 Howard Lee Weiner, M.D.
| Title | Robert L. Kroc Professor of Neurology |
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| Institution | Brigham and Women's Hospital |
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| Department | Neurology |
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| Address | Brigham and Women
CND/HIM - Room 730
77 Avenue Louis Pasteur
Boston MA 02115
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| Phone | 617/525-5300 |
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| Fax | 617/525-5252 |
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 Mentoring CD11b+Ly6C+ monocyte response following transient focal cerebral ischemia Summer, 02/13/09 - 01/31/10 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Faculty can login to make corrections and additions.
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Sotnikov I, Veremeyko T, Starossom SC, Barteneva N, Weiner HL, Ponomarev ED. Platelets recognize brain-specific glycolipid structures, respond to neurovascular damage and promote neuroinflammation. PLoS One. 2013; 8(3):e58979.
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Bove R, Secor E, Healy BC, Musallam A, Vaughan T, Glanz BI, Greeke E, Weiner HL, Chitnis T, Wicks P, De Jager PL. Evaluation of an Online Platform for Multiple Sclerosis Research: Patient Description, Validation of Severity Scale, and Exploration of BMI Effects on Disease Course. PLoS One. 2013; 8(3):e59707.
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Hu D, Weiner HL, Ritz J. Identification of Cytolytic CD161(-)CD56(+) Regulatory CD8 T Cells in Human Peripheral Blood. PLoS One. 2013; 8(3):e59545.
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Chalifoux JR, Perry N, Katz JS, Wiggins GC, Roth J, Miles D, Devinsky O, Weiner HL, Milla SS. The ability of high field strength 7-T magnetic resonance imaging to reveal previously uncharacterized brain lesions in patients with tuberous sclerosis complex. J Neurosurg Pediatr. 2013 Mar; 11(3):268-73.
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Stankiewicz JM, Kolb H, Karni A, Weiner HL. Role of immunosuppressive therapy for the treatment of multiple sclerosis. Neurotherapeutics. 2013 Jan; 10(1):77-88.
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Murugaiyan G, Beynon V, Pires Da Cunha A, Joller N, Weiner HL. IFN-? Limits Th9-Mediated Autoimmune Inflammation through Dendritic Cell Modulation of IL-27. J Immunol. 2012 Dec 1; 189(11):5277-83.
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Cohen JA, Coles AJ, Arnold DL, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Fisher E, Brinar VV, Giovannoni G, Stojanovic M, Ertik BI, Lake SL, Margolin DH, Panzara MA, Compston DA. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial. Lancet. 2012 Nov 24; 380(9856):1819-28.
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Coles AJ, Twyman CL, Arnold DL, Cohen JA, Confavreux C, Fox EJ, Hartung HP, Havrdova E, Selmaj KW, Weiner HL, Miller T, Fisher E, Sandbrink R, Lake SL, Margolin DH, Oyuela P, Panzara MA, Compston DA. Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial. Lancet. 2012 Nov 24; 380(9856):1829-39.
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Chen L, Chen Z, Baker K, Halvorsen EM, Pires da Cunha A, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS. The Short Isoform of the CEACAM1 Receptor in Intestinal T Cells Regulates Mucosal Immunity and Homeostasis via Tfh Cell Induction. Immunity. 2012 Nov 16; 37(5):930-46.
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Glanz BI, Dégano IR, Rintell DJ, Chitnis T, Weiner HL, Healy BC. Work productivity in relapsing multiple sclerosis: associations with disability, depression, fatigue, anxiety, cognition, and health-related quality of life. Value Health. 2012 Dec; 15(8):1029-35.
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Ottoboni L, Keenan BT, Tamayo P, Kuchroo M, Mesirov JP, Buckle GJ, Khoury SJ, Hafler DA, Weiner HL, De Jager PL. An RNA profile identifies two subsets of multiple sclerosis patients differing in disease activity. Sci Transl Med. 2012 Sep 26; 4(153):153ra131.
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Vaughn J, Hagiwara M, Katz J, Roth J, Devinsky O, Weiner H, Milla S. MRI characterization and longitudinal study of focal cerebellar lesions in a young tuberous sclerosis cohort. AJNR Am J Neuroradiol. 2013 Mar; 34(3):655-9.
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Rezende RM, Oliveira RP, Medeiros SR, Gomes-Santos AC, Alves AC, Loli FG, Guimarães MA, Amaral SS, da Cunha AP, Weiner HL, Azevedo V, Miyoshi A, Faria AM. Hsp65-producing Lactococcus lactis prevents experimental autoimmune encephalomyelitis in mice by inducing CD4+LAP+ regulatory T cells. J Autoimmun. 2013 Feb; 40:45-57.
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Butovsky O, Siddiqui S, Gabriely G, Lanser AJ, Dake B, Murugaiyan G, Doykan CE, Wu PM, Gali RR, Iyer LK, Lawson R, Berry J, Krichevsky AM, Cudkowicz ME, Weiner HL. Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest. 2012 Sep 4; 122(9):3063-87.
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Veremeyko T, Starossom SC, Weiner HL, Ponomarev ED. Detection of microRNAs in microglia by real-time PCR in normal CNS and during neuroinflammation. J Vis Exp. 2012; (65).
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Weiner HL. Role of T cells in neuromyelitis optica. Ann Neurol. 2012 Jul; 72(1):6-8.
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Mayo L, Quintana FJ, Weiner HL. The innate immune system in demyelinating disease. Immunol Rev. 2012 Jul; 248(1):170-87.
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Beynon V, Quintana FJ, Weiner HL. Activated human CD4+CD45RO+ memory T-cells indirectly inhibit NLRP3 inflammasome activation through downregulation of P2X7R signalling. PLoS One. 2012; 7(6):e39576.
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Yeste A, Nadeau M, Burns EJ, Weiner HL, Quintana FJ. Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11270-5.
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Ponomarev ED, Veremeyko T, Weiner HL. MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS. Glia. 2013 Jan; 61(1):91-103.
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Quintana FJ, Yeste A, Weiner HL, Covacu R. Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis. J Neuroimmunol. 2012 Jul 15; 248(1-2):53-7.
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Rodgers SD, Bassani L, Weiner HL, Harter DH. Stereotactic endoscopic resection and surgical management of a subependymal giant cell astrocytoma. J Neurosurg Pediatr. 2012 Apr; 9(4):417-20.
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Ceccarelli A, Jackson JS, Tauhid S, Arora A, Gorky J, Dell'Oglio E, Bakshi A, Chitnis T, Khoury SJ, Weiner HL, Guttmann CR, Bakshi R, Neema M. The impact of lesion in-painting and registration methods on voxel-based morphometry in detecting regional cerebral gray matter atrophy in multiple sclerosis. AJNR Am J Neuroradiol. 2012 Sep; 33(8):1579-85.
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Mittal A, Murugaiyan G, Beynon V, Hu D, Weiner HL. IL-27 induction of IL-21 from human CD8+ T cells induces granzyme B in an autocrine manner. Immunol Cell Biol. 2012 Sep; 90(8):831-5.
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Quintana FJ, Farez MF, Izquierdo G, Lucas M, Cohen IR, Weiner HL. Antigen microarrays identify CNS-produced autoantibodies in RRMS. Neurology. 2012 Feb 21; 78(8):532-9.
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Roth J, Olasunkanmi A, Ma TS, Carlson C, Devinsky O, Harter DH, Weiner HL. Epilepsy control following intracranial monitoring without resection in young children. Epilepsia. 2012 Feb; 53(2):334-41.
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Healy BC, Degano IR, Schreck A, Rintell D, Weiner H, Chitnis T, Glanz BI. The impact of a recent relapse on patient-reported outcomes in subjects with multiple sclerosis. Qual Life Res. 2012 Dec; 21(10):1677-84.
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Moodie J, Healy BC, Buckle GJ, Gauthier SA, Glanz BI, Arora A, Ceccarelli A, Tauhid S, Han XM, Venkataraman A, Chitnis T, Khoury SJ, Guttmann CR, Weiner HL, Neema M, Bakshi R. Magnetic resonance disease severity scale (MRDSS) for patients with multiple sclerosis: A longitudinal study. J Neurol Sci. 2012 Apr 15; 315(1-2):49-54.
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Hu D, Liu X, Zeng W, Weiner HL, Ritz J. A clonal model for human CD8+ regulatory T cells: unrestricted contact-dependent killing of activated CD4+ T cells. Eur J Immunol. 2012 Jan; 42(1):69-79.
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da Cunha AP, Weiner HL. Induction of immunological tolerance by oral anti-CD3. Clin Dev Immunol. 2012; 2012:425021.
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Laroni A, Gandhi R, Beynon V, Weiner HL. IL-27 imparts immunoregulatory function to human NK cell subsets. PLoS One. 2011; 6(10):e26173.
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Cassani B, Villablanca EJ, Quintana FJ, Love PE, Lacy-Hulbert A, Blaner WS, Sparwasser T, Snapper SB, Weiner HL, Mora JR. Gut-tropic T cells that express integrin a4ß7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology. 2011 Dec; 141(6):2109-18.
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Wu HY, Quintana FJ, da Cunha AP, Dake BT, Koeglsperger T, Starossom SC, Weiner HL. In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling. PLoS One. 2011; 6(8):e23618.
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Kappos L, Bates D, Edan G, Eraksoy M, Garcia-Merino A, Grigoriadis N, Hartung HP, Havrdová E, Hillert J, Hohlfeld R, Kremenchutzky M, Lyon-Caen O, Miller A, Pozzilli C, Ravnborg M, Saida T, Sindic C, Vass K, Clifford DB, Hauser S, Major EO, O'Connor PW, Weiner HL, Clanet M, Gold R, Hirsch HH, Radü EW, Sørensen PS, King J. Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoring. Lancet Neurol. 2011 Aug; 10(8):745-58.
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Murugaiyan G, Beynon V, Mittal A, Joller N, Weiner HL. Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis. J Immunol. 2011 Sep 1; 187(5):2213-21.
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Glanz BI, Healy BC, Hviid LE, Chitnis T, Weiner HL. Cognitive deterioration in patients with early multiple sclerosis: a 5-year study. J Neurol Neurosurg Psychiatry. 2012 Jan; 83(1):38-43.
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Gholipour T, Healy B, Baruch NF, Weiner HL, Chitnis T. Demographic and clinical characteristics of malignant multiple sclerosis. Neurology. 2011 Jun 7; 76(23):1996-2001.
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Pacione D, Blei F, Devinsky O, Weiner HL, Roth J. Coagulation abnormalities in children undergoing epilepsy surgery. J Neurosurg Pediatr. 2011 Jun; 7(6):654-9.
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Santiago AF, Alves AC, Oliveira RP, Fernandes RM, Paula-Silva J, Assis FA, Carvalho CR, Weiner HL, Faria AM. Aging correlates with reduction in regulatory-type cytokines and T cells in the gut mucosa. Immunobiology. 2011 Oct; 216(10):1085-93.
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Weiner HL, da Cunha AP, Quintana F, Wu H. Oral tolerance. Immunol Rev. 2011 May; 241(1):241-59.
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Sansa G, Carlson C, Doyle W, Weiner HL, Bluvstein J, Barr W, Devinsky O. Medically refractory epilepsy in autism. Epilepsia. 2011 Jun; 52(6):1071-5.
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Oida T, Weiner HL. Murine CD4 T cells produce a new form of TGF-ß as measured by a newly developed TGF-ß bioassay. PLoS One. 2011; 6(4):e18365.
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Stankiewicz JM, Glanz BI, Healy BC, Arora A, Neema M, Benedict RH, Guss ZD, Tauhid S, Buckle GJ, Houtchens MK, Khoury SJ, Weiner HL, Guttmann CR, Bakshi R. Brain MRI lesion load at 1.5T and 3T versus clinical status in multiple sclerosis. J Neuroimaging. 2011 Apr; 21(2):e50-6.
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Holland CM, Charil A, Csapo I, Liptak Z, Ichise M, Khoury SJ, Bakshi R, Weiner HL, Guttmann CR. The relationship between normal cerebral perfusion patterns and white matter lesion distribution in 1,249 patients with multiple sclerosis. J Neuroimaging. 2012 Apr; 22(2):129-36.
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Liguori M, Meier DS, Hildenbrand P, Healy BC, Chitnis T, Baruch NF, Khoury SJ, Weiner HL, Bakshi R, Barkhof F, Guttmann CR. One year activity on subtraction MRI predicts subsequent 4 year activity and progression in multiple sclerosis. J Neurol Neurosurg Psychiatry. 2011 Oct; 82(10):1125-31.
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Hviid LE, Healy BC, Rintell DJ, Chitnis T, Weiner HL, Glanz BI. Patient reported outcomes in benign multiple sclerosis. Mult Scler. 2011 Jul; 17(7):876-84.
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Lifshitz V, Weiss R, Benromano T, Kfir E, Blumenfeld-Katzir T, Tempel-Brami C, Assaf Y, Xia W, Wyss-Coray T, Weiner HL, Frenkel D. Immunotherapy of cerebrovascular amyloidosis in a transgenic mouse model. Neurobiol Aging. 2012 Feb; 33(2):432.e1-432.e13.
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Roth J, Olasunkanmi A, MacAllister WS, Weil E, Uy CC, Devinsky O, Weiner HL. Quality of life following epilepsy surgery for children with tuberous sclerosis complex. Epilepsy Behav. 2011 Mar; 20(3):561-5.
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Healy BC, Engler D, Gholipour T, Weiner H, Bakshi R, Chitnis T. Accounting for disease modifying therapy in models of clinical progression in multiple sclerosis. J Neurol Sci. 2011 Apr 15; 303(1-2):109-13.
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Roth J, Galeano E, Milla S, Hartmannsgruber MW, Weiner HL. Multiple epidural hematomas and hemodynamic collapse caused by a subgaleal drain and suction-induced intracranial hypotension: case report. Neurosurgery. 2011 Jan; 68(1):E271-5; discussion E276.
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Liguori M, Healy BC, Glanz BI, Khoury SJ, Moscufo N, Weiner HL, De Jager PL, Guttmann CR. HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal study. Genes Immun. 2011 Apr; 12(3):183-90.
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Ponomarev ED, Veremeyko T, Barteneva N, Krichevsky AM, Weiner HL. MicroRNA-124 promotes microglia quiescence and suppresses EAE by deactivating macrophages via the C/EBP-a-PU.1 pathway. Nat Med. 2011 Jan; 17(1):64-70.
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Balashov KE, Aung LL, Vaknin-Dembinsky A, Dhib-Jalbut S, Weiner HL. Interferon-ß inhibits toll-like receptor 9 processing in multiple sclerosis. Ann Neurol. 2010 Dec; 68(6):899-906.
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Xia Z, Chibnik LB, Glanz BI, Liguori M, Shulman JM, Tran D, Khoury SJ, Chitnis T, Holyoak T, Weiner HL, Guttmann CR, De Jager PL. A putative Alzheimer's disease risk allele in PCK1 influences brain atrophy in multiple sclerosis. PLoS One. 2010; 5(11):e14169.
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Gross R, Healy BC, Cepok S, Chitnis T, Khoury SJ, Hemmer B, Weiner HL, Hafler DA, De Jager PL. Population structure and HLA DRB1 1501 in the response of subjects with multiple sclerosis to first-line treatments. J Neuroimmunol. 2011 Apr; 233(1-2):168-74.
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Oida T, Weiner HL. TGF-ß induces surface LAP expression on murine CD4 T cells independent of Foxp3 induction. PLoS One. 2010; 5(11):e15523.
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Quintana FJ, Murugaiyan G, Farez MF, Mitsdoerffer M, Tukpah AM, Burns EJ, Weiner HL. An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20768-73.
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Vega JL, Saban D, Carrier Y, Masli S, Weiner HL. Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-ß. Ocul Immunol Inflamm. 2010 Dec; 18(6):459-69.
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Haranhalli N, Anand D, Wisoff JH, Harter DH, Weiner HL, Blate M, Roth J. Intrathecal baclofen therapy: complication avoidance and management. Childs Nerv Syst. 2011 Mar; 27(3):421-7.
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Oida T, Weiner HL. Depletion of TGF-ß from fetal bovine serum. J Immunol Methods. 2010 Oct 31; 362(1-2):195-8.
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Khoury SJ, Healy BC, Kivisäkk P, Viglietta V, Egorova S, Guttmann CR, Wedgwood JF, Hafler DA, Weiner HL, Buckle G, Cook S, Reddy S. A randomized controlled double-masked trial of albuterol add-on therapy in patients with multiple sclerosis. Arch Neurol. 2010 Sep; 67(9):1055-61.
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Meier DS, Balashov KE, Healy B, Weiner HL, Guttmann CR. Seasonal prevalence of MS disease activity. Neurology. 2010 Aug 31; 75(9):799-806.
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Healy BC, Glanz BI, Stankiewicz J, Buckle G, Weiner H, Chitnis T. A method for evaluating treatment switching criteria in multiple sclerosis. Mult Scler. 2010 Dec; 16(12):1483-9.
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Wu HY, Maron R, Tukpah AM, Weiner HL. Mucosal anti-CD3 monoclonal antibody attenuates collagen-induced arthritis that is associated with induction of LAP+ regulatory T cells and is enhanced by administration of an emulsome-based Th2-skewing adjuvant. J Immunol. 2010 Sep 15; 185(6):3401-7.
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Oida T, Weiner HL. Overexpression of TGF-ß 1 gene induces cell surface localized glucose-regulated protein 78-associated latency-associated peptide/TGF-ß. J Immunol. 2010 Sep 15; 185(6):3529-35.
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Healy BC, Liguori M, Tran D, Chitnis T, Glanz B, Wolfish C, Gauthier S, Buckle G, Houtchens M, Stazzone L, Khoury S, Hartzmann R, Fernandez-Vina M, Hafler DA, Weiner HL, Guttmann CR, De Jager PL. HLA B*44: protective effects in MS susceptibility and MRI outcome measures. Neurology. 2010 Aug 17; 75(7):634-40.
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Souweidane MM, Krieger MD, Weiner HL, Finlay JL. Surgical management of primary central nervous system germ cell tumors: proceedings from the Second International Symposium on Central Nervous System Germ Cell Tumors. J Neurosurg Pediatr. 2010 Aug; 6(2):125-30.
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Apetoh L, Quintana FJ, Pot C, Joller N, Xiao S, Kumar D, Burns EJ, Sherr DH, Weiner HL, Kuchroo VK. The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27. Nat Immunol. 2010 Sep; 11(9):854-61.
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Gandhi R, Kumar D, Burns EJ, Nadeau M, Dake B, Laroni A, Kozoriz D, Weiner HL, Quintana FJ. Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells. Nat Immunol. 2010 Sep; 11(9):846-53.
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Peron JP, Yang K, Chen ML, Brandao WN, Basso AS, Commodaro AG, Weiner HL, Rizzo LV. Oral tolerance reduces Th17 cells as well as the overall inflammation in the central nervous system of EAE mice. J Neuroimmunol. 2010 Oct 8; 227(1-2):10-7.
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Murugaiyan G, Mittal A, Weiner HL. Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. Proc Natl Acad Sci U S A. 2010 Jun 22; 107(25):11495-500.
