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Last Name
Institution

Peter Karl Sorger, Ph.D.

TitleOtto Krayer Professor of Systems Pharmacology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Systems Biology, Warren Alpert Bld. 438
200 Longwood Ave
Boston MA 02115
Phone617/432-6901
Fax617/432-5012
Other Positions
TitleHead of the Program in Therapeutic Science
InstitutionHarvard Medical School
DepartmentSystems Biology


 Biography 
 awards and honors
1984 - A.B. Summa Cum Laude, Hoopes Prizes for Undergraduate Thesis
1988 - Ph.D. in Biochemistry
2003 - Director, Cell Decision Processes Center

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Koch Y, Wolf T, Sorger PK, Eils R, Brors B. Decision-tree based model analysis for efficient identification of parameter relations leading to different signaling States. PLoS One. 2013; 8(12):e82593.
    View in: PubMed
  2. Sarosiek KA, Chi X, Bachman JA, Sims JJ, Montero J, Patel L, Flanagan A, Andrews DW, Sorger P, Letai A. BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response. Mol Cell. 2013 Sep 26; 51(6):751-65.
    View in: PubMed
  3. Niepel M, Hafner M, Pace EA, Chung M, Chai DH, Zhou L, Schoeberl B, Sorger PK. Profiles of Basal and stimulated receptor signaling networks predict drug response in breast cancer lines. Sci Signal. 2013; 6(294):ra84.
    View in: PubMed
  4. Fallahi-Sichani M, Honarnejad S, Heiser LM, Gray JW, Sorger PK. Metrics other than potency reveal systematic variation in responses to cancer drugs. Nat Chem Biol. 2013 Nov; 9(11):708-14.
    View in: PubMed
  5. Marco E, Dorn JF, Hsu PH, Jaqaman K, Sorger PK, Danuser G. S. cerevisiae Chromosomes Biorient via Gradual Resolution of Syntely between S Phase and Anaphase. Cell. 2013 Aug 29; 154(5):1127-39.
    View in: PubMed
  6. Paull EO, Carlin DE, Niepel M, Sorger PK, Haussler D, Stuart JM. Discovering causal pathways linking genomic events to transcriptional states using Tied Diffusion Through Interacting Events (TieDIE). Bioinformatics. 2013 Nov 1; 29(21):2757-64.
    View in: PubMed
  7. Flusberg DA, Sorger PK. Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging. Phys Biol. 2013 Jun; 10(3):035002.
    View in: PubMed
  8. Flusberg DA, Roux J, Spencer SL, Sorger PK. Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes. Mol Biol Cell. 2013 Jul; 24(14):2186-200.
    View in: PubMed
  9. McAllister FE, Niepel M, Haas W, Huttlin E, Sorger PK, Gygi SP. Mass spectrometry based method to increase throughput for kinome analyses using ATP probes. Anal Chem. 2013 May 7; 85(9):4666-74.
    View in: PubMed
  10. Lopez CF, Muhlich JL, Bachman JA, Sorger PK. Programming biological models in Python using PySB. Mol Syst Biol. 2013 Feb 19; 9:646.
    View in: PubMed
  11. Eydgahi H, Chen WW, Muhlich JL, Vitkup D, Tsitsiklis JN, Sorger PK. Properties of cell death models calibrated and compared using Bayesian approaches. Mol Syst Biol. 2013 Feb 5; 9:644.
    View in: PubMed
  12. Foijer F, Ditommaso T, Donati G, Hautaviita K, Xie SZ, Heath E, Smyth I, Watt FM, Sorger PK, Bradley A. Spindle checkpoint deficiency is tolerated by murine epidermal cells but not hair follicle stem cells. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2928-33.
    View in: PubMed
  13. Koytiger G, Kaushansky A, Gordus A, Rush J, Sorger PK, Macbeath G. Phosphotyrosine Signaling Proteins that Drive Oncogenesis Tend to be Highly Interconnected. Mol Cell Proteomics. 2013 May; 12(5):1204-13.
    View in: PubMed
  14. Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R. Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun. 2013; 4:1504.
