Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Keywords
Last Name
Institution

Lee Josephson, PH.D.

TitleAssociate Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
Ctr for Molecular Imaging, Room 5406
149 13th Street
Charlestown MA 02129
Phone617/726-8354

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Yuan H, Cho H, Chen HH, Panagia M, Sosnovik DE, Josephson L. Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria. Chem Commun (Camb). 2013 Oct 10; 49(88):10361-3.
    View in: PubMed
  2. Cho H, Guo Y, Sosnovik DE, Josephson L. Imaging DNA with fluorochrome bearing metals. Inorg Chem. 2013 Nov 4; 52(21):12216-22.
    View in: PubMed
  3. Chen HH, Mekkaoui C, Cho H, Ngoy S, Marinelli B, Waterman P, Nahrendorf M, Liao R, Josephson L, Sosnovik DE. Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo. Circ Cardiovasc Imaging. 2013 May 1; 6(3):441-7.
    View in: PubMed
  4. Guo Y, Yuan H, Cho H, Kuruppu D, Jokivarsi K, Agarwal A, Shah K, Josephson L. High efficiency diffusion molecular retention tumor targeting. PLoS One. 2013; 8(3):e58290.
    View in: PubMed
  5. Cho H, Alcantara D, Yuan H, Sheth RA, Chen HH, Huang P, Andersson SB, Sosnovik DE, Mahmood U, Josephson L. Fluorochrome-functionalized nanoparticles for imaging DNA in biological systems. ACS Nano. 2013 Mar 26; 7(3):2032-41.
    View in: PubMed
  6. Josephson L, Rudin M. Barriers to clinical translation with diagnostic drugs. J Nucl Med. 2013 Mar; 54(3):329-32.
    View in: PubMed
  7. Buckle T, Kuil J, van den Berg NS, Bunschoten A, Lamb HJ, Yuan H, Josephson L, Jonkers J, Borowsky AD, van Leeuwen FW. Use of a Single Hybrid Imaging Agent for Integration of Target Validation with In Vivo and Ex Vivo Imaging of Mouse Tumor Lesions Resembling Human DCIS. PLoS One. 2013; 8(1):e48324.
    View in: PubMed
  8. Guo Y, Yuan H, Rice WL, Kumar AT, Goergen CJ, Jokivarsi K, Josephson L. The PEG-Fluorochrome Shielding Approach for Targeted Probe Design. J Am Chem Soc. 2012 Nov 28; 134(47):19338-41.
    View in: PubMed
  9. Pelaz B, Jaber S, de Aberasturi DJ, Wulf V, Aida T, de la Fuente JM, Feldmann J, Gaub HE, Josephson L, Kagan CR, Kotov NA, Liz-Marzán LM, Mattoussi H, Mulvaney P, Murray CB, Rogach AL, Weiss PS, Willner I, Parak WJ. The state of nanoparticle-based nanoscience and biotechnology: progress, promises, and challenges. ACS Nano. 2012 Oct 23; 6(10):8468-83.
    View in: PubMed
  10. Alcantara D, Guo Y, Yuan H, Goergen CJ, Chen HH, Cho H, Sosnovik DE, Josephson L. Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance. Angew Chem Int Ed Engl. 2012 Jul 9; 51(28):6904-7.
    View in: PubMed
  11. Bunschoten A, Buckle T, Visser NL, Kuil J, Yuan H, Josephson L, Vahrmeijer AL, van Leeuwen FW. Multimodal interventional molecular imaging of tumor margins and distant metastases by targeting avß3 integrin. Chembiochem. 2012 May 7; 13(7):1039-45.
    View in: PubMed
  12. Chin PT, Beekman CA, Buckle T, Josephson L, van Leeuwen FW. Multispectral visualization of surgical safety-margins using fluorescent marker seeds. Am J Nucl Med Mol Imaging. 2012; 2(2):151-62.
    View in: PubMed
  13. Chen HH, Yuan H, Josephson L, Sosnovik DE. Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival. Theranostics. 2012; 2(2):148-55.
    View in: PubMed
  14. Kuil J, Buckle T, Oldenburg J, Yuan H, Borowsky AD, Josephson L, van Leeuwen FW. Hybrid peptide dendrimers for imaging of chemokine receptor 4 (CXCR4) expression. Mol Pharm. 2011 Dec 5; 8(6):2444-53.