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Godley LA, Njiaju UO, Green M, Weiner H, Lin S, Odenike O, Rich ES, Artz A, Van Besien K, Daugherty CK, Zhang Y, Le Beau MM, Stock W, Larson RA. Treatment of therapy-related myeloid neoplasms with high-dose cytarabine/mitoxantrone followed by hematopoietic stem cell transplant. Leuk Lymphoma. 2010 Jun; 51(6):995-1006.
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Hjorth E, Frenkel D, Weiner H, Schultzberg M. Effects of immunomodulatory substances on phagocytosis of abeta(1-42) by human microglia. Int J Alzheimers Dis. 2010; 2010.
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Moshel YA, Elliott R, Teutonico F, Sellin J, Carlson C, Devinsky O, Weiner HL. Do tubers contain function? Resection of epileptogenic foci in perirolandic cortex in children with tuberous sclerosis complex. Epilepsia. 2010 Jul; 51(7):1242-51.
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Ilan Y, Maron R, Tukpah AM, Maioli TU, Murugaiyan G, Yang K, Wu HY, Weiner HL. Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9765-70.
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Gandhi R, Laroni A, Weiner HL. Role of the innate immune system in the pathogenesis of multiple sclerosis. J Neuroimmunol. 2010 Apr 15; 221(1-2):7-14.
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Rodriguez-Manzanet R, Sanjuan MA, Wu HY, Quintana FJ, Xiao S, Anderson AC, Weiner HL, Green DR, Kuchroo VK. T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice. Proc Natl Acad Sci U S A. 2010 May 11; 107(19):8706-11.
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Gandhi R, Farez MF, Wang Y, Kozoriz D, Quintana FJ, Weiner HL. Cutting edge: human latency-associated peptide+ T cells: a novel regulatory T cell subset. J Immunol. 2010 May 1; 184(9):4620-4.
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Narayana A, Kunnakkat S, Chacko-Mathew J, Gardner S, Karajannis M, Raza S, Wisoff J, Weiner H, Harter D, Allen J. Bevacizumab in recurrent high-grade pediatric gliomas. Neuro Oncol. 2010 Sep; 12(9):985-90.
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Quintana FJ, Iglesias AH, Farez MF, Caccamo M, Burns EJ, Kassam N, Oukka M, Weiner HL. Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish. PLoS One. 2010; 5(3):e9478.
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Chen ML, Yan BS, Kozoriz D, Weiner HL. Novel CD8+ Treg suppress EAE by TGF-beta- and IFN-gamma-dependent mechanisms. Eur J Immunol. 2009 Dec; 39(12):3423-35.
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Glanz BI, Healy BC, Rintell DJ, Jaffin SK, Bakshi R, Weiner HL. The association between cognitive impairment and quality of life in patients with early multiple sclerosis. J Neurol Sci. 2010 Mar 15; 290(1-2):75-9.
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Elliott RE, Carlson C, Kalhorn SP, Moshel YA, Weiner HL, Devinsky O, Doyle WK. Refractory epilepsy in tuberous sclerosis: vagus nerve stimulation with or without subsequent resective surgery. Epilepsy Behav. 2009 Nov; 16(3):454-60.
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Ilan Y, Zigmond E, Lalazar G, Dembinsky A, Ben Ya'acov A, Hemed N, Kasis I, Axelrod E, Zolotarov L, Klein A, El Haj M, Gandhi R, Baecher-Allan C, Wu H, Murugaiyan G, Kivisakk P, Farez MF, Quintana FJ, Khoury SJ, Weiner HL. Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cells. J Clin Immunol. 2010 Jan; 30(1):167-77.
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Sampat MP, Berger AM, Healy BC, Hildenbrand P, Vass J, Meier DS, Chitnis T, Weiner HL, Bakshi R, Guttmann CR. Regional white matter atrophy--based classification of multiple sclerosis in cross-sectional and longitudinal data. AJNR Am J Neuroradiol. 2009 Oct; 30(9):1731-9.
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Farez MF, Quintana FJ, Gandhi R, Izquierdo G, Lucas M, Weiner HL. Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE. Nat Immunol. 2009 Sep; 10(9):958-64.
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Zota V, Nemirovsky A, Baron R, Fisher Y, Selkoe DJ, Altmann DM, Weiner HL, Monsonego A. HLA-DR alleles in amyloid beta-peptide autoimmunity: a highly immunogenic role for the DRB1*1501 allele. J Immunol. 2009 Sep 1; 183(5):3522-30.
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Elliott R, Kalhorn S, Pacione D, Weiner H, Wisoff J, Harter D. Shunt malfunction causing acute neurological deterioration in 2 patients with previously asymptomatic Chiari malformation Type I. Report of two cases. J Neurosurg Pediatr. 2009 Aug; 4(2):170-5.
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Murugaiyan G, Mittal A, Lopez-Diego R, Maier LM, Anderson DE, Weiner HL. IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells. J Immunol. 2009 Aug 15; 183(4):2435-43.
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Healy BC, Ali EN, Guttmann CR, Chitnis T, Glanz BI, Buckle G, Houtchens M, Stazzone L, Moodie J, Berger AM, Duan Y, Bakshi R, Khoury S, Weiner H, Ascherio A. Smoking and disease progression in multiple sclerosis. Arch Neurol. 2009 Jul; 66(7):858-64.
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Bollo RJ, Berliner JL, Fischer I, Miles DK, Thiele EA, Zagzag D, Weiner HL. Extraventricular subependymal giant cell tumor in a child with tuberous sclerosis complex. J Neurosurg Pediatr. 2009 Jul; 4(1):85-90.
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De Jager PL, Jia X, Wang J, de Bakker PI, Ottoboni L, Aggarwal NT, Piccio L, Raychaudhuri S, Tran D, Aubin C, Briskin R, Romano S, Baranzini SE, McCauley JL, Pericak-Vance MA, Haines JL, Gibson RA, Naeglin Y, Uitdehaag B, Matthews PM, Kappos L, Polman C, McArdle WL, Strachan DP, Evans D, Cross AH, Daly MJ, Compston A, Sawcer SJ, Weiner HL, Hauser SL, Hafler DA, Oksenberg JR. Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci. Nat Genet. 2009 Jul; 41(7):776-82.
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Frenkel D, Pachori AS, Zhang L, Dembinsky-Vaknin A, Farfara D, Petrovic-Stojkovic S, Dzau VJ, Weiner HL. Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injury. Int Immunol. 2009 Jul; 21(7):817-29.
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Kivisäkk P, Healy BC, Viglietta V, Quintana FJ, Hootstein MA, Weiner HL, Khoury SJ. Natalizumab treatment is associated with peripheral sequestration of proinflammatory T cells. Neurology. 2009 Jun 2; 72(22):1922-30.
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Wu HY, Center EM, Tsokos GC, Weiner HL. Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells. Lupus. 2009 Jun; 18(7):586-96.
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Bollo RJ, Carlson C, Schevon C, Wisoff JH, Devinsky O, Weiner HL. Extraoperative functional mapping and staged resection of supratentorial tumors near eloquent cortex in children. Pediatr Neurosurg. 2009; 45(3):175-80.
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Gauthier SA, Glanz BI, Mandel M, Tsagkaropoulos A, Neema M, Stankiewicz J, Arora A, Duan Y, Liptak Z, Egorova S, Buckle GJ, Bakshi R, Guttmann CR, Khoury SJ, Weiner HL. Incidence and factors associated with treatment failure in the CLIMB multiple sclerosis cohort study. J Neurol Sci. 2009 Sep 15; 284(1-2):116-9.
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Neema M, Goldberg-Zimring D, Guss ZD, Healy BC, Guttmann CR, Houtchens MK, Weiner HL, Horsfield MA, Hackney DB, Alsop DC, Bakshi R. 3 T MRI relaxometry detects T2 prolongation in the cerebral normal-appearing white matter in multiple sclerosis. Neuroimage. 2009 Jul 1; 46(3):633-41.
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Weiner HL. The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease? Ann Neurol. 2009 Mar; 65(3):239-48.
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Quintana FJ, Weiner HL. Environmental control of Th17 differentiation. Eur J Immunol. 2009 Mar; 39(3):655-7.
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De Jager PL, Baecher-Allan C, Maier LM, Arthur AT, Ottoboni L, Barcellos L, McCauley JL, Sawcer S, Goris A, Saarela J, Yelensky R, Price A, Leppa V, Patterson N, de Bakker PI, Tran D, Aubin C, Pobywajlo S, Rossin E, Hu X, Ashley CW, Choy E, Rioux JD, Pericak-Vance MA, Ivinson A, Booth DR, Stewart GJ, Palotie A, Peltonen L, Dubois B, Haines JL, Weiner HL, Compston A, Hauser SL, Daly MJ, Reich D, Oksenberg JR, Hafler DA. The role of the CD58 locus in multiple sclerosis. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5264-9.
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Yang K, Vega JL, Hadzipasic M, Schatzmann Peron JP, Zhu B, Carrier Y, Masli S, Rizzo LV, Weiner HL. Deficiency of thrombospondin-1 reduces Th17 differentiation and attenuates experimental autoimmune encephalomyelitis. J Autoimmun. 2009 Mar; 32(2):94-103.
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Gauthier SA, Berger AM, Liptak Z, Duan Y, Egorova S, Buckle GJ, Glanz BI, Khoury SJ, Bakshi R, Weiner HL, Guttmann CR. Rate of brain atrophy in benign vs early multiple sclerosis. Arch Neurol. 2009 Feb; 66(2):234-7.
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Ali EN, Healy BC, Stazzone LA, Brown BA, Weiner HL, Khoury SJ. Daclizumab in treatment of multiple sclerosis patients. Mult Scler. 2009 Feb; 15(2):272-4.
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Neema M, Arora A, Healy BC, Guss ZD, Brass SD, Duan Y, Buckle GJ, Glanz BI, Stazzone L, Khoury SJ, Weiner HL, Guttmann CR, Bakshi R. Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis. J Neuroimaging. 2009 Jan; 19(1):3-8.
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Murugaiyan G, Mittal A, Weiner HL. Increased osteopontin expression in dendritic cells amplifies IL-17 production by CD4+ T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis. J Immunol. 2008 Dec 1; 181(11):7480-8.
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Quintana FJ, Farez MF, Viglietta V, Iglesias AH, Merbl Y, Izquierdo G, Lucas M, Basso AS, Khoury SJ, Lucchinetti CF, Cohen IR, Weiner HL. Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis. Proc Natl Acad Sci U S A. 2008 Dec 2; 105(48):18889-94.
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Bakshi R, Neema M, Healy BC, Liptak Z, Betensky RA, Buckle GJ, Gauthier SA, Stankiewicz J, Meier D, Egorova S, Arora A, Guss ZD, Glanz B, Khoury SJ, Guttmann CR, Weiner HL. Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale. Arch Neurol. 2008 Nov; 65(11):1449-53.
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Lopez-Diego RS, Weiner HL. Novel therapeutic strategies for multiple sclerosis--a multifaceted adversary. Nat Rev Drug Discov. 2008 Nov; 7(11):909-25.
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Wu HY, Quintana FJ, Weiner HL. Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells. J Immunol. 2008 Nov 1; 181(9):6038-50.
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Levine S, Garfein ES, Weiner H, Yaremchuk MJ, Saadeh PB, Gurtner G, Levine JP, Warren SM. Intracranial microvascular free flaps. J Reconstr Microsurg. 2009 Feb; 25(2):89-95.
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Ochi H, Abraham M, Ishikawa H, Frenkel D, Yang K, Basso A, Wu H, Chen ML, Gandhi R, Miller A, Maron R, Weiner HL. New immunosuppressive approaches: oral administration of CD3-specific antibody to treat autoimmunity. J Neurol Sci. 2008 Nov 15; 274(1-2):9-12.
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Viglietta V, Bourcier K, Buckle GJ, Healy B, Weiner HL, Hafler DA, Egorova S, Guttmann CR, Rusche JR, Khoury SJ. CTLA4Ig treatment in patients with multiple sclerosis: an open-label, phase 1 clinical trial. Neurology. 2008 Sep 16; 71(12):917-24.
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Bollo RJ, Kalhorn SP, Carlson C, Haegeli V, Devinsky O, Weiner HL. Epilepsy surgery and tuberous sclerosis complex: special considerations. Neurosurg Focus. 2008 Sep; 25(3):E13.
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Teutonico F, Mai R, Devinsky O, Lo Russo G, Weiner HL, Borrelli P, Balottin U, Veggiotti P. Epilepsy surgery in tuberous sclerosis complex: early predictive elements and outcome. Childs Nerv Syst. 2008 Dec; 24(12):1437-45.
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Weiner HL. Oral laquinimod for treatment of relapsing-remitting multiple sclerosis. Lancet Neurol. 2008 Aug; 7(8):672-3.
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Fischer I, Cunliffe C, Bollo RJ, Weiner HL, Devinsky O, Ruiz-Tachiquin ME, Venuto T, Pearlman A, Chiriboga L, Schneider RJ, Ostrer H, Miller DC. Glioma-like proliferation within tissues excised as tubers in patients with tuberous sclerosis complex. Acta Neuropathol. 2008 Jul; 116(1):67-77.
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De Jager PL, Rossin E, Pyne S, Tamayo P, Ottoboni L, Viglietta V, Weiner M, Soler D, Izmailova E, Faron-Yowe L, O'Brien C, Freeman S, Granados S, Parker A, Roubenoff R, Mesirov JP, Khoury SJ, Hafler DA, Weiner HL. Cytometric profiling in multiple sclerosis uncovers patient population structure and a reduction of CD8low cells. Brain. 2008 Jul; 131(Pt 7):1701-11.
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Liptak Z, Berger AM, Sampat MP, Charil A, Felsovalyi O, Healy BC, Hildenbrand P, Khoury SJ, Weiner HL, Bakshi R, Guttmann CR. Medulla oblongata volume: a biomarker of spinal cord damage and disability in multiple sclerosis. AJNR Am J Neuroradiol. 2008 Sep; 29(8):1465-70.
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Chen ML, Yan BS, Bando Y, Kuchroo VK, Weiner HL. Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J Immunol. 2008 Jun 1; 180(11):7327-37.
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Quintana FJ, Farez MF, Weiner HL. Systems biology approaches for the study of multiple sclerosis. J Cell Mol Med. 2008 Aug; 12(4):1087-93.
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Frenkel D, Puckett L, Petrovic S, Xia W, Chen G, Vega J, Dembinsky-Vaknin A, Shen J, Plante M, Burt DS, Weiner HL. A nasal proteosome adjuvant activates microglia and prevents amyloid deposition. Ann Neurol. 2008 May; 63(5):591-601.
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Vaknin-Dembinsky A, Murugaiyan G, Hafler DA, Astier AL, Weiner HL. Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis. J Neuroimmunol. 2008 Mar; 195(1-2):140-5.
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Basso AS, Frenkel D, Quintana FJ, Costa-Pinto FA, Petrovic-Stojkovic S, Puckett L, Monsonego A, Bar-Shir A, Engel Y, Gozin M, Weiner HL. Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis. J Clin Invest. 2008 Apr; 118(4):1532-43.
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Vaknin-Dembinsky A, Brass SD, Brass S, Gandhi R, Weiner HL. Membrane bound IL-15 is increased on CD14 monocytes in early stages of MS. J Neuroimmunol. 2008 Mar; 195(1-2):135-9.
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Quintana FJ, Basso AS, Iglesias AH, Korn T, Farez MF, Bettelli E, Caccamo M, Oukka M, Weiner HL. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature. 2008 May 1; 453(7191):65-71.
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Weiner HL. A shift from adaptive to innate immunity: a potential mechanism of disease progression in multiple sclerosis. J Neurol. 2008 Mar; 255 Suppl 1:3-11.
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Abraham M, Karni A, Dembinsky A, Miller A, Gandhi R, Anderson D, Weiner HL. In vitro induction of regulatory T cells by anti-CD3 antibody in humans. J Autoimmun. 2008 Feb-Mar; 30(1-2):21-8.
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Sayegh MH, Weiner HL. Regulating rejection with cell therapy. Nat Biotechnol. 2008 Feb; 26(2):191-2.
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Bauman JA, Feoli E, Romanelli P, Doyle WK, Devinsky O, Weiner HL. Multistage epilepsy surgery: safety, efficacy, and utility of a novel approach in pediatric extratemporal epilepsy. Neurosurgery. 2008 Feb; 62 Suppl 2:489-505.
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Boster A, Edan G, Frohman E, Javed A, Stuve O, Tselis A, Weiner H, Weinstock-Guttman B, Khan O. Intense immunosuppression in patients with rapidly worsening multiple sclerosis: treatment guidelines for the clinician. Lancet Neurol. 2008 Feb; 7(2):173-83.
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Sosunov AA, Wu X, Weiner HL, Mikell CB, Goodman RR, Crino PD, McKhann GM. Tuberous sclerosis: a primary pathology of astrocytes? Epilepsia. 2008; 49 Suppl 2:53-62.
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Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, Kuchroo VK, Oukka M, Weiner HL. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol. 2007 Dec; 8(12):1380-9.
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Meier DS, Weiner HL, Guttmann CR. MR imaging intensity modeling of damage and repair in multiple sclerosis: relationship of short-term lesion recovery to progression and disability. AJNR Am J Neuroradiol. 2007 Nov-Dec; 28(10):1956-63.
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Post NH, Wisoff JH, Thorne CH, Weiner HL. Transient syringomyelia leading to acute neurological deterioration after repair of a lipomyelomeningocele: case report. Neurosurgery. 2007 Aug; 61(2):E426; discussion E426.
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Bluestone JA, Thomson AW, Shevach EM, Weiner HL. What does the future hold for cell-based tolerogenic therapy? Nat Rev Immunol. 2007 Aug; 7(8):650-4.
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Glanz BI, Holland CM, Gauthier SA, Amunwa EL, Liptak Z, Houtchens MK, Sperling RA, Khoury SJ, Guttmann CR, Weiner HL. Cognitive dysfunction in patients with clinically isolated syndromes or newly diagnosed multiple sclerosis. Mult Scler. 2007 Sep; 13(8):1004-10.
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Madhavan D, Weiner HL, Carlson C, Devinsky O, Kuzniecky R. Local epileptogenic networks in tuberous sclerosis complex: a case review. Epilepsy Behav. 2007 Aug; 11(1):140-6.
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Meier DS, Weiner HL, Guttmann CR. Time-series modeling of multiple sclerosis disease activity: a promising window on disease progression and repair potential? Neurotherapeutics. 2007 Jul; 4(3):485-98.
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Gauthier SA, Mandel M, Guttmann CR, Glanz BI, Khoury SJ, Betensky RA, Weiner HL. Predicting short-term disability in multiple sclerosis. Neurology. 2007 Jun 12; 68(24):2059-65.
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Vaknin-Dembinsky A, Weiner HL. Relationship of immunologic abnormalities and disease stage in multiple sclerosis: implications for therapy. J Neurol Sci. 2007 Aug 15; 259(1-2):90-4.