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  15. Sorger PK, Schoeberl B. An expanding role for cell biologists in drug discovery and pharmacology. Mol Biol Cell. 2012 Nov; 23(21):4162-4.
    View in: PubMed
  16. Gujral TS, Karp RL, Finski A, Chan M, Schwartz PE, Macbeath G, Sorger P. Profiling phospho-signaling networks in breast cancer using reverse-phase protein arrays. Oncogene. 2013 Jul 18; 32(29):3470-6.
    View in: PubMed
  17. Bagci-Onder T, Agarwal A, Flusberg D, Wanningen S, Sorger P, Shah K. Real-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors. Oncogene. 2013 Jun 6; 32(23):2818-27.
    View in: PubMed
  18. Lee MJ, Ye AS, Gardino AK, Heijink AM, Sorger PK, MacBeath G, Yaffe MB. Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell. 2012 May 11; 149(4):780-94.
    View in: PubMed
  19. Kirouac DC, Saez-Rodriguez J, Swantek J, Burke JM, Lauffenburger DA, Sorger PK. Creating and analyzing pathway and protein interaction compendia for modelling signal transduction networks. BMC Syst Biol. 2012; 6:29.
    View in: PubMed
  20. Gaudet S, Spencer SL, Chen WW, Sorger PK. Exploring the contextual sensitivity of factors that determine cell-to-cell variability in receptor-mediated apoptosis. PLoS Comput Biol. 2012; 8(4):e1002482.
    View in: PubMed
  21. Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, Sorger PK, Alessi DR, Gray NS. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27; 19(1):140-54.
    View in: PubMed
  22. Luckert K, Gujral TS, Chan M, Sevecka M, Joos TO, Sorger PK, Macbeath G, Pötz O. A dual array-based approach to assess the abundance and posttranslational modification state of signaling proteins. Sci Signal. 2012 Jan 10; 5(206):pl1.
    View in: PubMed
  23. Liu Q, Kirubakaran S, Hur W, Niepel M, Westover K, Thoreen CC, Wang J, Ni J, Patricelli MP, Vogel K, Riddle S, Waller DL, Traynor R, Sanda T, Zhao Z, Kang SA, Zhao J, Look AT, Sorger PK, Sabatini DM, Gray NS. Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics. J Biol Chem. 2012 Mar 23; 287(13):9742-52.
    View in: PubMed
  24. Aldridge BB, Gaudet S, Lauffenburger DA, Sorger PK. Lyapunov exponents and phase diagrams reveal multi-factorial control over TRAIL-induced apoptosis. Mol Syst Biol. 2011; 7:553.
    View in: PubMed
  25. Hagan RS, Manak MS, Buch HK, Meier MG, Meraldi P, Shah JV, Sorger PK. p31(comet) acts to ensure timely spindle checkpoint silencing subsequent to kinetochore attachment. Mol Biol Cell. 2011 Nov; 22(22):4236-46.
    View in: PubMed
  26. Kleiman LB, Maiwald T, Conzelmann H, Lauffenburger DA, Sorger PK. Rapid phospho-turnover by receptor tyrosine kinases impacts downstream signaling and drug binding. Mol Cell. 2011 Sep 2; 43(5):723-37.
    View in: PubMed
  27. Rines DR, Thomann D, Dorn JF, Goodwin P, Sorger PK. Live cell imaging of yeast. Cold Spring Harb Protoc. 2011 Sep; 2011(9).
    View in: PubMed
  28. Prill RJ, Saez-Rodriguez J, Alexopoulos LG, Sorger PK, Stolovitzky G. Crowdsourcing network inference: the DREAM predictive signaling network challenge. Sci Signal. 2011 Sep 6; 4(189):mr7.
    View in: PubMed
  29. Saez-Rodriguez J, Alexopoulos LG, Zhang M, Morris MK, Lauffenburger DA, Sorger PK. Comparing signaling networks between normal and transformed hepatocytes using discrete logical models. Cancer Res. 2011 Aug 15; 71(16):5400-11.
    View in: PubMed
  30. Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ. Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res. 2011 Jul 1; 71(13):4608-16.
