 Clint L. Makino, PH.D.
| Title | Associate Professor of Ophthalmology (Neuroscience) |
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| Institution | Massachusetts Eye and Ear Infirmary |
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| Department | Ophthalmology |
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| Address | Massachusetts Eye & Ear Infrm
Ophthalmology
243 Charles St
Boston MA 02114
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| Phone | 617/573-4462 |
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| Fax | 617/573-4290 |
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 Mentoring Available: 11/01/12, Expires: 11/01/13 Student will use microspectrophotometry to monitor the vitamin A content in single rod photoreceptors in the presence and absence of metabolic inhibitors to test for active extrusion. Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Makino CL, Wen XH, Olshevskaya EV, Peshenko IV, Savchenko AB, Dizhoor AM. Enzymatic Relay Mechanism Stimulates Cyclic GMP Synthesis in Rod Photoresponse: Biochemical and Physiological Study in Guanylyl Cyclase Activating Protein 1 Knockout Mice. PLoS One. 2012; 7(10):e47637.
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Makino CL. Easy does it when bleaching isolated mouse rods. J Physiol. 2012 Jun 1; 590(Pt 11):2551-2.
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Makino CL, Wen XH, Michaud NA, Covington HI, DiBenedetto E, Hamm HE, Lem J, Caruso G. Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics. PLoS One. 2012; 7(5):e37832.
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Wen XH, Duda T, Pertzev A, Venkataraman V, Makino CL, Sharma RK. S100B serves as a Ca(2+) sensor for ROS-GC1 guanylate cyclase in cones but not in rods of the murine retina. Cell Physiol Biochem. 2012; 29(3-4):417-30.
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Miyazono S, Isayama T, Delori FC, Makino CL. Vitamin A activates rhodopsin and sensitizes it to ultraviolet light. Vis Neurosci. 2011 Nov; 28(6):485-97.
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Makino CL, Riley CK, Looney J, Crouch RK, Okada T. Binding of more than one retinoid to visual opsins. Biophys J. 2010 Oct 6; 99(7):2366-73.
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Liu X, Pawlyk BS, Adamian M, Olshevskaya EV, Dizhoor AM, Makino CL, Li T. Increased light exposure alleviates one form of photoreceptor degeneration marked by elevated calcium in the dark. PLoS One. 2009; 4(12):e8438.
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Isayama T, McCabe England SL, Crouch RK, Zimmerman AL, Makino CL. Beta-ionone activates and bleaches visual pigment in salamander photoreceptors. Vis Neurosci. 2009 May-Jun; 26(3):267-74.
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Wen XH, Shen L, Brush RS, Michaud N, Al-Ubaidi MR, Gurevich VV, Hamm HE, Lem J, Dibenedetto E, Anderson RE, Makino CL. Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophys J. 2009 Feb; 96(3):939-50.
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Makino CL, Peshenko IV, Wen XH, Olshevskaya EV, Barrett R, Dizhoor AM. A role for GCAP2 in regulating the photoresponse. Guanylyl cyclase activation and rod electrophysiology in GUCA1B knock-out mice. J Biol Chem. 2008 Oct 24; 283(43):29135-43.
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Yang J, Pawlyk B, Wen XH, Adamian M, Soloviev M, Michaud N, Zhao Y, Sandberg MA, Makino CL, Li T. Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals. Hum Mol Genet. 2007 May 1; 16(9):1017-29.
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Isayama T, Chen Y, Kono M, Degrip WJ, Ma JX, Crouch RK, Makino CL. Differences in the pharmacological activation of visual opsins. Vis Neurosci. 2006 Nov-Dec; 23(6):899-908.
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Isayama T, Alexeev D, Makino CL, Washington I, Nakanishi K, Turro NJ. An accessory chromophore in red vision. Nature. 2006 Oct 12; 443(7112):649.
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He Q, Alexeev D, Estevez ME, McCabe SL, Calvert PD, Ong DE, Cornwall MC, Zimmerman AL, Makino CL. Cyclic nucleotide-gated ion channels in rod photoreceptors are protected from retinoid inhibition. J Gen Physiol. 2006 Oct; 128(4):473-85.
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Makino CL, Wen XH, Michaud N, Peshenko IV, Pawlyk B, Brush RS, Soloviev M, Liu X, Woodruff ML, Calvert PD, Savchenko AB, Anderson RE, Fain GL, Li T, Sandberg MA, Dizhoor AM. Effects of low AIPL1 expression on phototransduction in rods. Invest Ophthalmol Vis Sci. 2006 May; 47(5):2185-94.
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Yang J, Gao J, Adamian M, Wen XH, Pawlyk B, Zhang L, Sanderson MJ, Zuo J, Makino CL, Li T. The ciliary rootlet maintains long-term stability of sensory cilia. Mol Cell Biol. 2005 May; 25(10):4129-37.
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Wang Z, Wen XH, Ablonczy Z, Crouch RK, Makino CL, Lem J. Enhanced shutoff of phototransduction in transgenic mice expressing palmitoylation-deficient rhodopsin. J Biol Chem. 2005 Jul 1; 280(26):24293-300.
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Liu X, Bulgakov OV, Wen XH, Woodruff ML, Pawlyk B, Yang J, Fain GL, Sandberg MA, Makino CL, Li T. AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase. Proc Natl Acad Sci U S A. 2004 Sep 21; 101(38):13903-8.
