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Natasha B. Lasko, PH.D.

TitleAssistant Professor of Psychology in the Department of Psychiatry
InstitutionMassachusetts General Hospital
DepartmentPsychiatry
AddressMassachusetts General Hospital
Cny-120
149 13th Street
Charlestown MA 02129
Phone617/726-5330
Fax603/668-6574

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bauer MR, Ruef AM, Pineles SL, Japuntich SJ, Macklin ML, Lasko NB, Orr SP. Psychophysiological assessment of PTSD: A potential research domain criteria construct. Psychol Assess. 2013 Sep; 25(3):1037-43.
    View in: PubMed
  2. Elman I, Gurvits TV, Tschibelu E, Spring JD, Lasko NB, Pitman RK. Neurological soft signs in individuals with pathological gambling. PLoS One. 2013; 8(4):e60885.
    View in: PubMed
  3. Orr SP, Lasko NB, Macklin ML, Pineles SL, Chang Y, Pitman RK. Predicting post-trauma stress symptoms from pre-trauma psychophysiologic reactivity, personality traits and measures of psychopathology. Biol Mood Anxiety Disord. 2012; 2(1):8.
    View in: PubMed
  4. Pineles SL, Rasmusson AM, Yehuda R, Lasko NB, Macklin ML, Pitman RK, Orr SP. Predicting emotional responses to potentially traumatic events from pre-exposure waking cortisol levels: a longitudinal study of police and firefighters. Anxiety Stress Coping. 2013 May; 26(3):241-53.
    View in: PubMed
  5. Shin LM, Bush G, Milad MR, Lasko NB, Brohawn KH, Hughes KC, Macklin ML, Gold AL, Karpf RD, Orr SP, Rauch SL, Pitman RK. Exaggerated activation of dorsal anterior cingulate cortex during cognitive interference: a monozygotic twin study of posttraumatic stress disorder. Am J Psychiatry. 2011 Sep; 168(9):979-85.
    View in: PubMed
  6. Gold AL, Shin LM, Orr SP, Carson MA, Rauch SL, Macklin ML, Lasko NB, Metzger LJ, Dougherty DD, Alpert NM, Fischman AJ, Pitman RK. Decreased regional cerebral blood flow in medial prefrontal cortex during trauma-unrelated stressful imagery in Vietnam veterans with post-traumatic stress disorder. Psychol Med. 2011 Dec; 41(12):2563-72.
    View in: PubMed
  7. Hoge EA, Worthington JJ, Nagurney JT, Chang Y, Kay EB, Feterowski CM, Katzman AR, Goetz JM, Rosasco ML, Lasko NB, Zusman RM, Pollack MH, Orr SP, Pitman RK. Effect of acute posttrauma propranolol on PTSD outcome and physiological responses during script-driven imagery. CNS Neurosci Ther. 2012 Jan; 18(1):21-7.
    View in: PubMed
  8. Gilbertson MW, McFarlane AC, Weathers FW, Keane TM, Yehuda R, Shalev AY, Lasko NB, Goetz JM, Pitman RK. Is trauma a causal agent of psychopathologic symptoms in posttraumatic stress disorder? Findings from identical twins discordant for combat exposure. J Clin Psychiatry. 2010 Oct; 71(10):1324-30.
    View in: PubMed
  9. Shin LM, Lasko NB, Macklin ML, Karpf RD, Milad MR, Orr SP, Goetz JM, Fischman AJ, Rauch SL, Pitman RK. Resting metabolic activity in the cingulate cortex and vulnerability to posttraumatic stress disorder. Arch Gen Psychiatry. 2009 Oct; 66(10):1099-107.
    View in: PubMed
  10. Milad MR, Pitman RK, Ellis CB, Gold AL, Shin LM, Lasko NB, Zeidan MA, Handwerger K, Orr SP, Rauch SL. Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder. Biol Psychiatry. 2009 Dec 15; 66(12):1075-82.
