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George Francis Murphy, M.D.

TitleProfessor of Pathology
InstitutionBrigham and Women's Hospital
DepartmentPathology
AddressBrigham and Women's Hospital
Dermatopathology
75 Francis St
Boston MA 02115
Phone617/525-7485
Fax617/264-5149

 Biography 
 awards and honors
1976 - Induction
1976 - Sheard-Sanford Award (Honorable Men.)
1976 - Woodbury Alumni Award, Medicine
1982 - Election
1984 - Benjamin Castleman Award
1987 - John Morgan Society
1987 - Long Course Director, Service Award
1988 - Arthur K. Doolittle Award
1988 - 1989Diagnostic Pathology Faculty
1988 - Election
1988 - Leaders' Society
1991 - Election to Organization
1991 - Herman Beerman Endowed Chair
1992 - Teaching Award, Class of 1995
1992 - Whitaker Health Sciences Foundation Award
1993 - Attending Teaching Award, Dermatology
1993 - Merlin Trumbull Lectureship
1994 - Keynote Address
1994 - 1998Short Course Faculty
1995 - Faculty Teaching Award, Class of 1995
1997 - Chair, Board of Directors
1997 - Institutional Representative
1997 - U.S. Delegate
1998 - Schleifstein Lectureship
1999 - Keynote Address
1999 - Quest Visiting Professorship in Pathology
2000 - Proctor&Gamble Lectureship
2001 - Expert Advisory Panel on Skin Tumors
2005 - Honorary Master of Arts Degree
2006 - Distinguished Academic Achievement Award
2007 - Walter Putchar Annual Lectureship

 Overview 
 overview
Dr. Murphy’s program in funded basic investigation has been ongoing continuously since 1984 in the form of R01 grants and via participation in Program Project initiatives. The current focus of Dr. Murphy's research is elucidation of the cellular and molecular mechanisms responsible for cutaneous cytotoxic reactions, including graft-versus-host disease subsequent to allogeneic stem cell transplantation for childhood and adult leukemia/lymphoma. In addition, a major collaboration involving Brigham Plastic and Reconstructive Surgery and the MIT Biomaterials Department focuses on tissue stem cell biology and cutaneous regenerative medicine. One goal of this work is to define pathways responsible for scarless regeneration that typifies fetal, but not post-natal, human skin. Dr. Murphy also serves as the Director of the Tissue and Cell Analysis Core for the Harvard Skin Disease Research Center (SDRC) as well as for the Biospecimen Access and Analysis Core for the Harvard Specialized Program for Research Excellence (SPORE) in skin cancer. For research contributions concerning Langerhans cell histiocytosis, he received the Benjamin Castleman Award of the International Academy of Pathology. In 1991, he was elected into the American Society for Clinical Investigation for which he also served as an Institutional Representative. His work in the area of neuropeptide regulation of Langerhans cell function was recognized as one of the 50 most significant scientific breakthroughs worldwide for the year 1993 by the magazine, Discover. His most recent collaborative interaction with the laboratory of Dr. Markus Frank of Boston’s Children’s Hospital has recently fostered the first biomarker identification and therapeutically relevant targeting of melanoma stem cells (January 2008 cover article, Nature). He has served as a regular term member of the General Medicine A Study Section for the NIH.


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kao HK, Li Q, Flynn B, Qiao X, Ruberti JW, Murphy GF, Guo L. Collagen synthesis modulated in wounds treated by pulsed radiofrequency energy. Plast Reconstr Surg. 2013 Apr; 131(4):490e-8e.
    View in: PubMed
  2. Frederick DT, Piris A, Cogdill AP, Cooper ZA, Lezcano C, Ferrone CR, Mitra D, Boni A, Newton LP, Liu C, Peng W, Sullivan RJ, Lawrence DP, Hodi FS, Overwijk WW, Lizée G, Murphy GF, Hwu P, Flaherty KT, Fisher DE, Wargo JA. BRAF Inhibition Is Associated with Enhanced Melanoma Antigen Expression and a More Favorable Tumor Microenvironment in Patients with Metastatic Melanoma. Clin Cancer Res. 2013 Mar 1; 19(5):1225-31.
    View in: PubMed
  3. Oyoshi MK, He R, Li Y, Mondal S, Yoon J, Afshar R, Chen M, Lee DM, Luo HR, Luster AD, Cho JS, Miller LS, Larson A, Murphy GF, Geha RS. Leukotriene b4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 2012 Oct 19; 37(4):747-58.
    View in: PubMed
  4. Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YG. Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma. Cell. 2012 Sep 14; 150(6):1135-46.
    View in: PubMed
  5. Hanash AM, Dudakov JA, Hua G, O'Connor MH, Young LF, Singer NV, West ML, Jenq RR, Holland AM, Kappel LW, Ghosh A, Tsai JJ, Rao UK, Yim NL, Smith OM, Velardi E, Hawryluk EB, Murphy GF, Liu C, Fouser LA, Kolesnick R, Blazar BR, van den Brink MR. Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease. Immunity. 2012 Aug 24; 37(2):339-50.
    View in: PubMed
  6. Velez NF, Ishizawar RC, Dellaripa PF, Saavedra AP, Laga AC, Murphy GF, Fisher DC, Kupper TS, Vleugels RA. Full facial edema: a novel presentation of subcutaneous panniculitis-like T-cell lymphoma. J Clin Oncol. 2012 Sep 1; 30(25):e233-6.
    View in: PubMed
  7. Gropper AB, Girouard SD, Hojman LP, Huang SJ, Qian X, Murphy GF, Vleugels RA. Metastatic basal cell carcinoma of the posterior neck: case report and review of the literature. J Cutan Pathol. 2012 May; 39(5):526-34.
    View in: PubMed
  8. Ogembo JG, Milner DA, Mansfield KG, Rodig SJ, Murphy GF, Kutok JL, Pinkus GS, Fingeroth JD. SIRPa/CD172a and FHOD1 are unique markers of littoral cells, a recently evolved major cell population of red pulp of human spleen. J Immunol. 2012 May 1; 188(9):4496-505.
    View in: PubMed
  9. Zhan Q, Korngold R, Lezcano C, McKeon F, Murphy GF. Graft-versus-host disease-related cytokine-driven apoptosis depends on p73 in cytokeratin 15-positive target cells. Biol Blood Marrow Transplant. 2012 Jun; 18(6):841-51.
    View in: PubMed
  10. Tian T, Dubin K, Jin Q, Qureshi A, King SL, Liu L, Jiang X, Murphy GF, Kupper TS, Fuhlbrigge RC. Disruption of TNF-a/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection. J Invest Dermatol. 2012 May; 132(5):1425-34.
    View in: PubMed
  11. Girouard SD, Laga AC, Mihm MC, Scolyer RA, Thompson JF, Zhan Q, Widlund HR, Lee CW, Murphy GF. SOX2 contributes to melanoma cell invasion. Lab Invest. 2012 Mar; 92(3):362-70.
    View in: PubMed
  12. Cedeno-Laurent F, Opperman MJ, Barthel SR, Hays D, Schatton T, Zhan Q, He X, Matta KL, Supko JG, Frank MH, Murphy GF, Dimitroff CJ. Metabolic inhibition of galectin-1-binding carbohydrates accentuates antitumor immunity. J Invest Dermatol. 2012 Feb; 132(2):410-20.
    View in: PubMed
  13. Kao HK, Chen B, Murphy GF, Li Q, Orgill DP, Guo L. Peripheral blood fibrocytes: enhancement of wound healing by cell proliferation, re-epithelialization, contraction, and angiogenesis. Ann Surg. 2011 Dec; 254(6):1066-74.
    View in: PubMed
  14. Peng C, Chen B, Kao HK, Murphy G, Orgill DP, Guo L. Lack of FGF-7 further delays cutaneous wound healing in diabetic mice. Plast Reconstr Surg. 2011 Dec; 128(6):673e-84e.
    View in: PubMed
  15. Zhou J, Yuen NK, Zhan Q, Velazquez EF, Murphy GF, Giobbie-Hurder A, Hodi FS. Immunity to the melanoma inhibitor of apoptosis protein (ML-IAP; livin) in patients with malignant melanoma. Cancer Immunol Immunother. 2012 May; 61(5):655-65.
