Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Daniel J. Tschumperlin, Ph.D.

TitleAssociate Professor of Bioengineering and Airway Biology
InstitutionHarvard School of Public Health
DepartmentEH - Molecular+Integrative Phys Sci Prog
AddressHarvard School of Public Health
SPH1-309, Physiology
665 Huntington Ave
Boston MA 02115
Phone617/432-4381
Fax617/432-3468

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Johnson LA, Rodansky ES, Sauder KL, Horowitz JC, Mih JD, Tschumperlin DJ, Higgins PD. Matrix stiffness corresponding to strictured bowel induces a fibrogenic response in human colonic fibroblasts. Inflamm Bowel Dis. 2013 Apr; 19(5):891-903.
    View in: PubMed
  2. Marinkovic A, Liu F, Tschumperlin DJ. Matrices of physiologic stiffness potently inactivate idiopathic pulmonary fibrosis fibroblasts. Am J Respir Cell Mol Biol. 2013 Apr; 48(4):422-30.
    View in: PubMed
  3. Tschumperlin DJ, Liu F, Tager AM. Biomechanical regulation of mesenchymal cell function. Curr Opin Rheumatol. 2013 Jan; 25(1):92-100.
    View in: PubMed
  4. Tschumperlin DJ, Jones JC, Senior RM. The fibrotic matrix in control: does the extracellular matrix drive progression of idiopathic pulmonary fibrosis? Am J Respir Crit Care Med. 2012 Nov 1; 186(9):814-6.
    View in: PubMed
  5. Mih JD, Marinkovic A, Liu F, Sharif AS, Tschumperlin DJ. Matrix stiffness reverses the effect of actomyosin tension on cell proliferation. J Cell Sci. 2012 Dec 15; 125(Pt 24):5974-83.
    View in: PubMed
  6. Patel NR, Bole M, Chen C, Hardin CC, Kho AT, Mih J, Deng L, Butler J, Tschumperlin D, Fredberg JJ, Krishnan R, Koziel H. Cell elasticity determines macrophage function. PLoS One. 2012; 7(9):e41024.
    View in: PubMed
  7. Park JA, Sharif AS, Tschumperlin DJ, Lau L, Limbrey R, Howarth P, Drazen JM. Tissue factor-bearing exosome secretion from human mechanically stimulated bronchial epithelial cells in vitro and in vivo. J Allergy Clin Immunol. 2012 Dec; 130(6):1375-83.
    View in: PubMed
  8. Marinkovic A, Mih JD, Park JA, Liu F, Tschumperlin DJ. Improved throughput traction microscopy reveals pivotal role for matrix stiffness in fibroblast contractility and TGF-ß responsiveness. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 1; 303(3):L169-80.
    View in: PubMed
  9. Tilghman RW, Blais EM, Cowan CR, Sherman NE, Grigera PR, Jeffery ED, Fox JW, Blackman BR, Tschumperlin DJ, Papin JA, Parsons JT. Matrix rigidity regulates cancer cell growth by modulating cellular metabolism and protein synthesis. PLoS One. 2012; 7(5):e37231.
    View in: PubMed
  10. Liu F, Tschumperlin DJ. Micro-mechanical characterization of lung tissue using atomic force microscopy. J Vis Exp. 2011; (54).
    View in: PubMed
  11. Mih JD, Sharif AS, Liu F, Marinkovic A, Symer MM, Tschumperlin DJ. A multiwell platform for studying stiffness-dependent cell biology. PLoS One. 2011; 6(5):e19929.
    View in: PubMed
  12. Tschumperlin DJ. Physical forces and airway remodeling in asthma. N Engl J Med. 2011 May 26; 364(21):2058-9.
    View in: PubMed
  13. Shiomi T, Boudreault F, Padem N, Higashiyama S, Drazen JM, Tschumperlin DJ. Lysophosphatidic acid stimulates epidermal growth factor-family ectodomain shedding and paracrine signaling from human lung fibroblasts. Wound Repair Regen. 2011 Mar-Apr; 19(2):229-40.