    View in: PubMed
  31. Hached K, Xie SZ, Buffin E, Cladière D, Rachez C, Sacras M, Sorger PK, Wassmann K. Mps1 at kinetochores is essential for female mouse meiosis I. Development. 2011 Jun; 138(11):2261-71.
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  32. Millard BL, Niepel M, Menden MP, Muhlich JL, Sorger PK. Adaptive informatics for multifactorial and high-content biological data. Nat Methods. 2011 Jun; 8(6):487-93.
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  33. Cho US, Corbett KD, Al-Bassam J, Bellizzi JJ, De Wulf P, Espelin CW, Miranda JJ, Simons K, Wei RR, Sorger PK, Harrison SC. Molecular structures and interactions in the yeast kinetochore. Cold Spring Harb Symp Quant Biol. 2010; 75:395-401.
    View in: PubMed
  34. Spencer SL, Sorger PK. Measuring and modeling apoptosis in single cells. Cell. 2011 Mar 18; 144(6):926-39.
    View in: PubMed
  35. Luckert K, Götschel F, Sorger PK, Hecht A, Joos TO, Pötz O. Snapshots of protein dynamics and post-translational modifications in one experiment--beta-catenin and its functions. Mol Cell Proteomics. 2011 May; 10(5):M110.007377.
    View in: PubMed
  36. Morris MK, Saez-Rodriguez J, Clarke DC, Sorger PK, Lauffenburger DA. Training signaling pathway maps to biochemical data with constrained fuzzy logic: quantitative analysis of liver cell responses to inflammatory stimuli. PLoS Comput Biol. 2011 Mar; 7(3):e1001099.
    View in: PubMed
  37. Bachman JA, Sorger P. New approaches to modeling complex biochemistry. Nat Methods. 2011 Feb; 8(2):130-1.
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  38. Chen WW, Niepel M, Sorger PK. Classic and contemporary approaches to modeling biochemical reactions. Genes Dev. 2010 Sep 1; 24(17):1861-75.
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  39. Espelin CW, Goldsipe A, Sorger PK, Lauffenburger DA, de Graaf D, Hendriks BS. Elevated GM-CSF and IL-1beta levels compromise the ability of p38 MAPK inhibitors to modulate TNFalpha levels in the human monocytic/macrophage U937 cell line. Mol Biosyst. 2010 Oct; 6(10):1956-72.
    View in: PubMed
  40. Yang R, Niepel M, Mitchison TK, Sorger PK. Dissecting variability in responses to cancer chemotherapy through systems pharmacology. Clin Pharmacol Ther. 2010 Jul; 88(1):34-8.
    View in: PubMed
  41. Alexopoulos LG, Saez-Rodriguez J, Cosgrove BD, Lauffenburger DA, Sorger PK. Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes. Mol Cell Proteomics. 2010 Sep; 9(9):1849-65.
    View in: PubMed
  42. Kim KA, Spencer SL, Albeck JG, Burke JM, Sorger PK, Gaudet S, Kim do H. Systematic calibration of a cell signaling network model. BMC Bioinformatics. 2010; 11:202.
    View in: PubMed
  43. Morris MK, Saez-Rodriguez J, Sorger PK, Lauffenburger DA. Logic-based models for the analysis of cell signaling networks. Biochemistry. 2010 Apr 20; 49(15):3216-24.
    View in: PubMed
  44. Lazzara MJ, Lane K, Chan R, Jasper PJ, Yaffe MB, Sorger PK, Jacks T, Neel BG, Lauffenburger DA. Impaired SHP2-mediated extracellular signal-regulated kinase activation contributes to gefitinib sensitivity of lung cancer cells with epidermal growth factor receptor-activating mutations. Cancer Res. 2010 May 1; 70(9):3843-50.
    View in: PubMed
  45. Cosgrove BD, Alexopoulos LG, Hang TC, Hendriks BS, Sorger PK, Griffith LG, Lauffenburger DA. Cytokine-associated drug toxicity in human hepatocytes is associated with signaling network dysregulation. Mol Biosyst. 2010 Jul; 6(7):1195-206.
