79(1):602-8.
    View in: PubMed
  62. Grisson RD, Chenine AL, Yeh LY, He J, Wood C, Bhat GJ, Xu W, Kankasa C, Ruprecht RM. Infectious molecular clone of a recently transmitted pediatric human immunodeficiency virus clade C isolate from Africa: evidence of intraclade recombination. J Virol. 2004 Dec; 78(24):14066-9.
    View in: PubMed
  63. Kim TG, Gruber A, Ruprecht RM, Langridge WH. Synthesis and assembly of SIVmac Gag p27 capsid protein cholera toxin B subunit fusion protein in transgenic potato. Mol Biotechnol. 2004 Sep; 28(1):33-40.
    View in: PubMed
  64. Kim TG, Ruprecht R, Langridge WH. SIVmac Gag p27 capsid protein gene expression in potato. Protein Expr Purif. 2004 Aug; 36(2):312-7.
    View in: PubMed
  65. Kim TG, Ruprecht R, Langridge WH. Synthesis and assembly of a cholera toxin B subunit SHIV 89.6p Tat fusion protein in transgenic potato. Protein Expr Purif. 2004 Jun; 35(2):313-9.
    View in: PubMed
  66. Ferrantelli F, Rasmussen RA, Buckley KA, Li PL, Wang T, Montefiori DC, Katinger H, Stiegler G, Anderson DC, McClure HM, Ruprecht RM. Complete protection of neonatal rhesus macaques against oral exposure to pathogenic simian-human immunodeficiency virus by human anti-HIV monoclonal antibodies. J Infect Dis. 2004 Jun 15; 189(12):2167-73.
    View in: PubMed
  67. Safrit JT, Ruprecht R, Ferrantelli F, Xu W, Kitabwalla M, Van Rompay K, Marthas M, Haigwood N, Mascola JR, Luzuriaga K, Jones SA, Mathieson BJ, Newell ML. Immunoprophylaxis to prevent mother-to-child transmission of HIV-1. J Acquir Immune Defic Syndr. 2004 Feb 1; 35(2):169-77.
    View in: PubMed
  68. Whitney JB, Ruprecht RM. Live attenuated HIV vaccines: pitfalls and prospects. Curr Opin Infect Dis. 2004 Feb; 17(1):17-26.
    View in: PubMed
  69. Ferrantelli F, Kitabwalla M, Rasmussen RA, Cao C, Chou TC, Katinger H, Stiegler G, Cavacini LA, Bai Y, Cotropia J, Ugen KE, Ruprecht RM. Potent cross-group neutralization of primary human immunodeficiency virus isolates with monoclonal antibodies--implications for acquired immunodeficiency syndrome vaccine. J Infect Dis. 2004 Jan 1; 189(1):71-4.
    View in: PubMed
  70. Buckley KA, Li PL, Khimani AH, Hofmann-Lehmann R, Liska V, Anderson DC, McClure HM, Ruprecht RM. Convergent evolution of SIV env after independent inoculation of rhesus macaques with infectious proviral DNA. Virology. 2003 Aug 1; 312(2):470-80.
    View in: PubMed
  71. Ruprecht RM, Ferrantelli F, Kitabwalla M, Xu W, McClure HM. Antibody protection: passive immunization of neonates against oral AIDS virus challenge. Vaccine. 2003 Jul 28; 21(24):3370-3.
    View in: PubMed
  72. Pion M, Sanchez G, Liska V, Bettendroffer L, Candotti D, Chenine AL, Gondois-Rey F, Tamalet C, Vigne R, Ruprecht RM, Agut H, Hirsch I. Truncated forms of human and simian immunodeficiency virus in infected individuals and rhesus macaques are unique or rare quasispecies. Virology. 2003 Jun 20; 311(1):157-68.
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  73. Ferrantelli F, Hofmann-Lehmann R, Rasmussen RA, Wang T, Xu W, Li PL, Montefiori DC, Cavacini LA, Katinger H, Stiegler G, Anderson DC, McClure HM, Ruprecht RM. Post-exposure prophylaxis with human monoclonal antibodies prevented SHIV89.6P infection or disease in neonatal macaques. AIDS. 2003 Feb 14; 17(3):301-9.
