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Keywords
Last Name
Institution

Joan Siefert Brugge, Ph.D.

TitleLouise Foote Pfeiffer Professor of Cell Biology
InstitutionHarvard Medical School
DepartmentCell Biology
AddressHarvard Medical School
Dept of Cell Biology, Building C1, Room 513A
240 Longwood Ave
Boston MA 02115
Phone617/432-3974
Fax617/432-3969
Other Positions
TitleHead of the Department of Cell Biology
InstitutionHarvard Medical School
DepartmentCell Biology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Albeck JG, Mills GB, Brugge JS. Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals. Mol Cell. 2013 Jan 24; 49(2):249-61.
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  2. Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS. Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell. 2012 Nov 13; 22(5):615-30.
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  3. Ng MR, Besser A, Danuser G, Brugge JS. Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility. J Cell Biol. 2012 Oct 29; 199(3):545-63.
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  4. Brugge JS. Into the deep: Refocusing on 3D. Nat Cell Biol. 2012; 14(4):332.
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  5. Worster DT, Schmelzle T, Solimini NL, Lightcap ES, Millard B, Mills GB, Brugge JS, Albeck JG. Akt and ERK control the proliferative response of mammary epithelial cells to the growth factors IGF-1 and EGF through the cell cycle inhibitor p57Kip2. Sci Signal. 2012 Mar 6; 5(214):ra19.
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  6. Davidowitz RA, Iwanicki MP, Brugge JS. In vitro mesothelial clearance assay that models the early steps of ovarian cancer metastasis. J Vis Exp. 2012; (60).
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  7. Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB, Brugge JS. Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells. Cancer Cell. 2012 Feb 14; 21(2):227-39.
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  8. Leung CT, Brugge JS. Outgrowth of single oncogene-expressing cells from suppressive epithelial environments. Nature. 2012 Feb 16; 482(7385):410-3.
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  9. Grassian AR, Coloff JL, Brugge JS. Extracellular matrix regulation of metabolism and implications for tumorigenesis. Cold Spring Harb Symp Quant Biol. 2011; 76:313-24.
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  10. Wang L, Brugge JS, Janes KA. Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression. Proc Natl Acad Sci U S A. 2011 Oct 4; 108(40):E803-12.
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  11. Grassian AR, Metallo CM, Coloff JL, Stephanopoulos G, Brugge JS. Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation. Genes Dev. 2011 Aug 15; 25(16):1716-33.
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  12. Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet. 2011 Sep; 43(9):869-74.
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  13. Iwanicki MP, Davidowitz RA, Ng MR, Besser A, Muranen T, Merritt M, Danuser G, Ince T, Brugge JS. Ovarian cancer spheroids use myosin-generated force to clear the mesothelium. Cancer Discov. 2011 Jul; 1(2):144-57.
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  14. Gallegos L, Ng MR, Brugge JS. The myosin-II-responsive focal adhesion proteome: a tour de force? Nat Cell Biol. 2011 Apr; 13(4):344-6.
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  15. Kim JH, Cho A, Yin H, Schafer DA, Mouneimne G, Simpson KJ, Nguyen KV, Brugge JS, Montell DJ. Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Genes Dev. 2011 Apr 1; 25(7):730-41.
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  16. Albeck JG, Brugge JS. Uncovering a tumor suppressor for triple-negative breast cancers. Cell. 2011 Mar 4; 144(5):638-40.
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  17. Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, Overholtzer M. A non-genetic route to aneuploidy in human cancers. Nat Cell Biol. 2011 Mar; 13(3):324-30.
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  18. Harrison SC, Brugge JS. Mechanistic biology in the next quarter century. Mol Biol Cell. 2010 Nov 15; 21(22):3799-800.
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  19. Knowlton ML, Selfors LM, Wrobel CN, Gu TL, Ballif BA, Gygi SP, Polakiewicz R, Brugge JS. Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells. PLoS One. 2010; 5(10):e13587.
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  20. Grassian AR, Schafer ZT, Brugge JS. ErbB2 stabilizes epidermal growth factor receptor (EGFR) expression via Erk and Sprouty2 in extracellular matrix-detached cells. J Biol Chem. 2011 Jan 7; 286(1):79-90.
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  21. Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, Brugge JS. PTK6 regulates IGF-1-induced anchorage-independent survival. PLoS One. 2010; 5(7):e11729.
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  22. Brugge J. Joan Brugge: running rings around cancer. Text by Caitlin Sedwick. J Cell Biol. 2010 Jun 14; 189(6):922-3.
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  23. Tushir JS, Clancy J, Warren A, Wrobel C, Brugge JS, D'Souza-Schorey C. Unregulated ARF6 activation in epithelial cysts generates hyperactive signaling endosomes and disrupts morphogenesis. Mol Biol Cell. 2010 Jul 1; 21(13):2355-66.
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  24. Zhou W, Hur W, McDermott U, Dutt A, Xian W, Ficarro SB, Zhang J, Sharma SV, Brugge J, Meyerson M, Settleman J, Gray NS. A structure-guided approach to creating covalent FGFR inhibitors. Chem Biol. 2010 Mar 26; 17(3):285-95.
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  25. Janes KA, Wang CC, Holmberg KJ, Cabral K, Brugge JS. Identifying single-cell molecular programs by stochastic profiling. Nat Methods. 2010 Apr; 7(4):311-7.
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  26. Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS. Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5012-7.
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  27. Wolfer A, Wittner BS, Irimia D, Flavin RJ, Lupien M, Gunawardane RN, Meyer CA, Lightcap ES, Tamayo P, Mesirov JP, Liu XS, Shioda T, Toner M, Loda M, Brown M, Brugge JS, Ramaswamy S. MYC regulation of a "poor-prognosis" metastatic cancer cell state. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3698-703.
