 K Frank Austen, M.D.
| Title | Astrazeneca Professor of Respiratory and Inflammatory Diseases in the Department of Medicine |
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| Institution | Brigham and Women's Hospital |
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| Department | Medicine |
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| Address | Brigham and Women's Hospital
Smith Bldg 638
1 Jimmy Fund Way
Boston MA 02115
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| Phone | 617/525-1300 |
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| Fax | 617/525-1310 |
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 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
Faculty can login to make corrections and additions.
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Bartnikas LM, Gurish MF, Burton OT, Leisten S, Janssen E, Oettgen HC, Beaupré J, Lewis CN, Austen KF, Schulte S, Hornick JL, Geha RS, Oyoshi MK. Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J Allergy Clin Immunol. 2013 Feb; 131(2):451-460.e6.
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Liu AY, Dwyer DF, Jones TG, Bankova LG, Shen S, Katz HR, Austen KF, Gurish MF. Mast Cells Recruited to Mesenteric Lymph Nodes during Helminth Infection Remain Hypogranular and Produce IL-4 and IL-6. J Immunol. 2013 Feb 15; 190(4):1758-66.
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Barrett NA, Fernandez JM, Maekawa A, Xing W, Li L, Parsons MW, Austen KF, Kanaoka Y. Cysteinyl leukotriene 2 receptor on dendritic cells negatively regulates ligand-dependent allergic pulmonary inflammation. J Immunol. 2012 Nov 1; 189(9):4556-65.
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Gurish MF, Austen KF. Developmental origin and functional specialization of mast cell subsets. Immunity. 2012 Jul 27; 37(1):25-33.
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Oyoshi MK, He R, Kanaoka Y, ElKhal A, Kawamoto S, Lewis CN, Austen KF, Geha RS. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4992-7.
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Katz HR, Austen KF. Mast cell deficiency, a game of kit and mouse. Immunity. 2011 Nov 23; 35(5):668-70.
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Petersen B, Austen KF, Bloch KD, Hotta Y, Ichinose F, Kanaoka Y, Zapol WM. Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice. Anesthesiology. 2011 Oct; 115(4):804-11.
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Xing W, Austen KF, Gurish MF, Jones TG. Protease phenotype of constitutive connective tissue and of induced mucosal mast cells in mice is regulated by the tissue. Proc Natl Acad Sci U S A. 2011 Aug 23; 108(34):14210-5.
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Saino H, Ukita Y, Ago H, Irikura D, Nisawa A, Ueno G, Yamamoto M, Kanaoka Y, Lam BK, Austen KF, Miyano M. The catalytic architecture of leukotriene C4 synthase with two arginine residues. J Biol Chem. 2011 May 6; 286(18):16392-401.
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Barrett NA, Rahman OM, Fernandez JM, Parsons MW, Xing W, Austen KF, Kanaoka Y. Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes. J Exp Med. 2011 Mar 14; 208(3):593-604.
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Younan G, Suber F, Xing W, Shi T, Kunori Y, Abrink M, Pejler G, Schlenner SM, Rodewald HR, Moore FD, Stevens RL, Adachi R, Austen KF, Gurish MF. The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5. J Immunol. 2010 Dec 15; 185(12):7681-90.
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Jones TG, Finkelman FD, Austen KF, Gurish MF. T regulatory cells control antigen-induced recruitment of mast cell progenitors to the lungs of C57BL/6 mice. J Immunol. 2010 Aug 1; 185(3):1804-11.
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Maekawa A, Xing W, Austen KF, Kanaoka Y. GPR17 regulates immune pulmonary inflammation induced by house dust mites. J Immunol. 2010 Aug 1; 185(3):1846-54.
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Collington SJ, Hallgren J, Pease JE, Jones TG, Rollins BJ, Westwick J, Austen KF, Williams TJ, Gurish MF, Weller CL. The role of the CCL2/CCR2 axis in mouse mast cell migration in vitro and in vivo. J Immunol. 2010 Jun 1; 184(11):6114-23.
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Jones TG, Hallgren J, Humbles A, Burwell T, Finkelman FD, Alcaide P, Austen KF, Gurish MF. Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells. J Immunol. 2009 Oct 15; 183(8):5251-60.
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Barrett NA, Austen KF. Innate cells and T helper 2 cell immunity in airway inflammation. Immunity. 2009 Sep 18; 31(3):425-37.
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Austen KF, Maekawa A, Kanaoka Y, Boyce JA. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. J Allergy Clin Immunol. 2009 Sep; 124(3):406-14; quiz 415-6.
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Maekawa A, Balestrieri B, Austen KF, Kanaoka Y. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. Proc Natl Acad Sci U S A. 2009 Jul 14; 106(28):11685-90.
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Barrett NA, Maekawa A, Rahman OM, Austen KF, Kanaoka Y. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol. 2009 Jan 15; 182(2):1119-28.
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Blossom DB, Kallen AJ, Patel PR, Elward A, Robinson L, Gao G, Langer R, Perkins KM, Jaeger JL, Kurkjian KM, Jones M, Schillie SF, Shehab N, Ketterer D, Venkataraman G, Kishimoto TK, Shriver Z, McMahon AW, Austen KF, Kozlowski S, Srinivasan A, Turabelidze G, Gould CV, Arduino MJ, Sasisekharan R. Outbreak of adverse reactions associated with contaminated heparin. N Engl J Med. 2008 Dec 18; 359(25):2674-84.
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Maekawa A, Kanaoka Y, Xing W, Austen KF. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. Proc Natl Acad Sci U S A. 2008 Oct 28; 105(43):16695-700.
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Kishimoto TK, Viswanathan K, Ganguly T, Elankumaran S, Smith S, Pelzer K, Lansing JC, Sriranganathan N, Zhao G, Galcheva-Gargova Z, Al-Hakim A, Bailey GS, Fraser B, Roy S, Rogers-Cotrone T, Buhse L, Whary M, Fox J, Nasr M, Dal Pan GJ, Shriver Z, Langer RS, Venkataraman G, Austen KF, Woodcock J, Sasisekharan R. Contaminated heparin associated with adverse clinical events and activation of the contact system. N Engl J Med. 2008 Jun 5; 358(23):2457-67.
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Austen KF. The cysteinyl leukotrienes: where do they come from? What are they? Where are they going? Nat Immunol. 2008 Feb; 9(2):113-5.
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Austen KF. Doing what I like. Annu Rev Immunol. 2008; 26:1-28.
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Hallgren J, Jones TG, Abonia JP, Xing W, Humbles A, Austen KF, Gurish MF. Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20478-83.
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Zhou JS, Xing W, Friend DS, Austen KF, Katz HR. Mast cell deficiency in Kit(W-sh) mice does not impair antibody-mediated arthritis. J Exp Med. 2007 Nov 26; 204(12):2797-802.
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Ago H, Kanaoka Y, Irikura D, Lam BK, Shimamura T, Austen KF, Miyano M. Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis. Nature. 2007 Aug 2; 448(7153):609-12.
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Austen KF. Additional functions for the cysteinyl leukotrienes recognized through studies of inflammatory processes in null strains. Prostaglandins Other Lipid Mediat. 2007 May; 83(3):182-7.
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Austen KF. The National Institute of Allergy and Infectious Diseases' Asthma and Allergic Disease Centers: a personal commentary. J Allergy Clin Immunol. 2007 Jan; 119(1):34-5.
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Abonia JP, Hallgren J, Jones T, Shi T, Xu Y, Koni P, Flavell RA, Boyce JA, Austen KF, Gurish MF. Alpha-4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Blood. 2006 Sep 1; 108(5):1588-94.
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Kim DC, Hsu FI, Barrett NA, Friend DS, Grenningloh R, Ho IC, Al-Garawi A, Lora JM, Lam BK, Austen KF, Kanaoka Y. Cysteinyl leukotrienes regulate Th2 cell-dependent pulmonary inflammation. J Immunol. 2006 Apr 1; 176(7):4440-8.
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Chen M, Lam BK, Kanaoka Y, Nigrovic PA, Audoly LP, Austen KF, Lee DM. Neutrophil-derived leukotriene B4 is required for inflammatory arthritis. J Exp Med. 2006 Apr 17; 203(4):837-42.
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Arinobu Y, Iwasaki H, Gurish MF, Mizuno S, Shigematsu H, Ozawa H, Tenen DG, Austen KF, Akashi K. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18105-10.
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Boyce JA, Austen KF. No audible wheezing: nuggets and conundrums from mouse asthma models. J Exp Med. 2005 Jun 20; 201(12):1869-73.
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Abonia JP, Friend DS, Austen WG, Moore FD, Carroll MC, Chan R, Afnan J, Humbles A, Gerard C, Knight P, Kanaoka Y, Yasuda S, Morokawa N, Austen KF, Stevens RL, Gurish MF. Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle. J Immunol. 2005 Jun 1; 174(11):7285-91.