    View in: PubMed
  46. Prill RJ, Marbach D, Saez-Rodriguez J, Sorger PK, Alexopoulos LG, Xue X, Clarke ND, Altan-Bonnet G, Stolovitzky G. Towards a rigorous assessment of systems biology models: the DREAM3 challenges. PLoS One. 2010; 5(2):e9202.
    View in: PubMed
  47. Saez-Rodriguez J, Alexopoulos LG, Epperlein J, Samaga R, Lauffenburger DA, Klamt S, Sorger PK. Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction. Mol Syst Biol. 2009; 5:331.
    View in: PubMed
  48. Pagliuca C, Draviam VM, Marco E, Sorger PK, De Wulf P. Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint. PLoS One. 2009; 4(10):e7640.
    View in: PubMed
  49. Niepel M, Spencer SL, Sorger PK. Non-genetic cell-to-cell variability and the consequences for pharmacology. Curr Opin Chem Biol. 2009 Dec; 13(5-6):556-61.
    View in: PubMed
  50. Samaga R, Saez-Rodriguez J, Alexopoulos LG, Sorger PK, Klamt S. The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data. PLoS Comput Biol. 2009 Aug; 5(8):e1000438.
    View in: PubMed
  51. Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK. Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature. 2009 May 21; 459(7245):428-32.
    View in: PubMed
  52. Cosgrove BD, King BM, Hasan MA, Alexopoulos LG, Farazi PA, Hendriks BS, Griffith LG, Sorger PK, Tidor B, Xu JJ, Lauffenburger DA. Synergistic drug-cytokine induction of hepatocellular death as an in vitro approach for the study of inflammation-associated idiosyncratic drug hepatotoxicity. Toxicol Appl Pharmacol. 2009 Jun 15; 237(3):317-30.
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  53. Aldridge BB, Saez-Rodriguez J, Muhlich JL, Sorger PK, Lauffenburger DA. Fuzzy logic analysis of kinase pathway crosstalk in TNF/EGF/insulin-induced signaling. PLoS Comput Biol. 2009 Apr; 5(4):e1000340.
    View in: PubMed
  54. Chen WW, Schoeberl B, Jasper PJ, Niepel M, Nielsen UB, Lauffenburger DA, Sorger PK. Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data. Mol Syst Biol. 2009; 5:239.
    View in: PubMed
  55. Aebersold R, Auffray C, Baney E, Barillot E, Brazma A, Brett C, Brunak S, Butte A, Califano A, Celis J, Cufer T, Ferrell J, Galas D, Gallahan D, Gatenby R, Goldbeter A, Hace N, Henney A, Hood L, Iyengar R, Jackson V, Kallioniemi O, Klingmüller U, Kolar P, Kolch W, Kyriakopoulou C, Laplace F, Lehrach H, Marcus F, Matrisian L, Nolan G, Pelkmans L, Potti A, Sander C, Seljak M, Singer D, Sorger P, Stunnenberg H, Superti-Furga G, Uhlen M, Vidal M, Weinstein J, Wigle D, Williams M, Wolkenhauer O, Zhivotovsky B, Zinovyev A, Zupan B. Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008). Mol Oncol. 2009 Feb; 3(1):9-17.
    View in: PubMed
  56. Albeck JG, Burke JM, Spencer SL, Lauffenburger DA, Sorger PK. Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol. 2008 Dec 2; 6(12):2831-52.
    View in: PubMed
  57. Sorger PK. Microfluidics closes in on point-of-care assays. Nat Biotechnol. 2008 Dec; 26(12):1345-6.
    View in: PubMed
  58. Cohen RL, Espelin CW, De Wulf P, Sorger PK, Harrison SC, Simons KT. Structural and functional dissection of Mif2p, a conserved DNA-binding kinetochore protein. Mol Biol Cell. 2008 Oct; 19(10):4480-91.
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  59. Foijer F, Draviam VM, Sorger PK. Studying chromosome instability in the mouse. Biochim Biophys Acta. 2008 Sep; 1786(1):73-82.
    View in: PubMed
  60. Albeck JG, Burke JM, Aldridge BB, Zhang M, Lauffenburger DA, Sorger PK. Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell. 2008 Apr 11; 30(1):11-25.