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  28. Muller PA, Caswell PT, Doyle B, Iwanicki MP, Tan EH, Karim S, Lukashchuk N, Gillespie DA, Ludwig RL, Gosselin P, Cromer A, Brugge JS, Sansom OJ, Norman JC, Vousden KH. Mutant p53 drives invasion by promoting integrin recycling. Cell. 2009 Dec 24; 139(7):1327-41.
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  29. Leung CT, Brugge JS. Tumor self-seeding: bidirectional flow of tumor cells. Cell. 2009 Dec 24; 139(7):1226-8.
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  30. Ng MR, Brugge JS. A stiff blow from the stroma: collagen crosslinking drives tumor progression. Cancer Cell. 2009 Dec 8; 16(6):455-7.
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  31. Iwanicki MP, Brugge JS. Transcriptional regulation of metastatic [Id]entity by KLF17. Genome Biol. 2009; 10(11):244.
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  32. Zhang J, Ji JY, Yu M, Overholtzer M, Smolen GA, Wang R, Brugge JS, Dyson NJ, Haber DA. YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol. 2009 Dec; 11(12):1444-50.
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  33. Konecny GE, Glas R, Dering J, Manivong K, Qi J, Finn RS, Yang GR, Hong KL, Ginther C, Winterhoff B, Gao G, Brugge J, Slamon DJ. Activity of the multikinase inhibitor dasatinib against ovarian cancer cells. Br J Cancer. 2009 Nov 17; 101(10):1699-708.
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  34. Schafer ZT, Grassian AR, Song L, Jiang Z, Gerhart-Hines Z, Irie HY, Gao S, Puigserver P, Brugge JS. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature. 2009 Sep 3; 461(7260):109-13.
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  35. Mouneimne G, Brugge JS. YB-1 translational control of epithelial-mesenchyme transition. Cancer Cell. 2009 May 5; 15(5):357-9.
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  36. Xian W, Pappas L, Pandya D, Selfors LM, Derksen PW, de Bruin M, Gray NS, Jonkers J, Rosen JM, Brugge JS. Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival. Cancer Res. 2009 Mar 15; 69(6):2244-51.
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  37. Overholtzer M, Brugge JS. The cell biology of cell-in-cell structures. Nat Rev Mol Cell Biol. 2008 Oct; 9(10):796-809.
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  38. Simpson KJ, Selfors LM, Bui J, Reynolds A, Leake D, Khvorova A, Brugge JS. Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nat Cell Biol. 2008 Sep; 10(9):1027-38.
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  39. Melani M, Simpson KJ, Brugge JS, Montell D. Regulation of cell adhesion and collective cell migration by hindsight and its human homolog RREB1. Curr Biol. 2008 Apr 8; 18(7):532-7.
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  40. Mailleux AA, Overholtzer M, Brugge JS. [Entosis, a cell death process related to cell cannibalism between tumor cells]. Med Sci (Paris). 2008 Mar; 24(3):246-8.
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  41. Tamimi RM, Brugge JS, Freedman ML, Miron A, Iglehart JD, Colditz GA, Hankinson SE. Circulating colony stimulating factor-1 and breast cancer risk. Cancer Res. 2008 Jan 1; 68(1):18-21.
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  42. Schafer ZT, Brugge JS. IL-6 involvement in epithelial cancers. J Clin Invest. 2007 Dec; 117(12):3660-3.
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  43. Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell. 2007 Nov 30; 131(5):966-79.
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  44. Mailleux AA, Overholtzer M, Brugge JS. Lumen formation during mammary epithelial morphogenesis: insights from in vitro and in vivo models. Cell Cycle. 2008 Jan 1; 7(1):57-62.
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  45. Fischbach C, Chen R, Matsumoto T, Schmelzle T, Brugge JS, Polverini PJ, Mooney DJ. Engineering tumors with 3D scaffolds. Nat Methods. 2007 Oct; 4(10):855-60.
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  46. Mouneimne G, Brugge JS. Tensins: a new switch in cell migration. Dev Cell. 2007 Sep; 13(3):317-9.
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  47. Brugge J, Hung MC, Mills GB. A new mutational AKTivation in the PI3K pathway. Cancer Cell. 2007 Aug; 12(2):104-7.
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  48. Miller-Jensen K, Janes KA, Brugge JS, Lauffenburger DA. Common effector processing mediates cell-specific responses to stimuli. Nature. 2007 Aug 2; 448(7153):604-8.
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  49. Schmelzle T, Mailleux AA, Overholtzer M, Carroll JS, Solimini NL, Lightcap ES, Veiby OP, Brugge JS. Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis. Proc Natl Acad Sci U S A. 2007 Mar 6; 104(10):3787-92.
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  50. Mailleux AA, Overholtzer M, Schmelzle T, Bouillet P, Strasser A, Brugge JS. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell. 2007 Feb; 12(2):221-34.
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  51. Carroll DK, Brugge JS, Attardi LD. p63, cell adhesion and survival. Cell Cycle. 2007 Feb 1; 6(3):255-61.
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  52. Walker SJ, Brugge JS. SePARating polarity and proliferation in ErbB2 oncogenesis. Nat Cell Biol. 2006 Nov; 8(11):1220-2.
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  53. Overholtzer M, Zhang J, Smolen GA, Muir B, Li W, Sgroi DC, Deng CX, Brugge JS, Haber DA. Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon. Proc Natl Acad Sci U S A. 2006 Aug 15; 103(33):12405-10.
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  54. Carroll DK, Carroll JS, Leong CO, Cheng F, Brown M, Mills AA, Brugge JS, Ellisen LW. p63 regulates an adhesion programme and cell survival in epithelial cells. Nat Cell Biol. 2006 Jun; 8(6):551-61.
