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Last Name
Institution

Arlene Helen Sharpe, M.D., Ph.D.

TitleGeorge Fabyan Professor of Comparative Pathology
InstitutionHarvard Medical School
DepartmentMicrobiology and Immunobiology
AddressHarvard Medical School
Pathology, NRB-837
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-6568
Fax617/432-6570
Other Positions
TitleCo-Director of HITI
InstitutionHarvard Medical School
DepartmentMicrobiology and Immunobiology


 Research 
 research resources
This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Transgenic Core Facility (BWH) - Core services (11), Instruments (5) and Protocols (7)

 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ioannou M, Alissafi T, Lazaridis I, Deraos G, Matsoukas J, Gravanis A, Mastorodemos V, Plaitakis A, Sharpe A, Boumpas D, Verginis P. Correction: crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease. J Immunol. 2014 Feb 1; 192(3):1334.
    View in: PubMed
  2. Horne-Debets JM, Faleiro R, Karunarathne DS, Liu XQ, Lineburg KE, Poh CM, Grotenbreg GM, Hill GR, Macdonald KP, Good MF, Renia L, Ahmed R, Sharpe AH, Wykes MN. PD-1 Dependent Exhaustion of CD8(+) T Cells Drives Chronic Malaria. Cell Rep. 2013 Dec 12; 5(5):1204-13.
    View in: PubMed
  3. Chiang HS, Zhao Y, Song JH, Liu S, Wang N, Terhorst C, Sharpe AH, Basavappa M, Jeffrey KL, Reinecker HC. GEF-H1 controls microtubule-dependent sensing of nucleic acids for antiviral host defenses. Nat Immunol. 2014 Jan; 15(1):63-71.
    View in: PubMed
  4. Saha A, Aoyama K, Taylor PA, Koehn BH, Veenstra RG, Panoskaltsis-Mortari A, Munn DH, Murphy WJ, Azuma M, Yagita H, Fife BT, Sayegh MH, Najafian N, Socie G, Ahmed R, Freeman GJ, Sharpe AH, Blazar BR. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood. 2013 Oct 24; 122(17):3062-73.
    View in: PubMed
  5. Mukherjee G, Geliebter A, Babad J, Santamaria P, Serreze DV, Freeman GJ, Tarbell KV, Sharpe A, Dilorenzo TP. DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8+ T cells independently of PD-1 and PD-L1. Int Immunol. 2013 Nov; 25(11):651-60.
    View in: PubMed
  6. Fuller MJ, Callendret B, Zhu B, Freeman GJ, Hasselschwert DL, Satterfield W, Sharpe AH, Dustin LB, Rice CM, Grakoui A, Ahmed R, Walker CM. Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1). Proc Natl Acad Sci U S A. 2013 Sep 10; 110(37):15001-6.
    View in: PubMed
  7. Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC. SIRT4 Coordinates the Balance between Lipid Synthesis and Catabolism by Repressing Malonyl CoA Decarboxylase. Mol Cell. 2013 Jun 6; 50(5):686-98.
    View in: PubMed
  8. Riella LV, Dada S, Chabtini L, Smith B, Huang L, Dakle P, Mfarrej B, D'Addio F, Adams LT, Kochupurakkal N, Vergani A, Fiorina P, Mellor AL, Sharpe AH, Yagita H, Guleria I. B7h (ICOS-L) Maintains Tolerance at the Fetomaternal Interface. Am J Pathol. 2013 Jun; 182(6):2204-13.
    View in: PubMed
  9. Maazi H, Singh AK, Speak AO, Lombardi V, Lam J, Khoo B, Inn KS, Sharpe AH, Jung JU, Akbari O. Lack of PD-L1 Expression by iNKT Cells Improves the Course of Influenza A Infection. PLoS One. 2013; 8(3):e59599.
    View in: PubMed
  10. Ichinose K, Zhang Z, Koga T, Juang YT, Kis-Tóth K, Sharpe AH, Kuchroo V, Crispín JC, Tsokos GC. Brief Report: Increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice. Arthritis Rheum. 2013 Mar; 65(3):764-9.
    View in: PubMed
  11. Oghumu S, Dong R, Varikuti S, Shawler T, Kampfrath T, Terrazas CA, Lezama-Davila C, Ahmer BM, Whitacre CC, Rajagopalan S, Locksley R, Sharpe AH, Satoskar AR. Distinct Populations of Innate CD8+ T Cells Revealed in a CXCR3 Reporter Mouse. J Immunol. 2013 Mar 1; 190(5):2229-40.
    View in: PubMed
  12. Sage PT, Francisco LM, Carman CV, Sharpe AH. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nat Immunol. 2012 Dec 16; 14(2):152-61.
    View in: PubMed
  13. Chang SY, Song JH, Guleng B, Cotoner CA, Arihiro S, Zhao Y, Chiang HS, O'Keeffe M, Liao G, Karp CL, Kweon MN, Sharpe AH, Bhan A, Terhorst C, Reinecker HC. Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation. Immunity. 2013 Jan 24; 38(1):153-65.
    View in: PubMed
  14. Sham CW, Chan AM, Kwong JM, Caprioli J, Nusinowitz S, Chen B, Lee JG, Gandhi NM, Francisco LM, Sharpe AH, Chen L, Braun J, Gordon LK. Neuronal programmed cell death-1 ligand expression regulates retinal ganglion cell number in neonatal and adult mice. J Neuroophthalmol. 2012 Sep; 32(3):227-37.
    View in: PubMed
  15. Riella LV, Paterson AM, Sharpe AH, Chandraker A. Role of the PD-1 pathway in the immune response. Am J Transplant. 2012 Oct; 12(10):2575-87.
    View in: PubMed
  16. Butte MJ, Lee SJ, Jesneck J, Keir ME, Haining WN, Sharpe AH. CD28 costimulation regulates genome-wide effects on alternative splicing. PLoS One. 2012; 7(6):e40032.
    View in: PubMed
  17. Hirahara K, Ghoreschi K, Yang XP, Takahashi H, Laurence A, Vahedi G, Sciumè G, Hall AO, Dupont CD, Francisco LM, Chen Q, Tanaka M, Kanno Y, Sun HW, Sharpe AH, Hunter CA, O'Shea JJ. Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity. 2012 Jun 29; 36(6):1017-30.