    View in: PubMed
  14. Kojic N, Huang A, Chung E, Ivanovic M, Filipovic N, Kojic M, Tschumperlin DJ. A 3-D model of ligand transport in a deforming extracellular space. Biophys J. 2010 Dec 1; 99(11):3517-25.
    View in: PubMed
  15. Shiomi T, Tschumperlin DJ, Park JA, Sunnarborg SW, Horiuchi K, Blobel CP, Drazen JM. TNF-a-converting enzyme/a disintegrin and metalloprotease-17 mediates mechanotransduction in murine tracheal epithelial cells. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):376-85.
    View in: PubMed
  16. Tilghman RW, Cowan CR, Mih JD, Koryakina Y, Gioeli D, Slack-Davis JK, Blackman BR, Tschumperlin DJ, Parsons JT. Matrix rigidity regulates cancer cell growth and cellular phenotype. PLoS One. 2010; 5(9):e12905.
    View in: PubMed
  17. Liu F, Mih JD, Shea BS, Kho AT, Sharif AS, Tager AM, Tschumperlin DJ. Feedback amplification of fibrosis through matrix stiffening and COX-2 suppression. J Cell Biol. 2010 Aug 23; 190(4):693-706.
    View in: PubMed
  18. Park JA, Drazen JM, Tschumperlin DJ. The chitinase-like protein YKL-40 is secreted by airway epithelial cells at base line and in response to compressive mechanical stress. J Biol Chem. 2010 Sep 24; 285(39):29817-25.
    View in: PubMed
  19. Berntsen P, Park CY, Rothen-Rutishauser B, Tsuda A, Sager TM, Molina RM, Donaghey TC, Alencar AM, Kasahara DI, Ericsson T, Millet EJ, Swenson J, Tschumperlin DJ, Butler JP, Brain JD, Fredberg JJ, Gehr P, Zhou EH. Biomechanical effects of environmental and engineered particles on human airway smooth muscle cells. J R Soc Interface. 2010 Jun 6; 7 Suppl 3:S331-40.
    View in: PubMed
  20. Kojic N, Chung E, Kho AT, Park JA, Huang A, So PT, Tschumperlin DJ. An EGFR autocrine loop encodes a slow-reacting but dominant mode of mechanotransduction in a polarized epithelium. FASEB J. 2010 May; 24(5):1604-15.
    View in: PubMed
  21. Tschumperlin DJ, Boudreault F, Liu F. Recent advances and new opportunities in lung mechanobiology. J Biomech. 2010 Jan 5; 43(1):99-107.
    View in: PubMed
  22. Boudreault F, Tschumperlin DJ. Stretch-induced mitogen-activated protein kinase activation in lung fibroblasts is independent of receptor tyrosine kinases. Am J Respir Cell Mol Biol. 2010 Jul; 43(1):64-73.
    View in: PubMed
  23. Park JA, Tschumperlin DJ. Chronic intermittent mechanical stress increases MUC5AC protein expression. Am J Respir Cell Mol Biol. 2009 Oct; 41(4):459-66.
    View in: PubMed
  24. Kojic N, Huang A, Chung E, Tschumperlin D, So PT. Quantification of three-dimensional dynamics of intercellular geometry under mechanical loading using a weighted directional adaptive-threshold method. Opt Express. 2008 Aug 4; 16(16):12403-14.
    View in: PubMed
  25. Trepat X, Deng L, An SS, Navajas D, Tschumperlin DJ, Gerthoffer WT, Butler JP, Fredberg JJ. Universal physical responses to stretch in the living cell. Nature. 2007 May 31; 447(7144):592-5.
    View in: PubMed
  26. Leung LY, Tian D, Brangwynne CP, Weitz DA, Tschumperlin DJ. A new microrheometric approach reveals individual and cooperative roles for TGF-beta1 and IL-1beta in fibroblast-mediated stiffening of collagen gels. FASEB J. 2007 Jul; 21(9):2064-73.