    View in: PubMed
  16. Lu SX, Kappel LW, Charbonneau-Allard AM, Atallah R, Holland AM, Turbide C, Hubbard VM, Rotolo JA, Smith M, Suh D, King C, Rao UK, Yim N, Bautista JL, Jenq RR, Penack O, Na IK, Liu C, Murphy G, Alpdogan O, Blumberg RS, Macian F, Holmes KV, Beauchemin N, van den Brink MR. Ceacam1 separates graft-versus-host-disease from graft-versus-tumor activity after experimental allogeneic bone marrow transplantation. PLoS One. 2011; 6(7):e21611.
    View in: PubMed
  17. Wilson BJ, Schatton T, Zhan Q, Gasser M, Ma J, Saab KR, Schanche R, Waaga-Gasser AM, Gold JS, Huang Q, Murphy GF, Frank MH, Frank NY. ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients. Cancer Res. 2011 Aug 1; 71(15):5307-16.
    View in: PubMed
  18. Li Q, Kao H, Matros E, Peng C, Murphy GF, Guo L. Pulsed radiofrequency energy accelerates wound healing in diabetic mice. Plast Reconstr Surg. 2011 Jun; 127(6):2255-62.
    View in: PubMed
  19. Hanash AM, Kappel LW, Yim NL, Nejat RA, Goldberg GL, Smith OM, Rao UK, Dykstra L, Na IK, Holland AM, Dudakov JA, Liu C, Murphy GF, Leonard WJ, Heller G, van den Brink MR. Abrogation of donor T-cell IL-21 signaling leads to tissue-specific modulation of immunity and separation of GVHD from GVL. Blood. 2011 Jul 14; 118(2):446-55.
    View in: PubMed
  20. Goldberg BB, Merton DA, Liu JB, Forsberg F, Zhang K, Thakur M, Schulz S, Schanche R, Murphy GF, Waldman SA. Contrast-enhanced ultrasound imaging of sentinel lymph nodes after peritumoral administration of Sonazoid in a melanoma tumor animal model. J Ultrasound Med. 2011 Apr; 30(4):441-53.
    View in: PubMed
  21. Laga AC, Zhan Q, Weishaupt C, Ma J, Frank MH, Murphy GF. SOX2 and nestin expression in human melanoma: an immunohistochemical and experimental study. Exp Dermatol. 2011 Apr; 20(4):339-45.
    View in: PubMed
  22. Girouard SD, Murphy GF. Melanoma stem cells: not rare, but well done. Lab Invest. 2011 May; 91(5):647-64.
    View in: PubMed
  23. Lu F, Ogawa R, Nguyen DT, Chen B, Guo D, Helm DL, Zhan Q, Murphy GF, Orgill DP. Microdeformation of three-dimensional cultured fibroblasts induces gene expression and morphological changes. Ann Plast Surg. 2011 Mar; 66(3):296-300.
    View in: PubMed
  24. Erba P, Ogawa R, Ackermann M, Adini A, Miele LF, Dastouri P, Helm D, Mentzer SJ, D'Amato RJ, Murphy GF, Konerding MA, Orgill DP. Angiogenesis in wounds treated by microdeformational wound therapy. Ann Surg. 2011 Feb; 253(2):402-9.
    View in: PubMed
  25. Purwar R, Campbell J, Murphy G, Richards WG, Clark RA, Kupper TS. Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. PLoS One. 2011; 6(1):e16245.
    View in: PubMed
  26. Frank NY, Schatton T, Kim S, Zhan Q, Wilson BJ, Ma J, Saab KR, Osherov V, Widlund HR, Gasser M, Waaga-Gasser AM, Kupper TS, Murphy GF, Frank MH. VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res. 2011 Feb 15; 71(4):1474-85.
    View in: PubMed
  27. Volpicelli ER, Doyle L, Annes JP, Murray MF, Jacobsen E, Murphy GF, Saavedra AP. Erdheim-Chester disease presenting with cutaneous involvement: a case report and literature review. J Cutan Pathol. 2011 Mar; 38(3):280-5.
    View in: PubMed
  28. Laga AC, Murphy GF. Cellular heterogeneity in vertical growth phase melanoma. Arch Pathol Lab Med. 2010 Dec; 134(12):1750-7.
    View in: PubMed
  29. Yu W, Liu J, Shi MA, Wang J, Xiang M, Kitamoto S, Wang B, Sukhova GK, Murphy GF, Orasanu G, Grubb A, Shi GP. Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice. PLoS One. 2010; 5(11):e13973.
    View in: PubMed
  30. Ma J, Lin JY, Alloo A, Wilson BJ, Schatton T, Zhan Q, Murphy GF, Waaga-Gasser AM, Gasser M, Stephen Hodi F, Frank NY, Frank MH. Isolation of tumorigenic circulating melanoma cells. Biochem Biophys Res Commun. 2010 Nov 26; 402(4):711-7.
    View in: PubMed
  31. Lu SX, Holland AM, Na IK, Terwey TH, Alpdogan O, Bautista JL, Smith OM, Suh D, King C, Kochman A, Hubbard VM, Rao UK, Yim N, Liu C, Laga AC, Murphy G, Jenq RR, Zakrzewski JL, Penack O, Dykstra L, Bampoe K, Perez L, Furie B, Furie B, van den Brink MR. Absence of P-selectin in recipients of allogeneic bone marrow transplantation ameliorates experimental graft-versus-host disease. J Immunol. 2010 Aug 1; 185(3):1912-9.
    View in: PubMed
  32. Song G, Nguyen DT, Pietramaggiori G, Scherer S, Chen B, Zhan Q, Ogawa R, Yannas IV, Wagers AJ, Orgill DP, Murphy GF. Use of the parabiotic model in studies of cutaneous wound healing to define the participation of circulating cells. Wound Repair Regen. 2010 Jul-Aug; 18(4):426-32.
    View in: PubMed
  33. Penack O, Henke E, Suh D, King CG, Smith OM, Na IK, Holland AM, Ghosh A, Lu SX, Jenq RR, Liu C, Murphy GF, Lu TT, May C, Scheinberg DA, Gao DC, Mittal V, Heller G, Benezra R, van den Brink MR. Inhibition of neovascularization to simultaneously ameliorate graft-vs-host disease and decrease tumor growth. J Natl Cancer Inst. 2010 Jun 16; 102(12):894-908.
    View in: PubMed
  34. Murphy GF. A Festschrift for Martin C. Mihm, Jr. J Cutan Pathol. 2010 Apr; 37 Suppl 1:1-5.
    View in: PubMed
  35. McAllister JC, Zhan Q, Weishaupt C, Hsu MY, Murphy GF. The embryonic morphogen, Nodal, is associated with channel-like structures in human malignant melanoma xenografts. J Cutan Pathol. 2010 Apr; 37 Suppl 1:19-25.
    View in: PubMed
  36. Schatton T, Schütte U, Frank NY, Zhan Q, Hoerning A, Robles SC, Zhou J, Hodi FS, Spagnoli GC, Murphy GF, Frank MH. Modulation of T-cell activation by malignant melanoma initiating cells. Cancer Res. 2010 Jan 15; 70(2):697-708.
    View in: PubMed
  37. Laga AC, Lai CY, Zhan Q, Huang SJ, Velazquez EF, Yang Q, Hsu MY, Murphy GF. Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology. Am J Pathol. 2010 Feb; 176(2):903-13.
    View in: PubMed
  38. Ogawa R, Mizuno S, Murphy GF, Orgill DP. The effect of hydrostatic pressure on three-dimensional chondroinduction of human adipose-derived stem cells. Tissue Eng Part A. 2009 Oct; 15(10):2937-45.
    View in: PubMed
  39. Martin JE, Wagner AJ, Murphy GF, Pinkus GS, Wang LC. Granuloma annulare heralding angioimmunoblastic T-cell lymphoma in a patient with a history of epstein-barr virus-associated B-cell lymphoma. J Clin Oncol. 2009 Nov 1; 27(31):e168-71.