    View in: PubMed
  74. Kitabwalla M, Ferrantelli F, Wang T, Chalmers A, Katinger H, Stiegler G, Cavacini LA, Chou TC, Ruprecht RM. Primary African HIV clade A and D isolates: effective cross-clade neutralization with a quadruple combination of human monoclonal antibodies raised against clade B. AIDS Res Hum Retroviruses. 2003 Feb; 19(2):125-31.
    View in: PubMed
  75. Hofmann-Lehmann R, Vlasak J, Williams AL, Chenine AL, McClure HM, Anderson DC, O'Neil S, Ruprecht RM. Live attenuated, nef-deleted SIV is pathogenic in most adult macaques after prolonged observation. AIDS. 2003 Jan 24; 17(2):157-66.
    View in: PubMed
  76. Ferrantelli F, Rasmussen RA, Hofmann-Lehmann R, Xu W, McClure HM, Ruprecht RM. Do not underestimate the power of antibodies--lessons from adoptive transfer of antibodies against HIV. Vaccine. 2002 Dec 19; 20 Suppl 4:A61-5.
    View in: PubMed
  77. Gruber A, Chalmers AS, Popov S, Ruprecht RM. Functional aspects of binding of monoclonal antibody DCN46 to DC-SIGN on dendritic cells. Immunol Lett. 2002 Nov 1; 84(2):103-8.
    View in: PubMed
  78. Kitabwalla M, Ruprecht RM. RNA interference--a new weapon against HIV and beyond. N Engl J Med. 2002 Oct 24; 347(17):1364-7.
    View in: PubMed
  79. Ferrantelli F, Ruprecht RM. Neutralizing antibodies against HIV -- back in the major leagues? Curr Opin Immunol. 2002 Aug; 14(4):495-502.
    View in: PubMed
  80. Hofmann-Lehmann R, Williams AL, Swenerton RK, Li PL, Rasmussen RA, Chenine AL, McClure HM, Ruprecht RM. Quantitation of simian cytokine and beta-chemokine mRNAs, using real-time reverse transcriptase-polymerase chain reaction: variations in expression during chronic primate lentivirus infection. AIDS Res Hum Retroviruses. 2002 Jun 10; 18(9):627-39.
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  81. Hofmann-Lehmann R, Vlasak J, Rasmussen RA, Jiang S, Li PL, Baba TW, Montefiori DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Cavacini LA, Posner MR, Ruprecht RM. Postnatal pre- and postexposure passive immunization strategies: protection of neonatal macaques against oral simian-human immunodeficiency virus challenge. J Med Primatol. 2002 Jun; 31(3):109-19.
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  82. Xu W, Zhang Y, Yeh LY, Ruprecht CR, Wong-Staal F, McFadden BA, Reddy TR, Ruprecht RM. One-step, highly efficient site-directed mutagenesis by toxic protein selection. Biotechniques. 2002 Jun; 32(6):1266-8, 1270.
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  83. Xu W, Hofmann-Lehmann R, McClure HM, Ruprecht RM. Passive immunization with human neutralizing monoclonal antibodies: correlates of protective immunity against HIV. Vaccine. 2002 May 6; 20(15):1956-60.
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  84. Hofmann-Lehmann R, Vlasak J, Chenine AL, Li PL, Baba TW, Montefiori DC, McClure HM, Anderson DC, Ruprecht RM. Molecular evolution of human immunodeficiency virus env in humans and monkeys: similar patterns occur during natural disease progression or rapid virus passage. J Virol. 2002 May; 76(10):5278-84.
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  85. Rasmussen RA, Hofmann-Lehmann R, Li PL, Vlasak J, Schmitz JE, Reimann KA, Kuroda MJ, Letvin NL, Montefiori DC, McClure HM, Ruprecht RM. Neutralizing antibodies as a potential secondary protective mechanism during chronic SHIV infection in CD8+ T-cell-depleted macaques. AIDS. 2002 Apr 12; 16(6):829-38.
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  86. Rasmussen RA, Hofmann-Lehman R, Montefiori DC, Li PL, Liska V, Vlasak J, Baba TW, Schmitz JE, Kuroda MJ, Robinson HL, McClure HM, Lu S, Hu SL, Rizvi TA, Ruprecht RM. DNA prime/protein boost vaccine strategy in neonatal macaques against simian human immunodeficiency virus. J Med Primatol. 2002 Feb; 31(1):40-60.