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Zhou JS, Friend DS, Lee DM, Li L, Austen KF, Katz HR. gp49B1 deficiency is associated with increases in cytokine and chemokine production and severity of proliferative synovitis induced by anti-type II collagen mAb. Eur J Immunol. 2005 May; 35(5):1530-8.
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Abonia JP, Austen KF, Rollins BJ, Joshi SK, Flavell RA, Kuziel WA, Koni PA, Gurish MF. Constitutive homing of mast cell progenitors to the intestine depends on autologous expression of the chemokine receptor CXCR2. Blood. 2005 Jun 1; 105(11):4308-13.
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Austen KF. The mast cell and the cysteinyl leukotrienes. Novartis Found Symp. 2005; 271:166-75; discussion 176-8, 198-9.
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Schmidt-Krey I, Kanaoka Y, Mills DJ, Irikura D, Haase W, Lam BK, Austen KF, Kühlbrandt W. Human leukotriene C(4) synthase at 4.5 A resolution in projection. Structure. 2004 Nov; 12(11):2009-14.
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Austen KF. Acceptance of the Kober Medal: It only gets better. J Clin Invest. 2004 Oct; 114(8):1177.
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Beller TC, Maekawa A, Friend DS, Austen KF, Kanaoka Y. Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J Biol Chem. 2004 Oct 29; 279(44):46129-34.
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Bagga S, Price KS, Lin DA, Friend DS, Austen KF, Boyce JA. Lysophosphatidic acid accelerates the development of human mast cells. Blood. 2004 Dec 15; 104(13):4080-7.
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Sloane DE, Tedla N, Awoniyi M, Macglashan DW, Borges L, Austen KF, Arm JP. Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. Blood. 2004 Nov 1; 104(9):2832-9.
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Beller TC, Friend DS, Maekawa A, Lam BK, Austen KF, Kanaoka Y. Cysteinyl leukotriene 1 receptor controls the severity of chronic pulmonary inflammation and fibrosis. Proc Natl Acad Sci U S A. 2004 Mar 2; 101(9):3047-52.
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Zhou JS, Friend DS, Feldweg AM, Daheshia M, Li L, Austen KF, Katz HR. Prevention of lipopolysaccharide-induced microangiopathy by gp49B1: evidence for an important role for gp49B1 expression on neutrophils. J Exp Med. 2003 Oct 20; 198(8):1243-51.
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Mellor EA, Frank N, Soler D, Hodge MR, Lora JM, Austen KF, Boyce JA. Expression of the type 2 receptor for cysteinyl leukotrienes (CysLT2R) by human mast cells: Functional distinction from CysLT1R. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11589-93.
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Feldweg AM, Friend DS, Zhou JS, Kanaoka Y, Daheshia M, Li L, Austen KF, Katz HR. gp49B1 suppresses stem cell factor-induced mast cell activation-secretion and attendant inflammation in vivo. Eur J Immunol. 2003 Aug; 33(8):2262-8.
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Arm JP, Austen KF. Leukotriene receptors and aspirin sensitivity. N Engl J Med. 2002 Nov 7; 347(19):1524-6.
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Lam BK, Austen KF. Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes. Prostaglandins Other Lipid Mediat. 2002 Aug; 68-69:511-20.
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Gurish MF, Humbles A, Tao H, Finkelstein S, Boyce JA, Gerard C, Friend DS, Austen KF. CCR3 is required for tissue eosinophilia and larval cytotoxicity after infection with Trichinella spiralis. J Immunol. 2002 Jun 1; 168(11):5730-6.
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Maekawa A, Austen KF, Kanaoka Y. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. J Biol Chem. 2002 Jun 7; 277(23):20820-4.
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Mellor EA, Austen KF, Boyce JA. Cysteinyl leukotrienes and uridine diphosphate induce cytokine generation by human mast cells through an interleukin 4-regulated pathway that is inhibited by leukotriene receptor antagonists. J Exp Med. 2002 Mar 4; 195(5):583-92.
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Castells M, Austen KF. Mastocytosis: mediator-related signs and symptoms. Int Arch Allergy Immunol. 2002 Feb; 127(2):147-52.
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Seymour ML, Rak S, Aberg D, Riise GC, Penrose JF, Kanaoka Y, Austen KF, Holgate ST, Sampson AP. Leukotriene and prostanoid pathway enzymes in bronchial biopsies of seasonal allergic asthmatics. Am J Respir Crit Care Med. 2001 Dec 1; 164(11):2051-6.
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Gurish MF, Tao H, Abonia JP, Arya A, Friend DS, Parker CM, Austen KF. Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing. J Exp Med. 2001 Nov 5; 194(9):1243-52.
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Mukundan C, Gurish MF, Austen KF, Hechtman HB, Friend DS. Mast cell mediation of muscle and pulmonary injury following hindlimb ischemia-reperfusion. J Histochem Cytochem. 2001 Aug; 49(8):1055-6.
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Daheshia M, Friend DS, Grusby MJ, Austen KF, Katz HR. Increased severity of local and systemic anaphylactic reactions in gp49B1-deficient mice. J Exp Med. 2001 Jul 16; 194(2):227-34.
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Mellor EA, Maekawa A, Austen KF, Boyce JA. Cysteinyl leukotriene receptor 1 is also a pyrimidinergic receptor and is expressed by human mast cells. Proc Natl Acad Sci U S A. 2001 Jul 3; 98(14):7964-9.
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Gurish MF, Austen KF. The diverse roles of mast cells. J Exp Med. 2001 Jul 2; 194(1):F1-5.
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Austen KF, Boyce JA. Mast cell lineage development and phenotypic regulation. Leuk Res. 2001 Jul; 25(7):511-8.
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Valent P, Horny HP, Escribano L, Longley BJ, Li CY, Schwartz LB, Marone G, Nuñez R, Akin C, Sotlar K, Sperr WR, Wolff K, Brunning RD, Parwaresch RM, Austen KF, Lennert K, Metcalfe DD, Vardiman JW, Bennett JM. Diagnostic criteria and classification of mastocytosis: a consensus proposal. Leuk Res. 2001 Jul; 25(7):603-25.
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Mukundan C, Gurish MF, Austen KF, Hechtman HB, Friend DS. The presence of v-abl-transformed V3 mast cells in the lungs augments pulmonary vascular permeability to acid aspiration. J Histochem Cytochem. 2001 Jun; 49(6):793-4.
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Castells MC, Klickstein LB, Hassani K, Cumplido JA, Lacouture ME, Austen KF, Katz HR. gp49B1-alpha(v)beta3 interaction inhibits antigen-induced mast cell activation. Nat Immunol. 2001 May; 2(5):436-42.
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Kanaoka Y, Maekawa A, Penrose JF, Austen KF, Lam BK. Attenuated zymosan-induced peritoneal vascular permeability and IgE-dependent passive cutaneous anaphylaxis in mice lacking leukotriene C4 synthase. J Biol Chem. 2001 Jun 22; 276(25):22608-13.
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Ho IC, Arm JP, Bingham CO, Choi A, Austen KF, Glimcher LH. A novel group of phospholipase A2s preferentially expressed in type 2 helper T cells. J Biol Chem. 2001 May 25; 276(21):18321-6.
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Maekawa A, Kanaoka Y, Lam BK, Austen KF. Identification in mice of two isoforms of the cysteinyl leukotriene 1 receptor that result from alternative splicing. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2256-61.
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Hsieh FH, Lam BK, Penrose JF, Austen KF, Boyce JA. T helper cell type 2 cytokines coordinately regulate immunoglobulin E-dependent cysteinyl leukotriene production by human cord blood-derived mast cells: profound induction of leukotriene C(4) synthase expression by interleukin 4. J Exp Med. 2001 Jan 1; 193(1):123-33.
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Ochi H, De Jesus NH, Hsieh FH, Austen KF, Boyce JA. IL-4 and -5 prime human mast cells for different profiles of IgE-dependent cytokine production. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10509-13.
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Friend DS, Gurish MF, Austen KF, Hunt J, Stevens RL. Senescent jejunal mast cells and eosinophils in the mouse preferentially translocate to the spleen and draining lymph node, respectively, during the recovery phase of helminth infection. J Immunol. 2000 Jul 1; 165(1):344-52.
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Zhao JL, Austen KF, Lam BK. Cell-specific transcription of leukotriene C(4) synthase involves a Kruppel-like transcription factor and Sp1. J Biol Chem. 2000 Mar 24; 275(12):8903-10.
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Bingham CO, Austen KF. Mast-cell responses in the development of asthma. J Allergy Clin Immunol. 2000 Feb; 105(2 Pt 2):S527-34.