    View in: PubMed
  61. Saez-Rodriguez J, Goldsipe A, Muhlich J, Alexopoulos LG, Millard B, Lauffenburger DA, Sorger PK. Flexible informatics for linking experimental data to mathematical models via DataRail. Bioinformatics. 2008 Mar 15; 24(6):840-7.
    View in: PubMed
  62. Niault T, Hached K, Sotillo R, Sorger PK, Maro B, Benezra R, Wassmann K. Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I. PLoS One. 2007; 2(11):e1165.
    View in: PubMed
  63. Bellizzi JJ, Sorger PK, Harrison SC. Crystal structure of the yeast inner kinetochore subunit Cep3p. Structure. 2007 Nov; 15(11):1422-30.
    View in: PubMed
  64. Foijer F, Simonis M, van Vliet M, Wessels L, Kerkhoven R, Sorger PK, Te Riele H. Oncogenic pathways impinging on the G2-restriction point. Oncogene. 2008 Feb 14; 27(8):1142-54.
    View in: PubMed
  65. Jaqaman K, Dorn JF, Marco E, Sorger PK, Danuser G. Phenotypic clustering of yeast mutants based on kinetochore microtubule dynamics. Bioinformatics. 2007 Jul 1; 23(13):1666-73.
    View in: PubMed
  66. Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature. 2007 Apr 19; 446(7138):876-81.
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  67. Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ. A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. Nat Cell Biol. 2007 May; 9(5):556-64.
    View in: PubMed
  68. Aldridge BB, Haller G, Sorger PK, Lauffenburger DA. Direct Lyapunov exponent analysis enables parametric study of transient signalling governing cell behaviour. Syst Biol (Stevenage). 2006 Nov; 153(6):425-32.
    View in: PubMed
  69. Albeck JG, MacBeath G, White FM, Sorger PK, Lauffenburger DA, Gaudet S. Collecting and organizing systematic sets of protein data. Nat Rev Mol Cell Biol. 2006 Nov; 7(11):803-12.
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  70. Aldridge BB, Burke JM, Lauffenburger DA, Sorger PK. Physicochemical modelling of cell signalling pathways. Nat Cell Biol. 2006 Nov; 8(11):1195-203.
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  71. Jaqaman K, Dorn JF, Jelson GS, Tytell JD, Sorger PK, Danuser G. Comparative autoregressive moving average analysis of kinetochore microtubule dynamics in yeast. Biophys J. 2006 Sep 15; 91(6):2312-25.
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  72. Fitzgerald JB, Schoeberl B, Nielsen UB, Sorger PK. Systems biology and combination therapy in the quest for clinical efficacy. Nat Chem Biol. 2006 Sep; 2(9):458-66.
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  73. McAinsh AD, Meraldi P, Draviam VM, Toso A, Sorger PK. The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation. EMBO J. 2006 Sep 6; 25(17):4033-49.
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  74. El-Ali J, Sorger PK, Jensen KF. Cells on chips. Nature. 2006 Jul 27; 442(7101):403-11.
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  75. Draviam VM, Shapiro I, Aldridge B, Sorger PK. Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. EMBO J. 2006 Jun 21; 25(12):2814-27.
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  76. Wei RR, Schnell JR, Larsen NA, Sorger PK, Chou JJ, Harrison SC. Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain. Structure. 2006 Jun; 14(6):1003-9.
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  77. Janes KA, Gaudet S, Albeck JG, Nielsen UB, Lauffenburger DA, Sorger PK. The response of human epithelial cells to TNF involves an inducible autocrine cascade. Cell. 2006 Mar 24; 124(6):1225-39.
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  78. Meraldi P, McAinsh AD, Rheinbay E, Sorger PK. Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins. Genome Biol. 2006; 7(3):R23.
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  79. Tytell JD, Sorger PK. Analysis of kinesin motor function at budding yeast kinetochores. J Cell Biol. 2006 Mar 13; 172(6):861-74.
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  80. Schoeberl B, Pace E, Howard S, Garantcharova V, Kudla A, Sorger PK, Nielsen UB. A data-driven computational model of the ErbB receptor signaling network. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:53-4.