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Kappos L, Bates D, Hartung HP, Havrdova E, Miller D, Polman CH, Ravnborg M, Hauser SL, Rudick RA, Weiner HL, O'Connor PW, King J, Radue EW, Yousry T, Major EO, Clifford DB. Natalizumab treatment for multiple sclerosis: recommendations for patient selection and monitoring. Lancet Neurol. 2007 May; 6(5):431-41.
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Madhavan D, Schaffer S, Yankovsky A, Arzimanoglou A, Renaldo F, Zaroff CM, LaJoie J, Weiner HL, Andermann E, Franz DN, Leonard J, Connolly M, Cascino GD, Devinsky O. Surgical outcome in tuberous sclerosis complex: a multicenter survey. Epilepsia. 2007 Aug; 48(8):1625-8.
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Ishikawa H, Ochi H, Chen ML, Frenkel D, Maron R, Weiner HL. Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody. Diabetes. 2007 Aug; 56(8):2103-9.
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Gandhi R, Anderson DE, Weiner HL. Cutting Edge: Immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-beta-dependent manner. J Immunol. 2007 Apr 1; 178(7):4017-21.
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Schevon CA, Cappell J, Emerson R, Isler J, Grieve P, Goodman R, McKhann G, Weiner H, Doyle W, Kuzniecky R, Devinsky O, Gilliam F. Cortical abnormalities in epilepsy revealed by local EEG synchrony. Neuroimage. 2007 Mar; 35(1):140-8.
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Wenzel P, Hink U, Oelze M, Seeling A, Isse T, Bruns K, Steinhoff L, Brandt M, Kleschyov AL, Schulz E, Lange K, Weiner H, Lehmann J, Lackner KJ, Kawamoto T, Münzel T, Daiber A. Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice. Br J Pharmacol. 2007 Feb; 150(4):526-33.
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Carrier Y, Yuan J, Kuchroo VK, Weiner HL. Th3 cells in peripheral tolerance. II. TGF-beta-transgenic Th3 cells rescue IL-2-deficient mice from autoimmunity. J Immunol. 2007 Jan 1; 178(1):172-8.
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Carrier Y, Yuan J, Kuchroo VK, Weiner HL. Th3 cells in peripheral tolerance. I. Induction of Foxp3-positive regulatory T cells by Th3 cells derived from TGF-beta T cell-transgenic mice. J Immunol. 2007 Jan 1; 178(1):179-85.
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Karni A, Abraham M, Monsonego A, Cai G, Freeman GJ, Hafler D, Khoury SJ, Weiner HL. Innate immunity in multiple sclerosis: myeloid dendritic cells in secondary progressive multiple sclerosis are activated and drive a proinflammatory immune response. J Immunol. 2006 Sep 15; 177(6):4196-202.
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Faria AM, Weiner HL. Oral tolerance and TGF-beta-producing cells. Inflamm Allergy Drug Targets. 2006 Sep; 5(3):179-90.
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Oida T, Xu L, Weiner HL, Kitani A, Strober W. TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling. J Immunol. 2006 Aug 15; 177(4):2331-9.
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Rawle FE, Pratt KP, Labelle A, Weiner HL, Hough C, Lillicrap D. Induction of partial immune tolerance to factor VIII through prior mucosal exposure to the factor VIII C2 domain. J Thromb Haemost. 2006 Oct; 4(10):2172-9.
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Laplaud DA, Berthelot L, Miqueu P, Bourcier K, Moynard J, Oudinet Y, Guillet M, Ruiz C, Oden N, Brouard S, Guttmann CR, Weiner HL, Khoury SJ, Soulillou JP. Serial blood T cell repertoire alterations in multiple sclerosis patients; correlation with clinical and MRI parameters. J Neuroimmunol. 2006 Aug; 177(1-2):151-60.
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Vaknin-Dembinsky A, Balashov K, Weiner HL. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production. J Immunol. 2006 Jun 15; 176(12):7768-74.
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Faria AM, Weiner HL. Oral tolerance: therapeutic implications for autoimmune diseases. Clin Dev Immunol. 2006 Jun-Dec; 13(2-4):143-57.
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Ochi H, Abraham M, Ishikawa H, Frenkel D, Yang K, Basso AS, Wu H, Chen ML, Gandhi R, Miller A, Maron R, Weiner HL. Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells. Nat Med. 2006 Jun; 12(6):627-35.
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Weiner HL, Frenkel D. Immunology and immunotherapy of Alzheimer's disease. Nat Rev Immunol. 2006 May; 6(5):404-16.
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Weiner HL, Carlson C, Ridgway EB, Zaroff CM, Miles D, LaJoie J, Devinsky O. Epilepsy surgery in young children with tuberous sclerosis: results of a novel approach. Pediatrics. 2006 May; 117(5):1494-502.
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Hauser SL, Weiner HL. Natalizumab: immune effects and implications for therapy. Ann Neurol. 2006 May; 59(5):731-2.
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Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 2006 May 11; 441(7090):235-8.
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Frohman EM, Havrdova E, Lublin F, Barkhof F, Achiron A, Sharief MK, Stuve O, Racke MK, Steinman L, Weiner H, Olek M, Zivadinov R, Corboy J, Raine C, Cutter G, Richert J, Filippi M. Most patients with multiple sclerosis or a clinically isolated demyelinating syndrome should be treated at the time of diagnosis. Arch Neurol. 2006 Apr; 63(4):614-9.
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Gauthier SA, Glanz BI, Mandel M, Weiner HL. A model for the comprehensive investigation of a chronic autoimmune disease: the multiple sclerosis CLIMB study. Autoimmun Rev. 2006 Oct; 5(8):532-6.
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Monsonego A, Imitola J, Petrovic S, Zota V, Nemirovsky A, Baron R, Fisher Y, Owens T, Weiner HL. Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):5048-53.
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Zhang X, Reddy J, Ochi H, Frenkel D, Kuchroo VK, Weiner HL. Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells. Int Immunol. 2006 Apr; 18(4):495-503.
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Quintana FJ, Weiner HL. Understanding natural and pathological autoimmunity. J Neuroimmunol. 2006 May; 174(1-2):1-2.
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Gonnella PA, Chen YH, Waldner H, Weiner HL. Induction of oral tolerization in CD86 deficient mice: a role for CD86 and B cells in the up-regulation of TGF-beta. J Autoimmun. 2006 Mar; 26(2):73-81.
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Wu HY, Monsonego A, Weiner HL. The mechanism of nasal tolerance in lupus prone mice is T-cell anergy induced by immature B cells that lack B7 expression. J Autoimmun. 2006 Mar; 26(2):116-26.
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Piedimonte LR, Wailes IK, Weiner HL. Tuberous sclerosis complex: molecular pathogenesis and animal models. Neurosurg Focus. 2006; 20(1):E4.
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Zaroff CM, Morrison C, Ferraris N, Weiner HL, Miles DK, Devinsky O. Developmental outcome of epilepsy surgery in tuberous sclerosis complex. Epileptic Disord. 2005 Dec; 7(4):321-6.
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Miyamoto K, Kingsley CI, Zhang X, Jabs C, Izikson L, Sobel RA, Weiner HL, Kuchroo VK, Sharpe AH. The ICOS molecule plays a crucial role in the development of mucosal tolerance. J Immunol. 2005 Dec 1; 175(11):7341-7.
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Piedimonte LR, Wailes IK, Weiner HL. Medulloblastoma: mouse models and novel targeted therapies based on the Sonic hedgehog pathway. Neurosurg Focus. 2005 Nov; 19(5):E8.
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Smith DR, Weinstock-Guttman B, Cohen JA, Wei X, Gutmann C, Bakshi R, Olek M, Stone L, Greenberg S, Stuart D, Orav J, Stuart W, Weiner H. A randomized blinded trial of combination therapy with cyclophosphamide in patients-with active multiple sclerosis on interferon beta. Mult Scler. 2005 Oct; 11(5):573-82.
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Frohman EM, Stüve O, Havrdova E, Corboy J, Achiron A, Zivadinov R, Sorensen PS, Phillips JT, Weinshenker B, Hawker K, Hartung HP, Steinman L, Zamvil S, Cree BA, Hauser S, Weiner H, Racke MK, Filippi M. Therapeutic considerations for disease progression in multiple sclerosis: evidence, experience, and future expectations. Arch Neurol. 2005 Oct; 62(10):1519-30.
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Frenkel D, Maron R, Burt DS, Weiner HL. Nasal vaccination with a proteosome-based adjuvant and glatiramer acetate clears beta-amyloid in a mouse model of Alzheimer disease. J Clin Invest. 2005 Sep; 115(9):2423-33.
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Gauthier SA, Weiner HL. Cyclophosphamide therapy for MS. Int MS J. 2005 Aug; 12(2):52-8.
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Faria AM, Weiner HL. Oral tolerance. Immunol Rev. 2005 Aug; 206:232-59.
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Frenkel D, Huang Z, Maron R, Koldzic DN, Moskowitz MA, Weiner HL. Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke. J Neurol Sci. 2005 Jun 15; 233(1-2):125-32.
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Douglas AF, Weiner HL, Schwartz DR. Prolonged intrathecal baclofen withdrawal syndrome. Case report and discussion of current therapeutic management. J Neurosurg. 2005 Jun; 102(6):1133-6.
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Prat A, Biernacki K, Saroli T, Orav JE, Guttmann CR, Weiner HL, Khoury SJ, Antel JP. Kinin B1 receptor expression on multiple sclerosis mononuclear cells: correlation with magnetic resonance imaging T2-weighted lesion volume and clinical disability. Arch Neurol. 2005 May; 62(5):795-800.
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Abraham M, Shapiro S, Karni A, Weiner HL, Miller A. Gelatinases (MMP-2 and MMP-9) are preferentially expressed by Th1 vs. Th2 cells. J Neuroimmunol. 2005 Jun; 163(1-2):157-64.
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Bauman JA, Feoli E, Romanelli P, Doyle WK, Devinsky O, Weiner HL. Multistage epilepsy surgery: safety, efficacy, and utility of a novel approach in pediatric extratemporal epilepsy. Neurosurgery. 2005 Feb; 56(2):318-34.
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Gauthier SA, Buckle GJ, Weiner HL. Immunosuppressive therapy for multiple sclerosis. Neurol Clin. 2005 Feb; 23(1):247-72, viii-ix.
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Spector JA, Culliford AT, Post NH, Weiner H, Levine JP. An unusual case of cerebrospinal fluid pseudocyst in a previously augmented breast. Ann Plast Surg. 2005 Jan; 54(1):85-7.
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Chi SN, Gardner SL, Levy AS, Knopp EA, Miller DC, Wisoff JH, Weiner HL, Finlay JL. Feasibility and response to induction chemotherapy intensified with high-dose methotrexate for young children with newly diagnosed high-risk disseminated medulloblastoma. J Clin Oncol. 2004 Dec 15; 22(24):4881-7.
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Weiner HL. Current issues in the treatment of human diseases by mucosal tolerance. Ann N Y Acad Sci. 2004 Dec; 1029:211-24.
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Gonnella PA, Waldner HP, Kodali D, Weiner HL. Induction of low dose oral tolerance in IL-10 deficient mice with experimental autoimmune encephalomyelitis. J Autoimmun. 2004 Nov; 23(3):193-200.
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Baybis M, Yu J, Lee A, Golden JA, Weiner H, McKhann G, Aronica E, Crino PB. mTOR cascade activation distinguishes tubers from focal cortical dysplasia. Ann Neurol. 2004 Oct; 56(4):478-87.
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Weiner HL. Multiple sclerosis is an inflammatory T-cell-mediated autoimmune disease. Arch Neurol. 2004 Oct; 61(10):1613-5.
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Hara H, Monsonego A, Yuasa K, Adachi K, Xiao X, Takeda S, Takahashi K, Weiner HL, Tabira T. Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease. J Alzheimers Dis. 2004 Oct; 6(5):483-8.
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Weiner HL, Ferraris N, LaJoie J, Miles D, Devinsky O. Epilepsy surgery for children with tuberous sclerosis complex. J Child Neurol. 2004 Sep; 19(9):687-9.
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Hommes OR, Weiner HL. Clinical practice of immunosuppressive treatments in multiple sclerosis: results of a second international questionnaire. J Neurol Sci. 2004 Aug 15; 223(1):65-7.
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Weiner HL. Immunosuppressive treatment in multiple sclerosis. J Neurol Sci. 2004 Aug 15; 223(1):1-11.
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Cai G, Karni A, Oliveira EM, Weiner HL, Hafler DA, Freeman GJ. PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4+ T cells. Cell Immunol. 2004 Aug; 230(2):89-98.
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Meier DS, Weiner HL, Khoury SJ, Guttmann CR. Magnetic resonance imaging surrogates of multiple sclerosis pathology and their relationship to central nervous system atrophy. J Neuroimaging. 2004 Jul; 14(3 Suppl):46S-53S.
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Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med. 2004 Apr 5; 199(7):971-9.
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Ridgway EB, Weiner HL. Skull deformities. Pediatr Clin North Am. 2004 Apr; 51(2):359-87.
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Zhang X, Koldzic DN, Izikson L, Reddy J, Nazareno RF, Sakaguchi S, Kuchroo VK, Weiner HL. IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. Int Immunol. 2004 Feb; 16(2):249-56.
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Weiner HL. Tuberous sclerosis and multiple tubers: localizing the epileptogenic zone. Epilepsia. 2004; 45 Suppl 4:41-2.
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Klein RS, Izikson L, Means T, Gibson HD, Lin E, Sobel RA, Weiner HL, Luster AD. IFN-inducible protein 10/CXC chemokine ligand 10-independent induction of experimental autoimmune encephalomyelitis. J Immunol. 2004 Jan 1; 172(1):550-9.
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Karni A, Balashov K, Hancock WW, Bharanidharan P, Abraham M, Khoury SJ, Weiner HL. Cyclophosphamide modulates CD4+ T cells into a T helper type 2 phenotype and reverses increased IFN-gamma production of CD8+ T cells in secondary progressive multiple sclerosis. J Neuroimmunol. 2004 Jan; 146(1-2):189-98.
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Frenkel D, Huang Z, Maron R, Koldzic DN, Hancock WW, Moskowitz MA, Weiner HL. Nasal vaccination with myelin oligodendrocyte glycoprotein reduces stroke size by inducing IL-10-producing CD4+ T cells. J Immunol. 2003 Dec 15; 171(12):6549-55.
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Monsonego A, Weiner HL. Immunotherapeutic approaches to Alzheimer's disease. Science. 2003 Oct 31; 302(5646):834-8.
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Monsonego A, Imitola J, Zota V, Oida T, Weiner HL. Microglia-mediated nitric oxide cytotoxicity of T cells following amyloid beta-peptide presentation to Th1 cells. J Immunol. 2003 Sep 1; 171(5):2216-24.
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Monsonego A, Beserman ZP, Kipnis J, Yoles E, Weiner HL, Schwartz M. Beneficial effect of orally administered myelin basic protein in EAE-susceptible Lewis rats in a model of acute CNS degeneration. J Autoimmun. 2003 Sep; 21(2):131-8.
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Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. J Clin Invest. 2003 Aug; 112(3):415-22.
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Bettelli E, Pagany M, Weiner HL, Linington C, Sobel RA, Kuchroo VK. Myelin oligodendrocyte glycoprotein-specific T cell receptor transgenic mice develop spontaneous autoimmune optic neuritis. J Exp Med. 2003 May 5; 197(9):1073-81.
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Lee A, Maldonado M, Baybis M, Walsh CA, Scheithauer B, Yeung R, Parent J, Weiner HL, Crino PB. Markers of cellular proliferation are expressed in cortical tubers. Ann Neurol. 2003 May; 53(5):668-73.
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Hopfer H, Maron R, Butzmann U, Helmchen U, Weiner HL, Kalluri R. The importance of cell-mediated immunity in the course and severity of autoimmune anti-glomerular basement membrane disease in mice. FASEB J. 2003 May; 17(8):860-8.
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Kuo DJ, Weiner HL, Wisoff J, Miller DC, Knopp EA, Finlay JL. Temozolomide is active in childhood, progressive, unresectable, low-grade gliomas. J Pediatr Hematol Oncol. 2003 May; 25(5):372-8.
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Oida T, Zhang X, Goto M, Hachimura S, Totsuka M, Kaminogawa S, Weiner HL. CD4+CD25- T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism. J Immunol. 2003 Mar 1; 170(5):2516-22.
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Faria AM, Maron R, Ficker SM, Slavin AJ, Spahn T, Weiner HL. Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis. J Autoimmun. 2003 Mar; 20(2):135-45.
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Gonnella PA, Kodali D, Weiner HL. Induction of low dose oral tolerance in monocyte chemoattractant protein-1- and CCR2-deficient mice. J Immunol. 2003 Mar 1; 170(5):2316-22.
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Cotton F, Weiner HL, Jolesz FA, Guttmann CR. MRI contrast uptake in new lesions in relapsing-remitting MS followed at weekly intervals. Neurology. 2003 Feb 25; 60(4):640-6.
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Wu HY, Weiner HL. Oral tolerance. Immunol Res. 2003; 28(3):265-84.
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Spahn TW, Herbst H, Rennert PD, Lügering N, Maaser C, Kraft M, Fontana A, Weiner HL, Domschke W, Kucharzik T. Induction of colitis in mice deficient of Peyer's patches and mesenteric lymph nodes is associated with increased disease severity and formation of colonic lymphoid patches. Am J Pathol. 2002 Dec; 161(6):2273-82.
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Weiner HL, Selkoe DJ. Inflammation and therapeutic vaccination in CNS diseases. Nature. 2002 Dec 19-26; 420(6917):879-84.
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Weiner HL, Bakst R, Hurlbert MS, Ruggiero J, Ahn E, Lee WS, Stephen D, Zagzag D, Joyner AL, Turnbull DH. Induction of medulloblastomas in mice by sonic hedgehog, independent of Gli1. Cancer Res. 2002 Nov 15; 62(22):6385-9.
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Maron R, Sukhova G, Faria AM, Hoffmann E, Mach F, Libby P, Weiner HL. Mucosal administration of heat shock protein-65 decreases atherosclerosis and inflammation in aortic arch of low-density lipoprotein receptor-deficient mice. Circulation. 2002 Sep 24; 106(13):1708-15.
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Soos JM, Stüve O, Youssef S, Bravo M, Johnson HM, Weiner HL, Zamvil SS. Cutting edge: oral type I IFN-tau promotes a Th2 bias and enhances suppression of autoimmune encephalomyelitis by oral glatiramer acetate. J Immunol. 2002 Sep 1; 169(5):2231-5.
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Romanelli P, Najjar S, Weiner HL, Devinsky O. Epilepsy surgery in tuberous sclerosis: multistage procedures with bilateral or multilobar foci. J Child Neurol. 2002 Sep; 17(9):689-92.
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Siomin V, Cinalli G, Grotenhuis A, Golash A, Oi S, Kothbauer K, Weiner H, Roth J, Beni-Adani L, Pierre-Kahn A, Takahashi Y, Mallucci C, Abbott R, Wisoff J, Constantini S. Endoscopic third ventriculostomy in patients with cerebrospinal fluid infection and/or hemorrhage. J Neurosurg. 2002 Sep; 97(3):519-24.