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McCormick MJ, Castells MC, Austen KF, Katz HR. The gp49A gene has extensive sequence conservation with the gp49B gene and provides gp49A protein, a unique member of a large family of activating and inhibitory receptors of the immunoglobulin superfamily. Immunogenetics. 1999 Dec; 50(5-6):286-94.
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Bingham CO, Austen KF. Phospholipase A2 enzymes in eicosanoid generation. Proc Assoc Am Physicians. 1999 Nov-Dec; 111(6):516-24.
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Penrose JF, Austen KF. The biochemical, molecular, and genomic aspects of leukotriene C4 synthase. Proc Assoc Am Physicians. 1999 Nov-Dec; 111(6):537-46.
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Bingham CO, Fijneman RJ, Friend DS, Goddeau RP, Rogers RA, Austen KF, Arm JP. Low molecular weight group IIA and group V phospholipase A(2) enzymes have different intracellular locations in mouse bone marrow-derived mast cells. J Biol Chem. 1999 Oct 29; 274(44):31476-84.
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Ochi H, Hirani WM, Yuan Q, Friend DS, Austen KF, Boyce JA. T helper cell type 2 cytokine-mediated comitogenic responses and CCR3 expression during differentiation of human mast cells in vitro. J Exp Med. 1999 Jul 19; 190(2):267-80.
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Fujishima H, Sanchez Mejia RO, Bingham CO, Lam BK, Sapirstein A, Bonventre JV, Austen KF, Arm JP. Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells. Proc Natl Acad Sci U S A. 1999 Apr 27; 96(9):4803-7.
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Lu-Kuo JM, Joyal DM, Austen KF, Katz HR. gp49B1 inhibits IgE-initiated mast cell activation through both immunoreceptor tyrosine-based inhibitory motifs, recruitment of src homology 2 domain-containing phosphatase-1, and suppression of early and late calcium mobilization. J Biol Chem. 1999 Feb 26; 274(9):5791-6.
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Rosenkranz AR, Coxon A, Maurer M, Gurish MF, Austen KF, Friend DS, Galli SJ, Mayadas TN. Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice. J Immunol. 1998 Dec 15; 161(12):6463-7.
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Yuan Q, Gurish MF, Friend DS, Austen KF, Boyce JA. Generation of a novel stem cell factor-dependent mast cell progenitor. J Immunol. 1998 Nov 15; 161(10):5143-6.
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Friend DS, Ghildyal N, Gurish MF, Hunt J, Hu X, Austen KF, Stevens RL. Reversible expression of tryptases and chymases in the jejunal mast cells of mice infected with Trichinella spiralis. J Immunol. 1998 Jun 1; 160(11):5537-45.
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Hunt JE, Friend DS, Gurish MF, Feyfant E, Sali A, Huang C, Ghildyal N, Stechschulte S, Austen KF, Stevens RL. Mouse mast cell protease 9, a novel member of the chromosome 14 family of serine proteases that is selectively expressed in uterine mast cells. J Biol Chem. 1997 Nov 14; 272(46):29158-66.
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Penrose JF, Baldasaro MH, Webster M, Xu K, Austen KF, Lam BK. Molecular cloning of the gene for mouse leukotriene-C4 synthase. Eur J Biochem. 1997 Sep 15; 248(3):807-13.
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Arm JP, Nwankwo C, Austen KF. Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor. J Immunol. 1997 Sep 1; 159(5):2342-9.
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Yuan Q, Austen KF, Friend DS, Heidtman M, Boyce JA. Human peripheral blood eosinophils express a functional c-kit receptor for stem cell factor that stimulates very late antigen 4 (VLA-4)-mediated cell adhesion to fibronectin and vascular cell adhesion molecule 1 (VCAM-1). J Exp Med. 1997 Jul 21; 186(2):313-23.
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Katz HR, Austen KF. A newly recognized pathway for the negative regulation of mast cell-dependent hypersensitivity and inflammation mediated by an endogenous cell surface receptor of the gp49 family. J Immunol. 1997 Jun 1; 158(11):5065-70.
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Lam BK, Penrose JF, Xu K, Baldasaro MH, Austen KF. Site-directed mutagenesis of human leukotriene C4 synthase. J Biol Chem. 1997 May 23; 272(21):13923-8.
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Austen KF, Penrose JF. Characterization of the gene for leukotriene C4 synthase and its chromosomal localization. Int Arch Allergy Immunol. 1997 May-Jul; 113(1-3):51-4.
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Boyce JA, Lam BK, Penrose JF, Friend DS, Parsons S, Owen WF, Austen KF. Expression of LTC4 synthase during the development of eosinophils in vitro from cord blood progenitors. Blood. 1996 Dec 1; 88(11):4338-47.
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Bingham CO, Murakami M, Fujishima H, Hunt JE, Austen KF, Arm JP. A heparin-sensitive phospholipase A2 and prostaglandin endoperoxide synthase-2 are functionally linked in the delayed phase of prostaglandin D2 generation in mouse bone marrow-derived mast cells. J Biol Chem. 1996 Oct 18; 271(42):25936-44.
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Castells MC, Friend DS, Bunnell CA, Hu X, Kraus M, Osteen RT, Austen KF. The presence of membrane-bound stem cell factor on highly immature nonmetachromatic mast cells in the peripheral blood of a patient with aggressive systemic mastocytosis. J Allergy Clin Immunol. 1996 Oct; 98(4):831-40.
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Friend DS, Ghildyal N, Austen KF, Gurish MF, Matsumoto R, Stevens RL. Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype. J Cell Biol. 1996 Oct; 135(1):279-90.
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Katz HR, Vivier E, Castells MC, McCormick MJ, Chambers JM, Austen KF. Mouse mast cell gp49B1 contains two immunoreceptor tyrosine-based inhibition motifs and suppresses mast cell activation when coligated with the high-affinity Fc receptor for IgE. Proc Natl Acad Sci U S A. 1996 Oct 1; 93(20):10809-14.
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Huang MH, Friend DS, Sunday ME, Singh K, Haley K, Austen KF, Kelly RA, Smith TW. An intrinsic adrenergic system in mammalian heart. J Clin Invest. 1996 Sep 15; 98(6):1298-1303.
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Lu-Kuo JM, Austen KF, Katz HR. Post-transcriptional stabilization by interleukin-1beta of interleukin-6 mRNA induced by c-kit ligand and interleukin-10 in mouse bone marrow-derived mast cells. J Biol Chem. 1996 Sep 6; 271(36):22169-74.
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Ghildyal N, Friend DS, Stevens RL, Austen KF, Huang C, Penrose JF, Sali A, Gurish MF. Fate of two mast cell tryptases in V3 mastocytosis and normal BALB/c mice undergoing passive systemic anaphylaxis: prolonged retention of exocytosed mMCP-6 in connective tissues, and rapid accumulation of enzymatically active mMCP-7 in the blood. J Exp Med. 1996 Sep 1; 184(3):1061-73.
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Lam BK, Penrose JF, Rokach J, Xu K, Baldasaro MH, Austen KF. Molecular cloning, expression and characterization of mouse leukotriene C4 synthase. Eur J Biochem. 1996 Jun 15; 238(3):606-12.
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Penrose JF, Spector J, Baldasaro M, Xu K, Boyce J, Arm JP, Austen KF, Lam BK. Molecular cloning of the gene for human leukotriene C4 synthase. Organization, nucleotide sequence, and chromosomal localization to 5q35. J Biol Chem. 1996 May 10; 271(19):11356-61.
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Xia Z, Ghildyal N, Austen KF, Stevens RL. Post-transcriptional regulation of chymase expression in mast cells. A cytokine-dependent mechanism for controlling the expression of granule neutral proteases of hematopoietic cells. J Biol Chem. 1996 Apr 12; 271(15):8747-53.
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Boyce JA, Friend D, Gurish MF, Austen KF, Owen WF. Constitutive production of granulocyte/macrophage colony-stimulating factor by hypodense mononuclear eosinophils developed in vitro from hybrid eosinophil/basophil granulocytes. Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6):2436-41.
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Hunt JE, Stevens RL, Austen KF, Zhang J, Xia Z, Ghildyal N. Natural disruption of the mouse mast cell protease 7 gene in the C57BL/6 mouse. J Biol Chem. 1996 Feb 2; 271(5):2851-5.
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Du T, Friend DS, Austen KF, Katz HR. Tissue-dependent differences in the asynchronous appearance of mast cells in normal mice and in congenic mast cell-deficient mice after infusion of normal bone marrow cells. Clin Exp Immunol. 1996 Feb; 103(2):316-21.
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Drazen JM, Arm JP, Austen KF. Sorting out the cytokines of asthma. J Exp Med. 1996 Jan 1; 183(1):1-5.