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  81. Janes KA, Albeck JG, Gaudet S, Sorger PK, Lauffenburger DA, Yaffe MB. A systems model of signaling identifies a molecular basis set for cytokine-induced apoptosis. Science. 2005 Dec 9; 310(5754):1646-53.
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  82. Dorn JF, Jaqaman K, Rines DR, Jelson GS, Sorger PK, Danuser G. Yeast kinetochore microtubule dynamics analyzed by high-resolution three-dimensional microscopy. Biophys J. 2005 Oct; 89(4):2835-54.
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  83. Burds AA, Lutum AS, Sorger PK. Generating chromosome instability through the simultaneous deletion of Mad2 and p53. Proc Natl Acad Sci U S A. 2005 Aug 9; 102(32):11296-301.
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  84. Gaudet S, Janes KA, Albeck JG, Pace EA, Lauffenburger DA, Sorger PK. A compendium of signals and responses triggered by prodeath and prosurvival cytokines. Mol Cell Proteomics. 2005 Oct; 4(10):1569-90.
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  85. El-Ali J, Gaudet S, Günther A, Sorger PK, Jensen KF. Cell stimulus and lysis in a microfluidic device with segmented gas-liquid flow. Anal Chem. 2005 Jun 1; 77(11):3629-36.
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  86. Goldberg IG, Allan C, Burel JM, Creager D, Falconi A, Hochheiser H, Johnston J, Mellen J, Sorger PK, Swedlow JR. The Open Microscopy Environment (OME) Data Model and XML file: open tools for informatics and quantitative analysis in biological imaging. Genome Biol. 2005; 6(5):R47.
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  87. Wei RR, Sorger PK, Harrison SC. Molecular organization of the Ndc80 complex, an essential kinetochore component. Proc Natl Acad Sci U S A. 2005 Apr 12; 102(15):5363-7.
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  88. Hagan RS, Sorger PK. Cell biology: the more MAD, the merrier. Nature. 2005 Mar 31; 434(7033):575-7.
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  89. Meraldi P, Sorger PK. A dual role for Bub1 in the spindle checkpoint and chromosome congression. EMBO J. 2005 Apr 20; 24(8):1621-33.
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  90. Sorger PK. A reductionist's systems biology: opinion. Curr Opin Cell Biol. 2005 Feb; 17(1):9-11.
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  91. Miranda JJ, De Wulf P, Sorger PK, Harrison SC. The yeast DASH complex forms closed rings on microtubules. Nat Struct Mol Biol. 2005 Feb; 12(2):138-43.
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  92. Meraldi P, Draviam VM, Sorger PK. Timing and checkpoints in the regulation of mitotic progression. Dev Cell. 2004 Jul; 7(1):45-60.
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  93. Draviam VM, Xie S, Sorger PK. Chromosome segregation and genomic stability. Curr Opin Genet Dev. 2004 Apr; 14(2):120-5.
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  94. Gillett ES, Espelin CW, Sorger PK. Spindle checkpoint proteins and chromosome-microtubule attachment in budding yeast. J Cell Biol. 2004 Feb 16; 164(4):535-46.
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  95. Janes KA, Kelly JR, Gaudet S, Albeck JG, Sorger PK, Lauffenburger DA. Cue-signal-response analysis of TNF-induced apoptosis by partial least squares regression of dynamic multivariate data. J Comput Biol. 2004; 11(4):544-61.
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  96. De Wulf P, McAinsh AD, Sorger PK. Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev. 2003 Dec 1; 17(23):2902-21.
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  97. Espelin CW, Simons KT, Harrison SC, Sorger PK. Binding of the essential Saccharomyces cerevisiae kinetochore protein Ndc10p to CDEII. Mol Biol Cell. 2003 Nov; 14(11):4557-68.
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  98. Thomann D, Dorn J, Sorger PK, Danuser G. Automatic fluorescent tag localization II: Improvement in super-resolution by relative tracking. J Microsc. 2003 Sep; 211(Pt 3):230-48.
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  99. Nielsen UB, Cardone MH, Sinskey AJ, MacBeath G, Sorger PK. Profiling receptor tyrosine kinase activation by using Ab microarrays. Proc Natl Acad Sci U S A. 2003 Aug 5; 100(16):9330-5.