    View in: PubMed
  11. Metzger LJ, Carson MA, Lasko NB, Paulus LA, Orr SP, Pitman RK, Yehuda R. Basal and suppressed salivary cortisol in female Vietnam nurse veterans with and without PTSD. Psychiatry Res. 2008 Dec 15; 161(3):330-5.
    View in: PubMed
  12. Metzger LJ, Clark CR, McFarlane AC, Veltmeyer MD, Lasko NB, Paige SR, Pitman RK, Orr SP. Event-related potentials to auditory stimuli in monozygotic twins discordant for combat: association with PTSD. Psychophysiology. 2009 Jan; 46(1):172-8.
    View in: PubMed
  13. Milad MR, Orr SP, Lasko NB, Chang Y, Rauch SL, Pitman RK. Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin study. J Psychiatr Res. 2008 Jun; 42(7):515-20.
    View in: PubMed
  14. Hopper JW, Pitman RK, Su Z, Heyman GM, Lasko NB, Macklin ML, Orr SP, Lukas SE, Elman I. Probing reward function in posttraumatic stress disorder: expectancy and satisfaction with monetary gains and losses. J Psychiatr Res. 2008 Aug; 42(10):802-7.
    View in: PubMed
  15. Elman I, Chi WH, Gurvits TV, Ryan ET, Lasko NB, Lukas SE, Pitman RK. Impaired reproduction of three-dimensional objects by cocaine-dependent subjects. J Neuropsychiatry Clin Neurosci. 2008; 20(4):478-84.
    View in: PubMed
  16. Shin LM, Bush G, Whalen PJ, Handwerger K, Cannistraro PA, Wright CI, Martis B, Macklin ML, Lasko NB, Orr SP, Pitman RK, Rauch SL. Dorsal anterior cingulate function in posttraumatic stress disorder. J Trauma Stress. 2007 Oct; 20(5):701-12.
    View in: PubMed
  17. Carson MA, Metzger LJ, Lasko NB, Paulus LA, Morse AE, Pitman RK, Orr SP. Physiologic reactivity to startling tones in female Vietnam nurse veterans with PTSD. J Trauma Stress. 2007 Oct; 20(5):657-66.
    View in: PubMed
  18. Gilbertson MW, Williston SK, Paulus LA, Lasko NB, Gurvits TV, Shenton ME, Pitman RK, Orr SP. Configural cue performance in identical twins discordant for posttraumatic stress disorder: theoretical implications for the role of hippocampal function. Biol Psychiatry. 2007 Sep 1; 62(5):513-20.
    View in: PubMed
  19. Gilbertson MW, Paulus LA, Williston SK, Gurvits TV, Lasko NB, Pitman RK, Orr SP. Neurocognitive function in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorder. J Abnorm Psychol. 2006 Aug; 115(3):484-95.
    View in: PubMed
  20. Orr SP, Milad MR, Metzger LJ, Lasko NB, Gilbertson MW, Pitman RK. Effects of beta blockade, PTSD diagnosis, and explicit threat on the extinction and retention of an aversively conditioned response. Biol Psychol. 2006 Oct; 73(3):262-71.
    View in: PubMed
  21. Pitman RK, Gilbertson MW, Gurvits TV, May FS, Lasko NB, Metzger LJ, Shenton ME, Yehuda R, Orr SP. Clarifying the origin of biological abnormalities in PTSD through the study of identical twins discordant for combat exposure. Ann N Y Acad Sci. 2006 Jul; 1071:242-54.
    View in: PubMed
  22. Gurvits TV, Metzger LJ, Lasko NB, Cannistraro PA, Tarhan AS, Gilbertson MW, Orr SP, Charbonneau AM, Wedig MM, Pitman RK. Subtle neurologic compromise as a vulnerability factor for combat-related posttraumatic stress disorder: results of a twin study. Arch Gen Psychiatry. 2006 May; 63(5):571-6.