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Murakami M, Bingham CO, Matsumoto R, Austen KF, Arm JP. IgE-dependent activation of cytokine-primed mouse cultured mast cells induces a delayed phase of prostaglandin D2 generation via prostaglandin endoperoxide synthase-2. J Immunol. 1995 Nov 1; 155(9):4445-53.
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Lam BK, Penrose JF, Xu K, Austen KF. Leukotriene C4 synthase. J Lipid Mediat Cell Signal. 1995 Oct; 12(2-3):333-41.
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Murakami M, Austen KF, Bingham CO, Friend DS, Penrose JF, Arm JP. Interleukin-3 regulates development of the 5-lipoxygenase/leukotriene C4 synthase pathway in mouse mast cells. J Biol Chem. 1995 Sep 29; 270(39):22653-6.
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Gurish MF, Pear WS, Stevens RL, Scott ML, Sokol K, Ghildyal N, Webster MJ, Hu X, Austen KF, Baltimore D, et al. Tissue-regulated differentiation and maturation of a v-abl-immortalized mast cell-committed progenitor. Immunity. 1995 Aug; 3(2):175-86.
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Murakami M, Austen KF, Arm JP. The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. J Exp Med. 1995 Jul 1; 182(1):197-206.
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Boyce JA, Friend D, Matsumoto R, Austen KF, Owen WF. Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate. J Exp Med. 1995 Jul 1; 182(1):49-57.
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Penrose JF, Spector J, Lam BK, Friend DS, Xu K, Jack RM, Austen KF. Purification of human lung leukotriene C4 synthase and preparation of a polyclonal antibody. Am J Respir Crit Care Med. 1995 Jul; 152(1):283-9.
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Murakami M, Penrose JF, Urade Y, Austen KF, Arm JP. Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):6107-11.
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Austen KF. The Paul Kallós Memorial Lecture. From slow-reacting substance of anaphylaxis to leukotriene C4 synthase. Int Arch Allergy Immunol. 1995 May-Jun; 107(1-3):19-24.
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Murakami M, Matsumoto R, Urade Y, Austen KF, Arm JP. c-kit ligand mediates increased expression of cytosolic phospholipase A2, prostaglandin endoperoxide synthase-1, and hematopoietic prostaglandin D2 synthase and increased IgE-dependent prostaglandin D2 generation in immature mouse mast cells. J Biol Chem. 1995 Feb 17; 270(7):3239-46.
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Fruman DA, Bierer BE, Benes JE, Burakoff SJ, Austen KF, Katz HR. The complex of FK506-binding protein 12 and FK506 inhibits calcineurin phosphatase activity and IgE activation-induced cytokine transcripts, but not exocytosis, in mouse mast cells. J Immunol. 1995 Feb 15; 154(4):1846-51.
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Lam BK, Penrose JF, Austen KF. Expression cloning of human LTC4 synthase. Adv Prostaglandin Thromboxane Leukot Res. 1995; 23:35-9.
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Murakami M, Arm JP, Austen KF. Cytokine regulation of mast cell protease phenotype and arachidonic acid metabolism. Ann N Y Acad Sci. 1994 Nov 15; 744:84-98.
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Ghildyal N, Friend DS, Freelund R, Austen KF, McNeil HP, Schiller V, Stevens RL. Lack of expression of the tryptase mouse mast cell protease 7 in mast cells of the C57BL/6J mouse. J Immunol. 1994 Sep 15; 153(6):2624-30.
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Murakami M, Matsumoto R, Austen KF, Arm JP. Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells. J Biol Chem. 1994 Sep 2; 269(35):22269-75.
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Lam BK, Penrose JF, Freeman GJ, Austen KF. Expression cloning of a cDNA for human leukotriene C4 synthase, an integral membrane protein conjugating reduced glutathione to leukotriene A4. Proc Natl Acad Sci U S A. 1994 Aug 2; 91(16):7663-7.
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Austen KF. Interactions of cells, cytokines, and mediators in bronchial asthma. Allergy Proc. 1994 Jul-Aug; 15(4):183-7.
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Eklund KK, Ghildyal N, Austen KF, Friend DS, Schiller V, Stevens RL. Mouse bone marrow-derived mast cells (mBMMC) obtained in vitro from mice that are mast cell-deficient in vivo express the same panel of granule proteases as mBMMC and serosal mast cells from their normal littermates. J Exp Med. 1994 Jul 1; 180(1):67-73.
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Castells MC, Wu X, Arm JP, Austen KF, Katz HR. Cloning of the gp49B gene of the immunoglobulin superfamily and demonstration that one of its two products is an early-expressed mast cell surface protein originally described as gp49. J Biol Chem. 1994 Mar 18; 269(11):8393-401.
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Lobell RB, Austen KF, Katz HR. Fc gamma R-mediated endocytosis and expression of cell surface Fc gamma RIIb1 and Fc gamma RIIb2 by mouse bone marrow culture-derived progenitor mast cells. J Immunol. 1994 Jan 15; 152(2):811-8.
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Stevens RL, Friend DS, McNeil HP, Schiller V, Ghildyal N, Austen KF. Strain-specific and tissue-specific expression of mouse mast cell secretory granule proteases. Proc Natl Acad Sci U S A. 1994 Jan 4; 91(1):128-32.
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McNeil HP, Austen KF. Cytokine regulation of mouse mast-cell-specific protease genes. Adv Prostaglandin Thromboxane Leukot Res. 1994; 22:71-81.
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Eklund KK, Ghildyal N, Austen KF, Stevens RL. Induction by IL-9 and suppression by IL-3 and IL-4 of the levels of chromosome 14-derived transcripts that encode late-expressed mouse mast cell proteases. J Immunol. 1993 Oct 15; 151(8):4266-73.
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Ghildyal N, Friend DS, Nicodemus CF, Austen KF, Stevens RL. Reversible expression of mouse mast cell protease 2 mRNA and protein in cultured mast cells exposed to IL-10. J Immunol. 1993 Sep 15; 151(6):3206-14.
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Gurish MF, Nadeau JH, Johnson KR, McNeil HP, Grattan KM, Austen KF, Stevens RL. A closely linked complex of mouse mast cell-specific chymase genes on chromosome 14. J Biol Chem. 1993 May 25; 268(15):11372-9.
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Weidner N, Austen KF. Heterogeneity of mast cells at multiple body sites. Fluorescent determination of avidin binding and immunofluorescent determination of chymase, tryptase, and carboxypeptidase content. Pathol Res Pract. 1993 Mar; 189(2):156-62.
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Martin TR, Takeishi T, Katz HR, Austen KF, Drazen JM, Galli SJ. Mast cell activation enhances airway responsiveness to methacholine in the mouse. J Clin Invest. 1993 Mar; 91(3):1176-82.
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Sperling RI, Benincaso AI, Knoell CT, Larkin JK, Austen KF, Robinson DR. Dietary omega-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. J Clin Invest. 1993 Feb; 91(2):651-60.
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Lobell RB, Arm JP, Raizman MB, Austen KF, Katz HR. Intracellular degradation of Fc gamma RIII in mouse bone marrow culture-derived progenitor mast cells prevents its surface expression and associated function. J Biol Chem. 1993 Jan 15; 268(2):1207-12.
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Penrose JF, Gagnon L, Goppelt-Struebe M, Myers P, Lam BK, Jack RM, Austen KF, Soberman RJ. Purification of human leukotriene C4 synthase. Proc Natl Acad Sci U S A. 1992 Dec 1; 89(23):11603-6.
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McNeil HP, Reynolds DS, Schiller V, Ghildyal N, Gurley DS, Austen KF, Stevens RL. Isolation, characterization, and transcription of the gene encoding mouse mast cell protease 7. Proc Natl Acad Sci U S A. 1992 Dec 1; 89(23):11174-8.
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Lam BK, Xu K, Atkins MB, Austen KF. Leukotriene C4 uses a probenecid-sensitive export carrier that does not recognize leukotriene B4. Proc Natl Acad Sci U S A. 1992 Dec 1; 89(23):11598-602.
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McNeil HP, Frenkel DP, Austen KF, Friend DS, Stevens RL. Translation and granule localization of mouse mast cell protease-5. Immunodetection with specific antipeptide Ig. J Immunol. 1992 Oct 1; 149(7):2466-72.
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Ghildyal N, McNeil HP, Stechschulte S, Austen KF, Silberstein D, Gurish MF, Somerville LL, Stevens RL. IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice. J Immunol. 1992 Sep 15; 149(6):2123-9.
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Ghildyal N, McNeil HP, Gurish MF, Austen KF, Stevens RL. Transcriptional regulation of the mucosal mast cell-specific protease gene, MMCP-2, by interleukin 10 and interleukin 3. J Biol Chem. 1992 Apr 25; 267(12):8473-7.
