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Laura E. Fredenburgh, M.D.,C.M.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Pulmonary & Critical Care
75 Francis St
Boston MA 02115
Phone617/732-7420
Fax617/726-6878

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Dolinay T, Kim YS, Howrylak J, Hunninghake GM, An CH, Fredenburgh L, Massaro AF, Rogers A, Gazourian L, Nakahira K, Haspel JA, Landazury R, Eppanapally S, Christie JD, Meyer NJ, Ware LB, Christiani DC, Ryter SW, Baron RM, Choi AM. Inflammasome-regulated cytokines are critical mediators of acute lung injury. Am J Respir Crit Care Med. 2012 Jun 1; 185(11):1225-34.
    View in: PubMed
  2. Tropea KA, Leder E, Aslam M, Lau AN, Raiser DM, Lee JH, Balasubramaniam V, Fredenburgh LE, Alex Mitsialis S, Kourembanas S, Kim CF. Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2012 May 1; 302(9):L829-37.
    View in: PubMed
  3. Fredenburgh LE, Velandia MM, Ma J, Olszak T, Cernadas M, Englert JA, Chung SW, Liu X, Begay C, Padera RF, Blumberg RS, Walsh SR, Baron RM, Perrella MA. Cyclooxygenase-2 deficiency leads to intestinal barrier dysfunction and increased mortality during polymicrobial sepsis. J Immunol. 2011 Nov 15; 187(10):5255-67.
    View in: PubMed
  4. Fredenburgh LE, Ma J, Perrella MA. Cyclooxygenase-2 inhibition and hypoxia-induced pulmonary hypertension: effects on pulmonary vascular remodeling and contractility. Trends Cardiovasc Med. 2009 Feb; 19(2):31-7.
    View in: PubMed
  5. Takamiya R, Hung CC, Hall SR, Fukunaga K, Nagaishi T, Maeno T, Owen C, Macias AA, Fredenburgh LE, Ishizaka A, Blumberg RS, Baron RM, Perrella MA. High-mobility group box 1 contributes to lethality of endotoxemia in heme oxygenase-1-deficient mice. Am J Respir Cell Mol Biol. 2009 Aug; 41(2):129-35.
    View in: PubMed
  6. Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA. Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation. 2008 Apr 22; 117(16):2114-22.
    View in: PubMed
  7. Fredenburgh LE, Campion EW, Drazen JM. Clinical Decisions. Mild persistent asthma--polling results. N Engl J Med. 2007 Jul 12; 357(2):179-80.
    View in: PubMed
  8. Fredenburgh LE, Perrella MA, Mitsialis SA. The role of heme oxygenase-1 in pulmonary disease. Am J Respir Cell Mol Biol. 2007 Feb; 36(2):158-65.
    View in: PubMed
  9. Fredenburgh LE, Liang OD, Macias, AA, Mitsialis SA, Kourembanas S, Perrella MA. Exacerbation of Hypoxia-Induced Pulmonary Hypertension and Vascular Remodeling in COX-2 deficient mice. Proc Am Thorac Soc. 2006; 3:A278.
  10. Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA. Absence of Heme Oxygenase-1 Expression in the Lung Parenchyma Exacerbates Endotoxin-Induced Acute Lung Injury. Proc Am Thorac Soc. 2006; 3:A571.
  11. Fredenburgh LE, Baron RM, Carvajal IM, Mouded M, Macias AA, Ith B, Perrella MA. Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels. Cell Mol Biol (Noisy-le-grand). 2005 Oct 3; 51(5):513-20.
    View in: PubMed
  12. Fukunaga K, Kohli P, Bonnans C, Fredenburgh LE, Levy BD. Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. J Immunol. 2005 Apr 15; 174(8):5033-9.
    View in: PubMed
  13. Baron RM, Fredenburgh LE, Macias AA, Okabe RO, Layne MD, Perrella MA. Reduction of Nitric Oxide Synthase 2 Expression by Minor Groove Binding Agents Improves Survival from Endotoxemia. Proc Am Thorac Soc. 2005; 2:A.
  14. Fredenburgh LE, Ejima K, Baron RM, Chung SW, Layne MD, Perrella MA. Enhanced COX-2 Expression in HO-1 Null Mice Contributes to Endotoxemic Lung Injury. Proc Am Thorac Soc. 2005; 2: A152. 2005; 2:A152.
  15. Baron RM, Carvajal IM, Liu X, Okabe RO, Fredenburgh LE, Macias AA, Chen YH, Ejima K, Layne MD, Perrella MA. Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia. J Immunol. 2004 Sep 15; 173(6):4147-53.