    View in: PubMed
  40. Penack O, Smith OM, Cunningham-Bussel A, Liu X, Rao U, Yim N, Na IK, Holland AM, Ghosh A, Lu SX, Jenq RR, Liu C, Murphy GF, Brandl K, van den Brink MR. NOD2 regulates hematopoietic cell function during graft-versus-host disease. J Exp Med. 2009 Sep 28; 206(10):2101-10.
    View in: PubMed
  41. Oyoshi MK, Elkhal A, Kumar L, Scott JE, Koduru S, He R, Leung DY, Howell MD, Oettgen HC, Murphy GF, Geha RS. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc Natl Acad Sci U S A. 2009 Sep 1; 106(35):14954-9.
    View in: PubMed
  42. Oyoshi MK, Murphy GF, Geha RS. Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. J Allergy Clin Immunol. 2009 Sep; 124(3):485-93, 493.e1.
    View in: PubMed
  43. Rotolo JA, Stancevic B, Lu SX, Zhang J, Suh D, King CG, Kappel LW, Murphy GF, Liu C, Fuks Z, van den Brink MR, Kolesnick R. Cytolytic T cells induce ceramide-rich platforms in target cell membranes to initiate graft-versus-host disease. Blood. 2009 Oct 22; 114(17):3693-706.
    View in: PubMed
  44. Huang SJ, Hijnen D, Murphy GF, Kupper TS, Calarese AW, Mollet IG, Schanbacher CF, Miller DM, Schmults CD, Clark RA. Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol. 2009 Nov; 129(11):2676-85.
    View in: PubMed
  45. Laga AC, Murphy GF. The translational basis of human cutaneous photoaging: on models, methods, and meaning. Am J Pathol. 2009 Feb; 174(2):357-60.
    View in: PubMed
  46. Clark RA, Huang SJ, Murphy GF, Mollet IG, Hijnen D, Muthukuru M, Schanbacher CF, Edwards V, Miller DM, Kim JE, Lambert J, Kupper TS. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med. 2008 Sep 29; 205(10):2221-34.
    View in: PubMed
  47. Tian T, Liu L, Freyschmidt EJ, Murphy GF, Kupper TS, Fuhlbrigge RC. Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus. J Invest Dermatol. 2009 Jan; 129(1):70-8.
    View in: PubMed
  48. Hsu MY, Rovinsky SA, Lai CY, Qasem S, Liu X, How J, Engelhardt JF, Murphy GF. Aggressive melanoma cells escape from BMP7-mediated autocrine growth inhibition through coordinated Noggin upregulation. Lab Invest. 2008 Aug; 88(8):842-55.
    View in: PubMed
  49. Rothberg BE, Moeder CB, Kluger H, Halaban R, Elder DE, Murphy GF, Lazar A, Prieto V, Duncan LM, Rimm DL. Nuclear to non-nuclear Pmel17/gp100 expression (HMB45 staining) as a discriminator between benign and malignant melanocytic lesions. Mod Pathol. 2008 Sep; 21(9):1121-9.
    View in: PubMed
  50. Hu S, Cohen D, Murphy G, Mody E, Qureshi AA. Interstitial granulomatous dermatitis in a patient with rheumatoid arthritis on etanercept. Cutis. 2008 Apr; 81(4):336-8.
    View in: PubMed
  51. Gleason BC, Crum CP, Murphy GF. Expression patterns of MITF during human cutaneous embryogenesis: evidence for bulge epithelial expression and persistence of dermal melanoblasts. J Cutan Pathol. 2008 Jul; 35(7):615-22.
    View in: PubMed
  52. Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH. Identification of cells initiating human melanomas. Nature. 2008 Jan 17; 451(7176):345-9.
    View in: PubMed
  53. Kim TD, Terwey TH, Zakrzewski JL, Suh D, Kochman AA, Chen ME, King CG, Borsotti C, Grubin J, Smith OM, Heller G, Liu C, Murphy GF, Alpdogan O, van den Brink MR. Organ-derived dendritic cells have differential effects on alloreactive T cells. Blood. 2008 Mar 1; 111(5):2929-40.
    View in: PubMed
  54. Murphy GF. Target cells in graft-versus-host disease: implications for cancer therapy. Clin Rev Allergy Immunol. 2007 Oct; 33(1-2):113-23.
    View in: PubMed
  55. Ramirez-Montagut T, Chow A, Kochman AA, Smith OM, Suh D, Sindhi H, Lu S, Borsotti C, Grubin J, Patel N, Terwey TH, Kim TD, Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MR. IFN-gamma and Fas ligand are required for graft-versus-tumor activity against renal cell carcinoma in the absence of lethal graft-versus-host disease. J Immunol. 2007 Aug 1; 179(3):1669-80.
    View in: PubMed
  56. DiRienzo CG, Murphy GF, Friedman TM, Korngold R. T-cell receptor V(alpha) usage by effector CD4+Vbeta11+ T cells mediating graft-versus-host disease directed to minor histocompatibility antigens. Biol Blood Marrow Transplant. 2007 Mar; 13(3):265-76.
    View in: PubMed
  57. Zhan Q, Signoretti S, Whitaker-Menezes D, Friedman TM, Korngold R, Murphy GF. Cytokeratin15-positive basal epithelial cells targeted in graft-versus-host disease express a constitutive antiapoptotic phenotype. J Invest Dermatol. 2007 Jan; 127(1):106-15.
    View in: PubMed
  58. Frank NY, Kho AT, Schatton T, Murphy GF, Molloy MJ, Zhan Q, Ramoni MF, Frank MH, Kohane IS, Gussoni E. Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J Cell Biol. 2006 Oct 9; 175(1):99-110.
    View in: PubMed
  59. Durakovic N, Bezak KB, Skarica M, Radojcic V, Fuchs EJ, Murphy GF, Luznik L. Host-derived Langerhans cells persist after MHC-matched allografting independent of donor T cells and critically influence the alloresponses mediated by donor lymphocyte infusions. J Immunol. 2006 Oct 1; 177(7):4414-25.
    View in: PubMed
  60. DiRienzo CG, Murphy GF, Jones SC, Korngold R, Friedman TM. T-cell receptor Valpha spectratype analysis of a CD4-mediated T-cell response against minor histocompatibility antigens involved in severe graft-versus-host disease. Biol Blood Marrow Transplant. 2006 Aug; 12(8):818-27.
    View in: PubMed
  61. Clark RA, Chong BF, Mirchandani N, Yamanaka K, Murphy GF, Dowgiert RK, Kupper TS. A novel method for the isolation of skin resident T cells from normal and diseased human skin. J Invest Dermatol. 2006 May; 126(5):1059-70.
    View in: PubMed
  62. Waldman E, Lu SX, Hubbard VM, Kochman AA, Eng JM, Terwey TH, Muriglan SJ, Kim TD, Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MR. Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestine. Blood. 2006 Feb 15; 107(4):1703-11.
    View in: PubMed
  63. Terwey TH, Kim TD, Kochman AA, Hubbard VM, Lu S, Zakrzewski JL, Ramirez-Montagut T, Eng JM, Muriglan SJ, Heller G, Murphy GF, Liu C, Budak-Alpdogan T, Alpdogan O, van den Brink MR. CCR2 is required for CD8-induced graft-versus-host disease. Blood. 2005 Nov 1; 106(9):3322-30.
    View in: PubMed
  64. Goldberg BB, Merton DA, Liu JB, Murphy G, Forsberg F. Contrast-enhanced sonographic imaging of lymphatic channels and sentinel lymph nodes. J Ultrasound Med. 2005 Jul; 24(7):953-65.
    View in: PubMed
  65. Hubbard VM, Eng JM, Ramirez-Montagut T, Tjoe KH, Muriglan SJ, Kochman AA, Terwey TH, Willis LM, Schiro R, Heller G, Murphy GF, Liu C, Alpdogan O, van den Brink MR. Absence of inducible costimulator on alloreactive T cells reduces graft versus host disease and induces Th2 deviation. Blood. 2005 Nov 1; 106(9):3285-92.
    View in: PubMed
  66. Lin TP, Pan CC, Huang WJ, Murphy GF. Primary sweat gland carcinosarcoma of the scrotal skin. J Cutan Pathol. 2004 Nov; 31(10):678-82.