    View in: PubMed
  18. Silberman D, Bucknum A, Bartlett T, Composto G, Kozlowski M, Walker A, Werda A, Cua J, Sharpe AH, Somerville JE, Riggs JE. CD28 ligation increases macrophage suppression of T-cell proliferation. Cell Mol Immunol. 2012 Jul; 9(4):341-9.
    View in: PubMed
  19. Tarrio ML, Grabie N, Bu DX, Sharpe AH, Lichtman AH. PD-1 protects against inflammation and myocyte damage in T cell-mediated myocarditis. J Immunol. 2012 May 15; 188(10):4876-84.
    View in: PubMed
  20. Good-Jacobson KL, Song E, Anderson S, Sharpe AH, Shlomchik MJ. CD80 expression on B cells regulates murine T follicular helper development, germinal center B cell survival, and plasma cell generation. J Immunol. 2012 May 1; 188(9):4217-25.
    View in: PubMed
  21. Sage PT, Varghese LM, Martinelli R, Sciuto TE, Kamei M, Dvorak AM, Springer TA, Sharpe AH, Carman CV. Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. J Immunol. 2012 Apr 15; 188(8):3686-99.
    View in: PubMed
  22. Vijayanand P, Seumois G, Simpson LJ, Abdul-Wajid S, Baumjohann D, Panduro M, Huang X, Interlandi J, Djuretic IM, Brown DR, Sharpe AH, Rao A, Ansel KM. Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity. 2012 Feb 24; 36(2):175-87.
    View in: PubMed
  23. Freeman GJ, Sharpe AH. A new therapeutic strategy for malaria: targeting T cell exhaustion. Nat Immunol. 2012 Feb; 13(2):113-5.
    View in: PubMed
  24. Ioannou M, Alissafi T, Lazaridis I, Deraos G, Matsoukas J, Gravanis A, Mastorodemos V, Plaitakis A, Sharpe A, Boumpas D, Verginis P. Crucial role of granulocytic myeloid-derived suppressor cells in the regulation of central nervous system autoimmune disease. J Immunol. 2012 Feb 1; 188(3):1136-46.
    View in: PubMed
  25. Aubert RD, Kamphorst AO, Sarkar S, Vezys V, Ha SJ, Barber DL, Ye L, Sharpe AH, Freeman GJ, Ahmed R. Antigen-specific CD4 T-cell help rescues exhausted CD8 T cells during chronic viral infection. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21182-7.
    View in: PubMed
  26. Liu SM, Sutherland AP, Zhang Z, Rainbow DB, Quintana FJ, Paterson AM, Sharpe AH, Oukka M, Wicker LS, Kuchroo VK. Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity. J Immunol. 2012 Jan 1; 188(1):155-62.
    View in: PubMed
  27. Shainheit MG, Lasocki KW, Finger E, Larkin BM, Smith PM, Sharpe AH, Dinarello CA, Rutitzky LI, Stadecker MJ. The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL-23 and IL-1ß. J Immunol. 2011 Nov 15; 187(10):5328-35.
    View in: PubMed
  28. Baban B, Chandler PR, Johnson BA, Huang L, Li M, Sharpe ML, Francisco LM, Sharpe AH, Blazar BR, Munn DH, Mellor AL. Physiologic control of IDO competence in splenic dendritic cells. J Immunol. 2011 Sep 1; 187(5):2329-35.
    View in: PubMed
  29. Paterson AM, Brown KE, Keir ME, Vanguri VK, Riella LV, Chandraker A, Sayegh MH, Blazar BR, Freeman GJ, Sharpe AH. The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo. J Immunol. 2011 Aug 1; 187(3):1097-105.
    View in: PubMed
  30. Yang J, Riella LV, Chock S, Liu T, Zhao X, Yuan X, Paterson AM, Watanabe T, Vanguri V, Yagita H, Azuma M, Blazar BR, Freeman GJ, Rodig SJ, Sharpe AH, Chandraker A, Sayegh MH. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J Immunol. 2011 Aug 1; 187(3):1113-9.
    View in: PubMed
  31. Brown DR, Calpe S, Keszei M, Wang N, McArdel S, Terhorst C, Sharpe AH. Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity. J Immunol. 2011 Jul 1; 187(1):21-5.
    View in: PubMed
  32. Koh AE, Njoroge SW, Feliu M, Cook A, Selig MK, Latchman YE, Sharpe AH, Colvin RB, Paul E. The SLAM family member CD48 (Slamf2) protects lupus-prone mice from autoimmune nephritis. J Autoimmun. 2011 Aug; 37(1):48-57.
    View in: PubMed
  33. Jin Y, Chauhan SK, El Annan J, Annan JE, Sage PT, Sharpe AH, Dana R. A novel function for programmed death ligand-1 regulation of angiogenesis. Am J Pathol. 2011 Apr; 178(4):1922-9.
    View in: PubMed
  34. Mfarrej B, Keir M, Dada S, Trikudanathan S, Sayegh MH, Sharpe AH, Guleria I. Anti-CD3 mAb treatment cures PDL1-/-.NOD mice of diabetes but precipitates fatal myocarditis. Clin Immunol. 2011 Jul; 140(1):47-53.
    View in: PubMed
  35. Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N. Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. Am J Transplant. 2011 Apr; 11(4):832-40.
    View in: PubMed
  36. Bu DX, Tarrio M, Maganto-Garcia E, Stavrakis G, Tajima G, Lederer J, Jarolim P, Freeman GJ, Sharpe AH, Lichtman AH. Impairment of the programmed cell death-1 pathway increases atherosclerotic lesion development and inflammation. Arterioscler Thromb Vasc Biol. 2011 May; 31(5):1100-7.
    View in: PubMed
  37. Allen SJ, Hamrah P, Gate D, Mott KR, Mantopoulos D, Zheng L, Town T, Jones C, von Andrian UH, Freeman GJ, Sharpe AH, BenMohamed L, Ahmed R, Wechsler SL, Ghiasi H. The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. J Virol. 2011 May; 85(9):4184-97.