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  55. Wilsbacher JL, Moores SL, Brugge JS. An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligand. Cell Commun Signal. 2006; 4:5.
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  56. Witt AE, Hines LM, Collins NL, Hu Y, Gunawardane RN, Moreira D, Raphael J, Jepson D, Koundinya M, Rolfs A, Taron B, Isakoff SJ, Brugge JS, LaBaer J. Functional proteomics approach to investigate the biological activities of cDNAs implicated in breast cancer. J Proteome Res. 2006 Mar; 5(3):599-610.
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  57. Hall AB, Gakidis MA, Glogauer M, Wilsbacher JL, Gao S, Swat W, Brugge JS. Requirements for Vav guanine nucleotide exchange factors and Rho GTPases in FcgammaR- and complement-mediated phagocytosis. Immunity. 2006 Mar; 24(3):305-16.
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  58. Irie HY, Pearline RV, Grueneberg D, Hsia M, Ravichandran P, Kothari N, Natesan S, Brugge JS. Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition. J Cell Biol. 2005 Dec 19; 171(6):1023-34.
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  59. Gunawardane RN, Sgroi DC, Wrobel CN, Koh E, Daley GQ, Brugge JS. Novel role for PDEF in epithelial cell migration and invasion. Cancer Res. 2005 Dec 15; 65(24):11572-80.
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  60. Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, Cantley LC, Brugge JS. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res. 2005 Dec 1; 65(23):10992-1000.
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  61. Yan SR, Joseph RR, Rosen K, Reginato MJ, Jackson A, Allaire N, Brugge JS, Jobin C, Stadnyk AW. Activation of NF-kappaB following detachment delays apoptosis in intestinal epithelial cells. Oncogene. 2005 Sep 29; 24(43):6482-91.
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  62. Debnath J, Brugge JS. Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer. 2005 Sep; 5(9):675-88.
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  63. Collins NL, Reginato MJ, Paulus JK, Sgroi DC, Labaer J, Brugge JS. G1/S cell cycle arrest provides anoikis resistance through Erk-mediated Bim suppression. Mol Cell Biol. 2005 Jun; 25(12):5282-91.
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  64. Reginato MJ, Mills KR, Becker EB, Lynch DK, Bonni A, Muthuswamy SK, Brugge JS. Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol. 2005 Jun; 25(11):4591-601.
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  65. Cowan CW, Shao YR, Sahin M, Shamah SM, Lin MZ, Greer PL, Gao S, Griffith EC, Brugge JS, Greenberg ME. Vav family GEFs link activated Ephs to endocytosis and axon guidance. Neuron. 2005 Apr 21; 46(2):205-17.
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  66. Bill HM, Knudsen B, Moores SL, Muthuswamy SK, Rao VR, Brugge JS, Miranti CK. Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol. 2004 Oct; 24(19):8586-99.
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  67. Shaw KR, Wrobel CN, Brugge JS. Use of three-dimensional basement membrane cultures to model oncogene-induced changes in mammary epithelial morphogenesis. J Mammary Gland Biol Neoplasia. 2004 Oct; 9(4):297-310.
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  68. Gakidis MA, Cullere X, Olson T, Wilsbacher JL, Zhang B, Moores SL, Ley K, Swat W, Mayadas T, Brugge JS. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol. 2004 Jul 19; 166(2):273-82.
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  69. Martin SS, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS, Leder P. A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene. 2004 Jun 3; 23(26):4641-5.
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  70. Ma XJ, Wang Z, Ryan PD, Isakoff SJ, Barmettler A, Fuller A, Muir B, Mohapatra G, Salunga R, Tuggle JT, Tran Y, Tran D, Tassin A, Amon P, Wang W, Wang W, Enright E, Stecker K, Estepa-Sabal E, Smith B, Younger J, Balis U, Michaelson J, Bhan A, Habin K, Baer TM, Brugge J, Haber DA, Erlander MG, Sgroi DC. A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell. 2004 Jun; 5(6):607-16.
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  71. Seton-Rogers SE, Brugge JS. ErbB2 and TGF-beta: a cooperative role in mammary tumor progression? Cell Cycle. 2004 May; 3(5):597-600.
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  72. Wrobel CN, Debnath J, Lin E, Beausoleil S, Roussel MF, Brugge JS. Autocrine CSF-1R activation promotes Src-dependent disruption of mammary epithelial architecture. J Cell Biol. 2004 Apr 26; 165(2):263-73.
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  73. Mills KR, Reginato M, Debnath J, Queenan B, Brugge JS. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci U S A. 2004 Mar 9; 101(10):3438-43.
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  74. Seton-Rogers SE, Lu Y, Hines LM, Koundinya M, LaBaer J, Muthuswamy SK, Brugge JS. Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proc Natl Acad Sci U S A. 2004 Feb 3; 101(5):1257-62.
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  75. Seton-Rogers SE, Lu Y, Hines L, Koundinya M, LaBaer J, Muthuswamy SK and Brugge JS . Coooperation of ErbB2 and TGF-B in induction of migration and invasion in mammary epithelial cells. Proc Natl Acad Sci USA. 2004; (101):1257-62.
  76. Miranti CK, Bill HM, Moores SL, Muthuswamy SK, Rao VR and Brugge JS. Epidermal growth factor receptor regulation of integrin signaling and cell cycle entry in epithelial cells. Journal of Cell Biology, in press,. 2004.
  77. Martin S, Ridgeway AG, Pinkas J, Lu Y, Reginato MJ, Koh EY, Michelman M, Daley GQ, Brugge JS and Leder P. A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth. Oncogene, in press,. 2004.