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  100. Janes KA, Albeck JG, Peng LX, Sorger PK, Lauffenburger DA, Yaffe MB. A high-throughput quantitative multiplex kinase assay for monitoring information flow in signaling networks: application to sepsis-apoptosis. Mol Cell Proteomics. 2003 Jul; 2(7):463-73.
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  101. Swedlow JR, Goldberg I, Brauner E, Sorger PK. Informatics and quantitative analysis in biological imaging. Science. 2003 Apr 4; 300(5616):100-2.
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  102. McAinsh AD, Tytell JD, Sorger PK. Structure, function, and regulation of budding yeast kinetochores. Annu Rev Cell Dev Biol. 2003; 19:519-39.
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  103. Fritz J, Cooper EB, Gaudet S, Sorger PK, Manalis SR. Electronic detection of DNA by its intrinsic molecular charge. Proc Natl Acad Sci U S A. 2002 Oct 29; 99(22):14142-6.
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  104. Thomann D, Rines DR, Sorger PK, Danuser G. Automatic fluorescent tag detection in 3D with super-resolution: application to the analysis of chromosome movement. J Microsc. 2002 Oct; 208(Pt 1):49-64.
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  105. Sachs K, Gifford D, Jaakkola T, Sorger P, Lauffenburger DA. Bayesian network approach to cell signaling pathway modeling. Sci STKE. 2002 Sep 3; 2002(148):pe38.
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  106. Rines DR, He X, Sorger PK. Quantitative microscopy of green fluorescent protein-labeled yeast. Methods Enzymol. 2002; 351:16-34.
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  107. Gillett ES, Sorger PK. Tracing the pathway of spindle assembly checkpoint signaling. Dev Cell. 2001 Aug; 1(2):162-4.
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  108. Brown CS, Goodwin PC, Sorger PK. Image metrics in the statistical analysis of DNA microarray data. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):8944-9.
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  109. He X, Rines DR, Espelin CW, Sorger PK. Molecular analysis of kinetochore-microtubule attachment in budding yeast. Cell. 2001 Jul 27; 106(2):195-206.
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  110. Kaplan KB, Burds AA, Swedlow JR, Bekir SS, Sorger PK, Näthke IS. A role for the Adenomatous Polyposis Coli protein in chromosome segregation. Nat Cell Biol. 2001 Apr; 3(4):429-32.
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  111. Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV, Benezra R. MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells. Nature. 2001 Jan 18; 409(6818):355-9.
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  112. He X, Asthana S, Sorger PK. Transient sister chromatid separation and elastic deformation of chromosomes during mitosis in budding yeast. Cell. 2000 Jun 23; 101(7):763-75.
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  113. Dobles M, Liberal V, Scott ML, Benezra R, Sorger PK. Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2. Cell. 2000 Jun 9; 101(6):635-45.
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  114. Dobles M, Sorger PK. Mitotic checkpoints, genetic instability, and cancer. Cold Spring Harb Symp Quant Biol. 2000; 65:361-8.
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  115. Norman TC, Smith DL, Sorger PK, Drees BL, O'Rourke SM, Hughes TR, Roberts CJ, Friend SH, Fields S, Murray AW. Genetic selection of peptide inhibitors of biological pathways. Science. 1999 Jul 23; 285(5427):591-5.
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  116. Martinez-Exposito MJ, Kaplan KB, Copeland J, Sorger PK. Retention of the BUB3 checkpoint protein on lagging chromosomes. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8493-8.
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  117. Russell ID, Grancell AS, Sorger PK. The unstable F-box protein p58-Ctf13 forms the structural core of the CBF3 kinetochore complex. J Cell Biol. 1999 May 31; 145(5):933-50.
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  118. Sassoon I, Severin FF, Andrews PD, Taba MR, Kaplan KB, Ashford AJ, Stark MJ, Sorger PK, Hyman AA. Regulation of Saccharomyces cerevisiae kinetochores by the type 1 phosphatase Glc7p. Genes Dev. 1999 Mar 1; 13(5):545-55.