    View in: PubMed
  38. Keszei M, Latchman YE, Vanguri VK, Brown DR, Detre C, Morra M, Arancibia-Carcamo CV, Arancibia CV, Paul E, Calpe S, Castro W, Wang N, Terhorst C, Sharpe AH. Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice. Int Immunol. 2011 Feb; 23(2):149-58.
    View in: PubMed
  39. Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, Levin SD, Sharpe AH, Kuchroo VK. Cutting edge: TIGIT has T cell-intrinsic inhibitory functions. J Immunol. 2011 Feb 1; 186(3):1338-42.
    View in: PubMed
  40. Barber DL, Mayer-Barber KD, Feng CG, Sharpe AH, Sher A. CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition. J Immunol. 2011 Feb 1; 186(3):1598-607.
    View in: PubMed
  41. Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010 Jul; 236:219-42.
    View in: PubMed
  42. Zhou Q, Munger ME, Highfill SL, Tolar J, Weigel BJ, Riddle M, Sharpe AH, Vallera DA, Azuma M, Levine BL, June CH, Murphy WJ, Munn DH, Blazar BR. Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia. Blood. 2010 Oct 7; 116(14):2484-93.
    View in: PubMed
  43. Mueller SN, Vanguri VK, Ha SJ, West EE, Keir ME, Glickman JN, Sharpe AH, Ahmed R. PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest. 2010 Jul; 120(7):2508-15.
    View in: PubMed
  44. Good-Jacobson KL, Szumilas CG, Chen L, Sharpe AH, Tomayko MM, Shlomchik MJ. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nat Immunol. 2010 Jun; 11(6):535-42.
    View in: PubMed
  45. Brown KE, Freeman GJ, Wherry EJ, Sharpe AH. Role of PD-1 in regulating acute infections. Curr Opin Immunol. 2010 Jun; 22(3):397-401.
    View in: PubMed
  46. Paterson AM, Sharpe AH. Taming tissue-specific T cells: CTLA-4 reins in self-reactive T cells. Nat Immunol. 2010 Feb; 11(2):109-11.
    View in: PubMed
  47. El Annan J, Goyal S, Zhang Q, Freeman GJ, Sharpe AH, Dana R. Regulation of T-cell chemotaxis by programmed death-ligand 1 (PD-L1) in dry eye-associated corneal inflammation. Invest Ophthalmol Vis Sci. 2010 Jul; 51(7):3418-23.
    View in: PubMed
  48. Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 2009 Dec 21; 206(13):3015-29.
    View in: PubMed
  49. Ruffner MA, Kim SH, Bianco NR, Francisco LM, Sharpe AH, Robbins PD. B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. Eur J Immunol. 2009 Nov; 39(11):3084-90.
    View in: PubMed
  50. Araki M, Chung D, Liu S, Rainbow DB, Chamberlain G, Garner V, Hunter KM, Vijayakrishnan L, Peterson LB, Oukka M, Sharpe AH, Sobel R, Kuchroo VK, Wicker LS. Genetic evidence that the differential expression of the ligand-independent isoform of CTLA-4 is the molecular basis of the Idd5.1 type 1 diabetes region in nonobese diabetic mice. J Immunol. 2009 Oct 15; 183(8):5146-57.
    View in: PubMed
  51. Akbari O, Stock P, Singh AK, Lombardi V, Lee WL, Freeman GJ, Sharpe AH, Umetsu DT, Dekruyff RH. PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions. Mucosal Immunol. 2010 Jan; 3(1):81-91.
    View in: PubMed
  52. Pot C, Jin H, Awasthi A, Liu SM, Lai CY, Madan R, Sharpe AH, Karp CL, Miaw SC, Ho IC, Kuchroo VK. Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells. J Immunol. 2009 Jul 15; 183(2):797-801.
    View in: PubMed
  53. Paterson AM, Vanguri VK, Sharpe AH. SnapShot: B7/CD28 costimulation. Cell. 2009 May 29; 137(5):974-4.e1.
    View in: PubMed
  54. Chen L, Sham CW, Chan AM, Francisco LM, Wu Y, Mareninov S, Sharpe AH, Freeman GJ, Yang XJ, Braun J, Gordon LK. Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells. Invest Ophthalmol Vis Sci. 2009 Oct; 50(10):4941-8.
    View in: PubMed
  55. Sharpe AH. Mechanisms of costimulation. Immunol Rev. 2009 May; 229(1):5-11.
    View in: PubMed
  56. Reynoso ED, Elpek KG, Francisco L, Bronson R, Bellemare-Pelletier A, Sharpe AH, Freeman GJ, Turley SJ. Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade. J Immunol. 2009 Feb 15; 182(4):2102-12.
    View in: PubMed
  57. Verhagen J, Gabrysová L, Minaee S, Sabatos CA, Anderson G, Sharpe AH, Wraith DC. Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease. Proc Natl Acad Sci U S A. 2009 Mar 3; 106(9):3306-11.
    View in: PubMed
  58. Chen L, Pai V, Levinson R, Sharpe AH, Freeman GJ, Braun J, Gordon LK. Constitutive neuronal expression of the immune regulator, programmed death 1 (PD-1), identified during experimental autoimmune uveitis. Ocul Immunol Inflamm. 2009 Jan-Feb; 17(1):47-55.
    View in: PubMed
  59. Schmidt EM, Wang CJ, Ryan GA, Clough LE, Qureshi OS, Goodall M, Abbas AK, Sharpe AH, Sansom DM, Walker LS. Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity. J Immunol. 2009 Jan 1; 182(1):274-82.
    View in: PubMed
  60. Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho IC, Sharpe AH, Kuchroo VK. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol. 2009 Feb; 10(2):167-75.
    View in: PubMed
  61. Brooks DG, Ha SJ, Elsaesser H, Sharpe AH, Freeman GJ, Oldstone MB. IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20428-33.
    View in: PubMed
  62. Gotsman I, Sharpe AH, Lichtman AH. T-cell costimulation and coinhibition in atherosclerosis. Circ Res. 2008 Nov 21; 103(11):1220-31.