  78. Mills KR, Reginato M, Debnath J, Queenan B and Brugge JS. TRAIL is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci USA. 2004; (101):3438-43.
  79. Reginato MJ, Mills KR, Paulus JK, Debnath J, Muthuswamy SK and Brugge JS. Bim regulation of lumen formation in mammary epithelial acini is blocked by oncogenes. Submitted,. 2004.
  80. Martinez Gakidis MA, Cullere X, Olson W, Wilsbacher JL, Zhang B, Moores SL, Ley K, Swat W, Mayadas T and Brugge JS. Vav GEFs are required for b2 integrin-dependent functions of neutrophils. Submitted,. 2004.
  81. Fujikawa K, Miletic AV, Alt FW, Faccio R, Brown T, Hoog J, Fredericks J, Nishi S, Mildiner S, Moores SL, Brugge J, Rosen FS, Swat W. Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med. 2003 Nov 17; 198(10):1595-608.
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  82. Arias-Salgado EG, Lizano S, Sarkar S, Brugge JS, Ginsberg MH, Shattil SJ. Src kinase activation by direct interaction with the integrin beta cytoplasmic domain. Proc Natl Acad Sci U S A. 2003 Nov 11; 100(23):13298-302.
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  83. Debnath J, Walker SJ, Brugge JS. Akt activation disrupts mammary acinar architecture and enhances proliferation in an mTOR-dependent manner. J Cell Biol. 2003 Oct 27; 163(2):315-26.
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  84. Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol. 2003 Aug; 5(8):733-40.
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  85. Gozani O, Karuman P, Jones DR, Ivanov D, Cha J, Lugovskoy AA, Baird CL, Zhu H, Field SJ, Lessnick SL, Villasenor J, Mehrotra B, Chen J, Rao VR, Brugge JS, Ferguson CG, Payrastre B, Myszka DG, Cantley LC, Wagner G, Divecha N, Prestwich GD, Yuan J. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell. 2003 Jul 11; 114(1):99-111.
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  86. Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods. 2003 Jul; 30(3):256-68.
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  87. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6.
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  88. Debnath J, Mills KR, Collins NL, Reginato MJ, Muthuswamy SK, Brugge JS. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell. 2002 Oct 4; 111(1):29-40.
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  89. Chaudhary A, Brugge JS, Cooper JA. Direct phosphorylation of focal adhesion kinase by c-Src: evidence using a modified nucleotide pocket kinase and ATP analog. Biochem Biophys Res Commun. 2002 Jun 7; 294(2):293-300.
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  90. Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores SL, Brugge JS, Lowell CA, Shattil SJ. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol. 2002 Apr 15; 157(2):265-75.
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  91. Miranti CK, Brugge JS. Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol. 2002 Apr; 4(4):E83-90.
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  92. Woodside DG, Obergfell A, Leng L, Wilsbacher JL, Miranti CK, Brugge JS, Shattil SJ, Ginsberg MH. Activation of Syk protein tyrosine kinase through interaction with integrin beta cytoplasmic domains. Curr Biol. 2001 Nov 13; 11(22):1799-804.
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  93. Muthuswamy SK, Li D, Lelievre S, Bissell MJ, Brugge JS. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol. 2001 Sep; 3(9):785-92.
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  94. Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W. Vav family proteins couple to diverse cell surface receptors. Mol Cell Biol. 2000 Sep; 20(17):6364-73.
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  95. Chaudhary A, King WG, Mattaliano MD, Frost JA, Diaz B, Morrison DK, Cobb MH, Marshall MS, Brugge JS. Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr Biol. 2000 May 4; 10(9):551-4.
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  96. Rao VR, Corradetti MN, Chen J, Peng J, Yuan J, Prestwich GD, Brugge JS. Expression cloning of protein targets for 3-phosphorylated phosphoinositides. J Biol Chem. 1999 Dec 31; 274(53):37893-900.
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  97. Muthuswamy SK, Gilman M, Brugge JS. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. Mol Cell Biol. 1999 Oct; 19(10):6845-57.
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  98. Miranti CK, Ohno S, Brugge JS. Protein kinase C regulates integrin-induced activation of the extracellular regulated kinase pathway upstream of Shc. J Biol Chem. 1999 Apr 9; 274(15):10571-81.
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  99. Lee RJ, Albanese C, Stenger RJ, Watanabe G, Inghirami G, Haines GK, Webster M, Muller WJ, Brugge JS, Davis RJ, Pestell RG. pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) signaling in breast cancer cells. J Biol Chem. 1999 Mar 12; 274(11):7341-50.
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  100. Miranti CK, Leng L, Maschberger P, Brugge JS, Shattil SJ. Identification of a novel integrin signaling pathway involving the kinase Syk and the guanine nucleotide exchange factor Vav1. Curr Biol. 1998 Dec 3; 8(24):1289-99.
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  101. Brugge JS. Casting light on focal adhesions. Nat Genet. 1998 Aug; 19(4):309-11.
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  102. Clark EA, King WG, Brugge JS, Symons M, Hynes RO. Integrin-mediated signals regulated by members of the rho family of GTPases. J Cell Biol. 1998 Jul 27; 142(2):573-86.
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  103. Gao J, Zoller KE, Ginsberg MH, Brugge JS, Shattil SJ. Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3. EMBO J. 1997 Nov 3; 16(21):6414-25.
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  104. King WG, Mattaliano MD, Chan TO, Tsichlis PN, Brugge JS. Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation. Mol Cell Biol. 1997 Aug; 17(8):4406-18.
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  105. Zoller KE, MacNeil IA, Brugge JS. Protein tyrosine kinases Syk and ZAP-70 display distinct requirements for Src family kinases in immune response receptor signal transduction. J Immunol. 1997 Feb 15; 158(4):1650-9.