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  87. von Gegerfelt AS, Liska V, Li PL, McClure HM, Horie K, Nappi F, Montefiori DC, Pavlakis GN, Marthas ML, Ruprecht RM, Felber BK. Rev-independent simian immunodeficiency virus strains are nonpathogenic in neonatal macaques. J Virol. 2002 Jan; 76(1):96-104.
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  88. Rasmussen RA, Montefiori DC, Robinson HL, McClure HM, Ruprecht RM. Heterologous neutralizing antibody induction in a simian-human immunodeficiency virus primate model: lack of original antigenic sin. J Infect Dis. 2001 Dec 15; 184(12):1603-7.
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  89. Pion M, Liska V, Chenine AL, Hofmann-Lehmann R, Vlasak J, Gondois-Rey F, Ruprecht RM, Hirsch I. Extensively deleted simian immunodeficiency virus (SIV) DNA in macaques inoculated with supercoiled plasmid DNA encoding full-length SIVmac239. Virology. 2001 Oct 10; 289(1):103-13.
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  90. Ruprecht RM, Hofmann-Lehmann R, Smith-Franklin BA, Rasmussen RA, Liska V, Vlasak J, Xu W, Baba TW, Chenine AL, Cavacini LA, Posner MR, Katinger H, Stiegler G, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Montefiori DC, McClure HM. Protection of neonatal macaques against experimental SHIV infection by human neutralizing monoclonal antibodies. Transfus Clin Biol. 2001 Aug; 8(4):350-8.
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  91. Hofmann-Lehmann R, Rasmussen RA, Vlasak J, Smith BA, Baba TW, Liska V, Montefiori DC, McClure HM, Anderson DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Posner MR, Cavacini LA, Chou TC, Ruprecht RM. Passive immunization against oral AIDS virus transmission: an approach to prevent mother-to-infant HIV-1 transmission? J Med Primatol. 2001 Aug; 30(4):190-6.
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  92. Hofmann-Lehmann R, Vlasak J, Rasmussen RA, Smith BA, Baba TW, Liska V, Ferrantelli F, Montefiori DC, McClure HM, Anderson DC, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Katinger H, Stiegler G, Cavacini LA, Posner MR, Chou TC, Andersen J, Ruprecht RM. Postnatal passive immunization of neonatal macaques with a triple combination of human monoclonal antibodies against oral simian-human immunodeficiency virus challenge. J Virol. 2001 Aug; 75(16):7470-80.
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  93. Ruprecht R. Antibodies and HIV: new evidence. Interview with Ruth Ruprecht, M.D., Ph.D. Interview by David Scondras and John S. James. AIDS Treat News. 2001 May 25; (365):2-4.
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  94. Xu W, Smith-Franklin BA, Li PL, Wood C, He J, Du Q, Bhat GJ, Kankasa C, Katinger H, Cavacini LA, Posner MR, Burton DR, Chou TC, Ruprecht RM. Potent neutralization of primary human immunodeficiency virus clade C isolates with a synergistic combination of human monoclonal antibodies raised against clade B. J Hum Virol. 2001 Mar-Apr; 4(2):55-61.
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  95. Liska V, Hofmann-Lehmann R, Ruprecht RM. Infectivity of lentiviral DNA in animals. Dev Biol (Basel). 2001; 106:291-7; discussion 297-8, 317-29.
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  96. Hofmann-Lehmann R, Swenerton RK, Liska V, Leutenegger CM, Lutz H, McClure HM, Ruprecht RM. Sensitive and robust one-tube real-time reverse transcriptase-polymerase chain reaction to quantify SIV RNA load: comparison of one- versus two-enzyme systems. AIDS Res Hum Retroviruses. 2000 Sep 1; 16(13):1247-57.
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  97. Ruprecht RM, Hofmann-Lehmann R, Rasmussen RA, Vlasak J, Xu W. 1999: a time to re-evaluate AIDS vaccine strategies. J Hum Virol. 2000 Mar-Apr; 3(2):88-93.