    View in: PubMed
  63. Lucas JA, Menke J, Rabacal WA, Schoen FJ, Sharpe AH, Kelley VR. Programmed death ligand 1 regulates a critical checkpoint for autoimmune myocarditis and pneumonitis in MRL mice. J Immunol. 2008 Aug 15; 181(4):2513-21.
    View in: PubMed
  64. Taylor PA, Ehrhardt MJ, Lees CJ, Panoskaltsis-Mortari A, Krieg AM, Sharpe AH, Murphy WJ, Serody JS, Hemmi H, Akira S, Levy RB, Blazar BR. TLR agonists regulate alloresponses and uncover a critical role for donor APCs in allogeneic bone marrow rejection. Blood. 2008 Oct 15; 112(8):3508-16.
    View in: PubMed
  65. Duan B, Niu H, Xu Z, Sharpe AH, Croker BP, Sobel ES, Morel L. Intrafollicular location of marginal zone/CD1d(hi) B cells is associated with autoimmune pathology in a mouse model of lupus. Lab Invest. 2008 Sep; 88(9):1008-20.
    View in: PubMed
  66. Butte MJ, Peña-Cruz V, Kim MJ, Freeman GJ, Sharpe AH. Interaction of human PD-L1 and B7-1. Mol Immunol. 2008 Aug; 45(13):3567-72.
    View in: PubMed
  67. Akbari O, Stock P, Meyer EH, Freeman GJ, Sharpe AH, Umetsu DT, DeKruyff RH. ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival. J Immunol. 2008 Apr 15; 180(8):5448-56.
    View in: PubMed
  68. Ha SJ, Mueller SN, Wherry EJ, Barber DL, Aubert RD, Sharpe AH, Freeman GJ, Ahmed R. Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J Exp Med. 2008 Mar 17; 205(3):543-55.
    View in: PubMed
  69. Cunninghame Graham DS, Vyse TJ, Fortin PR, Montpetit A, Cai YC, Lim S, McKenzie T, Farwell L, Rhodes B, Chad L, Hudson TJ, Sharpe A, Terhorst C, Greenwood CM, Wither J, Rioux JD. Association of LY9 in UK and Canadian SLE families. Genes Immun. 2008 Mar; 9(2):93-102.
    View in: PubMed
  70. Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol. 2008; 26:677-704.
    View in: PubMed
  71. Kobayashi N, Karisola P, Peña-Cruz V, Dorfman DM, Jinushi M, Umetsu SE, Butte MJ, Nagumo H, Chernova I, Zhu B, Sharpe AH, Ito S, Dranoff G, Kaplan GG, Casasnovas JM, Umetsu DT, Dekruyff RH, Freeman GJ. TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells. Immunity. 2007 Dec; 27(6):927-40.
    View in: PubMed
  72. Menke J, Lucas JA, Zeller GC, Keir ME, Huang XR, Tsuboi N, Mayadas TN, Lan HY, Sharpe AH, Kelley VR. Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles. J Immunol. 2007 Dec 1; 179(11):7466-77.
    View in: PubMed
  73. Grabie N, Gotsman I, DaCosta R, Pang H, Stavrakis G, Butte MJ, Keir ME, Freeman GJ, Sharpe AH, Lichtman AH. Endothelial programmed death-1 ligand 1 (PD-L1) regulates CD8+ T-cell mediated injury in the heart. Circulation. 2007 Oct 30; 116(18):2062-71.
    View in: PubMed
  74. Keir ME, Freeman GJ, Sharpe AH. PD-1 regulates self-reactive CD8+ T cell responses to antigen in lymph nodes and tissues. J Immunol. 2007 Oct 15; 179(8):5064-70.
    View in: PubMed
  75. Gotsman I, Grabie N, Dacosta R, Sukhova G, Sharpe A, Lichtman AH. Proatherogenic immune responses are regulated by the PD-1/PD-L pathway in mice. J Clin Invest. 2007 Oct; 117(10):2974-82.
    View in: PubMed
  76. Mueller SN, Matloubian M, Clemens DM, Sharpe AH, Freeman GJ, Gangappa S, Larsen CP, Ahmed R. Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15430-5.
    View in: PubMed
  77. Shen L, Jin Y, Freeman GJ, Sharpe AH, Dana MR. The function of donor versus recipient programmed death-ligand 1 in corneal allograft survival. J Immunol. 2007 Sep 15; 179(6):3672-9.
    View in: PubMed
  78. Tai X, Van Laethem F, Sharpe AH, Singer A. Induction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation. Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13756-61.
    View in: PubMed
  79. Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity. 2007 Jul; 27(1):111-22.
    View in: PubMed
  80. Love VA, Grabie N, Duramad P, Stavrakis G, Sharpe A, Lichtman A. CTLA-4 ablation and interleukin-12 driven differentiation synergistically augment cardiac pathogenicity of cytotoxic T lymphocytes. Circ Res. 2007 Aug 3; 101(3):248-57.
    View in: PubMed
  81. Kwan KY, Greenwald RJ, Mohanty S, Sharpe AH, Shaw AC, Wang JC. Development of autoimmunity in mice lacking DNA topoisomerase 3beta. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9242-7.
    View in: PubMed
  82. Kim G, Levin M, Schoenberger SP, Sharpe A, Kronenberg M. Paradoxical effect of reduced costimulation in T cell-mediated colitis. J Immunol. 2007 May 1; 178(9):5563-70.
    View in: PubMed
  83. Keir ME, Francisco LM, Sharpe AH. PD-1 and its ligands in T-cell immunity. Curr Opin Immunol. 2007 Jun; 19(3):309-14.
    View in: PubMed
  84. Sharpe AH, Wherry EJ, Ahmed R, Freeman GJ. The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection. Nat Immunol. 2007 Mar; 8(3):239-45.
    View in: PubMed
  85. Gotsman I, Grabie N, Gupta R, Dacosta R, MacConmara M, Lederer J, Sukhova G, Witztum JL, Sharpe AH, Lichtman AH. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation. 2006 Nov 7; 114(19):2047-55.
    View in: PubMed
  86. Read S, Greenwald R, Izcue A, Robinson N, Mandelbrot D, Francisco L, Sharpe AH, Powrie F. Blockade of CTLA-4 on CD4+CD25+ regulatory T cells abrogates their function in vivo. J Immunol. 2006 Oct 1; 177(7):4376-83.