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  106. Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol. 1997; 13:513-609.
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  107. Bolen JB, Brugge JS. Leukocyte protein tyrosine kinases: potential targets for drug discovery. Annu Rev Immunol. 1997; 15:371-404.
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  108. Cichowski K, Brugge JS, Brass LF. Thrombin receptor activation and integrin engagement stimulate tyrosine phosphorylation of the proto-oncogene product, p95vav, in platelets. J Biol Chem. 1996 Mar 29; 271(13):7544-50.
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  109. Rusanescu G, Qi H, Thomas SM, Brugge JS, Halegoua S. Calcium influx induces neurite growth through a Src-Ras signaling cassette. Neuron. 1995 Dec; 15(6):1415-25.
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  110. Rickles RJ, Botfield MC, Zhou XM, Henry PA, Brugge JS, Zoller MJ. Phage display selection of ligand residues important for Src homology 3 domain binding specificity. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):10909-13.
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  111. Weng Z, Rickles RJ, Feng S, Richard S, Shaw AS, Schreiber SL, Brugge JS. Structure-function analysis of SH3 domains: SH3 binding specificity altered by single amino acid substitutions. Mol Cell Biol. 1995 Oct; 15(10):5627-34.
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  112. Mukhopadhyay D, Tsiokas L, Zhou XM, Foster D, Brugge JS, Sukhatme VP. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature. 1995 Jun 15; 375(6532):577-81.
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  113. Shiue L, Zoller MJ, Brugge JS. Syk is activated by phosphotyrosine-containing peptides representing the tyrosine-based activation motifs of the high affinity receptor for IgE. J Biol Chem. 1995 May 5; 270(18):10498-502.
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  114. Clark EA, Brugge JS. Integrins and signal transduction pathways: the road taken. Science. 1995 Apr 14; 268(5208):233-9.
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  115. Rivera VM, Brugge JS. Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells. Mol Cell Biol. 1995 Mar; 15(3):1582-90.
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  116. Rickles RJ, Botfield MC, Weng Z, Taylor JA, Green OM, Brugge JS, Zoller MJ. Identification of Src, Fyn, Lyn, PI3K and Abl SH3 domain ligands using phage display libraries. EMBO J. 1994 Dec 1; 13(23):5598-604.
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  117. Clark EA, Shattil SJ, Ginsberg MH, Bolen J, Brugge JS. Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3. J Biol Chem. 1994 Nov 18; 269(46):28859-64.
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  118. Clark EA, Shattil SJ, Brugge JS. Regulation of protein tyrosine kinases in platelets. Trends Biochem Sci. 1994 Nov; 19(11):464-9.
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  119. Shattil SJ, Ginsberg MH, Brugge JS. Adhesive signaling in platelets. Curr Opin Cell Biol. 1994 Oct; 6(5):695-704.
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  120. Clark EA, Trikha M, Markland FS, Brugge JS. Structurally distinct disintegrins contortrostatin and multisquamatin differentially regulate platelet tyrosine phosphorylation. J Biol Chem. 1994 Sep 2; 269(35):21940-3.
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  121. Weng Z, Thomas SM, Rickles RJ, Taylor JA, Brauer AW, Seidel-Dugan C, Michael WM, Dreyfuss G, Brugge JS. Identification of Src, Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains. Mol Cell Biol. 1994 Jul; 14(7):4509-21.
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  122. Shattil SJ, Haimovich B, Cunningham M, Lipfert L, Parsons JT, Ginsberg MH, Brugge JS. Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors. J Biol Chem. 1994 May 20; 269(20):14738-45.
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  123. Fox JE, Lipfert L, Clark EA, Reynolds CC, Austin CD, Brugge JS. On the role of the platelet membrane skeleton in mediating signal transduction. Association of GP IIb-IIIa, pp60c-src, pp62c-yes, and the p21ras GTPase-activating protein with the membrane skeleton. J Biol Chem. 1993 Dec 5; 268(34):25973-84.
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  124. Thomas JE, Aguzzi A, Soriano P, Wagner EF, Brugge JS. Induction of tumor formation and cell transformation by polyoma middle T antigen in the absence of Src. Oncogene. 1993 Sep; 8(9):2521-9.
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  125. Lynch SA, Brugge JS, Fromowitz F, Glantz L, Wang P, Caruso R, Viola MV. Increased expression of the src proto-oncogene in hairy cell leukemia and a subgroup of B-cell lymphomas. Leukemia. 1993 Sep; 7(9):1416-22.
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  126. Haimovich B, Lipfert L, Brugge JS, Shattil SJ. Tyrosine phosphorylation and cytoskeletal reorganization in platelets are triggered by interaction of integrin receptors with their immobilized ligands. J Biol Chem. 1993 Jul 25; 268(21):15868-77.
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  127. Weng Z, Taylor JA, Turner CE, Brugge JS, Seidel-Dugan C. Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells. J Biol Chem. 1993 Jul 15; 268(20):14956-63.
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  128. Huang MM, Lipfert L, Cunningham M, Brugge JS, Ginsberg MH, Shattil SJ. Adhesive ligand binding to integrin alpha IIb beta 3 stimulates tyrosine phosphorylation of novel protein substrates before phosphorylation of pp125FAK. J Cell Biol. 1993 Jul; 122(2):473-83.
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  129. Brugge JS. New intracellular targets for therapeutic drug design. Science. 1993 May 14; 260(5110):918-9.
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  130. Clark EA, Brugge JS. Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets. Mol Cell Biol. 1993 Mar; 13(3):1863-71.
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  131. Rozakis-Adcock M, McGlade J, Mbamalu G, Pelicci G, Daly R, Li W, Batzer A, Thomas S, Brugge J, Pelicci PG, et al. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature. 1992 Dec 17; 360(6405):689-92.