    View in: PubMed
  67. Choksi S, Kim JC, Whitaker-Menezes D, Murphy GF, Friedman TM, Korngold R. A CD8 DE loop peptide analog prevents graft-versus-host disease in a multiple minor histocompatibility antigen-mismatched bone marrow transplantation model. Biol Blood Marrow Transplant. 2004 Oct; 10(10):669-80.
    View in: PubMed
  68. Sugerman PB, Faber SB, Willis LM, Petrovic A, Murphy GF, Pappo J, Silberstein D, van den Brink MR. Kinetics of gene expression in murine cutaneous graft-versus-host disease. Am J Pathol. 2004 Jun; 164(6):2189-202.
    View in: PubMed
  69. Murphy GF, Korngold R. Significance of selectively targeted apoptotic rete cells in graft-versus-host disease. Biol Blood Marrow Transplant. 2004 Jun; 10(6):357-65.
    View in: PubMed
  70. Friedman TM, Jones SC, Statton D, Murphy GF, Korngold R. Evolution of responding CD4+ and CD8+ T-cell repertoires during the development of graft-versus-host disease directed to minor histocompatibility antigens. Biol Blood Marrow Transplant. 2004 Apr; 10(4):224-35.
    View in: PubMed
  71. Goldberg BB, Merton DA, Liu JB, Thakur M, Murphy GF, Needleman L, Tornes A, Forsberg F. Sentinel lymph nodes in a swine model with melanoma: contrast-enhanced lymphatic US. Radiology. 2004 Mar; 230(3):727-34.
    View in: PubMed
  72. Jones SC, Friedman TM, Murphy GF, Korngold R. Specific donor Vbeta-associated CD4 T-cell responses correlate with severe acute graft-versus-host disease directed to multiple minor histocompatibility antigens. Biol Blood Marrow Transplant. 2004 Feb; 10(2):91-105.
    View in: PubMed
  73. Jones SC, Murphy GF, Friedman TM, Korngold R. Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell-mediated graft-versus-host disease model. J Clin Invest. 2003 Dec; 112(12):1880-6.
    View in: PubMed
  74. Deguchi M, Whitaker-Menezes D, Jones SC, Aiba S, Nakagawa S, Tagami H, Korngold R, Murphy GF. 12E2: a cloned murine dermal cell with features of dermal dendrocytes and capacity to produce pathologic changes resembling early Kaposi's sarcoma. Am J Pathol. 2003 Nov; 163(5):1817-25.
    View in: PubMed
  75. Jacobs MA, Kocher W, Murphy GF. Combined folliculotropic/syringotropic cutaneous T-cell lymphoma without epidermal involvement: report of 2 cases and pathogenic implications. Hum Pathol. 2003 Nov; 34(11):1216-20.
    View in: PubMed
  76. Whitaker-Menezes D, Jones SC, Friedman TM, Korngold R, Murphy GF. An epithelial target site in experimental graft-versus-host disease and cytokine-mediated cytotoxicity is defined by cytokeratin 15 expression. Biol Blood Marrow Transplant. 2003 Sep; 9(9):559-70.
    View in: PubMed
  77. Murphy GF. The skin biopsy and cutaneous medicine: why biopsy the obvious? Skinmed. 2003 Jul-Aug; 2(4):248-50.
    View in: PubMed
  78. Ding W, Beissert S, Deng L, Miranda E, Cassetty C, Seiffert K, Campton KL, Yan Z, Murphy GF, Bluestone JA, Granstein RD. Altered cutaneous immune parameters in transgenic mice overexpressing viral IL-10 in the epidermis. J Clin Invest. 2003 Jun; 111(12):1923-31.
    View in: PubMed
  79. Korngold R, Marini JC, de Baca ME, Murphy GF, Giles-Komar J. Role of tumor necrosis factor-alpha in graft-versus-host disease and graft-versus-leukemia responses. Biol Blood Marrow Transplant. 2003 May; 9(5):292-303.
    View in: PubMed
  80. Jones SC, Murphy GF, Korngold R. Post-hematopoietic cell transplantation control of graft-versus-host disease by donor CD425 T cells to allow an effective graft-versus-leukemia response. Biol Blood Marrow Transplant. 2003 Apr; 9(4):243-56.
    View in: PubMed
  81. Schmaltz C, Alpdogan O, Kappel BJ, Muriglan SJ, Rotolo JA, Ongchin J, Willis LM, Greenberg AS, Eng JM, Crawford JM, Murphy GF, Yagita H, Walczak H, Peschon JJ, van den Brink MR. T cells require TRAIL for optimal graft-versus-tumor activity. Nat Med. 2002 Dec; 8(12):1433-7.
    View in: PubMed
  82. Schmaltz C, Alpdogan O, Muriglan SJ, Kappel BJ, Rotolo JA, Ricchetti ET, Greenberg AS, Willis LM, Murphy GF, Crawford JM, van den Brink MR. Donor T cell-derived TNF is required for graft-versus-host disease and graft-versus-tumor activity after bone marrow transplantation. Blood. 2003 Mar 15; 101(6):2440-5.
    View in: PubMed
  83. Burkert KL, Huhn K, Menezes DW, Murphy GF. Langerhans cell microgranulomas (pseudo-pautrier abscesses): morphologic diversity, diagnostic implications and pathogenetic mechanisms. J Cutan Pathol. 2002 Oct; 29(9):511-6.
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  84. Kim JC, Whitaker-Menezes D, Deguchi M, Adair BS, Korngold R, Murphy GF. Novel expression of vascular cell adhesion molecule-1 (CD106) by squamous epithelium in experimental acute graft-versus-host disease. Am J Pathol. 2002 Sep; 161(3):763-70.
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  85. Murphy GF. Mechanism of apoptotic regulation of follicular regression: toward understanding the molecular basis for tissue remodeling and regeneration. Am J Pathol. 2001 Jun; 158(6):1899-901.
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  86. Friedman TM, Statton D, Jones SC, Berger MA, Murphy GF, Korngold R. Vbeta spectratype analysis reveals heterogeneity of CD4+ T-cell responses to minor histocompatibility antigens involved in graft-versus-host disease: correlations with epithelial tissue infiltrate. Biol Blood Marrow Transplant. 2001; 7(1):2-13.
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  87. Kim JC, Murphy GF. Dysplastic melanocytic nevi and prognostically indeterminate nevomelanomatoid proliferations. Clin Lab Med. 2000 Dec; 20(4):691-712.
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  88. Baron JA, Monzon F, Galaria N, Murphy GF. Angiomatoid melanoma: a novel pattern of differentiation in invasive periocular desmoplastic malignant melanoma. Hum Pathol. 2000 Dec; 31(12):1520-2.
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  89. van den Brink MR, Moore E, Horndasch KJ, Crawford JM, Murphy GF, Burakoff SJ. Fas ligand-deficient gld mice are more susceptible to graft-versus-host-disease. Transplantation. 2000 Jul 15; 70(1):184-91.
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  90. Monteiro MR, Murphy EE, Galaria NA, Whitaker-Menezes D, Murphy GF. Cytological alterations in dermal dendrocytes in vitro: evidence for transformation to a non-dendritic phenotype. Br J Dermatol. 2000 Jul; 143(1):84-90.
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  91. Humphreys TR, Monteiro MR, Murphy GF. Mast cells and dendritic cells in basal cell carcinoma stroma. Dermatol Surg. 2000 Mar; 26(3):200-3; discussion 203-4.
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  92. Alvarez F, Atkison PR, Grant DR, Guilbault N, Jones AB, Kim PS, Kneteman NM, Laurin L, Martin SR, Murphy GF, Paradis K, Shapiro J, Smith LJ, Superina RA. NOF-11: a one-year pediatric randomized double-blind comparison of neoral versus sandimmune in orthotopic liver transplantation. Transplantation. 2000 Jan 15; 69(1):87-92.
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  93. van Den Brink MR, Moore E, Horndasch KJ, Crawford JM, Hoffman J, Murphy GF, Burakoff SJ. Fas-deficient lpr mice are more susceptible to graft-versus-host disease. J Immunol. 2000 Jan 1; 164(1):469-80.