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Olshevskaya EV, Calvert PD, Woodruff ML, Peshenko IV, Savchenko AB, Makino CL, Ho YS, Fain GL, Dizhoor AM. The Y99C mutation in guanylyl cyclase-activating protein 1 increases intracellular Ca2+ and causes photoreceptor degeneration in transgenic mice. J Neurosci. 2004 Jul 7; 24(27):6078-85.
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Makino CL, Dodd RL, Chen J, Burns ME, Roca A, Simon MI, Baylor DA. Recoverin regulates light-dependent phosphodiesterase activity in retinal rods. J Gen Physiol. 2004 Jun; 123(6):729-41.
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Makino CL, Wen XH, Lem J. Piecing together the timetable for visual transduction with transgenic animals. Curr Opin Neurobiol. 2003 Aug; 13(4):404-12.
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Calvert PD, Govardovskii VI, Arshavsky VY, Makino CL. Two temporal phases of light adaptation in retinal rods. J Gen Physiol. 2002 Feb; 119(2):129-45.
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Calvert PD, Makino CL. The time course of light adaptation in vertebrate retinal rods. Adv Exp Med Biol. 2002; 514:37-60.
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Ma J, Znoiko S, Othersen KL, Ryan JC, Das J, Isayama T, Kono M, Oprian DD, Corson DW, Cornwall MC, Cameron DA, Harosi FI, Makino CL, Crouch RK. A visual pigment expressed in both rod and cone photoreceptors. Neuron. 2001 Nov 8; 32(3):451-61.
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Sieving PA, Fowler ML, Bush RA, Machida S, Calvert PD, Green DG, Makino CL, McHenry CL. Constitutive "light" adaptation in rods from G90D rhodopsin: a mechanism for human congenital nightblindness without rod cell loss. J Neurosci. 2001 Aug 1; 21(15):5449-60.
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Calvert PD, Govardovskii VI, Krasnoperova N, Anderson RE, Lem J, Makino CL. Membrane protein diffusion sets the speed of rod phototransduction. Nature. 2001 May 3; 411(6833):90-4.
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Calvert PD, Krasnoperova NV, Lyubarsky AL, Isayama T, Nicoló M, Kosaras B, Wong G, Gannon KS, Margolskee RF, Sidman RL, Pugh EN, Makino CL, Lem J. Phototransduction in transgenic mice after targeted deletion of the rod transducin alpha -subunit. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13913-8.
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Makino CL, Groesbeek M, Lugtenburg J, Baylor DA. Spectral tuning in salamander visual pigments studied with dihydroretinal chromophores. Biophys J. 1999 Aug; 77(2):1024-35.
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Lem J, Krasnoperova NV, Calvert PD, Kosaras B, Cameron DA, Nicolò M, Makino CL, Sidman RL. Morphological, physiological, and biochemical changes in rhodopsin knockout mice. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):736-41.
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Xu J, Dodd RL, Makino CL, Simon MI, Baylor DA, Chen J. Prolonged photoresponses in transgenic mouse rods lacking arrestin. Nature. 1997 Oct 2; 389(6650):505-9.
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Lem J, Makino CL. Phototransduction in transgenic mice. Curr Opin Neurobiol. 1996 Aug; 6(4):453-8.
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Makino CL, Dodd RL. Multiple visual pigments in a photoreceptor of the salamander retina. J Gen Physiol. 1996 Jul; 108(1):27-34.
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Chen J, Makino CL, Peachey NS, Baylor DA, Simon MI. Mechanisms of rhodopsin inactivation in vivo as revealed by a COOH-terminal truncation mutant. Science. 1995 Jan 20; 267(5196):374-7.
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Sung CH, Makino C, Baylor D, Nathans J. A rhodopsin gene mutation responsible for autosomal dominant retinitis pigmentosa results in a protein that is defective in localization to the photoreceptor outer segment. J Neurosci. 1994 Oct; 14(10):5818-33.
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Raport CJ, Lem J, Makino C, Chen CK, Fitch CL, Hobson A, Baylor D, Simon MI, Hurley JB. Downregulation of cGMP phosphodiesterase induced by expression of GTPase-deficient cone transducin in mouse rod photoreceptors. Invest Ophthalmol Vis Sci. 1994 Jun; 35(7):2932-47.
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Makino CL, Taylor WR, Baylor DA. Rapid charge movements and photosensitivity of visual pigments in salamander rods and cones. J Physiol. 1991 Oct; 442:761-80.
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Makino CL, Howard LN, Williams TP. Axial gradients of rhodopsin in light-exposed retinal rods of the toad. J Gen Physiol. 1990 Dec; 96(6):1199-220.
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Makino CL, Kraft TW, Mathies RA, Lugtenburg J, Miley ME, van der Steen R, Baylor DA. Effects of modified chromophores on the spectral sensitivity of salamander, squirrel and macaque cones. J Physiol. 1990 May; 424:545-60.
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Kraft TW, Makino CL, Mathies RA, Lugtenburg J, Schnapf JL, Baylor DA. Cone excitations and color vision. Cold Spring Harb Symp Quant Biol. 1990; 55:635-41.
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Makino CL, Howard LN, Williams TP. Intracellular topography of rhodopsin bleaching. Science. 1987 Dec 18; 238(4834):1716-7.
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