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Sperling RI, Benincaso AI, Anderson RJ, Coblyn JS, Austen KF, Weinblatt ME. Acute and chronic suppression of leukotriene B4 synthesis ex vivo in neutrophils from patients with rheumatoid arthritis beginning treatment with methotrexate. Arthritis Rheum. 1992 Apr; 35(4):376-84.
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Weidner N, Horan RF, Austen KF. Mast-cell phenotype in indolent forms of mastocytosis. Ultrastructural features, fluorescence detection of avidin binding, and immunofluorescent determination of chymase, tryptase, and carboxypeptidase. Am J Pathol. 1992 Apr; 140(4):847-57.
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Gurish MF, Ghildyal N, McNeil HP, Austen KF, Gillis S, Stevens RL. Differential expression of secretory granule proteases in mouse mast cells exposed to interleukin 3 and c-kit ligand. J Exp Med. 1992 Apr 1; 175(4):1003-12.
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Katz HR, Raizman MB, Gartner CS, Scott HC, Benson AC, Austen KF. Secretory granule mediator release and generation of oxidative metabolites of arachidonic acid via Fc-IgG receptor bridging in mouse mast cells. J Immunol. 1992 Feb 1; 148(3):868-71.
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Avraham S, Avraham H, Austen KF, Stevens RL. Negative and positive cis-acting elements in the promoter of the mouse gene that encodes the serine/glycine-rich peptide core of secretory granule proteoglycans. J Biol Chem. 1992 Jan 5; 267(1):610-7.
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Reynolds DS, Gurley DS, Austen KF. Cloning and characterization of the novel gene for mast cell carboxypeptidase A. J Clin Invest. 1992 Jan; 89(1):273-82.
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Zon LI, Gurish MF, Stevens RL, Mather C, Reynolds DS, Austen KF, Orkin SH. GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5; 266(34):22948-53.
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Katz HR, Kaye RE, Austen KF. Mast cell biochemical and functional heterogeneity. Transplant Proc. 1991 Dec; 23(6):2900-4.
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Her E, Frazer J, Austen KF, Owen WF. Eosinophil hematopoietins antagonize the programmed cell death of eosinophils. Cytokine and glucocorticoid effects on eosinophils maintained by endothelial cell-conditioned medium. J Clin Invest. 1991 Dec; 88(6):1982-7.
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McNeil HP, Austen KF, Somerville LL, Gurish MF, Stevens RL. Molecular cloning of the mouse mast cell protease-5 gene. A novel secretory granule protease expressed early in the differentiation of serosal mast cells. J Biol Chem. 1991 Oct 25; 266(30):20316-22.
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Arm JP, Gurish MF, Reynolds DS, Scott HC, Gartner CS, Austen KF, Katz HR. Molecular cloning of gp49, a cell-surface antigen that is preferentially expressed by mouse mast cell progenitors and is a new member of the immunoglobulin superfamily. J Biol Chem. 1991 Aug 25; 266(24):15966-73.
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Serafin WE, Guidry UA, Dayton ET, Kamada MM, Stevens RL, Austen KF. Identification of aminopeptidase activity in the secretory granules of mouse mast cells. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):5984-8.
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Owen WF, Petersen J, Austen KF. Eosinophils altered phenotypically and primed by culture with granulocyte/macrophage colony-stimulating factor and 3T3 fibroblasts generate leukotriene C4 in response to FMLP. J Clin Invest. 1991 Jun; 87(6):1958-63.
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Kay J, Austen KF, Czop JK. Identification and characterization of opsonic fibronectin in synovial fluids of patients with active rheumatoid arthritis. Arthritis Rheum. 1991 Jun; 34(6):687-96.
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Weidner N, Austen KF. Ultrastructural and immunohistochemical characterization of normal mast cells at multiple body sites. J Invest Dermatol. 1991 Mar; 96(3):26S-30S; discussion 30S-31S.
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Horan RF, Austen KF. Systemic mastocytosis: retrospective review of a decade's clinical experience at the Brigham and Women's Hospital. J Invest Dermatol. 1991 Mar; 96(3):5S-13S; discussion 13S-14S.
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Weidner N, Austen KF. Ultrastructural and immunohistochemical characterization of normal mast cells at multiple body sites. J Invest Dermatol. 1991 Mar; 96(3 Suppl):26S-30S; discussion 30S-31S, 60S-65S.
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Gurish MF, Ghildyal N, Arm J, Austen KF, Avraham S, Reynolds D, Stevens RL. Cytokine mRNA are preferentially increased relative to secretory granule protein mRNA in mouse bone marrow-derived mast cells that have undergone IgE-mediated activation and degranulation. J Immunol. 1991 Mar 1; 146(5):1527-33.
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Horan RF, Austen KF. Systemic mastocytosis: retrospective review of a decade's clinical experience at the Brigham and Women's Hospital. J Invest Dermatol. 1991 Mar; 96(3 Suppl):5S-13S; discussion 13S-14S, 60S-65S.
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Reynolds DS, Gurley DS, Austen KF, Serafin WE. Cloning of the cDNA and gene of mouse mast cell protease-6. Transcription by progenitor mast cells and mast cells of the connective tissue subclass. J Biol Chem. 1991 Feb 25; 266(6):3847-53.
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Serafin WE, Sullivan TP, Conder GA, Ebrahimi A, Marcham P, Johnson SS, Austen KF, Reynolds DS. Cloning of the cDNA and gene for mouse mast cell protease 4. Demonstration of its late transcription in mast cell subclasses and analysis of its homology to subclass-specific neutral proteases of the mouse and rat. J Biol Chem. 1991 Jan 25; 266(3):1934-41.
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Sheff DM, Owen WF, Austen KF. Eosinophil phenotypes and LTC4 generation in vitro and in hypereosinophilic states. Adv Prostaglandin Thromboxane Leukot Res. 1991; 21B:481-8.
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Katz HR, Arm JP, Benson AC, Austen KF. Maturation-related changes in the expression of Fc gamma RII and Fc gamma RIII on mouse mast cells derived in vitro and in vivo. J Immunol. 1990 Nov 15; 145(10):3412-7.
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Owen WF, Petersen J, Sheff DM, Folkerth RD, Anderson RJ, Corson JM, Sheffer AL, Austen KF. Hypodense eosinophils and interleukin 5 activity in the blood of patients with the eosinophilia-myalgia syndrome. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8647-51.
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Lewis RA, Austen KF, Soberman RJ. Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N Engl J Med. 1990 Sep 6; 323(10):645-55.
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Raizman MB, Austen KF, Katz HR. Mast cell heterogeneity. Differential synthesis and expression of glycosphingolipids by mouse serosal mast cells as compared to IL-3-dependent bone marrow culture-derived mast cells before or after coculture with 3T3 fibroblasts. J Immunol. 1990 Sep 1; 145(5):1463-8.
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Lam BK, Gagnon L, Austen KF, Soberman RJ. The mechanism of leukotriene B4 export from human polymorphonuclear leukocytes. J Biol Chem. 1990 Aug 15; 265(23):13438-41.
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Sperling RI, Coblyn JS, Larkin JK, Benincaso AI, Austen KF, Weinblatt ME. Inhibition of leukotriene B4 synthesis in neutrophils from patients with rheumatoid arthritis by a single oral dose of methotrexate. Arthritis Rheum. 1990 Aug; 33(8):1149-55.
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Caulfield JP, Hein A, Rothenberg ME, Owen WF, Soberman RJ, Stevens RL, Austen KF. A morphometric study of normodense and hypodense human eosinophils that are derived in vivo and in vitro. Am J Pathol. 1990 Jul; 137(1):27-41.
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Weidner N, Austen KF. Evidence for morphologic diversity of human mast cells. An ultrastructural study of mast cells from multiple body sites. Lab Invest. 1990 Jul; 63(1):63-72.
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Mirowski G, Austen KF, Chiang L, Horan RF, Sheffer AL, Weidner N, Murphy GF. Characterization of cellular dermal infiltrates in human cutaneous mastocytosis. Lab Invest. 1990 Jul; 63(1):52-62.
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Horan RF, Sheffer AL, Austen KF. Cromolyn sodium in the management of systemic mastocytosis. J Allergy Clin Immunol. 1990 May; 85(5):852-5.
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Nicodemus CF, Avraham S, Austen KF, Purdy S, Jablonski J, Stevens RL. Characterization of the human gene that encodes the peptide core of secretory granule proteoglycans in promyelocytic leukemia HL-60 cells and analysis of the translated product. J Biol Chem. 1990 Apr 5; 265(10):5889-96.
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Reynolds DS, Stevens RL, Lane WS, Carr MH, Austen KF, Serafin WE. Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases. Proc Natl Acad Sci U S A. 1990 Apr; 87(8):3230-4.