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  94. Gould HJ, Mackay GA, Karagiannis SN, O'Toole CM, Marsh PJ, Daniel BE, Coney LR, Zurawski VR, Joseph M, Capron M, Gilbert M, Murphy GF, Korngold R. Comparison of IgE and IgG antibody-dependent cytotoxicity in vitro and in a SCID mouse xenograft model of ovarian carcinoma. Eur J Immunol. 1999 Nov; 29(11):3527-37.
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  95. Heinonen S, Männikkö M, Klement JF, Whitaker-Menezes D, Murphy GF, Uitto J. Targeted inactivation of the type VII collagen gene (Col7a1) in mice results in severe blistering phenotype: a model for recessive dystrophic epidermolysis bullosa. J Cell Sci. 1999 Nov; 112 ( Pt 21):3641-8.
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  96. Monteiro MR, Shapiro SS, Takafuta T, Menezes DW, Murphy GF. Von Willebrand factor receptor GPIb alpha is expressed by human factor XIIIa-positive dermal dendrocytes and is upregulated by mast cell degranulation. J Invest Dermatol. 1999 Aug; 113(2):272-6.
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  97. Elder DE, Murphy GF, Lavker RL. Wallace H. Clark, Jr., MD: a biography and annotated bibliography. Hum Pathol. 1999 May; 30(5):491-7.
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  98. Murphy GF, Mihm MC. Recognition and evaluation of cytological dysplasia in acquired melanocytic nevi. Hum Pathol. 1999 May; 30(5):506-12.
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  99. Wille JJ, Kydonieus AF, Murphy GF. cis-urocanic acid induces mast cell degranulation and release of preformed TNF-alpha: A possible mechanism linking UVB and cis-urocanic acid to immunosuppression of contact hypersensitivity. Skin Pharmacol Appl Skin Physiol. 1999 Jan-Apr; 12(1-2):18-27.
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  100. Yoo YH, Park BS, Whitaker-Menezes D, Korngold R, Murphy GF. Dermal dendrocytes participate in the cellular pathology of experimental acute graft-versus-host disease. J Cutan Pathol. 1998 Sep; 25(8):426-34.
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  101. Takafuta T, Wu G, Murphy GF, Shapiro SS. Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha. J Biol Chem. 1998 Jul 10; 273(28):17531-8.
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  102. Egan CL, Viglione-Schneck MJ, Walsh LJ, Green B, Trojanowski JQ, Whitaker-Menezes D, Murphy GF. Characterization of unmyelinated axons uniting epidermal and dermal immune cells in primate and murine skin. J Cutan Pathol. 1998 Jan; 25(1):20-9.
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  103. Mihm MC, Murphy GF. Malignant melanoma in situ: an oxymoron whose time has come. Hum Pathol. 1998 Jan; 29(1):6-7.
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  104. Murphy GF, Katz S, Kligman AM. Topical tretinoin replenishes CD1a-positive epidermal Langerhans cells in chronically photodamaged human skin. J Cutan Pathol. 1998 Jan; 25(1):30-4.
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  105. Roosje PJ, Whitaker-Menezes D, Goldschmidt MH, Moore PF, Willemse T, Murphy GF. Feline atopic dermatitis. A model for Langerhans cell participation in disease pathogenesis. Am J Pathol. 1997 Oct; 151(4):927-32.
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  106. Korngold R, Jameson BA, McDonnell JM, Leighton C, Sutton BJ, Gould HJ, Murphy GF. Peptide analogs that inhibit IgE-Fc epsilon RI alpha interactions ameliorate the development of lethal graft-versus-host disease. Biol Blood Marrow Transplant. 1997 Oct; 3(4):187-93.
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  107. Christofidou-Solomidou M, Bridges M, Murphy GF, Albelda SM, DeLisser HM. Expression and function of endothelial cell alpha v integrin receptors in wound-induced human angiogenesis in human skin/SCID mice chimeras. Am J Pathol. 1997 Oct; 151(4):975-83.
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  108. Christofidou-Solomidou M, Longley BJ, Whitaker-Menezes D, Albelda SM, Murphy GF. Human skin/SCID mouse chimeras as an in vivo model for human cutaneous mast cell hyperplasia. J Invest Dermatol. 1997 Jul; 109(1):102-7.
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  109. Koch PJ, Mahoney MG, Ishikawa H, Pulkkinen L, Uitto J, Shultz L, Murphy GF, Whitaker-Menezes D, Stanley JR. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol. 1997 Jun 2; 137(5):1091-102.
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  110. Yoo YH, Gilliam AC, Whitaker-Menezes D, Korngold R, Murphy GF. Experimental induction and ultrastructural characterization of apoptosis in murine acute cutaneous graft-versus-host disease. Arch Dermatol Res. 1997 Jun; 289(7):389-98.
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  111. Longley BJ, Tyrrell L, Lu S, Ma Y, Klump V, Murphy GF. Chronically KIT-stimulated clonally-derived human mast cells show heterogeneity in different tissue microenvironments. J Invest Dermatol. 1997 May; 108(5):792-6.
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  112. Christofidou-Solomidou M, Albelda SM, Bennett FC, Murphy GF. Experimental production and modulation of human cytotoxic dermatitis in human-murine chimeras. Am J Pathol. 1997 Feb; 150(2):631-9.
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  113. Townsend RM, Briggs C, Marini JC, Murphy GF, Korngold R. Inhibitory effect of a CD4-CDR3 peptide analog on graft-versus-host disease across a major histocompatibility complex-haploidentical barrier. Blood. 1996 Oct 15; 88(8):3038-47.
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  114. Murphy GF. A story of mice and men: SCID mouse-human skin chimeras in immunology research. J Invest Dermatol. 1996 Oct; 107(4):529-30.
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  115. Gilliam AC, Whitaker-Menezes D, Korngold R, Murphy GF. Apoptosis is the predominant form of epithelial target cell injury in acute experimental graft-versus-host disease. J Invest Dermatol. 1996 Sep; 107(3):377-83.
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  116. Griffin TD, Murphy GF, Sueki H, Telegan B, Johnson WC, Ditre CM, Yu RJ, Van Scott EJ. Increased factor XIIIa transglutaminase expression in dermal dendrocytes after treatment with alpha-hydroxy acids: potential physiologic significance. J Am Acad Dermatol. 1996 Feb; 34(2 Pt 1):196-203.
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  117. Christofidou-Solomidou M, Murphy GF, Albelda SM. Induction of E-selectin-dependent leukocyte recruitment by mast cell degranulation in human skin grafts transplanted on SCID mice. Am J Pathol. 1996 Jan; 148(1):177-88.
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  118. Pilewski JM, Yan HC, Juhasz I, Christofidou-Solomidou M, Williams J, Murphy GF, Albelda SM. Modulation of adhesion molecules by cytokines in vivo using human/severe combined immunodeficient (SCID) mouse chimeras. J Clin Immunol. 1995 Nov; 15(6 Suppl):122S-129S.
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  119. Sueki H, Telegan B, Murphy GF. Computer-assisted three-dimensional reconstruction of human dermal dendrocytes. J Invest Dermatol. 1995 Nov; 105(5):704-8.
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  120. Asahina A, Hosoi J, Murphy GF, Granstein RD. Calcitonin gene-related peptide modulates Langerhans cell antigen-presenting function. Proc Assoc Am Physicians. 1995 Jul; 107(2):242-4.
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  121. Kaminer MS, Murphy GF, Zweiman B, Lavker RM. Connective tissue mast cells exhibit time-dependent degranulation heterogeneity. Clin Diagn Lab Immunol. 1995 May; 2(3):297-301.
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  122. Jetté L, Pouliot JF, Murphy GF, Béliveau R. Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated protein. Biochem J. 1995 Feb 1; 305 ( Pt 3):761-6.
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  123. Weiss RR, Whitaker-Menezes D, Longley J, Bender J, Murphy GF. Human dermal endothelial cells express membrane-associated mast cell growth factor. J Invest Dermatol. 1995 Jan; 104(1):101-6.
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  124. Whitaker-Menezes D, Schechter NM, Murphy GF. Serine proteinases are regionally segregated within mast cell granules. Lab Invest. 1995 Jan; 72(1):34-41.