    View in: PubMed
  15. Huang S, Chen HH, Yuan H, Dai G, Schuhle DT, Mekkaoui C, Ngoy S, Liao R, Caravan P, Josephson L, Sosnovik DE. Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium. Circ Cardiovasc Imaging. 2011 Nov; 4(6):729-37.
    View in: PubMed
  16. Chen HH, Feng Y, Zhang M, Chao W, Josephson L, Shaw SY, Sosnovik DE. Protective effect of the apoptosis-sensing nanoparticle AnxCLIO-Cy5.5. Nanomedicine. 2012 Apr; 8(3):291-8.
    View in: PubMed
  17. Kuil J, Buckle T, Yuan H, van den Berg NS, Oishi S, Fujii N, Josephson L, van Leeuwen FW. Synthesis and evaluation of a bimodal CXCR4 antagonistic peptide. Bioconjug Chem. 2011 May 18; 22(5):859-64.
    View in: PubMed
  18. Chen S, Alcantara D, Josephson L. A magnetofluorescent nanoparticle for ex-vivo cell labeling by covalently linking the drugs protamine and Feraheme. J Nanosci Nanotechnol. 2011 Apr; 11(4):3058-64.
    View in: PubMed
  19. Chen HH, Josephson L, Sosnovik DE. Imaging of apoptosis in the heart with nanoparticle technology. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011 Jan-Feb; 3(1):86-99.
    View in: PubMed
  20. Blois J, Smith A, Josephson L. The slow cell death response when screening chemotherapeutic agents. Cancer Chemother Pharmacol. 2011 Sep; 68(3):795-803.
    View in: PubMed
  21. Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M. High-resolution magnetic resonance imaging enhanced with superparamagnetic nanoparticles measures macrophage burden in atherosclerosis. Circulation. 2010 Oct 26; 122(17):1707-15.
    View in: PubMed
  22. Garanger E, Blois J, Hilderbrand SA, Shao F, Josephson L. Divergent oriented synthesis for the design of reagents for protein conjugation. J Comb Chem. 2010 Jan-Feb; 12(1):57-64.
    View in: PubMed
  23. Sheth RA, Josephson L, Mahmood U. Evaluation and clinically relevant applications of a fluorescent imaging analog to fluorodeoxyglucose positron emission tomography. J Biomed Opt. 2009 Nov-Dec; 14(6):064014.
    View in: PubMed
  24. Smith RA, Yuan H, Weissleder R, Cantley LC, Josephson L. A wortmannin-cetuximab as a double drug. Bioconjug Chem. 2009 Nov; 20(11):2185-9.
    View in: PubMed
  25. Koh I, Josephson L. Magnetic nanoparticle sensors. Sensors (Basel). 2009; 9(10):8130-45.
    View in: PubMed
  26. Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L. Molecular MRI of cardiomyocyte apoptosis with simultaneous delayed-enhancement MRI distinguishes apoptotic and necrotic myocytes in vivo: potential for midmyocardial salvage in acute ischemia. Circ Cardiovasc Imaging. 2009 Nov; 2(6):460-7.
    View in: PubMed
  27. Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A. Molecular MRI detects low levels of cardiomyocyte apoptosis in a transgenic model of chronic heart failure. Circ Cardiovasc Imaging. 2009 Nov; 2(6):468-75.
    View in: PubMed
  28. Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U. Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function. Arthritis Rheum. 2009 Aug; 60(8):2314-24.
    View in: PubMed
  29. Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L. A DNA-binding Gd chelate for the detection of cell death by MRI. Chem Commun (Camb). 2009 Aug 7; (29):4444-6.
    View in: PubMed
  30. Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L. The antiproliferative cytostatic effects of a self-activating viridin prodrug. Mol Cancer Ther. 2009 Jun; 8(6):1666-75.
    View in: PubMed
  31. Sheth RA, Tam JM, Maricevich MA, Josephson L, Mahmood U. Quantitative endovascular fluorescence-based molecular imaging through blood of arterial wall inflammation. Radiology. 2009 Jun; 251(3):813-21.
    View in: PubMed
  32. Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson L. A stabilized demethoxyviridin derivative inhibits PI3 kinase. Bioorg Med Chem Lett. 2009 Aug 1; 19(15):4223-7.
    View in: PubMed
  33. Koh I, Hong R, Weissleder R, Josephson L. Nanoparticle-target interactions parallel antibody-protein interactions. Anal Chem. 2009 May 1; 81(9):3618-22.
    View in: PubMed
  34. Islam T, Josephson L. Current state and future applications of active targeting in malignancies using superparamagnetic iron oxide nanoparticles. Cancer Biomark. 2009; 5(2):99-107.