    View in: PubMed
  27. Chu EK, Cheng J, Foley JS, Mecham BH, Owen CA, Haley KJ, Mariani TJ, Kohane IS, Tschumperlin DJ, Drazen JM. Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2006 Dec; 35(6):628-38.
    View in: PubMed
  28. Kojic N, Kojic M, Tschumperlin DJ. Computational modeling of extracellular mechanotransduction. Biophys J. 2006 Jun 1; 90(11):4261-70.
    View in: PubMed
  29. Tschumperlin DJ, Drazen JM. Chronic effects of mechanical force on airways. Annu Rev Physiol. 2006; 68:563-83.
    View in: PubMed
  30. Chu EK, Foley JS, Cheng J, Patel AS, Drazen JM, Tschumperlin DJ. Bronchial epithelial compression regulates epidermal growth factor receptor family ligand expression in an autocrine manner. Am J Respir Cell Mol Biol. 2005 May; 32(5):373-80.
    View in: PubMed
  31. Tschumperlin DJ. EGFR autocrine signaling in a compliant interstitial space: mechanotransduction from the outside in. Cell Cycle. 2004 Aug; 3(8):996-7.
    View in: PubMed
  32. Tschumperlin DJ, Dai G, Maly IV, Kikuchi T, Laiho LH, McVittie AK, Haley KJ, Lilly CM, So PT, Lauffenburger DA, Kamm RD, Drazen JM. Mechanotransduction through growth-factor shedding into the extracellular space. Nature. 2004 May 6; 429(6987):83-6.
    View in: PubMed
  33. Kikuchi T, Shively JD, Foley JS, Drazen JM, Tschumperlin DJ. Differentiation-dependent responsiveness of bronchial epithelial cells to IL-4/13 stimulation. Am J Physiol Lung Cell Mol Physiol. 2004 Jul; 287(1):L119-26.
    View in: PubMed
  34. Tschumperlin DJ, Shively JD, Kikuchi T, Drazen JM. Mechanical stress triggers selective release of fibrotic mediators from bronchial epithelium. Am J Respir Cell Mol Biol. 2003 Feb; 28(2):142-9.
    View in: PubMed
  35. Tschumperlin DJ, Shively JD, Swartz MA, Silverman ES, Haley KJ, Raab G, Drazen JM. Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression. Am J Physiol Lung Cell Mol Physiol. 2002 May; 282(5):L904-11.
    View in: PubMed
  36. Tschumperlin DJ, Drazen JM. Mechanical stimuli to airway remodeling. Am J Respir Crit Care Med. 2001 Nov 15; 164(10 Pt 2):S90-4.
    View in: PubMed
  37. Swartz MA, Tschumperlin DJ, Kamm RD, Drazen JM. Mechanical stress is communicated between different cell types to elicit matrix remodeling. Proc Natl Acad Sci U S A. 2001 May 22; 98(11):6180-5.
    View in: PubMed
  38. Maksym GN, Fabry B, Butler JP, Navajas D, Tschumperlin DJ, Laporte JD, Fredberg JJ. Mechanical properties of cultured human airway smooth muscle cells from 0.05 to 0.4 Hz. J Appl Physiol. 2000 Oct; 89(4):1619-32.
    View in: PubMed
  39. Tschumperlin DJ, Oswari J, Margulies AS. Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitude. Am J Respir Crit Care Med. 2000 Aug; 162(2 Pt 1):357-62.
    View in: PubMed
  40. Tschumperlin DJ, Margulies SS. Alveolar epithelial surface area-volume relationship in isolated rat lungs. J Appl Physiol. 1999 Jun; 86(6):2026-33.
    View in: PubMed
  41. Tschumperlin DJ, Margulies SS. Equibiaxial deformation-induced injury of alveolar epithelial cells in vitro. Am J Physiol. 1998 Dec; 275(6 Pt 1):L1173-83.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: SPH faculty should contact Maria Maxell (mmaxellhsph.harvard.edu).
Tschumperlin's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
See all (223) concept(s)
_
Co-Authors
See all (21) people
_
Similar People
See all (60) people
_
Same Department
Search Department
Physical Neighbors
_