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Ling CJ, Owen WF, Austen KF. Human fibroblasts maintain the viability and augment the functional response of human neutrophils in culture. J Clin Invest. 1990 Feb; 85(2):601-4.
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Serafin WE, Reynolds DS, Rogelj S, Lane WS, Conder GA, Johnson SS, Austen KF, Stevens RL. Identification and molecular cloning of a novel mouse mucosal mast cell serine protease. J Biol Chem. 1990 Jan 5; 265(1):423-9.
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Reynolds DS, Gurley DS, Stevens RL, Sugarbaker DJ, Austen KF, Serafin WE. Cloning of cDNAs that encode human mast cell carboxypeptidase A, and comparison of the protein with mouse mast cell carboxypeptidase A and rat pancreatic carboxypeptidases. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9480-4.
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Reynolds DS, Stevens RL, Gurley DS, Lane WS, Austen KF, Serafin WE. Isolation and molecular cloning of mast cell carboxypeptidase A. A novel member of the carboxypeptidase gene family. J Biol Chem. 1989 Nov 25; 264(33):20094-9.
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Avraham S, Austen KF, Nicodemus CF, Gartner MC, Stevens RL. Cloning and characterization of the mouse gene that encodes the peptide core of secretory granule proteoglycans and expression of this gene in transfected rat-1 fibroblasts. J Biol Chem. 1989 Oct 5; 264(28):16719-26.
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Rothenberg ME, Petersen J, Stevens RL, Silberstein DS, McKenzie DT, Austen KF, Owen WF. IL-5-dependent conversion of normodense human eosinophils to the hypodense phenotype uses 3T3 fibroblasts for enhanced viability, accelerated hypodensity, and sustained antibody-dependent cytotoxicity. J Immunol. 1989 Oct 1; 143(7):2311-6.
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Sutyak J, Austen KF, Soberman RJ. Identification of an aldehyde dehydrogenase in the microsomes of human polymorphonuclear leukocytes that metabolizes 20-aldehyde leukotriene B4. J Biol Chem. 1989 Sep 5; 264(25):14818-23.
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Silberstein DS, Austen KF, Owen WF. Hemopoietins for eosinophils. Glycoprotein hormones that regulate the development of inflammation in eosinophilia-associated disease. Hematol Oncol Clin North Am. 1989 Sep; 3(3):511-33.
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Lam BK, Owen WF, Austen KF, Soberman RJ. The identification of a distinct export step following the biosynthesis of leukotriene C4 by human eosinophils. J Biol Chem. 1989 Aug 5; 264(22):12885-9.
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Pichurko BM, Ingram RH, Sperling RI, Lafleur JE, Corey EJ, Austen KF, Drazen JM. Localization of the site of the bronchoconstrictor effects of leukotriene C4 compared with that of histamine in asthmatic subjects. Am Rev Respir Dis. 1989 Aug; 140(2):334-9.
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Owen WF, Rothenberg ME, Petersen J, Weller PF, Silberstein D, Sheffer AL, Stevens RL, Soberman RJ, Austen KF. Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome. J Exp Med. 1989 Jul 1; 170(1):343-8.
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Dayton ET, Caulfield JP, Hein A, Austen KF, Stevens RL. Regulation of the growth rate of mouse fibroblasts by IL-3-activated mouse bone marrow-derived mast cells. J Immunol. 1989 Jun 15; 142(12):4307-13.
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Avraham S, Stevens RL, Nicodemus CF, Gartner MC, Austen KF, Weis JH. Molecular cloning of a cDNA that encodes the peptide core of a mouse mast cell secretory granule proteoglycan and comparison with the analogous rat and human cDNA. Proc Natl Acad Sci U S A. 1989 May; 86(10):3763-7.
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Janusz MJ, Austen KF, Czop JK. Isolation of a yeast heptaglucoside that inhibits monocyte phagocytosis of zymosan particles. J Immunol. 1989 Feb 1; 142(3):959-65.
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Katz HR, Benson AC, Austen KF. Activation- and phorbol ester-stimulated phosphorylation of a plasma membrane glycoprotein antigen expressed on mouse IL-3-dependent mast cells and serosal mast cells. J Immunol. 1989 Feb 1; 142(3):919-26.
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Kamada MM, Michon J, Ritz J, Holldack J, Serafin WE, Austen KF, MacDermott RP, Stevens RL. Identification of carboxypeptidase and tryptic esterase activities that are complexed to proteoglycans in the secretory granules of human cloned natural killer cells. J Immunol. 1989 Jan 15; 142(2):609-15.
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Rothenberg ME, Austen KF. Influence of the fibroblast environment on the structure of mast cell proteoglycans. Ann N Y Acad Sci. 1989; 556:233-44.
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Gurish MF, Austen KF. Different mast cell mediators produced by different mast cell phenotypes. Ciba Found Symp. 1989; 147:36-45; discussion 45-52.
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Soberman RJ, Austen KF. The cell biology and biochemistry of leukotriene C4 biosynthesis. Adv Prostaglandin Thromboxane Leukot Res. 1989; 19:21-5.
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Spragg J, Coblyn JS, Fraser PA, Austen KF, Weinblatt ME. The effect of cyclosporine on urinary kallikrein excretion in patients with rheumatoid arthritis. Adv Exp Med Biol. 1989; 247A:389-92.
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Sperling RI, Austen KF. Regulation of the 5-lipoxygenase pathway in human leucocytes. Br J Rheumatol. 1988 Dec; 27(6):469-76.
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Czop JK, Puglisi AV, Miorandi DZ, Austen KF. Perturbation of beta-glucan receptors on human neutrophils initiates phagocytosis and leukotriene B4 production. J Immunol. 1988 Nov 1; 141(9):3170-6.
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Janusz MJ, Austen KF, Czop JK. Phagocytosis of heat-killed blastospores of Candida albicans by human monocyte beta-glucan receptors. Immunology. 1988 Oct; 65(2):181-5.
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Rothenberg ME, Pomerantz JL, Owen WF, Avraham S, Soberman RJ, Austen KF, Stevens RL. Characterization of a human eosinophil proteoglycan, and augmentation of its biosynthesis and size by interleukin 3, interleukin 5, and granulocyte/macrophage colony stimulating factor. J Biol Chem. 1988 Sep 25; 263(27):13901-8.
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Reynolds DS, Serafin WE, Faller DV, Wall DA, Abbas AK, Dvorak AM, Austen KF, Stevens RL. Immortalization of murine connective tissue-type mast cells at multiple stages of their differentiation by coculture of splenocytes with fibroblasts that produce Kirsten sarcoma virus. J Biol Chem. 1988 Sep 5; 263(25):12783-91.
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Spragg J, Weinblatt ME, Coblyn J, Fraser P, Austen KF. Effect of cyclosporine on urinary kallikrein excretion in patients with rheumatoid arthritis. J Lab Clin Med. 1988 Sep; 112(3):324-32.
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Soberman RJ, Sutyak JP, Okita RT, Wendelborn DF, Roberts LJ, Austen KF. The identification and formation of 20-aldehyde leukotriene B4. J Biol Chem. 1988 Jun 15; 263(17):7996-8002.
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Rothenberg ME, Owen WF, Silberstein DS, Woods J, Soberman RJ, Austen KF, Stevens RL. Human eosinophils have prolonged survival, enhanced functional properties, and become hypodense when exposed to human interleukin 3. J Clin Invest. 1988 Jun; 81(6):1986-92.
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Stevens RL, Avraham S, Gartner MC, Bruns GA, Austen KF, Weis JH. Isolation and characterization of a cDNA that encodes the peptide core of the secretory granule proteoglycan of human promyelocytic leukemia HL-60 cells. J Biol Chem. 1988 May 25; 263(15):7287-91.
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Avraham S, Stevens RL, Gartner MC, Austen KF, Lalley PA, Weis JH. Isolation of a cDNA that encodes the peptide core of the secretory granule proteoglycan of rat basophilic leukemia-1 cells and assessment of its homology to the human analogue. J Biol Chem. 1988 May 25; 263(15):7292-6.
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Katz HR, Dayton ET, Levi-Schaffer F, Benson AC, Austen KF, Stevens RL. Coculture of mouse IL-3-dependent mast cells with 3T3 fibroblasts stimulates synthesis of globopentaosylceramide (Forssman glycolipid) by fibroblasts and surface expression on both populations. J Immunol. 1988 May 1; 140(9):3090-7.
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Stevens RL, Fox CC, Lichtenstein LM, Austen KF. Identification of chondroitin sulfate E proteoglycans and heparin proteoglycans in the secretory granules of human lung mast cells. Proc Natl Acad Sci U S A. 1988 Apr; 85(7):2284-7.
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Heavey DJ, Ernst PB, Stevens RL, Befus AD, Bienenstock J, Austen KF. Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells. J Immunol. 1988 Mar 15; 140(6):1953-7.