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  98. Baba TW, Liska V, Hofmann-Lehmann R, Vlasak J, Xu W, Ayehunie S, Cavacini LA, Posner MR, Katinger H, Stiegler G, Bernacky BJ, Rizvi TA, Schmidt R, Hill LR, Keeling ME, Lu Y, Wright JE, Chou TC, Ruprecht RM. Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection. Nat Med. 2000 Feb; 6(2):200-6.
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  99. Ruprecht RM. Live attenuated AIDS viruses as vaccines: promise or peril? Immunol Rev. 1999 Aug; 170:135-49.
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  100. von Gegerfelt AS, Liska V, Ray NB, McClure HM, Ruprecht RM, Felber BK. Persistent infection of rhesus macaques by the rev-independent Nef(-) simian immunodeficiency virus SIVmac239: replication kinetics and genomic stability. J Virol. 1999 Jul; 73(7):6159-65.
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  101. Ruprecht RM, Baba TW, Liska V, Ray NB, Martin LN, Murphey-Corb M, Rizvi TA, Bernacky BJ, Keeling ME, McClure HM, Andersen J. Oral transmission of primate lentiviruses. J Infect Dis. 1999 May; 179 Suppl 3:S408-12.
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  102. Rasmussen RA, Sharma PL, Hu Y, Ruprecht RM. Vaccine protection by subinfectious doses of a live murine leukemia virus. Leukemia. 1999 Apr; 13 Suppl 1:S94-5.
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  103. Liska V, Khimani AH, Hofmann-Lehmann R, Fink AN, Vlasak J, Ruprecht RM. Viremia and AIDS in rhesus macaques after intramuscular inoculation of plasmid DNA encoding full-length SIVmac239. AIDS Res Hum Retroviruses. 1999 Mar 20; 15(5):445-50.
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  104. Baba TW, Liska V, Khimani AH, Ray NB, Dailey PJ, Penninck D, Bronson R, Greene MF, McClure HM, Martin LN, Ruprecht RM. Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques. Nat Med. 1999 Feb; 5(2):194-203.
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  105. Liska V, Ruprecht RM. Isolation of high-molecular-weight genomic DNA from intact biohazardous mammalian tissues. Biotechniques. 1999 Jan; 26(1):62-4, 66.
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  106. Ayehunie S, Belay A, Baba TW, Ruprecht RM. Inhibition of HIV-1 replication by an aqueous extract of Spirulina platensis (Arthrospira platensis). J Acquir Immune Defic Syndr Hum Retrovirol. 1998 May 1; 18(1):7-12.
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  107. Ruprecht RM, Baba TW, Liska V, Ayehunie S, Andersen J, Montefiori DC, Trichel A, Murphey-Corb M, Martin L, Rizvi TA, Bernacky BJ, Buchl SJ, Keeling M. Oral SIV, SHIV, and HIV type 1 infection. AIDS Res Hum Retroviruses. 1998 Apr; 14 Suppl 1:S97-103.
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  108. Li A, Katinger H, Posner MR, Cavacini L, Zolla-Pazner S, Gorny MK, Sodroski J, Chou TC, Baba TW, Ruprecht RM. Synergistic neutralization of simian-human immunodeficiency virus SHIV-vpu+ by triple and quadruple combinations of human monoclonal antibodies and high-titer anti-human immunodeficiency virus type 1 immunoglobulins. J Virol. 1998 Apr; 72(4):3235-40.
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  109. Khimani AH, Lim M, Graf TG, Smith TF, Ruprecht RM. Phylogenetic relationship of the complete Rauscher murine leukemia virus genome with other murine leukemia virus genomes. Virology. 1997 Nov 10; 238(1):64-7.
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  110. Liska V, Fultz PN, Su L, Ruprecht RM. Detection of simian T cell leukemia virus type I infection in seronegative macaques. AIDS Res Hum Retroviruses. 1997 Sep 1; 13(13):1147-53.
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  111. Ayehunie S, Garcia-Zepeda EA, Hoxie JA, Horuk R, Kupper TS, Luster AD, Ruprecht RM. Human immunodeficiency virus-1 entry into purified blood dendritic cells through CC and CXC chemokine coreceptors. Blood. 1997 Aug 15; 90(4):1379-86.