    View in: PubMed
  16. Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Cullivan ML, Haley KJ, Sonna LA, De Sanctis GT, Ingenito EP, Perrella MA. Nitric oxide synthase-2 down-regulates surfactant protein-B expression and enhances endotoxin-induced lung injury in mice. FASEB J. 2004 Aug; 18(11):1276-8.
    View in: PubMed
  17. Fredenburgh LE, Ejima K, Liu X, Baron RM, and Perrella MA. Attenuation of Hypotension in COX-2 Null Mice Contributes to Improved Outcome In Endotoxemia. Am J Resp Crit Care Med. 2004; 169(7):A636.
  18. Baron RM, Carvajal IM, Fredenburgh LE, Liu X, Porrata Y, Haley KJ, Sonna LA, DeSanctis GT, Ingenito EP, Perrella MA. Nitric Oxide Synthase-2 Mediates Acute Lung Injury in Mice through Decreased Surfactant Protein-B Expression. Am J Resp Crit Care Med. 2004; 169(7):A264.
  19. Chung SW, Chen Y-H, Fredenburgh LE, Layne MD, Yet S-F, Perrella MA. Ets2 Enhances Heme Oxygenase-1 Gene Expression through an Akt-independent Phosphoinositide 3 (PI3)-Kinase Pathway. Am J Resp Crit Care Med. 2004; 169(7169):A423.
  20. Baron RM, Carvajal IM, Fredenburgh LE, Porrata Y, Haley K, Sonna LA, Layne MD, Yet S-F, Ingenito EP, Perrella MA . Nitric Oxide Synthase 2 Mediates Acute Lung Injury in Mice Through Decreased Surfactant Protein B Expression. Circulation. 2003; 108:269.
  21. Mallory FB, Mallory CW, Butler KE, Lewis MB, Xia AQ, Luzik ED, Fredenburgh LE, Ramanjulu MM, Van QN, Francl MM, Freed DA, Wray CC, Hann C, Nerz-Stormes M, Carroll PJ, Chirlian LE. Nuclear Spin-Spin Coupling via Nonbonded Interactions. 8. The Distance Dependence of Through-Space Fluorine-Fluorine Coupling. Journal of the American Chemical Society. 2000; 122:4108-4116.
  22. Fredenburgh LE, Dougherty G . Potential Impact of Once-A-Day Ceftriaxone on Reducing Inappropriate Hospitalization for Pediatric Cellulitis. Archives of Pediatrics and Adolescent Medicine. 1996; 150(Supp):76.
  23. Senanayake CH, Smith GB, Ryan KM, Fredenburgh LE, Liu J, Roberts FE, Hughes DL, Larsen RD, Verhoeven TR, Reider PJ. . . 1996; 37: 3271-3274. The Role of 4-(3-Phenylpropyl)pyridine N-oxide (P3NO) in the Manganese-Salen-Catalyzed Asymmetric Epoxidation of Indene. Tetrahedron Letters. 1996; 37:3271-3274.
  24. Senanayake CH, Fredenburgh LE, Reamer RA, Liu J, Roberts FE, Humphrey G, Thompson AS, Larsen RD, Verhoeven TR, Reider PJ, Shinkai I. New Approach to the Imidazolutidine Moiety of MK-996. Heterocycles. 1996; 42:821-830.
  25. Fredenburgh LE, Larsen RD, Liu J, Reamer RA, Senanayake CH, Verhoeven TR. Process for the Preparation of Imidazolutidine. 1995.
  26. Senanayake CH, DiMichele LM, Liu J, Fredenburgh LE, Ryan KM, Roberts FE, Larsen RD, Verhoeven TR, Reider PJ. Regio- and Stereocontrolled Syntheses of Cyclic Chiral cis-Amino Alcohols from 1,2-Diols or Epoxides. Tetrahedron Letters. 1995; 36:7615-7618.
  27. Senanayake CH, Roberts FE, DiMichele LM, Ryan KM, Liu J, Fredenburgh LE, Foster BS, Douglas AW, Larsen RD, Verhoeven TR, Reider PJ. The Behavior of Indene Oxide in the Ritter Reaction: A Simple Route to cis-Aminoindanol. Tetrahedron Letters. 1995; 36:3993-3996.
  28. Senanayake CH, Fredenburgh LE, Reamer RA, Larsen RD, Verhoeven TR, Reider PJ. Nature of N-Bromosuccinimide in Basic Media: The True Oxidizing Species in the Hofmann Rearrangement. Journal of the American Chemical Society. 1994; 116:7947-7948.
  29. Senanayake CH, Fredenburgh LE, Reamer RA, Liu J, Larsen RD, Verhoeven TR, Reider PJ. Magnesium-Assisted Imidazole Formation from Unreactive Ureas. Tetrahedron Letters. 1994; 35:5775-5778.
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