Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Arun J. Sharma, PH.D.

TitleAssistant Professor of Medicine
InstitutionJoslin Diabetes Center
DepartmentMedicine
AddressJoslin Diabetes Center
Islet Transp & Cell Bio - 5
One Joslin Place
Boston MA 02215
Phone617/264-2756
Fax617/309-2589

 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Media Core (JDC) - Core services (1)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Hu He K, Juhl K, Karadimos M, El Khattabi I, Fitzpatrick C, Bonner-Weir S, Sharma A. Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA. Dev Biol. 2014 Jan 1; 385(1):2-12.
    View in: PubMed
  2. Guo L, Inada A, Aguayo-Mazzucato C, Hollister-Lock J, Fujitani Y, Weir GC, Wright CV, Sharma A, Bonner-Weir S. PDX1 in Ducts Is Not Required for Postnatal Formation of ß-Cells but Is Necessary for Their Subsequent Maturation. Diabetes. 2013 Oct; 62(10):3459-68.
    View in: PubMed
  3. El Khattabi I, Sharma A. Preventing p38 MAPK-Mediated MafA Degradation Ameliorates ß-Cell Dysfunction under Oxidative Stress. Mol Endocrinol. 2013 Jul; 27(7):1078-90.
    View in: PubMed
  4. Aguayo-Mazzucato C, Zavacki AM, Marinelarena A, Hollister-Lock J, El Khattabi I, Marsili A, Weir GC, Sharma A, Larsen PR, Bonner-Weir S. Thyroid Hormone Promotes Postnatal Rat Pancreatic ß-Cell Development and Glucose-Responsive Insulin Secretion Through MAFA. Diabetes. 2013 May; 62(5):1569-80.
    View in: PubMed
  5. Bonner-Weir S, Guo L, Li WC, Ouziel-Yahalom L, Weir GC, Sharma A. Islet neogenesis: a possible pathway for Beta-cell replenishment. Rev Diabet Stud. 2012; 9(4):407-16.
    View in: PubMed
  6. Katsuta H, Aguayo-Mazzucato C, Katsuta R, Akashi T, Hollister-Lock J, Sharma AJ, Bonner-Weir S, Weir GC. Subpopulations of GFP-Marked Mouse Pancreatic ß-Cells Differ in Size, Granularity, and Insulin Secretion. Endocrinology. 2012 Nov; 153(11):5180-7.
    View in: PubMed
  7. Cheng Y, Sk UH, Zhang Y, Ren X, Zhang L, Huber-Keener KJ, Sun YW, Liao J, Amin S, Sharma AK, Yang JM. Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death. PLoS One. 2012; 7(4):e35104.
    View in: PubMed
  8. Paliwal P, Sharma A, Tandon R, Sharma N, Titiyal JS, Sen S, Vajpayee RB. Molecular genetic analysis of macular corneal dystrophy patients from North India. Ophthalmic Res. 2012; 48(1):28-32.
    View in: PubMed
  9. Sharma AK, Kline CL, Berg A, Amin S, Irby RB. The Akt inhibitor ISC-4 activates prostate apoptosis response protein-4 and reduces colon tumor growth in a nude mouse model. Clin Cancer Res. 2011 Jul 1; 17(13):4474-83.
    View in: PubMed
  10. Paliwal P, Tandon R, Dube D, Kaur P, Sharma A. Familial segregation of a VSX1 mutation adds a new dimension to its role in the causation of keratoconus. Mol Vis. 2011; 17:481-5.
    View in: PubMed
  11. Paliwal P, Sharma A, Tandon R, Sharma N, Titiyal JS, Sen S, Nag TC, Vajpayee RB. Congenital hereditary endothelial dystrophy - mutation analysis of SLC4A11 and genotype-phenotype correlation in a North Indian patient cohort. Mol Vis. 2010; 16:2955-63.
    View in: PubMed
  12. Bonner-Weir S, Li WC, Ouziel-Yahalom L, Guo L, Weir GC, Sharma A. Beta-cell growth and regeneration: replication is only part of the story. Diabetes. 2010 Oct; 59(10):2340-8.
    View in: PubMed
  13. Paliwal P, Sharma A, Tandon R, Sharma N, Titiyal JS, Sen S, Kaur P, Dube D, Vajpayee RB. TGFBI mutation screening and genotype-phenotype correlation in north Indian patients with corneal dystrophies. Mol Vis. 2010; 16:1429-38.