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Yoshimoto T, Soberman RJ, Spur B, Austen KF. Properties of highly purified leukotriene C4 synthase of guinea pig lung. J Clin Invest. 1988 Mar; 81(3):866-71.
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Dayton ET, Pharr P, Ogawa M, Serafin WE, Austen KF, Levi-Schaffer F, Stevens RL. 3T3 fibroblasts induce cloned interleukin 3-dependent mouse mast cells to resemble connective tissue mast cells in granular constituency. Proc Natl Acad Sci U S A. 1988 Jan; 85(2):569-72.
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Sperling RI, Robin JL, Kylander KA, Lee TH, Lewis RA, Austen KF. The effects of N-3 polyunsaturated fatty acids on the generation of platelet-activating factor-acether by human monocytes. J Immunol. 1987 Dec 15; 139(12):4186-91.
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Sheffer AL, Fearon DT, Austen KF. Hereditary angioedema: a decade of management with stanozolol. J Allergy Clin Immunol. 1987 Dec; 80(6):855-60.
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Serafin WE, Dayton ET, Gravallese PM, Austen KF, Stevens RL. Carboxypeptidase A in mouse mast cells. Identification, characterization, and use as a differentiation marker. J Immunol. 1987 Dec 1; 139(11):3771-6.
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Levi-Schaffer F, Dayton ET, Austen KF, Hein A, Caulfield JP, Gravallese PM, Liu FT, Stevens RL. Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. J Immunol. 1987 Nov 15; 139(10):3431-41.
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Drazen JM, Austen KF. Leukotrienes and airway responses. Am Rev Respir Dis. 1987 Oct; 136(4):985-98.
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Murphy GF, Austen KF, Fonferko E, Sheffer AL. Morphologically distinctive forms of cutaneous mast cell degranulation induced by cold and mechanical stimuli: an ultrastructural study. J Allergy Clin Immunol. 1987 Oct; 80(4):603-11.
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Trentham DE, Belli JA, Bloomer WD, Anderson RJ, Lane H, Reinherz EL, Austen KF. 2,000-centiGray total lymphoid irradiation for refractory rheumatoid arthritis. Arthritis Rheum. 1987 Sep; 30(9):980-7.
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Austen KF, Chau LY, Sun FF. Leukotriene C4 binding proteins and their implications. Adv Prostaglandin Thromboxane Leukot Res. 1987; 17A:12-9.
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Weinblatt ME, Coblyn JS, Fraser PA, Anderson RJ, Spragg J, Trentham DE, Austen KF. Cyclosporin A treatment of refractory rheumatoid arthritis. Arthritis Rheum. 1987 Jan; 30(1):11-7.
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Nicholson-Weller A, Russian DA, Austen KF. Natural killer cells are deficient in the surface expression of the complement regulatory protein, decay accelerating factor (DAF). J Immunol. 1986 Aug 15; 137(4):1275-9.
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Sperling RI, Lewis RA, Austen KF. Regulation of 5-lipoxygenase pathway product generation in human neutrophils by n-3 fatty acids. Prog Lipid Res. 1986; 25(1-4):101-4.
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MacDermott RP, Schmidt RE, Caulfield JP, Hein A, Bartley GT, Ritz J, Schlossman SF, Austen KF, Stevens RL. Proteoglycans in cell-mediated cytotoxicity. Identification, localization, and exocytosis of a chondroitin sulfate proteoglycan from human cloned natural killer cells during target cell lysis. J Exp Med. 1985 Dec 1; 162(6):1771-87.
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Schmidt RE, MacDermott RP, Bartley G, Bertovich M, Amato DA, Austen KF, Schlossman SF, Stevens RL, Ritz J. Specific release of proteoglycans from human natural killer cells during target lysis. Nature. 1985 Nov 21-27; 318(6043):289-91.
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Spragg J, Denney DL, Tilney NL, Austen KF. Kallikrein excretion in renal transplant recipients and in uninephrectomized donors. Kidney Int. 1985 Jul; 28(1):75-81.
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Nicholson-Weller A, March JP, Rosen CE, Spicer DB, Austen KF. Surface membrane expression by human blood leukocytes and platelets of decay-accelerating factor, a regulatory protein of the complement system. Blood. 1985 May; 65(5):1237-44.
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Nicholson-Weller A, Spicer DB, Austen KF. Deficiency of the complement regulatory protein, "decay-accelerating factor," on membranes of granulocytes, monocytes, and platelets in paroxysmal nocturnal hemoglobinuria. N Engl J Med. 1985 Apr 25; 312(17):1091-7.
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Trentham DE, Weinblatt ME, Austen KF. Total lymphoid irradiation in tertiary care for rheumatoid arthritis. Ann Intern Med. 1985 Apr; 102(4):544-5.
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Roberts WN, Wilson JG, Wong W, Jenkins DE, Fearon DT, Austen KF, Nicholson-Weller A. Normal function of CR1 on affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria. J Immunol. 1985 Jan; 134(1):512-7.
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DuBuske L, Austen KF, Czop J, Stevens RL. Granule-associated serine neutral proteases of the mouse bone marrow-derived mast cell that degrade fibronectin: their increase after sodium butyrate treatment of the cells. J Immunol. 1984 Sep; 133(3):1535-41.
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Hoover RL, Karnovsky MJ, Austen KF, Corey EJ, Lewis RA. Leukotriene B4 action on endothelium mediates augmented neutrophil/endothelial adhesion. Proc Natl Acad Sci U S A. 1984 Apr; 81(7):2191-3.
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Pinkus GS, Maier M, Seldin DC, ole-MoiYoi OK, Austen KF, Spragg J. Immunohistochemical localization of glandular kallikrein in the endocrine and exocrine human pancreas. J Histochem Cytochem. 1983 Nov; 31(11):1279-88.
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Maier M, Austen KF, Spragg J. Purification of single-chain human low-molecular-weight kininogen and demonstration of its cleavage by human urinary kallikrein. Anal Biochem. 1983 Oct 15; 134(2):336-46.
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Nicholson-Weller A, March JP, Rosenfeld SI, Austen KF. Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor. Proc Natl Acad Sci U S A. 1983 Aug; 80(16):5066-70.
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Maier M, Austen KF, Spragg J. Characterization of the procoagulant chain derived from human high molecular weight kininogen (Fitzgerald factor) by human tissue kallikrein. Blood. 1983 Aug; 62(2):457-63.
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Maier M, Austen KF, Spragg J. Kinetic analysis of the interaction of human tissue kallikrein with single-chain human high and low molecular weight kininogens. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):3928-32.
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Pinkus GS, Maier M, ole-MoiYoi OK, Austen KF, Spragg J. Kallikrein localization in human pancreas with three different antisera to human tissue kallikreins. Adv Exp Med Biol. 1983; 156:367-76.
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Nicholson-Weller A, Burge J, Fearon DT, Weller PF, Austen KF. Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system. J Immunol. 1982 Jul; 129(1):184-9.
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Weiss JW, Drazen JM, Coles N, McFadden ER, Weller PF, Corey EJ, Lewis RA, Austen KF. Bronchoconstrictor effects of leukotriene C in humans. Science. 1982 Apr 9; 216(4542):196-8.
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Moore FD, Austen KF, Fearon DT. Antibody restores human alternative complement pathway activation by mouse erythrocytes rendered functionally deficient by pretreatment with pronase. J Immunol. 1982 Mar; 128(3):1302-6.
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Dvorak AM, Mihm MC, Osage JE, Kwan TH, Austen KF, Wintroub BU. Bullous pemphigoid, an ultrastructural study of the inflammatory response: eosinophil, basophil and mast cell granule changes in multiple biopsies from one patient. J Invest Dermatol. 1982 Feb; 78(2):91-101.
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Stevens RL, Austen KF. Effect of p-nitrophenyl-beta-D-xyloside on proteoglycan and glycosaminoglycan biosynthesis in rat serosal mast cell cultures. J Biol Chem. 1982 Jan 10; 257(1):253-9.
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Weiss JW, Drazen JM, McFadden ER, Weller PF, Corey EJ, Lewis RA, Austen KF. Comparative bronchoconstrictor effects of histamine, leukotriene C, and leukotriene D in normal human volunteers. Trans Assoc Am Physicians. 1982; 95:30-5.
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Nicholson-Weller A, Burge J, Austen KF. Purification from guinea pig erythrocyte stroma of a decay-accelerating factor for the classical c3 convertase, C4b,2a. J Immunol. 1981 Nov; 127(5):2035-9.
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Spragg J, Pinkus GS, Ole-Moiyoi OK, Austen KF. The antigenic relationship of a contaminant of human urinary kallikrein to Tamm-Horsfall protein. J Histochem Cytochem. 1981 Sep; 29(9):1112-3.