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  112. Li A, Baba TW, Sodroski J, Zolla-Pazner S, Gorny MK, Robinson J, Posner MR, Katinger H, Barbas CF, Burton DR, Chou TC, Ruprecht RM. Synergistic neutralization of a chimeric SIV/HIV type 1 virus with combinations of human anti-HIV type 1 envelope monoclonal antibodies or hyperimmune globulins. AIDS Res Hum Retroviruses. 1997 May 20; 13(8):647-56.
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  113. Liska V, Lerche NW, Ruprecht RM. Simultaneous detection of simian retrovirus type D serotypes 1, 2, and 3 by polymerase chain reaction. AIDS Res Hum Retroviruses. 1997 Mar 20; 13(5):433-7.
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  114. Trichel AM, Roberts ED, Wilson LA, Martin LN, Ruprecht RM, Murphey-Corb M. SIV/DeltaB670 transmission across oral, colonic, and vaginal mucosae in the macaque. J Med Primatol. 1997 Feb-Apr; 26(1-2):3-10.
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  115. Montefiori DC, Baba TW, Li A, Bilska M, Ruprecht RM. Neutralizing and infection-enhancing antibody responses do not correlate with the differential pathogenicity of SIVmac239delta3 in adult and infant rhesus monkeys. J Immunol. 1996 Dec 15; 157(12):5528-35.
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  116. Baba TW, Trichel AM, An L, Liska V, Martin LN, Murphey-Corb M, Ruprecht RM. Infection and AIDS in adult macaques after nontraumatic oral exposure to cell-free SIV. Science. 1996 Jun 7; 272(5267):1486-9.
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  117. Mildvan D, Bassiakos Y, Zucker ML, Hyslop N, Krown SE, Sacks HS, Zachary J, Paredes J, Fessel WJ, Rhame F, Kramer F, Fischl MA, Poiesz B, Wood K, Ruprecht RM, Kim J, Grossberg SE, Kasdan P, Bergé P, Marshak A, Pettinelli C. Synergy, activity and tolerability of zidovudine and interferon-alpha in patients with symptomatic HIV-1 infection: AIDS Clincal Trial Group 068. Antivir Ther. 1996 Apr; 1(2):77-88.
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  118. Ruprecht RM, Baba TW, Liska V. Attenuated HIV Vaccine: Caveats. Science. 1996 Mar 29; 271(5257):1790b-1b.
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  119. Ruprecht RM, Baba TW, Liska V. Attenuated HIV vaccine: caveats. Science. 1996 Mar 29; 271(5257):1790-2.
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  120. Ruprecht RM, Baba TW, Liska V, Bronson R, Penninck D, Greene MF. "Attenuated" simian immunodeficiency virus in macaque neonates. AIDS Res Hum Retroviruses. 1996 Mar 20; 12(5):459-60.
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  121. Ruprecht RM, Hu Y, Liska V, Rasmussen R, Sharma P. Correlates of immune protection after vaccination with attenuated live murine leukemia virus. AIDS Res Hum Retroviruses. 1996 Mar 20; 12(5):375-7.
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  122. Ruprecht RM, Baba TW, Rasmussen R, Hu Y, Sharma PL. Murine and simian retrovirus models: the threshold hypothesis. AIDS. 1996; 10 Suppl A:S33-40.
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  123. Ayehunie S, Groves RW, Bruzzese AM, Ruprecht RM, Kupper TS, Langhoff E. Acutely infected Langerhans cells are more efficient than T cells in disseminating HIV type 1 to activated T cells following a short cell-cell contact. AIDS Res Hum Retroviruses. 1995 Aug; 11(8):877-84.
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  124. Ruprecht RM, Baba TW, Greene MF. Attenuated vaccines for AIDS? Lancet. 1995 Jul 15; 346(8968):177-8.
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  125. Baba TW, Jeong YS, Pennick D, Bronson R, Greene MF, Ruprecht RM. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science. 1995 Mar 24; 267(5205):1820-5.
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  126. Finkel TH, Tudor-Williams G, Banda NK, Cotton MF, Curiel T, Monks C, Baba TW, Ruprecht RM, Kupfer A. Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes. Nat Med. 1995 Feb; 1(2):129-34.