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  132. Yu H, Rosen MK, Shin TB, Seidel-Dugan C, Brugge JS, Schreiber SL. Solution structure of the SH3 domain of Src and identification of its ligand-binding site. Science. 1992 Dec 4; 258(5088):1665-8.
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  133. Lipfert L, Haimovich B, Schaller MD, Cobb BS, Parsons JT, Brugge JS. Integrin-dependent phosphorylation and activation of the protein tyrosine kinase pp125FAK in platelets. J Cell Biol. 1992 Nov; 119(4):905-12.
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  134. Maroney AC, Qureshi SA, Foster DA, Brugge JS. Cloning and characterization of a thermolabile v-src gene for use in reversible transformation of mammalian cells. Oncogene. 1992 Jun; 7(6):1207-14.
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  135. Seidel-Dugan C, Meyer BE, Thomas SM, Brugge JS. Effects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src. Mol Cell Biol. 1992 Apr; 12(4):1835-45.
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  136. Thomas SM, DeMarco M, D'Arcangelo G, Halegoua S, Brugge JS. Ras is essential for nerve growth factor- and phorbol ester-induced tyrosine phosphorylation of MAP kinases. Cell. 1992 Mar 20; 68(6):1031-40.
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  137. Cichowski K, McCormick F, Brugge JS. p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets. J Biol Chem. 1992 Mar 15; 267(8):5025-8.
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  138. Huang MM, Indik Z, Brass LF, Hoxie JA, Schreiber AD, Brugge JS. Activation of Fc gamma RII induces tyrosine phosphorylation of multiple proteins including Fc gamma RII. J Biol Chem. 1992 Mar 15; 267(8):5467-73.
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  139. Schmidt JW, Brugge JS, Nelson WJ. pp60src tyrosine kinase modulates P19 embryonal carcinoma cell fate by inhibiting neuronal but not epithelial differentiation. J Cell Biol. 1992 Feb; 116(4):1019-33.
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  140. Kremer NE, D'Arcangelo G, Thomas SM, DeMarco M, Brugge JS, Halegoua S. Signal transduction by nerve growth factor and fibroblast growth factor in PC12 cells requires a sequence of src and ras actions. J Cell Biol. 1991 Nov; 115(3):809-19.
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  141. Thomas JE, Soriano P, Brugge JS. Phosphorylation of c-Src on tyrosine 527 by another protein tyrosine kinase. Science. 1991 Oct 25; 254(5031):568-71.
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  142. Shattil SJ, Brugge JS. Protein tyrosine phosphorylation and the adhesive functions of platelets. Curr Opin Cell Biol. 1991 Oct; 3(5):869-79.
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  143. Lord KA, Abdollahi A, Thomas SM, DeMarco M, Brugge JS, Hoffman-Liebermann B, Liebermann DA. Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation. Mol Cell Biol. 1991 Sep; 11(9):4371-9.
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  144. Thomas SM, Hayes M, D'Arcangelo G, Armstrong RC, Meyer BE, Zilberstein A, Brugge JS, Halegoua S. Induction of neurite outgrowth by v-src mimics critical aspects of nerve growth factor-induced differentiation. Mol Cell Biol. 1991 Sep; 11(9):4739-50.
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  145. Huang MM, Bolen JB, Barnwell JW, Shattil SJ, Brugge JS. Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. Proc Natl Acad Sci U S A. 1991 Sep 1; 88(17):7844-8.
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  146. Dorai T, Levy JB, Kang L, Brugge JS, Wang LH. Analysis of cDNAs of the proto-oncogene c-src: heterogeneity in 5' exons and possible mechanism for the genesis of the 3' end of v-src. Mol Cell Biol. 1991 Aug; 11(8):4165-76.
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  147. Brugge J, Curran T, Harlow E, McCormick F. . Origins of Human Cancer: A Comprehensive Review. 1991; 1-883.
  148. Golden A, Brugge JS, Shattil SJ. Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins. J Cell Biol. 1990 Dec; 111(6 Pt 2):3117-27.
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  149. Filson AJ, Azarnia R, Beyer EC, Loewenstein WR, Brugge JS. Tyrosine phosphorylation of a gap junction protein correlates with inhibition of cell-to-cell communication. Cell Growth Differ. 1990 Dec; 1(12):661-8.
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  150. Mitchell CA, Jefferson AB, Bejeck BE, Brugge JS, Deuel TF, Majerus PW. Thrombin-stimulated immunoprecipitation of phosphatidylinositol 3-kinase from human platelets. Proc Natl Acad Sci U S A. 1990 Dec; 87(23):9396-400.
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  151. Sugrue MM, Brugge JS, Marshak DR, Greengard P, Gustafson EL. Immunocytochemical localization of the neuron-specific form of the c-src gene product, pp60c-src(+), in rat brain. J Neurosci. 1990 Aug; 10(8):2513-27.
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  152. Ferracini R, Brugge J. Analysis of mutant forms of the c-src gene product containing a phenylalanine substitution for tyrosine 416. Oncogene Res. 1990; 5(3):205-19.
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  153. Levy JB, Brugge JS. Biological and biochemical properties of the c-src+ gene product overexpressed in chicken embryo fibroblasts. Mol Cell Biol. 1989 Aug; 9(8):3332-41.
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  154. Nemeth SP, Fox LG, DeMarco M, Brugge JS. Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein. Mol Cell Biol. 1989 Mar; 9(3):1109-19.
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  155. Golden A, Brugge JS. Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets. Proc Natl Acad Sci U S A. 1989 Feb; 86(3):901-5.