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Izikson L, Klein RS, Luster AD, Weiner HL. Targeting monocyte recruitment in CNS autoimmune disease. Clin Immunol. 2002 May; 103(2):125-31.
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McCarthy JG, Bradley JP, Stelnicki EJ, Stokes T, Weiner HL. Hung span method of scaphocephaly reconstruction in patients with elevated intracranial pressure. Plast Reconstr Surg. 2002 May; 109(6):2009-18.
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Comabella M, Imitola J, Weiner HL, Khoury SJ. Interferon-beta treatment alters peripheral blood monocytes chemokine production in MS patients. J Neuroimmunol. 2002 May; 126(1-2):205-12.
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Karni A, Koldzic DN, Bharanidharan P, Khoury SJ, Weiner HL. IL-18 is linked to raised IFN-gamma in multiple sclerosis and is induced by activated CD4(+) T cells via CD40-CD40 ligand interactions. J Neuroimmunol. 2002 Apr; 125(1-2):134-40.
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Weiner HL, Lichtenbaum RA, Wisoff JH, Snow RB, Souweidane MM, Bruce JN, Finlay JL. Delayed surgical resection of central nervous system germ cell tumors. Neurosurgery. 2002 Apr; 50(4):727-33; discussion 733-4.
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Hommes OR, Weiner HL. Results of an international questionnaire on immunosuppressive treatment of multiple sclerosis. Mult Scler. 2002 Apr; 8(2):139-41.
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Weiner HL, Cohen JA. Treatment of multiple sclerosis with cyclophosphamide: critical review of clinical and immunologic effects. Mult Scler. 2002 Apr; 8(2):142-54.
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Spahn TW, Weiner HL, Rennert PD, Lügering N, Fontana A, Domschke W, Kucharzik T. Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches. Eur J Immunol. 2002 Apr; 32(4):1109-13.
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Maron R, Slavin AJ, Hoffmann E, Komagata Y, Weiner HL. Oral tolerance to copolymer 1 in myelin basic protein (MBP) TCR transgenic mice: cross-reactivity with MBP-specific TCR and differential induction of anti-inflammatory cytokines. Int Immunol. 2002 Feb; 14(2):131-8.
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Wei X, Warfield SK, Zou KH, Wu Y, Li X, Guimond A, Mugler JP, Benson RR, Wolfson L, Weiner HL, Guttmann CR. Quantitative analysis of MRI signal abnormalities of brain white matter with high reproducibility and accuracy. J Magn Reson Imaging. 2002 Feb; 15(2):203-9.
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Deva AK, Hopper RA, Landecker A, Flores R, Weiner H, McCarthy JG. The use of intraoperative autotransfusion during cranial vault remodeling for craniosynostosis. Plast Reconstr Surg. 2002 Jan; 109(1):58-63.
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Makhlouf K, Weiner HL, Khoury SJ. Potential of beta2-adrenoceptor agonists as add-on therapy for multiple sclerosis: focus on salbutamol (albuterol). CNS Drugs. 2002; 16(1):1-8.
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Benardete EA, Leonard MA, Weiner HL. Comparison of frameless stereotactic systems: accuracy, precision, and applications. Neurosurgery. 2001 Dec; 49(6):1409-15; discussion 1415-6.
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Dahmane N, Sánchez P, Gitton Y, Palma V, Sun T, Beyna M, Weiner H, Ruiz i Altaba A. The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis. Development. 2001 Dec; 128(24):5201-12.
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Lemere CA, Maron R, Selkoe DJ, Weiner HL. Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease. DNA Cell Biol. 2001 Nov; 20(11):705-11.
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Levine JP, Stelnicki E, Weiner HL, Bradley JP, McCarthy JG. Hyponatremia in the postoperative craniofacial pediatric patient population: a connection to cerebral salt wasting syndrome and management of the disorder. Plast Reconstr Surg. 2001 Nov; 108(6):1501-8.
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Zhang X, Izikson L, Liu L, Weiner HL. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J Immunol. 2001 Oct 15; 167(8):4245-53.
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Slavin AJ, Soos JM, Stuve O, Patarroyo JC, Weiner HL, Fontana A, Bikoff EK, Zamvil SS. Requirement for endocytic antigen processing and influence of invariant chain and H-2M deficiencies in CNS autoimmunity. J Clin Invest. 2001 Oct; 108(8):1133-9.
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Makhlouf K, Weiner HL, Khoury SJ. Increased percentage of IL-12+ monocytes in the blood correlates with the presence of active MRI lesions in MS. J Neuroimmunol. 2001 Sep 3; 119(1):145-9.
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Kopell BH, Sala D, Doyle WK, Feldman DS, Wisoff JH, Weiner HL. Subfascial implantation of intrathecal baclofen pumps in children: technical note. Neurosurgery. 2001 Sep; 49(3):753-6; discussion 756-7.
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Siomin V, Weiner H, Wisoff J, Cinalli G, Pierre-Kahn A, Saint-Rose C, Abbott R, Elran H, Beni-Adani L, Ouaknine G, Constantini S. Repeat endoscopic third ventriculostomy: is it worth trying? Childs Nerv Syst. 2001 Sep; 17(9):551-5.
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Romanelli P, Weiner HL, Najjar S, Devinsky O. Bilateral resective epilepsy surgery in a child with tuberous sclerosis: case report. Neurosurgery. 2001 Sep; 49(3):732-4; discussion 735.
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Weiner HL. Oral tolerance: immune mechanisms and the generation of Th3-type TGF-beta-secreting regulatory cells. Microbes Infect. 2001 Sep; 3(11):947-54.
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Monsonego A, Maron R, Zota V, Selkoe DJ, Weiner HL. Immune hyporesponsiveness to amyloid beta-peptide in amyloid precursor protein transgenic mice: implications for the pathogenesis and treatment of Alzheimer's disease. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10273-8.
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Weiner HL. The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells. Nat Immunol. 2001 Aug; 2(8):671-2.
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Weiner HL. Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells. Immunol Rev. 2001 Aug; 182:207-14.
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Makhlouf K, Comabella M, Imitola J, Weiner HL, Khoury SJ. Oral salbutamol decreases IL-12 in patients with secondary progressive multiple sclerosis. J Neuroimmunol. 2001 Jul 2; 117(1-2):156-65.
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Sands SA, Kellie SJ, Davidow AL, Diez B, Villablanca J, Weiner HL, Pietanza MC, Balmaceda C, Finlay JL. Long-term quality of life and neuropsychologic functioning for patients with CNS germ-cell tumors: from the First International CNS Germ-Cell Tumor Study. Neuro Oncol. 2001 Jul; 3(3):174-83.
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Yoles E, Hauben E, Palgi O, Agranov E, Gothilf A, Cohen A, Kuchroo V, Cohen IR, Weiner H, Schwartz M. Protective autoimmunity is a physiological response to CNS trauma. J Neurosci. 2001 Jun 1; 21(11):3740-8.
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Slavin AJ, Maron R, Weiner HL. Mucosal administration of IL-10 enhances oral tolerance in autoimmune encephalomyelitis and diabetes. Int Immunol. 2001 Jun; 13(6):825-33.
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Gonnella PA, Waldner HP, Weiner HL. B cell-deficient (mu MT) mice have alterations in the cytokine microenvironment of the gut-associated lymphoid tissue (GALT) and a defect in the low dose mechanism of oral tolerance. J Immunol. 2001 Apr 1; 166(7):4456-64.
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Spahn TW, Fontana A, Faria AM, Slavin AJ, Eugster HP, Zhang X, Koni PA, Ruddle NH, Flavell RA, Rennert PD, Weiner HL. Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches. Eur J Immunol. 2001 Apr; 31(4):1278-87.
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Encinas JA, Lees MB, Sobel RA, Symonowicz C, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK. Identification of genetic loci associated with paralysis, inflammation and weight loss in mouse experimental autoimmune encephalomyelitis. Int Immunol. 2001 Mar; 13(3):257-64.
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Weiner HL. The fine line between autoimmune and allergic encephalomyelitis. Nat Immunol. 2001 Mar; 2(3):193-4.
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Maron R, Guerau-de-Arellano M, Zhang X, Weiner HL. Oral administration of insulin to neonates suppresses spontaneous and cyclophosphamide induced diabetes in the NOD mouse. J Autoimmun. 2001 Feb; 16(1):21-8.
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Chu ML, Sala DA, Weiner HL. Intrathecal baclofen in X-linked adrenoleukodystrophy. Pediatr Neurol. 2001 Feb; 24(2):156-8.
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Sperling RA, Guttmann CR, Hohol MJ, Warfield SK, Jakab M, Parente M, Diamond EL, Daffner KR, Olek MJ, Orav EJ, Kikinis R, Jolesz FA, Weiner HL. Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study. Arch Neurol. 2001 Jan; 58(1):115-21.
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Weiner HL, Huang H, Zagzag D, Boyce H, Lichtenbaum R, Ziff EB. Consistent and selective expression of the discoidin domain receptor-1 tyrosine kinase in human brain tumors. Neurosurgery. 2000 Dec; 47(6):1400-9.
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Zhou J, Weiner H. Basis for half-of-the-site reactivity and the dominance of the K487 oriental subunit over the E487 subunit in heterotetrameric human liver mitochondrial aldehyde dehydrogenase. Biochemistry. 2000 Oct 3; 39(39):12019-24.
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Izikson L, Klein RS, Charo IF, Weiner HL, Luster AD. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J Exp Med. 2000 Oct 2; 192(7):1075-80.
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Weiner HL. Oral tolerance, an active immunologic process mediated by multiple mechanisms. J Clin Invest. 2000 Oct; 106(8):935-7.
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Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ. Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol. 2000 Oct; 48(4):567-79.
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Rottman JB, Slavin AJ, Silva R, Weiner HL, Gerard CG, Hancock WW. Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent. Eur J Immunol. 2000 Aug; 30(8):2372-7.
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Khoury SJ, Guttmann CR, Orav EJ, Kikinis R, Jolesz FA, Weiner HL. Changes in activated T cells in the blood correlate with disease activity in multiple sclerosis. Arch Neurol. 2000 Aug; 57(8):1183-9.
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Balashov KE, Comabella M, Ohashi T, Khoury SJ, Weiner HL. Defective regulation of IFNgamma and IL-12 by endogenous IL-10 in progressive MS. Neurology. 2000 Jul 25; 55(2):192-8.
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Golomb J, Wisoff J, Miller DC, Boksay I, Kluger A, Weiner H, Salton J, Graves W. Alzheimer's disease comorbidity in normal pressure hydrocephalus: prevalence and shunt response. J Neurol Neurosurg Psychiatry. 2000 Jun; 68(6):778-81.
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Weiner HL, Guttmann CR, Khoury SJ, Orav EJ, Hohol MJ, Kikinis R, Jolesz FA. Serial magnetic resonance imaging in multiple sclerosis: correlation with attacks, disability, and disease stage. J Neuroimmunol. 2000 May 1; 104(2):164-73.
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Houten JK, Weiner HL. Pediatric intramedullary spinal cord tumors: special considerations. J Neurooncol. 2000 May; 47(3):225-30.
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Weiner HL, Zagzag D. Growth factor receptor tyrosine kinases: cell adhesion kinase family suggests a novel signaling mechanism in cancer. Cancer Invest. 2000; 18(6):544-54.
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Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Desai R, Hancock WW, Weiner HL, Selkoe DJ. Nasal A beta treatment induces anti-A beta antibody production and decreases cerebral amyloid burden in PD-APP mice. Ann N Y Acad Sci. 2000; 920:328-31.
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Komagata Y, Weiner HL. Oral tolerance. Rev Immunogenet. 2000; 2(1):61-73.
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Schwarting A, Tesch G, Kinoshita K, Maron R, Weiner HL, Kelley VR. IL-12 drives IFN-gamma-dependent autoimmune kidney disease in MRL-Fas(lpr) mice. J Immunol. 1999 Dec 15; 163(12):6884-91.
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Karussis D, Weiner HL, Abramsky O. Multiple sclerosis vs Lyme disease: a case presentation to a discussant and a review of the literature. Mult Scler. 1999 Dec; 5(6):395-402.
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Weiner HL. Induction of oral tolerance to the acetylcholine receptor for treatment of myasthenia gravis. J Clin Invest. 1999 Dec; 104(12):1667-8.
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Hohol MJ, Olek MJ, Orav EJ, Stazzone L, Hafler DA, Khoury SJ, Dawson DM, Weiner HL. Treatment of progressive multiple sclerosis with pulse cyclophosphamide/methylprednisolone: response to therapy is linked to the duration of progressive disease. Mult Scler. 1999 Dec; 5(6):403-9.
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Spahn TW, Issazadah S, Salvin AJ, Weiner HL. Decreased severity of myelin oligodendrocyte glycoprotein peptide 33 - 35-induced experimental autoimmune encephalomyelitis in mice with a disrupted TCR delta chain gene. Eur J Immunol. 1999 Dec; 29(12):4060-71.
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Weiner HL, Finlay JL. Surgery in the management of primary intracranial germ cell tumors. Childs Nerv Syst. 1999 Nov; 15(11-12):770-3.
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Garcia G, Komagata Y, Slavin AJ, Maron R, Weiner HL. Suppression of collagen-induced arthritis by oral or nasal administration of type II collagen. J Autoimmun. 1999 Nov; 13(3):315-24.
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Hohol MJ, Orav EJ, Weiner HL. Disease steps in multiple sclerosis: a longitudinal study comparing disease steps and EDSS to evaluate disease progression. Mult Scler. 1999 Oct; 5(5):349-54.
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Diez B, Balmaceda C, Matsutani M, Weiner HL. Germ cell tumors of the CNS in children: recent advances in therapy. Childs Nerv Syst. 1999 Oct; 15(10):578-85.
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Khoury SJ, Orav EJ, Guttmann CR, Kikinis R, Jolesz FA, Weiner HL. Changes in serum levels of ICAM and TNF-R correlate with disease activity in multiple sclerosis. Neurology. 1999 Sep 11; 53(4):758-64.
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Maron R, Hancock WW, Slavin A, Hattori M, Kuchroo V, Weiner HL. Genetic susceptibility or resistance to autoimmune encephalomyelitis in MHC congenic mice is associated with differential production of pro- and anti-inflammatory cytokines. Int Immunol. 1999 Sep; 11(9):1573-80.
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Liu L, Kuchroo VK, Weiner HL. B7.2 (CD86) but not B7.1 (CD80) costimulation is required for the induction of low dose oral tolerance. J Immunol. 1999 Aug 15; 163(4):2284-90.
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Hattori M, Yamato E, Itoh N, Senpuku H, Fujisawa T, Yoshino M, Fukuda M, Matsumoto E, Toyonaga T, Nakagawa I, Petruzzelli M, McMurray A, Weiner H, Sagai T, Moriwaki K, Shiroishi T, Maron R, Lund T. Cutting edge: homologous recombination of the MHC class I K region defines new MHC-linked diabetogenic susceptibility gene(s) in nonobese diabetic mice. J Immunol. 1999 Aug 15; 163(4):1721-4.
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Weiner HL, van Rees EP. Mucosal tolerance. Immunol Lett. 1999 Jun 15; 69(1):3-4.
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Balashov KE, Rottman JB, Weiner HL, Hancock WW. CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesions. Proc Natl Acad Sci U S A. 1999 Jun 8; 96(12):6873-8.
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Maron R, Melican NS, Weiner HL. Regulatory Th2-type T cell lines against insulin and GAD peptides derived from orally- and nasally-treated NOD mice suppress diabetes. J Autoimmun. 1999 Jun; 12(4):251-8.
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Grapin-Botton A, Cambronero F, Weiner HL, Bonnin MA, Puelles L, Le Douarin NM. Patterning signals acting in the spinal cord override the organizing activity of the isthmus. Mech Dev. 1999 Jun; 84(1-2):41-53.
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Bradley JP, Hollier LH, Weiner HL, McCarthy JG. Cranial vault deformity and intracranial hypertension secondary to cephalic molding at delivery: a case and its management. J Craniofac Surg. 1999 May; 10(3):226-9.
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Ni L, Heard TS, Weiner H. In vivo mitochondrial import. A comparison of leader sequence charge and structural relationships with the in vitro model resulting in evidence for co-translational import. J Biol Chem. 1999 Apr 30; 274(18):12685-91.
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Guttmann CR, Kikinis R, Anderson MC, Jakab M, Warfield SK, Killiany RJ, Weiner HL, Jolesz FA. Quantitative follow-up of patients with multiple sclerosis using MRI: reproducibility. J Magn Reson Imaging. 1999 Apr; 9(4):509-18.
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Kikinis R, Guttmann CR, Metcalf D, Wells WM, Ettinger GJ, Weiner HL, Jolesz FA. Quantitative follow-up of patients with multiple sclerosis using MRI: technical aspects. J Magn Reson Imaging. 1999 Apr; 9(4):519-30.
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Weiner HL. Oral tolerance with copolymer 1 for the treatment of multiple sclerosis. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3333-5.
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Kappos L, Moeri D, Radue EW, Schoetzau A, Schweikert K, Barkhof F, Miller D, Guttmann CR, Weiner HL, Gasperini C, Filippi M. Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in multiple sclerosis: a meta-analysis. Gadolinium MRI Meta-analysis Group. Lancet. 1999 Mar 20; 353(9157):964-9.
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Encinas JA, Wicker LS, Peterson LB, Mukasa A, Teuscher C, Sobel R, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK. QTL influencing autoimmune diabetes and encephalomyelitis map to a 0.15-cM region containing Il2. Nat Genet. 1999 Feb; 21(2):158-60.
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Garcia G, Weiner HL. Manipulation of Th responses by oral tolerance. Curr Top Microbiol Immunol. 1999; 238:123-45.
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Faria AM, Weiner HL. Oral tolerance: mechanisms and therapeutic applications. Adv Immunol. 1999; 73:153-264.
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Weinberg JS, LeRoux PD, Panasci D, Weiner HL. Adult growing skull fracture mimicking a skull tumor. Acta Neurochir (Wien). 1999; 141(5):545-6.
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Hurley TD, Weiner H. Evaluation of the roles of the conserved residues of aldehyde dehydrogenase. Adv Exp Med Biol. 1999; 463:45-52.
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Hurley TD, Steinmetz CG, Weiner H. Three-dimensional structure of mitochondrial aldehyde dehydrogenase. Mechanistic implications. Adv Exp Med Biol. 1999; 463:15-25.
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Chen W, Jin W, Cook M, Weiner HL, Wahl SM. Oral delivery of group A streptococcal cell walls augments circulating TGF-beta and suppresses streptococcal cell wall arthritis. J Immunol. 1998 Dec 1; 161(11):6297-304.
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Windhagen A, Anderson DE, Carrizosa A, Balashov K, Weiner HL, Hafler DA. Cytokine secretion of myelin basic protein reactive T cells in patients with multiple sclerosis. J Neuroimmunol. 1998 Nov 2; 91(1-2):1-9.
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Kuchroo VK, Weiner HL. Antigen-driven regulation of experimental autoimmune encephalomyelitis. Res Immunol. 1998 Nov-Dec; 149(9):759-71; discussion 842-3, 855-60.