    View in: PubMed
  23. Elman I, Ariely D, Mazar N, Aharon I, Lasko NB, Macklin ML, Orr SP, Lukas SE, Pitman RK. Probing reward function in post-traumatic stress disorder with beautiful facial images. Psychiatry Res. 2005 Jun 30; 135(3):179-83.
    View in: PubMed
  24. Shin LM, Wright CI, Cannistraro PA, Wedig MM, McMullin K, Martis B, Macklin ML, Lasko NB, Cavanagh SR, Krangel TS, Orr SP, Pitman RK, Whalen PJ, Rauch SL. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry. 2005 Mar; 62(3):273-81.
    View in: PubMed
  25. McNally RJ, Lasko NB, Clancy SA, Macklin ML, Pitman RK, Orr SP. Psychophysiological responding during script-driven imagery in people reporting abduction by space aliens. Psychol Sci. 2004 Jul; 15(7):493-7.
    View in: PubMed
  26. Metzger LJ, Paige SR, Carson MA, Lasko NB, Paulus LA, Pitman RK, Orr SP. PTSD arousal and depression symptoms associated with increased right-sided parietal EEG asymmetry. J Abnorm Psychol. 2004 May; 113(2):324-9.
    View in: PubMed
  27. Shin LM, Orr SP, Carson MA, Rauch SL, Macklin ML, Lasko NB, Peters PM, Metzger LJ, Dougherty DD, Cannistraro PA, Alpert NM, Fischman AJ, Pitman RK. Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD. Arch Gen Psychiatry. 2004 Feb; 61(2):168-76.
    View in: PubMed
  28. Shin LM, Shin PS, Heckers S, Krangel TS, Macklin ML, Orr SP, Lasko N, Segal E, Makris N, Richert K, Levering J, Schacter DL, Alpert NM, Fischman AJ, Pitman RK, Rauch SL. Hippocampal function in posttraumatic stress disorder. Hippocampus. 2004; 14(3):292-300.
    View in: PubMed
  29. Orr SP, Metzger LJ, Lasko NB, Macklin ML, Hu FB, Shalev AY, Pitman RK. Physiologic responses to sudden, loud tones in monozygotic twins discordant for combat exposure: association with posttraumatic stress disorder. Arch Gen Psychiatry. 2003 Mar; 60(3):283-8.
    View in: PubMed
  30. Gurvits TV, Lasko NB, Repak AL, Metzger LJ, Orr SP, Pitman RK. Performance on visuospatial copying tasks in individuals with chronic posttraumatic stress disorder. Psychiatry Res. 2002 Nov 15; 112(3):263-8.
    View in: PubMed
  31. Gilbertson MW, Shenton ME, Ciszewski A, Kasai K, Lasko NB, Orr SP, Pitman RK. Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma. Nat Neurosci. 2002 Nov; 5(11):1242-7.
    View in: PubMed
  32. Gurvits TV, Carson MA, Metzger L, Croteau HB, Lasko NB, Orr SP, Pitman RK. Absence of selected neurological soft signs in Vietnam nurse veterans with post-traumatic stress disorder. Psychiatry Res. 2002 May 15; 110(1):81-5.
    View in: PubMed
  33. Pitman RK, Sanders KM, Zusman RM, Healy AR, Cheema F, Lasko NB, Cahill L, Orr SP. Pilot study of secondary prevention of posttraumatic stress disorder with propranolol. Biol Psychiatry. 2002 Jan 15; 51(2):189-92.
    View in: PubMed
  34. Metzger LJ, Carson MA, Paulus LA, Lasko NB, Paige SR, Pitman RK, Orr SP. Event-related potentials to auditory stimuli in female Vietnam nurse veterans with posttraumatic stress disorder. Psychophysiology. 2002 Jan; 39(1):49-63.