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  125. Murphy GF, Sueki H, Teuscher C, Whitaker D, Korngold R. Role of mast cells in early epithelial target cell injury in experimental acute graft-versus-host disease. J Invest Dermatol. 1994 Apr; 102(4):451-61.
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  126. Juhasz I, Lazarus GS, Murphy GF, Shih IM, Herlyn M. Development of pemphigus vulgaris-like lesions in severe combined immunodeficiency disease mice reconstituted with lymphocytes from patients. J Clin Invest. 1993 Nov; 92(5):2401-7.
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  127. Juhasz I, Murphy GF, Yan HC, Herlyn M, Albelda SM. Regulation of extracellular matrix proteins and integrin cell substratum adhesion receptors on epithelium during cutaneous human wound healing in vivo. Am J Pathol. 1993 Nov; 143(5):1458-69.
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  128. Berger R, Albelda SM, Berd D, Ioffreda M, Whitaker D, Murphy GF. Expression of platelet-endothelial cell adhesion molecule-1 (PECAM-1) during melanoma-induced angiogenesis in vivo. J Cutan Pathol. 1993 Oct; 20(5):399-406.
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  129. de Chadarévian JP, Raphael SA, Murphy GF. Histologic, ultrastructural, and immunocytochemical features of the granulomas seen in a child with the syndrome of familial granulomatous arthritis, uveitis, and rash. Arch Pathol Lab Med. 1993 Oct; 117(10):1050-2.
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  130. Ioffreda MD, Whitaker D, Murphy GF. Mast cell degranulation upregulates alpha 6 integrins on epidermal Langerhans cells. J Invest Dermatol. 1993 Aug; 101(2):150-4.
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  131. Sueki H, Whitaker D, Buchsbaum M, Murphy GF. Novel interactions between dermal dendrocytes and mast cells in human skin. Implications for hemostasis and matrix repair. Lab Invest. 1993 Aug; 69(2):160-72.
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  132. Juhasz I, Albelda SM, Elder DE, Murphy GF, Adachi K, Herlyn D, Valyi-Nagy IT, Herlyn M. Growth and invasion of human melanomas in human skin grafted to immunodeficient mice. Am J Pathol. 1993 Aug; 143(2):528-37.
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  133. Wayner EA, Gil SG, Murphy GF, Wilke MS, Carter WG. Epiligrin, a component of epithelial basement membranes, is an adhesive ligand for alpha 3 beta 1 positive T lymphocytes. J Cell Biol. 1993 Jun; 121(5):1141-52.
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  134. Hosoi J, Murphy GF, Egan CL, Lerner EA, Grabbe S, Asahina A, Granstein RD. Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide. Nature. 1993 May 13; 363(6425):159-63.
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  135. Yan HC, Juhasz I, Pilewski J, Murphy GF, Herlyn M, Albelda SM. Human/severe combined immunodeficient mouse chimeras. An experimental in vivo model system to study the regulation of human endothelial cell-leukocyte adhesion molecules. J Clin Invest. 1993 Mar; 91(3):986-96.
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  136. Murphy GF, Radu A, Kaminer M, Berd D. Autologous melanoma vaccine induces inflammatory responses in melanoma metastases: relevance to immunologic regression and immunotherapy. J Invest Dermatol. 1993 Mar; 100(3):335S-341S.
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  137. Buchsbaum ME, Kupper TS, Murphy GF. Differential induction of intercellular adhesion molecule-1 in human skin by recombinant cytokines. J Cutan Pathol. 1993 Feb; 20(1):21-7.
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  138. Jaworsky C, Kligman AM, Murphy GF. Characterization of inflammatory infiltrates in male pattern alopecia: implications for pathogenesis. Br J Dermatol. 1992 Sep; 127(3):239-46.
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  139. Walsh LJ, Murphy GF. Role of adhesion molecules in cutaneous inflammation and neoplasia. J Cutan Pathol. 1992 Jun; 19(3):161-71.
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  140. Sueki H, Miller SJ, Dzubow LM, Murphy GF. Eccrine syringofibroadenoma (Mascaro): an ultrastructural study. J Cutan Pathol. 1992 Jun; 19(3):232-9.
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  141. Walsh LJ, Goerdt S, Pober JS, Sueki H, Murphy GF. MS-1 sinusoidal endothelial antigen is expressed by factor XIIIa+, HLA-DR+ dermal perivascular dendritic cells. Lab Invest. 1991 Dec; 65(6):732-41.
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  142. Sharpe RJ, Murphy GF, Whitaker D, Galli SJ, Maione TE. Induction of local inflammation by recombinant human platelet factor 4 in the mouse. Cell Immunol. 1991 Oct 1; 137(1):72-80.
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  143. Murphy GF, Lavker RM, Whitaker D, Korngold R. Cytotoxic folliculitis in GvHD. Evidence of follicular stem cell injury and recovery. J Cutan Pathol. 1991 Oct; 18(5):309-14.
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  144. Walsh LJ, Kaminer MS, Lazarus GS, Lavker RM, Murphy GF. Role of laminin in localization of human dermal mast cells. Lab Invest. 1991 Oct; 65(4):433-40.
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  145. Goerdt S, Walsh LJ, Murphy GF, Pober JS. Identification of a novel high molecular weight protein preferentially expressed by sinusoidal endothelial cells in normal human tissues. J Cell Biol. 1991 Jun; 113(6):1425-37.
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  146. Kaminer MS, Lavker RM, Walsh LJ, Whitaker D, Zweiman B, Murphy GF. Extracellular localization of human connective tissue mast cell granule contents. J Invest Dermatol. 1991 Jun; 96(6):857-63.
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  147. Walsh LJ, Trinchieri G, Waldorf HA, Whitaker D, Murphy GF. Human dermal mast cells contain and release tumor necrosis factor alpha, which induces endothelial leukocyte adhesion molecule 1. Proc Natl Acad Sci U S A. 1991 May 15; 88(10):4220-4.
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  148. Murphy GF, Whitaker D, Sprent J, Korngold R. Characterization of target injury of murine acute graft-versus-host disease directed to multiple minor histocompatibility antigens elicited by either CD4+ or CD8+ effector cells. Am J Pathol. 1991 Apr; 138(4):983-90.
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  149. Lavker RM, Dong G, Zheng PS, Murphy GF. Hairless micropig skin. A novel model for studies of cutaneous biology. Am J Pathol. 1991 Mar; 138(3):687-97.
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  150. Waldorf HA, Walsh LJ, Schechter NM, Murphy GF. Early cellular events in evolving cutaneous delayed hypersensitivity in humans. Am J Pathol. 1991 Feb; 138(2):477-86.
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  151. Walsh LJ, Lavker RM, Murphy GF. Determinants of immune cell trafficking in the skin. Lab Invest. 1990 Nov; 63(5):592-600.
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  152. Mirowski G, Austen KF, Chiang L, Horan RF, Sheffer AL, Weidner N, Murphy GF. Characterization of cellular dermal infiltrates in human cutaneous mastocytosis. Lab Invest. 1990 Jul; 63(1):52-62.
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  153. Pensler JM, Murphy GF, Mulliken JB. Clinical and ultrastructural studies of Romberg's hemifacial atrophy. Plast Reconstr Surg. 1990 May; 85(5):669-74; discussion 675-6.
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  154. Matis WL, Lavker RM, Murphy GF. Substance P induces the expression of an endothelial-leukocyte adhesion molecule by microvascular endothelium. J Invest Dermatol. 1990 Apr; 94(4):492-5.
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  155. Murphy GF, Orgill DP, Yannas IV. Partial dermal regeneration is induced by biodegradable collagen-glycosaminoglycan grafts. Lab Invest. 1990 Mar; 62(3):305-13.
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  156. Valyi-Nagy IT, Murphy GF, Mancianti ML, Whitaker D, Herlyn M. Phenotypes and interactions of human melanocytes and keratinocytes in an epidermal reconstruction model. Lab Invest. 1990 Mar; 62(3):314-24.
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  157. Klein LM, Lavker RM, Matis WL, Murphy GF. Degranulation of human mast cells induces an endothelial antigen central to leukocyte adhesion. Proc Natl Acad Sci U S A. 1989 Nov; 86(22):8972-6.