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  127. Gama Sosa MA, Rosas DH, DeGasperi R, Morita E, Hutchison MR, Ruprecht RM. Negative regulation of the 5' long terminal repeat (LTR) by the 3' LTR in the murine proviral genome. J Virol. 1994 Apr; 68(4):2662-70.
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  128. Baba TW, Koch J, Mittler ES, Greene M, Wyand M, Penninck D, Ruprecht RM. Mucosal infection of neonatal rhesus monkeys with cell-free SIV. AIDS Res Hum Retroviruses. 1994 Apr; 10(4):351-7.
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  129. Ruprecht RM, Bronson R. Chemoprevention of retroviral infection: success is determined by virus inoculum strength and cellular immunity. DNA Cell Biol. 1994 Jan; 13(1):59-66.
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  130. Ruprecht RM, Fratazzi C, Sharma PL, Greene MF, Penninck D, Wyand M. Animal models for perinatal transmission of pathogenic viruses. Ann N Y Acad Sci. 1993 Oct 29; 693:213-28.
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  131. Fazely F, Sharma PL, Fratazzi C, Greene MF, Wyand MS, Memon MA, Penninck D, Ruprecht RM. Simian immunodeficiency virus infection via amniotic fluid: a model to study fetal immunopathogenesis and prophylaxis. J Acquir Immune Defic Syndr. 1993 Feb; 6(2):107-14.
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  132. Koch JA, Ruprecht RM. Animal models for anti-AIDS therapy. Antiviral Res. 1992 Aug; 19(2):81-109.
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  133. Ruprecht RM, Koch JA, Sharma PL, Armany RS. Development of antiviral treatment strategies in murine models. AIDS Res Hum Retroviruses. 1992 Jun; 8(6):997-1011.
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  134. Gama Sosa MA, DeGasperi R, Kim YS, Fazely F, Sharma P, Ruprecht RM. Serine phosphorylation-independent downregulation of cell-surface CD4 by nef. AIDS Res Hum Retroviruses. 1991 Nov; 7(11):859-60.
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  135. Kong XB, Zhu QY, Ruprecht RM, Watanabe KA, Zeidler JM, Gold JW, Polsky B, Armstrong D, Chou TC. Synergistic inhibition of human immunodeficiency virus type 1 replication in vitro by two-drug and three-drug combinations of 3'-azido-3'-deoxythymidine, phosphonoformate, and 2',3'-dideoxythymidine. Antimicrob Agents Chemother. 1991 Oct; 35(10):2003-11.
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  136. Fazely F, Dezube BJ, Allen-Ryan J, Pardee AB, Ruprecht RM. Pentoxifylline (Trental) decreases the replication of the human immunodeficiency virus type 1 in human peripheral blood mononuclear cells and in cultured T cells. Blood. 1991 Apr 15; 77(8):1653-6.
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  137. Sosa MA, Fazely F, Koch JA, Vercellotti SV, Ruprecht RM. N-carboxymethylchitosan-N,O-sulfate as an anti-HIV-1 agent. Biochem Biophys Res Commun. 1991 Jan 31; 174(2):489-96.
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  138. Fazely F, Haseltine WA, Rodger RF, Ruprecht RM. Postexposure chemoprophylaxis with ZDV or ZDV combined with interferon-alpha: failure after inoculating rhesus monkeys with a high dose of SIV. J Acquir Immune Defic Syndr. 1991; 4(11):1093-7.
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  139. Lee JS, Mullaney S, Bronson R, Sharpe AH, Jaenisch R, Balzarini J, De Clercq E, Ruprecht RM. Transplacental antiretroviral therapy with 9-(2-phosphonylmethoxyethyl)adenine is embryotoxic in transgenic mice. J Acquir Immune Defic Syndr. 1991; 4(9):833-8.
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  140. Hom RC, Finberg RW, Mullaney S, Ruprecht RM. Protective cellular retroviral immunity requires both CD4+ and CD8+ immune T cells. J Virol. 1991 Jan; 65(1):220-4.
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  141. Ruprecht RM, Bernard LD, Bronson R, Gama Sosa MA, Mullaney S. Castanospermine vs. its 6-O-butanoyl analog: a comparison of toxicity and antiviral activity in vitro and in vivo. J Acquir Immune Defic Syndr. 1991; 4(1):48-55.