    View in: PubMed
  14. Li WC, Rukstalis JM, Nishimura W, Tchipashvili V, Habener JF, Sharma A, Bonner-Weir S. Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci. 2010 Aug 15; 123(Pt 16):2792-802.
    View in: PubMed
  15. Marselli L, Thorne J, Dahiya S, Sgroi DC, Sharma A, Bonner-Weir S, Marchetti P, Weir GC. Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One. 2010; 5(7):e11499.
    View in: PubMed
  16. Murray IA, Krishnegowda G, DiNatale BC, Flaveny C, Chiaro C, Lin JM, Sharma AK, Amin S, Perdew GH. Development of a selective modulator of aryl hydrocarbon (Ah) receptor activity that exhibits anti-inflammatory properties. Chem Res Toxicol. 2010 May 17; 23(5):955-66.
    View in: PubMed
  17. Wang BD, Kline CL, Pastor DM, Olson TL, Frank B, Luu T, Sharma AK, Robertson G, Weirauch MT, Patierno SR, Stuart JM, Irby RB, Lee NH. Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network. Mol Cancer. 2010; 9:98.
    View in: PubMed
  18. Paliwal P, Gupta J, Tandon R, Sharma N, Titiyal JS, Kashyap S, Sen S, Kaur P, Dube D, Sharma A, Vajpayee RB. Identification and characterization of a novel TACSTD2 mutation in gelatinous drop-like corneal dystrophy. Mol Vis. 2010; 16:729-39.
    View in: PubMed
  19. Juhl K, Bonner-Weir S, Sharma A. Regenerating pancreatic beta-cells: plasticity of adult pancreatic cells and the feasibility of in-vivo neogenesis. Curr Opin Organ Transplant. 2010 Feb; 15(1):79-85.
    View in: PubMed
  20. Aye T, Toschi E, Sharma A, Sgroi D, Bonner-Weir S. Identification of markers for newly formed beta-cells in the perinatal period: a time of recognized beta-cell immaturity. J Histochem Cytochem. 2010 Apr; 58(4):369-76.
    View in: PubMed
  21. Paliwal P, Gupta J, Tandon R, Sharma A, Vajpayee RB. Clinical and genetic profile of Avellino corneal dystrophy in 2 families from north India. Arch Ophthalmol. 2009 Oct; 127(10):1373-6.
    View in: PubMed
  22. Sharma AK, Fuller NJ, Sullivan RR, Fulton N, Hota PV, Harrington DA, Villano J, Hagerty JA, Cheng EY. Defined populations of bone marrow derived mesenchymal stem and endothelial progenitor cells for bladder regeneration. J Urol. 2009 Oct; 182(4 Suppl):1898-905.
    View in: PubMed
  23. Borowiec M, Liew CW, Thompson R, Boonyasrisawat W, Hu J, Mlynarski WM, El Khattabi I, Kim SH, Marselli L, Rich SS, Krolewski AS, Bonner-Weir S, Sharma A, Sale M, Mychaleckyj JC, Kulkarni RN, Doria A. Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction. Proc Natl Acad Sci U S A. 2009 Aug 25; 106(34):14460-5.
    View in: PubMed
  24. Nishimura W, Bonner-Weir S, Sharma A. Expression of MafA in pancreatic progenitors is detrimental for pancreatic development. Dev Biol. 2009 Sep 1; 333(1):108-20.
    View in: PubMed
  25. Kondo T, El Khattabi I, Nishimura W, Laybutt DR, Geraldes P, Shah S, King G, Bonner-Weir S, Weir G, Sharma A. p38 MAPK is a major regulator of MafA protein stability under oxidative stress. Mol Endocrinol. 2009 Aug; 23(8):1281-90.
    View in: PubMed
  26. Sharma A, Sharma AK, Madhunapantula SV, Desai D, Huh SJ, Mosca P, Amin S, Robertson GP. Targeting Akt3 signaling in malignant melanoma using isoselenocyanates. Clin Cancer Res. 2009 Mar 1; 15(5):1674-85.
    View in: PubMed
  27. Inada A, Nienaber C, Katsuta H, Fujitani Y, Levine J, Morita R, Sharma A, Bonner-Weir S. Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19915-9.
    View in: PubMed
  28. Dodge R, Loomans C, Sharma A, Bonner-Weir S. Developmental pathways during in vitro progression of human islet neogenesis. Differentiation. 2009 Feb; 77(2):135-47.
    View in: PubMed
  29. Bonner-Weir S, Inada A, Yatoh S, Li WC, Aye T, Toschi E, Sharma A. Transdifferentiation of pancreatic ductal cells to endocrine beta-cells. Biochem Soc Trans. 2008 Jun; 36(Pt 3):353-6.