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  158. Lewis RE, Buchsbaum M, Whitaker D, Murphy GF. Intercellular adhesion molecule expression in the evolving human cutaneous delayed hypersensitivity reaction. J Invest Dermatol. 1989 Nov; 93(5):672-7.
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  159. Yannas IV, Lee E, Orgill DP, Skrabut EM, Murphy GF. Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin. Proc Natl Acad Sci U S A. 1989 Feb; 86(3):933-7.
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  160. Ferrara JL, Guillen FJ, van Dijken PJ, Marion A, Murphy GF, Burakoff SJ. Evidence that large granular lymphocytes of donor origin mediate acute graft-versus-host disease. Transplantation. 1989 Jan; 47(1):50-4.
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  161. Shea CR, Whitaker D, Murphy GF, Hasan T. Ultrastructure and dynamics of selective mitochondrial injury in carcinoma cells after doxycycline photosensitization in vitro. Am J Pathol. 1988 Nov; 133(2):381-8.
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  162. Ringler DJ, Murphy GF. Transmucosal passage of lentiviruses and the epinodal hypothesis: relevance to the pathogenesis of AIDS. Mod Pathol. 1988 Mar; 1(2):135-9.
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  163. Tong AK, Murphy GF, Mihm MC. Dysplastic nevus: a formal histogenetic precursor of malignant melanoma. Monogr Pathol. 1988; (30):10-8.
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  164. Messadi DV, Pober JS, Murphy GF. Effects of recombinant gamma-interferon on HLA-DR and DQ expression by skin cells in short-term organ culture. Lab Invest. 1988 Jan; 58(1):61-7.
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  165. Murphy GF, Mihm MC. Histologic reporting of malignant melanoma. Monogr Pathol. 1988; (30):79-93.
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  166. Murphy GF, Austen KF, Fonferko E, Sheffer AL. Morphologically distinctive forms of cutaneous mast cell degranulation induced by cold and mechanical stimuli: an ultrastructural study. J Allergy Clin Immunol. 1987 Oct; 80(4):603-11.
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  167. Polla LL, Margolis RJ, Dover JS, Whitaker D, Murphy GF, Jacques SL, Anderson RR. Melanosomes are a primary target of Q-switched ruby laser irradiation in guinea pig skin. J Invest Dermatol. 1987 Sep; 89(3):281-6.
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  168. Messadi DV, Pober JS, Fiers W, Gimbrone MA, Murphy GF. Induction of an activation antigen on postcapillary venular endothelium in human skin organ culture. J Immunol. 1987 Sep 1; 139(5):1557-62.
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  169. Granstein RD, Askari M, Whitaker D, Murphy GF. Epidermal cells in activation of suppressor lymphocytes: further characterization. J Immunol. 1987 Jun 15; 138(12):4055-62.
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  170. Tong AK, Tan OT, Boll J, Parrish JA, Murphy GF. Ultrastructure: effects of melanin pigment on target specificity using a pulsed dye laser (577 nm). J Invest Dermatol. 1987 Jun; 88(6):747-52.
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  171. Weinberg DS, Pinkus GS, Murphy GF. Tonsillar epithelial dendritic cells. Demonstration by lectin binding, immunohistochemical characterization, and ultrastructure. Lab Invest. 1987 Jun; 56(6):622-8.
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  172. Granstein RD, Murphy GF, Margolis RJ, Byrne MH, Amento EP. Gamma-interferon inhibits collagen synthesis in vivo in the mouse. J Clin Invest. 1987 Apr; 79(4):1254-8.
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  173. Ringler DJ, Hancock WW, King NW, Murphy GF. Characterization of nonhuman primate epidermal and dermal dendritic cells with monoclonal antibodies. A study of Langerhans cells and indeterminate cells in the rhesus monkey. Lab Invest. 1987 Mar; 56(3):313-20.
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  174. Ringler DJ, Hancock WW, King NW, Letvin NL, Daniel MD, Desrosiers RC, Murphy GF. Immunophenotypic characterization of the cutaneous exanthem of SIV-infected rhesus monkeys. Apposition of degenerative Langerhans cells and cytotoxic lymphocytes during the development of acquired immunodeficiency syndrome. Am J Pathol. 1987 Feb; 126(2):199-207.
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  175. Ringler DJ, Murphy GF, King NW. An erythematous maculopapular eruption in macaques infected with an HTLV-III-like virus (STLV-III). J Invest Dermatol. 1986 Nov; 87(5):674-7.
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  176. Ferrara JL, Marion A, McIntyre JF, Murphy GF, Burakoff SJ. Amelioration of acute graft vs host disease due to minor histocompatibility antigens by in vivo administration of anti-interleukin 2 receptor antibody. J Immunol. 1986 Sep 15; 137(6):1874-7.
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  177. Guillén FJ, Ferrara J, Hancock WW, Messadi D, Fonferko E, Burakoff SJ, Murphy GF. Acute cutaneous graft-versus-host disease to minor histocompatibility antigens in a murine model. Evidence that large granular lymphocytes are effector cells in the immune response. Lab Invest. 1986 Jul; 55(1):35-42.
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  178. Guillén FJ, Hancock WW, Towpik E, Kupiec-Weglinski JW, Rickles FR, Tilney NL, Murphy GF. Inhibition of rat skin allograft rejection by cyclosporine. In situ characterization of the impaired local immune response. Transplantation. 1986 Jun; 41(6):734-9.
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  179. Murphy GF, Messadi D, Fonferko E, Hancock WW. Phenotypic transformation of macrophages to Langerhans cells in the skin. Am J Pathol. 1986 Jun; 123(3):401-6.
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  180. Merot Y, Gravallese E, Guillén FJ, Murphy GF. Lymphocyte subsets and Langerhans' cells in toxic epidermal necrolysis. Report of a case. Arch Dermatol. 1986 Apr; 122(4):455-8.
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  181. Ferrara J, Guillen FJ, Sleckman B, Burakoff SJ, Murphy GF. Cutaneous acute graft-versus-host disease to minor histocompatibility antigens in a murine model: histologic analysis and correlation to clinical disease. J Invest Dermatol. 1986 Apr; 86(4):371-5.
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  182. Murphy GF, Sanchez NP, Flynn TC, Sanchez JL, Mihm MC, Soter NA. Erythema nodosum leprosum: nature and extent of the cutaneous microvascular alterations. J Am Acad Dermatol. 1986 Jan; 14(1):59-69.
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  183. Murphy GF, Guillén FJ, Flynn TC. Cytotoxic T lymphocytes and phenotypically abnormal epidermal dendritic cells in fixed cutaneous eruptions. Hum Pathol. 1985 Dec; 16(12):1264-71.
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  184. Guillén FJ, Day CL, Murphy GF. Expression of activation antigens by T cells infiltrating basal cell carcinomas. J Invest Dermatol. 1985 Sep; 85(3):203-6.
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  185. Schwartz LB, Foley JV, Austen KF, Soter NA, Shepard R, Murphy GF. Localization of tryptase to human cutaneous mast cells and keratinocytes by immunofluorescence and immunoperoxidase cytochemistry with monoclonal antitryptase antibody. J Allergy Clin Immunol. 1985 Aug; 76(2 Pt 1):182-8.
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  186. Murphy GF, Lopansri S, Mihm MC. Capsule dermatopathology: clinicopathologic types of malignant melanoma--relevance to biologic behavior and diagnostic surgical approach. J Dermatol Surg Oncol. 1985 Jul; 11(7):674-82.
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  187. Merot Y, Mazoujian G, Pinkus G, Momtaz-T K, Murphy GF. Extramammary Paget's disease of the perianal and perineal regions. Evidence of apocrine derivation. Arch Dermatol. 1985 Jun; 121(6):750-2.
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  188. Sheffer AL, Tong AK, Murphy GF, Lewis RA, McFadden ER, Austen KF. Exercise-induced anaphylaxis: a serious form of physical allergy associated with mast cell degranulation. J Allergy Clin Immunol. 1985 Apr; 75(4):479-84.
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  189. Guillen FJ, Murphy GF. Capsule dermatopathology: nevomelanocytic lesions with spindle cell differentiation. J Dermatol Surg Oncol. 1985 Mar; 11(3):225-30.