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  156. Lundy J, Chen J, Wang P, Fromowitz F, Schuss A, Lynch S, Brugge J, Viola MV. Phenotypic and genetic alterations in pre-cancerous cells in the colon. Anticancer Res. 1988 Sep-Oct; 8(5A):1005-13.
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  157. Schuh SM, Brugge JS. Investigation of factors that influence phosphorylation of pp60c-src on tyrosine 527. Mol Cell Biol. 1988 Jun; 8(6):2465-71.
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  158. Walaas SI, Lustig A, Greengard P, Brugge JS. Widespread distribution of the c-src gene product in nerve cells and axon terminals in the adult rat brain. Brain Res. 1988 Jun; 427(3):215-22.
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  159. Levy JB, Dorai T, Wang LH, Brugge JS. The structurally distinct form of pp60c-src detected in neuronal cells is encoded by a unique c-src mRNA. Mol Cell Biol. 1987 Nov; 7(11):4142-5.
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  160. Brugge JS, Jarosik G, Andersen J, Queral-Lustig A, Fedor-Chaiken M, Broach JR. Expression of Rous sarcoma virus transforming protein pp60v-src in Saccharomyces cerevisiae cells. Mol Cell Biol. 1987 Jun; 7(6):2180-7.
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  161. Brugge J, Cotton P, Lustig A, Yonemoto W, Lipsich L, Coussens P, Barrett JN, Nonner D, Keane RW. Characterization of the altered form of the c-src gene product in neuronal cells. Genes Dev. 1987 May; 1(3):287-96.
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  162. Yonemoto W, Filson AJ, Queral-Lustig AE, Wang JY, Brugge JS. Detection of phosphotyrosine-containing proteins in polyomavirus middle tumor antigen-transformed cells after treatment with a phosphotyrosine phosphatase inhibitor. Mol Cell Biol. 1987 Feb; 7(2):905-13.
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  163. Brugge J S, Yonemoto W, Lustig A and Golden A. . Investigations of the expression of the cellular src gene product. Oncogenes and Cancer. 1987; 241-252.
  164. Brugge JS, Lustig A, Messer A. Changes in the pattern of expression of pp60c-src in cerebellar mutants of mice. J Neurosci Res. 1987; 18(4):532-8.
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  165. Lynch SA, Brugge JS, Levine JM. Induction of altered c-src product during neural differentiation of embryonal carcinoma cells. Science. 1986 Nov 14; 234(4778):873-6.
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  166. Brugge JS. The p35/p36 substrates of protein-tyrosine kinases as inhibitors of phospholipase A2. Cell. 1986 Jul 18; 46(2):149-50.
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  167. Golden A, Nemeth SP, Brugge JS. Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity. Proc Natl Acad Sci U S A. 1986 Feb; 83(4):852-6.
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  168. Brugge JS, Yonemoto W, Lustig A, Golden A. Investigations of the expression of the cellular src gene product. Princess Takamatsu Symp. 1986; 17:241-9.
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  169. Brugge JS. Interaction of the Rous sarcoma virus protein pp60src with the cellular proteins pp50 and pp90. Curr Top Microbiol Immunol. 1986; 123:1-22.
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  170. Schuh S, Yonemoto W, Brugge J, Bauer VJ, Riehl RM, Sullivan WP, Toft DO. A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src. J Biol Chem. 1985 Nov 15; 260(26):14292-6.
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  171. Brugge JS, Cotton PC, Queral AE, Barrett JN, Nonner D, Keane RW. Neurones express high levels of a structurally modified, activated form of pp60c-src. Nature. 1985 Aug 8-14; 316(6028):554-7.
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  172. Yonemoto W, Jarvis-Morar M, Brugge JS, Bolen JB, Israel MA. Tyrosine phosphorylation within the amino-terminal domain of pp60c-src molecules associated with polyoma virus middle-sized tumor antigen. Proc Natl Acad Sci U S A. 1985 Jul; 82(14):4568-72.
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  173. Bolen JB, Thiele CJ, Israel MA, Yonemoto W, Lipsich LA, Brugge JS. Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation. Cell. 1984 Oct; 38(3):767-77.
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  174. Chinkers M, Brugge JS. Characterization of structural domains of the human epidermal growth factor receptor obtained by partial proteolysis. J Biol Chem. 1984 Sep 25; 259(18):11534-42.
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  175. Hughes S, Mellstrom K, Kosik E, Tamanoi F, Brugge J. Mutation of a termination codon affects src initiation. Mol Cell Biol. 1984 Sep; 4(9):1738-46.
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  176. Lipsich L, Brugge JS, Boettiger D. Expression of the Rous sarcoma virus src gene in avian macrophages fails to elicit transformed cell phenotype. Mol Cell Biol. 1984 Jul; 4(7):1420-4.
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  177. Keane RW, Lipsich LA, Brugge JS. Differentiation and transformation of neural plate cells. Dev Biol. 1984 May; 103(1):38-52.
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  178. Brugge JS, Darrow D. Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins. J Biol Chem. 1984 Apr 10; 259(7):4550-7.
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  179. Lipsich LA, Lewis AJ, Brugge JS. Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses. J Virol. 1983 Nov; 48(2):352-60.
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  180. Cotton PC, Brugge JS. Neural tissues express high levels of the cellular src gene product pp60c-src. Mol Cell Biol. 1983 Jun; 3(6):1157-62.
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  181. Brugge J, Yonemoto W, Darrow D. Interaction between the Rous sarcoma virus transforming protein and two cellular phosphoproteins: analysis of the turnover and distribution of this complex. Mol Cell Biol. 1983 Jan; 3(1):9-19.
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  182. Brugge JS, Darrow D, Lipsich LA, Yonemoto W. The association of the transforming protein of Rous sarcoma virus with two cellular phosphoproteins. Prog Clin Biol Res. 1983; 119:135-47.