    View in: PubMed
  35. Garanger E, Weissleder R, Josephson L. A multifunctional single-attachment-point reagent for controlled protein biotinylation. Bioconjug Chem. 2009 Jan; 20(1):170-3.
    View in: PubMed
  36. Cortez-Retamozo V, Swirski FK, Waterman P, Yuan H, Figueiredo JL, Newton AP, Upadhyay R, Vinegoni C, Kohler R, Blois J, Smith A, Nahrendorf M, Josephson L, Weissleder R, Pittet MJ. Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. J Clin Invest. 2008 Dec; 118(12):4058-66.
    View in: PubMed
  37. Perez JM, Grimm J, Josephson L, Weissleder R. Integrated nanosensors to determine levels and functional activity of human telomerase. Neoplasia. 2008 Oct; 10(10):1066-72.
    View in: PubMed
  38. Garanger E, Aikawa E, Reynolds F, Weissleder R, Josephson L. Simplified syntheses of complex multifunctional nanomaterials. Chem Commun (Camb). 2008 Oct 21; (39):4792-4.
    View in: PubMed
  39. Gee MS, Upadhyay R, Bergquist H, Alencar H, Reynolds F, Maricevich M, Weissleder R, Josephson L, Mahmood U. Human breast cancer tumor models: molecular imaging of drug susceptibility and dosing during HER2/neu-targeted therapy. Radiology. 2008 Sep; 248(3):925-35.
    View in: PubMed
  40. Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L. Slow self-activation enhances the potency of viridin prodrugs. J Med Chem. 2008 Aug 14; 51(15):4699-707.
    View in: PubMed
  41. Taktak S, Weissleder R, Josephson L. Electrode chemistry yields a nanoparticle-based NMR sensor for calcium. Langmuir. 2008 Jul 15; 24(14):7596-8.
    View in: PubMed
  42. Hong R, Cima MJ, Weissleder R, Josephson L. Magnetic microparticle aggregation for viscosity determination by MR. Magn Reson Med. 2008 Mar; 59(3):515-20.
    View in: PubMed
  43. Koh I, Hong R, Weissleder R, Josephson L. Sensitive NMR sensors detect antibodies to influenza. Angew Chem Int Ed Engl. 2008; 47(22):4119-21.
    View in: PubMed
  44. Gee MS, Upadhyay R, Bergquist H, Weissleder R, Josephson L, Mahmood U. Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment. Int J Cancer. 2007 Dec 1; 121(11):2492-500.
    View in: PubMed
  45. Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, Josephson L. Fate of a bioactive fluorescent wortmannin derivative in cells. Bioconjug Chem. 2008 Jan; 19(1):130-7.
    View in: PubMed
  46. Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L. Multiparameter magnetic relaxation switch assays. Anal Chem. 2007 Dec 1; 79(23):8863-9.
    View in: PubMed
  47. Kim GY, Josephson L, Langer R, Cima MJ. Magnetic relaxation switch detection of human chorionic gonadotrophin. Bioconjug Chem. 2007 Nov-Dec; 18(6):2024-8.
    View in: PubMed
  48. Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V. Fluorescence tomography and magnetic resonance imaging of myocardial macrophage infiltration in infarcted myocardium in vivo. Circulation. 2007 Mar 20; 115(11):1384-91.
    View in: PubMed
  49. Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L. Covalent reactions of wortmannin under physiological conditions. Chem Biol. 2007 Mar; 14(3):321-8.
    View in: PubMed
  50. Montet-Abou K, Montet X, Weissleder R, Josephson L. Cell internalization of magnetic nanoparticles using transfection agents. Mol Imaging. 2007 Jan-Feb; 6(1):1-9.
    View in: PubMed
  51. Montet X, Funovics M, Montet-Abou K, Weissleder R, Josephson L. Multivalent effects of RGD peptides obtained by nanoparticle display. J Med Chem. 2006 Oct 5; 49(20):6087-93.
    View in: PubMed
  52. Sun EY, Weissleder R, Josephson L. Continuous analyte sensing with magnetic nanoswitches. Small. 2006 Oct; 2(10):1144-7.
    View in: PubMed
  53. Montet X, Weissleder R, Josephson L. Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas. Bioconjug Chem. 2006 Jul-Aug; 17(4):905-11.
    View in: PubMed
  54. Montet X, Yuan H, Weissleder R, Josephson L. Enzyme-based visualization of receptor-ligand binding in tissues. Lab Invest. 2006 May; 86(5):517-25.