    View in: PubMed
  30. Nishimura W, Rowan S, Salameh T, Maas RL, Bonner-Weir S, Sell SM, Sharma A. Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice. Dev Biol. 2008 Feb 15; 314(2):443-56.
    View in: PubMed
  31. Marselli L, Thorne J, Ahn YB, Omer A, Sgroi DC, Libermann T, Otu HH, Sharma A, Bonner-Weir S, Weir GC. Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab. 2008 Mar; 93(3):1046-53.
    View in: PubMed
  32. Yatoh S, Dodge R, Akashi T, Omer A, Sharma A, Weir GC, Bonner-Weir S. Differentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes. 2007 Jul; 56(7):1802-9.
    View in: PubMed
  33. Yatoh S, Akashi T, Chan PP, Kaneto H, Sharma A, Bonner-Weir S, Weir GC. NeuroD and reaggregation induce beta-cell specific gene expression in cultured hepatocytes. Diabetes Metab Res Rev. 2007 Mar; 23(3):239-49.
    View in: PubMed
  34. López-Avalos MD, Duvivier-Kali VF, Xu G, Bonner-Weir S, Sharma A, Weir GC. Evidence for a role of the ubiquitin-proteasome pathway in pancreatic islets. Diabetes. 2006 May; 55(5):1223-31.
    View in: PubMed
  35. Bonner-Weir S, Sharma A. Are there pancreatic progenitor cells from which new islets form after birth? Nat Clin Pract Endocrinol Metab. 2006 May; 2(5):240-1.
    View in: PubMed
  36. Nishimura W, Kondo T, Salameh T, El Khattabi I, Dodge R, Bonner-Weir S, Sharma A. A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol. 2006 May 15; 293(2):526-39.
    View in: PubMed
  37. Nishimura W, Salameh T, Kondo T, Sharma A. Regulation of insulin gene expression by overlapping DNA-binding elements. Biochem J. 2005 Nov 15; 392(Pt 1):181-9.
    View in: PubMed
  38. Bonner-Weir S, Toschi E, Inada A, Reitz P, Fonseca SY, Aye T, Sharma A. The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr Diabetes. 2004; 5 Suppl 2:16-22.
    View in: PubMed
  39. Patané G, Kaneto H, Toschi E, Sharma A, Gupta S, Weir GC. Induction of Mad expression leads to augmentation of insulin gene transcription. Biochem Biophys Res Commun. 2003 Apr 18; 303(4):1199-208.
    View in: PubMed
  40. Bonner-Weir S, Sharma A. Pancreatic stem cells. J Pathol. 2002 Jul; 197(4):519-26.
    View in: PubMed
  41. Laybutt DR, Weir GC, Kaneto H, Lebet J, Palmiter RD, Sharma A, Bonner-Weir S. Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. Diabetes. 2002 Jun; 51(6):1793-804.
    View in: PubMed
  42. Olbrot M, Rud J, Moss LG, Sharma A. Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci U S A. 2002 May 14; 99(10):6737-42.
    View in: PubMed
  43. Laybutt DR, Kaneto H, Hasenkamp W, Grey S, Jonas JC, Sgroi DC, Groff A, Ferran C, Bonner-Weir S, Sharma A, Weir GC. Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes. 2002 Feb; 51(2):413-23.
    View in: PubMed
  44. Kaneto H, Sharma A, Suzuma K, Laybutt DR, Xu G, Bonner-Weir S, Weir GC. Induction of c-Myc expression suppresses insulin gene transcription by inhibiting NeuroD/BETA2-mediated transcriptional activation. J Biol Chem. 2002 Apr 12; 277(15):12998-3006.
    View in: PubMed
  45. Laybutt DR, Sharma A, Sgroi DC, Gaudet J, Bonner-Weir S, Weir GC. Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J Biol Chem. 2002 Mar 29; 277(13):10912-21.
    View in: PubMed
  46. Kaneto H, Suzuma K, Sharma A, Bonner-Weir S, King GL, Weir GC. Involvement of protein kinase C beta 2 in c-myc induction by high glucose in pancreatic beta-cells. J Biol Chem. 2002 Feb 1; 277(5):3680-5.
    View in: PubMed
  47. Sharma A, Taneja M, Rietz P, Weitekamp J, Bonner-Weir S. Novel pancreatic precursor cell lines for studying beta-cell differentiation. Diabetes. 2001 Feb; 50 Suppl 1:S42-3.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Sharma's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_