    View in: PubMed
  35. Shin LM, Whalen PJ, Pitman RK, Bush G, Macklin ML, Lasko NB, Orr SP, McInerney SC, Rauch SL. An fMRI study of anterior cingulate function in posttraumatic stress disorder. Biol Psychiatry. 2001 Dec 15; 50(12):932-42.
    View in: PubMed
  36. Gilbertson MW, Gurvits TV, Lasko NB, Orr SP, Pitman RK. Multivariate assessment of explicit memory function in combat veterans with posttraumatic stress disorder. J Trauma Stress. 2001 Apr; 14(2):413-32.
    View in: PubMed
  37. Carson MA, Paulus LA, Lasko NB, Metzger LJ, Wolfe J, Orr SP, Pitman RK. Psychophysiologic assessment of posttraumatic stress disorder in Vietnam nurse veterans who witnessed injury or death. J Consult Clin Psychol. 2000 Oct; 68(5):890-7.
    View in: PubMed
  38. Rauch SL, Whalen PJ, Shin LM, McInerney SC, Macklin ML, Lasko NB, Orr SP, Pitman RK. Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder: a functional MRI study. Biol Psychiatry. 2000 May 1; 47(9):769-76.
    View in: PubMed
  39. Orr SP, Metzger LJ, Lasko NB, Macklin ML, Peri T, Pitman RK. De novo conditioning in trauma-exposed individuals with and without posttraumatic stress disorder. J Abnorm Psychol. 2000 May; 109(2):290-8.
    View in: PubMed
  40. Gurvits TV, Gilbertson MW, Lasko NB, Tarhan AS, Simeon D, Macklin ML, Orr SP, Pitman RK. Neurologic soft signs in chronic posttraumatic stress disorder. Arch Gen Psychiatry. 2000 Feb; 57(2):181-6.
    View in: PubMed
  41. Macklin ML, Metzger LJ, Lasko NB, Berry NJ, Orr SP, Pitman RK. Five-year follow-up study of eye movement desensitization and reprocessing therapy for combat-related posttraumatic stress disorder. Compr Psychiatry. 2000 Jan-Feb; 41(1):24-7.
    View in: PubMed
  42. Metzger LJ, Orr SP, Berry NJ, Ahern CE, Lasko NB, Pitman RK. Physiologic reactivity to startling tones in women with posttraumatic stress disorder. J Abnorm Psychol. 1999 May; 108(2):347-52.
    View in: PubMed
  43. Shin LM, McNally RJ, Kosslyn SM, Thompson WL, Rauch SL, Alpert NM, Metzger LJ, Lasko NB, Orr SP, Pitman RK. Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation. Am J Psychiatry. 1999 Apr; 156(4):575-84.
    View in: PubMed
  44. Orr SP, Lasko NB, Metzger LJ, Berry NJ, Ahern CE, Pitman RK. Psychophysiologic assessment of women with posttraumatic stress disorder resulting from childhood sexual abuse. J Consult Clin Psychol. 1998 Dec; 66(6):906-13.
    View in: PubMed
  45. McNally RJ, Metzger LJ, Lasko NB, Clancy SA, Pitman RK. Directed forgetting of trauma cues in adult survivors of childhood sexual abuse with and without posttraumatic stress disorder. J Abnorm Psychol. 1998 Nov; 107(4):596-601.
    View in: PubMed
  46. Macklin ML, Metzger LJ, Litz BT, McNally RJ, Lasko NB, Orr SP, Pitman RK. Lower precombat intelligence is a risk factor for posttraumatic stress disorder. J Consult Clin Psychol. 1998 Apr; 66(2):323-6.
    View in: PubMed
  47. Metzger LJ, Orr SP, Lasko NB, Pitman RK. Auditory event-related potentials to tone stimuli in combat-related posttraumatic stress disorder. Biol Psychiatry. 1997 Dec 1; 42(11):1006-15.
    View in: PubMed
  48. Orr SP, Lasko NB, Metzger LJ, Pitman RK. Physiologic responses to non-startling tones in Vietnam veterans with post-traumatic stress disorder. Psychiatry Res. 1997 Nov 14; 73(1-2):103-7.