    View in: PubMed
  55. Sun EY, Josephson L, Weissleder R. "Clickable" nanoparticles for targeted imaging. Mol Imaging. 2006 Apr-Jun; 5(2):122-8.
    View in: PubMed
  56. Tréhin R, Figueiredo JL, Pittet MJ, Weissleder R, Josephson L, Mahmood U. Fluorescent nanoparticle uptake for brain tumor visualization. Neoplasia. 2006 Apr; 8(4):302-11.
    View in: PubMed
  57. Montet X, Montet-Abou K, Reynolds F, Weissleder R, Josephson L. Nanoparticle imaging of integrins on tumor cells. Neoplasia. 2006 Mar; 8(3):214-22.
    View in: PubMed
  58. Yuan H, Luo J, Weissleder R, Cantley L, Josephson L. Wortmannin-C20 conjugates generate wortmannin. J Med Chem. 2006 Jan 26; 49(2):740-7.
    View in: PubMed
  59. Sun EY, Josephson L, Kelly KA, Weissleder R. Development of nanoparticle libraries for biosensing. Bioconjug Chem. 2006 Jan-Feb; 17(1):109-13.
    View in: PubMed
  60. Pittet MJ, Swirski FK, Reynolds F, Josephson L, Weissleder R. Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles. Nat Protoc. 2006; 1(1):73-9.
    View in: PubMed
  61. Weissleder R, Kelly K, Sun EY, Shtatland T, Josephson L. Cell-specific targeting of nanoparticles by multivalent attachment of small molecules. Nat Biotechnol. 2005 Nov; 23(11):1418-23.
    View in: PubMed
  62. Funovics M, Montet X, Reynolds F, Weissleder R, Josephson L. Nanoparticles for the optical imaging of tumor E-selectin. Neoplasia. 2005 Oct; 7(10):904-11.
    View in: PubMed
  63. Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L. Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle. Magn Reson Med. 2005 Sep; 54(3):718-24.
    View in: PubMed
  64. Reynolds F, Weissleder R, Josephson L. Protamine as an efficient membrane-translocating peptide. Bioconjug Chem. 2005 Sep-Oct; 16(5):1240-5.
    View in: PubMed
  65. Montet-Abou K, Montet X, Weissleder R, Josephson L. Transfection agent induced nanoparticle cell loading. Mol Imaging. 2005 Jul-Sep; 4(3):165-71.
    View in: PubMed
  66. Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L. Synthesis and activity of C11-modified wortmannin probes for PI3 kinase. Bioconjug Chem. 2005 May-Jun; 16(3):669-75.
    View in: PubMed
  67. Reynolds F, O'loughlin T, Weissleder R, Josephson L. Method of determining nanoparticle core weight. Anal Chem. 2005 Feb 1; 77(3):814-7.
    View in: PubMed
  68. Koch AM, Reynolds F, Merkle HP, Weissleder R, Josephson L. Transport of surface-modified nanoparticles through cell monolayers. Chembiochem. 2005 Feb; 6(2):337-45.
    View in: PubMed
  69. Kelly KA, Allport JR, Tsourkas A, Shinde-Patil VR, Josephson L, Weissleder R. Detection of vascular adhesion molecule-1 expression using a novel multimodal nanoparticle. Circ Res. 2005 Feb 18; 96(3):327-36.
    View in: PubMed
  70. Choi HK, Yessayan D, Choi HJ, Schellenberger E, Bogdanov A, Josephson L, Weissleder R, Ntziachristos V. Quantitative analysis of chemotherapeutic effects in tumors using in vivo staining and correlative histology. Cell Oncol. 2005; 27(3):183-90.
    View in: PubMed
  71. Wunder A, Schellenberger E, Mahmood U, Bogdanov A, Müller-Ladner U, Weissleder R, Josephson L. Methotrexate-induced accumulation of fluorescent annexin V in collagen-induced arthritis. Mol Imaging. 2005 Jan-Mar; 4(1):1-6.
    View in: PubMed
  72. Schellenberger EA, Sosnovik D, Weissleder R, Josephson L. Magneto/optical annexin V, a multimodal protein. Bioconjug Chem. 2004 Sep-Oct; 15(5):1062-7.
    View in: PubMed
  73. Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A, Josephson L, Weissleder R. Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12294-9.
    View in: PubMed
  74. Kelly KA, Reynolds F, Weissleder R, Josephson L. Fluorescein isothiocyanate-hapten immunoassay for determination of peptide-cell interactions. Anal Biochem. 2004 Jul 15; 330(2):181-5.
