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Patrick Lee Purdon, PH.D.

TitleAssistant Professor of Anaesthesia
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMassachusetts General Hospital
Room 4005
149 13th Street
Charlestown MA 02129
Phone617/726-1060
Fax617/726-8410

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mukamel EA, Pirondini E, Babadi B, Wong KF, Pierce ET, Harrell PG, Walsh JL, Salazar-Gomez AF, Cash SS, Eskandar EN, Weiner VS, Brown EN, Purdon PL. A Transition in Brain State during Propofol-Induced Unconsciousness. J Neurosci. 2014 Jan 15; 34(3):839-45.
    View in: PubMed
  2. Ching S, Liberman MY, Chemali JJ, Westover MB, Kenny JD, Solt K, Purdon PL, Brown EN. Real-time Closed-loop Control in a Rodent Model of Medically Induced Coma Using Burst Suppression. Anesthesiology. 2013 Oct; 119(4):848-60.
    View in: PubMed
  3. Babadi B, Obregon-Henao G, Lamus C, Hämäläinen MS, Brown EN, Purdon PL. A Subspace Pursuit-based Iterative Greedy Hierarchical solution to the neuromagnetic inverse problem. Neuroimage. 2014 Feb 15; 87:427-43.
    View in: PubMed
  4. Chemali J, Ching S, Purdon PL, Solt K, Brown EN. Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression. J Neural Eng. 2013 Oct; 10(5):056017.
    View in: PubMed
  5. Brown EN, Purdon PL. The aging brain and anesthesia. Curr Opin Anaesthesiol. 2013 Aug; 26(4):414-9.
    View in: PubMed
  6. Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL. Local cortical dynamics of burst suppression in the anaesthetized brain. Brain. 2013 Sep; 136(Pt 9):2727-37.
    View in: PubMed
  7. Brandon Westover M, Shafi MM, Ching S, Chemali JJ, Purdon PL, Cash SS, Brown EN. Real-time segmentation of burst suppression patterns in critical care EEG monitoring. J Neurosci Methods. 2013 Sep 30; 219(1):131-41.
    View in: PubMed
  8. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ. Thalamocortical mechanisms for the anteriorization of alpha rhythms during propofol-induced unconsciousness. J Neurosci. 2013 Jul 3; 33(27):11070-5.
    View in: PubMed
  9. Prerau MJ, Purdon PL, Eden UT. Tracking non-stationary spectral peak structure in EEG data. Conf Proc IEEE Eng Med Biol Soc. 2013 Jul; 2013:417-20.
    View in: PubMed
  10. Krishnaswamy P, Bonmassar G, Purdon PL, Brown EN. Reference-free harmonic regression technique to remove EEG-fMRI ballistocardiogram artifacts. Conf Proc IEEE Eng Med Biol Soc. 2013 Jul; 2013:5426-9.
    View in: PubMed
  11. Purdon PL, Pierce ET, Mukamel EA, Prerau MJ, Walsh JL, Wong KF, Salazar-Gomez AF, Harrell PG, Sampson AL, Cimenser A, Ching S, Kopell NJ, Tavares-Stoeckel C, Habeeb K, Merhar R, Brown EN. Electroencephalogram signatures of loss and recovery of consciousness from propofol. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):E1142-51.
    View in: PubMed
  12. Lewis LD, Weiner VS, Mukamel EA, Donoghue JA, Eskandar EN, Madsen JR, Anderson WS, Hochberg LR, Cash SS, Brown EN, Purdon PL. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2012 Dec 4; 109(49):E3377-86.
    View in: PubMed
  13. Citi L, Valenza G, Purdon PL, Brown EN, Barbieri R. Monitoring heartbeat nonlinear dynamics during general anesthesia by using the instantaneous dominant Lyapunov exponent. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012:3124-7.
    View in: PubMed
  14. Obregon-Henao G, Babadi B, Lamus C, Brown EN, Purdon PL. A fast iterative greedy algorithm for MEG source localization. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012:6748-51.
    View in: PubMed
  15. Sampson AL, Babadi B, Prerau MJ, Mukamel EA, Brown EN, Purdon PL. Beamforming approach to phase-amplitude modulation analysis of multi-channel EEG. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012:6731-4.
    View in: PubMed
  16. Pirondini E, Babadi B, Lamus C, Brown EN, Purdon PL. A spatially-regularized dynamic source localization algorithm for EEG. Conf Proc IEEE Eng Med Biol Soc. 2012 Aug; 2012:6752-5.
    View in: PubMed
  17. Ching S, Purdon PL, Vijayan S, Kopell NJ, Brown EN. A neurophysiological-metabolic model for burst suppression. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3095-100.
    View in: PubMed
  18. Chen Z, Purdon PL, Brown EN, Barbieri R. A unified point process probabilistic framework to assess heartbeat dynamics and autonomic cardiovascular control. Front Physiol. 2012; 3:4.
    View in: PubMed
  19. Lamus C, Hämäläinen MS, Temereanca S, Brown EN, Purdon PL. A spatiotemporal dynamic distributed solution to the MEG inverse problem. Neuroimage. 2012 Nov 1; 63(2):894-909.
    View in: PubMed
  20. Cimenser A, Purdon PL, Pierce ET, Walsh JL, Salazar-Gomez AF, Harrell PG, Tavares-Stoeckel C, Habeeb K, Brown EN. Tracking brain states under general anesthesia by using global coherence analysis. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8832-7.
    View in: PubMed
  21. Wong KF, Mukamel EA, Salazar AF, Pierce ET, Harrell PG, Walsh JL, Sampson A, Brown EN, Purdon PL. Robust time-varying multivariate coherence estimation: application to electroencephalogram recordings during general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:4725-8.