    View in: PubMed
  49. Gilbertson MW, Gurvits TV, Lasko NB, Pitman RK. Neuropsychological assessment of Vietnam combat veterans with and without PTSD. Ann N Y Acad Sci. 1997 Jun 21; 821:476-9.
    View in: PubMed
  50. Orr SP, Lasko NB, Metzger LJ, Berry NJ, Ahern CE, Pitman RK. Psychophysiologic assessment of PTSD in adult females sexually abused during childhood. Ann N Y Acad Sci. 1997 Jun 21; 821:491-3.
    View in: PubMed
  51. Gurvits TV, Gilbertson MW, Lasko NB, Orr SP, Pitman RK. Neurological status of combat veterans and adult survivors of sexual abuse PTSD. Ann N Y Acad Sci. 1997 Jun 21; 821:468-71.
    View in: PubMed
  52. Shin LM, McNally RJ, Kosslyn SM, Thompson WL, Rauch SL, Alpert NM, Metzger LJ, Lasko NB, Orr SP, Pitman RK. A positron emission tomographic study of symptom provocation in PTSD. Ann N Y Acad Sci. 1997 Jun 21; 821:521-3.
    View in: PubMed
  53. Metzger LJ, Orr SP, Lasko NB, Berry NJ, Pitman RK. Evidence for diminished P3 amplitudes in PTSD. Ann N Y Acad Sci. 1997 Jun 21; 821:499-503.
    View in: PubMed
  54. Metzger LJ, Orr SP, Lasko NB, McNally RJ, Pitman RK. Seeking the source of emotional Stroop interference effects in PTSD: a study of P3s to traumatic words. Integr Physiol Behav Sci. 1997 Jan-Mar; 32(1):43-51.
    View in: PubMed
  55. Gurvits TV, Shenton ME, Hokama H, Ohta H, Lasko NB, Gilbertson MW, Orr SP, Kikinis R, Jolesz FA, McCarley RW, Pitman RK. Magnetic resonance imaging study of hippocampal volume in chronic, combat-related posttraumatic stress disorder. Biol Psychiatry. 1996 Dec 1; 40(11):1091-9.
    View in: PubMed
  56. McNally RJ, Lasko NB, Macklin ML, Pitman RK. Autobiographical memory disturbance in combat-related posttraumatic stress disorder. Behav Res Ther. 1995 Jul; 33(6):619-30.
    View in: PubMed
  57. Orr SP, Lasko NB, Shalev AY, Pitman RK. Physiologic responses to loud tones in Vietnam veterans with posttraumatic stress disorder. J Abnorm Psychol. 1995 Feb; 104(1):75-82.
    View in: PubMed
  58. Lasko NB, Gurvits TV, Kuhne AA, Orr SP, Pitman RK. Aggression and its correlates in Vietnam veterans with and without chronic posttraumatic stress disorder. Compr Psychiatry. 1994 Sep-Oct; 35(5):373-81.
    View in: PubMed
  59. Pitman RK, Orr SP, Lasko NB. Effects of intranasal vasopressin and oxytocin on physiologic responding during personal combat imagery in Vietnam veterans with posttraumatic stress disorder. Psychiatry Res. 1993 Aug; 48(2):107-17.
    View in: PubMed
  60. Orr SP, Pitman RK, Lasko NB, Herz LR. Psychophysiological assessment of posttraumatic stress disorder imagery in World War II and Korean combat veterans. J Abnorm Psychol. 1993 Feb; 102(1):152-9.
    View in: PubMed
  61. Gurvits TV, Lasko NB, Schachter SC, Kuhne AA, Orr SP, Pitman RK. Neurological status of Vietnam veterans with chronic posttraumatic stress disorder. J Neuropsychiatry Clin Neurosci. 1993; 5(2):183-8.
    View in: PubMed
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