    View in: PubMed
  75. Schellingerhout D, Josephson L. Molecular imaging of cell-based therapies. Neuroimaging Clin N Am. 2004 May; 14(2):331-42, ix.
    View in: PubMed
  76. Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L. Magnetic relaxation switch immunosensors detect enantiomeric impurities. Angew Chem Int Ed Engl. 2004 Apr 26; 43(18):2395-9.
    View in: PubMed
  77. Schellenberger EA, Reynolds F, Weissleder R, Josephson L. Surface-functionalized nanoparticle library yields probes for apoptotic cells. Chembiochem. 2004 Mar 5; 5(3):275-9.
    View in: PubMed
  78. Perez JM, Josephson L, Weissleder R. Use of magnetic nanoparticles as nanosensors to probe for molecular interactions. Chembiochem. 2004 Mar 5; 5(3):261-4.
    View in: PubMed
  79. Schellenberger EA, Weissleder R, Josephson L. Optimal modification of annexin V with fluorescent dyes. Chembiochem. 2004 Mar 5; 5(3):271-4.
    View in: PubMed
  80. Kircher MF, Weissleder R, Josephson L. A dual fluorochrome probe for imaging proteases. Bioconjug Chem. 2004 Mar-Apr; 15(2):242-8.
    View in: PubMed
  81. Grimm J, Perez JM, Josephson L, Weissleder R. Novel nanosensors for rapid analysis of telomerase activity. Cancer Res. 2004 Jan 15; 64(2):639-43.
    View in: PubMed
  82. Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L. A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation. Cancer Res. 2003 Dec 1; 63(23):8122-5.
    View in: PubMed
  83. Koch AM, Reynolds F, Kircher MF, Merkle HP, Weissleder R, Josephson L. Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cells. Bioconjug Chem. 2003 Nov-Dec; 14(6):1115-21.
    View in: PubMed
  84. Högemann-Savellano D, Bos E, Blondet C, Sato F, Abe T, Josephson L, Weissleder R, Gaudet J, Sgroi D, Peters PJ, Basilion JP. The transferrin receptor: a potential molecular imaging marker for human cancer. Neoplasia. 2003 Nov-Dec; 5(6):495-506.
    View in: PubMed
  85. Kircher MF, Allport JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R. In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors. Cancer Res. 2003 Oct 15; 63(20):6838-46.
    View in: PubMed
  86. Perez JM, Simeone FJ, Saeki Y, Josephson L, Weissleder R. Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media. J Am Chem Soc. 2003 Aug 27; 125(34):10192-3.
    View in: PubMed
  87. Schellenberger EA, Bogdanov A, Petrovsky A, Ntziachristos V, Weissleder R, Josephson L. Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy. Neoplasia. 2003 May-Jun; 5(3):187-92.
    View in: PubMed
  88. Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A. Near-infrared fluorescent imaging of tumor apoptosis. Cancer Res. 2003 Apr 15; 63(8):1936-42.
    View in: PubMed
  89. Zhao M, Josephson L, Tang Y, Weissleder R. Magnetic sensors for protease assays. Angew Chem Int Ed Engl. 2003 Mar 28; 42(12):1375-8.
    View in: PubMed
  90. Josephson L, Mahmood U, Wunderbaldinger P, Tang Y, Weissleder R. Pan and sentinel lymph node visualization using a near-infrared fluorescent probe. Mol Imaging. 2003 Jan; 2(1):18-23.
    View in: PubMed
  91. Wunderbaldinger P, Josephson L, Weissleder R. Crosslinked iron oxides (CLIO): a new platform for the development of targeted MR contrast agents. Acad Radiol. 2002 Aug; 9 Suppl 2:S304-6.
    View in: PubMed
  92. Schellenberger EA, Högemann D, Josephson L, Weissleder R. Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Acad Radiol. 2002 Aug; 9 Suppl 2:S310-1.
    View in: PubMed
  93. Perez JM, Josephson L, O'Loughlin T, Högemann D, Weissleder R. Magnetic relaxation switches capable of sensing molecular interactions. Nat Biotechnol. 2002 Aug; 20(8):816-20.
    View in: PubMed
  94. Zhao M, Kircher MF, Josephson L, Weissleder R. Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake. Bioconjug Chem. 2002 Jul-Aug; 13(4):840-4.
    View in: PubMed
  95. Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R. Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes. Bioconjug Chem. 2002 May-Jun; 13(3):554-60.