    View in: PubMed
  87. Freeman GJ, Wherry EJ, Ahmed R, Sharpe AH. Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J Exp Med. 2006 Oct 2; 203(10):2223-7.
    View in: PubMed
  88. Sharpe AH, Abbas AK. T-cell costimulation--biology, therapeutic potential, and challenges. N Engl J Med. 2006 Sep 7; 355(10):973-5.
    View in: PubMed
  89. Kim G, Schoenberger SP, Sharpe A, Kronenberg M. Synergistic costimulation by both B7 molecules regulates colitis pathogenesis. Ann N Y Acad Sci. 2006 Aug; 1072:233-41.
    View in: PubMed
  90. Keir ME, Liang SC, Guleria I, Latchman YE, Qipo A, Albacker LA, Koulmanda M, Freeman GJ, Sayegh MH, Sharpe AH. Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med. 2006 Apr 17; 203(4):883-95.
    View in: PubMed
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  121. Ariyan C, Salvalaggio P, Fecteau S, Deng S, Rogozinski L, Mandelbrot D, Sharpe A, Sayegh MH, Basadonna GP, Rothstein DM. Cutting edge: transplantation tolerance through enhanced CTLA-4 expression. J Immunol. 2003 Dec 1; 171(11):5673-7.
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  124. Ryeom S, Greenwald RJ, Sharpe AH, McKeon F. The threshold pattern of calcineurin-dependent gene expression is altered by loss of the endogenous inhibitor calcipressin. Nat Immunol. 2003 Sep; 4(9):874-81.
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  132. Green KA, Cook WJ, Sharpe AH, Green WR. The CD154/CD40 interaction required for retrovirus-induced murine immunodeficiency syndrome is not mediated by upregulation of the CD80/CD86 costimulatory molecules. J Virol. 2002 Dec; 76(24):13106-10.
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  136. Schneider H, Mandelbrot DA, Greenwald RJ, Ng F, Lechler R, Sharpe AH, Rudd CE. Cutting edge: CTLA-4 (CD152) differentially regulates mitogen-activated protein kinases (extracellular signal-regulated kinase and c-Jun N-terminal kinase) in CD4+ T cells from receptor/ligand-deficient mice. J Immunol. 2002 Oct 1; 169(7):3475-9.
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  137. Mencacci A, Montagnoli C, Bacci A, Cenci E, Pitzurra L, Spreca A, Kopf M, Sharpe AH, Romani L. CD80+Gr-1+ myeloid cells inhibit development of antifungal Th1 immunity in mice with candidiasis. J Immunol. 2002 Sep 15; 169(6):3180-90.
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  155. Witke W, Sutherland JD, Sharpe A, Arai M, Kwiatkowski DJ. Profilin I is essential for cell survival and cell division in early mouse development. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3832-6.
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  156. Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol. 2001 Mar; 2(3):261-8.
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  169. Lombard DB, Beard C, Johnson B, Marciniak RA, Dausman J, Bronson R, Buhlmann JE, Lipman R, Curry R, Sharpe A, Jaenisch R, Guarente L. Mutations in the WRN gene in mice accelerate mortality in a p53-null background. Mol Cell Biol. 2000 May; 20(9):3286-91.
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  173. Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, Vagner C, Bonnet H, Dikkes P, Sharpe A, McKeon F, Caput D. p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours. Nature. 2000 Mar 2; 404(6773):99-103.
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  174. Mark DA, Donovan CE, De Sanctis GT, He HZ, Cernadas M, Kobzik L, Perkins DL, Sharpe A, Finn PW. B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness. Am J Respir Cell Mol Biol. 2000 Mar; 22(3):265-71.
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  176. Lynch WP, Sharpe AH. Differential glycosylation of the Cas-Br-E env protein is associated with retrovirus-induced spongiform neurodegeneration. J Virol. 2000 Feb; 74(3):1558-65.
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  187. Oosterwegel MA, Mandelbrot DA, Boyd SD, Lorsbach RB, Jarrett DY, Abbas AK, Sharpe AH. The role of CTLA-4 in regulating Th2 differentiation. J Immunol. 1999 Sep 1; 163(5):2634-9.
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  188. Humphries DE, Wong GW, Friend DS, Gurish MF, Qiu WT, Huang C, Sharpe AH, Stevens RL. Heparin is essential for the storage of specific granule proteases in mast cells. Nature. 1999 Aug 19; 400(6746):769-72.
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  189. Liang B, Gee RJ, Kashgarian MJ, Sharpe AH, Mamula MJ. B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies. J Immunol. 1999 Aug 15; 163(4):2322-9.
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  190. Lynch WP, Sharpe AH, Snyder EY. Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration. J Virol. 1999 Aug; 73(8):6841-51.
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  191. Blazar BR, Taylor PA, Panoskaltsis-Mortari A, Sharpe AH, Vallera DA. Opposing roles of CD28:B7 and CTLA-4:B7 pathways in regulating in vivo alloresponses in murine recipients of MHC disparate T cells. J Immunol. 1999 Jun 1; 162(11):6368-77.
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  192. Oosterwegel MA, Greenwald RJ, Mandelbrot DA, Lorsbach RB, Sharpe AH. CTLA-4 and T cell activation. Curr Opin Immunol. 1999 Jun; 11(3):294-300.
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  193. Khattri R, Auger JA, Griffin MD, Sharpe AH, Bluestone JA. Lymphoproliferative disorder in CTLA-4 knockout mice is characterized by CD28-regulated activation of Th2 responses. J Immunol. 1999 May 15; 162(10):5784-91.
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  194. Yang A, Schweitzer R, Sun D, Kaghad M, Walker N, Bronson RT, Tabin C, Sharpe A, Caput D, Crum C, McKeon F. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature. 1999 Apr 22; 398(6729):714-8.
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  195. La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB. Host B7-1 and B7-2 costimulatory molecules contribute to the eradication of B7-1-transfected P815 tumor cells via a CD8+ T cell-dependent mechanism. J Immunol. 1999 Apr 15; 162(8):4817-23.