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Balashov KE, Olek MJ, Smith DR, Khoury SJ, Weiner HL. Seasonal variation of interferon-gamma production in progressive multiple sclerosis. Ann Neurol. 1998 Nov; 44(5):824-8.
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Bettelli E, Das MP, Howard ED, Weiner HL, Sobel RA, Kuchroo VK. IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol. 1998 Oct 1; 161(7):3299-306.
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Inobe J, Slavin AJ, Komagata Y, Chen Y, Liu L, Weiner HL. IL-4 is a differentiation factor for transforming growth factor-beta secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis. Eur J Immunol. 1998 Sep; 28(9):2780-90.
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Zamvil SS, Soos JM, Weiner HL. Pathogenesis and treatment of central nervous system demyelinating disease. Rev Neurol (Paris). 1998 Sep; 154(8-9):573-5.
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Comabella M, Balashov K, Issazadeh S, Smith D, Weiner HL, Khoury SJ. Elevated interleukin-12 in progressive multiple sclerosis correlates with disease activity and is normalized by pulse cyclophosphamide therapy. J Clin Invest. 1998 Aug 15; 102(4):671-8.
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Liu L, Rich BE, Inobe J, Chen W, Weiner HL. Induction of Th2 cell differentiation in the primary immune response: dendritic cells isolated from adherent cell culture treated with IL-10 prime naive CD4+ T cells to secrete IL-4. Int Immunol. 1998 Aug; 10(8):1017-26.
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Takashima H, Smith DR, Fukaura H, Khoury SJ, Hafler DA, Weiner HL. Pulse cyclophosphamide plus methylprednisolone induces myelin-antigen-specific IL-4-secreting T cells in multiple sclerosis patients. Clin Immunol Immunopathol. 1998 Jul; 88(1):28-34.
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Gonnella PA, Chen Y, Inobe J, Komagata Y, Quartulli M, Weiner HL. In situ immune response in gut-associated lymphoid tissue (GALT) following oral antigen in TCR-transgenic mice. J Immunol. 1998 May 15; 160(10):4708-18.
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Weiner HL. A 21 point unifying hypothesis on the etiology and treatment of multiple sclerosis. Can J Neurol Sci. 1998 May; 25(2):93-101.
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Samoilova EB, Horton JL, Zhang H, Khoury SJ, Weiner HL, Chen Y. CTLA-4 is required for the induction of high dose oral tolerance. Int Immunol. 1998 Apr; 10(4):491-8.
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Maron R, Palanivel V, Weiner HL, Harn DA. Oral administration of schistosome egg antigens and insulin B-chain generates and enhances Th2-type responses in NOD mice. Clin Immunol Immunopathol. 1998 Apr; 87(1):85-92.
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Khoury SJ, Weiner HL. Multiple sclerosis: what have we learned from magnetic resonance imaging studies? Arch Intern Med. 1998 Mar 23; 158(6):565-73.
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Chen Y, Hancock WW, Marks R, Gonnella P, Weiner HL. Mechanisms of recovery from experimental autoimmune encephalomyelitis: T cell deletion and immune deviation in myelin basic protein T cell receptor transgenic mice. J Neuroimmunol. 1998 Mar 1; 82(2):149-59.
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Liu LM, Weiner HL. T-cell response to orally administered antigens and its role in the treatment of autoimmune diseases. Chem Immunol. 1998; 71:139-60.
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Weiner HL, Komagata Y. Oral tolerance and the treatment of rheumatoid arthritis. Springer Semin Immunopathol. 1998; 20(1-2):289-308.
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Hafler DA, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Fukaura H. Oral administration of myelin induces antigen-specific TGF-beta 1 secreting T cells in patients with multiple sclerosis. Ann N Y Acad Sci. 1997 Dec 19; 835:120-31.
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Smith DR, Weiner HL. Immunologic aspects of neurologic and neuromuscular diseases. JAMA. 1997 Dec 10; 278(22):1956-61.
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Weiner HL, Gonnella PA, Slavin A, Maron R. Oral tolerance: cytokine milieu in the gut and modulation of tolerance by cytokines. Res Immunol. 1997 Oct-Dec; 148(8-9):528-33.
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Smith DR, Balashov KE, Hafler DA, Khoury SJ, Weiner HL. Immune deviation following pulse cyclophosphamide/methylprednisolone treatment of multiple sclerosis: increased interleukin-4 production and associated eosinophilia. Ann Neurol. 1997 Sep; 42(3):313-8.
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Polanski M, Melican NS, Zhang J, Weiner HL. Oral administration of the immunodominant B-chain of insulin reduces diabetes in a co-transfer model of diabetes in the NOD mouse and is associated with a switch from Th1 to Th2 cytokines. J Autoimmun. 1997 Aug; 10(4):339-46.
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Hohol MJ, Guttmann CR, Orav J, Mackin GA, Kikinis R, Khoury SJ, Jolesz FA, Weiner HL. Serial neuropsychological assessment and magnetic resonance imaging analysis in multiple sclerosis. Arch Neurol. 1997 Aug; 54(8):1018-25.
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Weiner HL, Freed D, Woo HH, Rezai AR, Kim R, Epstein FJ. Intra-axial tumors of the cervicomedullary junction: surgical results and long-term outcome. Pediatr Neurosurg. 1997 Jul; 27(1):12-8.
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Weiner HL. Oral tolerance: immune mechanisms and treatment of autoimmune diseases. Immunol Today. 1997 Jul; 18(7):335-43.
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Chen Y, Inobe J, Weiner HL. Inductive events in oral tolerance in the TCR transgenic adoptive transfer model. Cell Immunol. 1997 May 25; 178(1):62-8.
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Steinmetz CG, Xie P, Weiner H, Hurley TD. Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion. Structure. 1997 May 15; 5(5):701-11.
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Nussenblatt RB, Gery I, Weiner HL, Ferris FL, Shiloach J, Remaley N, Perry C, Caspi RR, Hafler DA, Foster CS, Whitcup SM. Treatment of uveitis by oral administration of retinal antigens: results of a phase I/II randomized masked trial. Am J Ophthalmol. 1997 May; 123(5):583-92.
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Kent SC, Fukaura H, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Oral administration of myelin induces antigen-specific TGF-beta 1-secreting T cells in multiple sclerosis patients. Ann N Y Acad Sci. 1997 Apr 5; 815:412-22.
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Balashov KE, Smith DR, Khoury SJ, Hafler DA, Weiner HL. Increased interleukin 12 production in progressive multiple sclerosis: induction by activated CD4+ T cells via CD40 ligand. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):599-603.
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Wang X, Bai Y, Ni L, Weiner H. Saccharomyces cerevisiae aldehyde dehydrogenases. Identification and expression. Adv Exp Med Biol. 1997; 414:277-80.
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Sheikh S, Ni L, Weiner H. Mutation of the conserved amino acids of mitochondria aldehyde dehydrogenase. Role of the conserved residues in the mechanism of reaction. Adv Exp Med Biol. 1997; 414:195-200.
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Weiner HL. Oral tolerance for the treatment of autoimmune diseases. Annu Rev Med. 1997; 48:341-51.
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Xiao Q, Weiner H, Crabb D. Studies on the dominant negative effect of the ALDH2*2 allele. Adv Exp Med Biol. 1997; 414:187-94.
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Fowler E, Weiner HL. Oral tolerance: elucidation of mechanisms and application to treatment of autoimmune diseases. Biopolymers. 1997; 43(4):323-35.
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Weiner H, Sheikh S, Zhou J, Wang X. Subunit interactions in mammalian liver aldehyde dehydrogenases. Adv Exp Med Biol. 1997; 414:181-5.
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Liu L, Rich BE, Inobe J, Chen W, Weiner HL. A potential pathway of Th2 development during primary immune response. IL-10 pretreated dendritic cells can prime naive CD4+ T cells to secrete IL-4. Adv Exp Med Biol. 1997; 417:375-81.
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Xiao Q, Weiner H, Crabb DW. The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. J Clin Invest. 1996 Nov 1; 98(9):2027-32.
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Woo HH, Rezai AR, Knopp EA, Weiner HL, Miller DC, Kelly PJ. Contrast-enhancing progressive multifocal leukoencephalopathy: radiological and pathological correlations: case report. Neurosurgery. 1996 Nov; 39(5):1031-4; discussion 1034-5.
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Encinas JA, Weiner HL, Kuchroo VK. Inheritance of susceptibility to experimental autoimmune encephalomyelitis. J Neurosci Res. 1996 Sep 15; 45(6):655-69.
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Futterman AD, Wellisch DK, Zighelboim J, Luna-Raines M, Weiner H. Psychological and immunological reactions of family members to patients undergoing bone marrow transplantation. Psychosom Med. 1996 Sep-Oct; 58(5):472-80.
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Encinas JA, Lees MB, Sobel RA, Symonowicz C, Greer JM, Shovlin CL, Weiner HL, Seidman CE, Seidman JG, Kuchroo VK. Genetic analysis of susceptibility to experimental autoimmune encephalomyelitis in a cross between SJL/J and B10.S mice. J Immunol. 1996 Sep 1; 157(5):2186-92.
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Waltner M, Hammen PK, Weiner H. Influence of the mature portion of a precursor protein on the mitochondrial signal sequence. J Biol Chem. 1996 Aug 30; 271(35):21226-30.
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Hammen PK, Waltner M, Hahnemann B, Heard TS, Weiner H. The role of positive charges and structural segments in the presequence of rat liver aldehyde dehydrogenase in import into mitochondria. J Biol Chem. 1996 Aug 30; 271(35):21041-8.
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al-Sabbagh AM, Goad EP, Weiner HL, Nelson PA. Decreased CNS inflammation and absence of clinical exacerbation of disease after six months oral administration of bovine myelin in diseased SJL/J mice with chronic relapsing experimental autoimmune encephalomyelitis. J Neurosci Res. 1996 Aug 15; 45(4):424-9.
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Weiner HL, Kelly PJ. A novel computer-assisted volumetric stereotactic approach for resecting tumors of the posterior parahippocampal gyrus. J Neurosurg. 1996 Aug; 85(2):272-7.
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Weiner HL, Rothman M, Miller DC, Ziff EB. Pediatric brain tumors express multiple receptor tyrosine kinases including novel cell adhesion kinases. Pediatr Neurosurg. 1996 Aug; 25(2):64-71; discussion 71-2.
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al-Sabbagh A, Nelson PA, Akselband Y, Sobel RA, Weiner HL. Antigen-driven peripheral immune tolerance: suppression of experimental autoimmmune encephalomyelitis and collagen-induced arthritis by aerosol administration of myelin basic protein or type II collagen. Cell Immunol. 1996 Jul 10; 171(1):111-9.
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Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Induction of circulating myelin basic protein and proteolipid protein-specific transforming growth factor-beta1-secreting Th3 T cells by oral administration of myelin in multiple sclerosis patients. J Clin Invest. 1996 Jul 1; 98(1):70-7.
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Olek MJ, Hohol MJ, Weiner HL. Methotrexate in the treatment of multiple sclerosis. Ann Neurol. 1996 May; 39(5):684.
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Melamed D, Fishman-Lovell J, Uni Z, Weiner HL, Friedman A. Peripheral tolerance of Th2 lymphocytes induced by continuous feeding of ovalbumin. Int Immunol. 1996 May; 8(5):717-24.
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Hohol MJ, Khoury SJ, Cook SL, Orav EJ, Hafler DA, Weiner HL. Three-year open protocol continuation study of oral tolerization with myelin antigens in multiple sclerosis and design of a phase III pivotal trial. Ann N Y Acad Sci. 1996 Feb 13; 778:243-50.
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Nussenblatt RB, Whitcup SM, de Smet MD, Caspi RR, Kozhich AT, Weiner HL, Vistica B, Gery I. Intraocular inflammatory disease (uveitis) and the use of oral tolerance: a status report. Ann N Y Acad Sci. 1996 Feb 13; 778:325-37.
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Weiner HL, Mayer LF. Oral tolerance: mechanisms and applications. Introduction. Ann N Y Acad Sci. 1996 Feb 13; 778:xiii-xviii.
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Chen YH, Weiner HL. Dose-dependent activation and deletion of antigen-specific T cells following oral tolerance. Ann N Y Acad Sci. 1996 Feb 13; 778:111-21.
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Inobe JI, Chen Y, Weiner HL. In vivo administration of IL-4 induces TGF-beta-producing cells and protects animals from experimental autoimmune encephalomyelitis. Ann N Y Acad Sci. 1996 Feb 13; 778:390-2.
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Fukaura H, Kent SC, Pietrusewicz MJ, Khoury SJ, Weiner HL, Hafler DA. Antigen-specific TGF-beta1 secretion with bovine myelin oral tolerization in multiple sclerosis. Ann N Y Acad Sci. 1996 Feb 13; 778:251-7.
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Akselband Y, Hoffer TL, Nelson PA, Gonnella PA, Weiner HL. Local and systemic immune responses in SJL/J mice during prolonged oral myelin basic protein administration. Ann N Y Acad Sci. 1996 Feb 13; 778:358-61.
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Mordes JP, Schirf B, Roipko D, Greiner DL, Weiner H, Nelson P, Rossini AA. Oral insulin does not prevent insulin-dependent diabetes mellitus in BB rats. Ann N Y Acad Sci. 1996 Feb 13; 778:418-21.
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Sayegh MH, Khoury SJ, Hancock WW, Weiner HL, Carpenter CB. Mechanisms of oral tolerance by MHC peptides. Ann N Y Acad Sci. 1996 Feb 13; 778:338-45.
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Nelson PA, Akselband Y, Dearborn SM, Al-Sabbagh A, Tian ZJ, Gonnella PA, Zamvil SS, Chen Y, Weiner HL. Effect of oral beta interferon on subsequent immune responsiveness. Ann N Y Acad Sci. 1996 Feb 13; 778:145-55.
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Matsui M, Hafler DA, Weiner HL. Pilot study of oral tolerance to keyhole limpet hemocyanin in humans: down-regulation of KLH-reactive precursor-cell frequency. Ann N Y Acad Sci. 1996 Feb 13; 778:398-404.
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Maron R, Blogg NS, Polanski M, Hancock W, Weiner HL. Oral tolerance to insulin and the insulin B-chain: cell lines and cytokine patterns. Ann N Y Acad Sci. 1996 Feb 13; 778:346-57.
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Chen Y, Inobe J, Kuchroo VK, Baron JL, Janeway CA, Weiner HL. Oral tolerance in myelin basic protein T-cell receptor transgenic mice: suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells. Proc Natl Acad Sci U S A. 1996 Jan 9; 93(1):388-91.
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Windhagen A, Nicholson LB, Weiner HL, Kuchroo VK, Hafler DA. Role of Th1 and Th2 cells in neurologic disorders. Chem Immunol. 1996; 63:171-86.
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Waltner M, Weiner H. Conversion of a nonprocessed mitochondrial precursor protein into one that is processed by the mitochondrial processing peptidase. J Biol Chem. 1995 Nov 3; 270(44):26311-7.
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Kemeny ME, Weiner H, Duran R, Taylor SE, Visscher B, Fahey JL. Immune system changes after the death of a partner in HIV-positive gay men. Psychosom Med. 1995 Nov-Dec; 57(6):547-54.
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Weiner HL, Constantini S, Cohen H, Wisoff JH. Current treatment of normal-pressure hydrocephalus: comparison of flow-regulated and differential-pressure shunt valves. Neurosurgery. 1995 Nov; 37(5):877-84.
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Hancock WW, Polanski M, Zhang J, Blogg N, Weiner HL. Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E. Am J Pathol. 1995 Nov; 147(5):1193-9.
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Xiao Q, Weiner H, Johnston T, Crabb DW. The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells. J Clin Invest. 1995 Nov; 96(5):2180-6.
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Beutel M, Deckardt R, von Rad M, Weiner H. Grief and depression after miscarriage: their separation, antecedents, and course. Psychosom Med. 1995 Nov-Dec; 57(6):517-26.
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Weiner HL. Oral tolerance: mobilizing the gut. Hosp Pract (Minneap). 1995 Sep 15; 30(9):53-8.
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Khoury SJ, Gallon L, Chen W, Betres K, Russell ME, Hancock WW, Carpenter CB, Sayegh MH, Weiner HL. Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo. J Exp Med. 1995 Aug 1; 182(2):357-66.
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Yoshino S, Quattrocchi E, Weiner HL. Suppression of antigen-induced arthritis in Lewis rats by oral administration of type II collagen. Arthritis Rheum. 1995 Aug; 38(8):1092-6.
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Weiner HL. The role of growth factor receptors in central nervous system development and neoplasia. Neurosurgery. 1995 Aug; 37(2):179-93; discussion 193-4.
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Chen Y, Inobe J, Weiner HL. Induction of oral tolerance to myelin basic protein in CD8-depleted mice: both CD4+ and CD8+ cells mediate active suppression. J Immunol. 1995 Jul 15; 155(2):910-6.
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Chen Y, Inobe J, Marks R, Gonnella P, Kuchroo VK, Weiner HL. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 1995 Jul 13; 376(6536):177-80.
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Balashov KE, Khoury SJ, Hafler DA, Weiner HL. Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. J Clin Invest. 1995 Jun; 95(6):2711-9.
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Hafler DA, Weiner HL. Immunologic mechanisms and therapy in multiple sclerosis. Immunol Rev. 1995 Apr; 144:75-107.
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Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell. 1995 Mar 10; 80(5):707-18.
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Farrés J, Wang TT, Cunningham SJ, Weiner H. Investigation of the active site cysteine residue of rat liver mitochondrial aldehyde dehydrogenase by site-directed mutagenesis. Biochemistry. 1995 Feb 28; 34(8):2592-8.
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Weiner HL, Hohol MJ, Khoury SJ, Dawson DM, Hafler DA. Therapy for multiple sclerosis. Neurol Clin. 1995 Feb; 13(1):173-96.
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Hohol MJ, Orav EJ, Weiner HL. Disease steps in multiple sclerosis: a simple approach to evaluate disease progression. Neurology. 1995 Feb; 45(2):251-5.
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Weiner HL, Miller A, Khoury SJ, Zhang ZJ, al-Sabbagh A, Brod SA, Lider O, Higgins P, Sobel R, Matsui M, et al. Treatment of autoimmune diseases by oral tolerance to autoantigens. Adv Exp Med Biol. 1995; 371B:1217-23.
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Hafler DA, Weiner HL. Antigen-specific therapies for the treatment of autoimmune diseases. Springer Semin Immunopathol. 1995; 17(1):61-76.
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Prabhu Das MR, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, Kuchroo VK. Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation. Eur J Immunol. 1995 Jan; 25(1):207-11.
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Hafler DA, Weiner HL. Antigen-specific immunosuppression: oral tolerance for the treatment of autoimmune disease. Chem Immunol. 1995; 60:126-49.
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Lee M, Leahu D, Weiner HL, Abbott R, Wisoff JH, Epstein FJ. Complications of fourth-ventricular shunts. Pediatr Neurosurg. 1995; 22(6):309-13; discussion 314.