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  142. Falcone A, Darnowski JW, Ruprecht RM, Chu SH, Brunetti I, Calabresi P. Different effect of benzylacyclouridine on the toxic and therapeutic effects of azidothymidine in mice. Blood. 1990 Dec 1; 76(11):2216-21.
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  143. Rosowsky A, Saha J, Fazely F, Koch J, Ruprecht RM. Inhibition of human immunodeficiency virus type 1 replication by phosphonoformate esters of 3'-azido-3'-deoxythymidine. Biochem Biophys Res Commun. 1990 Oct 15; 172(1):288-94.
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  144. Ruprecht RM, Bernard LD, Gama Sosa MA, Sosa MA, Fazely F, Koch J, Sharma PL, Mullaney S. Murine models for evaluating antiretroviral therapy. Cancer Res. 1990 Sep 1; 50(17 Suppl):5618S-5627S.
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  145. Ruprecht RM, Mullaney S, Bernard LD, Gama Sosa MA, Hom RC, Finberg RW. Vaccination with a live retrovirus: the nature of the protective immune response. Proc Natl Acad Sci U S A. 1990 Jul; 87(14):5558-62.
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  146. Ruprecht RM, Sharpe AH, Jaenisch R, Trites D. Analysis of 3'-azido-3'-deoxythymidine levels in tissues and milk by isocratic high-performance liquid chromatography. J Chromatogr. 1990 Jun 29; 528(2):371-83.
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  147. Mildvan D, Ruprecht R, Krown S, Pettinelli C. Methodological issues in AIDS clinical trials. Application of the combination index method in the design of a clinical antiretroviral trial: ACTG 068. J Acquir Immune Defic Syndr. 1990; 3 Suppl 2:S111-3 discussion S114-9.
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  148. Ruprecht RM, Chou TC, Chipty F, Sosa MG, Mullaney S, O'Brien L, Rosas D. Interferon-alpha and 3'-azido-3'-deoxythymidine are highly synergistic in mice and prevent viremia after acute retrovirus exposure. J Acquir Immune Defic Syndr. 1990; 3(6):591-600.
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  149. Sosa MA, DeGasperi R, Fazely F, Ruprecht RM. Human cell lines stably expressing HIV env and tat gene products. Biochem Biophys Res Commun. 1989 May 30; 161(1):305-11.
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  150. Gama Sosa MA, Hall JC, Schneider KE, Lukaszewicz GC, Ruprecht RM. Unusual DNA structures at the integration site of an HIV provirus. Biochem Biophys Res Commun. 1989 May 30; 161(1):134-42.
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  151. Rosowsky A, Solan VC, Sodroski JG, Ruprecht RM. Synthesis of the 2-chloro analogues of 3'-deoxyadenosine, 2',3'-dideoxyadenosine, and 2',3'-didehydro-2',3'-dideoxyadenosine as potential antiviral agents. J Med Chem. 1989 May; 32(5):1135-40.
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  152. Sharpe AH, Hunter JJ, Ruprecht RM, Jaenisch R. Maternal transmission of retroviral disease and strategies for preventing infection of the neonate. J Virol. 1989 Mar; 63(3):1049-53.
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  153. Ruprecht RM, Mullaney S, Andersen J, Bronson R. In vivo analysis of castanospermine, a candidate antiretroviral agent. J Acquir Immune Defic Syndr. 1989; 2(2):149-57.
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  154. Ruprecht RM. Murine models for antiretroviral therapy. Intervirology. 1989; 30 Suppl 1:2-11.
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  155. Sharpe AH, Hunter JJ, Ruprecht RM, Jaenisch R. Maternal transmission of retroviral disease: transgenic mice as a rapid test system for evaluating perinatal and transplacental antiretroviral therapy. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9792-6.
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  156. Gama Sosa MA, Hall JC, Ruprecht RM. Slipped DNA structures within the enhancer region of the Moloney murine leukemia virus. Biochem Biophys Res Commun. 1988 Oct 14; 156(1):417-23.
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  157. Ruprecht RM, Gama-Sosa MA, Rosas HD. Combination therapy after retroviral inoculation. Lancet. 1988 Jan 30; 1(8579):239-40.