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  196. Greenwald RJ, Urban JF, Ekkens MJ, Chen S, Nguyen D, Fang H, Finkelman FD, Sharpe AH, Gause WC. B7-2 is required for the progression but not the initiation of the type 2 immune response to a gastrointestinal nematode parasite. J Immunol. 1999 Apr 1; 162(7):4133-9.
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  197. Hernandez HJ, Sharpe AH, Stadecker MJ. Experimental murine schistosomiasis in the absence of B7 costimulatory molecules: reversal of elicited T cell cytokine profile and partial inhibition of egg granuloma formation. J Immunol. 1999 Mar 1; 162(5):2884-9.
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  198. Judge TA, Wu Z, Zheng XG, Sharpe AH, Sayegh MH, Turka LA. The role of CD80, CD86, and CTLA4 in alloimmune responses and the induction of long-term allograft survival. J Immunol. 1999 Feb 15; 162(4):1947-51.
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  199. González-Cabrero J, Wise CJ, Latchman Y, Freeman GJ, Sharpe AH, Reiser H. CD48-deficient mice have a pronounced defect in CD4(+) T cell activation. Proc Natl Acad Sci U S A. 1999 Feb 2; 96(3):1019-23.
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  200. Mandelbrot DA, McAdam AJ, Sharpe AH. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). J Exp Med. 1999 Jan 18; 189(2):435-40.
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  201. La Motte RN, Sharpe AH, Bluestone JA, Mokyr MB. Importance of B7-1-expressing host antigen-presenting cells for the eradication of B7-2 transfected P815 tumor cells. J Immunol. 1998 Dec 15; 161(12):6552-8.
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  202. Rauschmayr-Kopp T, Williams IR, Borriello F, Sharpe AH, Kupper TS. Distinct roles for B7 costimulation in contact hypersensitivity and humoral immune responses to epicutaneous antigen. Eur J Immunol. 1998 Dec; 28(12):4221-7.
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  203. Wang B, Wang N, Salio M, Sharpe A, Allen D, She J, Terhorst C. Essential and partially overlapping role of CD3gamma and CD3delta for development of alphabeta and gammadelta T lymphocytes. J Exp Med. 1998 Oct 5; 188(7):1375-80.
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  204. McAdam AJ, Schweitzer AN, Sharpe AH. The role of B7 co-stimulation in activation and differentiation of CD4+ and CD8+ T cells. Immunol Rev. 1998 Oct; 165:231-47.
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  205. Schweitzer AN, Sharpe AH. Studies using antigen-presenting cells lacking expression of both B7-1 (CD80) and B7-2 (CD86) show distinct requirements for B7 molecules during priming versus restimulation of Th2 but not Th1 cytokine production. J Immunol. 1998 Sep 15; 161(6):2762-71.
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  206. Robert LS, Robson F, Sharpe A, Lydiate D, Coupland G. Conserved structure and function of the Arabidopsis flowering time gene CONSTANS in Brassica napus. Plant Mol Biol. 1998 Jul; 37(5):763-72.
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  207. Schweitzer AN, Sharpe AH. The complexity of the B7-CD28/CTLA-4 costimulatory pathway. Agents Actions Suppl. 1998; 49:33-43.
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  208. Avramis VI, Wiersma S, Krailo MD, Ramilo-Torno LV, Sharpe A, Liu-Mares W, Kowck R, Reaman GH, Sato JK. Pharmacokinetic and pharmacodynamic studies of fludarabine and cytosine arabinoside administered as loading boluses followed by continuous infusions after a phase I/II study in pediatric patients with relapsed leukemias. The Children's Cancer Group. Clin Cancer Res. 1998 Jan; 4(1):45-52.
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  209. Van Parijs L, Sethna MP, Schweitzer AN, Borriello F, Sharpe AH, Abbas AK. Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice. J Immunol. 1997 Dec 1; 159(11):5336-44.
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  210. Reeves RH, Patch D, Sharpe AH, Borriello F, Freeman GJ, Edelhoff S, Disteche C. The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3. Mamm Genome. 1997 Aug; 8(8):581-2.
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  211. Zheng XX, Sayegh MH, Zheng XG, Li Y, Linsley PS, Peach R, Borriello F, Strom TB, Sharpe AH, Turka LA. The role of donor and recipient B7-1 (CD80) in allograft rejection. J Immunol. 1997 Aug 1; 159(3):1169-73.
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  212. Tivol EA, Boyd SD, McKeon S, Borriello F, Nickerson P, Strom TB, Sharpe AH. CTLA4Ig prevents lymphoproliferation and fatal multiorgan tissue destruction in CTLA-4-deficient mice. J Immunol. 1997 Jun 1; 158(11):5091-4.
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  213. Borriello F, Lederer J, Scott S, Sharpe AH. MRC OX-2 defines a novel T cell costimulatory pathway. J Immunol. 1997 May 15; 158(10):4548-54.
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  214. Schweitzer AN, Borriello F, Wong RC, Abbas AK, Sharpe AH. Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86. J Immunol. 1997 Mar 15; 158(6):2713-22.
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  215. Yergeau DA, Hetherington CJ, Wang Q, Zhang P, Sharpe AH, Binder M, Marín-Padilla M, Tenen DG, Speck NA, Zhang DE. Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet. 1997 Mar; 15(3):303-6.
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  216. Borriello F, Sethna MP, Boyd SD, Schweitzer AN, Tivol EA, Jacoby D, Strom TB, Simpson EM, Freeman GJ, Sharpe AH. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity. 1997 Mar; 6(3):303-13.
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  217. Greenfield EA, Howard E, Paradis T, Nguyen K, Benazzo F, McLean P, Höllsberg P, Davis G, Hafler DA, Sharpe AH, Freeman GJ, Kuchroo VK. B7.2 expressed by T cells does not induce CD28-mediated costimulatory activity but retains CTLA4 binding: implications for induction of antitumor immunity to T cell tumors. J Immunol. 1997 Mar 1; 158(5):2025-34.
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  218. Coxon A, Rieu P, Barkalow FJ, Askari S, Sharpe AH, von Andrian UH, Arnaout MA, Mayadas TN. A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996 Dec; 5(6):653-66.