    View in: PubMed
  96. Kircher MF, Josephson L, Weissleder R. Ratio imaging of enzyme activity using dual wavelength optical reporters. Mol Imaging. 2002 Apr-Jun; 1(2):89-95.
    View in: PubMed
  97. Schellenberger EA, Bogdanov A, Högemann D, Tait J, Weissleder R, Josephson L. Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Mol Imaging. 2002 Apr-Jun; 1(2):102-7.
    View in: PubMed
  98. Perez JM, O'Loughin T, Simeone FJ, Weissleder R, Josephson L. DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents. J Am Chem Soc. 2002 Mar 27; 124(12):2856-7.
    View in: PubMed
  99. Wunderbaldinger P, Josephson L, Weissleder R. Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles. Bioconjug Chem. 2002 Mar-Apr; 13(2):264-8.
    View in: PubMed
  100. Wunderbaldinger P, Josephson L, Bremer C, Moore A, Weissleder R. Detection of lymph node metastases by contrast-enhanced MRI in an experimental model. Magn Reson Med. 2002 Feb; 47(2):292-7.
    View in: PubMed
  101. Högemann D, Ntziachristos V, Josephson L, Weissleder R. High throughput magnetic resonance imaging for evaluating targeted nanoparticle probes. Bioconjug Chem. 2002 Jan-Feb; 13(1):116-21.
    View in: PubMed
  102. Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A. Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjug Chem. 2002 Jan-Feb; 13(1):122-7.
    View in: PubMed
  103. Dodd CH, Hsu HC, Chu WJ, Yang P, Zhang HG, Mountz JD, Zinn K, Forder J, Josephson L, Weissleder R, Mountz JM, Mountz JD. Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles. J Immunol Methods. 2001 Oct 1; 256(1-2):89-105.
    View in: PubMed
  104. Moore A, Josephson L, Bhorade RM, Basilion JP, Weissleder R. Human transferrin receptor gene as a marker gene for MR imaging. Radiology. 2001 Oct; 221(1):244-50.
    View in: PubMed
  105. Högemann D, Josephson L, Weissleder R, Basilion JP. Improvement of MRI probes to allow efficient detection of gene expression. Bioconjug Chem. 2000 Nov-Dec; 11(6):941-6.
    View in: PubMed
  106. Josephson L, Tung CH, Moore A, Weissleder R. High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates. Bioconjug Chem. 1999 Mar-Apr; 10(2):186-91.
    View in: PubMed
  107. Weissleder R, Elizondo G, Wittenberg J, Lee AS, Josephson L, Brady TJ. Ultrasmall superparamagnetic iron oxide: an intravenous contrast agent for assessing lymph nodes with MR imaging. Radiology. 1990 May; 175(2):494-8.
    View in: PubMed
  108. Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH, Josephson L. Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology. 1990 May; 175(2):489-93.
    View in: PubMed
  109. Weissleder R, Elizondo G, Josephson L, Compton CC, Fretz CJ, Stark DD, Ferrucci JT. Experimental lymph node metastases: enhanced detection with MR lymphography. Radiology. 1989 Jun; 171(3):835-9.
    View in: PubMed
  110. Cantley LC, Cantley LG, Josephson L. A characterization of vanadate interactions with the (Na,K)-ATPase. Mechanistic and regulatory implications. J Biol Chem. 1978 Oct 25; 253(20):7361-8.
    View in: PubMed
  111. Cantley LC, Gelles J, Josephson L. Reaction of (Na-K)ATPase with 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole: evidence for an essential tyrosine at the active site. Biochemistry. 1978 Feb 7; 17(3):418-25.
    View in: PubMed
  112. Cantley LC, Josephson L, Warner R, Yanagisawa M, Lechene C, Guidotti G. Vanadate is a potent (Na,K)-ATPase inhibitor found in ATP derived from muscle. J Biol Chem. 1977 Nov 10; 252(21):7421-3.
    View in: PubMed
  113. Josephson L, Cantley LC. Isolation of a potent (Na-K)ATPase inhibitor from striated muscle. Biochemistry. 1977 Oct 18; 16(21):4572-8.
    View in: PubMed
  114. Cantley LC, Josephson L. A slow interconversion between active and inactive states of the (Na-K)ATPase. Biochemistry. 1976 Nov 30; 15(24):5280-7.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact Human Resources at faculty_serviceshms.harvard.edu.
Josephson's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
Co-Authors
_
Similar People
_
Same Department
Physical Neighbors
_