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Weiner H, Farrés J, Rout UJ, Wang X, Zheng CF. Site directed mutagenesis to probe for active site components of liver mitochondrial aldehyde dehydrogenase. Adv Exp Med Biol. 1995; 372:1-7.
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Hafler DA, Weiner HL. Antigen specific therapies for the treatment of autoimmune diseases. Agents Actions Suppl. 1995; 47:59-77.
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Ridgway WM, Weiner HL, Fathman CG. Regulation of autoimmune response. Curr Opin Immunol. 1994 Dec; 6(6):946-55.
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Weiner HL, Wisoff JH, Rosenberg ME, Kupersmith MJ, Cohen H, Zagzag D, Shiminski-Maher T, Flamm ES, Epstein FJ, Miller DC. Craniopharyngiomas: a clinicopathological analysis of factors predictive of recurrence and functional outcome. Neurosurgery. 1994 Dec; 35(6):1001-10; discussion 1010-1.
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Weiner HL. Oral tolerance. Proc Natl Acad Sci U S A. 1994 Nov 8; 91(23):10762-5.
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Khoury SJ, Guttmann CR, Orav EJ, Hohol MJ, Ahn SS, Hsu L, Kikinis R, Mackin GA, Jolesz FA, Weiner HL. Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden. Neurology. 1994 Nov; 44(11):2120-4.
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Wang Y, Weiner H. Evaluation of electrostatic and hydrophobic effects on the interaction of mitochondrial signal sequences with phospholipid bilayers. Biochemistry. 1994 Nov 1; 33(43):12860-7.
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Fishman-Lobell J, Friedman A, Weiner HL. Different kinetic patterns of cytokine gene expression in vivo in orally tolerant mice. Eur J Immunol. 1994 Nov; 24(11):2720-4.
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Santos LM, al-Sabbagh A, Londono A, Weiner HL. Oral tolerance to myelin basic protein induces regulatory TGF-beta-secreting T cells in Peyer's patches of SJL mice. Cell Immunol. 1994 Sep; 157(2):439-47.
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al-Sabbagh A, Miller A, Santos LM, Weiner HL. Antigen-driven tissue-specific suppression following oral tolerance: orally administered myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalomyelitis in the SJL mouse. Eur J Immunol. 1994 Sep; 24(9):2104-9.
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Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 1994 Aug 26; 265(5176):1237-40.
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Khoury SJ, Weiner HL. Kappa light chains in spinal fluid for diagnosing multiple sclerosis. JAMA. 1994 Jul 20; 272(3):242-3.
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Friedman A, Weiner HL. Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc Natl Acad Sci U S A. 1994 Jul 5; 91(14):6688-92.
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Farrés J, Wang X, Takahashi K, Cunningham SJ, Wang TT, Weiner H. Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase. J Biol Chem. 1994 May 13; 269(19):13854-60.
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Kuchroo VK, Collins M, al-Sabbagh A, Sobel RA, Whitters MJ, Zamvil SS, Dorf ME, Hafler DA, Seidman JG, Weiner HL, et al. T cell receptor (TCR) usage determines disease susceptibility in experimental autoimmune encephalomyelitis: studies with TCR V beta 8.2 transgenic mice. J Exp Med. 1994 May 1; 179(5):1659-64.
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Perini C, Smith DH, Neutel JM, Smith MA, Henry JP, Bühler FR, Weiner H, Weber MA. A repressive coping style protecting from emotional distress in low-renin essential hypertensives. J Hypertens. 1994 May; 12(5):601-7.
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Miller A, Lider O, Abramsky O, Weiner HL. Orally administered myelin basic protein in neonates primes for immune responses and enhances experimental autoimmune encephalomyelitis in adult animals. Eur J Immunol. 1994 May; 24(5):1026-32.
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Zhang J, Markovic-Plese S, Lacet B, Raus J, Weiner HL, Hafler DA. Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. J Exp Med. 1994 Mar 1; 179(3):973-84.
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Zamvil SS, al-Sabbagh A, Nelson PA, Kaul D, Charles MS, Mitchell DJ, Steinman L, Weiner HL, Kuchroo VK. 'Lupus-prone' mice are susceptible to organ-specific autoimmune disease, experimental allergic encephalomyelitis. Pathobiology. 1994; 62(3):113-9.
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Weiner HL, Friedman A, Miller A, Khoury SJ, al-Sabbagh A, Santos L, Sayegh M, Nussenblatt RB, Trentham DE, Hafler DA. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu Rev Immunol. 1994; 12:809-37.
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Friedman A, al-Sabbagh A, Santos LM, Fishman-Lobell J, Polanski M, Das MP, Khoury SJ, Weiner HL. Oral tolerance: a biologically relevant pathway to generate peripheral tolerance against external and self antigens. Chem Immunol. 1994; 58:259-90.
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Miller A, al-Sabbagh A, Santos LM, Das MP, Weiner HL. Epitopes of myelin basic protein that trigger TGF-beta release after oral tolerization are distinct from encephalitogenic epitopes and mediate epitope-driven bystander suppression. J Immunol. 1993 Dec 15; 151(12):7307-15.
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Jafar JJ, Weiner HL. Surgery for angiographically occult cerebral aneurysms. J Neurosurg. 1993 Nov; 79(5):674-9.
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Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D, Lorenzo C, Sewell KL, Hafler DA, Weiner HL. Effects of oral administration of type II collagen on rheumatoid arthritis. Science. 1993 Sep 24; 261(5129):1727-30.
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Thornton K, Wang Y, Weiner H, Gorenstein DG. Import, processing, and two-dimensional NMR structure of a linker-deleted signal peptide of rat liver mitochondrial aldehyde dehydrogenase. J Biol Chem. 1993 Sep 15; 268(26):19906-14.
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Khoury SJ, Sayegh MH, Hancock WW, Gallon L, Carpenter CB, Weiner HL. Acquired tolerance to experimental autoimmune encephalomyelitis by intrathymic injection of myelin basic protein or its major encephalitogenic peptide. J Exp Med. 1993 Aug 1; 178(2):559-66.
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Jacobson SA, Leuchter AF, Walter DO, Weiner H. Serial quantitative EEG among elderly subjects with delirium. Biol Psychiatry. 1993 Aug 1; 34(3):135-40.
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Weiner HL, Rezai AR, Cooper PR. Sigmoid diverticular perforation in neurosurgical patients receiving high-dose corticosteroids. Neurosurgery. 1993 Jul; 33(1):40-3.
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Miller A, Zhang ZJ, Sobel RA, al-Sabbagh A, Weiner HL. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. VI. Suppression of adoptively transferred disease and differential effects of oral vs. intravenous tolerization. J Neuroimmunol. 1993 Jul; 46(1-2):73-82.
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Snow RB, Weiner H. Cervical laminectomy and foraminotomy as surgical treatment of cervical spondylosis: a follow-up study with analysis of failures. J Spinal Disord. 1993 Jun; 6(3):245-50; discussion 250-1.
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Abromson-Leeman S, Hayashi M, Martin C, Sobel R, al-Sabbagh A, Weiner H, Dorf ME. T cell responses to myelin basic protein in experimental autoimmune encephalomyelitis-resistant BALB/c mice. J Neuroimmunol. 1993 Jun; 45(1-2):89-101.
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Hancock WW, Sayegh MH, Kwok CA, Weiner HL, Carpenter CB. Oral, but not intravenous, alloantigen prevents accelerated allograft rejection by selective intragraft Th2 cell activation. Transplantation. 1993 May; 55(5):1112-8.
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Weiner HL, Mackin GA, Orav EJ, Hafler DA, Dawson DM, LaPierre Y, Herndon R, Lehrich JR, Hauser SL, Turel A, et al. Intermittent cyclophosphamide pulse therapy in progressive multiple sclerosis: final report of the Northeast Cooperative Multiple Sclerosis Treatment Group. Neurology. 1993 May; 43(5):910-8.
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Oettinger HF, al-Sabbagh A, Jingwu Z, LaSalle JM, Weiner HL, Hafler DA. Biological activity of recombinant human myelin basic protein. J Neuroimmunol. 1993 May; 44(2):157-62.
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Wang Y, Weiner H. The presequence of rat liver aldehyde dehydrogenase requires the presence of an alpha-helix at its N-terminal region which is stabilized by the helix at its C termini. J Biol Chem. 1993 Mar 5; 268(7):4759-65.
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Hafler DA, Zhang JW, LaSalle J, Donnelly C, Weiner HL, Wucherpfeffnig K. The development of antigen specific therapies for autoimmune diseases; investigations in multiple sclerosis as a paradigm for rheumatoid arthritis. Clin Exp Rheumatol. 1993 Mar-Apr; 11 Suppl 8:S39-40.
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Weiner HL, Mackin GA, Matsui M, Orav EJ, Khoury SJ, Dawson DM, Hafler DA. Double-blind pilot trial of oral tolerization with myelin antigens in multiple sclerosis. Science. 1993 Feb 26; 259(5099):1321-4.
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Sayegh MH, Khoury SJ, Hancock WW, Weiner HL, Carpenter CB. Induction of immunity and oral tolerance to alloantigen by polymorphic class II major histocompatibility complex allopeptides in the rat. Transplant Proc. 1993 Feb; 25(1 Pt 1):357-8.
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Zheng CF, Weiner H. Attempts to increase the expression of rat liver mitochondrial aldehyde dehydrogenase in E. coli by altering the mRNA. Adv Exp Med Biol. 1993; 328:73-9.
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Weiner HL. Treatment of autoimmune diseases by oral tolerance to autoantigens. Autoimmunity. 1993; 15 Suppl:6-7.
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Weiner HL, Zagzag D, Babu R, Weinreb HJ, Ransohoff J. Schwannoma of the fourth ventricle presenting with hemifacial spasm. A report of two cases. J Neurooncol. 1993 Jan; 15(1):37-43.
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Hurley TD, Yang Z, Bosron WF, Weiner H. Crystallization and preliminary X-ray analysis of bovine mitochondrial aldehyde dehydrogenase and human glutathione-dependent formaldehyde dehydrogenase. Adv Exp Med Biol. 1993; 328:245-50.
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Ghenbot G, Weiner H. Purification of liver aldehyde dehydrogenase by p-hydroxyacetophenone-sepharose affinity matrix and the coelution of chloramphenicol acetyl transferase from the same matrix with recombinantly expressed aldehyde dehydrogenase. Protein Expr Purif. 1992 Dec; 3(6):470-8.
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Khoury SJ, Hancock WW, Weiner HL. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J Exp Med. 1992 Nov 1; 176(5):1355-64.
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Sayegh MH, Khoury SJ, Hancock WW, Weiner HL, Carpenter CB. Induction of immunity and oral tolerance with polymorphic class II major histocompatibility complex allopeptides in the rat. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7762-6.
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Miller A, Lider O, al-Sabbagh A, Weiner HL. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. V. Hierarchy of suppression by myelin basic protein from different species. J Neuroimmunol. 1992 Aug; 39(3):243-50.
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Miller A, Weiner HL, Abramsky O. [The trimolecular complex as a target for specific immunotherapy in experimental autoimmune encephalomyelitis--applications for multiple sclerosis and other human autoimmune disease]. Harefuah. 1992 Aug; 123(3-4):110-5.
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Chiappelli F, Gormley GJ, Gwirstman HE, Lowy MT, Nguyen LD, Nguyen L, Esmail I, Strober M, Weiner H. Effects of intravenous and oral dexamethasone on selected lymphocyte subpopulations in normal subjects. Psychoneuroendocrinology. 1992 May-Jul; 17(2-3):145-52.
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Hafler DA, Cohen I, Benjamin DS, Weiner HL. T cell vaccination in multiple sclerosis: a preliminary report. Clin Immunol Immunopathol. 1992 Mar; 62(3):307-13.
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Hancock WW, Sayegh MH, Zhang ZJ, Kwok CA, Weiner HL, Carpenter CB. Oral immunization with allogeneic splenocytes inhibits development of accelerated but not acute rejection of cardiac grafts: analysis of intragraft effector mechanisms. Transplant Proc. 1992 Feb; 24(1):250-1.
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Sayegh MH, Zhang ZJ, Hancock WW, Kwok CA, Carpenter CB, Weiner HL. Down-regulation of the immune response to histocompatibility antigens and prevention of sensitization by skin allografts by orally administered alloantigen. Transplantation. 1992 Jan; 53(1):163-6.
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Zhang J, Weiner HL, Hafler DA. Autoreactive T cells in multiple sclerosis. Int Rev Immunol. 1992; 9(3):183-201.
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Miller A, Lider O, Roberts AB, Sporn MB, Weiner HL. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci U S A. 1992 Jan 1; 89(1):421-5.
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Faisal M, Chiappelli F, Ahmed II, Cooper EL, Weiner H. [The role of endogenous opioids in modulation of immunosuppression in fish]. Schriftenr Ver Wasser Boden Lufthyg. 1992; 89:785-99.
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Hafler DA, Matsui M, Wucherpfennig KW, Ota K, Weiner HL. The potential of restricted T cell recognition of myelin basic protein epitopes in the therapy of multiple sclerosis. Ann N Y Acad Sci. 1991 Dec 30; 636:251-65.
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Weiner HL, Zhang ZJ, Khoury SJ, Miller A, al-Sabbagh A, Brod SA, Lider O, Higgins P, Sobel R, Nussenblatt RB, et al. Antigen-driven peripheral immune tolerance. Suppression of organ-specific autoimmune diseases by oral administration of autoantigens. Ann N Y Acad Sci. 1991 Dec 30; 636:227-32.
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Miller A, Hafler DA, Weiner HL. Immunotherapy in autoimmune diseases. Curr Opin Immunol. 1991 Dec; 3(6):936-40.
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Zhang ZJ, Davidson L, Eisenbarth G, Weiner HL. Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci U S A. 1991 Nov 15; 88(22):10252-6.
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Miller A, Lider O, Weiner HL. Antigen-driven bystander suppression after oral administration of antigens. J Exp Med. 1991 Oct 1; 174(4):791-8.
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Carr LG, Mellencamp RJ, Crabb DW, Weiner H, Lumeng L, Li TK. Polymorphism of the rat liver mitochondrial aldehyde dehydrogenase cDNA. Alcohol Clin Exp Res. 1991 Oct; 15(5):753-6.
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Jeng JJ, Weiner H. Purification and characterization of catalytically active precursor of rat liver mitochondrial aldehyde dehydrogenase expressed in Escherichia coli. Arch Biochem Biophys. 1991 Sep; 289(2):214-22.
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Lider O, Miller A, Miron S, Hershkoviz R, Weiner HL, Zhang XM, Heber-Katz E. Nonencephalitogenic CD4-CD8- V alpha 2V beta 8.2+ anti-myelin basic protein rat T lymphocytes inhibit disease induction. J Immunol. 1991 Aug 15; 147(4):1208-13.
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Wucherpfennig KW, Weiner HL, Hafler DA. T-cell recognition of myelin basic protein. Immunol Today. 1991 Aug; 12(8):277-82.
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Miller A, Hafler DA, Weiner HL. Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases. FASEB J. 1991 Aug; 5(11):2560-6.
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Heymann-Mönnikes I, Taché Y, Trauner M, Weiner H, Garrick T. CRF microinjected into the dorsal vagal complex inhibits TRH analog- and kainic acid-stimulated gastric contractility in rats. Brain Res. 1991 Jul 19; 554(1-2):139-44.
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Weiner HL. New diagnostic modalities for the evaluation of the patient with syncope. Del Med J. 1991 Jul; 63(7):407-10.
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Brod SA, al-Sabbagh A, Sobel RA, Hafler DA, Weiner HL. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin antigens: IV. Suppression of chronic relapsing disease in the Lewis rat and strain 13 guinea pig. Ann Neurol. 1991 Jun; 29(6):615-22.
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Hafler DA, Orav J, Gertz R, Stazzone L, Weiner HL. Immunologic effects of cyclophosphamide/ACTH in patients with chronic progressive multiple sclerosis. J Neuroimmunol. 1991 May; 32(2):149-58.
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Weiner HL, McCarthy EA, Pritchett EL. Regular ventricular rhythms in patients with symptomatic paroxysmal atrial fibrillation. J Am Coll Cardiol. 1991 May; 17(6):1283-7.
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Zamaroczy D, Schluesener HJ, Jolesz FA, Sobel RA, Colucci VM, Weiner HL, Sandor T. Differentiation of experimental white matter lesions using multiparametric magnetic resonance measurements. Invest Radiol. 1991 Apr; 26(4):317-24.
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Weiner H. Stressful experience and cardiorespiratory disorders. Circulation. 1991 Apr; 83(4 Suppl):II2-8.
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Wang TT, Wang Y, Weiner H. Effects of protein size on the rate of import of the precursors of aldehyde dehydrogenase and ornithine transcarbamylase into rat liver mitochondria. Alcohol Clin Exp Res. 1991 Mar; 15(2):286-90.
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Thurau SR, Caspi RR, Chan CC, Weiner HL, Nussenblatt RB. [Immunologic suppression of experimental autoimmune uveitis]. Fortschr Ophthalmol. 1991; 88(4):404-7.
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Lee SJ, Wucherpfennig KW, Brod SA, Benjamin D, Weiner HL, Hafler DA. Common T-cell receptor V beta usage in oligoclonal T lymphocytes derived from cerebrospinal fluid and blood of patients with multiple sclerosis. Ann Neurol. 1991 Jan; 29(1):33-40.
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Hafler DA, Chofflon M, Kurt-Jones E, Weiner HL. Interleukin-1 corrects the defective autologous mixed lymphocyte response in multiple sclerosis. Clin Immunol Immunopathol. 1991 Jan; 58(1):115-25.
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Weiner H, Farrés J, Wang TT, Cunningham SJ, Zheng CF, Ghenbot G. Probing the active site of aldehyde dehydrogenase by site directed mutagenesis. Adv Exp Med Biol. 1991; 284:13-7.
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Toms R, Weiner HL, Johnson D. Identification of IgE-positive cells and mast cells in frozen sections of multiple sclerosis brains. J Neuroimmunol. 1990 Dec; 30(2-3):169-77.
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Khoury SJ, Lider O, al-Sabbagh A, Weiner HL. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. III. Synergistic effect of lipopolysaccharide. Cell Immunol. 1990 Dec; 131(2):302-10.
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Heymann-Mönnikes I, Livingston EH, Taché Y, Sierra A, Weiner H, Garrick T. Bombesin microinjected into the dorsal vagal complex inhibits TRH-stimulated gastric contractility in rats. Brain Res. 1990 Nov 19; 533(2):309-14.
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Zhang ZY, Lee CS, Lider O, Weiner HL. Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen. J Immunol. 1990 Oct 15; 145(8):2489-93.
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Ota K, Matsui M, Milford EL, Mackin GA, Weiner HL, Hafler DA. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature. 1990 Jul 12; 346(6280):183-7.
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Wucherpfennig KW, Ota K, Endo N, Seidman JG, Rosenzweig A, Weiner HL, Hafler DA. Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein. Science. 1990 May 25; 248(4958):1016-9.
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Santos LM, Lider O, Audette J, Khoury SJ, Weiner HL. Characterization of immunomodulatory properties and accessory cell function of small intestinal epithelial cells. Cell Immunol. 1990 Apr 15; 127(1):26-34.