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Moore FD, Fearon DT, Austen KF. IgG on mouse erythrocytes augments activation of the human alternative complement pathway by enhancing deposition of C3b. J Immunol. 1981 May; 126(5):1805-9.
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Nicholson-Weller A, Daha MR, Austen KF. Different functions for specific guinea pig IgG1 and IgG2 in the lysis of sheep erythrocytes by C4-deficient guinea pig serum. J Immunol. 1981 May; 126(5):1800-4.
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Pinkus GS, Ole-Moiyoi O, Austen KF, Spragg J. Antigenic separation of a nonkinin-generating TAMe esterase from human urinary kallikrein and immunohistochemical comparison of their localization in the kidney. J Histochem Cytochem. 1981 Jan; 29(1):38-44.
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Burge J, Nicholson-Weller A, Austen KF. Isolation of the fourth component of guinea pig complement and its single polypeptide chain precursor from plasma. Mol Immunol. 1981 Jan; 18(1):47-54.
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Stevens RL, Austen KF. Proteoglycans of the mast cell. Kroc Found Ser. 1981; 14:69-88.
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Burge J, Nicholson-Weller A, Austen KF. Isolation of C4-binding protein from guinea pig plasma and demonstration of its function as a control protein of the classical complement pathway C3 convertase. J Immunol. 1981 Jan; 126(1):232-5.
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Metcalfe DD, Smith JA, Austen KF, Silbert JE. Polydispersity of rat mast cell heparin. Implications for proteoglycan assembly. J Biol Chem. 1980 Dec 25; 255(24):11753-8.
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Ole-Moiyoi OK, Pinkus GS, Spragg J, Austen KF. On localization of kallikrein in the human pancreas and salivary glands by direct immunofluorescence. J Histochem Cytochem. 1980 Dec; 28(12):1359.
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Wintroub BU, Coblyn JS, Kaempfer CE, Austen KF. Cleavage of fibrinogen by the human neutrophil neutral peptide-generating protease. Proc Natl Acad Sci U S A. 1980 Sep; 77(9):5448-52.
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Austen KF. Chemical mediators originating from human mast cells: a commentary. Clin Allergy. 1980 Jul; 10 Suppl:477-9.
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Silver MR, ole-MoiYoi O, Austen KF, Spragg J. Active site radioimmunoassay for human urokallikrein and demonstration by radioimmunoassay of a latent form of the enzyme. J Immunol. 1980 Apr; 124(4):1551-5.
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Metcalfe DD, Lewis RA, Silbert JE, Rosenberg RD, Wasserman SI, Austen KF. Isolation and characterization of heparin from human lung. J Clin Invest. 1979 Dec; 64(6):1537-43.
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Kazatchkine MD, Fearon DT, Silbert JE, Austen KF. Surface-associated heparin inhibits zymosan-induced activation of the human alternative complement pathway by augmenting the regulatory action of the control proteins on particle-bound C3b. J Exp Med. 1979 Nov 1; 150(5):1202-15.
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Levinsky NG, ole-MoiYoi OK, Austen KF, Spragg J. Measurement of human urinary kallikrein and evidence for non-kallikrein urinary TAMe esterases by direct immunoassay and by affinity chromatography. Biochem Pharmacol. 1979 Aug 15; 28(16):2491-5.
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Yoi OO, Seldin DC, Spragg J, Pinkus GS, Austen KF. Sequential cleavage of proinsulin by human pancreatic kallikrein and a human pancreatic kininase. Proc Natl Acad Sci U S A. 1979 Aug; 76(8):3612-6.
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ole-MoiYoi OK, Spragg J, Austen KF. Structural studies of human urinary kallikrein (urokallikrein). Proc Natl Acad Sci U S A. 1979 Jul; 76(7):3121-5.
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ole-MoiYoi OK, Pinkus GS, Spragg J, Austen KF. Identification of human glandular kallikrein in the beta cell of the pancreas. N Engl J Med. 1979 Jun 7; 300(23):1289-94.
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Coblyn JS, Austen KF, Wintroub BU. Purification and characterization of a human neutrophil neutral protease. The neutral peptide-generating protease. J Clin Invest. 1979 May; 63(5):998-1005.
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Binder BR, Spragg J, Austen KF. Purification and characterization of human vascular plasminogen activator derived from blood vessel perfusates. J Biol Chem. 1979 Mar 25; 254(6):1998-2003.
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ole-MoiYoi OK, Spragg J, Austen KF. Inhibition of human urinary kallikrein (urokallikrein) by anti-enzyme FAB. J Immunol. 1978 Jul; 121(1):66-71.
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Yoi OO, Austen KF, Spragg J. Kinin-generating and esterolytic activity of purified human urinary kallikrein (urokallikrein). Biochem Pharmacol. 1977 Oct 15; 26(20):1893-1900.
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Yurt RW, Leid RW, Spragg J, Austen KF. Immunologic release of heparin from purified rat peritoneal mast cells. J Immunol. 1977 Apr; 118(4):1201-7.
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Fearon DT, Daha MR, Strom TB, Weiler JM, Carpenter CB, Austen KF. Pathways of complement activation in membranoproliferative glomerulonephritis and allograft rejection. Transplant Proc. 1977 Mar; 9(1):729-39.
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ole-Moi Yoi O, Spragg J, Halbert SP, Austen KF. Immunologic reactivity of purified human urinary kallikrein (urokallikrein) with antiserum directed against human pancreas. J Immunol. 1977 Feb; 118(2):667-72.
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Rynes RI, Ruddy S, Spragg J, Stillman JS, Austen KF. Intraarticular activation of the complement system in patients with juvenile rheumatoid arthritis. Arthritis Rheum. 1976 Mar-Apr; 19(2):161-8.
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Magoon EH, Austen KF, Spragg J. Immunoelectrophoretic analysis and radial immunodiffusion assay using plasminogen purified from fresh human plasma. Clin Exp Immunol. 1974 Jun; 17(2):345-59.
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Spragg J, Austen KF. Preparation of human kininogen. 3. Enzymatic digestion and modification. Biochem Pharmacol. 1974 Feb 15; 23(4):781-91.
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Goetzl EJ, Austen KF. Stimulation of human neutrophil leukocyte aerobic glucose metabolism by purified chemotactic factors. J Clin Invest. 1974 Feb; 53(2):591-9.
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Strom TB, Carpenter CB, Garovoy MR, Austen KF, Merrill JP, Kaliner M. The modulating influence of cyclic nucleotides upon lymphocyte-mediated cytotoxicity. J Exp Med. 1973 Aug 1; 138(2):381-93.
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Spragg J, Kaplan AP, Austen KF. The use of isoelectric focusing to study components of the human plasma kinin-forming system. Ann N Y Acad Sci. 1973 Jun 15; 209:372-86.
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Spragg J, Austen KF. the preparation of human kininogen. II. Further characterization of purified human kininogen. J Immunol. 1971 Dec; 107(6):1512-9.
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Orange RP, Austen WG, Austen KF. Immunological release of histamine and slow-reacting substance of anaphylaxis from human lung : I. Modulation by agents influencing cellular levels of cyclic 3',5'-adenosine monophosphate. J Exp Med. 1971 Sep 1; 134(3):136-48.
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Ruddy S, Everson LK, Schur PH, Austen KF. Hemolytic assay of the ninth complement component: elevation and depletion in rheumatic diseases. J Exp Med. 1971 Sep 1; 134(3):259-75.
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Spragg J, Haber E, Austen KF. The preparation of human kininogen and the elicitation of antibody for use in a radial immuno-diffusion assay. J Immunol. 1970 Jun; 104(6):1348-54.
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Fischer J, Spragg J, Talamo RC, Pierce JV, Suzuki K, Austen KF, Haber E. Structural requirements for binding of bradykinin to antibody. 3. The effect of carrier on antibody specificity. Biochemistry. 1969 Sep; 8(9):3750-7.
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Spragg J, Talamo RC, Suzuki K, Appelbaum DM, Austen KF, Haber E. Structural requirements for binding of bradykinin to antibody. II. Studies with bradykinin fragments. Biochemistry. 1968 Nov; 7(11):4086-9.
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Spragg J, Schröder E, Stewart JM, Austen KF, Haber E. Structural requirements for binding to antibody of sequence variants of bradykinin. Biochemistry. 1967 Dec; 6(12):3933-41.
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Spragg J, Austen KF, Haber E. Production of antibody against bradykinin: demonstration of specificity by complement fixation and radio-immunoassay. J Immunol. 1966 May; 96(5):865-71.
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GUINEY EJ, AUSTEN KF, RUSSELL PS. MEASUREMENT OF SERUM COMPLEMENT DURING HOMOGRAFT REJECTION IN MAN AND RAT. Proc Soc Exp Biol Med. 1964 Apr; 115:1113-7.
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