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  183. Lanks KW, Kasambalides EJ, Chinkers M, Brugge JS. A major cytoplasmic glucose-regulated protein is associated with the Rous sarcoma virus pp60src protein. J Biol Chem. 1982 Aug 10; 257(15):8604-7.
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  184. Lipsich LA, Cutt JR, Brugge JS. Association of the transforming proteins of Rous, Fujinami, and Y73 avian sarcoma viruses with the same two cellular proteins. Mol Cell Biol. 1982 Jul; 2(7):875-80.
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  185. Brugge JS, Darrow D. Rous sarcoma virus-induced phosphorylation of a 50,000-molecular weight cellular protein. Nature. 1982 Jan 21; 295(5846):250-3.
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  186. Brugge JS, Erikson E, Erikson RL. The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins. Cell. 1981 Aug; 25(2):363-72.
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  187. Erikson RL, Purchio AF, Erikson E, Collett MS, Brugge JS. Molecular events in cells transformed by Rous Sarcoma virus. J Cell Biol. 1980 Nov; 87(2 Pt 1):319-25.
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  188. Erikson RI, Collett MS, Erikson E, Purchio AF, Brugge JS. Protein phosphorylation mediated by partially purified avian sarcoma virus transforming-gene product. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 2,:907-17.
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  189. Erikson RL, Collett MS, Erikson E, Purchio AF, Brugge JS. Transforming gene product of avian sarcoma viruses and its homolog in uninfected cells. Prog Clin Biol Res. 1980; 41:747-56.
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  190. Lau AF, Krzyzek RA, Brugge JS, Collett MS, Erikson RL, Faras AJ. Expression of the src-gene product, pp60src, in transformed and reverted mammalian cells infected with avian sarcoma virus. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 2,:1057-64.
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  191. Collett MS, Brugge JS, Erikson RL, Lau AF, Krzyzek RA, Faras AJ. The src gene product of transformed and morphologically reverted ASV-infected mammalian cells. Nature. 1979 Sep 20; 281(5728):195-8.
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  192. Lau AF, Krzyzek RA, Brugge JS, Erikson RL, Schollmeyer J, Faras AJ. Morphological revertants of an avian sarcoma virus-transformed mammalian cell line exhibit tumorigenicity and contain pp60src. Proc Natl Acad Sci U S A. 1979 Aug; 76(8):3904-8.
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  193. Collett MS, Erikson E, Purchio AF, Brugge JS, Erikson RL. A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product. Proc Natl Acad Sci U S A. 1979 Jul; 76(7):3159-63.
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  194. Brugge JS, Collett MS, Siddiqui A, Marczynska B, Deinhardt F, Erikson RL. Detection of the viral sarcoma gene product in cells infected with various strains of avian sarcoma virus and of a related protein in uninfected chicken cells. J Virol. 1979 Mar; 29(3):1196-203.
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  195. Erikson RL, Brugge JS, Erikson E, Collett MS. Studies on the structure and function of the avian sarcoma virus transforming gene product. Haematol Blood Transfus. 1979; 23:261-9.
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  196. Collett MS, Brugge JS, Erikson RL. Characterization of a normal avian cell protein related to the avian sarcoma virus transforming gene product. Cell. 1978 Dec; 15(4):1363-9.
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  197. Brugge JS, Steinbaugh PJ, Erikson RL. Characterization of the avian sarcoma virus protein p60src. Virology. 1978 Nov; 91(1):130-40.
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  198. Brugge J, Erikson E, Collett MS, Erikson RI. Peptide analysis of the transformation-specific antigen from avian sarcoma virus-transformed cells. J Virol. 1978 Jun; 26(3):773-82.
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  199. Purchio AF, Erikson E, Brugge JS, Erikson RL. Identification of a polypeptide encoded by the avian sarcoma virus src gene. Proc Natl Acad Sci U S A. 1978 Mar; 75(3):1567-71.
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  200. Brugge JS, Erikson E, Erikson RL. Antibody to virion structural proteins in mammals bearing avian sarcoma virus-induced tumors. Virology. 1978 Feb; 84(2):429-33.
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  201. Brugge JS, Purchio AF, Erikson RL. The distribution of virus-specific RNA in Rous sarcoma virus-induced hamster tumor cells. Virology. 1977 Nov; 83(1):27-33.
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  202. Brugge JS, Purchio AF, Erikson RL. Virus-specific RNA species present in the cytoplasm of Rous sarcoma virus-infected chicken cells. Virology. 1977 Nov; 83(1):16-26.
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  203. Brugge JS, Erikson RL. Identification of a transformation-specific antigen induced by an avian sarcoma virus. Nature. 1977 Sep 22; 269(5626):346-8.
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  204. Erikson E, Brugge JS, Erikson RL. Phosphorylated and nonphosphorylated forms of avian sarcoma virus polypeptide p19. Virology. 1977 Jul 1; 80(1):177-85.
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  205. Vollet JJ, Brugge JS, Noonan CA, Butel JS. The role of SV40 gene A in the alteration of microfilaments in transformed cells. Exp Cell Res. 1977 Mar 1; 105(1):119-26.
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  206. Noonan CA, Brugge JS, Butel JS. Characterization of simian cells tranformed by temperature-sensitive mutants of simian virus 40. J Virol. 1976 Jun; 18(3):1106-19.
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  207. Brugge JS, Butel JS. Role of simian virus 40 gene A function in maintenance of transformation. J Virol. 1975 Mar; 15(3):619-35.
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  208. Butel JS, Brugge JS, Noonan CA. Transformation of primate and rodent cells by temperature-sensitive mutants of SV40. Cold Spring Harb Symp Quant Biol. 1975; 39 Pt 1:25-36.
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