    View in: PubMed
  22. Mukamel EA, Wong KF, Prerau MJ, Brown EN, Purdon PL. Phase-based measures of cross-frequency coupling in brain electrical dynamics under general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1981-4.
    View in: PubMed
  23. Wong KF, Smith AC, Pierce ET, Harrell PG, Walsh JL, Salazar AF, Tavares CL, Cimenser A, Prerau MJ, Mukamel EA, Sampson A, Purdon PL, Brown EN. Bayesian analysis of trinomial data in behavioral experiments and its application to human studies of general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:4705-8.
    View in: PubMed
  24. Brown EN, Purdon PL, Van Dort CJ. General anesthesia and altered states of arousal: a systems neuroscience analysis. Annu Rev Neurosci. 2011; 34:601-28.
    View in: PubMed
  25. Chen Z, Citi L, Purdon PL, Brown EN, Barbieri R. Instantaneous assessment of autonomic cardiovascular control during general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:8444-7.
    View in: PubMed
  26. Ching S, Cimenser A, Purdon PL, Brown EN, Kopell NJ. Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22665-70.
    View in: PubMed
  27. Chen Z, Purdon PL, Harrell G, Pierce ET, Walsh J, Brown EN, Barbieri R. Dynamic assessment of baroreflex control of heart rate during induction of propofol anesthesia using a point process method. Ann Biomed Eng. 2011 Jan; 39(1):260-76.
    View in: PubMed
  28. Chen Z, Purdon PL, Brown EN, Barbieri R. A differential autoregressive modeling approach within a point process framework for non-stationary heartbeat intervals analysis. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:3567-70.
    View in: PubMed
  29. Napadow V, Dhond R, Park K, Kim J, Makris N, Kwong KK, Harris RE, Purdon PL, Kettner N, Hui KK. Time-variant fMRI activity in the brainstem and higher structures in response to acupuncture. Neuroimage. 2009 Aug 1; 47(1):289-301.
    View in: PubMed
  30. Purdon PL, Pierce ET, Bonmassar G, Walsh J, Harrell PG, Kwo J, Deschler D, Barlow M, Merhar RC, Lamus C, Mullaly CM, Sullivan M, Maginnis S, Skoniecki D, Higgins HA, Brown EN. Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia. Ann N Y Acad Sci. 2009 Mar; 1157:61-70.
    View in: PubMed
  31. Chen Z, Purdon PL, Pierce ET, Harrell G, Walsh J, Salazar AF, Tavares CL, Brown EN, Barbieri R. Linear and nonlinear quantification of respiratory sinus arrhythmia during propofol general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:5336-9.
    View in: PubMed
  32. Purdon PL, Millan H, Fuller PL, Bonmassar G. An open-source hardware and software system for acquisition and real-time processing of electrophysiology during high field MRI. J Neurosci Methods. 2008 Nov 15; 175(2):165-86.
    View in: PubMed
  33. Vasios CE, Angelone LM, Purdon PL, Ahveninen J, Belliveau JW, Bonmassar G. EEG/(f)MRI measurements at 7 Tesla using a new EEG cap ("InkCap"). Neuroimage. 2006 Dec; 33(4):1082-92.
    View in: PubMed
  34. Zhang WT, Mainero C, Kumar A, Wiggins CJ, Benner T, Purdon PL, Bolar DS, Kwong KK, Sorensen AG. Strategies for improving the detection of fMRI activation in trigeminal pathways with cardiac gating. Neuroimage. 2006 Jul 15; 31(4):1506-12.
    View in: PubMed
  35. Angelone LM, Vasios CE, Wiggins G, Purdon PL, Bonmassar G. On the effect of resistive EEG electrodes and leads during 7 T MRI: simulation and temperature measurement studies. Magn Reson Imaging. 2006 Jul; 24(6):801-12.
    View in: PubMed
  36. Napadow V, Dhond RP, Purdon P, Kettner N, Makris N, Kwong KK, Hui KK. Correlating acupuncture FMRI in the human brainstem with heart rate variability. Conf Proc IEEE Eng Med Biol Soc. 2005; 5:4496-9.
    View in: PubMed
  37. Bonmassar G, Purdon PL, Jääskeläinen IP, Chiappa K, Solo V, Brown EN, Belliveau JW. Motion and ballistocardiogram artifact removal for interleaved recording of EEG and EPs during MRI. Neuroimage. 2002 Aug; 16(4):1127-41.
    View in: PubMed
  38. Purdon PL, Solo V, Weisskoff RM, Brown EN. Locally regularized spatiotemporal modeling and model comparison for functional MRI. Neuroimage. 2001 Oct; 14(4):912-23.
    View in: PubMed
  39. Solo V, Purdon P, Weisskoff R, Brown E. A signal estimation approach to functional MRI. IEEE Trans Med Imaging. 2001 Jan; 20(1):26-35.
    View in: PubMed
  40. Purdon PL, Weisskoff RM. Effect of temporal autocorrelation due to physiological noise and stimulus paradigm on voxel-level false-positive rates in fMRI. Hum Brain Mapp. 1998; 6(4):239-49.
    View in: PubMed
  41. Hausdorff JM, Purdon PL, Peng CK, Ladin Z, Wei JY, Goldberger AL. Fractal dynamics of human gait: stability of long-range correlations in stride interval fluctuations. J Appl Physiol. 1996 May; 80(5):1448-57.
    View in: PubMed
  42. Cowan ME, Purdon PL. A study of the "paraffin test". J Forensic Sci. 1967 Jan; 12(1):19-36.
    View in: PubMed
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