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Nussenblatt RB, Caspi RR, Mahdi R, Chan CC, Roberge F, Lider O, Weiner HL. Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen. J Immunol. 1990 Mar 1; 144(5):1689-95.
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Guan KL, Weiner H. Sequence of the precursor of bovine liver mitochondrial aldehyde dehydrogenase as determined from its cDNA, its gene, and its functionality. Arch Biochem Biophys. 1990 Mar; 277(2):351-60.
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Weiner HL, Dau PC, Khatri BO, Petajan J, Birnbaum G, McQuillen MP, Fosburg MT, Feldstein M, Orav J. Double-blind study of true vs. sham plasmapheresis in patients being treated with immunosuppression for acute attacks of multiple sclerosis. Prog Clin Biol Res. 1990; 337:283.
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Stephens RL, Garrick T, Weiner H, Taché Y. Endogenous serotonin produces an inhibitory tone on vagally stimulated gastric function. Ann N Y Acad Sci. 1990; 597:114-27.
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Wucherpfennig KW, Weiner HL. Immunologic mechanisms in chronic demyelinating diseases of the central and peripheral nervous system. Res Publ Assoc Res Nerv Ment Dis. 1990; 68:105-16.
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Seeldrayers PA, Yasui D, Weiner HL, Johnson D. Treatment of experimental allergic neuritis with nedocromil sodium. J Neuroimmunol. 1989 Dec; 25(2-3):221-6.
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Guan KL, Weiner H. Influence of the 5'-end region of aldehyde dehydrogenase mRNA on translational efficiency. Potential secondary structure inhibition of translation in vitro. J Biol Chem. 1989 Oct 25; 264(30):17764-9.
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Chofflon M, González V, Weiner HL, Hafler DA. Inflammatory cerebrospinal fluid T cells have activation requirements characteristic of CD4+CD45RA- T cells. Eur J Immunol. 1989 Oct; 19(10):1791-5.
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Faisal M, Chiappelli F, Ahmed II, Cooper EL, Weiner H. Social confrontation "stress" in aggressive fish is associated with an endogenous opioid-mediated suppression of proliferative response to mitogens and nonspecific cytotoxicity. Brain Behav Immun. 1989 Sep; 3(3):223-33.
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Weiner HL, Dau PC, Khatri BO, Petajan JH, Birnbaum G, McQuillen MP, Fosburg MT, Feldstein M, Orav EJ. Double-blind study of true vs. sham plasma exchange in patients treated with immunosuppression for acute attacks of multiple sclerosis. Neurology. 1989 Sep; 39(9):1143-9.
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Weiner HL, Paty DW. Diagnostic and therapeutic trials in multiple sclerosis: a new look. Summary of Jekyll Island workshop. Neurology. 1989 Jul; 39(7):972-6.
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Chofflon M, Weiner HL, Morimoto C, Hafler DA. Decrease of suppressor inducer (CD4+2H4+) T cells in multiple sclerosis cerebrospinal fluid. Ann Neurol. 1989 May; 25(5):494-9.
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Weiner HL, Swain JL. Acidic fibroblast growth factor mRNA is expressed by cardiac myocytes in culture and the protein is localized to the extracellular matrix. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2683-7.
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Hafler DA, Weiner HL. MS: a CNS and systemic autoimmune disease. Immunol Today. 1989 Mar; 10(3):104-7.
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Farrés J, Guan KL, Weiner H. Primary structures of rat and bovine liver mitochondrial aldehyde dehydrogenases deduced from cDNA sequences. Eur J Biochem. 1989 Mar 1; 180(1):67-74.
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Duby AD, Weiner HL, Benjamin DS, Seidman JG, Hafler DA. Sequestration of virus-specific T cells in the cerebrospinal fluid of a patient with varicella zoster viral meningoencephalitis. J Neuroimmunol. 1989 Mar; 22(1):63-8.
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Yirmiya R, Shavit Y, Ben-Eliyahu S, Martin FC, Weiner H, Liebeskind JC. Natural killer cell activity in vasopressin-deficient rats (Brattleboro strain). Brain Res. 1989 Feb 6; 479(1):16-22.
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Hauser SL, Fleischnick E, Weiner HL, Marcus D, Awdeh Z, Yunis EJ, Alper CA. Extended major histocompatibility complex haplotypes in patients with multiple sclerosis. Neurology. 1989 Feb; 39(2 Pt 1):275-7.
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Lider O, Santos LM, Lee CS, Higgins PJ, Weiner HL. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein. II. Suppression of disease and in vitro immune responses is mediated by antigen-specific CD8+ T lymphocytes. J Immunol. 1989 Feb 1; 142(3):748-52.
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Hafler DA, Brod SA, Weiner HL. Immunoregulation in multiple sclerosis. Res Immunol. 1989 Feb; 140(2):233-9; discussion 245-8.
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Weiner H, Wang TT, Farrés J, Jeng JJ. Precursors and post translational modification of mitochondrial aldehyde dehydrogenase. Prog Clin Biol Res. 1989; 290:81-92.
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Cohen IR, Weiner HL. T-cell vaccination. Immunol Today. 1988 Nov; 9(11):332-5.
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Shepley MP, Sherry B, Weiner HL. Monoclonal antibody identification of a 100-kDa membrane protein in HeLa cells and human spinal cord involved in poliovirus attachment. Proc Natl Acad Sci U S A. 1988 Oct; 85(20):7743-7.
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Chofflon M, Weiner HL, Morimoto C, Hafler DA. Loss of functional suppression is linked to decreases in circulating suppressor inducer (CD4+ 2H4+) T cells in multiple sclerosis. Ann Neurol. 1988 Aug; 24(2):185-91.
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Hafler DA, Weiner HL. Immunosuppression with monoclonal antibodies in multiple sclerosis. Neurology. 1988 Jul; 38(7 Suppl 2):42-7.
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Hafler DA, Ritz J, Schlossman SF, Weiner HL. Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses. J Immunol. 1988 Jul 1; 141(1):131-8.
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Carter JL, Hafler DA, Dawson DM, Orav J, Weiner HL. Immunosuppression with high-dose i.v. cyclophosphamide and ACTH in progressive multiple sclerosis: cumulative 6-year experience in 164 patients. Neurology. 1988 Jul; 38(7 Suppl 2):9-14.
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Schluesener HJ, Sobel RA, Weiner HL. Demyelinating experimental allergic encephalomyelitis (EAE) in the rat: treatment with a monoclonal antibody against activated T cells. J Neuroimmunol. 1988 Jul; 18(4):341-51.
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Irwin M, Daniels M, Risch SC, Bloom E, Weiner H. Plasma cortisol and natural killer cell activity during bereavement. Biol Psychiatry. 1988 Jun; 24(2):173-8.
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Garrick T, Veiseh A, Sierra A, Weiner H, Taché Y. Corticotropin-releasing factor acts centrally to suppress stimulated gastric contractility in the rat. Regul Pept. 1988 May; 21(1-2):173-81.
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Hafler DA, Duby AD, Lee SJ, Benjamin D, Seidman JG, Weiner HL. Oligoclonal T lymphocytes in the cerebrospinal fluid of patients with multiple sclerosis. J Exp Med. 1988 Apr 1; 167(4):1313-22.
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Sobel RA, Hafler DA, Castro EE, Morimoto C, Weiner HL. The 2H4 (CD45R) antigen is selectively decreased in multiple sclerosis lesions. J Immunol. 1988 Apr 1; 140(7):2210-4.
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Johnson D, Seeldrayers PA, Weiner HL. The role of mast cells in demyelination. 1. Myelin proteins are degraded by mast cell proteases and myelin basic protein and P2 can stimulate mast cell degranulation. Brain Res. 1988 Mar 15; 444(1):195-8.
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Weiner HL, Hafler DA. Immunotherapy of multiple sclerosis. Ann Neurol. 1988 Mar; 23(3):211-22.
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Farrés J, Guan KL, Weiner H. Sequence of the signal peptide for rat liver mitochondrial aldehyde dehydrogenase. Biochem Biophys Res Commun. 1988 Feb 15; 150(3):1083-7.
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Higgins PJ, Weiner HL. Suppression of experimental autoimmune encephalomyelitis by oral administration of myelin basic protein and its fragments. J Immunol. 1988 Jan 15; 140(2):440-5.
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Carter JL, Dawson DM, Hafler DA, Fallis RJ, Stazzone L, Orav J, Weiner HL. Cumulative experience with high-dose intravenous cyclophosphamide and ACTH therapy in chronic progressive multiple sclerosis. Ann N Y Acad Sci. 1988; 540:535-6.
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Sobel RA, Hafler DA, Castro EE, Morimoto C, Weiner HL. Immunohistochemical analysis of suppressor-inducer and helper-inducer T cells in multiple sclerosis brain tissue. Ann N Y Acad Sci. 1988; 540:306-8.
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Schluesener HJ, Wucherpfennig KW, Weiner HL. Gene activation during experimental allergic encephalomyelitis. Cloning of new cDNAs. Ann N Y Acad Sci. 1988; 540:264-5.
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Hafler DA, Weiner HL. Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human antimouse responses. Ann N Y Acad Sci. 1988; 540:557-9.
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Chofflon M, Weiner HL, Hafler DA. Loss of functional suppression is linked to decreases in circulating suppressor-inducer (CD4+ 2H4+) T cells in multiple sclerosis. Ann N Y Acad Sci. 1988; 540:330-2.
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Johnson D, Weiner HL, Seeldrayers PA. Role of mast cells in peripheral nervous system demyelination. Ann N Y Acad Sci. 1988; 540:727-8.
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Schluesener HJ, Sobel RA, Linington C, Weiner HL. A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J Immunol. 1987 Dec 15; 139(12):4016-21.
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Hafler DA, Weiner HL. T cells in multiple sclerosis and inflammatory central nervous system diseases. Immunol Rev. 1987 Dec; 100:307-32.
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Hauser SL, Che M, Fallis RJ, Weiner HL. Immunoregulatory abnormalities induced by experimental reovirus infection: functional alterations in T-cell subpopulations. Clin Immunol Immunopathol. 1987 Dec; 45(3):481-90.
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Gitlin MJ, Weiner H, Fairbanks L, Hershman JM, Friedfeld N. Failure of T3 to potentiate tricyclic antidepressant response. J Affect Disord. 1987 Nov-Dec; 13(3):267-72.
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Hafler DA, Fox DA, Benjamin D, Blue ML, Weiner HL. Secondary immune amplification following live poliovirus immunization in humans. Clin Immunol Immunopathol. 1987 Sep; 44(3):321-8.
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Weiner HL. Cop 1 therapy for multiple sclerosis. N Engl J Med. 1987 Aug 13; 317(7):442-4.
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Weiner HL, Weiner LH, Swain JL. Tissue distribution and developmental expression of the messenger RNA encoding angiogenin. Science. 1987 Jul 17; 237(4812):280-2.
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Hafler DA, Weiner HL. In vivo labeling of blood T cells: rapid traffic into cerebrospinal fluid in multiple sclerosis. Ann Neurol. 1987 Jul; 22(1):89-93.
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Hafler DA, Benjamin DS, Burks J, Weiner HL. Myelin basic protein and proteolipid protein reactivity of brain- and cerebrospinal fluid-derived T cell clones in multiple sclerosis and postinfectious encephalomyelitis. J Immunol. 1987 Jul 1; 139(1):68-72.
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Irwin M, Daniels M, Bloom ET, Smith TL, Weiner H. Life events, depressive symptoms, and immune function. Am J Psychiatry. 1987 Apr; 144(4):437-41.
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Fallis RJ, Powers ML, Weiner HL. Serial analysis of peripheral blood T-cell phenotypes and myelin basic protein reactivity in experimental allergic encephalomyelitis. Neurology. 1987 Apr; 37(4):719-23.
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Fallis RJ, Powers ML, Sy MS, Weiner HL. Adoptive transfer of murine chronic-relapsing autoimmune encephalomyelitis. Analysis of basic protein-reactive cells in lymphoid organs and nervous system of donor and recipient animals. J Neuroimmunol. 1987 Mar; 14(2):205-19.
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Dawson DM, Carter JL, Hafler DA, Weiner HL. Immunosuppression in progressive multiple sclerosis with high dose intravenous cyclophosphamide and monoclonal antibodies. Riv Neurol. 1987 Mar-Apr; 57(2):88-91.
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Irwin M, Daniels M, Smith TL, Bloom E, Weiner H. Impaired natural killer cell activity during bereavement. Brain Behav Immun. 1987 Mar; 1(1):98-104.
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Morimoto C, Hafler DA, Weiner HL, Letvin NL, Hagan M, Daley J, Schlossman SF. Selective loss of the suppressor-inducer T-cell subset in progressive multiple sclerosis. Analysis with anti-2H4 monoclonal antibody. N Engl J Med. 1987 Jan 8; 316(2):67-72.
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Guan K, Weiner H. Molecular biology studies of beef liver aldehyde dehydrogenase. Prog Clin Biol Res. 1987; 232:15-24.
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Tu GC, Weiner H. Aldehyde dehydrogenase: a multi-functional enzyme. Prog Clin Biol Res. 1987; 232:67-75.
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Brown RH, Johnson D, Ogonowski M, Weiner HL. Type 1 human poliovirus binds to human synaptosomes. Ann Neurol. 1987 Jan; 21(1):64-70.
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Weiner H. Subcellular localization of acetaldehyde oxidation in liver. Ann N Y Acad Sci. 1987; 492:25-34.
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Brown RH, Johnson D, Ogonowski M, Weiner HL. Antineural antibodies in the serum of patients with amyotrophic lateral sclerosis. Neurology. 1987 Jan; 37(1):152-5.
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Weiner H, McMichael M, Lindahl-Hellstrom E, Tu GC. Use of polyclonal antibodies to study properties of mammalian aldehyde dehydrogenases. Alcohol Alcohol Suppl. 1987; 1:187-91.
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Johnson D, Hafler DA, Fallis RJ, Lees MB, Brady RO, Quarles RH, Weiner HL. Cell-mediated immunity to myelin-associated glycoprotein, proteolipid protein, and myelin basic protein in multiple sclerosis. J Neuroimmunol. 1986 Nov; 13(1):99-108.
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Hafler DA, Fox DA, Benjamin D, Weiner HL. Antigen reactive memory T cells are defined by Ta1. J Immunol. 1986 Jul 15; 137(2):414-8.
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Hauser SL, Bhan AK, Gilles F, Kemp M, Kerr C, Weiner HL. Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions. Ann Neurol. 1986 Jun; 19(6):578-87.
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Dichter MA, Weiner HL, Fields BN, Mitchell G, Noseworthy J, Gaulton G, Greene M. Antiidiotypic antibody to reovirus binds to neurons and protects from viral infection. Ann Neurol. 1986 Jun; 19(6):555-8.
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Hafler DA, Fallis RJ, Dawson DM, Schlossman SF, Reinherz EL, Weiner HL. Immunologic responses of progressive multiple sclerosis patients treated with an anti-T-cell monoclonal antibody, anti-T12. Neurology. 1986 Jun; 36(6):777-84.
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Brown RH, Hauser SL, Harrington H, Weiner HL. Failure of immunosuppression with a ten- to 14-day course of high-dose intravenous cyclophosphamide to alter the progression of amyotrophic lateral sclerosis. Arch Neurol. 1986 Apr; 43(4):383-4.
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Hafler DA, Johnson D, Kelly JJ, Panitch H, Kyle R, Weiner HL. Monoclonal gammopathy and neuropathy: myelin-associated glycoprotein reactivity and clinical characteristics. Neurology. 1986 Jan; 36(1):75-8.
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Irwin M, Daniels M, Bloom ET, Weiner H. Life events, depression, and natural killer cell activity. Psychopharmacol Bull. 1986; 22(4):1093-6.
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Levin LA, Weiner HL. Antigen presentation by astrocytes--a commentary. J Mol Cell Immunol. 1986; 2(5):281-2.
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Weiner H. [Central nervous system control mechanisms and the development of disease--their significance for psychosomatic medicine]. Psychother Psychosom Med Psychol. 1985 Dec; 35(12):310-4.
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Hauser SL, Ault KA, Johnson D, Hoban C, Weiner HL. Increased IgG secretion by unstimulated mononuclear cells in active multiple sclerosis and functional assessment of the T8 subset. Clin Immunol Immunopathol. 1985 Dec; 37(3):312-23.
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Hafler DA, Hemler ME, Christenson L, Williams JM, Shapiro HM, Strom TB, Strominger JL, Weiner HL. Investigation of in vivo activated T cells in multiple sclerosis and inflammatory central nervous system diseases. Clin Immunol Immunopathol. 1985 Nov; 37(2):163-71.
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Hafler DA, Buchsbaum M, Johnson D, Weiner HL. Phenotypic and functional analysis of T cells cloned directly from the blood and cerebrospinal fluid of patients with multiple sclerosis. Ann Neurol. 1985 Oct; 18(4):451-8.
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Hafler DA, Buchsbaum M, Weiner HL. Decreased autologous mixed lymphocyte reaction in multiple sclerosis. J Neuroimmunol. 1985 Oct; 9(6):339-47.
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Hafler DA, Fox DA, Manning ME, Schlossman SF, Reinherz EL, Weiner HL. In vivo activated T lymphocytes in the peripheral blood and cerebrospinal fluid of patients with multiple sclerosis. N Engl J Med. 1985 May 30; 312(22):1405-11.
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Weiner HL. An assessment of plasma exchange in progressive multiple sclerosis. Neurology. 1985 Mar; 35(3):320-2.
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Weiner H, Takahashi K. Spontaneous dissociation of tetrameric horse liver mitochondrial aldehyde dehydrogenase to dimers. Prog Clin Biol Res. 1985; 174:83-90.
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Weiner H, Lin FP, Sanny CG. Chemical probes for the active site of aldehyde dehydrogenase. Prog Clin Biol Res. 1985; 174:57-70.
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Hauser SL, Bahn AK, Che M, Gilles F, Weiner HL. Redistribution of Lyt-bearing T cells in acute murine experimental allergic encephalomyelitis: selective migration of Lyt-1 cells to the central nervous system is associated with a transient depletion of Lyt-1 cells in peripheral blood. J Immunol. 1984 Dec; 133(6):3037-42.
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Hauser SL, Weiner HL, Bhan AK, Shapiro ME, Che M, Aldrich WR, Letvin NL. Lyt-1 cells mediate acute murine experimental allergic encephalomyelitis. J Immunol. 1984 Nov; 133(5):2288-90.
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Dichter MA, Weiner HL. Infection of neuronal cell cultures with reovirus mimics in vitro patterns of neurotropism. Ann Neurol. 1984 Nov; 16(5):603-10.
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Epstein RL, Finberg R, Powers ML, Weiner HL. Interaction of reovirus with cell surface receptors. IV. The reovirus type 3 receptor is expressed predominantly on murine Lyt-2,3+ and human T8+ cells. J Immunol. 1984 Sep; 133(3):1614-7.
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Hauser SL, Fosburg M, Kevy SV, Weiner HL. Lymphocytapheresis in chronic progressive multiple sclerosis: immunologic and clinical effects. Neurology. 1984 Jul; 34(7):922-6.