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  119. Severin F, Kaplan K, Sorger P, Hyman T. In vitro assays for studying Saccharomyces cerevisiae kinetochore activity. Methods Cell Biol. 1999; 61:145-53.
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  120. Grancell A, Sorger PK. Chromosome movement: kinetochores motor along. Curr Biol. 1998 May 21; 8(11):R382-5.
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  121. Wiens GR, Sorger PK. Centromeric chromatin and epigenetic effects in kinetochore assembly. Cell. 1998 May 1; 93(3):313-6.
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  122. Espelin CW, Kaplan KB, Sorger PK. Probing the architecture of a simple kinetochore using DNA-protein crosslinking. J Cell Biol. 1997 Dec 15; 139(6):1383-96.
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  123. Sorger PK, Dobles M, Tournebize R, Hyman AA. Coupling cell division and cell death to microtubule dynamics. Curr Opin Cell Biol. 1997 Dec; 9(6):807-14.
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  124. Kaplan KB, Hyman AA, Sorger PK. Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation. Cell. 1997 Nov 14; 91(4):491-500.
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  125. Severin FF, Sorger PK, Hyman AA. Kinetochores distinguish GTP from GDP forms of the microtubule lattice. Nature. 1997 Aug 28; 388(6645):888-91.
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  126. Sorger PK, Doheny KF, Hieter P, Kopski KM, Huffaker TC, Hyman AA. Two genes required for the binding of an essential Saccharomyces cerevisiae kinetochore complex to DNA. Proc Natl Acad Sci U S A. 1995 Dec 19; 92(26):12026-30.
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  127. Hyman AA, Sorger PK. Structure and function of kinetochores in budding yeast. Annu Rev Cell Dev Biol. 1995; 11:471-95.
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  128. Sorger PK, Severin FF, Hyman AA. Factors required for the binding of reassembled yeast kinetochores to microtubules in vitro. J Cell Biol. 1994 Nov; 127(4):995-1008.
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  129. Doheny KF, Sorger PK, Hyman AA, Tugendreich S, Spencer F, Hieter P. Identification of essential components of the S. cerevisiae kinetochore. Cell. 1993 May 21; 73(4):761-74.
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  130. Sorger PK, Murray AW. S-phase feedback control in budding yeast independent of tyrosine phosphorylation of p34cdc28. Nature. 1992 Jan 23; 355(6358):365-8.
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  131. Sorger PK. Heat shock factor and the heat shock response. Cell. 1991 May 3; 65(3):363-6.
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  132. Sorger PK. Yeast heat shock factor contains separable transient and sustained response transcriptional activators. Cell. 1990 Aug 24; 62(4):793-805.
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  133. Sorger PK, Nelson HC. Trimerization of a yeast transcriptional activator via a coiled-coil motif. Cell. 1989 Dec 1; 59(5):807-13.
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  134. Sorger PK, Pelham HR. Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell. 1988 Sep 9; 54(6):855-64.
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  135. Sorger PK, Pelham HR. Purification and characterization of a heat-shock element binding protein from yeast. EMBO J. 1987 Oct; 6(10):3035-41.
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  136. Sorger PK, Lewis MJ, Pelham HR. Heat shock factor is regulated differently in yeast and HeLa cells. Nature. 1987 Sep 3-9; 329(6134):81-4.
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  137. Sorger PK, Pelham HR. Cloning and expression of a gene encoding hsc73, the major hsp70-like protein in unstressed rat cells. EMBO J. 1987 Apr; 6(4):993-8.
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  138. Sorger PK, Pelham HR. The glucose-regulated protein grp94 is related to heat shock protein hsp90. J Mol Biol. 1987 Mar 20; 194(2):341-4.
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  139. Sorger PK, Stockley PG, Harrison SC. Structure and assembly of turnip crinkle virus. II. Mechanism of reassembly in vitro. J Mol Biol. 1986 Oct 20; 191(4):639-58.
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  140. Sorger PK, Crowther RA, Finch JT, Pearse BM. Clathrin cubes: an extreme variant of the normal cage. J Cell Biol. 1986 Oct; 103(4):1213-9.
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