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  219. Lynch WP, Snyder EY, Qualtiere L, Portis JL, Sharpe AH. Late virus replication events in microglia are required for neurovirulent retrovirus-induced spongiform neurodegeneration: evidence from neural progenitor-derived chimeric mouse brains. J Virol. 1996 Dec; 70(12):8896-907.
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  220. Tivol EA, Schweitzer AN, Sharpe AH. Costimulation and autoimmunity. Curr Opin Immunol. 1996 Dec; 8(6):822-30.
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  221. Wang JH, Nichogiannopoulou A, Wu L, Sun L, Sharpe AH, Bigby M, Georgopoulos K. Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity. 1996 Dec; 5(6):537-49.
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  222. Wang Q, Stacy T, Miller JD, Lewis AF, Gu TL, Huang X, Bushweller JH, Bories JC, Alt FW, Ryan G, Liu PP, Wynshaw-Boris A, Binder M, Marín-Padilla M, Sharpe AH, Speck NA. The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell. 1996 Nov 15; 87(4):697-708.
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  223. Blazar BR, Sharpe AH, Taylor PA, Panoskaltsis-Mortari A, Gray GS, Korngold R, Vallera DA. Infusion of anti-B7.1 (CD80) and anti-B7.2 (CD86) monoclonal antibodies inhibits murine graft-versus-host disease lethality in part via direct effects on CD4+ and CD8+ T cells. J Immunol. 1996 Oct 15; 157(8):3250-9.
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  224. Sadanandom A, Piffanelli P, Knott T, Robinson C, Sharpe A, Lydiate D, Murphy D, Fairbairn DJ. Identification of a peptide methionine sulphoxide reductase gene in an oleosin promoter from Brassica napus. Plant J. 1996 Aug; 10(2):235-42.
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  225. Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3444-9.
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  226. Borriello F, Oliveros J, Freeman GJ, Nadler LM, Sharpe AH. Differential expression of alternate mB7-2 transcripts. J Immunol. 1995 Dec 15; 155(12):5490-7.
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  227. Thomis DC, Gurniak CB, Tivol E, Sharpe AH, Berg LJ. Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science. 1995 Nov 3; 270(5237):794-7.
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  228. Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995 Nov; 3(5):541-7.
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  229. Sharpe AH. Analysis of lymphocyte costimulation in vivo using transgenic and 'knockout' mice. Curr Opin Immunol. 1995 Jun; 7(3):389-95.
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  230. Perkins AC, Sharpe AH, Orkin SH. Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature. 1995 May 25; 375(6529):318-22.
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  231. Johnson KA, Lerner CP, Di Lacio LC, Laird PW, Sharpe AH, Simpson EM. Transgenic mice for the preparation of hygromycin-resistant primary embryonic fibroblast feeder layers for embryonic stem cell selections. Nucleic Acids Res. 1995 Apr 11; 23(7):1273-5.
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  232. Witke W, Sharpe AH, Hartwig JH, Azuma T, Stossel TP, Kwiatkowski DJ. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell. 1995 Apr 7; 81(1):41-51.
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  233. Gurtner GC, Davis V, Li H, McCoy MJ, Sharpe A, Cybulsky MI. Targeted disruption of the murine VCAM1 gene: essential role of VCAM-1 in chorioallantoic fusion and placentation. Genes Dev. 1995 Jan 1; 9(1):1-14.
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  234. Jellis CL, Wang SS, Rennert P, Borriello F, Sharpe AH, Green NR, Gray GS. Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86). Immunogenetics. 1995; 42(2):85-9.
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  235. Prabhu Das MR, Zamvil SS, Borriello F, Weiner HL, Sharpe AH, Kuchroo VK. Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation. Eur J Immunol. 1995 Jan; 25(1):207-11.
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  236. Borriello F, Freeman GJ, Edelhoff S, Disteche CM, Nadler LM, Sharpe AH. Characterization of the murine B7-1 genomic locus reveals an additional exon encoding an alternative cytoplasmic domain and a chromosomal location of chromosome 16, band B5. J Immunol. 1994 Dec 1; 153(11):5038-48.
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  237. Georgopoulos K, Bigby M, Wang JH, Molnar A, Wu P, Winandy S, Sharpe A. The Ikaros gene is required for the development of all lymphoid lineages. Cell. 1994 Oct 7; 79(1):143-56.
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  238. Hills MJ, Dann R, Lydiate D, Sharpe A. Molecular cloning of a cDNA from Brassica napus L. for a homologue of acyl-CoA-binding protein. Plant Mol Biol. 1994 Aug; 25(5):917-20.
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  239. Sethna MP, van Parijs L, Sharpe AH, Abbas AK, Freeman GJ. A negative regulatory function of B7 revealed in B7-1 transgenic mice. Immunity. 1994 Aug; 1(5):415-21.
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  240. Sharpe AH, Jaenisch R. Retroviral spongiform degenerative disease produced by the murine neurotropic retrovirus Cas-Br-E. Dev Biol Stand. 1993; 80:45-52.
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  241. Lee KF, Li E, Huber LJ, Landis SC, Sharpe AH, Chao MV, Jaenisch R. Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell. 1992 May 29; 69(5):737-49.
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  242. Huszar D, Sharpe A, Hashmi S, Bouchard B, Houghton A, Jaenisch R. Generation of pigmented stripes in albino mice by retroviral marking of neural crest melanoblasts. Development. 1991 Oct; 113(2):653-60.
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  243. Huszar D, Sharpe A, Jaenisch R. Migration and proliferation of cultured neural crest cells in W mutant neural crest chimeras. Development. 1991 May; 112(1):131-41.
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  244. Lee JS, Mullaney S, Bronson R, Sharpe AH, Jaenisch R, Balzarini J, De Clercq E, Ruprecht RM. Transplacental antiretroviral therapy with 9-(2-phosphonylmethoxyethyl)adenine is embryotoxic in transgenic mice. J Acquir Immune Defic Syndr. 1991; 4(9):833-8.
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  245. Weiher H, Noda T, Gray DA, Sharpe AH, Jaenisch R. Transgenic mouse model of kidney disease: insertional inactivation of ubiquitously expressed gene leads to nephrotic syndrome. Cell. 1990 Aug 10; 62(3):425-34.