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  190. Murphy GF, Merot Y, Tong AK, Smith B, Mihm MC. Depletion and repopulation of epidermal dendritic cells after allogeneic bone marrow transplantation in humans. J Invest Dermatol. 1985 Mar; 84(3):210-4.
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  191. Murphy GF, Bronstein BR, Knowles RW, Bhan AK. Ultrastructural documentation of M241 glycoprotein on dendritic and endothelial cells in normal human skin. Lab Invest. 1985 Mar; 52(3):264-9.
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  192. Murphy GF. Cell membrane glycoproteins and Langerhans cells. Hum Pathol. 1985 Feb; 16(2):103-12.
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  193. Murphy GF. Cytokeratin typing of cutaneous tumors: a new immunochemical probe for cellular differentiation and malignant transformation. J Invest Dermatol. 1985 Jan; 84(1):1-2.
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  194. Murphy GF, Fonferko E, Flotte T, Bhan AK. Association of basal-lamina defects with epidermal and dermal T6-positive cells: evidence of Langerhans-cell migration. Arch Dermatol Res. 1985; 278(2):126-32.
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  195. Flynn TC, Harrist TJ, Murphy GF, Loss RW, Moschella SL. Neutrophilic eccrine hidradenitis: a distinctive rash associated with cytarabine therapy and acute leukemia. J Am Acad Dermatol. 1984 Oct; 11(4 Pt 1):584-90.
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  196. Flotte TJ, Murphy GF, Bhan AK. Demonstration of T200 on human Langerhans cell surface membranes. J Invest Dermatol. 1984 May; 82(5):535-7.
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  197. Murphy GF, Flynn TC, Rice RH, Pinkus GS. Involucrin expression in normal and neoplastic human skin: a marker for keratinocyte differentiation. J Invest Dermatol. 1984 May; 82(5):453-7.
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  198. Smith SB, Harrist TJ, Murphy GF, Halperin AJ, Newell JB, Fallon JT, Fine JD, Mihm MC. Linear IgA bullous dermatosis v dermatitis herpetiformis. Quantitative measurements of dermoepidermal alterations. Arch Dermatol. 1984 Mar; 120(3):324-8.
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  199. Murphy GF, Shepard RS, Paul BS, Menkes A, Anderson RR, Parrish JA. Organelle-specific injury to melanin-containing cells in human skin by pulsed laser irradiation. Lab Invest. 1983 Dec; 49(6):680-5.
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  200. Murphy GF, Shepard RS, Harrist TJ, Bronstein BR, Bhan AK. Ultrastructural documentation of HLA-DR antigen reactivity in normal human acrosyringial epithelium. J Invest Dermatol. 1983 Aug; 81(2):181-3.
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  201. Murphy GF. Techniques for the immunoelectron microscopy of Langerhans cells. J Invest Dermatol. 1983 Jul; 81(1):83.
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  202. Parrish JA, Anderson RR, Harrist T, Paul B, Murphy GF. Selective thermal effects with pulsed irradiation from lasers: from organ to organelle. J Invest Dermatol. 1983 Jun; 80(1 Suppl):75s-80s.
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  203. Bronstein BR, Murphy GF, Harrist TJ, Ruiter DJ, Mihm MC, Bhan AK. Location of HLA-A,B,C antigens in dendritic cells of normal human skin: an immunoelectron microscopic study. J Invest Dermatol. 1983 Jun; 80(6):481-4.
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  204. Parrish JA, Anderson RR, Harrist T, Paul B, Murphy GF. Selective thermal effects with pulsed irradiation from lasers: from organ to organelle. J Invest Dermatol. 1983 Jun; 80 Suppl:75s-80s.
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  205. Murphy GF, Bhan AK, Harrist TJ, Mihm MC. In situ identification of T6-positive cells in normal human dermis by immunoelectron microscopy. Br J Dermatol. 1983 Apr; 108(4):423-31.
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  206. Murphy GF, Krusinski PA, Myzak LA, Ershler WB. Local immune response in basal cell carcinoma: characterization by transmission electron microscopy and monoclonal anti-T6 antibody. J Am Acad Dermatol. 1983 Apr; 8(4):477-85.
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  207. Harrist TJ, Bhan AK, Murphy GF, Sato S, Berman RS, Gellis SE, Freedman S, Mihm MC. Histiocytosis-X: in situ characterization of cutaneous infiltrates with monoclonal antibodies. Am J Clin Pathol. 1983 Mar; 79(3):294-300.
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  208. Quay SC, Murphy GF, Mihm MC. Biochemical studies of immune complexes. II. Purification of immune complexes from sera of patients with malignant melanoma. Clin Immunol Immunopathol. 1983 Mar; 26(3):318-26.
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  209. Harrist TJ, Muhlbauer JE, Murphy GF, Mihm MC, Bhan AK. T6 is superior to Ia (HLA-DR) as a marker for Langerhans cells and indeterminate cells in normal epidermis: a monoclonal antibody study. J Invest Dermatol. 1983 Feb; 80(2):100-3.
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  210. Murphy GF, Harrist TJ, Bhan AK, Mihm MC. Distribution of cell surface antigens in histiocytosis X cells. Quantitative immunoelectron microscopy using monoclonal antibodies. Lab Invest. 1983 Jan; 48(1):90-7.
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  211. Soter NA, Murphy GF, Mihm MC. Lymphocytes and necrosis of the cutaneous microvasculature in malignant atrophic papulosis: a refined light microscope study. J Am Acad Dermatol. 1982 Nov; 7(5):620-30.
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  212. Gilchrest BA, Murphy GF, Soter NA. Effect of chronologic aging and ultraviolet irradiation on Langerhans cells in human epidermis. J Invest Dermatol. 1982 Aug; 79(2):85-8.
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  213. Sato S, Murphy GF, Harrist TJ. The genesis of paired cisternae during the mitotic cycle. Am J Pathol. 1982 May; 107(2):150-60.
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  214. Murphy GF, Harrist TJ. Langerhans' cells and identification with antibodies. Arch Pathol Lab Med. 1982 May; 106(5):255-6.
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  215. Harrist TJ, Fine JD, Berman RS, Murphy GF, Mihm MC. Neutrophilic eccrine hidradenitis. A distinctive type of neutrophilic dermatosis associated with myelogenous leukemia and chemotherapy. Arch Dermatol. 1982 Apr; 118(4):263-6.
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  216. Murphy GF, Harrist TJ, Sato S, Mihm MC. Microvascular injury in lymphomatoid granulomatosis involving the skin. An ultrastructural study. Arch Dermatol. 1981 Dec; 117(12):804-8.
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  217. Bhan AK, Harrist TJ, Murphy GF, Mihm MC. T cell subsets and Langerhans cells in lichen planus: in situ characterization using monoclonal antibodies. Br J Dermatol. 1981 Dec; 105(6):617-22.
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  218. Murphy GF, Bhan AK, Sato S, Harrist TJ, Mihm MC. Characterization of Langerhans cells by the use of monoclonal antibodies. Lab Invest. 1981 Nov; 45(5):465-8.
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  219. Adrian RM, Murphy GF, Sato S, Granstein RD, Fitzpatrick TB, Sober AJ. Diffuse melanosis secondary to metastatic malignant melanoma. Light and electron microscopic findings. J Am Acad Dermatol. 1981 Sep; 5(3):308-18.
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  220. Sato S, Murphy GF, Bernhard JD, Mihm MC, Fitzpatrick TB. Ultrastructural and x-ray microanalytical observations of minocycline-related hyperpigmentation of the skin. J Invest Dermatol. 1981 Sep; 77(3):264-71.
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  221. Murphy GF, Bhan AK, Sato S, Mihm MC, Harrist TJ. A new immunologic marker for human Langerhans cells. N Engl J Med. 1981 Mar 26; 304(13):791-2.
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  222. Kopans DB, Meyer JE, Murphy GF. Benign lymph nodes associated with dermatitis presenting as breast masses. Radiology. 1980 Oct; 137(1 Pt 1):15-9.
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  223. Harrist TJ, Murphy GF, Mihm MC. Oral warty dyskeratoma. Arch Dermatol. 1980 Aug; 116(8):929-31.
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