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Tardieu M, Powers ML, Hafler DA, Hauser SL, Weiner HL. Autoimmunity following viral infection: demonstration of monoclonal antibodies against normal tissue following infection of mice with reovirus and demonstration of shared antigenicity between virus and lymphocytes. Eur J Immunol. 1984 Jun; 14(6):561-5.
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Weiner HL, Hafler DA, Fallis RJ, Johnson D, Ault KA, Hauser SL. Altered blood T-cell subsets in patients with multiple sclerosis. J Neuroimmunol. 1984 Apr; 6(2):115-21.
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Hauser SL, Weiner HL, Che M, Shapiro ME, Gilles F, Letvin NL. Prevention of experimental allergic encephalomyelitis (EAE) in the SJL/J mouse by whole body ultraviolet irradiation. J Immunol. 1984 Mar; 132(3):1276-81.
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Epstein RL, Powers ML, Rogart RB, Weiner HL. Binding of 125I-labeled reovirus to cell surface receptors. Virology. 1984 Feb; 133(1):46-55.
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Weiner HL, Hafler DA, Fallis RJ, Johnson D, Ault KA, Hauser SL. T cell subsets in patients with multiple sclerosis. An overview. Ann N Y Acad Sci. 1984; 436:281-93.
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Weiner HL, Hauser SL, Hafler DA, Fallis RJ, Lehrich JR, Dawson DM. The use of cyclophosphamide in the treatment of multiple sclerosis. Ann N Y Acad Sci. 1984; 436:373-81.
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Tardieu M, Noseworthy JH, Perry L, Che M, Greene MI, Weiner HL. Generation of a monoclonal antibody (Epenl) which binds selectively to murine ependymal cells. Brain Res. 1983 Oct 31; 277(2):339-46.
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Weiner HL, Ebers GC. Development of simple trial protocols. Arch Neurol. 1983 Oct 21; 40(11):700.
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Weiner HL, Ellison GW. A working protocol to be used as a guideline for trials in multiple sclerosis. Arch Neurol. 1983 Oct 21; 40(11):704-10.
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Weiner HL, Dau P, Birnbaum G, Feldstein M, Khatri B, Petajan J, McQuillen MP. Plasma exchange in acute multiple sclerosis. Design of a cooperative study. Arch Neurol. 1983 Oct 21; 40(11):691-2.
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Hauser SL, Dawson DM, Lehrich JR, Beal MF, Kevy SV, Weiner HL. Immunosuppression and plasmapheresis in chronic progressive multiple sclerosis. Design of a clinical trial. Arch Neurol. 1983 Oct 21; 40(11):687-90.
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Hauser SL, Bhan AK, Gilles FH, Hoban CJ, Reinherz EL, Schlossman SF, Weiner HL. Immunohistochemical staining of human brain with monoclonal antibodies that identify lymphocytes, monocytes, and the Ia antigen. J Neuroimmunol. 1983 Oct; 5(2):197-205.
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Bertino JR, Carman MD, Weiner HL, Cashmore A, Moroson BA, Srimatkandada S, Schornagel JH, Medina WD, Dube SK. Gene amplification and altered enzymes as mechanisms for the development of drug resistance. Cancer Treat Rep. 1983 Oct; 67(10):901-4.
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Crary B, Hauser SL, Borysenko M, Kutz I, Hoban C, Ault KA, Weiner HL, Benson H. Epinephrine-induced changes in the distribution of lymphocyte subsets in peripheral blood of humans. J Immunol. 1983 Sep; 131(3):1178-81.
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Tardieu M, Powers ML, Weiner HL. Age dependent susceptibility to Reovirus type 3 encephalitis: role of viral and host factors. Ann Neurol. 1983 Jun; 13(6):602-7.
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Hauser SL, Reinherz EL, Hoban CJ, Schlossman SF, Weiner HL. CSF cells in multiple sclerosis: monoclonal antibody analysis and relationship to peripheral blood T-cell subsets. Neurology. 1983 May; 33(5):575-9.
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Hauser SL, Reinherz EL, Hoban CJ, Schlossman SF, Weiner HL. Immunoregulatory T-cells and lymphocytotoxic antibodies in active multiple sclerosis: weekly analysis over a six-month period. Ann Neurol. 1983 Apr; 13(4):418-25.
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Hauser SL, Dawson DM, Lehrich JR, Beal MF, Kevy SV, Propper RD, Mills JA, Weiner HL. Intensive immunosuppression in progressive multiple sclerosis. A randomized, three-arm study of high-dose intravenous cyclophosphamide, plasma exchange, and ACTH. N Engl J Med. 1983 Jan 27; 308(4):173-80.
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Weiner H, Takahashi K. Effects of magnesium and calcium on mitochondrial and cytosolic liver aldehyde dehydrogenases. Pharmacol Biochem Behav. 1983; 18 Suppl 1:109-12.
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Weiner HL, Hauser SL. Immunoregulation in multiple sclerosis. Prog Brain Res. 1983; 59:339-43.
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Weiner HL, Tardieu M, Epstein RL, Fontana A, Powers ML. Viral interactions with receptors in the central nervous system and on lymphocytes. Prog Brain Res. 1983; 59:23-7.
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Weiner H. Stress and ulcers-the continuing association. Gastroenterology. 1983 Jan; 84(1):189-90.
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Weiner HL, Hauser SL. Neuroimmunology. II: Antigenic specificity of the nervous system. Ann Neurol. 1982 Dec; 12(6):499-509.
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Hauser SL, Ropper AH, Perlo VP, Reinherz EL, Schlossman SF, Weiner HL. T-cell subsets in human autoimmune diseases. Neurology. 1982 Nov; 32(11):1320-1.
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Hauser SL, Bresnan MJ, Reinherz EL, Weiner HL. Childhood multiple sclerosis: clinical features and demonstration of changes in T cell subsets with disease activity. Ann Neurol. 1982 May; 11(5):463-8.
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Weiner HL, Hauser SL. Neuroimmunology I: Immunoregulation in neurological disease. Ann Neurol. 1982 May; 11(5):437-49.
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Hauser SL, Weiner HL, Ault KA. Clonally restricted B cells in peripheral blood of multiple sclerosis patients: kappa/lambda staining patterns. Ann Neurol. 1982 Apr; 11(4):408-12.
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Tardieu M, Weiner HL. Viral receptors on isolated murine and human ependymal cells. Science. 1982 Jan 22; 215(4531):419-21.
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Hauser SL, Fosburg M, Kevy S, Weiner HL. Plasmapheresis, lymphocytapheresis, and immunosuppressive drug therapy in multiple sclerosis. Prog Clin Biol Res. 1982; 106:239-54.
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Weiner H, Freytag S, Fox JM, Hu JH. Reversible inhibitors of aldehyde dehydrogenase. Prog Clin Biol Res. 1982; 114:91-102.
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Weiner H. A model to estimate the in vivo level of tetrahydroisoquinoline in brain during the consumption of ethanol. Prog Clin Biol Res. 1982; 90:69-79.
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Tardieu M, Epstein RL, Weiner HL. Interaction of viruses with cell surface receptors. Int Rev Cytol. 1982; 80:27-61.
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Nepom JT, Weiner HL, Dichter MA, Tardieu M, Spriggs DR, Gramm CF, Powers ML, Fields BN, Greene MI. Identification of a hemagglutinin-specific idiotype associated with reovirus recognition shared by lymphoid and neural cells. J Exp Med. 1982 Jan 1; 155(1):155-67.
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Nepom JT, Tardieu M, Epstein RL, Noseworthy JH, Weiner HL, Gentsch J, Fields BN, Greene MI. Virus-binding receptors: similarities to immune receptors as determined by anti-idiotypic antibodies. Surv Immunol Res. 1982; 1(3):255-61.
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Weiner H. Aldehyde dehydrogenase. Prog Clin Biol Res. 1982; 114:1-9.
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Epstein RL, Powers ML, Weiner HL. Interaction of reovirus with cell surface receptors. III. Reovirus type 3 induces capping of viral receptors on murine lymphocytes. J Immunol. 1981 Nov; 127(5):1800-3.
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Takahashi K, Weiner H, Filmer DL. Effects of pH on horse liver aldehyde dehydrogenase: alterations in metal ion activation, number of functioning active sites, and hydrolysis of the acyl intermediate. Biochemistry. 1981 Oct 13; 20(21):6225-30.
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Rubin D, Weiner HL, Fields BN, Greene MI. Immunologic tolerance after oral administration of reovirus: requirement for two viral gene products for tolerance induction. J Immunol. 1981 Oct; 127(4):1697-701.
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Hauser SL, Ault KA, Levin MJ, Garovoy MR, Weiner HL. Natural killer cell activity in multiple sclerosis. J Immunol. 1981 Sep; 127(3):1114-7.
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Takahashi K, Weiner H. Nicotinamide adenine dinucleotide activation of the esterase reaction of horse liver aldehyde dehydrogenase. Biochemistry. 1981 May 12; 20(10):2720-6.
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Finberg R, Weiner HL, Burakoff SJ, Fields BN. Type-specific reovirus antiserum blocks the cytotoxic T-cell-target cell interaction: evidence for the association of the viral hemagglutinin of a nonenveloped virus with the cell surface. Infect Immun. 1981 Feb; 31(2):646-9.
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Katz JL, Weiner H. The aberrant reproductive endocrinology of anorexia nervosa. Res Publ Assoc Res Nerv Ment Dis. 1981; 59:165-80.
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Weiner H. Brain, behavior, and bodily disease: a summary. Res Publ Assoc Res Nerv Ment Dis. 1981; 59:335-69.
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Takahashi K, Weiner H, Hu JH. Increase in the stoichiometry of the functioning active sites of horse liver aldehyde dehydrogenase in the presence of magnesium ions. Arch Biochem Biophys. 1980 Dec; 205(2):571-8.
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Fontana A, Weiner HL. Interaction of reovirus with cell surface receptors. II. Generation of suppressor T cells by the hemagglutinin of reovirus type 3. J Immunol. 1980 Dec; 125(6):2660-4.
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Weiner IH, Weiner HL. Nocturnal leg muscle cramps. JAMA. 1980 Nov 21; 244(20):2332-3.
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Weiner HL, Dawson DM. Plasmapheresis in multiple sclerosis: preliminary study. Neurology. 1980 Oct; 30(10):1029-33.
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Takahashi K, Weiner H. Magnesium stimulation of catalytic activity of horse liver aldehyde dehydrogenase. Changes in molecular weight and catalytic sites. J Biol Chem. 1980 Sep 10; 255(17):8206-9.
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Reinherz EL, Weiner HL, Hauser SL, Cohen JA, Distaso JA, Schlossman SF. Loss of suppressor T cells in active multiple sclerosis. Analysis with monoclonal antibodies. N Engl J Med. 1980 Jul 17; 303(3):125-9.
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Greene MI, Weiner HL. Delayed hypersensitivity in mice infected with reovirus. II. Induction of tolerance and suppressor T cells to viral specific gene products. J Immunol. 1980 Jul; 125(1):283-7.
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Weiner HL, Greene MI, Fields BN. Delayed hypersensitivity in mice infected with reovirus. I. Identification of host and viral gene products responsible for the immune response. J Immunol. 1980 Jul; 125(1):278-82.
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Weiner HL, Powers ML, Fields BN. Absolute linkage of virulence and central nervous system cell tropism of reoviruses to viral hemagglutinin. J Infect Dis. 1980 May; 141(5):609-16.
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Weiner HL, Ault KA, Fields BN. Interaction of reovirus with cell surface receptors. I. Murine and human lymphocytes have a receptor for the hemagglutinin of reovirus type 3. J Immunol. 1980 May; 124(5):2143-8.
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Takahashi K, Brown CS, Weiner H. Mechanism of the magnesium ion activation of the catalytic activity of horse liver aldehyde dehydrogenase. Adv Exp Med Biol. 1980; 132:181-8.
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Fields BN, Weiner HL, Drayna DT, Sharpe AH. The role of the reovirus hemagglutinin in viral virulence. Ann N Y Acad Sci. 1980; 354:125-34.
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Weiner HL, Schocket AL. Lymphocytes in multiple sclerosis: correlation with CSF immunoglobulins and cold-reactive lymphocytotoxic antibodies. Neurology. 1979 Nov; 29(11):1504-8.
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Hauser SL, Weiner HL, Bresnan MJ, Ault KA. Lymphocyte capping in muscular dystrophy. Neurology. 1979 Oct; 29(10):1419-21.
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Wechsler SL, Weiner HL, Fields BN. Immune response in subacute sclerosing panencephalitis: reduced antibody response to the matrix protein of measles virus. J Immunol. 1979 Aug; 123(2):884-9.
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Ault KA, Weiner HL. Natural killing of measles-infected cells by human lymphocytes. J Immunol. 1979 Jun; 122(6):2611-6.
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Finberg R, Weiner HL, Fields BN, Benacerraf B, Burakoff SJ. Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene. Proc Natl Acad Sci U S A. 1979 Jan; 76(1):442-6.
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Ackerman SH, Hofer MA, Weiner H. Predisposition to experimental ulcers. Gastroenterology. 1978 Nov; 75(5):930-1.
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Ackerman SH, Hofer MA, Weiner H. Predisposition to gastric erosions in the rat: behavioral and nutritional effects of early maternal separation. Gastroenterology. 1978 Oct; 75(4):649-54.
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Ault KA, Weiner HL. Isolation and characterization of the class of human blood lymphocytes responsible for antibody-dependent cellular cytotoxicity. Clin Immunol Immunopathol. 1978 Sep; 11(1):60-76.
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Scribner DJ, Weiner HL, Moorhead JW. Anti-immunoglobulin stimulation of murine lymphocytes. V. Age-related decline in Fc receptor-mediated immunoregulation. J Immunol. 1978 Jul; 121(1):377-82.
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Weiner HL, Scribner DJ, Moorhead JW. Anti-immunoglobulin stimulation of murine lymphocytes. IV. Re-expression and fate of cell surface receptors during stimulation. J Immunol. 1978 Jun; 120(6):1907-12.
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Weiner HL, Ramig RF, Mustoe TA, Fields BN. Identification of the gene coding for the hemagglutinin of reovirus. Virology. 1978 May 15; 86(2):581-4.
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Weiner HL, Cherry J, McIntosh K. Decreased lymphocyte transformation to vaccinia virus in multiple sclerosis. Neurology. 1978 May; 28(5):415-20.
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Schocket AL, Weiner HL. Lymphocytotoxic antibodies in family members of patients with multiple sclerosis. Lancet. 1978 Mar 18; 1(8064):571-3.
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Weiner HL, Scribner DJ, Schocket AL, Moorhead JW. Increased proliferative response of human peripheral blood lymphocytes to anti-immunoglobulin antibodies in elderly people. Clin Immunol Immunopathol. 1978 Mar; 9(3):356-62.
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Scribner DJ, Weiner HL, Moorhead JW. Surface immunoglobulin and Fc receptors on murine B lymphocytes: loss of receptor interaction after cell activation. J Immunol. 1977 Dec; 119(6):2084-8.
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Weiner HL, Drayna D, Averill DR, Fields BN. Molecular basis of reovirus virulence: role of the S1 gene. Proc Natl Acad Sci U S A. 1977 Dec; 74(12):5744-8.
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Weiner HL, Fields BN. Neutralization of reovirus: the gene responsible for the neutralization antigen. J Exp Med. 1977 Nov 1; 146(5):1305-10.
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Weiner HL, Scribner DJ, Moorhead JW. Anti-immunoglobulin stimulation of murine lymphocytes. III. Enhancement of the development of responsive B cells by thymic deprivation. Cell Immunol. 1977 Jun 1; 31(1):77-84.
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Weiner HL, Schocket AL, Lehrich JR. Lymphocytotix antibodies in subacute sclerosing panencephalitis and amyotrophic lateral sclerosis. Lancet. 1977 May 7; 1(8019):1013-4.
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Schocket AL, Weiner HL, Walker J, McIntosh K, Kohler PF. Lymphocytotoxic antibodies in multiple sclerosis. Clin Immunol Immunopathol. 1977 Jan; 7(1):15-23.
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Tank AW, Weiner H. The effects of ethanol on dopamine metabolism in rat liver and brain. Adv Exp Med Biol. 1977; 85A:473-83.
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Opelz G, Terasaki P, Myers L, Ellison G, Ebers G, Zabriskie J, Weiner H, Kempe H, Sibley W. The association of HLA antigens A3, B7, and DW2 with 330 multiple sclerosis patients in the United States. Tissue Antigens. 1977 Jan; 9(1):54-8.
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Weiner HL, Moorhead JW, Yamaga K, Kubo RT. Anti-immunoglobulin stimulation of murine lymphocytes. II. Identification of cell surface target molecules and requirements for cross-linkage. J Immunol. 1976 Nov; 117(5 Pt 1):1527-31.
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Weiner HL, Moorhead JW, Claman HN. Anti-immunoglobulin stimulation of murine lymphocytes. I. Age dependency of the proliferative response. J Immunol. 1976 Jun; 116(6):1656-61.
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Tank AW, Weiner H, Thurman JA. Ethanol-induced alterations of dopamine metabolism in rat liver. Ann N Y Acad Sci. 1976; 273:219-26.
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Boyar RM, Katz J, Finkelstein JW, Kapen S, Weiner H, Weitzman ED, Hellman L. Anorexia nervosa. Immaturity of the 24-hour luteinizing hormone secretory pattern. N Engl J Med. 1974 Oct 24; 291(17):861-5.
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Katz JL, Weiner H, Gutman A, Yu TF. Hyperuricemia, gout, and the executive suite. JAMA. 1973 May 28; 224(9):1251-7.
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Weiner H. Presidential address: some comments on the transduction of experience by the brain: implications for our understanding of the relationship of mind to body. Psychosom Med. 1972 Jul-Aug; 34(4):355-80.
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Amassian VE, Weiner H, Rosenblum M. Neural systems subserving the tactile placing reaction: a model for the study of higher level control of movement. Brain Res. 1972 May 12; 40(1):171-8.
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Coleman PL, Weiner H, Kaplan AM, Freeman MJ. The application of fluorescent emission and polarization for the measurement of association constants between fluorescein-conjugated protein antigens and antibodies. J Immunol Methods. 1972 Jan; 1(2):145-53.
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Ferguson SM, Rayport M, Gardner R, Kass W, Weiner H, Reiser MF. Similarities in mental content of psychotic states, spontaneous seizures, dreams, and responses to electrical brain stimulation in patients with temporal lobe epilepsy. Psychosom Med. 1969 Nov-Dec; 31(6):479-98.
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Katz J, Gallagher T, Hellman L, Sachar E, Weiner H. Psychoendocrine considerations in cancer of the breast. Ann N Y Acad Sci. 1969 Oct 14; 164(2):509-16.
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Weiner H. Less drug reactions in Jews? N Engl J Med. 1969 Sep 25; 281(13):740.
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Meurice E, Weiner H. [Electroencephalographic and electrodermographic activity parallel to a time reproduction human behavior]. Rev Neurol (Paris). 1965 Sep; 113(3):369-71.
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