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  246. Sharpe AH, Hunter JJ, Chassler P, Jaenisch R. Role of abortive retroviral infection of neurons in spongiform CNS degeneration. Nature. 1990 Jul 12; 346(6280):181-3.
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  247. Ruprecht RM, Sharpe AH, Jaenisch R, Trites D. Analysis of 3'-azido-3'-deoxythymidine levels in tissues and milk by isocratic high-performance liquid chromatography. J Chromatogr. 1990 Jun 29; 528(2):371-83.
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  248. Wu H, Bateman JF, Schnieke A, Sharpe A, Barker D, Mascara T, Eyre D, Bruns R, Krimpenfort P, Berns A, et al. Human-mouse interspecies collagen I heterotrimer is functional during embryonic development of Mov13 mutant mouse embryos. Mol Cell Biol. 1990 Apr; 10(4):1452-60.
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  249. Sugimoto M, Sharpe AH, Sato Y, Greene MI, Fields BN. Reovirus transport--studies using lymphocytosis promoting factor. Pathobiology. 1990; 58(4):185-92.
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  250. Compere SJ, Baldacci P, Sharpe AH, Thompson T, Land H, Jaenisch R. The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors. Proc Natl Acad Sci U S A. 1989 Apr; 86(7):2224-8.
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  251. Sharpe AH, Hunter JJ, Ruprecht RM, Jaenisch R. Maternal transmission of retroviral disease and strategies for preventing infection of the neonate. J Virol. 1989 Mar; 63(3):1049-53.
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  252. Compere SJ, Baldacci PA, Sharpe AH, Jaenisch R. Retroviral transduction of the human c-Ha-ras-1 oncogene into midgestation mouse embryos promotes rapid epithelial hyperplasia. Mol Cell Biol. 1989 Jan; 9(1):6-14.
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  253. Sharpe AH, Hunter JJ, Ruprecht RM, Jaenisch R. Maternal transmission of retroviral disease: transgenic mice as a rapid test system for evaluating perinatal and transplacental antiretroviral therapy. Proc Natl Acad Sci U S A. 1988 Dec; 85(24):9792-6.
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  254. Sharpe AH, Jaenisch R, Ruprecht RM. Retroviruses and mouse embryos: a rapid model for neurovirulence and transplacental antiviral therapy. Science. 1987 Jun 26; 236(4809):1671-4.
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  255. Wolf JL, Dambrauskas R, Sharpe AH, Trier JS. Adherence to and penetration of the intestinal epithelium by reovirus type 1 in neonatal mice. Gastroenterology. 1987 Jan; 92(1):82-91.
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  256. Gaulton GN, Sharpe AH, Chang DW, Fields BN, Greene MI. Syngeneic monoclonal internal image anti-idiotopes as prophylactic vaccines. J Immunol. 1986 Nov 1; 137(9):2930-6.
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  257. Sharpe AH, Gaulton GN, Ertl HC, Finberg RW, McDade KK, Fields BN, Greene MI. Cell receptors for the mammalian reovirus. IV. Reovirus-specific cytolytic T cell lines that have idiotypic receptors recognize anti-idiotypic B cell hybridomas. J Immunol. 1985 Apr; 134(4):2702-6.
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  258. Sharpe AH, Fields BN. Pathogenesis of viral infections. Basic concepts derived from the reovirus model. N Engl J Med. 1985 Feb 21; 312(8):486-97.
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  259. Sharpe AH, Gaulton GN, McDade KK, Fields BN, Greene MI. Syngeneic monoclonal antiidiotype can induce cellular immunity to reovirus. J Exp Med. 1984 Oct 1; 160(4):1195-205.
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  260. Sharpe AH, Fields BN. Reovirus inhibition of cellular RNA and protein synthesis: role of the S4 gene. Virology. 1982 Oct 30; 122(2):381-91.
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  261. Sharpe AH, Chen LB, Fields BN. The interaction of mammalian reoviruses with the cytoskeleton of monkey kidney CV-1 cells. Virology. 1982 Jul 30; 120(2):399-411.
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  262. Ahmed R, Canning WM, Kauffman RS, Sharpe AH, Hallum JV, Fields BN. Role of the host cell in persistent viral infection: coevolution of L cells and reovoirus during persistent infection. Cell. 1981 Aug; 25(2):325-32.
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  263. Wolf JL, Rubin DH, Finberg R, Kauffman RS, Sharpe AH, Trier JS, Fields BN. Intestinal M cells: a pathway for entry of reovirus into the host. Science. 1981 Apr 24; 212(4493):471-2.
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  264. Sharpe AH, Fields BN. Reovirus inhibition of cellular DNA synthesis: role of the S1 gene. J Virol. 1981 Apr; 38(1):389-92.
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  265. Sharpe AH, Chen LB, Murphy JR, Fields BN. Specific disruption of vimentin filament organization in monkey kidney CV-1 cells by diphtheria toxin, exotoxin A, and cycloheximide. Proc Natl Acad Sci U S A. 1980 Dec; 77(12):7267-71.
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  266. Fields BN, Weiner HL, Drayna DT, Sharpe AH. The role of the reovirus hemagglutinin in viral virulence. Ann N Y Acad Sci. 1980; 354:125-34.
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  267. Mustoe TA, Ramig RF, Sharpe AH, Fields BN. Genetics of reovirus: identification of the ds RNA segments encoding the polypeptides of the mu and sigma size classes. Virology. 1978 Sep; 89(2):594-604.
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  268. Mustoe TA, Ramig RF, Sharpe AH, Fields BN. A genetic map of reovirus. III. Assignment of the double-stranded RNA-positive mutant groups A, B, and G to genome segments. Virology. 1978 Apr; 85(2):545-56.
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  269. Ramig RF, Mustoe TA, Sharpe AH, Fields BN. A genetic map of reovirus. II. Assignment of the double-stranded RNA-negative mutant groups C, D, and E to genome segments. Virology. 1978 Apr; 85(2):531-4.
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  270. Sharpe AH, Ramig RF, Mustoe TA, Fields BN. A genetic map of reovirus. 1. Correlation of genome RNAs between serotypes 1, 2, and 3. Virology. 1978 Jan; 84(1):63-74.
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