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  158. Sharpe AH, Jaenisch R, Ruprecht RM. Retroviruses and mouse embryos: a rapid model for neurovirulence and transplacental antiviral therapy. Science. 1987 Jun 26; 236(4809):1671-4.
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  159. Ruprecht RM, O'Brien LG, Rossoni LD, Nusinoff-Lehrman S. Suppression of mouse viraemia and retroviral disease by 3'-azido-3'-deoxythymidine. Nature. 1986 Oct 2-8; 323(6087):467-9.
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  160. Ruprecht RM, Lorsch J, Trites DH. Analysis of suramin plasma levels by ion-pair high-performance liquid chromatography under isocratic conditions. J Chromatogr. 1986 Jun 13; 378(2):498-502.
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  161. Roth EF, Ruprecht RM, Schulman S, Vanderberg J, Olson JA. Ribose metabolism and nucleic acid synthesis in normal and glucose-6-phosphate dehydrogenase-deficient human erythrocytes infected with Plasmodium falciparum. J Clin Invest. 1986 Apr; 77(4):1129-35.
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  162. Ruprecht RM, Rossoni LD, Haseltine WA, Broder S. Suppression of retroviral propagation and disease by suramin in murine systems. Proc Natl Acad Sci U S A. 1985 Nov; 82(22):7733-7.
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  163. Rosen CA, Haseltine WA, Lenz J, Ruprecht R, Cloyd MW. Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences. J Virol. 1985 Sep; 55(3):862-6.
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  164. Frei E, Cucchi CA, Rosowsky A, Tantravahi R, Bernal S, Ervin TJ, Ruprecht RM, Haseltine WA. Alkylating agent resistance: in vitro studies with human cell lines. Proc Natl Acad Sci U S A. 1985 Apr; 82(7):2158-62.
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  165. Daniel ES, Ludwig SL, Lewin KJ, Ruprecht RM, Rajacich GM, Schwabe AD. The Cronkhite-Canada Syndrome. An analysis of clinical and pathologic features and therapy in 55 patients. Medicine (Baltimore). 1982 Sep; 61(5):293-309.
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  166. Cline MJ, Stang H, Mercola K, Morse L, Ruprecht R, Brown J, Salser W. Gene transfer in intact animals. Nature. 1980 Apr 3; 284(5755):422-5.
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  167. Collins GM, Taft P, Green RD, Ruprecht R, Halasz NA. Adenine nucleotide levels in preserved and ischemically injured canine kidneys. World J Surg. 1977 Mar; 2(1):237-43.
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  168. Gloor M, Ludwig G, Hildebrandt L, Ruprecht R. [The significance of the columar structure of the stratum corneum for the effect of light on the skin]. Berufsdermatosen. 1976; 24(1):1-6.
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  169. Sweet RW, Goodman NC, Cho JR, Ruprecht RM, Redfield RR, Spiegelman S. The presence of unique DNA sequences after viral induction of leukemia in mice. (RNA tumor virus-nucleic acid hybridization-insertion of viral DNA). Proc Natl Acad Sci U S A. 1974 May; 71(5):1705-9.
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  170. Goodman NC, Ruprecht RM, Sweet RW, Massey R, Deinhardt F, Spiegelman S. Viral-related DNA sequences before and after transformation by RNA tumor viruses. Int J Cancer. 1973 Nov 15; 12(3):752-60.
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  171. Ruprecht RM, Goodman NC, Spiegelman S. Determination of natural host taxonomy of RNA tumor viruses by molecular hybridization: application to RD-114, a candidate human virus. Proc Natl Acad Sci U S A. 1973 May; 70(5):1437-41.
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  172. Ruprecht RM, Goodman NC, Spiegelman S. Conditions for the selective synthesis of DNA complementary to template RNA. Biochim Biophys Acta. 1973 Jan 19; 294(1):192-203.
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  173. Ruprecht RM, Goodman NC, Spiegelman S. Conditions for the selective synthesis of DNA complementary to template RNA. Biochim Biophys Acta. 1973 Jan 19; 294(2):192-203.
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  174. Bishop DH, Ruprecht R, Simpson RW, Spiegelman S. Deoxyribonucleic acid polymerase of Rous sarcoma virus: reaction conditions and analysis of the reaction product nucleic acids. J Virol. 1971 Nov; 8(5):730-41.
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